H1FNT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. The related mouse gene encodes a testis specific protein that is required for spermatogenesis and male fertility. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.89803131
2axonemal dynein complex assembly (GO:0070286)9.79163040
3epithelial cilium movement (GO:0003351)9.76542221
4motile cilium assembly (GO:0044458)9.39577414
5reproduction (GO:0000003)9.34259013
6cilium or flagellum-dependent cell motility (GO:0001539)8.93938789
7regulation of cilium movement (GO:0003352)8.82844924
8response to pheromone (GO:0019236)8.61503286
9cilium movement (GO:0003341)7.89370817
10single fertilization (GO:0007338)7.47790102
11rRNA methylation (GO:0031167)7.29761663
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.24438572
13sperm capacitation (GO:0048240)7.13423306
14negative regulation of inclusion body assembly (GO:0090084)7.13236061
15piRNA metabolic process (GO:0034587)7.01588019
16synaptonemal complex organization (GO:0070193)7.01420837
17spermatogenesis (GO:0007283)6.89072584
18organic cation transport (GO:0015695)6.88115014
19male gamete generation (GO:0048232)6.86693343
20negative regulation of retinoic acid receptor signaling pathway (GO:0048387)6.86059488
21male meiosis (GO:0007140)6.82281401
22synaptonemal complex assembly (GO:0007130)6.81307306
23phosphatidylethanolamine biosynthetic process (GO:0006646)6.69622075
24microtubule depolymerization (GO:0007019)6.57364975
25fertilization (GO:0009566)6.37845721
26gamete generation (GO:0007276)6.31301649
27rRNA modification (GO:0000154)6.23299929
28protein targeting to Golgi (GO:0000042)6.22131157
29phosphatidylethanolamine metabolic process (GO:0046337)6.18040901
30regulation of inclusion body assembly (GO:0090083)5.96968325
31establishment of protein localization to Golgi (GO:0072600)5.96433047
32retrograde transport, vesicle recycling within Golgi (GO:0000301)5.77966341
33calcium ion-dependent exocytosis (GO:0017156)5.71015720
34regulation of retinoic acid receptor signaling pathway (GO:0048385)5.60789702
35cellular ketone body metabolic process (GO:0046950)5.58107975
36germ cell development (GO:0007281)5.52309174
37* cellular process involved in reproduction in multicellular organism (GO:0022412)5.34895298
38ventricular system development (GO:0021591)5.21871854
39regulation of microtubule-based movement (GO:0060632)5.20777848
40cell recognition (GO:0008037)5.07371558
41centriole replication (GO:0007099)5.05332324
42regulation of Rab GTPase activity (GO:0032313)5.00015344
43positive regulation of Rab GTPase activity (GO:0032851)5.00015344
44multicellular organismal reproductive process (GO:0048609)4.97204533
45male meiosis I (GO:0007141)4.93727351
46ketone body metabolic process (GO:1902224)4.91789679
47glycerol ether metabolic process (GO:0006662)4.88014254
48seminiferous tubule development (GO:0072520)4.84418266
49microtubule severing (GO:0051013)4.81422381
50spermatid nucleus differentiation (GO:0007289)4.78701965
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.77447154
52chromosome organization involved in meiosis (GO:0070192)4.63505397
53DNA methylation involved in gamete generation (GO:0043046)4.60796168
54ether metabolic process (GO:0018904)4.50796272
55left/right pattern formation (GO:0060972)4.50626975
56regulation of transcription involved in cell fate commitment (GO:0060850)4.49769635
57protein localization to Golgi apparatus (GO:0034067)4.40602113
58* DNA packaging (GO:0006323)4.30749289
59* chromosome condensation (GO:0030261)4.30220292
60meiotic nuclear division (GO:0007126)4.14961960
61sexual reproduction (GO:0019953)4.11777082
62response to acidic pH (GO:0010447)4.06146991
63sequestering of actin monomers (GO:0042989)4.03506873
64single strand break repair (GO:0000012)3.97694077
65regulation of centriole replication (GO:0046599)3.97340822
66chaperone-mediated protein complex assembly (GO:0051131)3.95256079
67meiosis I (GO:0007127)3.94631790
68* multicellular organismal development (GO:0007275)3.90515261
69histone H3-K9 demethylation (GO:0033169)3.83124481
70cellular response to pH (GO:0071467)3.74848913
71genitalia morphogenesis (GO:0035112)3.64826021
72coenzyme catabolic process (GO:0009109)3.63975231
73protein polyglutamylation (GO:0018095)3.61364184
74negative regulation of Rho protein signal transduction (GO:0035024)3.53438940
75peptidyl-threonine dephosphorylation (GO:0035970)3.50187636
76regulation of spindle checkpoint (GO:0090231)3.46680443
77musculoskeletal movement (GO:0050881)3.42224213
78multicellular organismal movement (GO:0050879)3.42224213
79meiotic cell cycle (GO:0051321)3.41282347
80cerebral cortex neuron differentiation (GO:0021895)3.38729138
81RNA localization (GO:0006403)3.36420910
82microtubule polymerization or depolymerization (GO:0031109)3.36397123
83protein refolding (GO:0042026)3.35425186
84RNA destabilization (GO:0050779)3.34571128
85negative regulation of gene expression, epigenetic (GO:0045814)3.31065878
86interferon-gamma secretion (GO:0072643)3.28683975
87protein localization to cilium (GO:0061512)3.28547398
88amino-acid betaine transport (GO:0015838)3.25959252
89carnitine transport (GO:0015879)3.25959252
90cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.25876450
91monoubiquitinated protein deubiquitination (GO:0035520)3.24446013
92protein K11-linked deubiquitination (GO:0035871)3.23089893
93regulation of interleukin-13 production (GO:0032656)3.20427389
94homeostasis of number of cells within a tissue (GO:0048873)3.16785803
95regulation of T-helper 2 cell differentiation (GO:0045628)3.16549258
96glycolytic process (GO:0006096)3.10399408
97carnitine transmembrane transport (GO:1902603)3.08377943
98mitotic sister chromatid cohesion (GO:0007064)3.02735250
99protein depolymerization (GO:0051261)3.01439149
100membrane protein intracellular domain proteolysis (GO:0031293)3.01027720
101* nucleus organization (GO:0006997)3.00397483
102positive regulation of macrophage activation (GO:0043032)2.99606265
103regulation of phosphoprotein phosphatase activity (GO:0043666)2.98044889
104negative regulation of histone methylation (GO:0031061)2.96826218
105cranial nerve morphogenesis (GO:0021602)2.95905832
106polyol catabolic process (GO:0046174)2.94555409
107nucleoside diphosphate phosphorylation (GO:0006165)2.93846717
108polyamine biosynthetic process (GO:0006596)2.90550554
109mesenchymal cell differentiation involved in kidney development (GO:0072161)2.89813688
110mesenchymal cell differentiation involved in renal system development (GO:2001012)2.89813688
111regulation of somitogenesis (GO:0014807)2.85385901
112regulation of female gonad development (GO:2000194)2.84618096
113histone exchange (GO:0043486)2.84533418
114alditol metabolic process (GO:0019400)2.83164648
115cilium organization (GO:0044782)2.80849274
116meiotic cell cycle process (GO:1903046)2.77880880
117microtubule nucleation (GO:0007020)2.75825108
118mitochondrial fission (GO:0000266)2.75795153
119lactate metabolic process (GO:0006089)2.74814697
120synapsis (GO:0007129)2.72470073
121microtubule-based movement (GO:0007018)2.71275980
122axoneme assembly (GO:0035082)2.69959394
123regulation of cilium assembly (GO:1902017)2.69950296
124cilium assembly (GO:0042384)2.68848704
125cilium morphogenesis (GO:0060271)2.64991851
126cellular component assembly involved in morphogenesis (GO:0010927)2.64291035
127chromatin silencing (GO:0006342)2.63405721
128negative regulation of organelle assembly (GO:1902116)2.63062542
129centriole assembly (GO:0098534)2.59324618
130GTP biosynthetic process (GO:0006183)2.59074275
131peptidyl-glutamic acid modification (GO:0018200)2.58689447
132intraciliary transport (GO:0042073)2.57567429
133protein-DNA complex disassembly (GO:0032986)2.52803522
134nucleosome disassembly (GO:0006337)2.52803522
135mitochondrion degradation (GO:0000422)2.47776942
136sperm motility (GO:0030317)14.1504594
137fusion of sperm to egg plasma membrane (GO:0007342)13.2846582
138acrosome reaction (GO:0007340)12.6702086
139cell wall macromolecule catabolic process (GO:0016998)12.6256159
140cell wall macromolecule metabolic process (GO:0044036)12.6256159
141sperm-egg recognition (GO:0035036)11.7223758
142acrosome assembly (GO:0001675)11.1810631
143multicellular organism reproduction (GO:0032504)10.8353956
144binding of sperm to zona pellucida (GO:0007339)10.6617362
145cell-cell recognition (GO:0009988)10.4933854
146plasma membrane fusion (GO:0045026)10.1163632

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.35324706
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.05862475
3EZH2_22144423_ChIP-Seq_EOC_Human4.21726573
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.76712124
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.68662752
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.61399598
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.96214730
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.95605495
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.93088919
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.82585195
11VDR_22108803_ChIP-Seq_LS180_Human2.39437294
12* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.23516382
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.22159266
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.19852718
15EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.05951962
16RAC3_21632823_ChIP-Seq_H3396_Human2.03376302
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02627840
18NANOG_20526341_ChIP-Seq_ESCs_Human2.01867095
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99892001
20* ERA_21632823_ChIP-Seq_H3396_Human1.95414763
21RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.94940547
22ZNF274_21170338_ChIP-Seq_K562_Hela1.94915980
23EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.92293327
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.91207611
25CTCF_27219007_Chip-Seq_Bcells_Human1.87667311
26ELK4_26923725_Chip-Seq_MESODERM_Mouse1.84027878
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81547463
28E2F1_20622854_ChIP-Seq_HELA_Human1.81445427
29DROSHA_22980978_ChIP-Seq_HELA_Human1.78700229
30SMC4_20622854_ChIP-Seq_HELA_Human1.75013430
31P68_20966046_ChIP-Seq_HELA_Human1.73843918
32* BCL6_27268052_Chip-Seq_Bcells_Human1.73441090
33KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.72463556
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71984010
35PHF8_20622854_ChIP-Seq_HELA_Human1.70315684
36* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69513487
37MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.68551341
38* STAT1_17558387_ChIP-Seq_HELA_Human1.66799317
39TDRD3_21172665_ChIP-Seq_MCF-7_Human1.66596028
40TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.66376541
41TAF2_19829295_ChIP-Seq_ESCs_Human1.64370177
42SOX2_22085726_ChIP-Seq_NPCs_Mouse1.63262191
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63095701
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61403196
45AUTS2_25519132_ChIP-Seq_293T-REX_Human1.59913741
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59784729
47OCT4_20526341_ChIP-Seq_ESCs_Human1.58625515
48MYC_19829295_ChIP-Seq_ESCs_Human1.58008593
49RBPJ_21746931_ChIP-Seq_IB4_Human1.55914808
50TP63_22573176_ChIP-Seq_HFKS_Human1.55303161
51WDR5_24793694_ChIP-Seq_LNCAP_Human1.53411128
52FUS_26573619_Chip-Seq_HEK293_Human1.53049856
53GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.51009247
54LXR_22292898_ChIP-Seq_THP-1_Human1.50492710
55ETV1_20927104_ChIP-Seq_GIST48_Human1.49993684
56ETV2_25802403_ChIP-Seq_MESCs_Mouse1.47568677
57HNFA_21074721_ChIP-Seq_CACO-2_Human1.47378067
58CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.47064960
59P300_27268052_Chip-Seq_Bcells_Human1.47058267
60SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.46959949
61* GATA3_21867929_ChIP-Seq_CD8_Mouse1.44775259
62FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.44716928
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44138779
64CBP_20019798_ChIP-Seq_JUKART_Human1.44138779
65KDM2B_26808549_Chip-Seq_REH_Human1.43260603
66ER_23166858_ChIP-Seq_MCF-7_Human1.42912472
67TAL1_26923725_Chip-Seq_HPCs_Mouse1.42376998
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.41003468
69SMAD4_21741376_ChIP-Seq_EPCs_Human1.40555995
70PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.38591634
71PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.37905749
72P53_21459846_ChIP-Seq_SAOS-2_Human1.37603319
73AR_25329375_ChIP-Seq_VCAP_Human1.37439269
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.36735997
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.36425217
76CBX2_22325352_ChIP-Seq_293T-Rex_Human1.36159116
77LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.33809819
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33808313
79REST_21632747_ChIP-Seq_MESCs_Mouse1.32186966
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30162531
81SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28894377
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.26891071
83SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26325597
84PHF8_20622853_ChIP-Seq_HELA_Human1.26143663
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26049717
86* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.25905296
87* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.25789832
88GATA6_21074721_ChIP-Seq_CACO-2_Human1.24144952
89CBX2_27304074_Chip-Seq_ESCs_Mouse1.23442281
90GATA3_21867929_ChIP-Seq_TH1_Mouse1.22925037
91GF1_26923725_Chip-Seq_HPCs_Mouse1.22746408
92SMAD3_21741376_ChIP-Seq_ESCs_Human1.22472907
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22295040
94RAD21_21589869_ChIP-Seq_MESCs_Mouse1.22150506
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19934088
96FLI1_21867929_ChIP-Seq_TH2_Mouse1.18374413
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18146429
98CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17665631
99SA1_27219007_Chip-Seq_Bcells_Human1.17277103
100SMRT_27268052_Chip-Seq_Bcells_Human1.16957731
101CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16341786
102CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15741827
103* GATA3_21878914_ChIP-Seq_MCF-7_Human1.15196726
104TP53_18474530_ChIP-ChIP_U2OS_Human1.15099225
105SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14729380
106GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.14158709
107SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13423964
108* CEBPB_22108803_ChIP-Seq_LS180_Human1.12243072
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11898997
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11898997
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.11001052
112SPI1_26923725_Chip-Seq_HPCs_Mouse1.10988853
113* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.10873839
114ERG_20517297_ChIP-Seq_VCAP_Human1.10757169
115PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10754500
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10642831
117EZH2_27294783_Chip-Seq_ESCs_Mouse1.10589299
118RUNX1_26923725_Chip-Seq_HPCs_Mouse1.09894508
119EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09695527
120NFYA_21822215_ChIP-Seq_K562_Human1.09143994
121MYC_27129775_Chip-Seq_CORNEA_Mouse1.08973031
122RUNX_20019798_ChIP-Seq_JUKART_Human1.08281349
123BP1_19119308_ChIP-ChIP_Hs578T_Human1.07601541
124RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07529745
125OCT4_19829295_ChIP-Seq_ESCs_Human1.07475870
126PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06887295
127CRX_20693478_ChIP-Seq_RETINA_Mouse1.06485617
128NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06485007
129TET1_21451524_ChIP-Seq_MESCs_Mouse1.05904576
130RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05833485
131NANOG_18555785_Chip-Seq_ESCs_Mouse1.04424790
132EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.04417581
133SA1_27219007_Chip-Seq_ERYTHROID_Human1.04335012
134PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.04317844
135RARA_24833708_ChIP-Seq_LIVER_Mouse1.04026650
136TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03667110
137KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03510770
138P300_19829295_ChIP-Seq_ESCs_Human1.03458401
139KLF4_19829295_ChIP-Seq_ESCs_Human1.03120186
140JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.02873368
141CTCF_20526341_ChIP-Seq_ESCs_Human1.02389910
142SMAD4_21741376_ChIP-Seq_HESCs_Human1.01721422
143CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01322722
144RUNX2_22187159_ChIP-Seq_PCA_Human1.01314114
145GATA1_19941827_ChIP-Seq_MEL86_Mouse1.00690489
146HOXB7_26014856_ChIP-Seq_BT474_Human0.99957783
147FOXH1_21741376_ChIP-Seq_ESCs_Human0.99421097
148TAF15_26573619_Chip-Seq_HEK293_Human0.99380143
149TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98879524
150PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98751627
151YY1_22570637_ChIP-Seq_MALME-3M_Human0.98087541
152* ESET_19884257_ChIP-Seq_ESCs_Mouse0.96786159
153SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95649658
154SOX11_22085726_ChIP-Seq_ESNs_Mouse0.95613040
155ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95364387
156LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94533944
157P53_22387025_ChIP-Seq_ESCs_Mouse0.94431399
158OCT4_18555785_Chip-Seq_ESCs_Mouse0.93909051
159ELF1_20517297_ChIP-Seq_JURKAT_Human0.93852452
160SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93815657
161NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93004333
162NFYB_21822215_ChIP-Seq_K562_Human0.92133685
163OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90330855
164CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89277275
165TBL1_22424771_ChIP-Seq_293T_Human0.88354247
166PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87791753
167FLI1_21867929_ChIP-Seq_CD8_Mouse0.87435751
168CMYC_18555785_Chip-Seq_ESCs_Mouse0.87047280
169STAT3_18555785_ChIP-Seq_MESCs_Mouse0.86175450
170BCOR_27268052_Chip-Seq_Bcells_Human0.85884686
171KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.85658043

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive6.07873484
2* MP0001929_abnormal_gametogenesis5.45776588
3MP0008877_abnormal_DNA_methylation3.86114277
4MP0001348_abnormal_lacrimal_gland3.52163131
5MP0002210_abnormal_sex_determination3.36693434
6* MP0002161_abnormal_fertility/fecundity3.29410488
7MP0005670_abnormal_white_adipose3.06450428
8MP0001145_abnormal_male_reproductive2.87349124
9MP0000678_abnormal_parathyroid_gland2.67365126
10MP0003718_maternal_effect2.66932903
11MP0000653_abnormal_sex_gland2.47994982
12MP0005423_abnormal_somatic_nervous2.22758789
13MP0002653_abnormal_ependyma_morphology2.12887447
14MP0002132_abnormal_respiratory_system2.07600723
15* MP0005410_abnormal_fertilization16.5946271
16MP0003646_muscle_fatigue1.89556003
17MP0002160_abnormal_reproductive_system1.80418847
18MP0005379_endocrine/exocrine_gland_phen1.69468588
19MP0002249_abnormal_larynx_morphology1.63625591
20MP0004233_abnormal_muscle_weight1.55746584
21MP0005623_abnormal_meninges_morphology1.43418245
22MP0002127_abnormal_cardiovascular_syste1.43342674
23MP0001485_abnormal_pinna_reflex1.39587013
24MP0001486_abnormal_startle_reflex1.39536978
25MP0002822_catalepsy1.37928062
26MP0009053_abnormal_anal_canal1.35208903
27MP0002138_abnormal_hepatobiliary_system1.32402385
28MP0005310_abnormal_salivary_gland1.30574185
29MP0002735_abnormal_chemical_nociception1.24944511
30MP0005395_other_phenotype1.20817367
31MP0002282_abnormal_trachea_morphology1.18479080
32MP0004859_abnormal_synaptic_plasticity1.17474228
33MP0004510_myositis1.16804504
34MP0001765_abnormal_ion_homeostasis1.15267595
35MP0005451_abnormal_body_composition1.10673177
36MP0001963_abnormal_hearing_physiology1.03758122
37MP0005248_abnormal_Harderian_gland0.98637237
38MP0005647_abnormal_sex_gland0.94721452
39MP0000026_abnormal_inner_ear0.94478689
40MP0001984_abnormal_olfaction0.92544425
41MP0005389_reproductive_system_phenotype0.91867551
42MP0006292_abnormal_olfactory_placode0.91075426
43MP0008569_lethality_at_weaning0.82411304
44MP0000049_abnormal_middle_ear0.81861137
45MP0003115_abnormal_respiratory_system0.81169756
46MP0000955_abnormal_spinal_cord0.80215042
47MP0000681_abnormal_thyroid_gland0.79780911
48MP0008995_early_reproductive_senescence0.77950476
49MP0002234_abnormal_pharynx_morphology0.77428310
50MP0002067_abnormal_sensory_capabilities0.74261173
51MP0005377_hearing/vestibular/ear_phenot0.72748731
52MP0003878_abnormal_ear_physiology0.72748731
53MP0003077_abnormal_cell_cycle0.71451257
54MP0001905_abnormal_dopamine_level0.70996402
55MP0002557_abnormal_social/conspecific_i0.70580206
56MP0008058_abnormal_DNA_repair0.69736886
57MP0009046_muscle_twitch0.67974967
58MP0005666_abnormal_adipose_tissue0.66414033
59MP0003011_delayed_dark_adaptation0.64931968
60MP0004085_abnormal_heartbeat0.63978241
61MP0001879_abnormal_lymphatic_vessel0.62933631
62MP0002733_abnormal_thermal_nociception0.62698982
63MP0001666_abnormal_nutrient_absorption0.62113551
64MP0005636_abnormal_mineral_homeostasis0.61548178
65MP0000516_abnormal_urinary_system0.61373734
66MP0005367_renal/urinary_system_phenotyp0.61373734
67MP0002102_abnormal_ear_morphology0.61342346
68MP0005083_abnormal_biliary_tract0.59579293
69MP0002572_abnormal_emotion/affect_behav0.54412890
70MP0002272_abnormal_nervous_system0.51107626
71MP0009278_abnormal_bone_marrow0.50601182
72MP0001764_abnormal_homeostasis0.49856802
73MP0004484_altered_response_of0.49288035
74MP0009745_abnormal_behavioral_response0.49140471
75MP0001324_abnormal_eye_pigmentation0.48686689
76MP0004036_abnormal_muscle_relaxation0.48508332
77MP0003119_abnormal_digestive_system0.48050440
78MP0003329_amyloid_beta_deposits0.47650076
79MP0003699_abnormal_female_reproductive0.47531403
80MP0000569_abnormal_digit_pigmentation0.47177187
81MP0001293_anophthalmia0.47167577
82MP0000358_abnormal_cell_content/0.47138813
83MP0002734_abnormal_mechanical_nocicepti0.46933871
84MP0005397_hematopoietic_system_phenotyp0.46618762
85MP0001545_abnormal_hematopoietic_system0.46618762
86MP0000470_abnormal_stomach_morphology0.46099873
87MP0005535_abnormal_body_temperature0.45942870
88MP0003880_abnormal_central_pattern0.45490825
89MP0002269_muscular_atrophy0.44739898
90MP0000003_abnormal_adipose_tissue0.44178674
91MP0000534_abnormal_ureter_morphology0.43259992
92MP0010094_abnormal_chromosome_stability0.42317489
93MP0005167_abnormal_blood-brain_barrier0.41980194
94MP0001970_abnormal_pain_threshold0.41879229
95MP0005253_abnormal_eye_physiology0.41781143
96MP0002736_abnormal_nociception_after0.41771114
97MP0006036_abnormal_mitochondrial_physio0.41175814
98MP0003137_abnormal_impulse_conducting0.40361308
99MP0009115_abnormal_fat_cell0.39958761
100MP0001501_abnormal_sleep_pattern0.38499307
101MP0002254_reproductive_system_inflammat0.38485513
102MP0002928_abnormal_bile_duct0.38483911
103MP0005551_abnormal_eye_electrophysiolog0.38098435
104MP0003111_abnormal_nucleus_morphology0.37678970
105MP0003635_abnormal_synaptic_transmissio0.37664882
106MP0000613_abnormal_salivary_gland0.36949460
107MP0009697_abnormal_copulation0.35220030
108MP0003942_abnormal_urinary_system0.34229829
109MP0005394_taste/olfaction_phenotype0.34073260
110MP0005499_abnormal_olfactory_system0.34073260
111MP0006276_abnormal_autonomic_nervous0.33740363
112MP0001986_abnormal_taste_sensitivity0.33461286
113MP0003950_abnormal_plasma_membrane0.32728591
114MP0000249_abnormal_blood_vessel0.32299235
115MP0005391_vision/eye_phenotype0.31757855
116MP0003879_abnormal_hair_cell0.31719624
117MP0004133_heterotaxia0.30551526
118MP0002971_abnormal_brown_adipose0.30077609
119MP0004742_abnormal_vestibular_system0.28662484
120MP0001661_extended_life_span0.28530800
121MP0004811_abnormal_neuron_physiology0.28235161
122MP0001119_abnormal_female_reproductive0.25363675
123MP0004019_abnormal_vitamin_homeostasis0.25170000
124MP0002295_abnormal_pulmonary_circulatio0.24690931
125MP0008961_abnormal_basal_metabolism0.24410674
126MP0005375_adipose_tissue_phenotype0.24074668
127MP0003861_abnormal_nervous_system0.23902813
128MP0003948_abnormal_gas_homeostasis0.23575495
129MP0003633_abnormal_nervous_system0.23046914
130MP0002169_no_abnormal_phenotype0.22511367
131MP0002873_normal_phenotype0.22227308
132MP0001730_embryonic_growth_arrest0.21882877
133MP0003786_premature_aging0.21755927
134MP0004043_abnormal_pH_regulation0.21404312
135MP0002152_abnormal_brain_morphology0.20897199
136MP0000751_myopathy0.20536427
137MP0000604_amyloidosis0.20409813
138MP0001968_abnormal_touch/_nociception0.20240215
139MP0003045_fibrosis0.19819641
140MP0006035_abnormal_mitochondrial_morpho0.19469592
141MP0001727_abnormal_embryo_implantation0.19177768
142MP0001849_ear_inflammation0.19161637
143MP0003959_abnormal_lean_body0.18943868
144MP0003787_abnormal_imprinting0.18508346
145MP0002139_abnormal_hepatobiliary_system0.18477274
146MP0002108_abnormal_muscle_morphology0.17954683
147MP0004270_analgesia0.17548962
148MP0003631_nervous_system_phenotype0.16739292
149MP0002092_abnormal_eye_morphology0.16708277
150MP0008057_abnormal_DNA_replication0.16589475
151MP0008007_abnormal_cellular_replicative0.14904407
152MP0006072_abnormal_retinal_apoptosis0.14353991
153MP0003936_abnormal_reproductive_system0.13668000
154MP0000001_mammalian_phenotype0.13649309
155MP0000313_abnormal_cell_death0.13548010
156MP0002084_abnormal_developmental_patter0.13031765
157MP0002693_abnormal_pancreas_physiology0.12837527
158MP0001440_abnormal_grooming_behavior0.12603651
159MP0002796_impaired_skin_barrier0.12419017
160MP0002229_neurodegeneration0.11876839
161MP0005195_abnormal_posterior_eye0.11863022

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.20308115
2Abnormal respiratory epithelium morphology (HP:0012253)9.20308115
3Abnormal respiratory motile cilium physiology (HP:0012261)9.10095635
4Severe visual impairment (HP:0001141)8.37221779
5Rhinitis (HP:0012384)7.34598671
6Chronic bronchitis (HP:0004469)7.13283196
7Abnormal ciliary motility (HP:0012262)7.10046384
8Infertility (HP:0000789)7.04222052
9Nasal polyposis (HP:0100582)6.34495788
10Attenuation of retinal blood vessels (HP:0007843)5.34710408
11Bony spicule pigmentary retinopathy (HP:0007737)5.28305014
12Abnormality of the nasal mucosa (HP:0000433)5.21285818
13Male infertility (HP:0003251)4.95993765
14Resting tremor (HP:0002322)4.67634426
15Bronchitis (HP:0012387)4.51536182
16Hyperkalemia (HP:0002153)4.49303557
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.44110660
18Bronchiectasis (HP:0002110)4.35885789
19Chronic hepatic failure (HP:0100626)4.33965675
20Nephronophthisis (HP:0000090)4.30235180
21Abnormal rod and cone electroretinograms (HP:0008323)4.18529589
22Facial shape deformation (HP:0011334)4.06080482
23Potter facies (HP:0002009)4.06080482
24Abnormality of macular pigmentation (HP:0008002)4.03789201
25Abnormal spermatogenesis (HP:0008669)3.78640849
26Hypoplastic ischia (HP:0003175)3.69089835
27Cone-rod dystrophy (HP:0000548)3.64454163
28Enlarged epiphyses (HP:0010580)3.38653931
29Aplasia/Hypoplasia of the earlobes (HP:0009906)3.38000452
30Abnormality of the ischium (HP:0003174)3.28115371
31Recurrent otitis media (HP:0000403)3.25810771
32Abnormality of the renal medulla (HP:0100957)3.23011381
33Recurrent sinusitis (HP:0011108)3.21865690
34Postural instability (HP:0002172)3.15162299
35Progressive sensorineural hearing impairment (HP:0000408)3.11184760
36Hypoplasia of the thymus (HP:0000778)3.06044303
37Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.96281487
38Tubulointerstitial nephritis (HP:0001970)2.94196373
39Unilateral renal agenesis (HP:0000122)2.88186243
40Abnormality of the aortic arch (HP:0012303)2.87185000
41Impulsivity (HP:0100710)2.86023190
42Hypoalphalipoproteinemia (HP:0003233)2.81003822
43Recurrent bronchitis (HP:0002837)2.77038172
44Tubular atrophy (HP:0000092)2.70094131
45Generalized aminoaciduria (HP:0002909)2.67414663
46Progressive cerebellar ataxia (HP:0002073)2.57792836
47Abnormality of potassium homeostasis (HP:0011042)2.57052088
48Molar tooth sign on MRI (HP:0002419)2.55225775
49Abnormality of midbrain morphology (HP:0002418)2.55225775
50Tubulointerstitial abnormality (HP:0001969)2.54768912
51Abnormal gallbladder physiology (HP:0012438)2.54320573
52Cholecystitis (HP:0001082)2.54320573
53Gonadotropin excess (HP:0000837)2.50390868
54Abnormality of the costochondral junction (HP:0000919)2.47151062
55Amelogenesis imperfecta (HP:0000705)2.44093904
56Azoospermia (HP:0000027)2.36475319
57Renovascular hypertension (HP:0100817)2.33377322
58Abnormality of dental color (HP:0011073)2.32422517
59Portal hypertension (HP:0001409)2.29492750
60Dyschromatopsia (HP:0007641)2.29339662
61Insulin-resistant diabetes mellitus (HP:0000831)2.29104153
62Myokymia (HP:0002411)2.28661540
63Medial flaring of the eyebrow (HP:0010747)2.28183707
64Menstrual irregularities (HP:0000858)2.26826211
65Choroideremia (HP:0001139)2.24677450
66Abnormality of the parathyroid morphology (HP:0011766)2.19593178
67Osteomalacia (HP:0002749)2.16261847
68Hypophosphatemic rickets (HP:0004912)2.13675020
69Abnormality of the hepatic vasculature (HP:0006707)2.13157911
70Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08585668
71Tubulointerstitial fibrosis (HP:0005576)2.08227274
72Abnormality of the pubic bones (HP:0003172)2.06767558
73Tetany (HP:0001281)2.05486886
74Ventricular tachycardia (HP:0004756)2.04536582
75Progressive hearing impairment (HP:0001730)2.04218951
76Widely patent fontanelles and sutures (HP:0004492)2.02862055
77Flattened epiphyses (HP:0003071)2.02507070
78Epiphyseal dysplasia (HP:0002656)2.02009892
79Spastic tetraparesis (HP:0001285)2.01695720
80Dynein arm defect of respiratory motile cilia (HP:0012255)13.4188014
81Absent/shortened dynein arms (HP:0200106)13.4188014
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.7517582
83Hyponatremia (HP:0002902)1.99707753
84Abnormal drinking behavior (HP:0030082)1.98461744
85Polydipsia (HP:0001959)1.98461744
86Decreased central vision (HP:0007663)1.94260408
87Stage 5 chronic kidney disease (HP:0003774)1.88720475
88Heterotopia (HP:0002282)1.88022101
89Abnormality of the epiphysis of the femoral head (HP:0010574)1.86006635
90Abnormal ventriculo-arterial connection (HP:0011563)1.85391418
91Transposition of the great arteries (HP:0001669)1.85391418
92Abnormal connection of the cardiac segments (HP:0011545)1.85391418
93Renal Fanconi syndrome (HP:0001994)1.84447611
94Recurrent pneumonia (HP:0006532)1.83600055
95Postaxial foot polydactyly (HP:0001830)1.83446308
96Optic nerve hypoplasia (HP:0000609)1.82547268
97Peripheral hypomyelination (HP:0007182)1.81153100
98Hemorrhage of the eye (HP:0011885)1.81002522
99Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78218434
100Hypoparathyroidism (HP:0000829)1.78149624
101Increased purine levels (HP:0004368)1.77864479
102Hyperuricemia (HP:0002149)1.77864479
103Photophobia (HP:0000613)1.77006489
104Abnormality of renal excretion (HP:0011036)1.75194636
105Spastic paraparesis (HP:0002313)1.74251882
106Bell-shaped thorax (HP:0001591)1.72755635
107Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.72167622
108Abnormality of femoral epiphyses (HP:0006499)1.72167622
109Congenital hepatic fibrosis (HP:0002612)1.71734362
110Congenital malformation of the right heart (HP:0011723)1.67870207
111Double outlet right ventricle (HP:0001719)1.67870207
112Abnormality of the renal cortex (HP:0011035)1.67456837
113Bile duct proliferation (HP:0001408)1.62678954
114Abnormal biliary tract physiology (HP:0012439)1.62678954
115Decreased electroretinogram (ERG) amplitude (HP:0000654)1.57041828
116Neurofibrillary tangles (HP:0002185)1.56564021
117Short ribs (HP:0000773)1.56287073
118Oculomotor apraxia (HP:0000657)1.53970729
119Asymmetric septal hypertrophy (HP:0001670)1.49878158
120Abnormal urine output (HP:0012590)1.49440295
121Renal dysplasia (HP:0000110)1.47164428
122Taurodontia (HP:0000679)1.46750804
123Abnormality of permanent molar morphology (HP:0011071)1.46750804
124Abnormality of the dental root (HP:0006486)1.46750804
125Abnormality of the lower motor neuron (HP:0002366)1.45887521
126Abnormality of dentin (HP:0010299)1.42402089
127Aplasia/Hypoplasia of the lens (HP:0008063)1.42231828
128Postaxial hand polydactyly (HP:0001162)1.40831811
129Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.39773074
130Absent epiphyses (HP:0010577)1.39773074
131Facial cleft (HP:0002006)1.38888643
132Abnormality of the neuromuscular junction (HP:0003398)1.36590997
133Fatigable weakness (HP:0003473)1.36590997
134Abnormality of molar morphology (HP:0011070)1.35587228
135Abnormality of molar (HP:0011077)1.35587228
136Bundle branch block (HP:0011710)1.35499347
137Abnormality of the dental pulp (HP:0006479)1.35376407
138Fibular hypoplasia (HP:0003038)1.33665191
139Deformed sella turcica (HP:0002681)1.33439316
140Hemiparesis (HP:0001269)1.32077208
141Easy fatigability (HP:0003388)1.31601928
142Cerebral inclusion bodies (HP:0100314)1.28881517
143Cystic liver disease (HP:0006706)1.27123138
144Loss of speech (HP:0002371)1.26939256
145Truncal obesity (HP:0001956)1.26311079
146Broad distal phalanx of finger (HP:0009836)1.25379798
147Amyotrophic lateral sclerosis (HP:0007354)1.25162239
148Polyuria (HP:0000103)1.24493628
149Nephropathy (HP:0000112)1.23585368
150Short thorax (HP:0010306)1.22523519
151Absent frontal sinuses (HP:0002688)1.21819596
152Hypercholesterolemia (HP:0003124)1.21540020
153Exercise-induced myalgia (HP:0003738)1.20765104
154Short femoral neck (HP:0100864)1.20391141
155Cerebellar dysplasia (HP:0007033)1.19095865
156Impaired proprioception (HP:0010831)1.18934301
157Sensory axonal neuropathy (HP:0003390)1.18414321
158Chronic sinusitis (HP:0011109)1.18022362
159Myoglobinuria (HP:0002913)1.17268295
160Constricted visual fields (HP:0001133)1.16286776
161Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.13851973
162Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.12250049

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.62341108
2PDK47.62341108
3TESK17.06555452
4PRKD35.83209191
5PDK24.90809468
6ICK4.90653305
7DDR24.66648750
8MARK34.52122541
9INSRR3.33888773
10MAP4K23.26389465
11PLK22.86263846
12BRD42.80197140
13PTK2B2.32835974
14WNK42.03540781
15STK381.99651964
16PNCK1.99639456
17STK391.91648556
18MST1R1.74928352
19NEK21.69834102
20DYRK1B1.61712489
21PIK3CG1.45295818
22MAP3K91.39966519
23CDK71.39707326
24LATS21.37620706
25PDK11.19079036
26KSR21.13999617
27TYRO30.91301418
28DYRK30.89950609
29CAMK1D0.89212684
30MAPK150.88230962
31IRAK10.87635700
32WNK10.80845470
33SIK20.78824493
34PDPK10.77708737
35UHMK10.76134818
36AKT30.73940227
37PASK0.73363616
38TESK20.66720820
39EEF2K0.66546556
40CAMK1G0.65996671
41RIPK40.65790883
42RPS6KA20.65136236
43MAP3K110.62673930
44STK30.62008177
45MAP3K80.61547217
46TTK0.60648532
47MAP3K20.60184061
48MAP2K20.59988827
49MAP2K60.59263985
50PRKAA20.57946274
51PINK10.57120681
52CHEK20.57083864
53CCNB10.56933976
54IRAK20.53098646
55ROCK10.52517840
56LATS10.48291953
57CDK30.47997498
58BMPR1B0.46661974
59ARAF0.45456644
60MUSK0.44729117
61SGK2230.44412025
62SGK4940.44412025
63MAPK10.43763803
64PAK10.43239444
65NTRK30.40811855
66MAP3K10.39847611
67LMTK20.39819775
68NTRK20.39429366
69PRKCG0.39322781
70CHEK10.37233979
71STK38L0.36519277
72PAK20.35909458
73RPS6KC10.35444160
74RPS6KL10.35444160
75RPS6KA60.35267649
76CAMK40.34874709
77MTOR0.32459582
78SGK10.29784930
79MARK10.28949629
80MARK20.27462447
81ATM0.27319663
82MAP3K100.26397227
83MAPK140.25818827
84PAK40.25614898
85CAMKK10.25491483
86MAPK100.23588355
87MAPK110.22845277
88PLK40.22488025
89PRKAA10.22327560
90NEK60.22025820
91ATR0.21917287
92MAPKAPK50.19917936
93RPS6KB10.19411912
94PRKCZ0.18018437
95AKT10.17236024
96MET0.16508922
97OXSR10.16079012
98CDK190.16051703
99TLK10.15793063
100TNIK0.15003179
101TIE10.14155031
102CDC70.14047801
103ZAK0.13623801
104PRKCQ0.13349175
105BLK0.12292290
106MAP3K40.10879899
107PRKACB0.10866724
108RPS6KA10.10767996
109WEE10.10229076
110MAP3K130.09730641
111PLK10.09551002
112CSF1R0.09270549
113JAK30.09237963
114CDK150.08330746
115STK110.07767959
116BRSK10.07614561
117GSK3B0.07278511
118CDK180.05730700
119CSNK1D0.05720346
120CSNK2A10.05413580
121PRKG20.05075574
122CDK11A0.04959053
123BRSK20.04809017
124CDK120.04252458
125CDK60.04143897
126CAMK2A0.03901049
127CDK20.03205353
128PIM10.02947318
129BRAF0.02928871
130PRKCB0.02688702
131PRKACG0.02505659
132PRKCD0.02486290
133PKN10.02171743
134CLK10.01842591
135CDK10.01554252
136PRKG10.01467991
137CDK140.01308902
138STK100.01084931
139MAPK80.01065608
140PRKCA0.00465826
141TRIB3-0.0378162
142AURKA-0.0359927
143CAMK1-0.0346082
144PRKDC-0.0332570
145PRKACA-0.0287791
146ZAP70-0.0270482
147WNK3-0.0257851
148RPS6KA3-0.0257112
149EGFR-0.0221208
150EPHB1-0.0133611
151CSNK2A2-0.0082393
152CDK4-0.0059621
153PAK6-0.0006582

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.88424558
2Fatty acid biosynthesis_Homo sapiens_hsa000614.97518299
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.37677498
4Olfactory transduction_Homo sapiens_hsa047403.59618783
5Pyruvate metabolism_Homo sapiens_hsa006203.41366661
6Vitamin B6 metabolism_Homo sapiens_hsa007503.36383619
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.14580962
8Linoleic acid metabolism_Homo sapiens_hsa005913.02716454
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.70930516
10Propanoate metabolism_Homo sapiens_hsa006402.69114266
11Glucagon signaling pathway_Homo sapiens_hsa049222.56216129
12Butanoate metabolism_Homo sapiens_hsa006502.52384064
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.44087999
14Carbohydrate digestion and absorption_Homo sapiens_hsa049732.42694613
15Basal transcription factors_Homo sapiens_hsa030222.05003499
16Glycerolipid metabolism_Homo sapiens_hsa005612.04060109
17Selenocompound metabolism_Homo sapiens_hsa004502.02121676
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.00959539
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.97974551
20PPAR signaling pathway_Homo sapiens_hsa033201.91327100
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.74344520
22Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.65578505
23Type I diabetes mellitus_Homo sapiens_hsa049401.64236695
24Dorso-ventral axis formation_Homo sapiens_hsa043201.63651003
25Allograft rejection_Homo sapiens_hsa053301.63305657
26Autoimmune thyroid disease_Homo sapiens_hsa053201.59414199
27Oocyte meiosis_Homo sapiens_hsa041141.56760412
28Fructose and mannose metabolism_Homo sapiens_hsa000511.55405258
29Amphetamine addiction_Homo sapiens_hsa050311.53474392
30Graft-versus-host disease_Homo sapiens_hsa053321.51146819
31Fatty acid metabolism_Homo sapiens_hsa012121.51008574
32Fatty acid degradation_Homo sapiens_hsa000711.49861493
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.49645182
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45963196
35Fat digestion and absorption_Homo sapiens_hsa049751.45879915
36Mineral absorption_Homo sapiens_hsa049781.44714780
37Ether lipid metabolism_Homo sapiens_hsa005651.40632377
38Pentose phosphate pathway_Homo sapiens_hsa000301.32074102
39Phenylalanine metabolism_Homo sapiens_hsa003601.28652824
40Cardiac muscle contraction_Homo sapiens_hsa042601.27661640
41Carbon metabolism_Homo sapiens_hsa012001.22402096
42Arginine and proline metabolism_Homo sapiens_hsa003301.17545903
43Fanconi anemia pathway_Homo sapiens_hsa034601.16472669
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.13559269
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12773701
46Viral myocarditis_Homo sapiens_hsa054161.12139996
47Hedgehog signaling pathway_Homo sapiens_hsa043401.10360340
48Renin secretion_Homo sapiens_hsa049241.07767857
49Antigen processing and presentation_Homo sapiens_hsa046121.06412493
50Glutathione metabolism_Homo sapiens_hsa004801.01261303
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99342915
52mRNA surveillance pathway_Homo sapiens_hsa030150.96444034
53Purine metabolism_Homo sapiens_hsa002300.95519496
54Phototransduction_Homo sapiens_hsa047440.95427143
55Morphine addiction_Homo sapiens_hsa050320.92553551
56Insulin secretion_Homo sapiens_hsa049110.92208951
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91301186
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.87964475
59Arginine biosynthesis_Homo sapiens_hsa002200.86578925
60Collecting duct acid secretion_Homo sapiens_hsa049660.84851977
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84821412
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84638539
63Arachidonic acid metabolism_Homo sapiens_hsa005900.83859035
64Huntingtons disease_Homo sapiens_hsa050160.80978243
65RNA transport_Homo sapiens_hsa030130.79425477
66Influenza A_Homo sapiens_hsa051640.78736065
67Estrogen signaling pathway_Homo sapiens_hsa049150.74980704
68Long-term potentiation_Homo sapiens_hsa047200.74140972
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73707791
70Thyroid hormone synthesis_Homo sapiens_hsa049180.73298540
71Systemic lupus erythematosus_Homo sapiens_hsa053220.73231105
72Bile secretion_Homo sapiens_hsa049760.71722134
73Chemical carcinogenesis_Homo sapiens_hsa052040.70504547
74Nicotine addiction_Homo sapiens_hsa050330.70084062
75Biosynthesis of amino acids_Homo sapiens_hsa012300.69852037
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65790387
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.62260319
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61221108
79Calcium signaling pathway_Homo sapiens_hsa040200.58376864
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.57631047
81ABC transporters_Homo sapiens_hsa020100.57441636
82Acute myeloid leukemia_Homo sapiens_hsa052210.57228040
83Legionellosis_Homo sapiens_hsa051340.57138751
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53564328
85Protein digestion and absorption_Homo sapiens_hsa049740.53558392
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52996466
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.52154704
88MAPK signaling pathway_Homo sapiens_hsa040100.51013977
89Salivary secretion_Homo sapiens_hsa049700.50281413
90Tyrosine metabolism_Homo sapiens_hsa003500.49865092
91Pancreatic secretion_Homo sapiens_hsa049720.48822946
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48156797
93Inositol phosphate metabolism_Homo sapiens_hsa005620.48130560
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46984973
95Renin-angiotensin system_Homo sapiens_hsa046140.46374846
96Endocytosis_Homo sapiens_hsa041440.45638835
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45064768
98Glutamatergic synapse_Homo sapiens_hsa047240.44936506
99AMPK signaling pathway_Homo sapiens_hsa041520.44803287
100Tight junction_Homo sapiens_hsa045300.44151691
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43961691
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43845679
103Synaptic vesicle cycle_Homo sapiens_hsa047210.42229029
104Retinol metabolism_Homo sapiens_hsa008300.42021840
105Alcoholism_Homo sapiens_hsa050340.40814995
106Serotonergic synapse_Homo sapiens_hsa047260.39275872
107cAMP signaling pathway_Homo sapiens_hsa040240.39171397
108Cholinergic synapse_Homo sapiens_hsa047250.37222186
109Gastric acid secretion_Homo sapiens_hsa049710.36873553
110VEGF signaling pathway_Homo sapiens_hsa043700.34839013
111Taste transduction_Homo sapiens_hsa047420.34760551
112Metabolic pathways_Homo sapiens_hsa011000.33943071
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33520970
114Circadian entrainment_Homo sapiens_hsa047130.33057450
115GABAergic synapse_Homo sapiens_hsa047270.32012565
116Basal cell carcinoma_Homo sapiens_hsa052170.30965392
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30604433
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.30369412
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29928177
120Herpes simplex infection_Homo sapiens_hsa051680.28983760
121Oxytocin signaling pathway_Homo sapiens_hsa049210.28580546
122Nitrogen metabolism_Homo sapiens_hsa009100.27310607
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.26453156
124Cocaine addiction_Homo sapiens_hsa050300.21741255
125Sulfur metabolism_Homo sapiens_hsa009200.21286414
126Regulation of autophagy_Homo sapiens_hsa041400.20866622
127Prolactin signaling pathway_Homo sapiens_hsa049170.19929529
128Pyrimidine metabolism_Homo sapiens_hsa002400.19617856
129Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18842201
130Epstein-Barr virus infection_Homo sapiens_hsa051690.17979697
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.17544577
132Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17349110
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16613649
134Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.14704021
135Wnt signaling pathway_Homo sapiens_hsa043100.14098475
136HIF-1 signaling pathway_Homo sapiens_hsa040660.12643643
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.12215322
138B cell receptor signaling pathway_Homo sapiens_hsa046620.12124719
139Viral carcinogenesis_Homo sapiens_hsa052030.07751795
140Insulin resistance_Homo sapiens_hsa049310.07720598
141Type II diabetes mellitus_Homo sapiens_hsa049300.07605869

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