H1FOO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The related mouse gene is expressed only in oocytes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of meiosis (GO:0040020)8.48249457
2female gamete generation (GO:0007292)8.05825370
3mitotic chromosome condensation (GO:0007076)7.71954011
4retinal cone cell development (GO:0046549)7.68366000
5positive regulation of histone H3-K4 methylation (GO:0051571)7.60717531
6negative regulation of meiosis (GO:0045835)7.35152093
7multicellular organism reproduction (GO:0032504)7.22890239
8oocyte development (GO:0048599)7.00863478
9regulation of histone H3-K9 methylation (GO:0051570)6.91556732
10regulation of meiosis I (GO:0060631)6.85448824
11regulation of histone H3-K27 methylation (GO:0061085)6.83626004
12regulation of meiotic cell cycle (GO:0051445)6.74525591
13establishment of spindle orientation (GO:0051294)6.73745107
14attachment of spindle microtubules to kinetochore (GO:0008608)6.62610651
15establishment of spindle localization (GO:0051293)6.61746660
16protein localization to kinetochore (GO:0034501)6.46291065
17regulation of steroid hormone secretion (GO:2000831)6.42118804
18glycine transport (GO:0015816)6.40744169
19protein kinase C signaling (GO:0070528)6.15461739
20negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)6.04632757
21histone H2A monoubiquitination (GO:0035518)5.96129337
22mitotic metaphase plate congression (GO:0007080)5.89310580
23protein localization to chromosome, centromeric region (GO:0071459)5.54862810
24positive regulation of humoral immune response (GO:0002922)5.54269478
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.52277226
26regulation of retinoic acid receptor signaling pathway (GO:0048385)5.39357637
27regulation of metaphase/anaphase transition of cell cycle (GO:1902099)5.30474697
28regulation of cell maturation (GO:1903429)5.07533076
29histone H2A ubiquitination (GO:0033522)5.06447981
30metaphase plate congression (GO:0051310)5.05940606
31gene silencing by RNA (GO:0031047)4.96699638
32piRNA metabolic process (GO:0034587)4.91377720
33reproduction (GO:0000003)4.79625015
34L-amino acid import (GO:0043092)4.72554847
35maturation of 5.8S rRNA (GO:0000460)4.69742516
36protein localization to chromosome (GO:0034502)4.59156433
37positive regulation of histone methylation (GO:0031062)4.59071387
38positive regulation of gastrulation (GO:2000543)4.59000950
39folic acid-containing compound biosynthetic process (GO:0009396)4.56896759
40regulation of steroid hormone biosynthetic process (GO:0090030)4.56409409
41negative regulation of histone methylation (GO:0031061)4.55269757
42* meiotic cell cycle (GO:0051321)4.52641019
43regulation of mitotic spindle organization (GO:0060236)4.45768354
44regulation of histone H3-K4 methylation (GO:0051569)4.44391468
45positive regulation of reproductive process (GO:2000243)4.37619536
46mitotic sister chromatid segregation (GO:0000070)4.36183566
47establishment of chromosome localization (GO:0051303)4.33279315
48base-excision repair, AP site formation (GO:0006285)4.28778934
49protein K6-linked ubiquitination (GO:0085020)4.28207424
50negative regulation of DNA-templated transcription, elongation (GO:0032785)4.26433498
51negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.26433498
52positive regulation of uterine smooth muscle contraction (GO:0070474)4.26149122
53positive regulation of chromosome segregation (GO:0051984)4.20378822
54centriole replication (GO:0007099)4.19145870
55phosphorelay signal transduction system (GO:0000160)4.18396798
56CENP-A containing nucleosome assembly (GO:0034080)4.16814218
57oocyte maturation (GO:0001556)4.16407805
58regulation of histone methylation (GO:0031060)4.12866525
59chromatin remodeling at centromere (GO:0031055)4.02698055
60synapsis (GO:0007129)4.01603300
61primitive streak formation (GO:0090009)3.96174733
62phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.93864634
63binding of sperm to zona pellucida (GO:0007339)3.91460176
64positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.90600933
65positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.90600933
66positive regulation of mitotic sister chromatid separation (GO:1901970)3.90600933
67negative regulation of hormone biosynthetic process (GO:0032353)3.90010592
68one-carbon metabolic process (GO:0006730)3.89737741
69chromosome segregation (GO:0007059)3.87776340
70regulation of sister chromatid cohesion (GO:0007063)3.84426863
71negative regulation of hormone metabolic process (GO:0032351)3.81555097
72histone exchange (GO:0043486)3.80574537
73negative regulation of reproductive process (GO:2000242)3.78896196
74kinetochore organization (GO:0051383)3.78466064
75stress granule assembly (GO:0034063)3.75059620
76DNA replication-independent nucleosome assembly (GO:0006336)3.74943861
77DNA replication-independent nucleosome organization (GO:0034724)3.74943861
78fertilization (GO:0009566)3.74864106
79regulation of spindle organization (GO:0090224)3.71314681
80regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.71073316
81male meiosis I (GO:0007141)3.68196665
82DNA damage induced protein phosphorylation (GO:0006975)3.66764139
83mitotic nuclear envelope disassembly (GO:0007077)3.66511925
84membrane tubulation (GO:0097320)3.65296568
85DNA replication-dependent nucleosome organization (GO:0034723)3.65032157
86DNA replication-dependent nucleosome assembly (GO:0006335)3.65032157
87DNA methylation (GO:0006306)3.62774603
88DNA alkylation (GO:0006305)3.62774603
89microtubule nucleation (GO:0007020)3.62495872
90single fertilization (GO:0007338)3.59422703
91translesion synthesis (GO:0019985)3.57786901
92regulation of RNA export from nucleus (GO:0046831)3.57566004
93negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.56323650
94sister chromatid segregation (GO:0000819)3.55118823
95spindle checkpoint (GO:0031577)3.53812561
96positive regulation of megakaryocyte differentiation (GO:0045654)3.53566296
97kinetochore assembly (GO:0051382)3.51003367
98pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.47903884
99gene silencing (GO:0016458)3.47870401
100membrane disassembly (GO:0030397)3.46735126
101nuclear envelope disassembly (GO:0051081)3.46735126
102cellular response to pH (GO:0071467)3.45931788
103negative regulation of histone modification (GO:0031057)3.43313354
104regulation of cytokine production involved in inflammatory response (GO:1900015)3.42280908
105regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.41559804
106citrulline biosynthetic process (GO:0019240)3.41479702
107negative regulation of nuclear division (GO:0051784)3.41218760
108DNA replication checkpoint (GO:0000076)3.40781753
109type B pancreatic cell development (GO:0003323)3.40633213
110regulation of corticosteroid hormone secretion (GO:2000846)3.39789583
111N-terminal protein amino acid acetylation (GO:0006474)3.38198083
112oogenesis (GO:0048477)3.37881437
113aggressive behavior (GO:0002118)3.37873124
114* regulation of DNA methylation (GO:0044030)3.35650170
115chaperone-mediated protein transport (GO:0072321)3.35383699
116hyperosmotic salinity response (GO:0042538)3.34815501
117mitotic spindle checkpoint (GO:0071174)3.33668559
118glycerophospholipid catabolic process (GO:0046475)3.33019555
119positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.31745608
120positive regulation of hormone biosynthetic process (GO:0046886)3.30952197
121meiotic chromosome segregation (GO:0045132)3.29392708
122notochord development (GO:0030903)3.28667481
123regulation of autophagic vacuole assembly (GO:2000785)3.28404117
124regulation of calcium ion-dependent exocytosis (GO:0017158)3.27794251
125amino acid import (GO:0043090)3.25261604
126positive regulation of Cdc42 GTPase activity (GO:0043089)3.24937331
127labyrinthine layer development (GO:0060711)3.22531744
128regulation of exit from mitosis (GO:0007096)3.22312320
129histone phosphorylation (GO:0016572)3.21869324
130regulation of uterine smooth muscle contraction (GO:0070472)3.20232282
131negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001240)3.20083475
132negative regulation of signal transduction in absence of ligand (GO:1901099)3.20083475
133interkinetic nuclear migration (GO:0022027)3.19933487
134regulation of spindle checkpoint (GO:0090231)3.19811585
135cytoskeleton-dependent cytokinesis (GO:0061640)3.19524452
136negative regulation of chromosome segregation (GO:0051985)3.19518054
137regulation of reproductive process (GO:2000241)3.19405995
138regulation of G2/M transition of mitotic cell cycle (GO:0010389)3.18998818
139regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.15373535
140regulation of chromatin silencing (GO:0031935)3.14293123
141meiosis I (GO:0007127)3.13991163
142regulation of female receptivity (GO:0045924)3.13615170
143sperm-egg recognition (GO:0035036)3.13515759
144positive regulation of DNA-dependent DNA replication (GO:2000105)3.13508071
145response to acidic pH (GO:0010447)3.13128135
146DNA methylation involved in gamete generation (GO:0043046)3.12987421
147DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.12916562
148male meiosis (GO:0007140)3.08754656
149regulation of chromosome segregation (GO:0051983)3.08405196
150regulation of acrosome reaction (GO:0060046)3.06585874
151nuclear envelope organization (GO:0006998)3.06051650
152erythrocyte development (GO:0048821)3.05689558
153negative regulation of execution phase of apoptosis (GO:1900118)3.05160119
154negative regulation of cell division (GO:0051782)3.02187053
155muscle cell migration (GO:0014812)3.02149861
156mitotic spindle assembly checkpoint (GO:0007094)3.01263657
157chromosome condensation (GO:0030261)3.00706974
158folic acid metabolic process (GO:0046655)2.99944120
159cytoplasmic mRNA processing body assembly (GO:0033962)2.99756991
160negative regulation of mitotic sister chromatid separation (GO:2000816)2.99271020
161negative regulation of mitotic sister chromatid segregation (GO:0033048)2.99271020
162negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.99271020
163negative regulation of sister chromatid segregation (GO:0033046)2.99271020
164regulation of mitotic sister chromatid separation (GO:0010965)2.96393267
165regulation of mitotic sister chromatid segregation (GO:0033047)2.96393267
166regulation of sister chromatid segregation (GO:0033045)2.96393267
167regulation of nuclear division (GO:0051783)2.95917249
168regulation of female gonad development (GO:2000194)13.2265240
169negative regulation of meiotic cell cycle (GO:0051447)10.2386730

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.89145324
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.86407814
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.18294752
4AR_21909140_ChIP-Seq_LNCAP_Human3.91981468
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.71002505
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.60443269
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.44911823
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.41620332
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.41620332
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.41620332
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.40549259
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.31396242
13SMAD_19615063_ChIP-ChIP_OVARY_Human3.19389855
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.04816044
15E2F7_22180533_ChIP-Seq_HELA_Human2.82249478
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.60655769
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.50249443
18RUNX1_26923725_Chip-Seq_HPCs_Mouse2.49575005
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.41712937
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34737249
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.32493808
22KAP1_22055183_ChIP-Seq_ESCs_Mouse2.26461260
23GATA1_26923725_Chip-Seq_HPCs_Mouse2.14149649
24MYC_18940864_ChIP-ChIP_HL60_Human2.11308246
25MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse2.08489905
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05779585
27HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.01521512
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89547479
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.85211341
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83542041
31GBX2_23144817_ChIP-Seq_PC3_Human1.80897100
32EZH2_22144423_ChIP-Seq_EOC_Human1.79329973
33ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.76865144
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69769419
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.67237838
36CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54427629
37FOXM1_26456572_ChIP-Seq_MCF-7_Human1.52308107
38ELK4_26923725_Chip-Seq_MESODERM_Mouse1.49030837
39TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.43499093
40FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.36668510
41BP1_19119308_ChIP-ChIP_Hs578T_Human1.35877824
42ESR1_15608294_ChIP-ChIP_MCF-7_Human1.34276236
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.31178758
44NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31015430
45SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.29715709
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29712767
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.28905861
48GF1B_26923725_Chip-Seq_HPCs_Mouse1.28454247
49TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25556458
50ESR1_21235772_ChIP-Seq_MCF-7_Human1.23060011
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22317680
52SMRT_27268052_Chip-Seq_Bcells_Human1.18985271
53* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16403475
54BCAT_22108803_ChIP-Seq_LS180_Human1.15039388
55EWS_26573619_Chip-Seq_HEK293_Human1.13066865
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12741917
57LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12370484
58NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.12324647
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.11880774
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10666860
61ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10341799
62TCF4_23295773_ChIP-Seq_U87_Human1.10316415
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09655362
64SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09501285
65RNF2_27304074_Chip-Seq_NSC_Mouse1.09459215
66CDX2_22108803_ChIP-Seq_LS180_Human1.09129339
67PRDM14_20953172_ChIP-Seq_ESCs_Human1.08618317
68OCT1_27270436_Chip-Seq_PROSTATE_Human1.08611023
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08361157
70NANOG_21062744_ChIP-ChIP_HESCs_Human1.06460548
71SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05140673
72CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04784036
73TP63_23658742_ChIP-Seq_EP156T_Human1.04437693
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03449692
75FUS_26573619_Chip-Seq_HEK293_Human1.02599490
76STAT3_23295773_ChIP-Seq_U87_Human1.02037711
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.01365489
78CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00170070
79TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99228515
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98740479
81ERG_20517297_ChIP-Seq_VCAP_Human0.98218049
82MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.98005350
83SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97730615
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97333154
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96012389
86GATA3_21867929_ChIP-Seq_TH1_Mouse0.95200263
87GF1_26923725_Chip-Seq_HPCs_Mouse0.94631046
88TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94075487
89SMAD4_21799915_ChIP-Seq_A2780_Human0.93859084
90* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93401092
91* CBP_20019798_ChIP-Seq_JUKART_Human0.93401092
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93059708
93RUNX2_22187159_ChIP-Seq_PCA_Human0.92957331
94VDR_22108803_ChIP-Seq_LS180_Human0.92906676
95IRF1_19129219_ChIP-ChIP_H3396_Human0.92762092
96FOXH1_21741376_ChIP-Seq_EPCs_Human0.92292587
97STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91957757
98EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91556575
99NANOG_20526341_ChIP-Seq_ESCs_Human0.90780416
100AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90645330
101SMAD4_21741376_ChIP-Seq_EPCs_Human0.90551593
102* AR_25329375_ChIP-Seq_VCAP_Human0.90054633
103PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89604085
104GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88860607
105RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88085557
106BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86093971
107NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.85708800
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85416965
109MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.85359707
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85177526
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85177526
112LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84616272
113* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.84466595
114KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.83427501
115NFYA_21822215_ChIP-Seq_K562_Human0.83031524
116P53_22127205_ChIP-Seq_FIBROBLAST_Human0.82409292
117FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82362696
118CBP_21632823_ChIP-Seq_H3396_Human0.82017775
119FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.81020408
120WT1_25993318_ChIP-Seq_PODOCYTE_Human0.80268684
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79128231
122KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.78871498
123SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.77389480
124RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.77344760
125GATA3_26560356_Chip-Seq_TH1_Human0.77013217
126ZNF274_21170338_ChIP-Seq_K562_Hela0.76508459
127STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.76000406
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.75903991
129ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75736795
130CJUN_26792858_Chip-Seq_BT549_Human0.75157108
131E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.75082132
132EZH2_27304074_Chip-Seq_ESCs_Mouse0.73306604
133NANOG_18555785_ChIP-Seq_MESCs_Mouse0.72681086
134WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.72375387
135AHR_22903824_ChIP-Seq_MCF-7_Human0.72085640
136MYC_22102868_ChIP-Seq_BL_Human0.71713400
137* TBX20_22328084_ChIP-Seq_HEART_Mouse0.71353626
138* TBX20_22080862_ChIP-Seq_HEART_Mouse0.71353626
139TAL1_26923725_Chip-Seq_HPCs_Mouse0.71203970
140PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.70786644
141KLF4_19829295_ChIP-Seq_ESCs_Human0.70770295
142HTT_18923047_ChIP-ChIP_STHdh_Human0.70042425
143SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.69876435
144DROSHA_22980978_ChIP-Seq_HELA_Human0.69186818
145FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.68039623
146PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.66662350
147TP53_22573176_ChIP-Seq_HFKS_Human0.65599311
148SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.65464397
149KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.65210716
150REST_21632747_ChIP-Seq_MESCs_Mouse0.65018105
151* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.64383596
152TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.62507209
153SALL4_22934838_ChIP-ChIP_CD34+_Human0.60702467
154SMAD3_21741376_ChIP-Seq_EPCs_Human0.60281761
155FOXP3_21729870_ChIP-Seq_TREG_Human0.59944200
156PKCTHETA_26484144_Chip-Seq_BREAST_Human0.58135616
157CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.56279429
158SMAD3_21741376_ChIP-Seq_ESCs_Human0.55179403
159BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.54434566

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect8.41253152
2MP0005451_abnormal_body_composition7.89117669
3MP0002653_abnormal_ependyma_morphology4.49833331
4MP0005395_other_phenotype3.74258567
5MP0008057_abnormal_DNA_replication3.69642246
6MP0008789_abnormal_olfactory_epithelium3.60719215
7MP0003646_muscle_fatigue3.46659371
8MP0005499_abnormal_olfactory_system3.38170048
9MP0005394_taste/olfaction_phenotype3.38170048
10MP0003699_abnormal_female_reproductive3.24678301
11MP0010094_abnormal_chromosome_stability3.11457264
12MP0001119_abnormal_female_reproductive3.09276636
13MP0002138_abnormal_hepatobiliary_system2.85938686
14MP0003111_abnormal_nucleus_morphology2.82477085
15MP0003879_abnormal_hair_cell2.82017806
16MP0003077_abnormal_cell_cycle2.64285397
17MP0003693_abnormal_embryo_hatching2.59597062
18MP0004264_abnormal_extraembryonic_tissu2.34629867
19MP0010030_abnormal_orbit_morphology2.33497462
20MP0003705_abnormal_hypodermis_morpholog2.32951636
21MP0002102_abnormal_ear_morphology2.30736254
22MP0005408_hypopigmentation2.20575699
23MP0008877_abnormal_DNA_methylation2.19026809
24MP0001915_intracranial_hemorrhage2.16914143
25MP0000653_abnormal_sex_gland2.11218512
26MP0008058_abnormal_DNA_repair2.09224819
27MP0004859_abnormal_synaptic_plasticity2.06526153
28MP0002234_abnormal_pharynx_morphology2.02935810
29MP0001929_abnormal_gametogenesis2.00150208
30MP0004510_myositis1.93185146
31MP0004957_abnormal_blastocyst_morpholog1.88970148
32MP0003183_abnormal_peptide_metabolism1.87680904
33MP0006072_abnormal_retinal_apoptosis1.86257926
34MP0009840_abnormal_foam_cell1.79270806
35MP0010234_abnormal_vibrissa_follicle1.78763314
36MP0000566_synostosis1.76239940
37MP0002210_abnormal_sex_determination1.65555974
38MP0002161_abnormal_fertility/fecundity1.65517973
39MP0010307_abnormal_tumor_latency1.58228638
40MP0001529_abnormal_vocalization1.55492829
41MP0001849_ear_inflammation1.50469151
42MP0005646_abnormal_pituitary_gland1.49604548
43MP0005410_abnormal_fertilization1.46967040
44MP0002295_abnormal_pulmonary_circulatio1.44702342
45MP0001905_abnormal_dopamine_level1.41176532
46MP0009379_abnormal_foot_pigmentation1.38425390
47MP0003950_abnormal_plasma_membrane1.37296974
48MP0001293_anophthalmia1.35392825
49MP0002160_abnormal_reproductive_system1.33703755
50MP0000350_abnormal_cell_proliferation1.33049325
51MP0001986_abnormal_taste_sensitivity1.32694451
52MP0008932_abnormal_embryonic_tissue1.28751311
53MP0001485_abnormal_pinna_reflex1.23708516
54MP0004142_abnormal_muscle_tone1.23481005
55MP0005310_abnormal_salivary_gland1.20619134
56MP0003937_abnormal_limbs/digits/tail_de1.19924545
57MP0010368_abnormal_lymphatic_system1.18390516
58MP0000762_abnormal_tongue_morphology1.17313215
59MP0004185_abnormal_adipocyte_glucose1.15948109
60MP0003453_abnormal_keratinocyte_physiol1.11608025
61MP0008260_abnormal_autophagy1.10781469
62MP0000579_abnormal_nail_morphology1.09279499
63MP0006276_abnormal_autonomic_nervous1.08586627
64MP0002019_abnormal_tumor_incidence1.08553602
65MP0002233_abnormal_nose_morphology1.07566955
66MP0003698_abnormal_male_reproductive1.03857114
67MP0002932_abnormal_joint_morphology1.02416646
68MP0003136_yellow_coat_color1.01268641
69MP0002272_abnormal_nervous_system1.00301699
70MP0008007_abnormal_cellular_replicative0.99357702
71MP0005389_reproductive_system_phenotype0.99100376
72MP0003890_abnormal_embryonic-extraembry0.97117385
73MP0005023_abnormal_wound_healing0.96621125
74MP0000639_abnormal_adrenal_gland0.95784494
75MP0005360_urolithiasis0.94975367
76MP0001664_abnormal_digestion0.91797661
77MP0000427_abnormal_hair_cycle0.91738722
78MP0008875_abnormal_xenobiotic_pharmacok0.89833016
79MP0005647_abnormal_sex_gland0.86771908
80MP0001730_embryonic_growth_arrest0.86474971
81MP0005085_abnormal_gallbladder_physiolo0.86375061
82MP0002085_abnormal_embryonic_tissue0.85922063
83MP0003119_abnormal_digestive_system0.85272353
84MP0003121_genomic_imprinting0.80708539
85MP0001697_abnormal_embryo_size0.80560179
86MP0001145_abnormal_male_reproductive0.80082245
87MP0002084_abnormal_developmental_patter0.77372115
88MP0002933_joint_inflammation0.76356289
89MP0000049_abnormal_middle_ear0.75926358
90MP0005551_abnormal_eye_electrophysiolog0.74987092
91MP0010352_gastrointestinal_tract_polyps0.74703675
92MP0003941_abnormal_skin_development0.74547133
93MP0000678_abnormal_parathyroid_gland0.73290460
94MP0005621_abnormal_cell_physiology0.73147487
95MP0002127_abnormal_cardiovascular_syste0.71693775
96MP0003868_abnormal_feces_composition0.70849443
97MP0001324_abnormal_eye_pigmentation0.68258021
98MP0005197_abnormal_uvea_morphology0.67559213
99MP0001984_abnormal_olfaction0.67348050
100MP0010678_abnormal_skin_adnexa0.66053056
101MP0000015_abnormal_ear_pigmentation0.65854157
102MP0001963_abnormal_hearing_physiology0.63910099
103MP0004145_abnormal_muscle_electrophysio0.63123667
104MP0002089_abnormal_postnatal_growth/wei0.61986205
105MP0005501_abnormal_skin_physiology0.61380466
106MP0002796_impaired_skin_barrier0.61232413
107MP0002177_abnormal_outer_ear0.60652795
108MP0001502_abnormal_circadian_rhythm0.60295447
109MP0001672_abnormal_embryogenesis/_devel0.60229418
110MP0005380_embryogenesis_phenotype0.60229418
111MP0003329_amyloid_beta_deposits0.59355179
112MP0002139_abnormal_hepatobiliary_system0.57074236
113MP0000751_myopathy0.56727074
114MP0001919_abnormal_reproductive_system0.56131563
115MP0001881_abnormal_mammary_gland0.54101750
116MP0005075_abnormal_melanosome_morpholog0.54018109
117MP0003763_abnormal_thymus_physiology0.53909048
118MP0009384_cardiac_valve_regurgitation0.53160292
119MP0003566_abnormal_cell_adhesion0.51958264
120MP0009697_abnormal_copulation0.50088407
121MP0004381_abnormal_hair_follicle0.49029923
122MP0001944_abnormal_pancreas_morphology0.48035358
123MP0001346_abnormal_lacrimal_gland0.47925440
124MP0003315_abnormal_perineum_morphology0.47714257
125MP0002168_other_aberrant_phenotype0.47437889
126MP0000631_abnormal_neuroendocrine_gland0.46419119
127MP0010386_abnormal_urinary_bladder0.46026929
128MP0005319_abnormal_enzyme/_coenzyme0.45925522
129MP0003632_abnormal_nervous_system0.45920331
130MP0005670_abnormal_white_adipose0.45707575
131MP0005076_abnormal_cell_differentiation0.45545877
132MP0002269_muscular_atrophy0.45417511
133MP0008004_abnormal_stomach_pH0.43383471
134MP0003959_abnormal_lean_body0.43243106
135MP0002735_abnormal_chemical_nociception0.43224915
136MP0003075_altered_response_to0.43028323
137MP0002249_abnormal_larynx_morphology0.42815432
138MP0004043_abnormal_pH_regulation0.41305884
139MP0003984_embryonic_growth_retardation0.41248720
140MP0005503_abnormal_tendon_morphology0.41113164
141MP0005384_cellular_phenotype0.40577913
142MP0003755_abnormal_palate_morphology0.40140078
143MP0008995_early_reproductive_senescence0.39898924
144MP0003195_calcinosis0.39774367
145MP0003935_abnormal_craniofacial_develop0.39704882
146MP0002734_abnormal_mechanical_nocicepti0.39666862
147MP0004233_abnormal_muscle_weight0.39494984
148MP0001756_abnormal_urination0.38723437
149MP0009763_increased_sensitivity_to0.38430896
150MP0000428_abnormal_craniofacial_morphol0.38079082
151MP0003252_abnormal_bile_duct0.37789085
152MP0002928_abnormal_bile_duct0.37720974
153MP0002088_abnormal_embryonic_growth/wei0.37667175
154MP0003861_abnormal_nervous_system0.37033014
155MP0000733_abnormal_muscle_development0.36949256
156MP0004484_altered_response_of0.36716977
157MP0006292_abnormal_olfactory_placode0.36686183
158MP0001666_abnormal_nutrient_absorption0.34579493
159MP0002080_prenatal_lethality0.34517030
160MP0000477_abnormal_intestine_morphology0.34343151

Predicted human phenotypes

RankGene SetZ-score
1Cholecystitis (HP:0001082)9.70413662
2Abnormal gallbladder physiology (HP:0012438)9.70413662
3Deep venous thrombosis (HP:0002625)7.13508643
4Osteomalacia (HP:0002749)5.42226141
5Abnormality of abdominal situs (HP:0011620)5.08033863
6Abdominal situs inversus (HP:0003363)5.08033863
7Lip pit (HP:0100267)5.00944422
8Impulsivity (HP:0100710)4.99200490
9Birth length less than 3rd percentile (HP:0003561)4.98200911
10Hypophosphatemic rickets (HP:0004912)4.87671980
11Hypoplasia of the fovea (HP:0007750)4.85881061
12Aplasia/Hypoplasia of the fovea (HP:0008060)4.85881061
13Anterior segment dysgenesis (HP:0007700)4.63685364
14Breast hypoplasia (HP:0003187)4.49381150
15Supernumerary spleens (HP:0009799)4.45099549
16Rhabdomyosarcoma (HP:0002859)4.41845525
17Aplasia/Hypoplasia of the sternum (HP:0006714)4.29945350
18Abnormality of the fovea (HP:0000493)4.05708474
19Infertility (HP:0000789)4.01346238
20Septo-optic dysplasia (HP:0100842)3.67873176
21Azoospermia (HP:0000027)3.67409744
22Apathy (HP:0000741)3.62009063
23Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.59487265
24Hypokinesia (HP:0002375)3.57679185
25Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.57146597
26Short 1st metacarpal (HP:0010034)3.57146597
27Combined immunodeficiency (HP:0005387)3.51341947
28Diminished motivation (HP:0000745)3.51240400
29Median cleft lip (HP:0000161)3.40180235
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.39440540
31Neoplasm of striated muscle (HP:0009728)3.28466969
32Cholelithiasis (HP:0001081)3.25593313
33Chromsome breakage (HP:0040012)3.22381171
34Abnormality of the labia minora (HP:0012880)3.18516275
35Adrenal hypoplasia (HP:0000835)3.18389407
36Spinal cord compression (HP:0002176)3.11500294
37Papillary thyroid carcinoma (HP:0002895)3.09440674
38Abnormality of the 1st metacarpal (HP:0010009)3.07428700
39Aplasia/Hypoplasia of the macula (HP:0008059)3.07423226
40Abnormal gallbladder morphology (HP:0012437)3.04716158
41Muscle stiffness (HP:0003552)3.04430167
42Premature ovarian failure (HP:0008209)3.04256906
43Gonadotropin excess (HP:0000837)3.04165117
44Cortical dysplasia (HP:0002539)3.00077670
45Absent septum pellucidum (HP:0001331)2.95819830
46Urethral obstruction (HP:0000796)2.84891343
47Truncal obesity (HP:0001956)2.83020823
48Lower limb hyperreflexia (HP:0002395)2.82431713
49Arterial tortuosity (HP:0005116)2.81934646
50Aplasia/Hypoplasia affecting the retina (HP:0008061)2.80916098
51Aplasia of the musculature (HP:0100854)2.79145736
52Abnormal spermatogenesis (HP:0008669)2.78363266
53Short tibia (HP:0005736)2.76080529
54Loss of speech (HP:0002371)2.73444289
55Secondary amenorrhea (HP:0000869)2.71714967
56Conjunctival telangiectasia (HP:0000524)2.71493112
57Chronic bronchitis (HP:0004469)2.70870271
58Skin pits (HP:0100276)2.70397173
59Short phalanx of the thumb (HP:0009660)2.69336536
60Posterior subcapsular cataract (HP:0007787)2.66664704
61Myokymia (HP:0002411)2.65311157
62Abnormality of lateral ventricle (HP:0030047)2.65041453
63Metaphyseal irregularity (HP:0003025)2.64097849
64Generalized aminoaciduria (HP:0002909)2.61810812
65Abnormality of chromosome segregation (HP:0002916)2.60231709
66Overlapping toe (HP:0001845)2.58751360
67Patellar aplasia (HP:0006443)2.47796375
68Chromosomal breakage induced by crosslinking agents (HP:0003221)2.46796936
69Abnormality of the septum pellucidum (HP:0007375)2.44934859
70Fetal akinesia sequence (HP:0001989)2.44783831
71Fibular aplasia (HP:0002990)2.44602379
72Vascular tortuosity (HP:0004948)2.42817873
73Aplasia/Hypoplasia involving the musculature (HP:0001460)2.42678549
74Sandal gap (HP:0001852)2.42414161
75Proximal tubulopathy (HP:0000114)2.41761595
76Oligodactyly (HP:0012165)2.41273364
77Aplasia/Hypoplasia of the tibia (HP:0005772)2.40910837
78Abnormality of the proximal phalanges of the hand (HP:0009834)2.39657026
79Uterine leiomyosarcoma (HP:0002891)2.39518345
80Leiomyosarcoma (HP:0100243)2.39518345
81Diastasis recti (HP:0001540)2.39502827
82Thyroid carcinoma (HP:0002890)2.38979414
83Nephroblastoma (Wilms tumor) (HP:0002667)2.36966162
84Dysdiadochokinesis (HP:0002075)2.32506471
85Sex reversal (HP:0012245)2.30444741
86Abnormal sex determination (HP:0012244)2.30444741
87Hypergonadotropic hypogonadism (HP:0000815)2.29404081
88Increased circulating renin level (HP:0000848)2.24740187
89Intrahepatic cholestasis (HP:0001406)2.24188397
90Shawl scrotum (HP:0000049)2.23420117
91Abnormality of placental membranes (HP:0011409)2.21728667
92Amniotic constriction ring (HP:0009775)2.21728667
93Aplasia/Hypoplasia of the patella (HP:0006498)2.20806771
94Bundle branch block (HP:0011710)2.18905740
95Subcapsular cataract (HP:0000523)2.18832374
96Anhidrosis (HP:0000970)2.18744829
97Embryonal renal neoplasm (HP:0011794)2.17963165
98Abnormality of calcium-phosphate metabolism (HP:0100530)2.16187292
99Anomalous pulmonary venous return (HP:0010772)2.15412715
100Rib fusion (HP:0000902)2.14444166
101Aplasia involving bones of the upper limbs (HP:0009823)2.13608699
102Aplasia of the phalanges of the hand (HP:0009802)2.13608699
103Aplasia involving bones of the extremities (HP:0009825)2.13608699
104Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.12381707
105Congenital sensorineural hearing impairment (HP:0008527)2.12376507
106Hypercortisolism (HP:0001578)2.11586368
107Aplasia/Hypoplasia of the breasts (HP:0010311)2.11352663
108Abnormality of the vasculature of the conjunctiva (HP:0008054)2.11058701
109Breast aplasia (HP:0100783)2.10666664
110Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.10137509
111Duodenal stenosis (HP:0100867)2.04568854
112Small intestinal stenosis (HP:0012848)2.04568854
113Chin dimple (HP:0010751)2.04377407
114Sensory axonal neuropathy (HP:0003390)2.03869545
115Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.03380796
116Aplasia/Hypoplasia of the tongue (HP:0010295)2.02297606
117Abnormality of the gallbladder (HP:0005264)2.02088467
118Abnormal biliary tract physiology (HP:0012439)2.00848722
119Bile duct proliferation (HP:0001408)2.00848722
120Male infertility (HP:0003251)10.0170910
121Nausea (HP:0002018)1.99487190
122Transitional cell carcinoma of the bladder (HP:0006740)1.99380198
123Abnormality of the intervertebral disk (HP:0005108)1.99259473
124Striae distensae (HP:0001065)1.99197641
125Abnormality of monocarboxylic acid metabolism (HP:0010996)1.98690366
126Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.98401478
127Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.98361309
128Abnormality of the anterior chamber (HP:0000593)1.96678324
129Hypoplastic iliac wings (HP:0002866)1.95751121
130Capillary hemangiomas (HP:0005306)1.95645909
131Stenosis of the external auditory canal (HP:0000402)1.94245143
132Malnutrition (HP:0004395)1.93157766
133Microglossia (HP:0000171)1.93025032
134Pulmonary fibrosis (HP:0002206)1.92860691
135Rickets (HP:0002748)1.92658515
136Insulin-resistant diabetes mellitus (HP:0000831)1.92001032
137Abnormal lung lobation (HP:0002101)1.91480328
138Heterotopia (HP:0002282)1.91001668
139Cerebral hypomyelination (HP:0006808)1.90129833
140Maternal diabetes (HP:0009800)1.89948911
141Abnormal ciliary motility (HP:0012262)1.89700859
142Enlarged penis (HP:0000040)1.88101778
143Cranial hyperostosis (HP:0004437)1.85470397
144Flat capital femoral epiphysis (HP:0003370)1.84759278
145Periauricular skin pits (HP:0100277)1.83920148
146Preauricular pit (HP:0004467)1.83920148
147Spondylolisthesis (HP:0003302)1.83231056
148Coxa vara (HP:0002812)1.80331536
149Wrist flexion contracture (HP:0001239)1.79706251
150Broad alveolar ridges (HP:0000187)1.79663128
151Absent hand (HP:0004050)1.79177135
152Abnormality of the pulmonary veins (HP:0011718)1.78364868
153Decreased circulating renin level (HP:0003351)1.78272519
154Hyperactive renin-angiotensin system (HP:0000841)1.77454980
155Hydroureter (HP:0000072)1.77132384
156Malignant gastrointestinal tract tumors (HP:0006749)1.75865210
157Gastrointestinal carcinoma (HP:0002672)1.75865210
158Bladder neoplasm (HP:0009725)1.74690125
159Bladder carcinoma (HP:0002862)1.74690125
160Abnormality of midbrain morphology (HP:0002418)1.74320862
161Molar tooth sign on MRI (HP:0002419)1.74320862
162Abnormality of the clitoris (HP:0000056)1.74094839
163Abnormality of cochlea (HP:0000375)1.73921154
164Short thumb (HP:0009778)1.73739779
165Neoplasm of the oral cavity (HP:0100649)1.73090375
166Oligodactyly (hands) (HP:0001180)1.72660811
167Fair hair (HP:0002286)1.72222412
168Abnormality of the fingertips (HP:0001211)1.71833530
169Increased nuchal translucency (HP:0010880)1.70388584
170Abnormality of chromosome stability (HP:0003220)1.69710096
171Occipital encephalocele (HP:0002085)1.68899316
172Absent forearm bone (HP:0003953)1.67403640
173Aplasia involving forearm bones (HP:0009822)1.67403640
174Slender long bone (HP:0003100)1.65778687
175Generalized myoclonic seizures (HP:0002123)1.64970480
176Insidious onset (HP:0003587)1.64754808
177Termporal pattern (HP:0011008)1.64754808
178Facial hemangioma (HP:0000329)1.63949973

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR29.22301229
2MOS8.27743161
3TAOK35.56655412
4NEK63.27971178
5LATS13.19299441
6STK242.99666201
7LATS22.63851363
8MAP3K62.61609812
9TTK2.54345409
10CDK122.46178851
11MAP3K92.19382467
12MET1.97115790
13KSR21.96941413
14STK38L1.93836200
15CDC71.93733882
16PLK41.92266839
17STK101.88436759
18MAP3K131.77064676
19TRIM281.64215508
20BUB11.62649999
21ARAF1.62294478
22PRKCI1.60381803
23NTRK21.55768067
24TNIK1.41854013
25CDK81.35424035
26EIF2AK31.34061681
27CDK91.33570893
28DYRK21.33440154
29TAOK11.29112054
30PTK21.27242926
31BRSK11.20030803
32CDK191.19471034
33RAF11.03627067
34PIM11.02356091
35MELK1.01498766
36TNK20.98990833
37CSNK1G10.96659386
38RET0.95604036
39BRAF0.89529854
40NEK10.87426242
41PRKD30.86021313
42PLK10.84942318
43NLK0.83838643
44MAP3K80.82367924
45MAP3K40.82345657
46PAK60.81213088
47WNK10.81163531
48MARK30.75564654
49CSNK1G30.73572066
50PINK10.72989727
51CSNK1G20.71951619
52ZAK0.70413617
53NEK20.69481605
54NTRK30.67785435
55MST40.66943921
56STK30.62884335
57KSR10.62836302
58STK380.62782523
59CSNK1A1L0.62477647
60LRRK20.61505680
61NUAK10.61197022
62ERBB40.61004408
63BMPR1B0.60394641
64PKN20.58369401
65TIE10.58056709
66BRSK20.57361535
67MTOR0.56904344
68PRKG10.55930549
69TRIB30.55330860
70SRPK10.54306149
71TGFBR10.54243880
72HIPK20.50183420
73PKN10.48436555
74ABL20.47803657
75PRKCZ0.47162010
76TYRO30.45005693
77SGK2230.43252698
78SGK4940.43252698
79CHEK20.43237654
80ATR0.41149270
81PDK10.40350887
82SGK20.39079134
83AURKB0.38750019
84KIT0.38720039
85PRKD20.37727023
86AURKA0.37611690
87MAPK130.36898321
88STK390.35671875
89MAP2K70.34106971
90CDK50.34017346
91NEK90.33294473
92EPHA30.29695464
93PLK20.29353586
94PBK0.29293197
95CDK40.29273236
96MUSK0.29080790
97DMPK0.26808539
98AKT20.26442812
99EPHA40.24746412
100TLK10.24418490
101PRKAA10.23575978
102VRK10.23057605
103MAPK100.22325470
104EEF2K0.21967766
105PDPK10.21929274
106PRKACA0.21240601
107ROCK20.20894323
108EIF2AK10.20362185
109CAMK2A0.19465576
110MAPK110.19366163
111MAP2K40.17729677
112TRPM70.17386833
113MARK20.17030512
114SGK30.16854890
115CHUK0.16528798
116CSNK1D0.15852708
117CAMK1D0.15752610
118ROCK10.15181121
119CDK11A0.15152534
120CLK10.15045069
121ACVR1B0.13398453
122SGK10.13131372
123MAP3K10.13111145
124CDK10.11668137
125MAP2K10.11398110
126ABL10.10389539
127MAPKAPK30.10333806
128MAP3K70.09444935
129PAK10.06831462
130PRKAA20.06138367
131CDK20.05893378
132PLK30.05826998
133PNCK0.05005770
134ATM0.04998376
135CDK70.04173075
136MAPK10.03573050
137JAK20.02704631
138CSNK1A10.02654628
139ERN10.02540493
140ADRBK10.01860489
141PRKACB0.01823957
142RPS6KA30.00525377
143CSNK1E0.00376158
144CHEK10.00191839
145TESK2-0.0143234
146EPHB1-0.0068238
147MAP3K5-0.0054153
148GSK3B-0.0038408

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049135.78113666
2Oocyte meiosis_Homo sapiens_hsa041144.34238062
3Mismatch repair_Homo sapiens_hsa034303.95515396
4Cell cycle_Homo sapiens_hsa041103.79183393
5RNA degradation_Homo sapiens_hsa030183.60799130
6Circadian rhythm_Homo sapiens_hsa047103.38993698
7Basal transcription factors_Homo sapiens_hsa030223.16175914
8Progesterone-mediated oocyte maturation_Homo sapiens_hsa049143.15857648
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.10801148
10Folate biosynthesis_Homo sapiens_hsa007902.56865101
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.10193751
12Linoleic acid metabolism_Homo sapiens_hsa005912.06278143
13Cysteine and methionine metabolism_Homo sapiens_hsa002702.05421150
14Pancreatic cancer_Homo sapiens_hsa052122.00359759
15Ether lipid metabolism_Homo sapiens_hsa005651.99372209
16Base excision repair_Homo sapiens_hsa034101.79159109
17Dorso-ventral axis formation_Homo sapiens_hsa043201.76544679
18Non-homologous end-joining_Homo sapiens_hsa034501.57545900
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.56951920
20GnRH signaling pathway_Homo sapiens_hsa049121.54809636
21MicroRNAs in cancer_Homo sapiens_hsa052061.50986199
22TGF-beta signaling pathway_Homo sapiens_hsa043501.50262232
23Phototransduction_Homo sapiens_hsa047441.44082314
24DNA replication_Homo sapiens_hsa030301.44055466
25mRNA surveillance pathway_Homo sapiens_hsa030151.39500516
26Notch signaling pathway_Homo sapiens_hsa043301.21575067
27Long-term depression_Homo sapiens_hsa047301.20600892
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10830287
29ABC transporters_Homo sapiens_hsa020101.07221310
30p53 signaling pathway_Homo sapiens_hsa041151.06001499
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04159207
32RNA transport_Homo sapiens_hsa030130.99098030
33Taste transduction_Homo sapiens_hsa047420.98491518
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97320567
35Colorectal cancer_Homo sapiens_hsa052100.97243377
36Inositol phosphate metabolism_Homo sapiens_hsa005620.96091790
37Choline metabolism in cancer_Homo sapiens_hsa052310.96027656
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95237514
39Fanconi anemia pathway_Homo sapiens_hsa034600.94349370
40Fatty acid elongation_Homo sapiens_hsa000620.91745328
41Prolactin signaling pathway_Homo sapiens_hsa049170.88732427
42Nicotine addiction_Homo sapiens_hsa050330.88425919
43Morphine addiction_Homo sapiens_hsa050320.88315405
44Adherens junction_Homo sapiens_hsa045200.87698424
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87007235
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85209318
47VEGF signaling pathway_Homo sapiens_hsa043700.83363651
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80671221
49Glutamatergic synapse_Homo sapiens_hsa047240.76995475
50Complement and coagulation cascades_Homo sapiens_hsa046100.76905969
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76779715
52Vitamin B6 metabolism_Homo sapiens_hsa007500.76091317
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75603298
54GABAergic synapse_Homo sapiens_hsa047270.75572236
55MAPK signaling pathway_Homo sapiens_hsa040100.73997593
56Hippo signaling pathway_Homo sapiens_hsa043900.73917834
57Thyroid cancer_Homo sapiens_hsa052160.69700702
58Homologous recombination_Homo sapiens_hsa034400.69391727
59RNA polymerase_Homo sapiens_hsa030200.68311340
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.68131492
61Nucleotide excision repair_Homo sapiens_hsa034200.67934708
62FoxO signaling pathway_Homo sapiens_hsa040680.67861734
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67773059
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65154141
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64349256
66Purine metabolism_Homo sapiens_hsa002300.63878123
67Viral carcinogenesis_Homo sapiens_hsa052030.63571697
68Ras signaling pathway_Homo sapiens_hsa040140.62138372
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.58576445
70HTLV-I infection_Homo sapiens_hsa051660.58125513
71Estrogen signaling pathway_Homo sapiens_hsa049150.58067833
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.57288141
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56693485
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.51211553
75Herpes simplex infection_Homo sapiens_hsa051680.50899625
76Olfactory transduction_Homo sapiens_hsa047400.49374297
77Wnt signaling pathway_Homo sapiens_hsa043100.47811836
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46471782
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45865607
80Gap junction_Homo sapiens_hsa045400.44450127
81Chronic myeloid leukemia_Homo sapiens_hsa052200.44008888
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43369855
83Glucagon signaling pathway_Homo sapiens_hsa049220.42785728
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42561786
85Endometrial cancer_Homo sapiens_hsa052130.42540444
86Tight junction_Homo sapiens_hsa045300.41210226
87Bladder cancer_Homo sapiens_hsa052190.40622911
88Renal cell carcinoma_Homo sapiens_hsa052110.39897804
89Synaptic vesicle cycle_Homo sapiens_hsa047210.39812497
90Propanoate metabolism_Homo sapiens_hsa006400.39307270
91Serotonergic synapse_Homo sapiens_hsa047260.38946950
92mTOR signaling pathway_Homo sapiens_hsa041500.37735620
93Oxytocin signaling pathway_Homo sapiens_hsa049210.37141145
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35417086
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34962116
96Long-term potentiation_Homo sapiens_hsa047200.34544642
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.34093239
98Regulation of autophagy_Homo sapiens_hsa041400.33182325
99Bile secretion_Homo sapiens_hsa049760.32276699
100Cholinergic synapse_Homo sapiens_hsa047250.32175252
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31556583
102Spliceosome_Homo sapiens_hsa030400.29746207
103Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.28573096
104Arginine and proline metabolism_Homo sapiens_hsa003300.28004024
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.26138473
106Influenza A_Homo sapiens_hsa051640.25441813
107cAMP signaling pathway_Homo sapiens_hsa040240.24733589
108Small cell lung cancer_Homo sapiens_hsa052220.24484856
109Arginine biosynthesis_Homo sapiens_hsa002200.24443927
110Protein digestion and absorption_Homo sapiens_hsa049740.24315474
111Gastric acid secretion_Homo sapiens_hsa049710.23864390
112Glioma_Homo sapiens_hsa052140.21941910
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.21761180
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21046386
115Pyruvate metabolism_Homo sapiens_hsa006200.20485104
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20090043
117Hedgehog signaling pathway_Homo sapiens_hsa043400.19202201
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.18931692
119ErbB signaling pathway_Homo sapiens_hsa040120.18728935
120Insulin resistance_Homo sapiens_hsa049310.18229476
121Caffeine metabolism_Homo sapiens_hsa002320.17631206
122Histidine metabolism_Homo sapiens_hsa003400.17551419
123Huntingtons disease_Homo sapiens_hsa050160.17310789
124Glutathione metabolism_Homo sapiens_hsa004800.16946686
125Pyrimidine metabolism_Homo sapiens_hsa002400.16911408
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16406619
127Non-small cell lung cancer_Homo sapiens_hsa052230.15905169
128Hepatitis B_Homo sapiens_hsa051610.15003091
129Insulin secretion_Homo sapiens_hsa049110.13558991
130Amoebiasis_Homo sapiens_hsa051460.11818295
131Vitamin digestion and absorption_Homo sapiens_hsa049770.11743404
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.10217500
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.09852625
134Circadian entrainment_Homo sapiens_hsa047130.09677954
135Prostate cancer_Homo sapiens_hsa052150.09550436
136Phagosome_Homo sapiens_hsa041450.07652061
137PI3K-Akt signaling pathway_Homo sapiens_hsa041510.06881737
138HIF-1 signaling pathway_Homo sapiens_hsa040660.05275696
139Calcium signaling pathway_Homo sapiens_hsa040200.05248632

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