H2AFB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the most centromeric copy which is in intron 22 of the F8 gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.84478123
2reproduction (GO:0000003)9.76113838
3axonemal dynein complex assembly (GO:0070286)9.39411398
4motile cilium assembly (GO:0044458)9.35160132
5cilium movement (GO:0003341)8.00604346
6cilium or flagellum-dependent cell motility (GO:0001539)7.82376759
7regulation of cilium movement (GO:0003352)7.79743748
8single fertilization (GO:0007338)7.26067814
9sperm capacitation (GO:0048240)7.24804711
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.15291438
11negative regulation of inclusion body assembly (GO:0090084)7.08823944
12synaptonemal complex organization (GO:0070193)6.90548019
13spermatid nucleus differentiation (GO:0007289)6.89732795
14synaptonemal complex assembly (GO:0007130)6.89409207
15organic cation transport (GO:0015695)6.70699882
16spermatogenesis (GO:0007283)6.68922098
17male gamete generation (GO:0048232)6.66415973
18male meiosis (GO:0007140)6.50904631
19microtubule depolymerization (GO:0007019)6.33743650
20sexual reproduction (GO:0019953)6.32433396
21gamete generation (GO:0007276)6.12544576
22fertilization (GO:0009566)6.11361275
23regulation of inclusion body assembly (GO:0090083)6.02719047
24piRNA metabolic process (GO:0034587)5.86148783
25calcium ion-dependent exocytosis (GO:0017156)5.81096099
26single strand break repair (GO:0000012)5.61523790
27chromosome condensation (GO:0030261)5.52518216
28germ cell development (GO:0007281)5.40880884
29cellular process involved in reproduction in multicellular organism (GO:0022412)5.32872839
30glycerol ether metabolic process (GO:0006662)5.25003305
31DNA packaging (GO:0006323)5.21043084
32cell recognition (GO:0008037)5.10782113
33ventricular system development (GO:0021591)4.85666851
34ether metabolic process (GO:0018904)4.85326865
35multicellular organismal reproductive process (GO:0048609)4.81071078
36microtubule severing (GO:0051013)4.67857750
37chromosome organization involved in meiosis (GO:0070192)4.59460453
38regulation of microtubule-based movement (GO:0060632)4.58013930
39seminiferous tubule development (GO:0072520)4.33182977
40sequestering of actin monomers (GO:0042989)4.26643681
41protein K11-linked deubiquitination (GO:0035871)4.23508355
42male meiosis I (GO:0007141)4.13379957
43chaperone-mediated protein complex assembly (GO:0051131)3.95101234
44meiotic nuclear division (GO:0007126)3.94466085
45left/right pattern formation (GO:0060972)3.94167658
46DNA methylation involved in gamete generation (GO:0043046)3.86704626
47multicellular organismal development (GO:0007275)3.85994759
48genitalia morphogenesis (GO:0035112)3.52765181
49monoubiquitinated protein deubiquitination (GO:0035520)3.40950059
50positive regulation of macrophage activation (GO:0043032)3.39759802
51nucleus organization (GO:0006997)3.30742459
52microtubule polymerization or depolymerization (GO:0031109)3.30450252
53protein refolding (GO:0042026)3.29570393
54meiosis I (GO:0007127)3.26884374
55chromatin silencing (GO:0006342)3.25256102
56glycolytic process (GO:0006096)3.21447623
57protein polyglutamylation (GO:0018095)3.16403403
58polyamine biosynthetic process (GO:0006596)3.12598850
59regulation of spindle checkpoint (GO:0090231)3.03630662
60interferon-gamma secretion (GO:0072643)3.00892855
61amino-acid betaine transport (GO:0015838)2.99256410
62carnitine transport (GO:0015879)2.99256410
63protein-DNA complex disassembly (GO:0032986)2.98455959
64nucleosome disassembly (GO:0006337)2.98455959
65meiotic cell cycle (GO:0051321)2.95515677
66nucleoside diphosphate phosphorylation (GO:0006165)2.88108326
67polyol catabolic process (GO:0046174)2.87849227
68alditol metabolic process (GO:0019400)2.83148860
69carnitine transmembrane transport (GO:1902603)2.80643151
70RNA localization (GO:0006403)2.76788291
71mitotic sister chromatid cohesion (GO:0007064)2.73302384
72cilium organization (GO:0044782)2.72000074
73protein localization to cilium (GO:0061512)2.67224475
74RNA destabilization (GO:0050779)2.67217907
75GTP biosynthetic process (GO:0006183)2.65749654
76centriole assembly (GO:0098534)2.63217930
77cilium assembly (GO:0042384)2.61885401
78cellular component assembly involved in morphogenesis (GO:0010927)2.59655936
79microtubule-based movement (GO:0007018)2.56703111
80regulation of cilium assembly (GO:1902017)2.55266010
81meiotic cell cycle process (GO:1903046)2.55231825
82negative regulation of gene expression, epigenetic (GO:0045814)2.47425780
83lactate metabolic process (GO:0006089)2.45358458
84cellular response to arsenic-containing substance (GO:0071243)2.44849824
85synapsis (GO:0007129)2.44216547
86cilium morphogenesis (GO:0060271)2.43869810
87glycerol metabolic process (GO:0006071)2.41313001
88axoneme assembly (GO:0035082)2.38691981
89cell wall macromolecule metabolic process (GO:0044036)15.7185978
90cell wall macromolecule catabolic process (GO:0016998)15.7185978
91sperm motility (GO:0030317)14.2187503
92fusion of sperm to egg plasma membrane (GO:0007342)13.2519790
93acrosome reaction (GO:0007340)12.2650670
94sperm-egg recognition (GO:0035036)11.7113660
95acrosome assembly (GO:0001675)11.5627297
96binding of sperm to zona pellucida (GO:0007339)10.7481491
97multicellular organism reproduction (GO:0032504)10.7430825
98cell-cell recognition (GO:0009988)10.5068728
99epithelial cilium movement (GO:0003351)10.1627422
100plasma membrane fusion (GO:0045026)10.1129634

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.18978028
2EZH2_22144423_ChIP-Seq_EOC_Human3.56617386
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.54253666
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.47116182
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.96112218
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.86652285
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.83480437
8VDR_22108803_ChIP-Seq_LS180_Human2.35781216
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.29187166
10CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.23987504
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.20408211
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.18652907
13EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07964449
14KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.96194323
15ZNF274_21170338_ChIP-Seq_K562_Hela1.90973978
16PCGF2_27294783_Chip-Seq_ESCs_Mouse1.83143535
17TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.77310825
18STAT1_17558387_ChIP-Seq_HELA_Human1.74778699
19MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.74154120
20ELK4_26923725_Chip-Seq_MESODERM_Mouse1.70964318
21SOX2_22085726_ChIP-Seq_NPCs_Mouse1.69201885
22RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.69117240
23FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66652302
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.64471925
25KDM2B_26808549_Chip-Seq_REH_Human1.63944655
26GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.62965548
27TAL1_26923725_Chip-Seq_HPCs_Mouse1.57266645
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56121268
29* GATA3_21867929_ChIP-Seq_CD8_Mouse1.55803130
30* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.52000686
31WDR5_24793694_ChIP-Seq_LNCAP_Human1.51405269
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.49361898
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42040410
34CBP_20019798_ChIP-Seq_JUKART_Human1.42040410
35PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.38606135
36REST_21632747_ChIP-Seq_MESCs_Mouse1.37473070
37P53_21459846_ChIP-Seq_SAOS-2_Human1.37016380
38FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.36954189
39LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.36190248
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34378351
41TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33881387
42GATA3_21867929_ChIP-Seq_TH1_Mouse1.33240229
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33155195
44* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31595896
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30721004
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.29802857
47* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29043819
48FLI1_21867929_ChIP-Seq_TH2_Mouse1.27824010
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27329341
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21568347
51GF1_26923725_Chip-Seq_HPCs_Mouse1.20423317
52CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19696092
53RAD21_21589869_ChIP-Seq_MESCs_Mouse1.19653842
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19550971
55PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16780887
56CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16013722
57CRX_20693478_ChIP-Seq_RETINA_Mouse1.15494832
58SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14637554
59NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14623153
60SPI1_26923725_Chip-Seq_HPCs_Mouse1.13673718
61KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.13359403
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11457872
63* NANOG_18555785_Chip-Seq_ESCs_Mouse1.09727595
64EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.08302275
65GATA1_19941827_ChIP-Seq_MEL86_Mouse1.07956067
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07783648
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07450687
68SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.07285604
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07282420
70RUNX1_26923725_Chip-Seq_HPCs_Mouse1.07266059
71ERG_20517297_ChIP-Seq_VCAP_Human1.05007625
72* ESET_19884257_ChIP-Seq_ESCs_Mouse1.03714066
73* CMYC_18555785_Chip-Seq_ESCs_Mouse1.02152172
74YY1_22570637_ChIP-Seq_MALME-3M_Human1.01398838
75RARA_24833708_ChIP-Seq_LIVER_Mouse1.01113690
76TAF15_26573619_Chip-Seq_HEK293_Human1.00871234
77SOX9_26525672_Chip-Seq_HEART_Mouse1.00781951
78* P53_22387025_ChIP-Seq_ESCs_Mouse1.00711211
79* OCT4_18555785_Chip-Seq_ESCs_Mouse1.00173492
80TET1_21451524_ChIP-Seq_MESCs_Mouse1.00073202
81* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99848862
82RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99747668
83LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99231334
84JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.99082710
85MYC_27129775_Chip-Seq_CORNEA_Mouse0.98389308
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97139535
87* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95951864
88PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95473101
89FLI1_21867929_ChIP-Seq_CD8_Mouse0.95150458
90OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93382075
91ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92907204
92* P300_18555785_Chip-Seq_ESCs_Mouse0.92437336
93NFYB_21822215_ChIP-Seq_K562_Human0.92245229
94* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90523396
95* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90523396
96GF1B_26923725_Chip-Seq_HPCs_Mouse0.89280952
97* KLF4_18555785_Chip-Seq_ESCs_Mouse0.88684466
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88386832
99NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.87334099
100EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.87165773

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.14224662
2MP0001929_abnormal_gametogenesis5.59751833
3MP0008877_abnormal_DNA_methylation3.59312366
4MP0002161_abnormal_fertility/fecundity3.34226591
5MP0002210_abnormal_sex_determination3.30464462
6MP0005670_abnormal_white_adipose2.96691078
7MP0001145_abnormal_male_reproductive2.82858470
8MP0000653_abnormal_sex_gland2.44743087
9MP0005410_abnormal_fertilization16.8152415
10MP0002653_abnormal_ependyma_morphology1.89371817
11MP0004233_abnormal_muscle_weight1.66948882
12MP0002160_abnormal_reproductive_system1.55107864
13MP0003646_muscle_fatigue1.43402626
14MP0001765_abnormal_ion_homeostasis1.18168090
15MP0005623_abnormal_meninges_morphology1.12464948
16MP0002282_abnormal_trachea_morphology1.04944420
17MP0001984_abnormal_olfaction0.97623433
18MP0002234_abnormal_pharynx_morphology0.97551218
19MP0008058_abnormal_DNA_repair0.86780944
20MP0005647_abnormal_sex_gland0.81532062
21MP0005389_reproductive_system_phenotype0.74555612
22MP0005636_abnormal_mineral_homeostasis0.69182715
23MP0009046_muscle_twitch0.69004671
24MP0003115_abnormal_respiratory_system0.65634679
25MP0003011_delayed_dark_adaptation0.60354218
26MP0005666_abnormal_adipose_tissue0.55499429
27MP0002736_abnormal_nociception_after0.55337645
28MP0006036_abnormal_mitochondrial_physio0.54981047
29MP0004036_abnormal_muscle_relaxation0.54502694
30MP0003329_amyloid_beta_deposits0.54166036
31MP0001324_abnormal_eye_pigmentation0.53331990
32MP0002269_muscular_atrophy0.51636398
33MP0001764_abnormal_homeostasis0.50237222
34MP0000358_abnormal_cell_content/0.48766772
35MP0003878_abnormal_ear_physiology0.47313111
36MP0005377_hearing/vestibular/ear_phenot0.47313111
37MP0008995_early_reproductive_senescence0.46996044
38MP0002102_abnormal_ear_morphology0.46846366
39MP0005551_abnormal_eye_electrophysiolog0.45131754
40MP0003699_abnormal_female_reproductive0.43366917
41MP0001293_anophthalmia0.42734683
42MP0002139_abnormal_hepatobiliary_system0.40860262
43MP0002928_abnormal_bile_duct0.40418531
44MP0005253_abnormal_eye_physiology0.38767911
45MP0004133_heterotaxia0.38594582
46MP0009115_abnormal_fat_cell0.37818882
47MP0006035_abnormal_mitochondrial_morpho0.35899304
48MP0004019_abnormal_vitamin_homeostasis0.35033749
49MP0003950_abnormal_plasma_membrane0.34978724
50MP0010094_abnormal_chromosome_stability0.34954362
51MP0000534_abnormal_ureter_morphology0.34926843
52MP0003633_abnormal_nervous_system0.34129745
53MP0002971_abnormal_brown_adipose0.34072460
54MP0001968_abnormal_touch/_nociception0.34000621
55MP0004811_abnormal_neuron_physiology0.31529845
56MP0000604_amyloidosis0.30170763
57MP0005397_hematopoietic_system_phenotyp0.29429243
58MP0001545_abnormal_hematopoietic_system0.29429243
59MP0005391_vision/eye_phenotype0.27935485
60MP0001849_ear_inflammation0.27630094
61MP0004145_abnormal_muscle_electrophysio0.26473366
62MP0002132_abnormal_respiratory_system0.25685026
63MP0009278_abnormal_bone_marrow0.25121301
64MP0003631_nervous_system_phenotype0.25007354
65MP0001119_abnormal_female_reproductive0.24599545
66MP0002169_no_abnormal_phenotype0.24204446
67MP0002873_normal_phenotype0.23973312
68MP0003942_abnormal_urinary_system0.23787163
69MP0005319_abnormal_enzyme/_coenzyme0.22668857
70MP0008569_lethality_at_weaning0.22553299
71MP0003111_abnormal_nucleus_morphology0.21728037
72MP0003861_abnormal_nervous_system0.21329133
73MP0002152_abnormal_brain_morphology0.21287212
74MP0000569_abnormal_digit_pigmentation0.21180681
75MP0002693_abnormal_pancreas_physiology0.21152642
76MP0008875_abnormal_xenobiotic_pharmacok0.20640915
77MP0003948_abnormal_gas_homeostasis0.20546421
78MP0004742_abnormal_vestibular_system0.19975365
79MP0005365_abnormal_bile_salt0.19646133
80MP0004270_analgesia0.19633248
81MP0003879_abnormal_hair_cell0.18685708
82MP0001730_embryonic_growth_arrest0.18161252
83MP0002229_neurodegeneration0.17356792
84MP0003959_abnormal_lean_body0.16984052
85MP0001348_abnormal_lacrimal_gland0.16460147
86MP0002118_abnormal_lipid_homeostasis0.15896130
87MP0004043_abnormal_pH_regulation0.15676104
88MP0002909_abnormal_adrenal_gland0.14615949
89MP0010307_abnormal_tumor_latency0.14270043
90MP0000001_mammalian_phenotype0.13981365
91MP0000751_myopathy0.13957053
92MP0005195_abnormal_posterior_eye0.13893016
93MP0002295_abnormal_pulmonary_circulatio0.13609764
94MP0000313_abnormal_cell_death0.13108436
95MP0002092_abnormal_eye_morphology0.12900517
96MP0001661_extended_life_span0.12553347
97MP0002084_abnormal_developmental_patter0.12109567
98MP0000462_abnormal_digestive_system0.12033783
99MP0005375_adipose_tissue_phenotype0.11953720
100MP0000920_abnormal_myelination0.11611304

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.46004654
2Abnormal respiratory motile cilium morphology (HP:0005938)9.46004654
3Abnormal respiratory motile cilium physiology (HP:0012261)9.27666825
4Chronic bronchitis (HP:0004469)7.52316358
5Rhinitis (HP:0012384)7.39463781
6Abnormal ciliary motility (HP:0012262)7.35579147
7Infertility (HP:0000789)6.80540346
8Nasal polyposis (HP:0100582)6.38192444
9Abnormality of the nasal mucosa (HP:0000433)5.25395621
10Male infertility (HP:0003251)4.61191905
11Bronchitis (HP:0012387)4.48072291
12Bronchiectasis (HP:0002110)4.35279329
13Nephronophthisis (HP:0000090)4.03731364
14Abnormal spermatogenesis (HP:0008669)3.49560341
15Recurrent sinusitis (HP:0011108)3.32156676
16Recurrent otitis media (HP:0000403)3.22279445
17Abnormality of the renal medulla (HP:0100957)3.03404365
18Tubulointerstitial nephritis (HP:0001970)2.91605962
19Medial flaring of the eyebrow (HP:0010747)2.67724183
20Abnormality of midbrain morphology (HP:0002418)2.58498765
21Molar tooth sign on MRI (HP:0002419)2.58498765
22Tubular atrophy (HP:0000092)2.57153736
23Recurrent bronchitis (HP:0002837)2.45242912
24Abnormal gallbladder physiology (HP:0012438)2.43856550
25Cholecystitis (HP:0001082)2.43856550
26Tubulointerstitial abnormality (HP:0001969)2.35287680
27Impulsivity (HP:0100710)2.33379922
28Azoospermia (HP:0000027)2.25953539
29Dyschromatopsia (HP:0007641)2.13480778
30Absent/shortened dynein arms (HP:0200106)13.6171989
31Dynein arm defect of respiratory motile cilia (HP:0012255)13.6171989
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.8778038
33Asymmetric septal hypertrophy (HP:0001670)1.96974415
34Gonadotropin excess (HP:0000837)1.94839061
35Double outlet right ventricle (HP:0001719)1.90056889
36Congenital malformation of the right heart (HP:0011723)1.90056889
37Decreased central vision (HP:0007663)1.89780616
38Choroideremia (HP:0001139)1.87052981
39Tubulointerstitial fibrosis (HP:0005576)1.78872760
40Stage 5 chronic kidney disease (HP:0003774)1.74507452
41Spastic tetraparesis (HP:0001285)1.72349360
42Postaxial foot polydactyly (HP:0001830)1.68489942
43Abnormality of renal excretion (HP:0011036)1.68247543
44Abnormal drinking behavior (HP:0030082)1.65524902
45Polydipsia (HP:0001959)1.65524902
46Bundle branch block (HP:0011710)1.65419945
47Heterotopia (HP:0002282)1.63351781
48Aplasia/Hypoplasia of the lens (HP:0008063)1.62549131
49Hemorrhage of the eye (HP:0011885)1.61911428
50Abnormality of the renal cortex (HP:0011035)1.58153093
51Gait imbalance (HP:0002141)1.57562648
52Congenital hepatic fibrosis (HP:0002612)1.57392841
53Abnormal biliary tract physiology (HP:0012439)1.57243377
54Bile duct proliferation (HP:0001408)1.57243377
55Congenital primary aphakia (HP:0007707)1.57034947
56Abnormality of permanent molar morphology (HP:0011071)1.53909585
57Abnormality of the dental root (HP:0006486)1.53909585
58Taurodontia (HP:0000679)1.53909585
59Constricted visual fields (HP:0001133)1.51024784
60Chronic sinusitis (HP:0011109)1.50290518
61Neurofibrillary tangles (HP:0002185)1.48260431
62Fatigable weakness (HP:0003473)1.48070821
63Abnormality of the neuromuscular junction (HP:0003398)1.48070821
64Bell-shaped thorax (HP:0001591)1.47430974
65Decreased electroretinogram (ERG) amplitude (HP:0000654)1.46875254
66Oculomotor apraxia (HP:0000657)1.46786196
67Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.45404817
68Sensory axonal neuropathy (HP:0003390)1.44696272
69Abnormality of the dental pulp (HP:0006479)1.43201353
70Abnormality of molar (HP:0011077)1.41825407
71Abnormality of molar morphology (HP:0011070)1.41825407
72Postaxial hand polydactyly (HP:0001162)1.41652203
73Easy fatigability (HP:0003388)1.41569605
74Hypoplasia of the capital femoral epiphysis (HP:0003090)1.40753722
75Optic nerve hypoplasia (HP:0000609)1.37706988
76Short ribs (HP:0000773)1.36378347
77Abnormality of saccadic eye movements (HP:0000570)1.35184971
78Nephrogenic diabetes insipidus (HP:0009806)1.32422906
79Cystic liver disease (HP:0006706)1.31565017
80Abnormal urine output (HP:0012590)1.31281764
81Cerebellar dysplasia (HP:0007033)1.30280961
82Exercise-induced myalgia (HP:0003738)1.28795479
83Renal dysplasia (HP:0000110)1.26864502
84Abnormality of dentin (HP:0010299)1.26588472
85Vascular calcification (HP:0004934)1.25530482
86Myoglobinuria (HP:0002913)1.24882986
87Loss of speech (HP:0002371)1.24749707
88Type 2 muscle fiber atrophy (HP:0003554)1.24560206
89Vaginal atresia (HP:0000148)1.24341848
90Abnormality of ocular smooth pursuit (HP:0000617)1.22136193
91Cerebral inclusion bodies (HP:0100314)1.21777195
92Hypercholesterolemia (HP:0003124)1.21673791
93Pancreatic fibrosis (HP:0100732)1.20147398
94Genital tract atresia (HP:0001827)1.20060236
95Impaired smooth pursuit (HP:0007772)1.19245435
96Facial cleft (HP:0002006)1.18008187
97Generalized muscle weakness (HP:0003324)1.16255082
98Poor coordination (HP:0002370)1.16160728
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.15974694
100Rhabdomyolysis (HP:0003201)1.13778218

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.00943180
2PDK39.00943180
3PDK25.85842356
4TESK15.78975641
5PRKD34.13131298
6ICK3.96733033
7PTK2B1.89448441
8WNK41.70120742
9STK391.67000058
10STK381.65612758
11DYRK1B1.39440290
12NEK21.36718196
13PNCK1.31962465
14PDK11.27025806
15IRAK11.02783081
16DYRK30.78420649
17LMTK20.75997650
18PDPK10.75185636
19RIPK40.72163823
20TYRO30.67103528
21IRAK20.63264860
22MAPK150.61066626
23EEF2K0.60105832
24MAP2K60.59332089
25PASK0.59327233
26WNK10.57396416
27CCNB10.56434868
28CHEK20.52712268
29MUSK0.47767080
30PINK10.46848776
31STK30.46252943
32TTK0.45710835
33TESK20.43049447
34PLK40.36734931
35NTRK20.36530418
36STK38L0.34188235
37PAK10.33567294
38PRKCG0.32931820
39CAMK1G0.32241309
40MAP3K100.30929506
41CHEK10.30296811
42PAK20.23601359
43MAPKAPK50.22015149
44MARK20.21775599
45CAMKK10.20216075
46PRKCZ0.20199589
47ATM0.19568796
48MTOR0.18061568
49PRKG20.15249123
50PRKAA10.15125153
51PAK40.15037197
52BRSK20.14975068
53CDK150.13414656
54PRKCQ0.13233299
55NEK60.13177009
56ATR0.12484634
57PKN10.12014185
58RPS6KB10.11587265
59CDK180.10965698
60WEE10.09516809
61CDK11A0.09430637
62MARK30.08160578
63PLK10.07911037
64YES10.07298675
65CDK140.07263122
66RPS6KA10.06359868
67BRSK10.06058476
68CSNK2A10.05627721
69BRAF0.04998692
70PRKACG0.04808017
71GSK3B0.04767869
72CAMK2A0.04469786
73PRKG10.04457116
74CSF1R0.04002497
75PRKCD0.03185429
76MAP3K50.02506167
77PIM10.02397243
78CDC70.02105952
79CDK60.01894952
80PRKCB0.01720756
81CSNK2A20.01475386
82PRKCA0.01120142
83MAPK80.00965516
84CDK20.00624923
85STK110.00509901
86STK100.00240390
87PDGFRB-0.0435111
88AURKA-0.0335176
89CDK12-0.0326934
90RIPK1-0.0291677
91PRKACA-0.0267083
92CLK1-0.0256721
93TRIB3-0.0233659
94PRKACB-0.0147292
95WNK3-0.0134533
96RPS6KA3-0.0117527
97EGFR-0.0115821
98GSK3A-0.0106453
99CDK1-0.0068900
100CSNK1D-0.0038499

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.53653966
2Fatty acid biosynthesis_Homo sapiens_hsa000614.40869452
3Pyruvate metabolism_Homo sapiens_hsa006203.41630890
4Vitamin B6 metabolism_Homo sapiens_hsa007503.28809147
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.08874599
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.07408777
7Linoleic acid metabolism_Homo sapiens_hsa005913.01607966
8Glucagon signaling pathway_Homo sapiens_hsa049222.52962696
9Propanoate metabolism_Homo sapiens_hsa006402.49678866
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.44137934
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.12211818
12Basal transcription factors_Homo sapiens_hsa030222.04783521
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.01559539
14Selenocompound metabolism_Homo sapiens_hsa004501.98063198
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.96267300
16Glycerolipid metabolism_Homo sapiens_hsa005611.94105675
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.93020157
18PPAR signaling pathway_Homo sapiens_hsa033201.78845163
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.75246219
20Oocyte meiosis_Homo sapiens_hsa041141.71575397
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.71406347
22Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.68780306
23Mineral absorption_Homo sapiens_hsa049781.64676061
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.59078466
25Fat digestion and absorption_Homo sapiens_hsa049751.52140220
26Fructose and mannose metabolism_Homo sapiens_hsa000511.49336262
27Cardiac muscle contraction_Homo sapiens_hsa042601.46168303
28Ether lipid metabolism_Homo sapiens_hsa005651.45237552
29Amphetamine addiction_Homo sapiens_hsa050311.45025151
30Carbon metabolism_Homo sapiens_hsa012001.43963261
31Pentose phosphate pathway_Homo sapiens_hsa000301.41218728
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36192163
33Fatty acid degradation_Homo sapiens_hsa000711.33356923
34Fatty acid metabolism_Homo sapiens_hsa012121.29772423
35Glutathione metabolism_Homo sapiens_hsa004801.23686470
36Collecting duct acid secretion_Homo sapiens_hsa049661.13971396
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12000403
38Dorso-ventral axis formation_Homo sapiens_hsa043201.11978809
39Antigen processing and presentation_Homo sapiens_hsa046121.04874552
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03896047
41Renin secretion_Homo sapiens_hsa049241.02843475
42Purine metabolism_Homo sapiens_hsa002301.01837911
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.98144182
44Fanconi anemia pathway_Homo sapiens_hsa034600.93267058
45Bile secretion_Homo sapiens_hsa049760.92705149
46Insulin secretion_Homo sapiens_hsa049110.90702493
47Huntingtons disease_Homo sapiens_hsa050160.90567517
48Chemical carcinogenesis_Homo sapiens_hsa052040.89211602
49Hedgehog signaling pathway_Homo sapiens_hsa043400.87450784
50Thyroid hormone synthesis_Homo sapiens_hsa049180.82315507
51Biosynthesis of amino acids_Homo sapiens_hsa012300.82281792
52Arachidonic acid metabolism_Homo sapiens_hsa005900.77698234
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.75569500
54mRNA surveillance pathway_Homo sapiens_hsa030150.75244560
55Estrogen signaling pathway_Homo sapiens_hsa049150.71453997
56Long-term potentiation_Homo sapiens_hsa047200.68457510
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.67795173
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66387491
59Inositol phosphate metabolism_Homo sapiens_hsa005620.65957106
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65414046
61Pancreatic secretion_Homo sapiens_hsa049720.63999636
62Synaptic vesicle cycle_Homo sapiens_hsa047210.62970535
63Salivary secretion_Homo sapiens_hsa049700.62449156
64Legionellosis_Homo sapiens_hsa051340.59724866
65Protein digestion and absorption_Homo sapiens_hsa049740.57808372
66Sulfur metabolism_Homo sapiens_hsa009200.57303721
67Calcium signaling pathway_Homo sapiens_hsa040200.57060569
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56102142
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55378638
70Gastric acid secretion_Homo sapiens_hsa049710.55343720
71RNA transport_Homo sapiens_hsa030130.53783643
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53388077
73Renin-angiotensin system_Homo sapiens_hsa046140.51707402
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51067674
75ABC transporters_Homo sapiens_hsa020100.45821114
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45496979
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43313952
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43136111
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.42613991
80Metabolic pathways_Homo sapiens_hsa011000.42599700
81Endocytosis_Homo sapiens_hsa041440.42367491
82AMPK signaling pathway_Homo sapiens_hsa041520.40329783
83Circadian entrainment_Homo sapiens_hsa047130.39201873
84cAMP signaling pathway_Homo sapiens_hsa040240.36559881
85Taste transduction_Homo sapiens_hsa047420.33969312
86VEGF signaling pathway_Homo sapiens_hsa043700.28401204
87Pyrimidine metabolism_Homo sapiens_hsa002400.25250769
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23845163
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21996626
90Cocaine addiction_Homo sapiens_hsa050300.18646417
91HIF-1 signaling pathway_Homo sapiens_hsa040660.15843652
92Salmonella infection_Homo sapiens_hsa051320.10392540
93Wnt signaling pathway_Homo sapiens_hsa043100.08275252
94B cell receptor signaling pathway_Homo sapiens_hsa046620.05886648
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.05741153
96* Systemic lupus erythematosus_Homo sapiens_hsa053220.05339302
97Glutamatergic synapse_Homo sapiens_hsa047240.04878956
98Basal cell carcinoma_Homo sapiens_hsa052170.03533443
99Insulin resistance_Homo sapiens_hsa049310.02850476
100N-Glycan biosynthesis_Homo sapiens_hsa005100.02718413

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