H2AFY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.20910808
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.49809575
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.49809575
4DNA unwinding involved in DNA replication (GO:0006268)5.40204844
5DNA strand elongation involved in DNA replication (GO:0006271)5.31036370
6telomere maintenance via semi-conservative replication (GO:0032201)5.17075209
7response to peptidoglycan (GO:0032494)5.12392312
8DNA strand elongation (GO:0022616)5.08696730
9viral transcription (GO:0019083)4.82509433
10DNA deamination (GO:0045006)4.76413050
11translational termination (GO:0006415)4.64053323
12antigen processing and presentation of endogenous antigen (GO:0019883)4.63549971
13telomere maintenance via recombination (GO:0000722)4.48464651
14DNA replication initiation (GO:0006270)4.33848322
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.21094816
16mitotic recombination (GO:0006312)4.19337890
17translational elongation (GO:0006414)4.15674456
18cotranslational protein targeting to membrane (GO:0006613)4.10779387
19protein targeting to ER (GO:0045047)4.08001410
20positive regulation of B cell differentiation (GO:0045579)4.03222768
21maturation of SSU-rRNA (GO:0030490)3.95650959
22neutrophil activation involved in immune response (GO:0002283)3.94033501
23negative regulation of phagocytosis (GO:0050765)3.93815723
24response to muramyl dipeptide (GO:0032495)3.93510875
25mature B cell differentiation involved in immune response (GO:0002313)3.90426507
26Peyers patch development (GO:0048541)3.89133039
27mucosal-associated lymphoid tissue development (GO:0048537)3.89133039
28establishment of protein localization to endoplasmic reticulum (GO:0072599)3.87822952
29telomere maintenance via telomere lengthening (GO:0010833)3.85129489
30protein localization to endoplasmic reticulum (GO:0070972)3.84780566
31ribosomal small subunit biogenesis (GO:0042274)3.83559277
32nucleotide-excision repair, DNA gap filling (GO:0006297)3.79643019
33nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.75275761
34pinocytosis (GO:0006907)3.74282213
35lymphoid progenitor cell differentiation (GO:0002320)3.68754661
36regulation of mast cell degranulation (GO:0043304)3.67554661
37regulation of leukocyte degranulation (GO:0043300)3.62052026
38viral life cycle (GO:0019058)3.59319984
39detection of other organism (GO:0098543)3.55237560
40cellular protein complex disassembly (GO:0043624)3.54926072
41positive thymic T cell selection (GO:0045059)3.53410100
42detection of bacterium (GO:0016045)3.50244775
43regulation of gamma-delta T cell differentiation (GO:0045586)3.50056798
44regulation of myeloid leukocyte mediated immunity (GO:0002886)3.48145248
45antigen processing and presentation via MHC class Ib (GO:0002475)3.47765117
46translational initiation (GO:0006413)3.47445056
47modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.46888754
48positive regulation by organism of defense response of other organism involved in symbiotic interact3.46888754
49modulation by symbiont of host immune response (GO:0052553)3.46888754
50positive regulation by symbiont of host defense response (GO:0052509)3.46888754
51modulation by symbiont of host defense response (GO:0052031)3.46888754
52modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.46888754
53regulation of gamma-delta T cell activation (GO:0046643)3.46102850
54positive regulation of granulocyte differentiation (GO:0030854)3.43742712
55Arp2/3 complex-mediated actin nucleation (GO:0034314)3.38433332
56cellular extravasation (GO:0045123)3.37304564
57negative regulation of RNA splicing (GO:0033119)3.34934025
58regulation of B cell differentiation (GO:0045577)3.34311139
59protein complex disassembly (GO:0043241)3.33693996
60negative regulation of granulocyte differentiation (GO:0030853)3.29753506
61nucleobase biosynthetic process (GO:0046112)3.28971136
62regulation of mast cell activation involved in immune response (GO:0033006)3.28750857
63IMP biosynthetic process (GO:0006188)3.27397609
64protein localization to kinetochore (GO:0034501)3.26461140
65regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.25842499
66negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.24690268
67IMP metabolic process (GO:0046040)3.23216150
68deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.22990594
69T cell homeostasis (GO:0043029)3.20449475
70translesion synthesis (GO:0019985)3.20187900
71DNA replication checkpoint (GO:0000076)3.20187826
72negative regulation of interleukin-12 production (GO:0032695)3.17853355
73negative regulation of B cell apoptotic process (GO:0002903)3.16979783
74positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.14232947
75mast cell activation (GO:0045576)3.13014316
76response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.12210112
77response to host immune response (GO:0052572)3.12210112
78regulation of B cell receptor signaling pathway (GO:0050855)3.11173902
79macromolecular complex disassembly (GO:0032984)3.11110216
80nuclear-transcribed mRNA catabolic process (GO:0000956)3.10310743
81positive regulation of gamma-delta T cell activation (GO:0046645)3.07092812
82response to host (GO:0075136)3.02829270
83response to host defenses (GO:0052200)3.02829270
84response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.02829270
853-UTR-mediated mRNA stabilization (GO:0070935)3.02033510
86regulation of erythrocyte differentiation (GO:0045646)3.01095428
87regulation of granulocyte differentiation (GO:0030852)2.99466690
88mature B cell differentiation (GO:0002335)2.98561709
89mRNA catabolic process (GO:0006402)2.96421926
90DNA topological change (GO:0006265)2.96315295
91intra-S DNA damage checkpoint (GO:0031573)2.91104664
92definitive hemopoiesis (GO:0060216)2.91010346
93telomere maintenance (GO:0000723)2.90936858
94positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.90586685
95cellular hyperosmotic response (GO:0071474)2.90485762
96RNA catabolic process (GO:0006401)2.89844246
97telomere organization (GO:0032200)2.87456292
98positive regulation of mast cell activation involved in immune response (GO:0033008)2.86432894
99positive regulation of mast cell degranulation (GO:0043306)2.86432894
100ribosomal large subunit biogenesis (GO:0042273)2.85351582
101purine deoxyribonucleotide catabolic process (GO:0009155)2.82409645
102regulation of B cell apoptotic process (GO:0002902)2.82401845
103CENP-A containing nucleosome assembly (GO:0034080)2.82328844
104angiogenesis involved in wound healing (GO:0060055)2.81843813
105poly(A)+ mRNA export from nucleus (GO:0016973)2.79997691
106regulation of monocyte differentiation (GO:0045655)2.79298346
107regulation of regulated secretory pathway (GO:1903305)2.77739571
108negative thymic T cell selection (GO:0045060)2.77657599
109antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.76663049
110regulation of mast cell activation (GO:0033003)2.75006337
111DNA duplex unwinding (GO:0032508)2.74699779
112positive regulation of antigen processing and presentation (GO:0002579)2.73828921
113chromatin remodeling at centromere (GO:0031055)2.73723473
114purine nucleobase biosynthetic process (GO:0009113)2.72005383
115DNA geometric change (GO:0032392)2.71813359
116DNA replication-independent nucleosome assembly (GO:0006336)2.71806933
117DNA replication-independent nucleosome organization (GO:0034724)2.71806933
118protein localization to chromosome, centromeric region (GO:0071459)2.70761169
119negative regulation of mRNA processing (GO:0050686)2.69724756
120negative regulation of erythrocyte differentiation (GO:0045647)2.69111002
121detection of external biotic stimulus (GO:0098581)2.68197792
122formation of translation preinitiation complex (GO:0001731)2.67681399
123chaperone mediated protein folding requiring cofactor (GO:0051085)2.66692203
124myeloid cell activation involved in immune response (GO:0002275)2.66194310
125pseudouridine synthesis (GO:0001522)2.65613922
126positive regulation of mast cell activation (GO:0033005)2.65338303
127macrophage activation involved in immune response (GO:0002281)2.65017987
128immunoglobulin mediated immune response (GO:0016064)2.64791756
129defense response to protozoan (GO:0042832)2.64723207
130mast cell degranulation (GO:0043303)2.64036909
131mast cell activation involved in immune response (GO:0002279)2.64036909
132response to interferon-beta (GO:0035456)2.63134309
133positive regulation of leukocyte degranulation (GO:0043302)2.63114113
134response to protozoan (GO:0001562)2.63068490
135actin nucleation (GO:0045010)2.61224443
136protein targeting to membrane (GO:0006612)2.61214624
137pentose-phosphate shunt (GO:0006098)2.61107377
138ribonucleoprotein complex biogenesis (GO:0022613)2.60759728
139regulation of dendritic cell antigen processing and presentation (GO:0002604)2.59353557
140regulation of protein heterodimerization activity (GO:0043497)2.59132847
141cellular response to thyroid hormone stimulus (GO:0097067)2.58787222
142ncRNA 3-end processing (GO:0043628)2.58248267
143B cell receptor signaling pathway (GO:0050853)2.57761423
144base-excision repair (GO:0006284)2.56671472
145germinal center formation (GO:0002467)2.55441011
146regulation of antigen processing and presentation (GO:0002577)2.55109407
147macrophage differentiation (GO:0030225)2.54806098
148deoxyribose phosphate catabolic process (GO:0046386)2.54464306
149UV protection (GO:0009650)2.54271777
150positive T cell selection (GO:0043368)2.53979197
151megakaryocyte development (GO:0035855)2.53098860
152platelet dense granule organization (GO:0060155)2.52249598
153leukocyte aggregation (GO:0070486)2.51308553
154translation (GO:0006412)2.51216724
155alternative mRNA splicing, via spliceosome (GO:0000380)2.50433789
156respiratory burst (GO:0045730)2.50390891
157positive regulation of histone H3-K4 methylation (GO:0051571)2.48806587
158folic acid-containing compound biosynthetic process (GO:0009396)2.48593309
159maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.48522330
160regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.48265857
161regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.47570559
162termination of RNA polymerase II transcription (GO:0006369)2.47367888
163lipopolysaccharide-mediated signaling pathway (GO:0031663)2.46472986
164detection of biotic stimulus (GO:0009595)2.46337472
165establishment of integrated proviral latency (GO:0075713)2.46321553
166mismatch repair (GO:0006298)2.46273861
167response to thyroid hormone (GO:0097066)2.46099298
168negative T cell selection (GO:0043383)2.45979493
169T cell selection (GO:0045058)2.45896012
170B cell mediated immunity (GO:0019724)2.45888635
171mannose metabolic process (GO:0006013)2.45632401
172deoxyribonucleotide catabolic process (GO:0009264)2.45305427
173cellular response to interferon-beta (GO:0035458)2.44573233
174pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.43791698
175regulation of superoxide anion generation (GO:0032928)2.41479234
176thymic T cell selection (GO:0045061)2.39172137
177regulation of necrotic cell death (GO:0010939)2.38361750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.36758518
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.52333525
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.15251568
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.02300774
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.78865048
6MYC_22102868_ChIP-Seq_BL_Human2.76305576
7SCL_19346495_ChIP-Seq_HPC-7_Human2.75878093
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.71614770
9VDR_21846776_ChIP-Seq_THP-1_Human2.60095401
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.60009296
11SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.57782503
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.51520224
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.41377523
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.39688518
15TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.37801712
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.37312355
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.22488311
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.19272454
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.14886816
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.12692699
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.09108731
22* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.07350800
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.06340226
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.05359467
25EST1_17652178_ChIP-ChIP_JURKAT_Human2.04024723
26CIITA_25753668_ChIP-Seq_RAJI_Human2.00354249
27MYC_19030024_ChIP-ChIP_MESCs_Mouse1.99232928
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.97133229
29SPI1_23547873_ChIP-Seq_NB4_Human1.88025097
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.86205310
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84617611
32VDR_23849224_ChIP-Seq_CD4+_Human1.84149974
33SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.84078982
34ERG_20887958_ChIP-Seq_HPC-7_Mouse1.83222617
35XRN2_22483619_ChIP-Seq_HELA_Human1.82382776
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.82308849
37FOXP3_21729870_ChIP-Seq_TREG_Human1.82255929
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.81778305
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.80106879
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79526728
41VDR_24763502_ChIP-Seq_THP-1_Human1.76606263
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.76343446
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72498832
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.70192392
45MYB_26560356_Chip-Seq_TH2_Human1.68643080
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68491896
47SPI1_23127762_ChIP-Seq_K562_Human1.67294256
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.66972604
49KDM2B_26808549_Chip-Seq_DND41_Human1.66349736
50* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62672944
51GATA1_22025678_ChIP-Seq_K562_Human1.61808715
52BP1_19119308_ChIP-ChIP_Hs578T_Human1.60556721
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59682456
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.59471132
55MAF_26560356_Chip-Seq_TH1_Human1.55445666
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.55200014
57GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.52813014
58MYB_26560356_Chip-Seq_TH1_Human1.50800193
59NELFA_20434984_ChIP-Seq_ESCs_Mouse1.49307832
60* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49196689
61CREB1_15753290_ChIP-ChIP_HEK293T_Human1.48882458
62* RUNX1_22412390_ChIP-Seq_EML_Mouse1.48101422
63LXR_22292898_ChIP-Seq_THP-1_Human1.46115489
64UTX_26944678_Chip-Seq_JUKART_Human1.45903234
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45579194
66* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44958055
67DCP1A_22483619_ChIP-Seq_HELA_Human1.43094366
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42542488
69TCF7_22412390_ChIP-Seq_EML_Mouse1.38557320
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.37969317
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.37568339
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.37552925
73TTF2_22483619_ChIP-Seq_HELA_Human1.36781005
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34451151
75GABP_19822575_ChIP-Seq_HepG2_Human1.34248948
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31716807
77NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31349970
78NCOR1_26117541_ChIP-Seq_K562_Human1.30422806
79AR_21909140_ChIP-Seq_LNCAP_Human1.30237189
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30065871
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29694860
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29025808
83ZNF263_19887448_ChIP-Seq_K562_Human1.27675901
84* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27450828
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26418864
86FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25337506
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24051620
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22465353
89CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21934109
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21519479
91IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20985728
92MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20974154
93* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20825273
94ELK1_19687146_ChIP-ChIP_HELA_Human1.18499610
95GATA1_19941826_ChIP-Seq_K562_Human1.17919986
96HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16566393
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16271825
98ELF1_20517297_ChIP-Seq_JURKAT_Human1.15631214
99* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.14406753
100IRF8_27001747_Chip-Seq_BMDM_Mouse1.13002645
101RUNX_20019798_ChIP-Seq_JUKART_Human1.12657398
102* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11764106
103FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09215771
104THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07957578
105PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07843720
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05246511
107SRF_21415370_ChIP-Seq_HL-1_Mouse1.04973863
108* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04392808
109E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04362461
110* KDM5A_27292631_Chip-Seq_BREAST_Human1.04337435
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04137891
112* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03743505
113KDM2B_26808549_Chip-Seq_JURKAT_Human1.03124081
114E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02203108
115MAF_26560356_Chip-Seq_TH2_Human1.02153528
116RACK7_27058665_Chip-Seq_MCF-7_Human1.01606228
117P68_20966046_ChIP-Seq_HELA_Human1.01429681
118CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01348595
119* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98369404
120BCL6_27268052_Chip-Seq_Bcells_Human0.98141074
121PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98014141
122YY1_21170310_ChIP-Seq_MESCs_Mouse0.97436098
123GATA3_27048872_Chip-Seq_THYMUS_Human0.96748620
124CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96303308
125BCOR_27268052_Chip-Seq_Bcells_Human0.96155773
126MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.95917538
127CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95416119
128POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94678145
129GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93337874
130CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93016101
131TFEB_21752829_ChIP-Seq_HELA_Human0.92289935
132CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91951212
133TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91327919

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system5.32581371
2MP0001835_abnormal_antigen_presentation3.44032145
3MP0010094_abnormal_chromosome_stability3.21659282
4MP0003693_abnormal_embryo_hatching3.07852910
5MP0008057_abnormal_DNA_replication2.98759672
6MP0004808_abnormal_hematopoietic_stem2.76618728
7MP0005058_abnormal_lysosome_morphology2.70667277
8MP0000685_abnormal_immune_system2.50162644
9MP0003763_abnormal_thymus_physiology2.48463165
10MP0005174_abnormal_tail_pigmentation2.45591331
11MP0009785_altered_susceptibility_to2.43360927
12MP0000490_abnormal_crypts_of2.42733015
13MP0008007_abnormal_cellular_replicative2.42520501
14MP0001545_abnormal_hematopoietic_system2.42282893
15MP0005397_hematopoietic_system_phenotyp2.42282893
16MP0003077_abnormal_cell_cycle2.37507809
17MP0002398_abnormal_bone_marrow2.36556605
18MP0003111_abnormal_nucleus_morphology2.33828454
19MP0004957_abnormal_blastocyst_morpholog2.26846334
20MP0002166_altered_tumor_susceptibility2.26358408
21MP0005075_abnormal_melanosome_morpholog2.20952675
22MP0005025_abnormal_response_to2.20722388
23MP0001800_abnormal_humoral_immune2.18065323
24MP0002009_preneoplasia2.16216708
25MP0002420_abnormal_adaptive_immunity2.12284485
26MP0005671_abnormal_response_to2.11226454
27MP0001819_abnormal_immune_cell2.09274127
28MP0008058_abnormal_DNA_repair2.05928036
29MP0002452_abnormal_antigen_presenting2.04111641
30MP0000465_gastrointestinal_hemorrhage2.02067085
31MP0000689_abnormal_spleen_morphology1.99341661
32MP0003436_decreased_susceptibility_to1.99022228
33MP0002723_abnormal_immune_serum1.98182657
34MP0000716_abnormal_immune_system1.97489145
35MP0009278_abnormal_bone_marrow1.96202124
36MP0005464_abnormal_platelet_physiology1.95303848
37MP0002148_abnormal_hypersensitivity_rea1.93513236
38MP0005000_abnormal_immune_tolerance1.92052171
39MP0002722_abnormal_immune_system1.91536834
40MP0002419_abnormal_innate_immunity1.90253073
41MP0002006_tumorigenesis1.87479445
42MP0001853_heart_inflammation1.84126624
43MP0002429_abnormal_blood_cell1.83794278
44MP0000703_abnormal_thymus_morphology1.82742325
45MP0005451_abnormal_body_composition1.81950378
46MP0009333_abnormal_splenocyte_physiolog1.79420133
47MP0010352_gastrointestinal_tract_polyps1.73723558
48MP0010155_abnormal_intestine_physiology1.70898757
49MP0003866_abnormal_defecation1.70241407
50MP0002019_abnormal_tumor_incidence1.68040917
51MP0003806_abnormal_nucleotide_metabolis1.63252770
52MP0001790_abnormal_immune_system1.60851205
53MP0005387_immune_system_phenotype1.60851205
54MP0008260_abnormal_autophagy1.57852004
55MP0003303_peritoneal_inflammation1.57782344
56MP0001873_stomach_inflammation1.55110463
57MP0002405_respiratory_system_inflammati1.53631418
58MP0002095_abnormal_skin_pigmentation1.51643249
59MP0003300_gastrointestinal_ulcer1.47071917
60MP0004185_abnormal_adipocyte_glucose1.44690315
61MP0005076_abnormal_cell_differentiation1.38521056
62MP0003656_abnormal_erythrocyte_physiolo1.37953387
63MP0000858_altered_metastatic_potential1.33781501
64MP0003724_increased_susceptibility_to1.32706222
65MP0000350_abnormal_cell_proliferation1.29535705
66MP0010307_abnormal_tumor_latency1.27438552
67MP0001845_abnormal_inflammatory_respons1.26320876
68MP0006054_spinal_hemorrhage1.23900247
69MP0000313_abnormal_cell_death1.16970215
70MP0001851_eye_inflammation1.16887202
71MP0003075_altered_response_to1.09478731
72MP0008932_abnormal_embryonic_tissue1.06428819
73MP0002132_abnormal_respiratory_system1.06218361
74MP0008469_abnormal_protein_level1.01496484
75MP0009379_abnormal_foot_pigmentation1.00958720
76MP0004264_abnormal_extraembryonic_tissu1.00101936
77MP0009840_abnormal_foam_cell0.96834533
78MP0000015_abnormal_ear_pigmentation0.96579864
79MP0001986_abnormal_taste_sensitivity0.93411703
80MP0006082_CNS_inflammation0.93143823
81MP0002998_abnormal_bone_remodeling0.92617640
82MP0005666_abnormal_adipose_tissue0.91970685
83MP0009764_decreased_sensitivity_to0.88689155
84MP0000681_abnormal_thyroid_gland0.88440140
85MP0001730_embryonic_growth_arrest0.88426069
86MP0004947_skin_inflammation0.87481724
87MP0003183_abnormal_peptide_metabolism0.86088092
88MP0003786_premature_aging0.85848425
89MP0003943_abnormal_hepatobiliary_system0.85760550
90MP0000604_amyloidosis0.81228013
91MP0000477_abnormal_intestine_morphology0.77935269
92MP0003567_abnormal_fetal_cardiomyocyte0.77655083
93MP0003172_abnormal_lysosome_physiology0.77076452
94MP0000371_diluted_coat_color0.76735077
95MP0002080_prenatal_lethality0.76369091
96MP0008877_abnormal_DNA_methylation0.76322992
97MP0004782_abnormal_surfactant_physiolog0.74858027
98MP0005409_darkened_coat_color0.73920808
99MP0002075_abnormal_coat/hair_pigmentati0.73553404
100MP0009931_abnormal_skin_appearance0.72984295
101MP0005621_abnormal_cell_physiology0.72759319
102MP0001663_abnormal_digestive_system0.72199566
103MP0003448_altered_tumor_morphology0.71310453
104MP0005310_abnormal_salivary_gland0.70849426
105MP0003453_abnormal_keratinocyte_physiol0.68191837
106MP0008873_increased_physiological_sensi0.63054900
107MP0005501_abnormal_skin_physiology0.62873109
108MP0002796_impaired_skin_barrier0.62552261
109MP0005166_decreased_susceptibility_to0.62228515
110MP0001533_abnormal_skeleton_physiology0.61511742
111MP0000343_altered_response_to0.61361877
112MP0006036_abnormal_mitochondrial_physio0.59829937
113MP0001697_abnormal_embryo_size0.59002997
114MP0002933_joint_inflammation0.58548980
115MP0009763_increased_sensitivity_to0.57494355
116MP0005220_abnormal_exocrine_pancreas0.56847890
117MP0002877_abnormal_melanocyte_morpholog0.55717634
118MP0003828_pulmonary_edema0.55157057
119MP0006292_abnormal_olfactory_placode0.54643779
120MP0003191_abnormal_cellular_cholesterol0.53902564
121MP0000598_abnormal_liver_morphology0.52693390
122MP0002970_abnormal_white_adipose0.52592650
123MP0003984_embryonic_growth_retardation0.52229659
124MP0003186_abnormal_redox_activity0.52221010
125MP0003221_abnormal_cardiomyocyte_apopto0.52008579
126MP0009765_abnormal_xenobiotic_induced0.50424080
127MP0001672_abnormal_embryogenesis/_devel0.50308020

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)5.31307163
2Chronic otitis media (HP:0000389)5.07043885
3Elevated erythrocyte sedimentation rate (HP:0003565)4.94266009
4Abnormality of cells of the erythroid lineage (HP:0012130)4.59661457
5Abnormal number of erythroid precursors (HP:0012131)4.59655893
6IgM deficiency (HP:0002850)4.58001230
7Reticulocytopenia (HP:0001896)4.56453554
8Myositis (HP:0100614)4.13975705
9Aplastic anemia (HP:0001915)4.08229531
10Increased cerebral lipofuscin (HP:0011813)3.88387835
11Increased neuronal autofluorescent lipopigment (HP:0002074)3.61891834
12Acute lymphatic leukemia (HP:0006721)3.61884388
13Abnormality of T cell physiology (HP:0011840)3.52214890
14Recurrent bronchitis (HP:0002837)3.46764534
15Panhypogammaglobulinemia (HP:0003139)3.44325968
16Increased IgE level (HP:0003212)3.41716961
17Abnormality of liposaccharide metabolism (HP:0010968)3.39879701
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.39879701
19Abnormality of glycolipid metabolism (HP:0010969)3.39879701
20Recurrent abscess formation (HP:0002722)3.38091422
21Recurrent viral infections (HP:0004429)3.31945389
22Abnormality of macrophages (HP:0004311)3.15168517
23Meningitis (HP:0001287)3.13692726
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.11519047
25Acute myeloid leukemia (HP:0004808)3.10034350
26Recurrent bacterial skin infections (HP:0005406)3.07606357
27Cellulitis (HP:0100658)3.02419632
28B lymphocytopenia (HP:0010976)3.00565441
29Abnormality of B cell number (HP:0010975)3.00565441
30Thoracic kyphosis (HP:0002942)2.97147976
31Petechiae (HP:0000967)2.95901632
32Nasal polyposis (HP:0100582)2.94700393
33Autoimmune thrombocytopenia (HP:0001973)2.91983795
34Abnormality of T cells (HP:0002843)2.87186719
35Pallor (HP:0000980)2.80746102
36Colon cancer (HP:0003003)2.80020093
37Viral hepatitis (HP:0006562)2.76256420
3811 pairs of ribs (HP:0000878)2.73810839
39Poikiloderma (HP:0001029)2.66328748
40Dysostosis multiplex (HP:0000943)2.65685414
41Hepatosplenomegaly (HP:0001433)2.65403233
42Autoimmune hemolytic anemia (HP:0001890)2.63775251
43Lymphoma (HP:0002665)2.62118491
44Recurrent fungal infections (HP:0002841)2.60307697
45Macrocytic anemia (HP:0001972)2.60033707
46Mediastinal lymphadenopathy (HP:0100721)2.58303757
47Papilledema (HP:0001085)2.58282944
48Reduced antithrombin III activity (HP:0001976)2.56983094
49Interstitial pulmonary disease (HP:0006530)2.55763180
50Abnormality of the nasal mucosa (HP:0000433)2.55612335
51Abnormality of the fingertips (HP:0001211)2.53005955
52Gastrointestinal inflammation (HP:0004386)2.52745691
53Abnormality of the thoracic spine (HP:0100711)2.50465898
54Agammaglobulinemia (HP:0004432)2.48596229
55Urticaria (HP:0001025)2.48214735
56Myelodysplasia (HP:0002863)2.47647019
57Recurrent gram-negative bacterial infections (HP:0005420)2.44998699
58Oral leukoplakia (HP:0002745)2.44562085
59Abnormality of the prostate (HP:0008775)2.42140126
60Gingivitis (HP:0000230)2.40512256
61Hypertensive crisis (HP:0100735)2.39568753
62Thyroiditis (HP:0100646)2.39180247
63Inflammation of the large intestine (HP:0002037)2.37048408
64Chromsome breakage (HP:0040012)2.37021066
65Chronic sinusitis (HP:0011109)2.35417111
66Type I transferrin isoform profile (HP:0003642)2.32063355
67IgG deficiency (HP:0004315)2.30196241
68Prolonged bleeding time (HP:0003010)2.30192666
69Chronic obstructive pulmonary disease (HP:0006510)2.28791166
70Obstructive lung disease (HP:0006536)2.28791166
71Fatigue (HP:0012378)2.28473277
72Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.28463336
73Abnormality of DNA repair (HP:0003254)2.25785724
74Vacuolated lymphocytes (HP:0001922)2.25001978
75Ragged-red muscle fibers (HP:0003200)2.23294502
76Purpura (HP:0000979)2.22974826
77Abnormality of cells of the lymphoid lineage (HP:0012140)2.22528713
78Polygenic inheritance (HP:0010982)2.21318727
79Increased serum ferritin (HP:0003281)2.19877808
80Amaurosis fugax (HP:0100576)2.19553945
81Lymphopenia (HP:0001888)2.18514146
82Microvesicular hepatic steatosis (HP:0001414)2.18191190
83Spontaneous hematomas (HP:0007420)2.17883839
84Eczematoid dermatitis (HP:0000976)2.17478932
85Loss of speech (HP:0002371)2.16998514
86Abnormal platelet function (HP:0011869)2.15758680
87Impaired platelet aggregation (HP:0003540)2.15758680
88Hypoplasia of the thymus (HP:0000778)2.14331191
89Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.14195844
90Combined immunodeficiency (HP:0005387)2.13813038
91Sepsis (HP:0100806)2.13675240
92Recurrent skin infections (HP:0001581)2.13389391
93Birth length less than 3rd percentile (HP:0003561)2.12062523
94Granulocytopenia (HP:0001913)2.11545454
95Stomatitis (HP:0010280)2.11263059
96Agnosia (HP:0010524)2.10328166
97Severe combined immunodeficiency (HP:0004430)2.09281793
98Bone marrow hypocellularity (HP:0005528)2.05789805
99Pulmonary fibrosis (HP:0002206)2.02893995
100Hyperacusis (HP:0010780)2.02838361
101Abnormality of chromosome stability (HP:0003220)2.02385694
102Pancytopenia (HP:0001876)2.01926231
103Cutaneous melanoma (HP:0012056)2.01548177
104Orchitis (HP:0100796)2.01019903
105Gingival bleeding (HP:0000225)2.00788513
106Abnormal protein glycosylation (HP:0012346)2.00372008
107Abnormal glycosylation (HP:0012345)2.00372008
108Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00372008
109Abnormal protein N-linked glycosylation (HP:0012347)2.00372008
110Leukocytosis (HP:0001974)1.99880816
111Encephalitis (HP:0002383)1.98602070
112Colitis (HP:0002583)1.97726489
113Clubbing of toes (HP:0100760)1.96484420
114Chest pain (HP:0100749)1.95855737
115Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95759280
116Aplasia/Hypoplasia of the thymus (HP:0010515)1.94932815
117Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94736824
118Amyloidosis (HP:0011034)1.94652405
119Epistaxis (HP:0000421)1.94638388
120Arterial thrombosis (HP:0004420)1.94550474
121Abnormality of iron homeostasis (HP:0011031)1.93914876
122Multiple enchondromatosis (HP:0005701)1.93375602
123Entropion (HP:0000621)1.93347198
124Eosinophilia (HP:0001880)1.92268629
125Chronic mucocutaneous candidiasis (HP:0002728)1.91998380
126Recurrent cutaneous fungal infections (HP:0011370)1.91998380
127Severe visual impairment (HP:0001141)1.91902452
128Microretrognathia (HP:0000308)1.90812067
129Seborrheic dermatitis (HP:0001051)1.90751518
130Bronchitis (HP:0012387)1.90628857
131Abnormality of the columella (HP:0009929)1.90518921
132Osteomyelitis (HP:0002754)1.89990596
133Abnormality of the thymus (HP:0000777)1.89424514
134Albinism (HP:0001022)1.88689718
135Basal cell carcinoma (HP:0002671)1.86617606
136Abnormality of the peritoneum (HP:0002585)1.86144760
137Spinal cord lesions (HP:0100561)1.85631565
138Syringomyelia (HP:0003396)1.85631565
139Vasculitis (HP:0002633)1.84885181
140Centrally nucleated skeletal muscle fibers (HP:0003687)1.84685177
141Erythema (HP:0010783)1.84258459
142Skin rash (HP:0000988)1.83638367
143Pustule (HP:0200039)1.82827196
144Broad face (HP:0000283)1.81763813
145Hypergammaglobulinemia (HP:0010702)1.81693821
146Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.80604972
147Skin ulcer (HP:0200042)1.79632578
148Abnormality of the preputium (HP:0100587)1.79431616
149Progressive muscle weakness (HP:0003323)1.78970383
150Abnormality of the heme biosynthetic pathway (HP:0010472)1.78004258
151Abnormality of mucopolysaccharide metabolism (HP:0011020)1.77525716
152Abnormality of glycosaminoglycan metabolism (HP:0004371)1.77525716
153IgA deficiency (HP:0002720)1.77088243

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FLT33.89478975
2EEF2K3.72574069
3KIT3.33543741
4MAP4K12.98546984
5PRPF4B2.83932536
6WEE12.62219313
7CDC72.59738023
8CDK122.39703016
9STK162.31798441
10BTK2.31135986
11TEC2.29636308
12PIM22.24815072
13SMG12.23098969
14CSF1R2.17508172
15PKN22.12567281
16NME21.93233748
17MAP3K101.90117955
18MAP3K141.82582804
19SCYL21.81982724
20RPS6KB21.79632378
21IRAK41.77564668
22BRSK21.69012137
23MAP2K31.55165753
24TGFBR11.52919915
25CLK11.51009866
26PASK1.50579007
27MAP3K131.45734532
28ACVR1B1.40724959
29BUB11.38646136
30BLK1.36591453
31JAK31.36321230
32SYK1.36078338
33NEK21.34497748
34TBK11.31768243
35DYRK31.30519115
36VRK11.29056583
37ZAP701.25974624
38ATR1.24724615
39MAPKAPK31.24719380
40MKNK11.24269631
41LRRK21.21443002
42TNK21.19163874
43TYK21.18674739
44GRK61.18397947
45TESK21.14158453
46ICK1.13919581
47CDK41.12851885
48FES1.10962874
49EIF2AK31.10036589
50TLK11.10023986
51PIM11.08971572
52CDK71.07843669
53SRPK11.06202371
54VRK21.04672553
55TRIB31.04591603
56RPS6KA41.04354741
57TAOK31.03037532
58TSSK61.02968957
59TAOK21.02529328
60EIF2AK11.00720936
61CDK80.98500983
62CCNB10.98299352
63MAP3K10.97627510
64ITK0.94417273
65MATK0.94190272
66TNIK0.92646184
67STK100.86009864
68CDK190.84906300
69LCK0.84883908
70LYN0.82280667
71NLK0.81516410
72MKNK20.81022553
73BRD40.80274441
74CSK0.80231082
75TRPM70.76098083
76TXK0.73715136
77MAP3K60.72832479
78BRSK10.72829483
79JAK20.72701528
80MAPK40.72646653
81STK40.70358463
82PAK40.69646480
83AURKB0.68739108
84MAP3K110.67366765
85IRAK20.67092712
86IKBKE0.65845844
87MAP3K30.65718629
88CAMK1D0.63387363
89TAOK10.62942141
90RPS6KA60.62071164
91MTOR0.61841104
92HIPK20.61636755
93HCK0.61633295
94MAPK110.61363457
95ADRBK20.60953065
96IKBKB0.60936863
97DAPK10.60901545
98CDK90.59944656
99MAP3K80.59194665
100MAPKAPK50.58791818
101MAP2K20.58707771
102BMPR20.58290701
103MAP3K120.56450925
104PLK10.56012126
105ERN10.52471704
106RPS6KL10.51590397
107RPS6KC10.51590397
108YES10.51409281
109KDR0.49577116
110TTK0.49083271
111MARK20.48865172
112ILK0.48749866
113MAPK120.48263980
114PDPK10.46547450
115RAF10.44679562
116PDK10.44291728
117RIPK40.43404904
118CDK60.43110239
119CHEK20.42815371
120SIK10.41903929
121IRAK10.40574498
122MAPK30.40315329
123RET0.39753230
124RPS6KA20.38964007
125CHEK10.38249613
126JAK10.38150827
127IRAK30.37320808
128PTK60.36957067
129CDC42BPA0.36659323
130MAP3K50.36164631
131RPS6KA10.35934700
132CSNK2A20.35408421
133CDK20.33718085
134MAPKAPK20.33660449
135BCKDK0.33072427
136MAP2K60.32602764

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.80190441
2Mismatch repair_Homo sapiens_hsa034304.17908615
3Ribosome_Homo sapiens_hsa030103.75323112
4Base excision repair_Homo sapiens_hsa034103.31300368
5Homologous recombination_Homo sapiens_hsa034402.93726526
6Spliceosome_Homo sapiens_hsa030402.59038708
7Non-homologous end-joining_Homo sapiens_hsa034502.51278203
8Asthma_Homo sapiens_hsa053102.40486719
9Nucleotide excision repair_Homo sapiens_hsa034202.37730781
10Primary immunodeficiency_Homo sapiens_hsa053402.30264963
11Cell cycle_Homo sapiens_hsa041102.02567300
12Pyrimidine metabolism_Homo sapiens_hsa002401.97334851
13One carbon pool by folate_Homo sapiens_hsa006701.85860485
14Staphylococcus aureus infection_Homo sapiens_hsa051501.85339260
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82576670
16Graft-versus-host disease_Homo sapiens_hsa053321.81534718
17Autoimmune thyroid disease_Homo sapiens_hsa053201.77737617
18Antigen processing and presentation_Homo sapiens_hsa046121.72675857
19Proteasome_Homo sapiens_hsa030501.72328643
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72224680
21RNA transport_Homo sapiens_hsa030131.57143039
22Herpes simplex infection_Homo sapiens_hsa051681.56493161
23Fanconi anemia pathway_Homo sapiens_hsa034601.53670974
24Leishmaniasis_Homo sapiens_hsa051401.47719267
25B cell receptor signaling pathway_Homo sapiens_hsa046621.45016519
26RNA polymerase_Homo sapiens_hsa030201.43687470
27RNA degradation_Homo sapiens_hsa030181.39750749
28Lysosome_Homo sapiens_hsa041421.39251436
29Measles_Homo sapiens_hsa051621.36699966
30Type I diabetes mellitus_Homo sapiens_hsa049401.31345566
31N-Glycan biosynthesis_Homo sapiens_hsa005101.29433807
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29097274
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28627145
34Pentose phosphate pathway_Homo sapiens_hsa000301.26882563
35Acute myeloid leukemia_Homo sapiens_hsa052211.21794437
36Legionellosis_Homo sapiens_hsa051341.17277910
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.14133760
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12371295
39Hematopoietic cell lineage_Homo sapiens_hsa046401.11201931
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.11112543
41Protein export_Homo sapiens_hsa030601.05906528
42Bladder cancer_Homo sapiens_hsa052191.02583566
43Epstein-Barr virus infection_Homo sapiens_hsa051691.00401283
44p53 signaling pathway_Homo sapiens_hsa041150.99461366
45Notch signaling pathway_Homo sapiens_hsa043300.99275699
46VEGF signaling pathway_Homo sapiens_hsa043700.99103834
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98351436
48Intestinal immune network for IgA production_Homo sapiens_hsa046720.94899027
49Hepatitis B_Homo sapiens_hsa051610.93722538
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92713833
51Shigellosis_Homo sapiens_hsa051310.91664741
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91399772
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89692014
54Chronic myeloid leukemia_Homo sapiens_hsa052200.89649563
55Purine metabolism_Homo sapiens_hsa002300.89361393
56Osteoclast differentiation_Homo sapiens_hsa043800.89158809
57mRNA surveillance pathway_Homo sapiens_hsa030150.88746729
58Rheumatoid arthritis_Homo sapiens_hsa053230.87789310
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87406435
60Pertussis_Homo sapiens_hsa051330.87376531
61Thyroid cancer_Homo sapiens_hsa052160.86949622
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.85725464
63Influenza A_Homo sapiens_hsa051640.84806254
64Viral carcinogenesis_Homo sapiens_hsa052030.84023621
65Sulfur relay system_Homo sapiens_hsa041220.83064581
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81627843
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.80558252
68Phagosome_Homo sapiens_hsa041450.80262847
69mTOR signaling pathway_Homo sapiens_hsa041500.75686148
70Apoptosis_Homo sapiens_hsa042100.75509867
71Prolactin signaling pathway_Homo sapiens_hsa049170.75200599
72Allograft rejection_Homo sapiens_hsa053300.75164612
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74234894
74HTLV-I infection_Homo sapiens_hsa051660.74033265
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70736057
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70462736
77Toxoplasmosis_Homo sapiens_hsa051450.69068678
78Non-small cell lung cancer_Homo sapiens_hsa052230.68816692
79* Systemic lupus erythematosus_Homo sapiens_hsa053220.68055870
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.67191630
81Other glycan degradation_Homo sapiens_hsa005110.60881477
82Small cell lung cancer_Homo sapiens_hsa052220.60122805
83Renal cell carcinoma_Homo sapiens_hsa052110.57906700
84Amoebiasis_Homo sapiens_hsa051460.57499756
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56675393
86Platelet activation_Homo sapiens_hsa046110.55614919
87Colorectal cancer_Homo sapiens_hsa052100.55326577
88T cell receptor signaling pathway_Homo sapiens_hsa046600.53941077
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53902552
90Endometrial cancer_Homo sapiens_hsa052130.52632405
91Basal transcription factors_Homo sapiens_hsa030220.52055255
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52006293
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.51641768
94Tuberculosis_Homo sapiens_hsa051520.50981804
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.50621499
96Selenocompound metabolism_Homo sapiens_hsa004500.50281507
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50203941
98Inositol phosphate metabolism_Homo sapiens_hsa005620.49660299
99Pancreatic cancer_Homo sapiens_hsa052120.47829991
100Choline metabolism in cancer_Homo sapiens_hsa052310.47400488
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.46263100
102Fructose and mannose metabolism_Homo sapiens_hsa000510.45485217
103Folate biosynthesis_Homo sapiens_hsa007900.44899869
104Glioma_Homo sapiens_hsa052140.44779003
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.44505737
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42765060
107Renin-angiotensin system_Homo sapiens_hsa046140.42406101
108Viral myocarditis_Homo sapiens_hsa054160.42202523
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41112132
110Prostate cancer_Homo sapiens_hsa052150.40842825
111African trypanosomiasis_Homo sapiens_hsa051430.40820117
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.40663461
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40613721
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.40214078
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39390668
116Salmonella infection_Homo sapiens_hsa051320.38561411
117Galactose metabolism_Homo sapiens_hsa000520.37853688
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.35863916
119TNF signaling pathway_Homo sapiens_hsa046680.35803770
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35566238
121Chemokine signaling pathway_Homo sapiens_hsa040620.35376194
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35043955
123Malaria_Homo sapiens_hsa051440.33357303
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33273967
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32759242
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32245272
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30819321
128Hepatitis C_Homo sapiens_hsa051600.29351351
129MicroRNAs in cancer_Homo sapiens_hsa052060.29325731

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