H2AFZ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.16519392
2telomere maintenance via semi-conservative replication (GO:0032201)5.05865764
3CENP-A containing nucleosome assembly (GO:0034080)4.95187626
4kinetochore organization (GO:0051383)4.92587076
5DNA strand elongation (GO:0022616)4.92064302
6chromatin remodeling at centromere (GO:0031055)4.81617001
7ribosomal small subunit assembly (GO:0000028)4.70495446
8telomere maintenance via recombination (GO:0000722)4.61958512
9DNA replication initiation (GO:0006270)4.61653488
10kinetochore assembly (GO:0051382)4.54620189
11protein localization to kinetochore (GO:0034501)4.48396323
12mitotic metaphase plate congression (GO:0007080)4.47167116
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.44662256
14mitotic recombination (GO:0006312)4.43800844
15DNA replication-independent nucleosome organization (GO:0034724)4.38381917
16DNA replication-independent nucleosome assembly (GO:0006336)4.38381917
17DNA replication checkpoint (GO:0000076)4.37371784
18DNA unwinding involved in DNA replication (GO:0006268)4.30111055
19DNA deamination (GO:0045006)4.26199778
20establishment of protein localization to mitochondrial membrane (GO:0090151)4.09145038
21protein localization to chromosome, centromeric region (GO:0071459)4.04369142
22histone exchange (GO:0043486)4.01713741
23telomere maintenance via telomere lengthening (GO:0010833)3.97322039
24maturation of SSU-rRNA (GO:0030490)3.96821874
25metaphase plate congression (GO:0051310)3.96760850
26chaperone-mediated protein transport (GO:0072321)3.96048135
27attachment of spindle microtubules to kinetochore (GO:0008608)3.91951113
28nucleobase biosynthetic process (GO:0046112)3.91933230
29deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.91025449
30nucleotide-excision repair, DNA gap filling (GO:0006297)3.89993573
31DNA double-strand break processing (GO:0000729)3.89977937
32viral transcription (GO:0019083)3.85144718
33DNA replication-dependent nucleosome assembly (GO:0006335)3.83392579
34DNA replication-dependent nucleosome organization (GO:0034723)3.83392579
35translational termination (GO:0006415)3.80765973
36purine nucleobase biosynthetic process (GO:0009113)3.80573759
37formation of translation preinitiation complex (GO:0001731)3.79901706
38establishment of chromosome localization (GO:0051303)3.75417674
39ATP synthesis coupled proton transport (GO:0015986)3.74171998
40energy coupled proton transport, down electrochemical gradient (GO:0015985)3.74171998
41ribosomal small subunit biogenesis (GO:0042274)3.73348852
42regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.72978289
43mitotic sister chromatid segregation (GO:0000070)3.66790978
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.66298665
45negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.65127668
46mitotic chromosome condensation (GO:0007076)3.58867028
47proteasome assembly (GO:0043248)3.58239947
48ribosomal large subunit biogenesis (GO:0042273)3.58206518
49mitotic spindle checkpoint (GO:0071174)3.57539183
50regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.57258382
51establishment of integrated proviral latency (GO:0075713)3.56079169
52regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.54576495
53regulation of mitotic spindle checkpoint (GO:1903504)3.54576495
54spliceosomal snRNP assembly (GO:0000387)3.51263428
55positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.50701927
56establishment of viral latency (GO:0019043)3.50534025
57cullin deneddylation (GO:0010388)3.48680484
58mitotic nuclear envelope disassembly (GO:0007077)3.48242928
59translational elongation (GO:0006414)3.46078292
60deoxyribonucleotide biosynthetic process (GO:0009263)3.41300942
61meiotic chromosome segregation (GO:0045132)3.40465909
62SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.39309466
63protein neddylation (GO:0045116)3.38704854
64translational initiation (GO:0006413)3.37552401
65regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.36494278
66sister chromatid segregation (GO:0000819)3.35956307
67transcription-coupled nucleotide-excision repair (GO:0006283)3.35800985
68signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.34511793
69signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.34511793
70signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.34511793
71ribonucleoprotein complex biogenesis (GO:0022613)3.34001944
72cotranslational protein targeting to membrane (GO:0006613)3.33373626
73negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.31204896
74negative regulation of ligase activity (GO:0051352)3.31204896
75cell cycle G1/S phase transition (GO:0044843)3.30630157
76G1/S transition of mitotic cell cycle (GO:0000082)3.30630157
77signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.30382100
78intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.30382100
79DNA catabolic process, exonucleolytic (GO:0000738)3.29804081
80spindle checkpoint (GO:0031577)3.28672566
81protein targeting to ER (GO:0045047)3.28601350
82viral mRNA export from host cell nucleus (GO:0046784)3.28282488
83spliceosomal complex assembly (GO:0000245)3.27354952
84regulation of cellular amino acid metabolic process (GO:0006521)3.26765064
85regulation of spindle organization (GO:0090224)3.26715341
86DNA damage response, detection of DNA damage (GO:0042769)3.25831819
87regulation of mitotic sister chromatid separation (GO:0010965)3.24855721
88regulation of mitotic sister chromatid segregation (GO:0033047)3.24855721
89regulation of sister chromatid segregation (GO:0033045)3.24855721
90signal transduction involved in DNA integrity checkpoint (GO:0072401)3.24651221
91signal transduction involved in DNA damage checkpoint (GO:0072422)3.24651221
92protein deneddylation (GO:0000338)3.24328313
93regulation of ubiquitin-protein transferase activity (GO:0051438)3.23850244
94negative regulation of DNA-dependent DNA replication (GO:2000104)3.23583474
95IMP biosynthetic process (GO:0006188)3.22731943
96signal transduction involved in cell cycle checkpoint (GO:0072395)3.22683337
97positive regulation of ligase activity (GO:0051351)3.22082838
98nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.20057618
99regulation of double-strand break repair via homologous recombination (GO:0010569)3.20038368
100replication fork processing (GO:0031297)3.19743720
101non-recombinational repair (GO:0000726)3.19520282
102double-strand break repair via nonhomologous end joining (GO:0006303)3.19520282
103DNA topological change (GO:0006265)3.19426018
104negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.19343259
105negative regulation of sister chromatid segregation (GO:0033046)3.19343259
106negative regulation of mitotic sister chromatid separation (GO:2000816)3.19343259
107negative regulation of mitotic sister chromatid segregation (GO:0033048)3.19343259
108membrane disassembly (GO:0030397)3.17984814
109nuclear envelope disassembly (GO:0051081)3.17984814
110mitotic G2/M transition checkpoint (GO:0044818)3.17315269
111negative regulation of chromosome segregation (GO:0051985)3.16656500
112rRNA processing (GO:0006364)3.16643637
113spindle assembly checkpoint (GO:0071173)3.14986625
114mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.13066176
115ribosome biogenesis (GO:0042254)3.12672682
116histone mRNA metabolic process (GO:0008334)3.12615540
117regulation of ligase activity (GO:0051340)3.11319451
118exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11225011
119regulation of mitochondrial translation (GO:0070129)3.10885012
120regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.10265989
121telomere organization (GO:0032200)3.10128947
122ATP-dependent chromatin remodeling (GO:0043044)3.09609351
123establishment of protein localization to endoplasmic reticulum (GO:0072599)3.09271848
124negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.09210833
125telomere maintenance (GO:0000723)3.09157531
126protein localization to endoplasmic reticulum (GO:0070972)3.08834824
127transcription elongation from RNA polymerase III promoter (GO:0006385)3.08649800
128mitotic spindle assembly checkpoint (GO:0007094)3.07328223
129cellular protein complex disassembly (GO:0043624)3.06637474
130chromatin assembly or disassembly (GO:0006333)3.05883083
131chromosome segregation (GO:0007059)3.05634775
132rRNA metabolic process (GO:0016072)3.05119495
133positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.04853417
134regulation of mitotic metaphase/anaphase transition (GO:0030071)3.04820710
135regulation of chromosome segregation (GO:0051983)3.04086901
136DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.04047399
137DNA ligation (GO:0006266)3.03477765
138viral life cycle (GO:0019058)3.03409696
139ribosome assembly (GO:0042255)3.01380721
140nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01262242

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.01244501
2* FOXM1_23109430_ChIP-Seq_U2OS_Human4.57278020
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.30330496
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.19347949
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.80037415
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.71003228
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.60236216
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.34520498
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.19150417
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.96353104
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.94717963
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.91687759
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.89932242
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.88792930
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.86833924
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.75195736
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.48886331
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.44132235
19* XRN2_22483619_ChIP-Seq_HELA_Human2.43895629
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39400039
21VDR_23849224_ChIP-Seq_CD4+_Human2.36870411
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.34880792
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.30408897
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.22809112
25* AR_21909140_ChIP-Seq_LNCAP_Human2.16338878
26DCP1A_22483619_ChIP-Seq_HELA_Human2.14568968
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10591040
28* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08930978
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07237833
30FOXP3_21729870_ChIP-Seq_TREG_Human2.06086856
31* E2F1_21310950_ChIP-Seq_MCF-7_Human2.03627466
32* TTF2_22483619_ChIP-Seq_HELA_Human1.95678332
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95036299
34ELK1_19687146_ChIP-ChIP_HELA_Human1.91764144
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86577407
36GABP_19822575_ChIP-Seq_HepG2_Human1.85907241
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85195253
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82599269
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79472858
40* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79263202
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.72439281
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72067569
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.68488876
44* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66378447
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65263100
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64712873
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62167864
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60178940
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60157236
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.59143142
51CIITA_25753668_ChIP-Seq_RAJI_Human1.56582253
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55707207
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55433034
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.53937855
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48713437
56EWS_26573619_Chip-Seq_HEK293_Human1.43188574
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.40286482
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39630767
59* NANOG_16153702_ChIP-ChIP_HESCs_Human1.33022440
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31680095
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31507738
62KDM5A_27292631_Chip-Seq_BREAST_Human1.31446754
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31163822
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30452267
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29285822
66* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28923849
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24333929
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.22987390
69SOX2_16153702_ChIP-ChIP_HESCs_Human1.21904487
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19282635
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17477626
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15177160
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14433721
74VDR_22108803_ChIP-Seq_LS180_Human1.12972242
75FUS_26573619_Chip-Seq_HEK293_Human1.12557118
76MYC_18940864_ChIP-ChIP_HL60_Human1.12098948
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10719403
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09799054
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08202631
80ZNF274_21170338_ChIP-Seq_K562_Hela1.06962216
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02546249
82MYC_22102868_ChIP-Seq_BL_Human1.01706328
83* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99690933
84KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98434760
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96903928
86STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95699359
87ELK1_22589737_ChIP-Seq_MCF10A_Human0.95476996
88* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94787799
89* TFEB_21752829_ChIP-Seq_HELA_Human0.92836843
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92802371
91POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92713094
92SPI1_23547873_ChIP-Seq_NB4_Human0.92637854
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92378437
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87625456
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86574773
96PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86560139
97SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.86010514
98* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85037816
99SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83548623
100IRF1_19129219_ChIP-ChIP_H3396_Human0.83392257
101NOTCH1_21737748_ChIP-Seq_TLL_Human0.81596148
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81536834
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78677852
104NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78012416
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.76038000
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.75183323
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74192860
108IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.73270367
109FLI1_27457419_Chip-Seq_LIVER_Mouse0.73222450
110VDR_21846776_ChIP-Seq_THP-1_Human0.72568055
111TCF3_18692474_ChIP-Seq_MEFs_Mouse0.72020667
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.71721849
113SOX17_20123909_ChIP-Seq_XEN_Mouse0.71691868
114NANOG_21062744_ChIP-ChIP_HESCs_Human0.70613326
115* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.69962942
116CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.69703100
117POU3F2_20337985_ChIP-ChIP_501MEL_Human0.68422059
118FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68376548
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.63906131
120TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.62750142
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.61331030
122* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.61056768
123* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.59161267
124P300_19829295_ChIP-Seq_ESCs_Human0.58862766
125NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.58714538

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.07537528
2MP0010094_abnormal_chromosome_stability5.12025242
3MP0003111_abnormal_nucleus_morphology4.70063396
4* MP0004957_abnormal_blastocyst_morpholog4.54318824
5MP0003077_abnormal_cell_cycle4.42431891
6MP0008057_abnormal_DNA_replication4.31931814
7MP0008058_abnormal_DNA_repair3.61229925
8MP0008007_abnormal_cellular_replicative3.20254209
9MP0008932_abnormal_embryonic_tissue3.01041728
10MP0000372_irregular_coat_pigmentation2.68954428
11MP0003136_yellow_coat_color2.58206431
12MP0003123_paternal_imprinting2.40278786
13MP0002396_abnormal_hematopoietic_system2.26121788
14MP0000350_abnormal_cell_proliferation2.17736127
15MP0001730_embryonic_growth_arrest2.11362235
16MP0008877_abnormal_DNA_methylation2.01130058
17MP0003786_premature_aging1.95925608
18MP0000490_abnormal_crypts_of1.78539884
19MP0010307_abnormal_tumor_latency1.62727759
20MP0001697_abnormal_embryo_size1.61083359
21MP0006072_abnormal_retinal_apoptosis1.60511561
22MP0000313_abnormal_cell_death1.53765433
23MP0010030_abnormal_orbit_morphology1.51651965
24MP0003718_maternal_effect1.50169638
25MP0001672_abnormal_embryogenesis/_devel1.48807775
26MP0005380_embryogenesis_phenotype1.48807775
27MP0004808_abnormal_hematopoietic_stem1.47747056
28MP0006292_abnormal_olfactory_placode1.44824189
29MP0003315_abnormal_perineum_morphology1.44501444
30* MP0002080_prenatal_lethality1.43404296
31MP0002019_abnormal_tumor_incidence1.42097058
32MP0009379_abnormal_foot_pigmentation1.39901468
33MP0010352_gastrointestinal_tract_polyps1.39444074
34MP0005408_hypopigmentation1.33433424
35* MP0002085_abnormal_embryonic_tissue1.31619408
36MP0003121_genomic_imprinting1.31355385
37MP0003984_embryonic_growth_retardation1.30486363
38MP0005394_taste/olfaction_phenotype1.27894061
39MP0005499_abnormal_olfactory_system1.27894061
40MP0005171_absent_coat_pigmentation1.27709198
41MP0002088_abnormal_embryonic_growth/wei1.26098519
42MP0009333_abnormal_splenocyte_physiolog1.25192480
43MP0003186_abnormal_redox_activity1.25112918
44MP0001293_anophthalmia1.24756718
45MP0006054_spinal_hemorrhage1.19758017
46MP0002210_abnormal_sex_determination1.14688248
47MP0003567_abnormal_fetal_cardiomyocyte1.14637087
48MP0003763_abnormal_thymus_physiology1.12745453
49MP0002233_abnormal_nose_morphology1.11691551
50MP0001188_hyperpigmentation1.11295957
51MP0002736_abnormal_nociception_after1.10257844
52MP0003890_abnormal_embryonic-extraembry1.10064080
53MP0003806_abnormal_nucleotide_metabolis1.09778043
54MP0002084_abnormal_developmental_patter1.09463014
55MP0000703_abnormal_thymus_morphology1.08731701
56MP0001545_abnormal_hematopoietic_system1.08675054
57MP0005397_hematopoietic_system_phenotyp1.08675054
58MP0002086_abnormal_extraembryonic_tissu1.08545123
59MP0004197_abnormal_fetal_growth/weight/1.08502450
60MP0002102_abnormal_ear_morphology1.08343118
61MP0002132_abnormal_respiratory_system1.06816763
62MP0002697_abnormal_eye_size1.06062228
63MP0002398_abnormal_bone_marrow1.05070597
64MP0005253_abnormal_eye_physiology1.03113609
65MP0009053_abnormal_anal_canal1.02976008
66MP0001145_abnormal_male_reproductive1.02169041
67MP0002160_abnormal_reproductive_system1.00419402
68MP0002938_white_spotting0.99213861
69MP0002722_abnormal_immune_system0.98220316
70MP0001485_abnormal_pinna_reflex0.96607232
71MP0001853_heart_inflammation0.95659963
72MP0004133_heterotaxia0.93750216
73MP0000566_synostosis0.93322165
74MP0000689_abnormal_spleen_morphology0.91305861
75MP0000858_altered_metastatic_potential0.90314472
76MP0001119_abnormal_female_reproductive0.87085844
77MP0005389_reproductive_system_phenotype0.85563092
78MP0005391_vision/eye_phenotype0.85491975
79MP0001929_abnormal_gametogenesis0.85424901
80MP0000537_abnormal_urethra_morphology0.84871156
81MP0000653_abnormal_sex_gland0.84533151
82MP0002429_abnormal_blood_cell0.84455596
83MP0002090_abnormal_vision0.83669215
84MP0000647_abnormal_sebaceous_gland0.83637020
85MP0003880_abnormal_central_pattern0.83516261
86MP0001324_abnormal_eye_pigmentation0.82287343
87MP0000358_abnormal_cell_content/0.80394222
88MP0006036_abnormal_mitochondrial_physio0.80233961
89MP0002095_abnormal_skin_pigmentation0.80105629
90MP0008995_early_reproductive_senescence0.80009194
91MP0000631_abnormal_neuroendocrine_gland0.79407665
92MP0005076_abnormal_cell_differentiation0.79075511
93MP0003755_abnormal_palate_morphology0.78598835
94MP0005084_abnormal_gallbladder_morpholo0.78573040
95MP0001177_atelectasis0.77117451
96MP0003119_abnormal_digestive_system0.74776894
97MP0002234_abnormal_pharynx_morphology0.74197086
98MP0000049_abnormal_middle_ear0.73601885
99MP0009697_abnormal_copulation0.73585431
100MP0008789_abnormal_olfactory_epithelium0.73069226
101MP0006035_abnormal_mitochondrial_morpho0.72980560
102MP0001835_abnormal_antigen_presentation0.72855780
103MP0000716_abnormal_immune_system0.70613656
104MP0002111_abnormal_tail_morphology0.70534260
105MP0003941_abnormal_skin_development0.70533265
106MP0002751_abnormal_autonomic_nervous0.70450312
107MP0003861_abnormal_nervous_system0.69802165
108MP0001529_abnormal_vocalization0.68350262
109MP0005384_cellular_phenotype0.68127497
110MP0001286_abnormal_eye_development0.68085549
111MP0009703_decreased_birth_body0.67846930
112MP0003937_abnormal_limbs/digits/tail_de0.67134748
113MP0001764_abnormal_homeostasis0.66567993
114MP0001346_abnormal_lacrimal_gland0.66543933
115MP0003011_delayed_dark_adaptation0.66440921
116MP0003698_abnormal_male_reproductive0.66436999
117MP0002282_abnormal_trachea_morphology0.66101922
118MP0002092_abnormal_eye_morphology0.65249936
119MP0000579_abnormal_nail_morphology0.63255613
120MP0002163_abnormal_gland_morphology0.62986288
121MP0005248_abnormal_Harderian_gland0.61011574
122MP0001919_abnormal_reproductive_system0.59876103
123MP0005174_abnormal_tail_pigmentation0.59490645
124MP0009672_abnormal_birth_weight0.58539919
125MP0004147_increased_porphyrin_level0.58443977
126MP0005075_abnormal_melanosome_morpholog0.56565512
127MP0001984_abnormal_olfaction0.56033955
128MP0005671_abnormal_response_to0.55994913
129MP0005621_abnormal_cell_physiology0.55978925
130MP0002420_abnormal_adaptive_immunity0.55660601
131MP0001819_abnormal_immune_cell0.54930493
132MP0002006_tumorigenesis0.52993664
133MP0000428_abnormal_craniofacial_morphol0.50674829
134MP0001727_abnormal_embryo_implantation0.50582902
135MP0003938_abnormal_ear_development0.50444906

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.26453959
2Reticulocytopenia (HP:0001896)4.63833571
3Abnormality of cells of the erythroid lineage (HP:0012130)4.40741288
4Abnormal number of erythroid precursors (HP:0012131)4.28820922
5Breast hypoplasia (HP:0003187)3.96475257
6Oral leukoplakia (HP:0002745)3.81631964
7Acute encephalopathy (HP:0006846)3.74096144
8Chromsome breakage (HP:0040012)3.66670371
9Colon cancer (HP:0003003)3.61727686
10Patellar aplasia (HP:0006443)3.52472370
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.51451505
12Aplastic anemia (HP:0001915)3.41681336
13Progressive macrocephaly (HP:0004481)3.32395870
14Aplasia/Hypoplasia of the patella (HP:0006498)3.30149949
15Degeneration of anterior horn cells (HP:0002398)3.27221295
16Abnormality of the anterior horn cell (HP:0006802)3.27221295
17Meckel diverticulum (HP:0002245)3.22297798
18Carpal bone hypoplasia (HP:0001498)3.19969019
19Abnormality of chromosome stability (HP:0003220)3.17502254
20Selective tooth agenesis (HP:0001592)3.10365897
21Abnormality of the ileum (HP:0001549)3.08314783
22Abnormality of the preputium (HP:0100587)3.04744188
23Lipid accumulation in hepatocytes (HP:0006561)2.99597382
2411 pairs of ribs (HP:0000878)2.95776982
25Macrocytic anemia (HP:0001972)2.94458688
26Pallor (HP:0000980)2.92926085
27Rough bone trabeculation (HP:0100670)2.91560580
28Abnormal lung lobation (HP:0002101)2.88814128
29Abnormal number of incisors (HP:0011064)2.88561172
30Small intestinal stenosis (HP:0012848)2.83100835
31Duodenal stenosis (HP:0100867)2.83100835
32Cerebral edema (HP:0002181)2.83040312
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.81006353
34Medulloblastoma (HP:0002885)2.79443833
35Hepatic necrosis (HP:0002605)2.65890553
36Myelodysplasia (HP:0002863)2.64881072
37Premature graying of hair (HP:0002216)2.63160574
38Increased serum pyruvate (HP:0003542)2.59284025
39Agnosia (HP:0010524)2.57668906
40Microretrognathia (HP:0000308)2.57655456
41Absent radius (HP:0003974)2.57184261
42Absent thumb (HP:0009777)2.54465554
43Bone marrow hypocellularity (HP:0005528)2.53861204
44Aplasia/Hypoplasia of the sacrum (HP:0008517)2.49274747
45Renal Fanconi syndrome (HP:0001994)2.42316566
46Cellular immunodeficiency (HP:0005374)2.41115394
47Cleft eyelid (HP:0000625)2.41094324
48Abnormality of glycolysis (HP:0004366)2.40994738
49Volvulus (HP:0002580)2.40465531
50Septo-optic dysplasia (HP:0100842)2.39502887
51Absent forearm bone (HP:0003953)2.39216757
52Aplasia involving forearm bones (HP:0009822)2.39216757
53Congenital, generalized hypertrichosis (HP:0004540)2.38471796
54Triphalangeal thumb (HP:0001199)2.36879298
55Neoplasm of the pancreas (HP:0002894)2.36695663
56Horseshoe kidney (HP:0000085)2.32317173
57Abnormality of the duodenum (HP:0002246)2.32007041
58Tracheoesophageal fistula (HP:0002575)2.28909016
59Cerebral hypomyelination (HP:0006808)2.28693759
60Sloping forehead (HP:0000340)2.26790883
61Cortical dysplasia (HP:0002539)2.24706462
62Microvesicular hepatic steatosis (HP:0001414)2.24476615
63Atresia of the external auditory canal (HP:0000413)2.21554342
64Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.20042869
65Decreased activity of mitochondrial respiratory chain (HP:0008972)2.20042869
66Lactic acidosis (HP:0003128)2.19138335
67Leukodystrophy (HP:0002415)2.18749527
68Hypoplastic pelvis (HP:0008839)2.16617997
69Methylmalonic acidemia (HP:0002912)2.16584564
70Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.16566817
71Abnormality of methionine metabolism (HP:0010901)2.16433030
72Abnormal trabecular bone morphology (HP:0100671)2.15374512
73Hyperglycinemia (HP:0002154)2.14135034
74Impulsivity (HP:0100710)2.14028841
75Supernumerary spleens (HP:0009799)2.13151073
76IgM deficiency (HP:0002850)2.11694997
77Hypoplasia of the capital femoral epiphysis (HP:0003090)2.11436556
78Type I transferrin isoform profile (HP:0003642)2.10894153
79Nephroblastoma (Wilms tumor) (HP:0002667)2.10038567
80Trismus (HP:0000211)2.09760089
81Ectopic kidney (HP:0000086)2.07455609
82Pancytopenia (HP:0001876)2.04636362
83Duplicated collecting system (HP:0000081)2.03998441
84Abnormality of serum amino acid levels (HP:0003112)2.02732071
85Respiratory failure (HP:0002878)2.00619443
86Acute necrotizing encephalopathy (HP:0006965)2.00301707
87Exercise intolerance (HP:0003546)1.99410638
88Megaloblastic anemia (HP:0001889)1.98954216
89Methylmalonic aciduria (HP:0012120)1.98299973
90Lymphoma (HP:0002665)1.97452342
91Increased serum lactate (HP:0002151)1.97302594
92Optic nerve coloboma (HP:0000588)1.97064053
93Embryonal renal neoplasm (HP:0011794)1.96358128
94Absent septum pellucidum (HP:0001331)1.96084315
95Mitochondrial inheritance (HP:0001427)1.94506566
96Increased nuchal translucency (HP:0010880)1.94178553
97Poor head control (HP:0002421)1.93765818
98Neoplasm of the colon (HP:0100273)1.93545975
99Respiratory difficulties (HP:0002880)1.93219526
100Increased CSF lactate (HP:0002490)1.92973597
101Increased intramyocellular lipid droplets (HP:0012240)1.92528479
102Ependymoma (HP:0002888)1.89934937
103Abnormality of the labia minora (HP:0012880)1.88170553
104Short thumb (HP:0009778)1.88162238
105Short middle phalanx of the 5th finger (HP:0004220)1.87776245
106Hypoplasia of the pons (HP:0012110)1.87272089
107Aplasia/Hypoplasia of the sternum (HP:0006714)1.87054007
108Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.86875381
109Multiple enchondromatosis (HP:0005701)1.86796791
110Abnormality of the heme biosynthetic pathway (HP:0010472)1.85720886
111Abnormality of the renal collecting system (HP:0004742)1.85167238
112Abnormality of the septum pellucidum (HP:0007375)1.84506608
113Abnormal mitochondria in muscle tissue (HP:0008316)1.84345363
114Rhabdomyosarcoma (HP:0002859)1.84110044
115Thrombocytosis (HP:0001894)1.83058701
116Slender long bone (HP:0003100)1.83047456
117Glossoptosis (HP:0000162)1.82993296
118Optic disc pallor (HP:0000543)1.81486468
1193-Methylglutaconic aciduria (HP:0003535)1.81476137
120Abnormality of the carotid arteries (HP:0005344)1.81047115
121Intestinal atresia (HP:0011100)1.80595004
122Increased hepatocellular lipid droplets (HP:0006565)1.80374010
123Reduced antithrombin III activity (HP:0001976)1.80338023
124Abnormal protein glycosylation (HP:0012346)1.80316650
125Abnormal glycosylation (HP:0012345)1.80316650
126Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80316650
127Abnormal protein N-linked glycosylation (HP:0012347)1.80316650
128Neoplasm of the adrenal gland (HP:0100631)1.78629768
129Abnormality of the pons (HP:0007361)1.78298065
130Hepatocellular necrosis (HP:0001404)1.77746874
131Bifid tongue (HP:0010297)1.76573441
132Clubbing of toes (HP:0100760)1.76044496
133Secondary amenorrhea (HP:0000869)1.76020164
134Atrophy/Degeneration involving motor neurons (HP:0007373)1.75955924
135Abnormality of aspartate family amino acid metabolism (HP:0010899)1.75565875
136Exertional dyspnea (HP:0002875)1.74976291
137Hypoplasia of the radius (HP:0002984)1.74168997
138Facial cleft (HP:0002006)1.73873178
139Abnormality of the fetal cardiovascular system (HP:0010948)1.72884123
140Single umbilical artery (HP:0001195)1.72884123
141Short 4th metacarpal (HP:0010044)1.72257100
142Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.72257100
143Proximal placement of thumb (HP:0009623)1.71636079
144Missing ribs (HP:0000921)1.68760156

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.43781259
2WEE14.63754275
3CDC73.92039456
4EIF2AK13.75320227
5VRK23.53869153
6SRPK12.85587611
7STK162.75737501
8BRSK22.56568019
9VRK12.54146524
10NEK22.43543681
11TRIM282.42455444
12PLK42.37651955
13EIF2AK32.36241622
14CCNB12.33036258
15NEK12.22549296
16NME22.22108811
17TTK2.21869892
18ACVR1B2.00462290
19PLK11.99919274
20MKNK11.99714316
21TESK21.88250110
22WNK31.83137183
23AURKB1.80448059
24BRSK11.79786301
25TLK11.78552118
26TSSK61.73992157
27NUAK11.71721333
28PLK31.70389197
29PASK1.61313901
30PBK1.60680070
31TAF11.59569147
32ATR1.58485428
33DYRK31.56040745
34CDK71.52132372
35RPS6KA41.46255441
36TNIK1.44381935
37AURKA1.27752689
38BMPR1B1.27394116
39CHEK21.25414568
40PAK41.20691008
41MKNK21.20417497
42EIF2AK21.19752333
43MAP3K81.15329642
44CDK81.11955487
45STK41.11186932
46RPS6KB21.02548828
47PLK21.02531519
48ZAK1.01840747
49CHEK10.98066832
50CDK40.94713438
51NME10.92693505
52TESK10.89549231
53PIM20.89534363
54KDR0.88139428
55CSNK1G10.85929484
56STK100.84642840
57TGFBR10.84475391
58MAP4K20.83895141
59CSNK1G30.83040826
60BRAF0.81254539
61CLK10.76075080
62SCYL20.73969698
63CSNK2A10.73945068
64CSNK1G20.71425076
65PIM10.70616588
66ATM0.70120407
67PDK20.69763566
68MELK0.65351683
69CDK20.65006299
70MST40.64672512
71CSNK2A20.62788650
72CDK10.57650132
73YES10.57592152
74PAK10.57231107
75CSNK1A1L0.57137830
76RPS6KA50.55580173
77MAP3K120.55533079
78IRAK40.54278837
79DYRK20.53748877
80STK30.52232379
81MINK10.51549039
82EPHA20.50278157
83MAP4K10.50068583
84ALK0.48967897
85LRRK20.48634888
86CDK60.48329217
87MAP3K110.45238654
88CDK30.42839079
89ABL20.40829970
90TEC0.40059758
91MAP2K70.40056493
92ERBB40.38925079
93GRK10.38676325
94PNCK0.38397608
95PRKCI0.38215055
96BTK0.38058717
97ERBB30.37504854
98INSRR0.35976462
99MARK30.35658475
100ILK0.35600381
101LIMK10.35557882
102CSNK1E0.34003769
103PRKCG0.33777706
104MAP3K100.33429229
105TAOK20.33002077
106STK38L0.32783823
107DAPK10.30966921
108MAP3K40.30956702
109BLK0.30585223
110FGFR10.29463616
111FLT30.29427102
112NEK90.28911876
113OXSR10.28478587
114BRD40.26015301
115MAPK130.25678633
116TXK0.24606063
117LYN0.24207729
118BCR0.22685576
119SIK30.22606758
120CSNK1A10.22255715
121UHMK10.21249595
122PRKDC0.19853104
123BCKDK0.19697226
124CDK180.18959816
125AKT20.18822368
126CDK11A0.18800390
127RPS6KL10.18297818
128RPS6KC10.18297818
129RPS6KA60.17356393
130MAPKAPK20.17305918
131CDK150.15936424
132CDK140.15738694

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.33629863
2Mismatch repair_Homo sapiens_hsa034304.51101286
3Proteasome_Homo sapiens_hsa030503.97194008
4Ribosome_Homo sapiens_hsa030103.91417532
5Spliceosome_Homo sapiens_hsa030403.47479939
6Homologous recombination_Homo sapiens_hsa034403.37627973
7RNA polymerase_Homo sapiens_hsa030203.26614666
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.22423690
9Base excision repair_Homo sapiens_hsa034103.16642819
10Nucleotide excision repair_Homo sapiens_hsa034202.94573197
11RNA transport_Homo sapiens_hsa030132.83487934
12Cell cycle_Homo sapiens_hsa041102.79360298
13Pyrimidine metabolism_Homo sapiens_hsa002402.69684844
14Fanconi anemia pathway_Homo sapiens_hsa034602.32480592
15One carbon pool by folate_Homo sapiens_hsa006702.19054631
16Non-homologous end-joining_Homo sapiens_hsa034502.13064851
17RNA degradation_Homo sapiens_hsa030181.95989560
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.95794950
19Basal transcription factors_Homo sapiens_hsa030221.85072015
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62917397
21p53 signaling pathway_Homo sapiens_hsa041151.56947696
22Propanoate metabolism_Homo sapiens_hsa006401.43918386
23mRNA surveillance pathway_Homo sapiens_hsa030151.43908329
24Purine metabolism_Homo sapiens_hsa002301.42681453
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41755214
26Pyruvate metabolism_Homo sapiens_hsa006201.40960497
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40917424
28Protein export_Homo sapiens_hsa030601.38903477
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29470226
30Steroid biosynthesis_Homo sapiens_hsa001001.28674629
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27222427
32Parkinsons disease_Homo sapiens_hsa050121.26790906
33Epstein-Barr virus infection_Homo sapiens_hsa051691.20965462
34Huntingtons disease_Homo sapiens_hsa050161.16174466
35* Systemic lupus erythematosus_Homo sapiens_hsa053221.14967480
36Fatty acid elongation_Homo sapiens_hsa000621.13226180
37Oxidative phosphorylation_Homo sapiens_hsa001901.11079561
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09285647
39Oocyte meiosis_Homo sapiens_hsa041140.99961289
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95489548
41Herpes simplex infection_Homo sapiens_hsa051680.87658481
42Viral carcinogenesis_Homo sapiens_hsa052030.81614983
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81319468
44Cardiac muscle contraction_Homo sapiens_hsa042600.80999696
45Antigen processing and presentation_Homo sapiens_hsa046120.78372302
46Folate biosynthesis_Homo sapiens_hsa007900.76600717
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74722416
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72453435
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66413502
50HTLV-I infection_Homo sapiens_hsa051660.66193705
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.65513781
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.64564199
53Pentose phosphate pathway_Homo sapiens_hsa000300.63859717
54Legionellosis_Homo sapiens_hsa051340.63359309
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57500193
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57490745
57Glutathione metabolism_Homo sapiens_hsa004800.56800617
58Alzheimers disease_Homo sapiens_hsa050100.54297627
59Biosynthesis of amino acids_Homo sapiens_hsa012300.49287177
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49108847
61Primary immunodeficiency_Homo sapiens_hsa053400.48750485
62Butanoate metabolism_Homo sapiens_hsa006500.48603415
63N-Glycan biosynthesis_Homo sapiens_hsa005100.48161325
64Selenocompound metabolism_Homo sapiens_hsa004500.46822370
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.46099171
66Thyroid cancer_Homo sapiens_hsa052160.44100588
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42887277
68Small cell lung cancer_Homo sapiens_hsa052220.42734014
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42551409
70* Alcoholism_Homo sapiens_hsa050340.42467752
71Peroxisome_Homo sapiens_hsa041460.41118751
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40929327
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40447690
74Phototransduction_Homo sapiens_hsa047440.39598112
75Fatty acid metabolism_Homo sapiens_hsa012120.39047602
76Apoptosis_Homo sapiens_hsa042100.36929446
77MicroRNAs in cancer_Homo sapiens_hsa052060.36459955
78Measles_Homo sapiens_hsa051620.35391386
79Sulfur relay system_Homo sapiens_hsa041220.35299606
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34499847
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33047482
82Sulfur metabolism_Homo sapiens_hsa009200.32885775
83Fatty acid degradation_Homo sapiens_hsa000710.32063921
84Hepatitis B_Homo sapiens_hsa051610.30968239
85Basal cell carcinoma_Homo sapiens_hsa052170.30243244
86Vitamin digestion and absorption_Homo sapiens_hsa049770.30005834
87Shigellosis_Homo sapiens_hsa051310.29533478
88Tryptophan metabolism_Homo sapiens_hsa003800.29503698
89Carbon metabolism_Homo sapiens_hsa012000.29100092
90Arginine and proline metabolism_Homo sapiens_hsa003300.27578805
91Asthma_Homo sapiens_hsa053100.27475016
92beta-Alanine metabolism_Homo sapiens_hsa004100.27445105
93Metabolic pathways_Homo sapiens_hsa011000.26817143
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26633595
95Wnt signaling pathway_Homo sapiens_hsa043100.26343949
96Allograft rejection_Homo sapiens_hsa053300.25168605
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.23778871
98TGF-beta signaling pathway_Homo sapiens_hsa043500.23649283
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23595405
100Colorectal cancer_Homo sapiens_hsa052100.23430987
101Hematopoietic cell lineage_Homo sapiens_hsa046400.23414458
102Vitamin B6 metabolism_Homo sapiens_hsa007500.22623606
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.22240782
104Arachidonic acid metabolism_Homo sapiens_hsa005900.20803248
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20324334
106Hippo signaling pathway_Homo sapiens_hsa043900.19436252
107Graft-versus-host disease_Homo sapiens_hsa053320.18384817
108Tyrosine metabolism_Homo sapiens_hsa003500.18317539
109Influenza A_Homo sapiens_hsa051640.18057826
110Renin-angiotensin system_Homo sapiens_hsa046140.17957121
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17430007
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17121820
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.14511472
114Viral myocarditis_Homo sapiens_hsa054160.14511088
115Fructose and mannose metabolism_Homo sapiens_hsa000510.14416233
116Pathways in cancer_Homo sapiens_hsa052000.14126008
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13132178
118Regulation of autophagy_Homo sapiens_hsa041400.13007277
119Nitrogen metabolism_Homo sapiens_hsa009100.12647802
120Hedgehog signaling pathway_Homo sapiens_hsa043400.12632980
121Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.12536359
122Chemical carcinogenesis_Homo sapiens_hsa052040.11945844
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.11927213
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.09885690
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09805016
126Caffeine metabolism_Homo sapiens_hsa002320.09210884
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.09036413
128Retinol metabolism_Homo sapiens_hsa008300.08831430
129Notch signaling pathway_Homo sapiens_hsa043300.07844885
130HIF-1 signaling pathway_Homo sapiens_hsa040660.07713333
131Collecting duct acid secretion_Homo sapiens_hsa049660.07356811
132Type I diabetes mellitus_Homo sapiens_hsa049400.07321067
133Autoimmune thyroid disease_Homo sapiens_hsa053200.07212523
134SNARE interactions in vesicular transport_Homo sapiens_hsa041300.06859439
135Bladder cancer_Homo sapiens_hsa052190.06697736
136Leishmaniasis_Homo sapiens_hsa051400.06645402
137Fat digestion and absorption_Homo sapiens_hsa049750.06113729
138Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.03191790
139Lysine degradation_Homo sapiens_hsa003100.02371621

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »