H2AFX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.27018114
2protein localization to kinetochore (GO:0034501)5.16835544
3DNA replication-dependent nucleosome organization (GO:0034723)5.10001813
4DNA replication-dependent nucleosome assembly (GO:0006335)5.10001813
5DNA strand elongation involved in DNA replication (GO:0006271)4.87494697
6regulation of mammary gland epithelial cell proliferation (GO:0033599)4.72855406
7protein localization to chromosome, centromeric region (GO:0071459)4.68312611
8mitotic sister chromatid segregation (GO:0000070)4.64055034
9DNA strand elongation (GO:0022616)4.62521391
10DNA replication initiation (GO:0006270)4.62189306
11telomere maintenance via semi-conservative replication (GO:0032201)4.52920049
12sister chromatid segregation (GO:0000819)4.28409864
13DNA replication checkpoint (GO:0000076)4.22088886
14viral transcription (GO:0019083)4.13230253
15ribosomal small subunit assembly (GO:0000028)4.11780421
16mitotic nuclear envelope disassembly (GO:0007077)4.08639037
17mitotic metaphase plate congression (GO:0007080)4.06230057
18translational termination (GO:0006415)4.02299219
19peptidyl-arginine omega-N-methylation (GO:0035247)3.99478232
20regulation of histone H3-K9 methylation (GO:0051570)3.94995807
21formation of translation preinitiation complex (GO:0001731)3.93185492
22proline biosynthetic process (GO:0006561)3.91907126
23telomere maintenance via recombination (GO:0000722)3.89816580
24kinetochore organization (GO:0051383)3.88249417
25mitotic recombination (GO:0006312)3.85603436
26maturation of SSU-rRNA (GO:0030490)3.83995712
27regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.81688564
28mitotic chromosome condensation (GO:0007076)3.80362554
29chromatin remodeling at centromere (GO:0031055)3.80127603
30spliceosomal tri-snRNP complex assembly (GO:0000244)3.78830613
31membrane disassembly (GO:0030397)3.78356272
32nuclear envelope disassembly (GO:0051081)3.78356272
33CENP-A containing nucleosome assembly (GO:0034080)3.78021237
34folic acid-containing compound biosynthetic process (GO:0009396)3.76222239
35regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.68867884
36DNA topological change (GO:0006265)3.68779264
37translational elongation (GO:0006414)3.66580523
38chromatin assembly or disassembly (GO:0006333)3.64133696
39protein complex localization (GO:0031503)3.64084196
40telomere maintenance via telomere lengthening (GO:0010833)3.63326194
41regulation of translational fidelity (GO:0006450)3.62803480
42chromatin assembly (GO:0031497)3.61810004
43metaphase plate congression (GO:0051310)3.60806158
44ribosomal small subunit biogenesis (GO:0042274)3.60227624
45attachment of spindle microtubules to kinetochore (GO:0008608)3.58561963
46nucleotide-excision repair, DNA gap filling (GO:0006297)3.57511321
47translational initiation (GO:0006413)3.56734131
48kinetochore assembly (GO:0051382)3.56624511
49regulation of spindle organization (GO:0090224)3.56590312
50DNA replication-independent nucleosome organization (GO:0034724)3.55631047
51DNA replication-independent nucleosome assembly (GO:0006336)3.55631047
52nucleosome disassembly (GO:0006337)3.52858128
53protein-DNA complex disassembly (GO:0032986)3.52858128
54negative regulation of mRNA processing (GO:0050686)3.51807239
55DNA deamination (GO:0045006)3.50462902
56positive regulation of chromosome segregation (GO:0051984)3.49622526
57nuclear pore organization (GO:0006999)3.49181518
58nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.48033684
59nucleobase biosynthetic process (GO:0046112)3.45520531
60DNA duplex unwinding (GO:0032508)3.43316289
61regulation of gene silencing by miRNA (GO:0060964)3.42482632
62regulation of gene silencing by RNA (GO:0060966)3.42482632
63regulation of posttranscriptional gene silencing (GO:0060147)3.42482632
64DNA geometric change (GO:0032392)3.42220943
65establishment of chromosome localization (GO:0051303)3.39719236
66histone arginine methylation (GO:0034969)3.37054718
67ribosomal large subunit biogenesis (GO:0042273)3.36269656
68protein localization to chromosome (GO:0034502)3.32555482
69cellular protein complex localization (GO:0034629)3.30832674
70negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.30550495
71viral mRNA export from host cell nucleus (GO:0046784)3.30054315
72DNA packaging (GO:0006323)3.30008261
73histone exchange (GO:0043486)3.27964281
74peptidyl-arginine methylation (GO:0018216)3.26714623
75peptidyl-arginine N-methylation (GO:0035246)3.26714623
76regulation of chromosome segregation (GO:0051983)3.26504114
77negative regulation of mRNA metabolic process (GO:1903312)3.25676940
78cellular protein complex disassembly (GO:0043624)3.24990065
79negative regulation of chromosome segregation (GO:0051985)3.23762286
80translesion synthesis (GO:0019985)3.23651440
81IMP biosynthetic process (GO:0006188)3.23398756
82mitotic sister chromatid cohesion (GO:0007064)3.22954930
83nuclear pore complex assembly (GO:0051292)3.22518350
84SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.22468470
85somatic diversification of immune receptors via somatic mutation (GO:0002566)3.19663324
86somatic hypermutation of immunoglobulin genes (GO:0016446)3.19663324
87heterochromatin organization (GO:0070828)3.18355123
88mitotic nuclear envelope reassembly (GO:0007084)3.17747120
89nuclear envelope reassembly (GO:0031468)3.17747120
90apoptotic process involved in morphogenesis (GO:0060561)3.16628316
91protein complex disassembly (GO:0043241)3.15754223
92negative regulation of RNA splicing (GO:0033119)3.14444492
93regulation of chromatin binding (GO:0035561)3.14384797
94negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.13400867
95negative regulation of sister chromatid segregation (GO:0033046)3.13400867
96negative regulation of mitotic sister chromatid separation (GO:2000816)3.13400867
97negative regulation of mitotic sister chromatid segregation (GO:0033048)3.13400867
98cotranslational protein targeting to membrane (GO:0006613)3.13339500
99protein targeting to ER (GO:0045047)3.12636079
100spindle checkpoint (GO:0031577)3.12505556
101spindle assembly checkpoint (GO:0071173)3.12349598
102viral life cycle (GO:0019058)3.11209719
103regulation of sister chromatid cohesion (GO:0007063)3.10799566
104positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.10515573
105positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.10515573
106positive regulation of mitotic sister chromatid separation (GO:1901970)3.10515573
107regulation of translational termination (GO:0006449)3.10355443
108* nucleosome assembly (GO:0006334)3.09553348
109ATP-dependent chromatin remodeling (GO:0043044)3.09424980
110planar cell polarity pathway involved in neural tube closure (GO:0090179)3.07528655
111meiotic chromosome segregation (GO:0045132)3.07433924
112ribonucleoprotein complex biogenesis (GO:0022613)3.07290191
113establishment of integrated proviral latency (GO:0075713)3.06049572
114regulation of centrosome cycle (GO:0046605)3.05171912
115postreplication repair (GO:0006301)3.05017309
116mitotic spindle assembly checkpoint (GO:0007094)3.04628177
117regulation of mitotic metaphase/anaphase transition (GO:0030071)3.04110666
118negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.03629160
119protein K6-linked ubiquitination (GO:0085020)3.03239882
120negative regulation of histone methylation (GO:0031061)3.03136068
121chromosome segregation (GO:0007059)3.02148950
122regulation of mitotic spindle organization (GO:0060236)2.99782141
123DNA conformation change (GO:0071103)2.98820206
124purine nucleobase biosynthetic process (GO:0009113)2.98413681
125chromosome condensation (GO:0030261)2.98095656
126positive regulation of DNA-dependent DNA replication (GO:2000105)2.97292428
127nucleobase-containing small molecule interconversion (GO:0015949)2.97128695
128rRNA transcription (GO:0009303)2.96954065
129mitotic G1 DNA damage checkpoint (GO:0031571)2.96350022
130RNA stabilization (GO:0043489)2.93352263
131mRNA stabilization (GO:0048255)2.93352263
132negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.90536199
133positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.89461580
134deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.83173872
1353-UTR-mediated mRNA stabilization (GO:0070935)2.80675966
136regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.76891683
137DNA synthesis involved in DNA repair (GO:0000731)2.76355224
138Golgi transport vesicle coating (GO:0048200)2.73562750
139COPI coating of Golgi vesicle (GO:0048205)2.73562750
140intracellular estrogen receptor signaling pathway (GO:0030520)2.73155035
141pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.68561745
142G1 DNA damage checkpoint (GO:0044783)2.66310729
143histone phosphorylation (GO:0016572)2.61730877
144base-excision repair (GO:0006284)2.61575772
145establishment of viral latency (GO:0019043)2.58538820
146nuclear envelope organization (GO:0006998)2.58243266
147mitotic G1/S transition checkpoint (GO:0044819)2.57821402
148V(D)J recombination (GO:0033151)2.55231938
149regulation of NFAT protein import into nucleus (GO:0051532)2.53999642

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.71837168
2* FOXM1_23109430_ChIP-Seq_U2OS_Human5.26728650
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.94806788
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.70699077
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.64389681
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.40706269
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.31192754
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80520529
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59982877
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.46699685
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34138796
12* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.28295401
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.20989729
14* XRN2_22483619_ChIP-Seq_HELA_Human2.16604149
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.13025834
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.12585462
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.12482308
18* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.11488091
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.06216720
20MYC_22102868_ChIP-Seq_BL_Human2.04486940
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02834514
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.97685636
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92981268
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91418845
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.90196701
26AR_21909140_ChIP-Seq_LNCAP_Human1.88590645
27* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81890414
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.79761800
29LXR_22292898_ChIP-Seq_THP-1_Human1.78939715
30* VDR_23849224_ChIP-Seq_CD4+_Human1.77605860
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.76016406
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.75348222
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.73714857
34ZNF263_19887448_ChIP-Seq_K562_Human1.69955995
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.69489236
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66009780
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64627299
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.64565657
39* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64067358
40CIITA_25753668_ChIP-Seq_RAJI_Human1.62494631
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62410125
42* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61990586
43* FOXP3_21729870_ChIP-Seq_TREG_Human1.59694810
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58536902
45* TTF2_22483619_ChIP-Seq_HELA_Human1.53767036
46* RACK7_27058665_Chip-Seq_MCF-7_Human1.53214740
47DCP1A_22483619_ChIP-Seq_HELA_Human1.52286035
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.51843337
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50953347
50* VDR_21846776_ChIP-Seq_THP-1_Human1.50402062
51* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.49507598
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49025274
53GABP_19822575_ChIP-Seq_HepG2_Human1.45923882
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44419336
55* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44029983
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43466364
57* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.42928741
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.38796194
59* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38179214
60KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.38043490
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35771392
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.35507054
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.34878263
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34478992
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.32649844
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.31958290
67KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.31615887
68KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.31615887
69KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.31615887
70* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31081663
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30908615
72KDM5A_27292631_Chip-Seq_BREAST_Human1.30295115
73* KDM2B_26808549_Chip-Seq_DND41_Human1.29969724
74TCF7_22412390_ChIP-Seq_EML_Mouse1.28946155
75* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27051689
76* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.25656452
77HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23126681
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22869956
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21874123
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20896205
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18706934
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18521648
83P68_20966046_ChIP-Seq_HELA_Human1.17412750
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16886692
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16725259
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15884063
87* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14685645
88ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13751983
89* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13652094
90TP63_19390658_ChIP-ChIP_HaCaT_Human1.13062892
91SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10809760
92* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08595001
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08125315
94RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07796693
95ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07363197
96ATF3_27146783_Chip-Seq_COLON_Human1.06752661
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05915281
98ELK1_19687146_ChIP-ChIP_HELA_Human1.05813213
99TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04996925
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04456904
101* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03044630
102CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03039380
103* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02964036
104UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02876151
105* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02799531
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01419339
107SA1_27219007_Chip-Seq_ERYTHROID_Human1.01250804
108KDM2B_26808549_Chip-Seq_K562_Human1.00271485
109NCOR1_26117541_ChIP-Seq_K562_Human1.00073593
110CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98475203
111NANOG_21062744_ChIP-ChIP_HESCs_Human0.97546404
112PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97159942
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96825239
114* MAF_26560356_Chip-Seq_TH1_Human0.96731404
115* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.96504127
116* KDM2B_26808549_Chip-Seq_JURKAT_Human0.96107335
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95911155
118CREB1_26743006_Chip-Seq_LNCaP_Human0.95849226
119* SOX2_16153702_ChIP-ChIP_HESCs_Human0.95592896
120TFEB_21752829_ChIP-Seq_HELA_Human0.95512520
121FOXP1_21924763_ChIP-Seq_HESCs_Human0.95502072
122FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94760663
123DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94624835
124SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.94486964
125ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93926522
126* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.91955198
127STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91284696
128* MAF_26560356_Chip-Seq_TH2_Human0.91263536
129* VDR_24763502_ChIP-Seq_THP-1_Human0.89271414
130E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89125213
131SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88846995
132* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88389829
133* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87290275
134* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86442332
135* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86176997
136BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85751585
137* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85720892
138* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83988133
139PADI4_21655091_ChIP-ChIP_MCF-7_Human0.83779058
140TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81969355

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.06421878
2MP0003111_abnormal_nucleus_morphology4.83753070
3* MP0010094_abnormal_chromosome_stability4.39899079
4MP0004957_abnormal_blastocyst_morpholog4.27907881
5MP0003077_abnormal_cell_cycle4.09300117
6MP0008057_abnormal_DNA_replication3.71530848
7MP0008058_abnormal_DNA_repair2.84729917
8MP0008932_abnormal_embryonic_tissue2.67040597
9MP0008007_abnormal_cellular_replicative2.58213649
10MP0005623_abnormal_meninges_morphology2.52323137
11MP0010352_gastrointestinal_tract_polyps2.46317987
12MP0001730_embryonic_growth_arrest2.41498276
13MP0002877_abnormal_melanocyte_morpholog2.40561158
14* MP0000350_abnormal_cell_proliferation2.35984832
15MP0001346_abnormal_lacrimal_gland2.32255976
16MP0003123_paternal_imprinting2.27520487
17MP0002249_abnormal_larynx_morphology2.23576293
18MP0004185_abnormal_adipocyte_glucose2.23238058
19MP0010030_abnormal_orbit_morphology2.13297151
20MP0002396_abnormal_hematopoietic_system2.09557653
21MP0010307_abnormal_tumor_latency2.08532783
22MP0005451_abnormal_body_composition1.96349707
23MP0005076_abnormal_cell_differentiation1.94181555
24MP0001697_abnormal_embryo_size1.91558807
25MP0005380_embryogenesis_phenotype1.86801181
26MP0001672_abnormal_embryogenesis/_devel1.86801181
27MP0002085_abnormal_embryonic_tissue1.83687005
28MP0000490_abnormal_crypts_of1.79229467
29MP0004197_abnormal_fetal_growth/weight/1.77233202
30MP0002080_prenatal_lethality1.74279475
31MP0002084_abnormal_developmental_patter1.73138912
32MP0008877_abnormal_DNA_methylation1.70904298
33MP0003984_embryonic_growth_retardation1.65136371
34MP0010234_abnormal_vibrissa_follicle1.63915406
35MP0000566_synostosis1.63623590
36MP0002086_abnormal_extraembryonic_tissu1.63204639
37MP0002088_abnormal_embryonic_growth/wei1.62153788
38MP0004858_abnormal_nervous_system1.60505946
39MP0000313_abnormal_cell_death1.57461572
40MP0000678_abnormal_parathyroid_gland1.54239388
41MP0003786_premature_aging1.53541651
42MP0004808_abnormal_hematopoietic_stem1.51386989
43MP0004233_abnormal_muscle_weight1.45677547
44* MP0002019_abnormal_tumor_incidence1.43809651
45MP0004133_heterotaxia1.41736859
46MP0002163_abnormal_gland_morphology1.40648561
47MP0003119_abnormal_digestive_system1.38250864
48MP0001293_anophthalmia1.37696995
49MP0002653_abnormal_ependyma_morphology1.37075334
50MP0003121_genomic_imprinting1.33203567
51MP0000703_abnormal_thymus_morphology1.32194619
52MP0005397_hematopoietic_system_phenotyp1.31182121
53MP0001545_abnormal_hematopoietic_system1.31182121
54MP0003942_abnormal_urinary_system1.27022279
55MP0002089_abnormal_postnatal_growth/wei1.25624147
56MP0003890_abnormal_embryonic-extraembry1.23751113
57MP0009278_abnormal_bone_marrow1.23570696
58MP0003705_abnormal_hypodermis_morpholog1.23089684
59MP0000537_abnormal_urethra_morphology1.20441717
60MP0009053_abnormal_anal_canal1.18156843
61MP0000003_abnormal_adipose_tissue1.17600344
62MP0009379_abnormal_foot_pigmentation1.17493184
63MP0000534_abnormal_ureter_morphology1.11998921
64MP0003567_abnormal_fetal_cardiomyocyte1.11518058
65MP0002722_abnormal_immune_system1.11227933
66MP0002796_impaired_skin_barrier1.11165059
67MP0003453_abnormal_keratinocyte_physiol1.10356813
68MP0005257_abnormal_intraocular_pressure1.08510352
69MP0002111_abnormal_tail_morphology1.06659933
70* MP0002210_abnormal_sex_determination1.06593998
71MP0003656_abnormal_erythrocyte_physiolo1.06197582
72* MP0002398_abnormal_bone_marrow1.03553791
73* MP0001145_abnormal_male_reproductive1.01326513
74MP0003315_abnormal_perineum_morphology1.01150153
75MP0003283_abnormal_digestive_organ1.00451032
76MP0003941_abnormal_skin_development0.98172185
77MP0000689_abnormal_spleen_morphology0.97933740
78MP0009672_abnormal_birth_weight0.97838689
79MP0002098_abnormal_vibrissa_morphology0.97110657
80MP0009333_abnormal_splenocyte_physiolog0.96238883
81MP0003385_abnormal_body_wall0.94868966
82MP0009250_abnormal_appendicular_skeleto0.94259119
83MP0006292_abnormal_olfactory_placode0.92667509
84MP0005666_abnormal_adipose_tissue0.92659717
85MP0002234_abnormal_pharynx_morphology0.92212609
86* MP0001929_abnormal_gametogenesis0.91534742
87MP0001348_abnormal_lacrimal_gland0.91172209
88MP0003718_maternal_effect0.90114510
89MP0009703_decreased_birth_body0.89182653
90MP0000762_abnormal_tongue_morphology0.85373952
91MP0000858_altered_metastatic_potential0.85295280
92MP0003806_abnormal_nucleotide_metabolis0.84491441
93MP0005023_abnormal_wound_healing0.83471913
94MP0005375_adipose_tissue_phenotype0.82905396
95MP0001849_ear_inflammation0.82382798
96MP0005501_abnormal_skin_physiology0.81218650
97MP0002092_abnormal_eye_morphology0.80606118
98MP0000358_abnormal_cell_content/0.80489633
99* MP0000653_abnormal_sex_gland0.80244178
100MP0000428_abnormal_craniofacial_morphol0.79659905
101MP0005384_cellular_phenotype0.79431702
102MP0008770_decreased_survivor_rate0.79286757
103* MP0002429_abnormal_blood_cell0.78801198
104MP0004272_abnormal_basement_membrane0.78666126
105MP0008260_abnormal_autophagy0.78353204
106MP0001286_abnormal_eye_development0.78336449
107MP0002116_abnormal_craniofacial_bone0.78153669
108MP0003937_abnormal_limbs/digits/tail_de0.77975316
109MP0005621_abnormal_cell_physiology0.77442410
110MP0002932_abnormal_joint_morphology0.75454127
111MP0002009_preneoplasia0.74707402
112MP0000477_abnormal_intestine_morphology0.74563884
113MP0000681_abnormal_thyroid_gland0.74242475
114MP0001661_extended_life_span0.73756993
115MP0006054_spinal_hemorrhage0.73194049
116MP0003763_abnormal_thymus_physiology0.72963654
117MP0001915_intracranial_hemorrhage0.72627764
118MP0004147_increased_porphyrin_level0.70255823
119MP0001727_abnormal_embryo_implantation0.70040729
120MP0003115_abnormal_respiratory_system0.68290192
121MP0001340_abnormal_eyelid_morphology0.68192937
122MP0002697_abnormal_eye_size0.67262354
123MP0003755_abnormal_palate_morphology0.67251627
124MP0008789_abnormal_olfactory_epithelium0.67166260
125MP0005058_abnormal_lysosome_morphology0.66942742
126MP0002160_abnormal_reproductive_system0.66731875
127MP0003861_abnormal_nervous_system0.66482447
128MP0000049_abnormal_middle_ear0.66225218
129MP0003566_abnormal_cell_adhesion0.65689568
130MP0000685_abnormal_immune_system0.64421807
131MP0004264_abnormal_extraembryonic_tissu0.64024814
132MP0002132_abnormal_respiratory_system0.63102045
133MP0000432_abnormal_head_morphology0.62339178
134MP0002075_abnormal_coat/hair_pigmentati0.61516291
135* MP0002925_abnormal_cardiovascular_devel0.60561726
136MP0002114_abnormal_axial_skeleton0.60333140
137MP0003935_abnormal_craniofacial_develop0.59100496
138MP0000733_abnormal_muscle_development0.59036900

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.45154958
2Reticulocytopenia (HP:0001896)4.40306909
3Abnormal number of erythroid precursors (HP:0012131)4.27097842
4Birth length less than 3rd percentile (HP:0003561)3.93124924
5Breast hypoplasia (HP:0003187)3.85645963
6Broad distal phalanx of finger (HP:0009836)3.64916770
7Ependymoma (HP:0002888)3.62489976
8Medulloblastoma (HP:0002885)3.54372947
9Selective tooth agenesis (HP:0001592)3.44764933
10Ulnar bowing (HP:0003031)3.43567588
11Chromsome breakage (HP:0040012)3.36915979
12Colon cancer (HP:0003003)3.36372459
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.34047711
14Patellar aplasia (HP:0006443)3.27745715
15Aplasia/Hypoplasia of the patella (HP:0006498)3.07110913
16Meckel diverticulum (HP:0002245)2.99243566
17Absent thumb (HP:0009777)2.97916499
18Carpal bone hypoplasia (HP:0001498)2.92846518
19Macrocytic anemia (HP:0001972)2.90431144
20Abnormality of the ileum (HP:0001549)2.88160011
21Impulsivity (HP:0100710)2.86533423
22Absent radius (HP:0003974)2.85653846
23Basal cell carcinoma (HP:0002671)2.85635365
24Pallor (HP:0000980)2.82965456
25Insomnia (HP:0100785)2.81437730
26Rhabdomyosarcoma (HP:0002859)2.80570562
27Abnormality of reticulocytes (HP:0004312)2.75401233
28Oral leukoplakia (HP:0002745)2.75050119
29Abnormality of chromosome stability (HP:0003220)2.67533326
30Increased nuchal translucency (HP:0010880)2.67255547
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.66888922
32Absent forearm bone (HP:0003953)2.65564175
33Aplasia involving forearm bones (HP:0009822)2.65564175
34Septate vagina (HP:0001153)2.64773437
35Abnormal number of incisors (HP:0011064)2.63376069
36Agnosia (HP:0010524)2.62339282
37Long palpebral fissure (HP:0000637)2.60789493
38Duodenal stenosis (HP:0100867)2.58486512
39Small intestinal stenosis (HP:0012848)2.58486512
40Abnormality of the preputium (HP:0100587)2.58029591
41Abnormality of the phalanges of the hallux (HP:0010057)2.56664994
42Supernumerary spleens (HP:0009799)2.52732467
43Rib fusion (HP:0000902)2.51862769
44Progressive muscle weakness (HP:0003323)2.50932773
45Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.48044382
46Short 4th metacarpal (HP:0010044)2.48044382
47Achilles tendon contracture (HP:0001771)2.47745759
48Neoplasm of striated muscle (HP:0009728)2.46360232
49Trismus (HP:0000211)2.46241891
50Abdominal situs inversus (HP:0003363)2.46005170
51Abnormality of abdominal situs (HP:0011620)2.46005170
52Degeneration of anterior horn cells (HP:0002398)2.43794550
53Abnormality of the anterior horn cell (HP:0006802)2.43794550
54Neoplasm of the oral cavity (HP:0100649)2.42399031
55Myelodysplasia (HP:0002863)2.41392237
56Atresia of the external auditory canal (HP:0000413)2.40813890
57Abnormality of the heme biosynthetic pathway (HP:0010472)2.38783688
58Neoplasm of the pancreas (HP:0002894)2.35162844
59Abnormality of the distal phalanx of the thumb (HP:0009617)2.33356644
60Aplasia/Hypoplasia of the sacrum (HP:0008517)2.31653370
61Abnormality of the fetal cardiovascular system (HP:0010948)2.31619318
62Abnormal umbilical cord blood vessels (HP:0011403)2.31619318
63Single umbilical artery (HP:0001195)2.31619318
64Abnormality of the umbilical cord (HP:0010881)2.30657904
65Abnormal lung lobation (HP:0002101)2.30367947
66Astrocytoma (HP:0009592)2.29856995
67Abnormality of the astrocytes (HP:0100707)2.29856995
68Missing ribs (HP:0000921)2.29484598
69Abnormality of the labia minora (HP:0012880)2.28239729
70Aplastic anemia (HP:0001915)2.26011540
7111 pairs of ribs (HP:0000878)2.25951563
72Overlapping toe (HP:0001845)2.25222847
73Tracheoesophageal fistula (HP:0002575)2.25195210
74High pitched voice (HP:0001620)2.23153582
75Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.21639808
76Proximal placement of thumb (HP:0009623)2.20592085
77Abnormality of the duodenum (HP:0002246)2.19049858
78Overriding aorta (HP:0002623)2.18517739
79Aplasia/hypoplasia of the humerus (HP:0006507)2.17993924
80Triphalangeal thumb (HP:0001199)2.15931657
81Ectopic kidney (HP:0000086)2.15805290
82Cafe-au-lait spot (HP:0000957)2.12785961
83Rough bone trabeculation (HP:0100670)2.12517739
84Disproportionate tall stature (HP:0001519)2.12158135
85Duplication of thumb phalanx (HP:0009942)2.12093711
86Self-mutilation (HP:0000742)2.12030507
87Deviation of the thumb (HP:0009603)2.09529146
88Abnormality of the carotid arteries (HP:0005344)2.08519686
89Sloping forehead (HP:0000340)2.07795232
90Unilateral renal agenesis (HP:0000122)2.07157739
91Bone marrow hypocellularity (HP:0005528)2.06552218
92Abnormality of the Achilles tendon (HP:0005109)2.06140357
93Broad face (HP:0000283)2.06080195
94Partial duplication of the phalanx of hand (HP:0009999)2.04262290
95Deep palmar crease (HP:0006191)2.03943893
96Glioma (HP:0009733)2.03832706
97Facial hemangioma (HP:0000329)2.02230081
98Abnormality of the distal phalanges of the toes (HP:0010182)2.02102235
99Patellar dislocation (HP:0002999)2.01528288
100Prominent nose (HP:0000448)2.01333585
101Squamous cell carcinoma (HP:0002860)2.00512315
102Horseshoe kidney (HP:0000085)2.00240514
103Renal duplication (HP:0000075)1.99309192
104Truncus arteriosus (HP:0001660)1.98738537
105Elfin facies (HP:0004428)1.97640560
106Thin ribs (HP:0000883)1.97516195
107Short thumb (HP:0009778)1.96658561
108Premature ovarian failure (HP:0008209)1.96509436
109Abnormality of chromosome segregation (HP:0002916)1.94646900
110Partial duplication of thumb phalanx (HP:0009944)1.94547881
111Asymmetry of the thorax (HP:0001555)1.94090297
112Intestinal fistula (HP:0100819)1.92653078
113Poikilocytosis (HP:0004447)1.90655069
114Cleft eyelid (HP:0000625)1.90423893
115Hemivertebrae (HP:0002937)1.89259419
116Microretrognathia (HP:0000308)1.88716784
117Slender long bone (HP:0003100)1.88466931
118Aplasia/Hypoplasia of the sternum (HP:0006714)1.87745568
119Abnormality of the aortic arch (HP:0012303)1.85899806
120Multiple enchondromatosis (HP:0005701)1.85814014
121Ragged-red muscle fibers (HP:0003200)1.84915176
122Short humerus (HP:0005792)1.84830282
123High anterior hairline (HP:0009890)1.84806844
124Premature graying of hair (HP:0002216)1.84663273
125Hypoplasia of the capital femoral epiphysis (HP:0003090)1.84638395
126Supernumerary bones of the axial skeleton (HP:0009144)1.83829362
127Hypoplasia of the radius (HP:0002984)1.83563772
128Angiofibromas (HP:0010615)1.82979601
129Adenoma sebaceum (HP:0009720)1.82979601
130Shallow orbits (HP:0000586)1.82784879
131Reticulocytosis (HP:0001923)1.82641790
132Cholecystitis (HP:0001082)1.82210814
133Abnormal gallbladder physiology (HP:0012438)1.82210814
134Microvesicular hepatic steatosis (HP:0001414)1.82075562
135Spinal cord lesions (HP:0100561)1.82025141
136Syringomyelia (HP:0003396)1.82025141
137Hyperacusis (HP:0010780)1.81485124
138Asplenia (HP:0001746)1.81168719
139Skin tags (HP:0010609)1.80585909
140Amaurosis fugax (HP:0100576)1.80206392
141Pointed chin (HP:0000307)1.78234993
142Abnormality of the thoracic spine (HP:0100711)1.77415064
143Long eyelashes (HP:0000527)1.76829526
144Flared metaphyses (HP:0003015)1.74944103
145Glossoptosis (HP:0000162)1.74223715
146Abnormality of the parietal bone (HP:0002696)1.73769052
147Bowed forearm bones (HP:0003956)1.72740071
148Bowing of the arm (HP:0006488)1.72740071
149Arnold-Chiari malformation (HP:0002308)1.72539203
150Vaginal fistula (HP:0004320)1.72466928
151Premature rupture of membranes (HP:0001788)1.70739908
152Premature skin wrinkling (HP:0100678)1.70404182
153Turricephaly (HP:0000262)1.69601164
154Abnormality of the fingertips (HP:0001211)1.68265671
155Pseudobulbar signs (HP:0002200)1.68086277
156Flattened epiphyses (HP:0003071)1.65763383
157Abnormal ventriculo-arterial connection (HP:0011563)1.65256179
158Transposition of the great arteries (HP:0001669)1.65256179
159Abnormal connection of the cardiac segments (HP:0011545)1.65256179
160Trigonocephaly (HP:0000243)1.61897352
161Stridor (HP:0010307)1.61522045
162Distal lower limb amyotrophy (HP:0008944)1.61223510
163Sparse lateral eyebrow (HP:0005338)1.60422287
164Abnormality of the calcaneus (HP:0008364)1.59927276
165Genu recurvatum (HP:0002816)1.59234849
166Abnormality of cochlea (HP:0000375)1.58591259
167Rectal prolapse (HP:0002035)1.58583238
168Spastic diplegia (HP:0001264)1.58569797
169Biconcave vertebral bodies (HP:0004586)1.57765297

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.74613512
2SMG14.66468699
3TLK14.57827555
4CDC73.93838037
5MAP3K103.72196150
6WEE13.58357814
7CDK123.32485771
8NEK23.07312573
9VRK22.75449509
10IRAK32.50265864
11CDK192.42168982
12EIF2AK12.18166109
13TTK2.15274059
14PRPF4B2.07792836
15TESK22.07623796
16TAOK22.07351932
17EEF2K2.05442501
18VRK12.02591832
19SIK11.91942484
20RPS6KB21.90275585
21ZAK1.83693544
22PLK11.81056384
23CDK71.81047965
24DYRK31.73590921
25TAF11.68425561
26EPHA21.67410787
27AURKB1.66395804
28NEK11.65651298
29SRPK11.56538320
30CHEK21.56054456
31CDK41.55896076
32STK101.55441037
33MAP3K81.52882194
34PLK41.48835591
35BRSK21.45346081
36AURKA1.44687044
37SCYL21.44227320
38NME21.43566895
39ATR1.39887843
40BRD41.34378409
41PKN21.29883974
42BRSK11.29447974
43ACVR1B1.18657813
44PASK1.16703900
45PAK41.16156278
46ARAF1.12704369
47CHEK11.10369407
48PIM11.10226004
49* STK41.09429004
50RPS6KA51.04777382
51GRK61.02076195
52RPS6KA41.00270265
53TESK10.94971708
54FLT30.94286452
55MAPKAPK30.92756384
56TSSK60.90513570
57MKNK10.89427736
58CCNB10.88875158
59CDK20.87667935
60PLK30.87552674
61ERN10.85781020
62IRAK20.84209823
63MAP3K110.81290581
64PRKD30.81186854
65MKNK20.79834081
66ICK0.78902948
67MAP4K10.78419849
68EIF2AK30.77791868
69CDK90.76682528
70PBK0.74429972
71CDK60.74063261
72LRRK20.73374012
73* ATM0.70847376
74KDR0.69915869
75MAP2K20.69832431
76TTN0.68599155
77PAK10.68008756
78MELK0.67506371
79TRIB30.65556223
80MAP2K30.65108087
81MTOR0.62581802
82STK160.61536887
83AKT20.60927245
84CAMK1D0.59853572
85HIPK20.59084902
86CDK10.59060451
87PTK60.55873459
88KSR20.54882007
89CDK150.54826381
90IRAK40.53935418
91ALK0.52282402
92PRKCI0.52254747
93RPS6KC10.49920313
94RPS6KL10.49920313
95TGFBR10.49894979
96PDGFRA0.49687293
97CDK180.48842825
98CSNK2A20.47444258
99TAOK10.45252641
100FGFR40.43863869
101PTK20.43390260
102CSNK2A10.41450934
103CDK140.40496030
104DAPK10.37142839
105DYRK1B0.34654038
106CDK11A0.34425917
107RPS6KA20.34326602
108MAPK110.32112739
109CLK10.31826756
110PAK20.31332272
111RPS6KA60.30942882
112BRAF0.30784389
113DAPK30.30201912
114STK30.29863213
115ILK0.28225410
116BTK0.27130907
117LATS20.26484052
118MAPK140.26089169
119CDK80.25761769
120BLK0.24622694
121MARK30.24512191
122* PRKDC0.24439002
123PIM20.24403968
124RPS6KA10.23119460
125BMX0.22804427
126AKT10.21852605
127BCKDK0.21589034
128MAPKAPK20.21051549
129CSNK1D0.20994002
130EIF2AK20.20774452
131CSNK1E0.19930518
132MAPK10.19330944

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.21515213
2Mismatch repair_Homo sapiens_hsa034304.44613080
3* Systemic lupus erythematosus_Homo sapiens_hsa053223.81872002
4Ribosome_Homo sapiens_hsa030103.59284500
5Base excision repair_Homo sapiens_hsa034103.26009054
6Spliceosome_Homo sapiens_hsa030403.25475112
7Cell cycle_Homo sapiens_hsa041102.99991086
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.96257602
9Homologous recombination_Homo sapiens_hsa034402.94330318
10RNA transport_Homo sapiens_hsa030132.88444133
11Nucleotide excision repair_Homo sapiens_hsa034202.76256369
12One carbon pool by folate_Homo sapiens_hsa006702.52659353
13RNA polymerase_Homo sapiens_hsa030202.32078395
14Fanconi anemia pathway_Homo sapiens_hsa034602.28568185
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.23766637
16Pyrimidine metabolism_Homo sapiens_hsa002402.08685850
17Proteasome_Homo sapiens_hsa030502.06439523
18* Alcoholism_Homo sapiens_hsa050342.00338085
19Non-homologous end-joining_Homo sapiens_hsa034501.95975165
20mRNA surveillance pathway_Homo sapiens_hsa030151.80074830
21p53 signaling pathway_Homo sapiens_hsa041151.76381686
22Viral carcinogenesis_Homo sapiens_hsa052031.62200197
23RNA degradation_Homo sapiens_hsa030181.54927756
24Basal transcription factors_Homo sapiens_hsa030221.41312449
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.28873452
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19490794
27Oocyte meiosis_Homo sapiens_hsa041141.13576378
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12186348
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10155283
30Sulfur relay system_Homo sapiens_hsa041221.05865676
31Epstein-Barr virus infection_Homo sapiens_hsa051691.05327027
32Glioma_Homo sapiens_hsa052141.03739500
33Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98495989
34HTLV-I infection_Homo sapiens_hsa051660.93879770
35Prion diseases_Homo sapiens_hsa050200.92013899
36Herpes simplex infection_Homo sapiens_hsa051680.90211292
37Purine metabolism_Homo sapiens_hsa002300.89554055
38MicroRNAs in cancer_Homo sapiens_hsa052060.85795619
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83051986
40Cyanoamino acid metabolism_Homo sapiens_hsa004600.81919894
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80308938
42Basal cell carcinoma_Homo sapiens_hsa052170.79935971
43Pentose phosphate pathway_Homo sapiens_hsa000300.79040793
44Biosynthesis of amino acids_Homo sapiens_hsa012300.78077603
45Selenocompound metabolism_Homo sapiens_hsa004500.76611649
46Folate biosynthesis_Homo sapiens_hsa007900.76478976
47Bladder cancer_Homo sapiens_hsa052190.73809285
48VEGF signaling pathway_Homo sapiens_hsa043700.73638080
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71780953
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71541553
51Small cell lung cancer_Homo sapiens_hsa052220.69964008
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.69675995
53Thyroid cancer_Homo sapiens_hsa052160.68966849
54Antigen processing and presentation_Homo sapiens_hsa046120.68694915
55Renal cell carcinoma_Homo sapiens_hsa052110.66279416
56Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65905441
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65847188
58ErbB signaling pathway_Homo sapiens_hsa040120.65453047
59Notch signaling pathway_Homo sapiens_hsa043300.60192270
60AMPK signaling pathway_Homo sapiens_hsa041520.59374686
61Chronic myeloid leukemia_Homo sapiens_hsa052200.58475533
62Hippo signaling pathway_Homo sapiens_hsa043900.58198359
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.58100412
64Primary immunodeficiency_Homo sapiens_hsa053400.57735041
65Renin-angiotensin system_Homo sapiens_hsa046140.55625807
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55543705
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54535758
68Apoptosis_Homo sapiens_hsa042100.54091685
69Hedgehog signaling pathway_Homo sapiens_hsa043400.53129281
70Colorectal cancer_Homo sapiens_hsa052100.52743410
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52669980
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52110687
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50931769
74Insulin signaling pathway_Homo sapiens_hsa049100.49063183
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48116757
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.46268460
77Vibrio cholerae infection_Homo sapiens_hsa051100.45379098
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.44177683
79Non-small cell lung cancer_Homo sapiens_hsa052230.42401160
80Melanogenesis_Homo sapiens_hsa049160.41931994
81Hepatitis B_Homo sapiens_hsa051610.40689868
82TGF-beta signaling pathway_Homo sapiens_hsa043500.38686208
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38091251
84Acute myeloid leukemia_Homo sapiens_hsa052210.35837543
85mTOR signaling pathway_Homo sapiens_hsa041500.35755338
86Lysine degradation_Homo sapiens_hsa003100.35061025
87Shigellosis_Homo sapiens_hsa051310.34912654
88Pathways in cancer_Homo sapiens_hsa052000.34840872
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34739424
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34048652
91Glutathione metabolism_Homo sapiens_hsa004800.33818436
92Vitamin B6 metabolism_Homo sapiens_hsa007500.33188553
93Carbon metabolism_Homo sapiens_hsa012000.32665621
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32326866
95Legionellosis_Homo sapiens_hsa051340.30316387
96N-Glycan biosynthesis_Homo sapiens_hsa005100.27103147
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26892069
98Huntingtons disease_Homo sapiens_hsa050160.26837047
99HIF-1 signaling pathway_Homo sapiens_hsa040660.25462201
100Fructose and mannose metabolism_Homo sapiens_hsa000510.24194737
101Prostate cancer_Homo sapiens_hsa052150.23318200
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22827114
103Wnt signaling pathway_Homo sapiens_hsa043100.22411159
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22017548
105Adherens junction_Homo sapiens_hsa045200.21615639
106Melanoma_Homo sapiens_hsa052180.20740867
107Measles_Homo sapiens_hsa051620.20147422
108B cell receptor signaling pathway_Homo sapiens_hsa046620.19740004
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18705293
110Pancreatic cancer_Homo sapiens_hsa052120.18475112
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.17337635
112FoxO signaling pathway_Homo sapiens_hsa040680.16650803
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14640515
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.14591786
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.13961410
116Proteoglycans in cancer_Homo sapiens_hsa052050.13535107
117Hematopoietic cell lineage_Homo sapiens_hsa046400.12862559
118Endometrial cancer_Homo sapiens_hsa052130.10324956
119Influenza A_Homo sapiens_hsa051640.09883195
120Galactose metabolism_Homo sapiens_hsa000520.09626928
121Viral myocarditis_Homo sapiens_hsa054160.09472862

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