H2AFZP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.47238684
2cytidine metabolic process (GO:0046087)6.53756252
3cytidine catabolic process (GO:0006216)6.53756252
4cytidine deamination (GO:0009972)6.53756252
5DNA deamination (GO:0045006)6.33538865
6DNA ligation (GO:0006266)5.84112954
7pyrimidine ribonucleoside catabolic process (GO:0046133)5.72615219
8proteasome assembly (GO:0043248)5.64060109
9establishment of protein localization to mitochondrial membrane (GO:0090151)4.67901873
10chromatin remodeling at centromere (GO:0031055)4.37361906
11signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.36614942
12signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.36614942
13signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.36614942
14positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.33976220
15CENP-A containing nucleosome assembly (GO:0034080)4.31619477
16DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.29879714
17regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.28419087
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.25655984
19negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.24250129
20signal transduction involved in DNA damage checkpoint (GO:0072422)4.21075934
21signal transduction involved in DNA integrity checkpoint (GO:0072401)4.21075934
22signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.19725470
23intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.19725470
24anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.16086818
25signal transduction involved in cell cycle checkpoint (GO:0072395)4.15849053
26regulation of cellular amino acid metabolic process (GO:0006521)3.94764967
27ATP synthesis coupled proton transport (GO:0015986)3.93316078
28energy coupled proton transport, down electrochemical gradient (GO:0015985)3.93316078
29negative regulation of B cell proliferation (GO:0030889)3.82537862
30negative regulation of ligase activity (GO:0051352)3.82527943
31negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.82527943
32positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.72222012
33histone exchange (GO:0043486)3.71581459
34positive regulation of ligase activity (GO:0051351)3.63639324
35kinetochore organization (GO:0051383)3.62276270
36regulation of nuclear cell cycle DNA replication (GO:0033262)3.58949332
37somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.57860173
38somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.57860173
39isotype switching (GO:0045190)3.57860173
40kinetochore assembly (GO:0051382)3.56866748
41positive regulation of cell cycle arrest (GO:0071158)3.47545318
42positive regulation of interleukin-8 secretion (GO:2000484)3.47279041
43DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.45521234
44rRNA modification (GO:0000154)3.42185748
45establishment of integrated proviral latency (GO:0075713)3.41370720
46rRNA methylation (GO:0031167)3.41012367
47replication fork processing (GO:0031297)3.40047371
48protein localization to kinetochore (GO:0034501)3.31829750
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.31795748
50sequestering of actin monomers (GO:0042989)3.30161389
51regulation of ubiquitin-protein transferase activity (GO:0051438)3.28670928
52nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.26950761
53regulation of ligase activity (GO:0051340)3.23406731
54antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.21603394
55respiratory electron transport chain (GO:0022904)3.19847495
56electron transport chain (GO:0022900)3.16819991
57microtubule depolymerization (GO:0007019)3.09409059
58intestinal epithelial cell development (GO:0060576)3.04461694
59viral mRNA export from host cell nucleus (GO:0046784)3.03345315
60replicative senescence (GO:0090399)3.02411616
61protein K6-linked ubiquitination (GO:0085020)3.00140586
62protein complex biogenesis (GO:0070271)2.98982994
63mitotic metaphase plate congression (GO:0007080)2.97308270
64DNA demethylation (GO:0080111)2.96873232
65antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.96691864
66transcription elongation from RNA polymerase III promoter (GO:0006385)2.96150276
67termination of RNA polymerase III transcription (GO:0006386)2.96150276
68signal transduction in response to DNA damage (GO:0042770)2.95614710
69exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93275228
70DNA replication-independent nucleosome organization (GO:0034724)2.91750329
71DNA replication-independent nucleosome assembly (GO:0006336)2.91750329
72regulation of cellular amine metabolic process (GO:0033238)2.86476132
73metaphase plate congression (GO:0051310)2.85029151
74regulation of cell cycle arrest (GO:0071156)2.83333167
75mitochondrial respiratory chain complex assembly (GO:0033108)2.81692519
76regulation of helicase activity (GO:0051095)2.81298442
77cullin deneddylation (GO:0010388)2.81199826
78negative regulation of heart rate (GO:0010459)2.80172119
79somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.76714785
80somatic cell DNA recombination (GO:0016444)2.76714785
81negative regulation by host of viral transcription (GO:0043922)2.74001477
82spindle checkpoint (GO:0031577)2.72416274
83metallo-sulfur cluster assembly (GO:0031163)2.71945021
84iron-sulfur cluster assembly (GO:0016226)2.71945021
85pyrimidine nucleoside catabolic process (GO:0046135)2.70410624
86negative regulation of protein ubiquitination (GO:0031397)2.69796401
87DNA integration (GO:0015074)2.69733459
88intra-S DNA damage checkpoint (GO:0031573)2.67947098
89maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.67345649
90maturation of 5.8S rRNA (GO:0000460)2.66561550
91somatic diversification of immune receptors (GO:0002200)2.65593675
92DNA catabolic process, exonucleolytic (GO:0000738)2.64617057
93regulation of mitochondrial translation (GO:0070129)2.64393803
94positive regulation of protein ubiquitination (GO:0031398)2.63495329
95negative regulation of T cell differentiation in thymus (GO:0033085)2.62353806
96V(D)J recombination (GO:0033151)2.61682331
97DNA topological change (GO:0006265)2.60888441
98response to nitrosative stress (GO:0051409)2.60365234
99pseudouridine synthesis (GO:0001522)2.58445207
100protein neddylation (GO:0045116)2.58421307

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.90433134
2E2F7_22180533_ChIP-Seq_HELA_Human4.37842823
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.30296473
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.73669056
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.68956433
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.42829681
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.17938003
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.14253594
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.04269611
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.81179236
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.73423752
12ELK1_19687146_ChIP-ChIP_HELA_Human2.71671291
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70452782
14VDR_22108803_ChIP-Seq_LS180_Human2.61197737
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.55102950
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44867048
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.44764557
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39513259
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.35399729
20VDR_23849224_ChIP-Seq_CD4+_Human2.27746470
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.25259381
22IGF1R_20145208_ChIP-Seq_DFB_Human2.11308916
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.07641420
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02442885
25FOXP3_21729870_ChIP-Seq_TREG_Human1.98188817
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.90198709
27POU5F1_16153702_ChIP-ChIP_HESCs_Human1.75235037
28EWS_26573619_Chip-Seq_HEK293_Human1.68162316
29MYC_18940864_ChIP-ChIP_HL60_Human1.55280460
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55102764
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.54994095
32DCP1A_22483619_ChIP-Seq_HELA_Human1.52312100
33FUS_26573619_Chip-Seq_HEK293_Human1.48011716
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47772546
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47259310
36AR_21909140_ChIP-Seq_LNCAP_Human1.46631031
37ZNF274_21170338_ChIP-Seq_K562_Hela1.37189147
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36438432
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36267188
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35769640
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.30601801
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30499484
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28520222
44ELK1_22589737_ChIP-Seq_MCF10A_Human1.26626871
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.26287610
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25807995
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25034620
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24681164
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24271727
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23019784
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.22889299
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22740843
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20710511
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18910953
55NANOG_16153702_ChIP-ChIP_HESCs_Human1.18687348
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18179376
57IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17960851
58TTF2_22483619_ChIP-Seq_HELA_Human1.17644888
59P300_19829295_ChIP-Seq_ESCs_Human1.17094425
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.16665490
61HTT_18923047_ChIP-ChIP_STHdh_Human1.16367929
62SOX2_19829295_ChIP-Seq_ESCs_Human1.14772135
63NANOG_19829295_ChIP-Seq_ESCs_Human1.14772135
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10921827
65KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10222618
66KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10222618
67KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10222618
68ER_23166858_ChIP-Seq_MCF-7_Human1.09539125
69GABP_19822575_ChIP-Seq_HepG2_Human1.09315750
70AR_21572438_ChIP-Seq_LNCaP_Human1.06388830
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.05828818
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05421816
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.03978956
74NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03293945
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02254228
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.01660923
77AR_20517297_ChIP-Seq_VCAP_Human1.01497388
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01462672
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99581961
80GATA3_26560356_Chip-Seq_TH2_Human0.98288643
81TP53_22573176_ChIP-Seq_HFKS_Human0.97257213
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.97152270
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97072510
84XRN2_22483619_ChIP-Seq_HELA_Human0.96727297
85IRF8_21731497_ChIP-ChIP_J774_Mouse0.95083959
86FOXA1_25329375_ChIP-Seq_VCAP_Human0.94456817
87FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94456817
88ZFP57_27257070_Chip-Seq_ESCs_Mouse0.94245858
89BCAT_22108803_ChIP-Seq_LS180_Human0.94013377
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93065924
91EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89788930
92FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89095172
93CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88738305
94NFE2_27457419_Chip-Seq_LIVER_Mouse0.86842781
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86347228
96SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86111778
97SOX2_16153702_ChIP-ChIP_HESCs_Human0.85528805
98HOXB7_26014856_ChIP-Seq_BT474_Human0.85075238
99CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84481662
100CBP_20019798_ChIP-Seq_JUKART_Human0.84001464

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology5.52748939
2MP0008058_abnormal_DNA_repair2.96930444
3MP0000372_irregular_coat_pigmentation2.71152265
4MP0005671_abnormal_response_to2.66279411
5MP0003878_abnormal_ear_physiology2.58755991
6MP0005377_hearing/vestibular/ear_phenot2.58755991
7MP0006072_abnormal_retinal_apoptosis2.41297443
8MP0008877_abnormal_DNA_methylation2.24796534
9MP0010094_abnormal_chromosome_stability2.24284405
10MP0006292_abnormal_olfactory_placode2.18096226
11MP0003136_yellow_coat_color2.14472981
12MP0003763_abnormal_thymus_physiology2.11042206
13MP0004957_abnormal_blastocyst_morpholog2.10728033
14MP0004147_increased_porphyrin_level2.07435656
15MP0003890_abnormal_embryonic-extraembry2.01359008
16MP0002736_abnormal_nociception_after1.98234184
17MP0003567_abnormal_fetal_cardiomyocyte1.95654467
18MP0002138_abnormal_hepatobiliary_system1.94502277
19MP0005075_abnormal_melanosome_morpholog1.89290995
20MP0001485_abnormal_pinna_reflex1.86814903
21MP0004742_abnormal_vestibular_system1.79604696
22MP0003693_abnormal_embryo_hatching1.78567578
23MP0003077_abnormal_cell_cycle1.65223033
24MP0002234_abnormal_pharynx_morphology1.59257588
25MP0003880_abnormal_central_pattern1.57778653
26MP0000569_abnormal_digit_pigmentation1.55657745
27MP0008057_abnormal_DNA_replication1.54633375
28MP0002938_white_spotting1.54419705
29MP0003646_muscle_fatigue1.52382021
30MP0005646_abnormal_pituitary_gland1.50408560
31MP0009764_decreased_sensitivity_to1.49303105
32MP0000685_abnormal_immune_system1.49189596
33MP0005645_abnormal_hypothalamus_physiol1.47349773
34MP0004145_abnormal_muscle_electrophysio1.44988557
35MP0008789_abnormal_olfactory_epithelium1.41975685
36MP0003806_abnormal_nucleotide_metabolis1.39454579
37MP0003195_calcinosis1.39060381
38MP0000631_abnormal_neuroendocrine_gland1.38478990
39MP0001919_abnormal_reproductive_system1.37124584
40MP0008007_abnormal_cellular_replicative1.33815967
41MP0008932_abnormal_embryonic_tissue1.30764178
42MP0008872_abnormal_physiological_respon1.28804752
43MP0002095_abnormal_skin_pigmentation1.28559219
44MP0003786_premature_aging1.27402687
45MP0009333_abnormal_splenocyte_physiolog1.26754399
46MP0009379_abnormal_foot_pigmentation1.26551330
47MP0001873_stomach_inflammation1.25024107
48MP0005551_abnormal_eye_electrophysiolog1.23113757
49MP0005389_reproductive_system_phenotype1.22767759
50MP0003137_abnormal_impulse_conducting1.22749981
51MP0009785_altered_susceptibility_to1.21413881
52MP0005084_abnormal_gallbladder_morpholo1.19627298
53MP0003718_maternal_effect1.19090597
54MP0001293_anophthalmia1.17852880
55MP0003111_abnormal_nucleus_morphology1.17519173
56MP0006035_abnormal_mitochondrial_morpho1.15065189
57MP0002277_abnormal_respiratory_mucosa1.11826413
58MP0005253_abnormal_eye_physiology1.11566215
59MP0003937_abnormal_limbs/digits/tail_de1.11448916
60MP0004142_abnormal_muscle_tone1.09883740
61MP0001968_abnormal_touch/_nociception1.09035532
62MP0000015_abnormal_ear_pigmentation1.07978277
63MP0001529_abnormal_vocalization1.02626344
64MP0000049_abnormal_middle_ear1.01304362
65MP0002166_altered_tumor_susceptibility1.00170882
66MP0008875_abnormal_xenobiotic_pharmacok0.99275874
67MP0005499_abnormal_olfactory_system0.97692028
68MP0005394_taste/olfaction_phenotype0.97692028
69MP0001835_abnormal_antigen_presentation0.97689218
70MP0000026_abnormal_inner_ear0.96721285
71MP0002210_abnormal_sex_determination0.95757122
72MP0001853_heart_inflammation0.95577338
73MP0008873_increased_physiological_sensi0.94138398
74MP0001963_abnormal_hearing_physiology0.93825007
75MP0006036_abnormal_mitochondrial_physio0.93746069
76MP0000703_abnormal_thymus_morphology0.92306030
77MP0001929_abnormal_gametogenesis0.91173940
78MP0002282_abnormal_trachea_morphology0.90724372
79MP0002653_abnormal_ependyma_morphology0.87640975
80MP0005423_abnormal_somatic_nervous0.86289449
81MP0001800_abnormal_humoral_immune0.85170816
82MP0009046_muscle_twitch0.83880208
83MP0005174_abnormal_tail_pigmentation0.80380996
84MP0009765_abnormal_xenobiotic_induced0.80049750
85MP0001790_abnormal_immune_system0.79153610
86MP0005387_immune_system_phenotype0.79153610
87MP0001286_abnormal_eye_development0.78471980
88MP0005410_abnormal_fertilization0.77626305
89MP0001119_abnormal_female_reproductive0.76972403
90MP0003943_abnormal_hepatobiliary_system0.76341673
91MP0004885_abnormal_endolymph0.75436693
92MP0005636_abnormal_mineral_homeostasis0.70828456
93MP0001727_abnormal_embryo_implantation0.70420880
94MP0003938_abnormal_ear_development0.69576141
95MP0000689_abnormal_spleen_morphology0.69252519
96MP0000653_abnormal_sex_gland0.68054174
97MP0002098_abnormal_vibrissa_morphology0.66223645
98MP0010368_abnormal_lymphatic_system0.66107630
99MP0003011_delayed_dark_adaptation0.65663364
100MP0006054_spinal_hemorrhage0.64748650

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.28991152
2Colon cancer (HP:0003003)4.26591854
3Aplastic anemia (HP:0001915)4.18473796
4Mitochondrial inheritance (HP:0001427)3.91210076
5Abnormal mitochondria in muscle tissue (HP:0008316)3.80157811
6Increased CSF lactate (HP:0002490)3.77937700
7Oral leukoplakia (HP:0002745)3.68639487
8Increased IgM level (HP:0003496)3.67578500
9Progressive macrocephaly (HP:0004481)3.56694844
10Increased hepatocellular lipid droplets (HP:0006565)3.55559698
11Stomatitis (HP:0010280)3.53698275
12Acute encephalopathy (HP:0006846)3.38731060
13Lipid accumulation in hepatocytes (HP:0006561)3.28925245
14IgG deficiency (HP:0004315)3.19064641
15Abnormality of the prostate (HP:0008775)3.18582172
16Renal Fanconi syndrome (HP:0001994)3.11670200
17Congenital, generalized hypertrichosis (HP:0004540)2.88109937
18Amyotrophic lateral sclerosis (HP:0007354)2.86424312
19Type I transferrin isoform profile (HP:0003642)2.86228270
20Pancytopenia (HP:0001876)2.85703615
21Chromosomal breakage induced by crosslinking agents (HP:0003221)2.82840030
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.78521876
23Cerebral edema (HP:0002181)2.77698142
24Exertional dyspnea (HP:0002875)2.74642456
25Hepatocellular necrosis (HP:0001404)2.68678672
26Stomach cancer (HP:0012126)2.68429109
27Abnormality of midbrain morphology (HP:0002418)2.64515799
28Molar tooth sign on MRI (HP:0002419)2.64515799
29Hypoproteinemia (HP:0003075)2.57761348
30Methylmalonic acidemia (HP:0002912)2.54308907
31Atrophy/Degeneration involving motor neurons (HP:0007373)2.53436556
32Neoplasm of the adrenal cortex (HP:0100641)2.47153897
33Chromsome breakage (HP:0040012)2.45100166
34Leukodystrophy (HP:0002415)2.44583122
35Hepatic necrosis (HP:0002605)2.42819502
36Neoplasm of the adrenal gland (HP:0100631)2.39467372
37Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.38233680
38Increased intramyocellular lipid droplets (HP:0012240)2.35627184
39Hypoplasia of the pons (HP:0012110)2.33071152
403-Methylglutaconic aciduria (HP:0003535)2.31002838
41Abnormal number of erythroid precursors (HP:0012131)2.28794587
42Lethargy (HP:0001254)2.24635851
43Increased serum lactate (HP:0002151)2.23680594
44Abnormality of the pons (HP:0007361)2.20405858
45Respiratory difficulties (HP:0002880)2.18484073
46Pancreatic cysts (HP:0001737)2.12382915
47Abnormality of the ileum (HP:0001549)2.12370011
48Congenital stationary night blindness (HP:0007642)2.10325487
49Amaurosis fugax (HP:0100576)2.09337908
50Abnormality of the labia minora (HP:0012880)2.08626939
51Meckel diverticulum (HP:0002245)2.07140786
52Autoimmune hemolytic anemia (HP:0001890)2.06940385
53Nephronophthisis (HP:0000090)2.05105512
54IgM deficiency (HP:0002850)1.99600363
55Exercise intolerance (HP:0003546)1.98379633
56Abnormality of male internal genitalia (HP:0000022)1.98204102
57Optic disc pallor (HP:0000543)1.94449860
58Abnormal protein N-linked glycosylation (HP:0012347)1.93787914
59Abnormal protein glycosylation (HP:0012346)1.93787914
60Abnormal glycosylation (HP:0012345)1.93787914
61Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93787914
62Increased muscle lipid content (HP:0009058)1.91615078
63Glioma (HP:0009733)1.90411276
64Abnormality of B cell number (HP:0010975)1.88650375
65Abnormality of T cells (HP:0002843)1.87993531
66IgA deficiency (HP:0002720)1.87990361
67Abnormality of T cell physiology (HP:0011840)1.86439575
68Neutropenia (HP:0001875)1.86389159
69Abnormal albumin level (HP:0012116)1.85273946
70Hypoalbuminemia (HP:0003073)1.85273946
71Abnormality of urine glucose concentration (HP:0011016)1.85089294
72Glycosuria (HP:0003076)1.85089294
73Methylmalonic aciduria (HP:0012120)1.83492749
74Cleft eyelid (HP:0000625)1.83405079
75Abnormality of the vitamin B12 metabolism (HP:0004341)1.83282894
76Neoplasm of the colon (HP:0100273)1.82877085
77Pulmonary fibrosis (HP:0002206)1.82456413
78Medial flaring of the eyebrow (HP:0010747)1.82014236
79Abnormal lung lobation (HP:0002101)1.81582958
80Reticulocytopenia (HP:0001896)1.81229331
81Abnormality of methionine metabolism (HP:0010901)1.81068840
82Respiratory failure (HP:0002878)1.80406457
83Aplasia/Hypoplasia of the uvula (HP:0010293)1.78892674
84Cellular immunodeficiency (HP:0005374)1.78551562
85Lactic acidosis (HP:0003128)1.78345633
86Pendular nystagmus (HP:0012043)1.78096267
87Abnormality of cells of the erythroid lineage (HP:0012130)1.77894921
88Pigmentary retinal degeneration (HP:0001146)1.77415094
89Septo-optic dysplasia (HP:0100842)1.77346651
90Hyperphosphaturia (HP:0003109)1.76376128
91Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.75274735
92Adactyly (HP:0009776)1.73938665
93Type II lissencephaly (HP:0007260)1.73914279
94Abnormality of the nasal septum (HP:0000419)1.73403049
95Ureteral stenosis (HP:0000071)1.73311174
96Abnormal hair whorl (HP:0010721)1.71648750
97Sparse eyelashes (HP:0000653)1.71514942
98Abnormality of vitamin B metabolism (HP:0004340)1.70495128
99Tinnitus (HP:0000360)1.68851501
100Severe combined immunodeficiency (HP:0004430)1.68087677

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.51553484
2ZAK5.18437504
3TXK4.67579501
4BRSK23.95896502
5BUB13.57200669
6NUAK13.42625536
7WEE12.82420097
8TAF12.74660906
9MST42.70259124
10VRK12.67061368
11PLK32.22489832
12KDR2.07677999
13DYRK21.96994633
14BMPR1B1.92420650
15TTK1.66486176
16BRSK11.62958928
17WNK31.52287152
18CDC71.52151173
19SRPK11.45987236
20NEK11.45051657
21TRIM281.42575586
22CHEK21.37508563
23ADRBK21.33456186
24MAP3K121.28523954
25TLK11.15050867
26PLK41.15042497
27EIF2AK21.10674969
28MKNK21.04805284
29TSSK61.02910338
30NEK20.97461992
31MUSK0.97114588
32MAP3K40.93649847
33MAP2K70.92678784
34GRK10.92150625
35LATS10.89803270
36OXSR10.89198715
37NME10.88980592
38PLK10.88826136
39PASK0.83230144
40SMG10.83227866
41TNIK0.80407100
42EIF2AK30.80159761
43GRK50.79345344
44AURKB0.76681610
45MARK30.75505813
46FRK0.74703029
47PDK20.69395664
48BCR0.69022609
49DAPK10.67390840
50CCNB10.66098657
51MAPKAPK50.64362738
52TESK20.64058143
53DAPK30.61189383
54NLK0.57637419
55PKN10.56314487
56CSNK1A1L0.55898986
57ATR0.54796739
58STK40.53366353
59MKNK10.53218665
60PLK20.52372978
61PBK0.51267587
62DAPK20.49871399
63CDK190.49661674
64STK390.48325651
65CSNK1G30.45789165
66MYLK0.43601742
67STK30.42607093
68ITK0.42448741
69MELK0.39382101
70IKBKB0.39309425
71CDK60.39122806
72TNK20.39014095
73PRKCG0.38847531
74ADRBK10.38302400
75ACVR1B0.37832032
76PRKCQ0.36123823
77WNK40.35571798
78CSNK1G10.33429718
79PNCK0.32130184
80CSNK2A10.31827131
81UHMK10.31820065
82TYRO30.31681316
83IKBKE0.31659114
84EIF2AK10.30542145
85FGFR10.30346194
86AURKA0.28963062
87IGF1R0.27567075
88RPS6KA50.27272829
89STK160.26459126
90INSRR0.24735434
91FLT30.24325100
92TAOK30.24218446
93ATM0.23928465
94EPHB20.22400269
95TIE10.21308123
96GRK70.20598525
97IRAK10.20584734
98CHUK0.20127112
99IRAK20.19707615
100MAPK130.17807171

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.95668247
2Oxidative phosphorylation_Homo sapiens_hsa001903.74994104
3Parkinsons disease_Homo sapiens_hsa050123.10532662
4Protein export_Homo sapiens_hsa030603.07432324
5Primary immunodeficiency_Homo sapiens_hsa053402.90355845
6RNA polymerase_Homo sapiens_hsa030202.78802311
7Mismatch repair_Homo sapiens_hsa034302.49085163
8Ribosome_Homo sapiens_hsa030102.35572573
9Homologous recombination_Homo sapiens_hsa034402.21993641
10DNA replication_Homo sapiens_hsa030302.20520034
11Huntingtons disease_Homo sapiens_hsa050162.16229090
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07538350
13Alzheimers disease_Homo sapiens_hsa050102.03812196
14Spliceosome_Homo sapiens_hsa030401.89102783
15RNA degradation_Homo sapiens_hsa030181.86523895
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.81012646
17Non-homologous end-joining_Homo sapiens_hsa034501.75964077
18Autoimmune thyroid disease_Homo sapiens_hsa053201.70249340
19Base excision repair_Homo sapiens_hsa034101.70108735
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.60430795
21RNA transport_Homo sapiens_hsa030131.55481669
22Basal transcription factors_Homo sapiens_hsa030221.54361867
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50331696
24Fanconi anemia pathway_Homo sapiens_hsa034601.45563242
25Pyrimidine metabolism_Homo sapiens_hsa002401.44429781
26Nucleotide excision repair_Homo sapiens_hsa034201.42616968
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34833300
28Systemic lupus erythematosus_Homo sapiens_hsa053221.33770446
29Cell cycle_Homo sapiens_hsa041101.33444477
30One carbon pool by folate_Homo sapiens_hsa006701.32781555
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.30470041
32Allograft rejection_Homo sapiens_hsa053301.29069193
33p53 signaling pathway_Homo sapiens_hsa041151.27210094
34Glutathione metabolism_Homo sapiens_hsa004801.25235502
35Phototransduction_Homo sapiens_hsa047441.16855363
36Purine metabolism_Homo sapiens_hsa002301.07087600
37Graft-versus-host disease_Homo sapiens_hsa053321.03347477
38Asthma_Homo sapiens_hsa053100.99018571
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.99012251
40Nitrogen metabolism_Homo sapiens_hsa009100.98030174
41Cardiac muscle contraction_Homo sapiens_hsa042600.95840736
42Shigellosis_Homo sapiens_hsa051310.92698047
43Propanoate metabolism_Homo sapiens_hsa006400.91952269
44Vitamin digestion and absorption_Homo sapiens_hsa049770.90896136
45Antigen processing and presentation_Homo sapiens_hsa046120.90291009
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90160188
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.89588881
48Pyruvate metabolism_Homo sapiens_hsa006200.83286867
49Rheumatoid arthritis_Homo sapiens_hsa053230.82921513
50Butanoate metabolism_Homo sapiens_hsa006500.82825443
51Collecting duct acid secretion_Homo sapiens_hsa049660.76981568
52Hedgehog signaling pathway_Homo sapiens_hsa043400.75515231
53Steroid biosynthesis_Homo sapiens_hsa001000.74402424
54Folate biosynthesis_Homo sapiens_hsa007900.73869897
55Hematopoietic cell lineage_Homo sapiens_hsa046400.73235499
56Epstein-Barr virus infection_Homo sapiens_hsa051690.72722823
57T cell receptor signaling pathway_Homo sapiens_hsa046600.70932013
58Oocyte meiosis_Homo sapiens_hsa041140.68575498
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67451803
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66757053
61Type I diabetes mellitus_Homo sapiens_hsa049400.63019492
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62131199
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61768464
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59649867
65Caffeine metabolism_Homo sapiens_hsa002320.59546768
66Selenocompound metabolism_Homo sapiens_hsa004500.56043340
67Olfactory transduction_Homo sapiens_hsa047400.55745704
68Metabolic pathways_Homo sapiens_hsa011000.55539530
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55336049
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53564476
71Peroxisome_Homo sapiens_hsa041460.53022754
72Vitamin B6 metabolism_Homo sapiens_hsa007500.52269440
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50438388
74N-Glycan biosynthesis_Homo sapiens_hsa005100.49667340
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49558450
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48947056
77Tryptophan metabolism_Homo sapiens_hsa003800.48220457
78Sulfur metabolism_Homo sapiens_hsa009200.47836872
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47760640
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46820362
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46644644
82Linoleic acid metabolism_Homo sapiens_hsa005910.46052110
83Chemical carcinogenesis_Homo sapiens_hsa052040.44901171
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44736596
85Alcoholism_Homo sapiens_hsa050340.43593204
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40813021
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38936130
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36338835
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35320537
90Legionellosis_Homo sapiens_hsa051340.34460077
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33211699
92Measles_Homo sapiens_hsa051620.31239018
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30964335
94Malaria_Homo sapiens_hsa051440.28116069
95Sulfur relay system_Homo sapiens_hsa041220.26779454
96Viral myocarditis_Homo sapiens_hsa054160.25889120
97Viral carcinogenesis_Homo sapiens_hsa052030.23375981
98beta-Alanine metabolism_Homo sapiens_hsa004100.22040328
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22003350
100Regulation of autophagy_Homo sapiens_hsa041400.21242876

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