H2AFJ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is located on chromosome 12 and encodes a replication-independent histone that is a variant H2A histone. The protein is divergent at the C-terminus compared to the consensus H2A histone family member. This gene also encodes an antimicrobial peptide with antibacterial and antifungal activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)8.52598315
2viral transcription (GO:0019083)8.52398281
3translational termination (GO:0006415)8.13982813
4ribosomal small subunit biogenesis (GO:0042274)7.90648028
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.22143649
6protein targeting to ER (GO:0045047)7.09307191
7cotranslational protein targeting to membrane (GO:0006613)7.08342717
8translational elongation (GO:0006414)6.92731233
9establishment of protein localization to endoplasmic reticulum (GO:0072599)6.74703569
10protein localization to endoplasmic reticulum (GO:0070972)6.71201561
11DNA deamination (GO:0045006)6.66839963
12viral life cycle (GO:0019058)6.37477423
13cellular protein complex disassembly (GO:0043624)6.31409055
14maturation of SSU-rRNA (GO:0030490)6.03158832
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.02831849
16ribosomal large subunit biogenesis (GO:0042273)5.97014311
17translational initiation (GO:0006413)5.85799641
18protein complex disassembly (GO:0043241)5.47983166
19macromolecular complex disassembly (GO:0032984)5.17780004
20translation (GO:0006412)4.76076418
21protein targeting to membrane (GO:0006612)4.73126540
22ribonucleoprotein complex biogenesis (GO:0022613)4.26685288
23nuclear-transcribed mRNA catabolic process (GO:0000956)4.24917342
24mRNA catabolic process (GO:0006402)4.05359532
25energy coupled proton transport, down electrochemical gradient (GO:0015985)3.95575335
26ATP synthesis coupled proton transport (GO:0015986)3.95575335
27deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.92451732
28heme biosynthetic process (GO:0006783)3.88465878
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.85901778
30RNA catabolic process (GO:0006401)3.81163847
31proteasome assembly (GO:0043248)3.81047508
32negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.80305746
33ncRNA 3-end processing (GO:0043628)3.79653682
34lipoxygenase pathway (GO:0019372)3.66379773
35low-density lipoprotein particle clearance (GO:0034383)3.54127890
36cellular component biogenesis (GO:0044085)3.53243750
37L-phenylalanine metabolic process (GO:0006558)3.52737644
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.52737644
39rRNA processing (GO:0006364)3.48661926
40protein maturation by protein folding (GO:0022417)3.48416468
41telomere maintenance via semi-conservative replication (GO:0032201)3.47861721
42rRNA metabolic process (GO:0016072)3.42793321
43mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.42581456
44pseudouridine synthesis (GO:0001522)3.41775346
45establishment of protein localization to membrane (GO:0090150)3.32053032
46DNA strand elongation involved in DNA replication (GO:0006271)3.30036681
47respiratory electron transport chain (GO:0022904)3.29340913
48electron transport chain (GO:0022900)3.19442683
49regulation of water loss via skin (GO:0033561)3.16854639
50protein targeting (GO:0006605)3.14978019
51regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.13855637
52positive regulation of Cdc42 GTPase activity (GO:0043089)3.10588344
53DNA strand elongation (GO:0022616)3.10470656
54heme metabolic process (GO:0042168)3.10306591
55transcription elongation from RNA polymerase III promoter (GO:0006385)3.05585697
56termination of RNA polymerase III transcription (GO:0006386)3.05585697
57glucose catabolic process (GO:0006007)3.00245402
58exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97165679
59iron-sulfur cluster assembly (GO:0016226)2.95665936
60metallo-sulfur cluster assembly (GO:0031163)2.95665936
61primary alcohol catabolic process (GO:0034310)2.95189121
62establishment of protein localization to organelle (GO:0072594)2.93537451
63amyloid precursor protein catabolic process (GO:0042987)2.92148008
64protoporphyrinogen IX metabolic process (GO:0046501)2.91198105
65antibacterial humoral response (GO:0019731)2.90124960
66telomere maintenance via recombination (GO:0000722)2.83350045
67nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.82978039
68respiratory chain complex IV assembly (GO:0008535)2.82723221
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.82654153
70neutrophil activation involved in immune response (GO:0002283)2.82618452
71antimicrobial humoral response (GO:0019730)2.80658297
72pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.79070634
73positive regulation of cellular amine metabolic process (GO:0033240)2.78496915
74establishment of skin barrier (GO:0061436)2.78033284
75L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.77400247
76spliceosomal snRNP assembly (GO:0000387)2.76399485
77porphyrin-containing compound biosynthetic process (GO:0006779)2.75945852
78negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.75599071
79Arp2/3 complex-mediated actin nucleation (GO:0034314)2.75515972
80deoxyribonucleotide catabolic process (GO:0009264)2.74859238
81pentose metabolic process (GO:0019321)2.74518904
82triglyceride catabolic process (GO:0019433)2.72927538
83NADPH regeneration (GO:0006740)2.71946158
84mitotic nuclear envelope reassembly (GO:0007084)2.70355234
85nuclear envelope reassembly (GO:0031468)2.70355234
86antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.69954441
87negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.69399299
88DNA replication checkpoint (GO:0000076)2.69214451
89hydrogen peroxide catabolic process (GO:0042744)2.66955100
90desmosome organization (GO:0002934)2.65984390
91protoporphyrinogen IX biosynthetic process (GO:0006782)2.64695529
92regulation of integrin-mediated signaling pathway (GO:2001044)2.61946182
93pentose-phosphate shunt (GO:0006098)2.61036707
94ethanol metabolic process (GO:0006067)2.61023070
95regulation of cell proliferation involved in kidney development (GO:1901722)2.60955272
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.60634677
97negative regulation of ligase activity (GO:0051352)2.60634677
98L-phenylalanine catabolic process (GO:0006559)2.60056053
99erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.60056053
100regulation of mitochondrial translation (GO:0070129)2.58927742
101cellular response to arsenic-containing substance (GO:0071243)2.57915265
102positive regulation of keratinocyte differentiation (GO:0045618)2.57504244
103peptidyl-histidine modification (GO:0018202)2.57124543
104protein targeting to mitochondrion (GO:0006626)2.56178268
105Golgi transport vesicle coating (GO:0048200)2.56072671
106COPI coating of Golgi vesicle (GO:0048205)2.56072671
107DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.55853417
108viral protein processing (GO:0019082)2.55770379
109NADH metabolic process (GO:0006734)2.55621112
110formation of translation preinitiation complex (GO:0001731)2.55619517
111virion assembly (GO:0019068)2.55411871
112protein localization to membrane (GO:0072657)2.54477921
113cellular response to zinc ion (GO:0071294)2.54074164
114protein complex biogenesis (GO:0070271)2.53410516
115glutathione metabolic process (GO:0006749)2.53340761
116GTP biosynthetic process (GO:0006183)2.53120744
117multicellular organismal water homeostasis (GO:0050891)2.51671919
118negative regulation of granulocyte differentiation (GO:0030853)2.50742373
119nitrogen cycle metabolic process (GO:0071941)2.50496229
120glutathione biosynthetic process (GO:0006750)2.50231420
121signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.49651079
122intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.49651079
123GDP-mannose metabolic process (GO:0019673)2.49338883
124spliceosomal complex assembly (GO:0000245)2.48932487
125glutathione derivative biosynthetic process (GO:1901687)2.48747444
126glutathione derivative metabolic process (GO:1901685)2.48747444
127deoxyribose phosphate catabolic process (GO:0046386)2.48656333
128telomere maintenance via telomere lengthening (GO:0010833)2.48082936
129fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.48065394
130regulation of cellular amino acid metabolic process (GO:0006521)2.47983178
131negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.47808465
132mitochondrial respiratory chain complex assembly (GO:0033108)2.47216088
133regulation of metalloenzyme activity (GO:0048552)2.46962893
134signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.46875460
135signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.46875460
136signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.46875460
137establishment of protein localization to mitochondrion (GO:0072655)2.46566663
138mitotic recombination (GO:0006312)2.46227895
139tetrapyrrole biosynthetic process (GO:0033014)2.45839027
140positive regulation of lipoprotein lipase activity (GO:0051006)2.45406079
141positive regulation of triglyceride lipase activity (GO:0061365)2.45406079
142negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.45094861
143signal transduction involved in DNA integrity checkpoint (GO:0072401)2.44654061
144signal transduction involved in DNA damage checkpoint (GO:0072422)2.44654061
145antigen processing and presentation via MHC class Ib (GO:0002475)2.44219018
146nucleotide-excision repair, DNA gap filling (GO:0006297)2.44054857
147primary alcohol metabolic process (GO:0034308)2.43113234
148keratan sulfate catabolic process (GO:0042340)2.42821284
149urea cycle (GO:0000050)2.42146205
150peroxisome fission (GO:0016559)2.42092452
151autophagic vacuole fusion (GO:0000046)2.37650433
152norepinephrine metabolic process (GO:0042415)2.37081164
153neutral lipid catabolic process (GO:0046461)2.36400747
154acylglycerol catabolic process (GO:0046464)2.36400747
155endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.34908532
156extracellular fibril organization (GO:0043206)2.32364451
157daunorubicin metabolic process (GO:0044597)2.31818024
158polyketide metabolic process (GO:0030638)2.31818024
159doxorubicin metabolic process (GO:0044598)2.31818024
160positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.31017331
161barbed-end actin filament capping (GO:0051016)2.30440258
162negative regulation of homotypic cell-cell adhesion (GO:0034111)2.29240718
163negative regulation of stress fiber assembly (GO:0051497)2.27817445
164nitric oxide biosynthetic process (GO:0006809)2.27744960
165retinol metabolic process (GO:0042572)2.27152924
166negative regulation of adherens junction organization (GO:1903392)2.25924615
167negative regulation of focal adhesion assembly (GO:0051895)2.25924615
168negative regulation of cell junction assembly (GO:1901889)2.25924615
169NADP metabolic process (GO:0006739)2.24152487
170nonribosomal peptide biosynthetic process (GO:0019184)2.24017916
171very long-chain fatty acid metabolic process (GO:0000038)2.23577667
172phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.23124496
173amyloid precursor protein metabolic process (GO:0042982)2.23001609
174fibril organization (GO:0097435)2.22452139
175cellular response to antibiotic (GO:0071236)2.22266851
176negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.21792262
177cyclooxygenase pathway (GO:0019371)2.20632825
178type B pancreatic cell proliferation (GO:0044342)2.20298872
179intestinal epithelial cell development (GO:0060576)2.19720906
180regulation of cholesterol storage (GO:0010885)2.19646059
181biotin metabolic process (GO:0006768)2.18866057
182immunoglobulin mediated immune response (GO:0016064)2.18106341
183mesonephros development (GO:0001823)2.16707101
184urea metabolic process (GO:0019627)2.16324810
185ethanol oxidation (GO:0006069)2.15448210
186endothelial cell chemotaxis (GO:0035767)2.15315497
187water homeostasis (GO:0030104)2.15091362
188antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.14588335
189hepatocyte apoptotic process (GO:0097284)2.14071481
190xenobiotic catabolic process (GO:0042178)2.13574191
191hydrogen peroxide metabolic process (GO:0042743)2.13572036
192positive regulation of protein homodimerization activity (GO:0090073)2.13021145

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.46290251
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.03435561
3E2F7_22180533_ChIP-Seq_HELA_Human3.92566807
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.69298034
5ESR2_21235772_ChIP-Seq_MCF-7_Human3.15713995
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.95114659
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.92256801
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.88330950
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.87442413
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.82380856
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.79871577
12ZNF263_19887448_ChIP-Seq_K562_Human2.75297301
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.75128884
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.70088632
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.64134098
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.61303243
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.55223042
18* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.48676563
19XRN2_22483619_ChIP-Seq_HELA_Human2.38369103
20RACK7_27058665_Chip-Seq_MCF-7_Human2.33885006
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29142463
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.27232648
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.26954675
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24503145
25* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.20331165
26VDR_21846776_ChIP-Seq_THP-1_Human2.13825609
27LXR_22292898_ChIP-Seq_THP-1_Human2.10997649
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07135166
29* VDR_23849224_ChIP-Seq_CD4+_Human2.04892497
30ELK3_25401928_ChIP-Seq_HUVEC_Human2.03599402
31DCP1A_22483619_ChIP-Seq_HELA_Human2.02624406
32FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.01764555
33TP63_17297297_ChIP-ChIP_HaCaT_Human2.01627548
34CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.01022885
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.95543008
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.95496307
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93933770
38RXR_22158963_ChIP-Seq_LIVER_Mouse1.93712109
39* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92952601
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90474458
41PPARA_22158963_ChIP-Seq_LIVER_Mouse1.88331426
42ESR1_15608294_ChIP-ChIP_MCF-7_Human1.87622409
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.80387874
44FOXP3_21729870_ChIP-Seq_TREG_Human1.73890859
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.68778154
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.67932468
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.66416464
48TTF2_22483619_ChIP-Seq_HELA_Human1.65826250
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64884077
50SRY_22984422_ChIP-ChIP_TESTIS_Rat1.63730807
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62086970
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.61480108
53GABP_19822575_ChIP-Seq_HepG2_Human1.61007367
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.59146147
55* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.57300907
56* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56132222
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53518940
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52979979
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52617928
60P63_26484246_Chip-Seq_KERATINOCYTES_Human1.51007636
61FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.50921624
62FOXM1_23109430_ChIP-Seq_U2OS_Human1.49884572
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.49793682
64RUNX1_27514584_Chip-Seq_MCF-7_Human1.49773451
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.47434653
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.46301350
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45332428
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44221043
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42941624
70SPI1_23547873_ChIP-Seq_NB4_Human1.37188744
71VDR_24763502_ChIP-Seq_THP-1_Human1.37095550
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35499941
73P68_20966046_ChIP-Seq_HELA_Human1.34573121
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34306392
75MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.33843874
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.30073852
77CLOCK_20551151_ChIP-Seq_293T_Human1.28376241
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27409017
79MYC_22102868_ChIP-Seq_BL_Human1.26188566
80ELK1_22589737_ChIP-Seq_MCF10A_Human1.26021223
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25746621
82ATF3_27146783_Chip-Seq_COLON_Human1.25501202
83STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25366519
84ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24692774
85* SOX2_20726797_ChIP-Seq_SW620_Human1.23545923
86* BCOR_27268052_Chip-Seq_Bcells_Human1.22321055
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21849593
88* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20542706
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20245713
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19759582
91* BCL6_27268052_Chip-Seq_Bcells_Human1.19022642
92STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18608067
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18291060
94* GATA3_24758297_ChIP-Seq_MCF-7_Human1.17245375
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16336075
96STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16167654
97* MAF_26560356_Chip-Seq_TH2_Human1.15460925
98SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15405006
99KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15047761
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14683692
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14429329
102* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13954570
103* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13711755
104* SA1_27219007_Chip-Seq_ERYTHROID_Human1.13518227
105CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13105066
106TRIM28_21343339_ChIP-Seq_HEK293_Human1.13029318
107ELK1_19687146_ChIP-ChIP_HELA_Human1.12952436
108SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12935677
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12867096
110PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12315496
111* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11289948
112CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11276828
113CIITA_25753668_ChIP-Seq_RAJI_Human1.10857819
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10689546
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10045165
116GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09386072
117SMC4_20622854_ChIP-Seq_HELA_Human1.08777671
118CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08764745
119KDM5A_27292631_Chip-Seq_BREAST_Human1.08657709
120* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06034349
121RUNX1_22412390_ChIP-Seq_EML_Mouse1.05965905
122* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05859114
123POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05474526
124MAF_26560356_Chip-Seq_TH1_Human1.05461041
125PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04967293
126STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04903075
127* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04722565
128LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04316279
129TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04270572
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03941897
131TCF7_22412390_ChIP-Seq_EML_Mouse1.02885091
132HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02357410
133UTX_26944678_Chip-Seq_JUKART_Human1.01904816
134CTCF_26484167_Chip-Seq_Bcells_Mouse1.01752581
135ELF5_23300383_ChIP-Seq_T47D_Human1.01585322
136TET1_21451524_ChIP-Seq_MESCs_Mouse1.01387637
137* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01161302
138KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00708975
139CTCF_21964334_Chip-Seq_Bcells_Human1.00360393
140NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00171803
141TP63_22573176_ChIP-Seq_HFKS_Human1.00064723
142CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00020990
143CREB1_26743006_Chip-Seq_LNCaP_Human1.00000509
144KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99605621
145MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99085512
146PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98481389
147RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98002646
148ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97795677
149ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.97752961
150SCL_19346495_ChIP-Seq_HPC-7_Human0.97649152
151LXR_22158963_ChIP-Seq_LIVER_Mouse0.97556971
152STAT1_20625510_ChIP-Seq_HELA_Human0.97214026
153MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96831350
154* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96687495
155E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95496580
156BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95195456
157TFEB_21752829_ChIP-Seq_HELA_Human0.94557921
158GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94405073
159CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93651176
160MYC_18940864_ChIP-ChIP_HL60_Human0.93473157
161KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93316834
162* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93290270
163FOXP1_21924763_ChIP-Seq_HESCs_Human0.92529223
164IRF8_22096565_ChIP-ChIP_GC-B_Human0.90905349
165YY1_22570637_ChIP-Seq_MALME-3M_Human0.90352309

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.30842010
2MP0003693_abnormal_embryo_hatching3.25291317
3MP0005670_abnormal_white_adipose3.24182344
4MP0000490_abnormal_crypts_of2.52947575
5MP0005666_abnormal_adipose_tissue2.51179219
6MP0004957_abnormal_blastocyst_morpholog2.48455568
7MP0009333_abnormal_splenocyte_physiolog2.37868757
8MP0004185_abnormal_adipocyte_glucose2.23990111
9MP0003186_abnormal_redox_activity2.23759141
10MP0010234_abnormal_vibrissa_follicle2.20800088
11MP0001873_stomach_inflammation2.13178432
12MP0009780_abnormal_chondrocyte_physiolo2.05792906
13MP0003806_abnormal_nucleotide_metabolis2.03092936
14MP0000685_abnormal_immune_system2.02569310
15MP0009785_altered_susceptibility_to2.02555234
16MP0010155_abnormal_intestine_physiology2.01316975
17MP0002396_abnormal_hematopoietic_system2.00058988
18MP0002132_abnormal_respiratory_system1.97517215
19MP0003705_abnormal_hypodermis_morpholog1.95423321
20MP0004147_increased_porphyrin_level1.94578528
21MP0004381_abnormal_hair_follicle1.93349265
22MP0003656_abnormal_erythrocyte_physiolo1.92511562
23MP0005025_abnormal_response_to1.90483813
24MP0005375_adipose_tissue_phenotype1.87317044
25MP0003436_decreased_susceptibility_to1.83851444
26MP0003763_abnormal_thymus_physiology1.79936970
27MP0005671_abnormal_response_to1.76464779
28MP0008438_abnormal_cutaneous_collagen1.76202332
29MP0001835_abnormal_antigen_presentation1.75944610
30MP0002148_abnormal_hypersensitivity_rea1.74724495
31MP0003866_abnormal_defecation1.71252559
32MP0002139_abnormal_hepatobiliary_system1.70960139
33MP0003724_increased_susceptibility_to1.63594953
34MP0005000_abnormal_immune_tolerance1.63094966
35MP0003111_abnormal_nucleus_morphology1.62923771
36MP0008932_abnormal_embryonic_tissue1.61138699
37MP0002971_abnormal_brown_adipose1.60037414
38MP0003077_abnormal_cell_cycle1.59938720
39MP0003172_abnormal_lysosome_physiology1.58431025
40MP0000858_altered_metastatic_potential1.56827206
41MP0005083_abnormal_biliary_tract1.55939965
42MP0001663_abnormal_digestive_system1.55811945
43MP0002420_abnormal_adaptive_immunity1.55605403
44MP0002398_abnormal_bone_marrow1.54658300
45MP0001819_abnormal_immune_cell1.53936497
46MP0005275_abnormal_skin_tensile1.51357607
47MP0002723_abnormal_immune_serum1.50434267
48MP0002405_respiratory_system_inflammati1.50197202
49MP0002452_abnormal_antigen_presenting1.49082957
50MP0001800_abnormal_humoral_immune1.47705132
51MP0000465_gastrointestinal_hemorrhage1.47465316
52MP0005174_abnormal_tail_pigmentation1.47157408
53MP0002722_abnormal_immune_system1.44819567
54MP0005381_digestive/alimentary_phenotyp1.43357875
55MP0009840_abnormal_foam_cell1.42340842
56MP0000716_abnormal_immune_system1.41785780
57MP0004264_abnormal_extraembryonic_tissu1.40190278
58MP0002429_abnormal_blood_cell1.39103742
59MP0000689_abnormal_spleen_morphology1.38777044
60MP0002166_altered_tumor_susceptibility1.37431736
61MP0001790_abnormal_immune_system1.36567224
62MP0005387_immune_system_phenotype1.36567224
63MP0005075_abnormal_melanosome_morpholog1.36059650
64MP0005501_abnormal_skin_physiology1.35871202
65MP0005397_hematopoietic_system_phenotyp1.34938149
66MP0001545_abnormal_hematopoietic_system1.34938149
67MP0010329_abnormal_lipoprotein_level1.34607464
68MP0010094_abnormal_chromosome_stability1.34218158
69MP0002419_abnormal_innate_immunity1.33190198
70MP0002909_abnormal_adrenal_gland1.31954928
71MP0000477_abnormal_intestine_morphology1.27557050
72MP0005365_abnormal_bile_salt1.25849218
73MP0008875_abnormal_xenobiotic_pharmacok1.24725601
74MP0006036_abnormal_mitochondrial_physio1.24500698
75MP0001542_abnormal_bone_strength1.23959049
76MP0010030_abnormal_orbit_morphology1.23953557
77MP0004510_myositis1.23628408
78MP0001348_abnormal_lacrimal_gland1.22411163
79MP0003303_peritoneal_inflammation1.20779283
80MP0005503_abnormal_tendon_morphology1.19295169
81MP0000462_abnormal_digestive_system1.19230545
82MP0003453_abnormal_keratinocyte_physiol1.18947045
83MP0001845_abnormal_inflammatory_respons1.18924734
84MP0000703_abnormal_thymus_morphology1.17048014
85MP0002019_abnormal_tumor_incidence1.14950483
86MP0003638_abnormal_response/metabolism_1.14933901
87MP0004947_skin_inflammation1.13387628
88MP0005451_abnormal_body_composition1.12004361
89MP0005636_abnormal_mineral_homeostasis1.11479309
90MP0003566_abnormal_cell_adhesion1.11402888
91MP0004019_abnormal_vitamin_homeostasis1.11307289
92MP0002796_impaired_skin_barrier1.10973832
93MP0001764_abnormal_homeostasis1.10690565
94MP0003075_altered_response_to1.10528067
95MP0003315_abnormal_perineum_morphology1.10102042
96MP0002118_abnormal_lipid_homeostasis1.09056219
97MP0008260_abnormal_autophagy1.08876590
98MP0005464_abnormal_platelet_physiology1.08784096
99MP0009643_abnormal_urine_homeostasis1.08774877
100MP0006082_CNS_inflammation1.07390836
101MP0000613_abnormal_salivary_gland1.06218481
102MP0009384_cardiac_valve_regurgitation1.05729476
103MP0008469_abnormal_protein_level1.03346690
104MP0001853_heart_inflammation1.03066775
105MP0003279_aneurysm1.02275460
106MP0002970_abnormal_white_adipose1.01980053
107MP0002933_joint_inflammation1.01908996
108MP0000003_abnormal_adipose_tissue1.01815233
109MP0000313_abnormal_cell_death1.01497046
110MP0003191_abnormal_cellular_cholesterol1.01397814
111MP0005319_abnormal_enzyme/_coenzyme1.01330302
112MP0008007_abnormal_cellular_replicative1.01320865
113MP0002006_tumorigenesis1.01008219
114MP0010352_gastrointestinal_tract_polyps1.00963084
115MP0010771_integument_phenotype1.00333236
116MP0003136_yellow_coat_color0.98678695
117MP0005334_abnormal_fat_pad0.97699190
118MP0005535_abnormal_body_temperature0.95376465
119MP0005377_hearing/vestibular/ear_phenot0.95193407
120MP0003878_abnormal_ear_physiology0.95193407
121MP0009115_abnormal_fat_cell0.93642303
122MP0003786_premature_aging0.93348946
123MP0001881_abnormal_mammary_gland0.93341006
124MP0008004_abnormal_stomach_pH0.92164992
125MP0005058_abnormal_lysosome_morphology0.91627614
126MP0005165_increased_susceptibility_to0.91576624
127MP0004130_abnormal_muscle_cell0.91053045
128MP0005310_abnormal_salivary_gland0.91045259
129MP0008058_abnormal_DNA_repair0.90445771
130MP0000609_abnormal_liver_physiology0.90044885
131MP0003879_abnormal_hair_cell0.89980998
132MP0003011_delayed_dark_adaptation0.89356219
133MP0003300_gastrointestinal_ulcer0.87870007
134MP0000681_abnormal_thyroid_gland0.87523231
135MP0002098_abnormal_vibrissa_morphology0.87031964
136MP0005408_hypopigmentation0.86932763
137MP0002060_abnormal_skin_morphology0.86580840
138MP0001533_abnormal_skeleton_physiology0.85940466
139MP0001756_abnormal_urination0.84699295
140MP0000678_abnormal_parathyroid_gland0.84370720
141MP0005584_abnormal_enzyme/coenzyme_acti0.83904012
142MP0002277_abnormal_respiratory_mucosa0.82629097
143MP0002998_abnormal_bone_remodeling0.82202707
144MP0001661_extended_life_span0.81835260
145MP0001664_abnormal_digestion0.81177043
146MP0001216_abnormal_epidermal_layer0.80656128
147MP0005360_urolithiasis0.80646862
148MP0000013_abnormal_adipose_tissue0.80460057
149MP0000538_abnormal_urinary_bladder0.79244909
150MP0005390_skeleton_phenotype0.78560091
151MP0000343_altered_response_to0.77867948
152MP0001849_ear_inflammation0.77729266
153MP0005084_abnormal_gallbladder_morpholo0.76987959
154MP0003718_maternal_effect0.74452365
155MP0002138_abnormal_hepatobiliary_system0.74004436
156MP0000470_abnormal_stomach_morphology0.73824905

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)7.33265663
2Abnormal number of erythroid precursors (HP:0012131)6.63342545
3Reticulocytopenia (HP:0001896)5.87068882
4Macrocytic anemia (HP:0001972)4.93656250
5Pallor (HP:0000980)4.49320576
6Aplasia/Hypoplasia of the sacrum (HP:0008517)4.30322326
7Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.97985862
8Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.92018467
9Decreased activity of mitochondrial respiratory chain (HP:0008972)3.92018467
10Hepatocellular necrosis (HP:0001404)3.74174854
11Mitochondrial inheritance (HP:0001427)3.62333460
12Increased hepatocellular lipid droplets (HP:0006565)3.49917017
13J-shaped sella turcica (HP:0002680)3.48375559
14Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.47047332
15Abnormal hemoglobin (HP:0011902)3.46878979
16Hepatic necrosis (HP:0002605)3.37728682
17Increased intramyocellular lipid droplets (HP:0012240)3.35849887
18Dysostosis multiplex (HP:0000943)3.33526171
19Lipid accumulation in hepatocytes (HP:0006561)3.25877068
20Abnormality of the nasal mucosa (HP:0000433)3.18915784
21Renal Fanconi syndrome (HP:0001994)3.16204976
22Abnormality of glycolipid metabolism (HP:0010969)3.14451440
23Abnormality of liposaccharide metabolism (HP:0010968)3.14451440
24Abnormality of glycosphingolipid metabolism (HP:0004343)3.14451440
25Nasal polyposis (HP:0100582)3.14200282
26Thrombocytosis (HP:0001894)3.09928225
27Acute necrotizing encephalopathy (HP:0006965)3.08610595
28Exertional dyspnea (HP:0002875)3.08388352
29Petechiae (HP:0000967)3.05185560
30Increased muscle lipid content (HP:0009058)3.04804419
31Abnormality of the heme biosynthetic pathway (HP:0010472)3.03387013
32Distal lower limb muscle weakness (HP:0009053)2.99895554
33Pustule (HP:0200039)2.99260646
34Increased CSF lactate (HP:0002490)2.95236486
35Abnormality of aromatic amino acid family metabolism (HP:0004338)2.92945651
36Axonal loss (HP:0003447)2.91780239
37Abnormal mitochondria in muscle tissue (HP:0008316)2.89809217
38Vertebral compression fractures (HP:0002953)2.85089389
39Cervical subluxation (HP:0003308)2.79742355
40Prolonged neonatal jaundice (HP:0006579)2.77873332
413-Methylglutaconic aciduria (HP:0003535)2.74486089
42Trismus (HP:0000211)2.74440935
43Reduced subcutaneous adipose tissue (HP:0003758)2.71636831
44Hypertriglyceridemia (HP:0002155)2.71350855
45Microvesicular hepatic steatosis (HP:0001414)2.71004282
46Acute encephalopathy (HP:0006846)2.70040837
47Growth hormone excess (HP:0000845)2.65796300
48Abnormality of mucopolysaccharide metabolism (HP:0011020)2.64918027
49Abnormality of polysaccharide metabolism (HP:0011012)2.64918027
50Abnormality of glycosaminoglycan metabolism (HP:0004371)2.64918027
51Increased serum lactate (HP:0002151)2.63909489
52Microretrognathia (HP:0000308)2.62251748
53Mucopolysacchariduria (HP:0008155)2.59450032
54Urinary glycosaminoglycan excretion (HP:0003541)2.59450032
55Chronic sinusitis (HP:0011109)2.58675161
56Elevated erythrocyte sedimentation rate (HP:0003565)2.56299239
57Abnormality of the Achilles tendon (HP:0005109)2.56099657
58Testicular atrophy (HP:0000029)2.54839125
59Prolonged bleeding time (HP:0003010)2.53860698
60Acanthosis nigricans (HP:0000956)2.51136141
61Respiratory failure (HP:0002878)2.47900185
62Systemic lupus erythematosus (HP:0002725)2.45358129
63Increased neuronal autofluorescent lipopigment (HP:0002074)2.44300501
64Type I transferrin isoform profile (HP:0003642)2.43192722
65Achilles tendon contracture (HP:0001771)2.39475861
66Chronic otitis media (HP:0000389)2.39261806
67Increased cerebral lipofuscin (HP:0011813)2.37185464
68Abnormality of reticulocytes (HP:0004312)2.35373167
69Oral leukoplakia (HP:0002745)2.33297304
70Progressive neurologic deterioration (HP:0002344)2.32615484
71Hyperparathyroidism (HP:0000843)2.31779308
72Cerebral hypomyelination (HP:0006808)2.30671909
73Lactic acidosis (HP:0003128)2.29971261
74Aplastic anemia (HP:0001915)2.27719362
75Increased serum ferritin (HP:0003281)2.26212169
76Progressive macrocephaly (HP:0004481)2.25516208
77Menorrhagia (HP:0000132)2.25130081
78Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.25113852
79Basal ganglia calcification (HP:0002135)2.22004627
80Hyperphosphaturia (HP:0003109)2.21697425
81IgM deficiency (HP:0002850)2.19167331
82Rough bone trabeculation (HP:0100670)2.18280229
83Poikiloderma (HP:0001029)2.17777258
84Abnormal respiratory epithelium morphology (HP:0012253)2.16848510
85Abnormal respiratory motile cilium morphology (HP:0005938)2.16848510
86Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.16227217
87Exercise intolerance (HP:0003546)2.15608504
88Respiratory difficulties (HP:0002880)2.13126168
89Nuclear cataract (HP:0100018)2.12861800
90Abnormal protein glycosylation (HP:0012346)2.10662222
91Abnormal glycosylation (HP:0012345)2.10662222
92Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.10662222
93Abnormal protein N-linked glycosylation (HP:0012347)2.10662222
94Testicular neoplasm (HP:0010788)2.10556160
95Abnormality of monocarboxylic acid metabolism (HP:0010996)2.10356419
96Vacuolated lymphocytes (HP:0001922)2.10267103
97Ileus (HP:0002595)2.10232051
98Congenital ichthyosiform erythroderma (HP:0007431)2.07691477
99Progressive muscle weakness (HP:0003323)2.07134762
100Gingival bleeding (HP:0000225)2.05143811
101Amniotic constriction ring (HP:0009775)2.05075768
102Abnormality of placental membranes (HP:0011409)2.05075768
103Recurrent abscess formation (HP:0002722)2.04215903
104Abnormal ciliary motility (HP:0012262)2.03993704
105Breast hypoplasia (HP:0003187)2.02759957
106Abnormality of renal resorption (HP:0011038)2.02326016
107Abnormality of macrophages (HP:0004311)2.00110300
108Poor head control (HP:0002421)1.99520900
109Pancytopenia (HP:0001876)1.99224684
110Long toe (HP:0010511)1.97672454
111Abnormality of fatty-acid metabolism (HP:0004359)1.96937297
112Flat capital femoral epiphysis (HP:0003370)1.96560651
113Concave nail (HP:0001598)1.96478665
114Reduced antithrombin III activity (HP:0001976)1.94675702
115Microcytic anemia (HP:0001935)1.94294841
116Xanthomatosis (HP:0000991)1.93719171
117Joint stiffness (HP:0001387)1.93105273
118Dicarboxylic aciduria (HP:0003215)1.93053922
119Abnormality of dicarboxylic acid metabolism (HP:0010995)1.93053922
120Dynein arm defect of respiratory motile cilia (HP:0012255)1.92818704
121Absent/shortened dynein arms (HP:0200106)1.92818704
122Erythema (HP:0010783)1.92623471
123Epistaxis (HP:0000421)1.92378654
124Paralysis (HP:0003470)1.92285622
125Cerebral edema (HP:0002181)1.92185983
126Bulbar palsy (HP:0001283)1.92048354
127Stridor (HP:0010307)1.90317489
128Abnormal respiratory motile cilium physiology (HP:0012261)1.87203440
129Cheilitis (HP:0100825)1.86007106
130Bone cyst (HP:0012062)1.85486260
131Asplenia (HP:0001746)1.85451511
132Purpura (HP:0000979)1.85054075
133Abnormality of T cell physiology (HP:0011840)1.83660950
134Cardiomegaly (HP:0001640)1.83411085
135Parakeratosis (HP:0001036)1.81599173
136Partial duplication of thumb phalanx (HP:0009944)1.80823713
137Large eyes (HP:0001090)1.80652390
138Hypercortisolism (HP:0001578)1.79762275
139Abnormal urine phosphate concentration (HP:0012599)1.78781853
140Eczematoid dermatitis (HP:0000976)1.78090762
141Absent thumb (HP:0009777)1.77465077
142Hypoplasia of the radius (HP:0002984)1.76970956
143Glycosuria (HP:0003076)1.76687793
144Abnormality of urine glucose concentration (HP:0011016)1.76687793
145Sparse lateral eyebrow (HP:0005338)1.76438950
146Rhabdomyolysis (HP:0003201)1.76356303
147Abnormality of magnesium homeostasis (HP:0004921)1.75872602
148Glomerulonephritis (HP:0000099)1.75178913
149Abnormality of the distal phalanges of the toes (HP:0010182)1.74900176
150Oligomenorrhea (HP:0000876)1.74802016
151Severe combined immunodeficiency (HP:0004430)1.74717320
152Stenosis of the external auditory canal (HP:0000402)1.74586690
153Aplasia/hypoplasia of the uterus (HP:0008684)1.74146432
154Partial duplication of the phalanx of hand (HP:0009999)1.73903404
155Sparse eyelashes (HP:0000653)1.73796250
156Vascular calcification (HP:0004934)1.73595026
157Septate vagina (HP:0001153)1.73255043
158Seborrheic dermatitis (HP:0001051)1.72998626
159Granulocytopenia (HP:0001913)1.72603365
160Obstructive lung disease (HP:0006536)1.71774913
161Chronic obstructive pulmonary disease (HP:0006510)1.71774913
162Cerebral palsy (HP:0100021)1.71691928
163Elbow flexion contracture (HP:0002987)1.71582655
164Hyperlipoproteinemia (HP:0010980)1.70452937
165Cutaneous photosensitivity (HP:0000992)1.69777060
166Hyperammonemia (HP:0001987)1.68561098
167Osteolytic defects of the phalanges of the hand (HP:0009771)1.68464986
168Osteolytic defects of the hand bones (HP:0009699)1.68464986
16911 pairs of ribs (HP:0000878)1.67206438
170Hemorrhage of the eye (HP:0011885)1.66937382
171Premature rupture of membranes (HP:0001788)1.66850258
172Broad face (HP:0000283)1.66239957
173Hepatosplenomegaly (HP:0001433)1.66161442
174Depressed nasal ridge (HP:0000457)1.65936264
175Hyperthyroidism (HP:0000836)1.65869911
176Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.65729990
177Urticaria (HP:0001025)1.63365493
178Aplasia/Hypoplasia of the spleen (HP:0010451)1.62470677
179Panhypogammaglobulinemia (HP:0003139)1.62317797

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.04673783
2NME24.95937364
3TRIB33.90846173
4EIF2AK13.24939019
5TESK23.12155161
6BUB13.03833844
7SIK12.80914151
8STK162.67556465
9PIM22.58284479
10VRK22.56489184
11MYLK2.49401187
12MAP4K12.16776837
13BLK2.13355487
14CDK192.06487326
15MUSK1.82270978
16MAP3K31.78390273
17PKN21.72560558
18MAP3K111.69454740
19PBK1.68262616
20RPS6KB21.66340897
21SMG11.62227828
22KDR1.59949671
23VRK11.56492440
24TNK21.53917898
25EIF2AK31.53633243
26MAP2K21.49115946
27WEE11.46508310
28NME11.45265422
29LRRK21.43822040
30IRAK31.43285941
31TAOK11.43071475
32MST41.37532532
33IRAK41.36685310
34ERN11.36070147
35DAPK31.31781850
36MST1R1.30951925
37MAP3K121.28667712
38ILK1.26243796
39TGFBR21.15401390
40BCKDK1.15163570
41STK391.15050521
42TEC1.14539682
43CLK11.14020362
44TAOK21.10606828
45SRPK11.09454465
46TESK11.06892934
47DYRK31.05443132
48PIM11.03565889
49FER1.00657426
50STK100.97279183
51MAP3K100.95205909
52RPS6KA40.94182635
53GRK50.93520363
54PTK20.92395683
55TBK10.91776373
56LIMK10.91404220
57BTK0.91387459
58ABL20.90927144
59IKBKB0.90611736
60MKNK20.90437691
61ZAP700.90330099
62AURKB0.89841797
63MAP3K80.89833236
64CDK70.87657320
65OXSR10.87495001
66PTK60.87302141
67STK40.87260415
68BMX0.86723771
69RPS6KA50.86539202
70BRAF0.85546849
71MAPK150.85397569
72PDPK10.85141585
73PAK10.84637782
74GRK70.84094761
75KIT0.83736766
76PRKD20.82033345
77IKBKE0.81684436
78SCYL20.79880579
79CHUK0.79178942
80AURKA0.77827800
81PAK40.77702892
82MKNK10.77236432
83EPHB10.76412481
84BRSK20.75091583
85EPHB20.74947607
86MAP2K10.74062747
87RIPK40.73905609
88MAP2K30.73481114
89EPHA20.73010859
90HIPK20.71650985
91GRK60.70856665
92TXK0.69945879
93PRKG20.68238670
94PIK3CA0.67720248
95MAPKAPK30.66998153
96DDR20.66733103
97PRKD10.63840574
98NEK20.63439016
99MOS0.62043679
100EEF2K0.61016018
101IRAK20.60669940
102CDK80.60322987
103LMTK20.59955759
104PLK10.58992838
105CDC70.57499246
106FLT30.56343730
107RPS6KA20.56326305
108CAMK2G0.56303620
109MAP3K10.56222219
110MET0.55475638
111TAOK30.55172985
112LYN0.54226267
113TYK20.53145550
114MAPKAPK50.52480444
115CSF1R0.52281698
116WNK40.50552562
117PIK3CG0.48809964
118RPS6KC10.48621410
119RPS6KL10.48621410
120PLK40.47851144
121TTK0.47743021
122MAPK120.47325212
123NLK0.47160339
124SYK0.45925918
125LCK0.45756911
126TNIK0.45520969
127PDK10.44840730
128DYRK1B0.44681580
129PRKD30.44427382
130PRKCI0.43582962
131CDK90.43098617
132CSNK2A10.42392913
133RIPK10.42014810
134MAP2K60.41661723
135ROCK20.41238629
136CSNK2A20.40343743
137CDC42BPA0.39613664
138BRSK10.39488509
139AKT20.38560828
140MAPKAPK20.37298687
141CSK0.36461997
142ADRBK10.35065751
143IRAK10.35022288
144MARK30.34419396
145CDK40.34329219
146RPS6KA60.33501971
147MAPK110.32947601
148PRKCD0.32325503
149DAPK10.31514824
150ARAF0.31160115
151MAPK70.29482528
152PRKAA20.28342588
153MTOR0.27341492
154GSK3A0.26272483

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.69736772
2DNA replication_Homo sapiens_hsa030303.40887537
3Oxidative phosphorylation_Homo sapiens_hsa001903.01924481
4Proteasome_Homo sapiens_hsa030502.96775358
5Sulfur relay system_Homo sapiens_hsa041222.76021072
6Parkinsons disease_Homo sapiens_hsa050122.70039756
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.63455566
8RNA polymerase_Homo sapiens_hsa030202.61303062
9Mismatch repair_Homo sapiens_hsa034302.44817391
10Protein export_Homo sapiens_hsa030602.21427624
11Lysosome_Homo sapiens_hsa041422.17975376
12Homologous recombination_Homo sapiens_hsa034402.17104206
13Spliceosome_Homo sapiens_hsa030402.13832707
14Phenylalanine metabolism_Homo sapiens_hsa003602.11650914
15Tyrosine metabolism_Homo sapiens_hsa003502.08601780
16Pyrimidine metabolism_Homo sapiens_hsa002402.07897372
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.98682634
18Sulfur metabolism_Homo sapiens_hsa009201.89460970
19Base excision repair_Homo sapiens_hsa034101.87757993
20PPAR signaling pathway_Homo sapiens_hsa033201.87152730
21Alzheimers disease_Homo sapiens_hsa050101.86321821
22Huntingtons disease_Homo sapiens_hsa050161.85710099
23Nucleotide excision repair_Homo sapiens_hsa034201.80861609
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79646307
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.79186352
26Folate biosynthesis_Homo sapiens_hsa007901.70181153
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.70057026
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.67806006
29beta-Alanine metabolism_Homo sapiens_hsa004101.56176239
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.47496750
31Retinol metabolism_Homo sapiens_hsa008301.41553525
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.38645100
33Fatty acid degradation_Homo sapiens_hsa000711.37936054
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.34442688
35Primary immunodeficiency_Homo sapiens_hsa053401.31740759
36Glutathione metabolism_Homo sapiens_hsa004801.26208188
37One carbon pool by folate_Homo sapiens_hsa006701.24593281
38Vibrio cholerae infection_Homo sapiens_hsa051101.23829378
39Collecting duct acid secretion_Homo sapiens_hsa049661.21633436
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.20689578
41Pentose phosphate pathway_Homo sapiens_hsa000301.18257336
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14670017
43* Systemic lupus erythematosus_Homo sapiens_hsa053221.13121928
44Other glycan degradation_Homo sapiens_hsa005111.08477486
45Fanconi anemia pathway_Homo sapiens_hsa034601.06360348
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05700521
47Glycerolipid metabolism_Homo sapiens_hsa005610.97273669
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94648915
49Purine metabolism_Homo sapiens_hsa002300.91465935
50Mineral absorption_Homo sapiens_hsa049780.91221902
51Arachidonic acid metabolism_Homo sapiens_hsa005900.91059429
52p53 signaling pathway_Homo sapiens_hsa041150.90668046
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.89937525
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89732558
55Non-homologous end-joining_Homo sapiens_hsa034500.89617924
56RNA transport_Homo sapiens_hsa030130.88945400
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88474532
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88409646
59Fatty acid metabolism_Homo sapiens_hsa012120.87440958
60Cell cycle_Homo sapiens_hsa041100.85514416
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.79846189
62Basal transcription factors_Homo sapiens_hsa030220.78271361
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76926543
64Rheumatoid arthritis_Homo sapiens_hsa053230.75950137
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75464273
66RNA degradation_Homo sapiens_hsa030180.75291462
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73755760
68Sphingolipid metabolism_Homo sapiens_hsa006000.73405917
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.72970223
70Staphylococcus aureus infection_Homo sapiens_hsa051500.72451138
71Hematopoietic cell lineage_Homo sapiens_hsa046400.71916917
72Renin-angiotensin system_Homo sapiens_hsa046140.70960121
73Antigen processing and presentation_Homo sapiens_hsa046120.69059115
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69003193
75Endocytosis_Homo sapiens_hsa041440.68213409
76Hepatitis C_Homo sapiens_hsa051600.66471357
77Phagosome_Homo sapiens_hsa041450.66325417
78Metabolic pathways_Homo sapiens_hsa011000.66215504
79N-Glycan biosynthesis_Homo sapiens_hsa005100.65123618
80Insulin resistance_Homo sapiens_hsa049310.64343592
81Linoleic acid metabolism_Homo sapiens_hsa005910.64002414
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62484517
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62272505
84Fatty acid elongation_Homo sapiens_hsa000620.62164708
85Tryptophan metabolism_Homo sapiens_hsa003800.61905622
86Bladder cancer_Homo sapiens_hsa052190.60844239
87Platelet activation_Homo sapiens_hsa046110.60388105
88Starch and sucrose metabolism_Homo sapiens_hsa005000.57373606
89Arginine biosynthesis_Homo sapiens_hsa002200.56043388
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55321983
91AMPK signaling pathway_Homo sapiens_hsa041520.55159413
92Shigellosis_Homo sapiens_hsa051310.54308470
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54095831
94Cardiac muscle contraction_Homo sapiens_hsa042600.54012542
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53784718
96Arginine and proline metabolism_Homo sapiens_hsa003300.53143695
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53105648
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52461304
99Malaria_Homo sapiens_hsa051440.52287818
100Herpes simplex infection_Homo sapiens_hsa051680.51875948
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.51199575
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50541453
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50458886
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50315446
105Leishmaniasis_Homo sapiens_hsa051400.49327804
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.49294856
107Pyruvate metabolism_Homo sapiens_hsa006200.49079962
108Fructose and mannose metabolism_Homo sapiens_hsa000510.48700442
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.48593260
110Acute myeloid leukemia_Homo sapiens_hsa052210.47326610
111Apoptosis_Homo sapiens_hsa042100.47326476
112Fatty acid biosynthesis_Homo sapiens_hsa000610.46667359
113Epstein-Barr virus infection_Homo sapiens_hsa051690.45702051
114Complement and coagulation cascades_Homo sapiens_hsa046100.44600583
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.43299124
116Histidine metabolism_Homo sapiens_hsa003400.40819837
117Asthma_Homo sapiens_hsa053100.40393919
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37151494
119Amoebiasis_Homo sapiens_hsa051460.36831090
120Insulin signaling pathway_Homo sapiens_hsa049100.36015994
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35892126
122Measles_Homo sapiens_hsa051620.35661960
123Ether lipid metabolism_Homo sapiens_hsa005650.34616083
124Cysteine and methionine metabolism_Homo sapiens_hsa002700.34546372
125Galactose metabolism_Homo sapiens_hsa000520.34464115
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34359717
127Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34347104
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33460050
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33236286
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31300306
131Viral carcinogenesis_Homo sapiens_hsa052030.30825027
132Thyroid cancer_Homo sapiens_hsa052160.30161616
133Selenocompound metabolism_Homo sapiens_hsa004500.29837415
134Chemical carcinogenesis_Homo sapiens_hsa052040.29750986
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.29408569
136Steroid biosynthesis_Homo sapiens_hsa001000.28734755
137B cell receptor signaling pathway_Homo sapiens_hsa046620.28581728
138Pertussis_Homo sapiens_hsa051330.28054454
139Allograft rejection_Homo sapiens_hsa053300.27928159
140Salmonella infection_Homo sapiens_hsa051320.27835915
141Carbon metabolism_Homo sapiens_hsa012000.27497170
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27293039
143Fat digestion and absorption_Homo sapiens_hsa049750.26291426
144Peroxisome_Homo sapiens_hsa041460.26276956
145Graft-versus-host disease_Homo sapiens_hsa053320.26174768
146Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25159082

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