H2AFY2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and may participate in stable X chromosome inactivation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)4.37973717
2negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.33301121
3pyrimidine nucleobase catabolic process (GO:0006208)4.27895840
4planar cell polarity pathway involved in neural tube closure (GO:0090179)4.11416877
5lateral sprouting from an epithelium (GO:0060601)4.00989691
6cell migration in hindbrain (GO:0021535)4.00551754
7paraxial mesoderm development (GO:0048339)4.00291285
8regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.98357805
9convergent extension (GO:0060026)3.84556101
10head development (GO:0060322)3.75482940
11negative regulation of mRNA processing (GO:0050686)3.68750837
12establishment or maintenance of monopolar cell polarity (GO:0061339)3.62872431
13establishment of monopolar cell polarity (GO:0061162)3.62872431
14establishment of apical/basal cell polarity (GO:0035089)3.62077192
15negative regulation of RNA splicing (GO:0033119)3.61715519
16peptidyl-arginine omega-N-methylation (GO:0035247)3.58107366
17spliceosomal tri-snRNP complex assembly (GO:0000244)3.56029392
18proline biosynthetic process (GO:0006561)3.53340603
19pre-miRNA processing (GO:0031054)3.48456334
20proximal/distal pattern formation (GO:0009954)3.39274932
21establishment of mitochondrion localization (GO:0051654)3.38524849
22somite development (GO:0061053)3.37399018
23positive regulation of mitochondrial fission (GO:0090141)3.35663317
24DNA damage response, detection of DNA damage (GO:0042769)3.33495184
25olfactory bulb development (GO:0021772)3.33088737
26histone arginine methylation (GO:0034969)3.31979478
27nucleosome disassembly (GO:0006337)3.30246951
28protein-DNA complex disassembly (GO:0032986)3.30246951
29axonal fasciculation (GO:0007413)3.27449974
30spinal cord association neuron differentiation (GO:0021527)3.25170416
31presynaptic membrane assembly (GO:0097105)3.25068878
32peptidyl-arginine methylation (GO:0018216)3.24870172
33peptidyl-arginine N-methylation (GO:0035246)3.24870172
34retinal ganglion cell axon guidance (GO:0031290)3.23451657
35limb bud formation (GO:0060174)3.21096990
36establishment of planar polarity (GO:0001736)3.19789459
37establishment of tissue polarity (GO:0007164)3.19789459
38neuron cell-cell adhesion (GO:0007158)3.19439100
39nonmotile primary cilium assembly (GO:0035058)3.18556406
40central nervous system projection neuron axonogenesis (GO:0021952)3.17999841
41postsynaptic membrane organization (GO:0001941)3.16542865
42cochlea morphogenesis (GO:0090103)3.13087677
43urogenital system development (GO:0001655)3.12307744
44calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.08088170
45protein localization to synapse (GO:0035418)3.06222121
46Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.03610537
47DNA strand renaturation (GO:0000733)3.00934659
48regulation of establishment of planar polarity (GO:0090175)3.00348769
49growth hormone secretion (GO:0030252)2.97915416
50negative regulation of axon extension involved in axon guidance (GO:0048843)2.97676348
51embryonic hindlimb morphogenesis (GO:0035116)2.97285047
52neuron fate commitment (GO:0048663)2.96701713
53hindlimb morphogenesis (GO:0035137)2.93639940
54nucleobase catabolic process (GO:0046113)2.90597109
55regulation of development, heterochronic (GO:0040034)2.90360255
56presynaptic membrane organization (GO:0097090)2.89895812
57oxidative demethylation (GO:0070989)2.89301004
58embryonic foregut morphogenesis (GO:0048617)2.89198657
59negative regulation of mRNA metabolic process (GO:1903312)2.88849934
60outer ear morphogenesis (GO:0042473)2.87232363
61negative regulation of catenin import into nucleus (GO:0035414)2.85092070
62dorsal/ventral axis specification (GO:0009950)2.83858662
63negative regulation of axon guidance (GO:1902668)2.83276434
64regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.83005908
65dendritic spine morphogenesis (GO:0060997)2.82305470
66DNA demethylation (GO:0080111)2.79859217
67sequestering of actin monomers (GO:0042989)2.78906480
68polarized epithelial cell differentiation (GO:0030859)2.78876729
69post-anal tail morphogenesis (GO:0036342)2.78801186
70positive regulation of gastrulation (GO:2000543)2.78177501
71neuronal stem cell maintenance (GO:0097150)2.78019483
72replication fork processing (GO:0031297)2.77923230
73DNA double-strand break processing (GO:0000729)2.77770818
74embryonic camera-type eye development (GO:0031076)2.77288389
75gastrulation with mouth forming second (GO:0001702)2.77020216
76cranial nerve morphogenesis (GO:0021602)2.76977663
77non-canonical Wnt signaling pathway (GO:0035567)2.75402971
78short-term memory (GO:0007614)2.75148601
79ganglion development (GO:0061548)2.74870138
80negative regulation of chondrocyte differentiation (GO:0032331)2.74788085
81face development (GO:0060324)2.74219205
82regulation of DNA damage checkpoint (GO:2000001)2.74045560
83negative regulation of microtubule polymerization (GO:0031115)2.73389434
84establishment of nucleus localization (GO:0040023)2.72070784
85L-serine metabolic process (GO:0006563)2.70991501
86primitive streak formation (GO:0090009)2.70968315
87synapse assembly (GO:0007416)2.68287098
88hippocampus development (GO:0021766)2.67478759
89negative regulation of JAK-STAT cascade (GO:0046426)2.67303015
90spinal cord development (GO:0021510)2.65878764
91regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.64880014
92regulation of NFAT protein import into nucleus (GO:0051532)2.64860660
93behavioral response to nicotine (GO:0035095)2.64419096
94body morphogenesis (GO:0010171)2.64070686
95RNA localization (GO:0006403)2.63431237
96G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.63398961
97cholesterol biosynthetic process (GO:0006695)2.62124589
98negative regulation of glial cell differentiation (GO:0045686)2.62010388
99ectodermal placode formation (GO:0060788)2.59926890
100intraciliary transport (GO:0042073)2.59115101
101regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.58161530
102hippo signaling (GO:0035329)2.57910595
103regulation of sister chromatid cohesion (GO:0007063)2.57705769
104viral mRNA export from host cell nucleus (GO:0046784)2.57298280
105regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.56490633
106neuron fate determination (GO:0048664)2.54479595
107mRNA splice site selection (GO:0006376)2.54274287
108neural tube closure (GO:0001843)2.50658348
109vocalization behavior (GO:0071625)2.49946570
110negative regulation of oligodendrocyte differentiation (GO:0048715)2.49786544
111dopaminergic neuron differentiation (GO:0071542)2.49556705
112DNA unwinding involved in DNA replication (GO:0006268)2.49308144
113layer formation in cerebral cortex (GO:0021819)2.48838934
114neuron recognition (GO:0008038)2.48535020
115ephrin receptor signaling pathway (GO:0048013)2.48419763
116tube closure (GO:0060606)2.47231567
117neuron projection extension involved in neuron projection guidance (GO:1902284)2.46901673
118axon extension involved in axon guidance (GO:0048846)2.46901673
119termination of RNA polymerase II transcription (GO:0006369)2.45369344
120mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.44223967
121intracellular estrogen receptor signaling pathway (GO:0030520)2.42246999
122negative regulation of cell cycle arrest (GO:0071157)2.39386842
123regulation of RNA export from nucleus (GO:0046831)2.38854091
124negative regulation of cartilage development (GO:0061037)2.38629485
125substrate-independent telencephalic tangential migration (GO:0021826)2.38625797
126substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.38625797
127positive regulation of synapse assembly (GO:0051965)2.38599785
128regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.38056776
129DNA topological change (GO:0006265)2.37260080
130axon extension (GO:0048675)2.36873955
131cell proliferation in forebrain (GO:0021846)2.36749084
132chromatin remodeling at centromere (GO:0031055)2.35701725
133sympathetic nervous system development (GO:0048485)2.34938468
134transcription from mitochondrial promoter (GO:0006390)2.34366029
135cerebral cortex radially oriented cell migration (GO:0021799)2.33930938
136DNA integration (GO:0015074)2.33793717
137forebrain neuron differentiation (GO:0021879)2.33693271
138regulation of timing of cell differentiation (GO:0048505)2.33362549
139glial cell migration (GO:0008347)2.31998624
140glandular epithelial cell development (GO:0002068)2.31716384
141hindbrain development (GO:0030902)2.31520357
142generation of neurons (GO:0048699)2.30592804
143limb development (GO:0060173)2.30083252
144appendage development (GO:0048736)2.30083252
145DNA ligation (GO:0006266)2.29251900
146mitochondrion transport along microtubule (GO:0047497)2.28945243
147establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.28945243
148cell differentiation in spinal cord (GO:0021515)2.28806050
149ATP-dependent chromatin remodeling (GO:0043044)2.28596741
150regulation of oligodendrocyte differentiation (GO:0048713)2.28174098
151sterol biosynthetic process (GO:0016126)2.25974984
152regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.22162987
153dorsal/ventral neural tube patterning (GO:0021904)2.21811559
154RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.19345101
155tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.19345101
156neurotransmitter-gated ion channel clustering (GO:0072578)2.18482658
157lung-associated mesenchyme development (GO:0060484)2.16542805
158protein polyglutamylation (GO:0018095)2.15577826
159neuron migration (GO:0001764)2.13720822
160gamma-aminobutyric acid transport (GO:0015812)2.11998332
161apical protein localization (GO:0045176)2.09774370
162lens morphogenesis in camera-type eye (GO:0002089)2.09351199

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.87747721
2TP63_19390658_ChIP-ChIP_HaCaT_Human2.94534004
3ZFP281_18757296_ChIP-ChIP_E14_Mouse2.77811718
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.67755764
5E2F7_22180533_ChIP-Seq_HELA_Human2.64013622
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.42287726
7EZH2_22144423_ChIP-Seq_EOC_Human2.42247219
8SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.34261438
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.33967841
10IGF1R_20145208_ChIP-Seq_DFB_Human2.25260059
11HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.22763680
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.19234497
13SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.13486031
14* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.12490870
15ZFP281_27345836_Chip-Seq_ESCs_Mouse2.09263324
16TP53_20018659_ChIP-ChIP_R1E_Mouse2.07138339
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06277389
18* SOX2_18555785_ChIP-Seq_MESCs_Mouse2.02766730
19EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.02694738
20* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.01263286
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98317250
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.93969408
23CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.93399989
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.90060360
25* RING1B_27294783_Chip-Seq_NPCs_Mouse1.89865740
26OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.88439597
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.85559348
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.85537312
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85380055
30* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.84327233
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.82923345
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.82775184
33KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.77651179
34NANOG_21062744_ChIP-ChIP_HESCs_Human1.73406504
35* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.71684230
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.66664450
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66440813
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.64629447
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60006660
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59645293
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56838391
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.56015172
43TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.54135224
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.53600229
45KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.53600229
46KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.53600229
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53131717
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.51076625
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.49631821
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49551844
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49547039
52CREB1_15753290_ChIP-ChIP_HEK293T_Human1.48107837
53RING1B_27294783_Chip-Seq_ESCs_Mouse1.47881138
54TCF3_18692474_ChIP-Seq_MESCs_Mouse1.47464789
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.47369232
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.46444544
57DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.46274587
58* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.45905846
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44642776
60RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44642776
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.44437964
62POU5F1_16518401_ChIP-PET_MESCs_Mouse1.43066338
63RNF2_27304074_Chip-Seq_NSC_Mouse1.41221904
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40866611
65IRF1_19129219_ChIP-ChIP_H3396_Human1.39199206
66* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38918757
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38426232
68* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35962250
69SOX2_16153702_ChIP-ChIP_HESCs_Human1.35229855
70* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.34322732
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.33456809
72* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31449368
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30390656
74GABP_17652178_ChIP-ChIP_JURKAT_Human1.30220208
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.30001698
76NANOG_16153702_ChIP-ChIP_HESCs_Human1.29611246
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29453002
78* KDM2B_26808549_Chip-Seq_K562_Human1.29072994
79REST_21632747_ChIP-Seq_MESCs_Mouse1.28641452
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28474416
81GATA1_26923725_Chip-Seq_HPCs_Mouse1.28370510
82SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28186897
83GBX2_23144817_ChIP-Seq_PC3_Human1.27764407
84TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25515881
85SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.24663844
86* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.23964324
87ETS1_20019798_ChIP-Seq_JURKAT_Human1.23678563
88SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23188842
89GABP_19822575_ChIP-Seq_HepG2_Human1.22563141
90* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.22078904
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20861259
92TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.20643860
93EZH2_27294783_Chip-Seq_ESCs_Mouse1.19980811
94CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19780192
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19096024
96FUS_26573619_Chip-Seq_HEK293_Human1.18484791
97TAF15_26573619_Chip-Seq_HEK293_Human1.18101525
98LXR_22292898_ChIP-Seq_THP-1_Human1.17762930
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17756402
100XRN2_22483619_ChIP-Seq_HELA_Human1.17319392
101FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.16482392
102JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16298563
103E2F4_17652178_ChIP-ChIP_JURKAT_Human1.16033356
104MYC_18940864_ChIP-ChIP_HL60_Human1.15818982
105PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15010568
106EST1_17652178_ChIP-ChIP_JURKAT_Human1.14653065
107ISL1_27105846_Chip-Seq_CPCs_Mouse1.14609720
108ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14534366
109FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14516271
110SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14262181
111* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.14233674
112CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14215693
113EWS_26573619_Chip-Seq_HEK293_Human1.14205136
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11905959
115MYC_19030024_ChIP-ChIP_MESCs_Mouse1.11610084
116SOX2_18692474_ChIP-Seq_MESCs_Mouse1.11222770
117MYC_22102868_ChIP-Seq_BL_Human1.10404422
118ZNF274_21170338_ChIP-Seq_K562_Hela1.08551220
119SOX3_22085726_ChIP-Seq_NPCs_Mouse1.08518895
120SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.08486763
121* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.07582032
122SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.06771193
123KDM2B_26808549_Chip-Seq_DND41_Human1.06764519
124TTF2_22483619_ChIP-Seq_HELA_Human1.06568895
125MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06111786
126ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05254294
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04821353
128POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04082982
129CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02796999
130EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.02229618
131PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01250663
132POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00473324
133CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99720601
134SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98977143
135SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95884609
136SOX9_26525672_Chip-Seq_HEART_Mouse0.95488466
137MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93231935
138PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92105928
139SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.90168450

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.50984901
2MP0003122_maternal_imprinting3.73029490
3MP0000537_abnormal_urethra_morphology3.03126659
4MP0009053_abnormal_anal_canal2.69198267
5MP0003283_abnormal_digestive_organ2.55997227
6MP0003121_genomic_imprinting2.52975423
7MP0003890_abnormal_embryonic-extraembry2.50033869
8MP0003119_abnormal_digestive_system2.36471010
9MP0002653_abnormal_ependyma_morphology2.35583589
10MP0003385_abnormal_body_wall2.22452098
11MP0002249_abnormal_larynx_morphology2.20766111
12MP0000778_abnormal_nervous_system2.18912884
13MP0000049_abnormal_middle_ear2.10154676
14MP0002282_abnormal_trachea_morphology2.09631017
15MP0002822_catalepsy2.06703432
16MP0003942_abnormal_urinary_system2.01986198
17MP0004133_heterotaxia1.91613537
18MP0004233_abnormal_muscle_weight1.90995442
19MP0002932_abnormal_joint_morphology1.80409532
20MP0003123_paternal_imprinting1.77653882
21MP0008995_early_reproductive_senescence1.74759052
22MP0008789_abnormal_olfactory_epithelium1.73478595
23MP0000566_synostosis1.66263568
24MP0003755_abnormal_palate_morphology1.65196909
25MP0002938_white_spotting1.60936448
26MP0000534_abnormal_ureter_morphology1.60126120
27MP0001293_anophthalmia1.59628786
28MP0003861_abnormal_nervous_system1.56998346
29MP0003935_abnormal_craniofacial_develop1.55319438
30MP0003315_abnormal_perineum_morphology1.54883999
31MP0004270_analgesia1.52785311
32MP0002084_abnormal_developmental_patter1.52161585
33MP0005645_abnormal_hypothalamus_physiol1.51160763
34MP0002116_abnormal_craniofacial_bone1.50971768
35MP0003115_abnormal_respiratory_system1.50221318
36MP0005076_abnormal_cell_differentiation1.48616741
37MP0008057_abnormal_DNA_replication1.47458594
38MP0003937_abnormal_limbs/digits/tail_de1.46080046
39MP0005248_abnormal_Harderian_gland1.44248412
40MP0002085_abnormal_embryonic_tissue1.43766297
41MP0009250_abnormal_appendicular_skeleto1.43578444
42MP0000428_abnormal_craniofacial_morphol1.39415270
43MP0006276_abnormal_autonomic_nervous1.39265067
44MP0004197_abnormal_fetal_growth/weight/1.37463596
45MP0005394_taste/olfaction_phenotype1.35902545
46MP0005499_abnormal_olfactory_system1.35902545
47MP0002697_abnormal_eye_size1.34142137
48MP0002751_abnormal_autonomic_nervous1.32670163
49MP0003693_abnormal_embryo_hatching1.30019129
50MP0002184_abnormal_innervation1.27672351
51MP0003787_abnormal_imprinting1.27096334
52MP0000462_abnormal_digestive_system1.25901477
53MP0006072_abnormal_retinal_apoptosis1.25461201
54MP0002234_abnormal_pharynx_morphology1.25380017
55MP0002233_abnormal_nose_morphology1.25264344
56MP0003938_abnormal_ear_development1.23405452
57MP0008932_abnormal_embryonic_tissue1.22422873
58MP0003136_yellow_coat_color1.21832236
59MP0005187_abnormal_penis_morphology1.20084322
60MP0002111_abnormal_tail_morphology1.19023461
61MP0000631_abnormal_neuroendocrine_gland1.18397851
62MP0003567_abnormal_fetal_cardiomyocyte1.16873943
63MP0010094_abnormal_chromosome_stability1.15896276
64MP0000026_abnormal_inner_ear1.15619727
65MP0001286_abnormal_eye_development1.15304267
66MP0002114_abnormal_axial_skeleton1.14734148
67MP0002557_abnormal_social/conspecific_i1.14422182
68MP0001188_hyperpigmentation1.14084117
69MP0000955_abnormal_spinal_cord1.12960542
70MP0006292_abnormal_olfactory_placode1.12575412
71MP0001697_abnormal_embryo_size1.11145764
72MP0002081_perinatal_lethality1.10422718
73MP0002752_abnormal_somatic_nervous1.10046129
74MP0005367_renal/urinary_system_phenotyp1.09044347
75MP0000516_abnormal_urinary_system1.09044347
76MP0001340_abnormal_eyelid_morphology1.06301348
77MP0000432_abnormal_head_morphology1.05401648
78MP0002882_abnormal_neuron_morphology1.04973696
79MP0002102_abnormal_ear_morphology1.03422857
80MP0002152_abnormal_brain_morphology1.02980275
81MP0002734_abnormal_mechanical_nocicepti1.02957055
82MP0003880_abnormal_central_pattern1.02389092
83MP0005646_abnormal_pituitary_gland1.02026510
84MP0009278_abnormal_bone_marrow1.01979303
85MP0003111_abnormal_nucleus_morphology1.01491371
86MP0001984_abnormal_olfaction1.00899796
87MP0003635_abnormal_synaptic_transmissio1.00697276
88MP0002177_abnormal_outer_ear0.98379154
89MP0002736_abnormal_nociception_after0.98141992
90MP0005253_abnormal_eye_physiology0.98023286
91MP0004859_abnormal_synaptic_plasticity0.97889882
92MP0002092_abnormal_eye_morphology0.97465078
93MP0000762_abnormal_tongue_morphology0.94857629
94MP0004811_abnormal_neuron_physiology0.94535118
95MP0005380_embryogenesis_phenotype0.94125251
96MP0001672_abnormal_embryogenesis/_devel0.94125251
97MP0002638_abnormal_pupillary_reflex0.93195528
98MP0001270_distended_abdomen0.92708247
99MP0000733_abnormal_muscle_development0.92245558
100MP0002572_abnormal_emotion/affect_behav0.92082316
101MP0005171_absent_coat_pigmentation0.90557898
102MP0004142_abnormal_muscle_tone0.90206601
103MP0001299_abnormal_eye_distance/0.90003545
104MP0003077_abnormal_cell_cycle0.87800874
105MP0001730_embryonic_growth_arrest0.87252288
106MP0000350_abnormal_cell_proliferation0.86478744
107MP0002109_abnormal_limb_morphology0.86396067
108MP0009703_decreased_birth_body0.85706951
109MP0001486_abnormal_startle_reflex0.85653529
110MP0002089_abnormal_postnatal_growth/wei0.85316785
111MP0005508_abnormal_skeleton_morphology0.83996191
112MP0004134_abnormal_chest_morphology0.81476711
113MP0005195_abnormal_posterior_eye0.81277625
114MP0002063_abnormal_learning/memory/cond0.81115171
115MP0003137_abnormal_impulse_conducting0.80946907
116MP0008058_abnormal_DNA_repair0.80879908
117MP0005423_abnormal_somatic_nervous0.80428089
118MP0001529_abnormal_vocalization0.80115970
119MP0001849_ear_inflammation0.79864787
120MP0001968_abnormal_touch/_nociception0.79767177
121MP0002086_abnormal_extraembryonic_tissu0.78847754
122MP0000678_abnormal_parathyroid_gland0.78712287
123MP0005391_vision/eye_phenotype0.78637493
124MP0000647_abnormal_sebaceous_gland0.76726092
125MP0009745_abnormal_behavioral_response0.73372035
126MP0001346_abnormal_lacrimal_gland0.72251454

Predicted human phenotypes

RankGene SetZ-score
1Renal duplication (HP:0000075)4.15107210
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.74965299
3Short 4th metacarpal (HP:0010044)3.74965299
4Cortical dysplasia (HP:0002539)3.36925963
5Coronal craniosynostosis (HP:0004440)3.33113180
6Abnormality of the 4th metacarpal (HP:0010012)3.05029560
7Abnormality of the labia minora (HP:0012880)2.93663021
8Hyperacusis (HP:0010780)2.93092420
9Abnormality of the aortic arch (HP:0012303)2.75748073
10Rib fusion (HP:0000902)2.71744576
11Facial hemangioma (HP:0000329)2.70386991
12Hypoplastic pelvis (HP:0008839)2.67286332
13Failure to thrive in infancy (HP:0001531)2.67204649
14Retinal dysplasia (HP:0007973)2.60034111
15Septo-optic dysplasia (HP:0100842)2.56831691
16Turricephaly (HP:0000262)2.54833468
17Gait imbalance (HP:0002141)2.51320990
18Annular pancreas (HP:0001734)2.50454041
19Lissencephaly (HP:0001339)2.46453180
20Elfin facies (HP:0004428)2.46218366
21Intestinal atresia (HP:0011100)2.43941206
22Short 5th finger (HP:0009237)2.43897789
23Anteriorly placed anus (HP:0001545)2.43694807
24Renovascular hypertension (HP:0100817)2.43158330
25Broad alveolar ridges (HP:0000187)2.42123461
26Concave nail (HP:0001598)2.41735867
27Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.40556607
28Overriding aorta (HP:0002623)2.36507586
29Abnormal number of incisors (HP:0011064)2.34599050
30Hepatoblastoma (HP:0002884)2.32789549
31High anterior hairline (HP:0009890)2.32251166
32Vaginal atresia (HP:0000148)2.32148944
33Congenital primary aphakia (HP:0007707)2.31826560
34Hypoplasia of the brainstem (HP:0002365)2.30597679
35Aplasia/Hypoplasia of the brainstem (HP:0007362)2.30597679
36Astrocytoma (HP:0009592)2.29828483
37Abnormality of the astrocytes (HP:0100707)2.29828483
38Vitreoretinal degeneration (HP:0000655)2.28073654
39Anophthalmia (HP:0000528)2.27983060
40Nephrogenic diabetes insipidus (HP:0009806)2.27318226
41Patellar aplasia (HP:0006443)2.25221482
42Broad toe (HP:0001837)2.24754724
43Oligodactyly (HP:0012165)2.24722958
44Narrow nasal bridge (HP:0000446)2.24034874
45Genital tract atresia (HP:0001827)2.22137227
46Insomnia (HP:0100785)2.21022410
47Increased number of teeth (HP:0011069)2.19227010
48Aplasia/Hypoplasia of the patella (HP:0006498)2.18039278
49Midline defect of the nose (HP:0004122)2.16678158
50Medial flaring of the eyebrow (HP:0010747)2.12995163
51Abnormality of the intervertebral disk (HP:0005108)2.12730249
52Optic nerve hypoplasia (HP:0000609)2.12684679
53Broad thumb (HP:0011304)2.11938314
54Shallow orbits (HP:0000586)2.11364109
55Abnormality of the diencephalon (HP:0010662)2.10581726
56Increased nuchal translucency (HP:0010880)2.10014360
57Bifid tongue (HP:0010297)2.09291678
58Hemivertebrae (HP:0002937)2.08176442
59Flat cornea (HP:0007720)2.07315170
60Myelomeningocele (HP:0002475)2.05436845
61Ependymoma (HP:0002888)2.05014171
62Sex reversal (HP:0012245)2.04398987
63Abnormal sex determination (HP:0012244)2.04398987
64Sacral dimple (HP:0000960)2.03923871
65Renal dysplasia (HP:0000110)2.03439389
66Morphological abnormality of the middle ear (HP:0008609)2.02020586
67Spina bifida occulta (HP:0003298)1.99326506
68Trigonocephaly (HP:0000243)1.97642731
69Cutaneous finger syndactyly (HP:0010554)1.97402343
70Rectal fistula (HP:0100590)1.97176256
71Rectovaginal fistula (HP:0000143)1.97176256
72Alacrima (HP:0000522)1.96935801
73Pointed chin (HP:0000307)1.95963409
74Drooling (HP:0002307)1.95582401
75Occipital encephalocele (HP:0002085)1.94206867
76Oligodactyly (hands) (HP:0001180)1.93833275
77Shawl scrotum (HP:0000049)1.93545757
78Small hand (HP:0200055)1.92342685
79Selective tooth agenesis (HP:0001592)1.92135207
80Short humerus (HP:0005792)1.91699087
81Tented upper lip vermilion (HP:0010804)1.90627520
82Hyperglycinemia (HP:0002154)1.89205185
83Broad foot (HP:0001769)1.88832866
84Aplasia/hypoplasia of the humerus (HP:0006507)1.88770886
85Choanal stenosis (HP:0000452)1.88192405
86Megalocornea (HP:0000485)1.87567054
87Split foot (HP:0001839)1.85600008
88Maternal diabetes (HP:0009800)1.85329292
89Bilateral microphthalmos (HP:0007633)1.84974552
90Abnormality of abdominal situs (HP:0011620)1.84961660
91Abdominal situs inversus (HP:0003363)1.84961660
92Patellar dislocation (HP:0002999)1.84613461
93Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84340361
94Short middle phalanx of the 5th finger (HP:0004220)1.84189396
95Preaxial hand polydactyly (HP:0001177)1.80855371
96Micropenis (HP:0000054)1.80410948
97Postaxial hand polydactyly (HP:0001162)1.80211072
98Aplasia/Hypoplasia of the sternum (HP:0006714)1.80152319
99Meningocele (HP:0002435)1.80010999
100Preaxial foot polydactyly (HP:0001841)1.79671117
101Neoplasm of the heart (HP:0100544)1.79613012
102Broad phalanges of the hand (HP:0009768)1.79292540
103Renal hypoplasia (HP:0000089)1.78914782
104Vesicoureteral reflux (HP:0000076)1.78576255
105Glioma (HP:0009733)1.77920837
106Ectopic anus (HP:0004397)1.77891688
107Cutaneous syndactyly (HP:0012725)1.77399402
108Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77075897
109Absent epiphyses (HP:0010577)1.77075897
110Amblyopia (HP:0000646)1.76588926
111Abnormality of the lower motor neuron (HP:0002366)1.75148703
112Humeroradial synostosis (HP:0003041)1.74959390
113Synostosis involving the elbow (HP:0003938)1.74959390
114Poor coordination (HP:0002370)1.74955012
115Type II lissencephaly (HP:0007260)1.74930867
116Medulloblastoma (HP:0002885)1.74297145
117Abnormality of the phalanges of the hallux (HP:0010057)1.74145117
118Optic nerve coloboma (HP:0000588)1.73417489
119Broad distal phalanx of finger (HP:0009836)1.72945058
120Abnormal lung lobation (HP:0002101)1.72490187
121Bowel diverticulosis (HP:0005222)1.72186579
122Esophageal atresia (HP:0002032)1.72071888
123Broad finger (HP:0001500)1.71291871
124Abnormality of the proximal phalanges of the hand (HP:0009834)1.71266607
125Pachygyria (HP:0001302)1.70619155
126Abnormality of the pubic bones (HP:0003172)1.70401312
127Vertebral fusion (HP:0002948)1.70220576
128Specific learning disability (HP:0001328)1.70212701
129Nephronophthisis (HP:0000090)1.69218888
130Pendular nystagmus (HP:0012043)1.69053373
131Intestinal fistula (HP:0100819)1.68243249
132Short philtrum (HP:0000322)1.68180017
133True hermaphroditism (HP:0010459)1.68080817
134Absent septum pellucidum (HP:0001331)1.67647629
135Hypoplastic labia majora (HP:0000059)1.67208888
136Abnormality of the metopic suture (HP:0005556)1.67027218
137Excessive salivation (HP:0003781)1.66796568
138Deviation of the hallux (HP:0010051)1.65893963
139Aplasia involving forearm bones (HP:0009822)1.65832525
140Absent forearm bone (HP:0003953)1.65832525
141Cerebellar dysplasia (HP:0007033)1.65597346
142Volvulus (HP:0002580)1.65417926
143Myokymia (HP:0002411)1.65329334
144Polyphagia (HP:0002591)1.65084544
145Shoulder girdle muscle weakness (HP:0003547)1.64657142
146Absent radius (HP:0003974)1.64501690
147Heterotopia (HP:0002282)1.64170649
148Hypoplastic female external genitalia (HP:0012815)1.63517077
149Labial hypoplasia (HP:0000066)1.63323141
150Congenital glaucoma (HP:0001087)1.62387278
151Postaxial foot polydactyly (HP:0001830)1.62232112
152Anencephaly (HP:0002323)1.62026057
153Short tibia (HP:0005736)1.61610994
154Orthostatic hypotension (HP:0001278)1.61415726
155Decreased testicular size (HP:0008734)1.61157183
156Bicornuate uterus (HP:0000813)1.61060139
157Colon cancer (HP:0003003)1.61007856
158Vaginal fistula (HP:0004320)1.60805216
159Broad hallux (HP:0010055)1.60744322
160Sleep apnea (HP:0010535)1.60439984
161Bladder diverticulum (HP:0000015)1.59461034
162Wrist flexion contracture (HP:0001239)1.59362182
163Irregular epiphyses (HP:0010582)1.59261315
164Scrotal hypoplasia (HP:0000046)1.58499408
165Abnormality of the parathyroid morphology (HP:0011766)1.56121853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK3.85297967
2EPHB23.72146687
3MARK13.23847070
4UHMK13.19110671
5DDR23.04808080
6MAP3K103.02529011
7TRIM282.74944214
8KSR12.66424412
9MAP2K72.59237351
10CASK2.51673846
11DYRK22.48589725
12PDGFRA2.25403525
13EPHA42.23726488
14LATS22.23620254
15MAP4K22.17364997
16TYRO32.15872558
17ERBB32.13413958
18WNK31.87746027
19SIK31.82079738
20DYRK31.73803320
21BCR1.72307155
22BCKDK1.67013948
23MAPK151.65288729
24CDK191.55813165
25CDC71.49217112
26PAK61.48195392
27PLK41.47025472
28DYRK1B1.46039106
29MAP3K61.41894067
30ERBB21.34882763
31PHKG11.33284654
32PHKG21.33284654
33NTRK21.27468477
34RPS6KA41.26356454
35YES11.15460625
36MKNK11.13421601
37MINK11.09433217
38FGFR11.06856439
39LIMK11.05343744
40IRAK21.04920215
41PAK31.04571897
42CHEK21.04311610
43ATR1.04231669
44CDK71.03981427
45PASK1.02488283
46DAPK11.02004640
47CDK181.01981139
48NEK10.99145716
49MAP2K40.98106747
50BRD40.96838379
51FGFR20.94176492
52TTK0.94051399
53MAP3K110.92988148
54EPHA30.92251941
55BMX0.91536710
56TESK20.91523475
57CDK150.91270587
58LATS10.90755871
59MTOR0.90251396
60MAPK130.90084817
61CDK140.89213207
62PLK20.89172681
63CDK120.87262022
64MAP3K90.86402551
65NEK20.86231364
66STK38L0.85423960
67PRKCG0.83584215
68CDK11A0.83009099
69WEE10.81629942
70PAK40.80392830
71SRPK10.79338794
72MATK0.78504568
73PLK10.76515218
74SIK20.74694669
75CDC42BPA0.74487931
76TGFBR10.74305877
77TSSK60.73545534
78PAK20.71574818
79PNCK0.71402454
80FGR0.70912196
81CSNK1G30.70121712
82TRIB30.69443466
83ZAK0.69111009
84TESK10.67327818
85AURKA0.65934998
86BUB10.64269794
87SCYL20.64212182
88CSNK1G10.63922974
89CDK20.63742914
90RIPK10.63661731
91VRK10.63479461
92AKT30.63427675
93TNIK0.62955549
94ACVR1B0.62852983
95CDK60.60883910
96CSNK1A1L0.60382272
97BRSK10.60227068
98MAPK90.59874464
99TAOK20.58150848
100VRK20.56590038
101AURKB0.56197218
102RPS6KB20.55839295
103CDK10.55741934
104CCNB10.55354983
105BMPR1B0.55257934
106PINK10.54454554
107PRKD20.54230368
108PTK20.54122258
109DYRK1A0.53805316
110PRKAA10.52925346
111RPS6KA10.52344480
112PRKCE0.51917573
113CHEK10.50784303
114SGK2230.50353346
115SGK4940.50353346
116CSNK1G20.50300558
117PRKCZ0.48706911
118PKN10.47394852
119NTRK10.47106187
120AKT20.46255051
121MKNK20.46079276
122CAMK40.46076295
123CSNK1A10.45788476
124NME10.45276972
125CAMK1D0.45050221
126CDK50.43717856
127PLK30.43418676
128PRKD30.41888931
129MAP2K60.41831030
130RPS6KC10.41763614
131RPS6KL10.41763614
132CSNK1E0.41341839
133MAP3K40.41130012
134ATM0.40895665
135CDK30.40408868
136CSNK1D0.39146707
137PRKDC0.37803891
138PKN20.37668666

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.52989569
2Hedgehog signaling pathway_Homo sapiens_hsa043403.25466539
3Hippo signaling pathway_Homo sapiens_hsa043902.87974901
4Steroid biosynthesis_Homo sapiens_hsa001002.86201895
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.73689326
6Spliceosome_Homo sapiens_hsa030402.67353904
7mRNA surveillance pathway_Homo sapiens_hsa030152.48035493
8Notch signaling pathway_Homo sapiens_hsa043302.43638348
9Mismatch repair_Homo sapiens_hsa034302.43205238
10Base excision repair_Homo sapiens_hsa034102.33016206
11Axon guidance_Homo sapiens_hsa043602.16823342
12DNA replication_Homo sapiens_hsa030302.15584886
13Wnt signaling pathway_Homo sapiens_hsa043102.15581058
14Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.11446653
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06783747
16Cell cycle_Homo sapiens_hsa041102.02660318
17Colorectal cancer_Homo sapiens_hsa052101.96114007
18RNA transport_Homo sapiens_hsa030131.90000317
19Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.80990759
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.77715463
21Oocyte meiosis_Homo sapiens_hsa041141.64781578
22Adherens junction_Homo sapiens_hsa045201.64055815
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.60830634
24Protein export_Homo sapiens_hsa030601.60275725
25Endometrial cancer_Homo sapiens_hsa052131.59811313
26mTOR signaling pathway_Homo sapiens_hsa041501.56045158
27MicroRNAs in cancer_Homo sapiens_hsa052061.48316832
28TGF-beta signaling pathway_Homo sapiens_hsa043501.47143394
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41908625
30Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.41434693
31Biosynthesis of amino acids_Homo sapiens_hsa012301.38557644
32Gap junction_Homo sapiens_hsa045401.36098987
33Melanogenesis_Homo sapiens_hsa049161.33605633
34Non-homologous end-joining_Homo sapiens_hsa034501.32242975
35Parkinsons disease_Homo sapiens_hsa050121.30625263
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30060004
37Oxidative phosphorylation_Homo sapiens_hsa001901.28994303
38Nucleotide excision repair_Homo sapiens_hsa034201.26994602
39Butanoate metabolism_Homo sapiens_hsa006501.24812662
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24278876
41Bladder cancer_Homo sapiens_hsa052191.22665000
42RNA polymerase_Homo sapiens_hsa030201.21134877
43Fatty acid biosynthesis_Homo sapiens_hsa000611.18301545
44Proteoglycans in cancer_Homo sapiens_hsa052051.15338568
45Viral myocarditis_Homo sapiens_hsa054161.12435523
46Tight junction_Homo sapiens_hsa045301.09618773
47Nicotine addiction_Homo sapiens_hsa050331.09003879
48Chronic myeloid leukemia_Homo sapiens_hsa052201.08863451
49Vibrio cholerae infection_Homo sapiens_hsa051101.08613710
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08274571
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07908247
52Lysine degradation_Homo sapiens_hsa003101.06677355
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.06328462
54Fanconi anemia pathway_Homo sapiens_hsa034601.05961950
55ErbB signaling pathway_Homo sapiens_hsa040121.05797011
56Huntingtons disease_Homo sapiens_hsa050161.03846262
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01839439
58Circadian rhythm_Homo sapiens_hsa047101.01486852
59VEGF signaling pathway_Homo sapiens_hsa043700.97275912
60Propanoate metabolism_Homo sapiens_hsa006400.97244387
61Phototransduction_Homo sapiens_hsa047440.96227904
62p53 signaling pathway_Homo sapiens_hsa041150.96060652
63Pathways in cancer_Homo sapiens_hsa052000.95423732
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93249601
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.93001684
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92348842
67HTLV-I infection_Homo sapiens_hsa051660.91591434
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90796833
69Cardiac muscle contraction_Homo sapiens_hsa042600.89842906
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87609851
71Arginine and proline metabolism_Homo sapiens_hsa003300.86104203
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85305978
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84824034
74Dopaminergic synapse_Homo sapiens_hsa047280.84613975
75Renal cell carcinoma_Homo sapiens_hsa052110.84467008
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84416990
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.84257249
78* Alcoholism_Homo sapiens_hsa050340.84123642
79N-Glycan biosynthesis_Homo sapiens_hsa005100.83702665
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.81364555
81Fatty acid elongation_Homo sapiens_hsa000620.80891516
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79392174
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79310114
84Selenocompound metabolism_Homo sapiens_hsa004500.79270090
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.78703397
86Glioma_Homo sapiens_hsa052140.78504586
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.78274347
88Taste transduction_Homo sapiens_hsa047420.77529483
89Fatty acid metabolism_Homo sapiens_hsa012120.76132988
90Pyrimidine metabolism_Homo sapiens_hsa002400.74385112
91Carbon metabolism_Homo sapiens_hsa012000.74307791
92Shigellosis_Homo sapiens_hsa051310.71529283
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71079149
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70777082
95Small cell lung cancer_Homo sapiens_hsa052220.70642065
96Estrogen signaling pathway_Homo sapiens_hsa049150.69988303
97Non-small cell lung cancer_Homo sapiens_hsa052230.69603240
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68679137
99Sulfur relay system_Homo sapiens_hsa041220.68628152
100Viral carcinogenesis_Homo sapiens_hsa052030.68142245
101Collecting duct acid secretion_Homo sapiens_hsa049660.67580246
102Melanoma_Homo sapiens_hsa052180.67305573
103Rap1 signaling pathway_Homo sapiens_hsa040150.66639290
104Cocaine addiction_Homo sapiens_hsa050300.66359081
105Basal transcription factors_Homo sapiens_hsa030220.65805273
106Glutamatergic synapse_Homo sapiens_hsa047240.65584452
107RNA degradation_Homo sapiens_hsa030180.65242734
108Morphine addiction_Homo sapiens_hsa050320.65016197
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64963645
110Insulin signaling pathway_Homo sapiens_hsa049100.63886332
111Prostate cancer_Homo sapiens_hsa052150.63515870
112Focal adhesion_Homo sapiens_hsa045100.62805189
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62625504
114Pyruvate metabolism_Homo sapiens_hsa006200.62281508
115GABAergic synapse_Homo sapiens_hsa047270.61142808
116Ribosome_Homo sapiens_hsa030100.59785645
117Thyroid cancer_Homo sapiens_hsa052160.59625904
118Homologous recombination_Homo sapiens_hsa034400.59326920
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58571833
120Pancreatic cancer_Homo sapiens_hsa052120.58122164
121Alzheimers disease_Homo sapiens_hsa050100.56610388
122AMPK signaling pathway_Homo sapiens_hsa041520.56135093
123Choline metabolism in cancer_Homo sapiens_hsa052310.54068105
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53839083
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53475478
126Circadian entrainment_Homo sapiens_hsa047130.53078322
127Synaptic vesicle cycle_Homo sapiens_hsa047210.52187712
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52066580
129MAPK signaling pathway_Homo sapiens_hsa040100.51475410
130Proteasome_Homo sapiens_hsa030500.50869101
131Peroxisome_Homo sapiens_hsa041460.50088449
132Amphetamine addiction_Homo sapiens_hsa050310.48488436
133Metabolic pathways_Homo sapiens_hsa011000.47284333
134Epstein-Barr virus infection_Homo sapiens_hsa051690.46235435
135Fat digestion and absorption_Homo sapiens_hsa049750.45831594
136GnRH signaling pathway_Homo sapiens_hsa049120.44357591
137Purine metabolism_Homo sapiens_hsa002300.44145310
138Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44059016
139Cholinergic synapse_Homo sapiens_hsa047250.43996677
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43726561
141Endocytosis_Homo sapiens_hsa041440.41314059
142Folate biosynthesis_Homo sapiens_hsa007900.40676844
143Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39811166
144Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38806451
145Cyanoamino acid metabolism_Homo sapiens_hsa004600.38016788
146Dilated cardiomyopathy_Homo sapiens_hsa054140.36545267
147Long-term potentiation_Homo sapiens_hsa047200.36182860
148beta-Alanine metabolism_Homo sapiens_hsa004100.36034864
149Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35951626
150Phenylalanine metabolism_Homo sapiens_hsa003600.35525888
151One carbon pool by folate_Homo sapiens_hsa006700.33267457

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