H2AFZP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.35628760
2proteasome assembly (GO:0043248)6.19928188
3somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)5.16152796
4somatic diversification of immunoglobulins involved in immune response (GO:0002208)5.16152796
5isotype switching (GO:0045190)5.16152796
6regulation of mitotic spindle checkpoint (GO:1903504)4.42312386
7regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.42312386
8rRNA modification (GO:0000154)4.30236477
9ATP synthesis coupled proton transport (GO:0015986)4.16024593
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.16024593
11protein neddylation (GO:0045116)4.08031443
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.02124982
13cytidine metabolic process (GO:0046087)3.95635911
14cytidine catabolic process (GO:0006216)3.95635911
15cytidine deamination (GO:0009972)3.95635911
16regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.86625512
17rRNA methylation (GO:0031167)3.81355218
18maturation of 5.8S rRNA (GO:0000460)3.78731286
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.78498529
20piRNA metabolic process (GO:0034587)3.67794260
21water-soluble vitamin biosynthetic process (GO:0042364)3.62508144
22protein complex biogenesis (GO:0070271)3.62287733
23establishment of protein localization to mitochondrial membrane (GO:0090151)3.59403790
24regulation of cellular amino acid metabolic process (GO:0006521)3.55726213
25somatic recombination of immunoglobulin gene segments (GO:0016447)3.50408591
26protein-cofactor linkage (GO:0018065)3.48252605
27pseudouridine synthesis (GO:0001522)3.46391405
28mitochondrial respiratory chain complex assembly (GO:0033108)3.45496611
29electron transport chain (GO:0022900)3.44356302
30respiratory electron transport chain (GO:0022904)3.43282597
31pyrimidine ribonucleoside catabolic process (GO:0046133)3.42761176
32somatic diversification of immunoglobulins (GO:0016445)3.41967096
33RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.41460608
34tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.41460608
35chaperone-mediated protein transport (GO:0072321)3.39125708
36NADH dehydrogenase complex assembly (GO:0010257)3.38250385
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.38250385
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.38250385
39DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.36796054
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.35126177
41exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.31848826
42rRNA catabolic process (GO:0016075)3.31179723
43signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.30599874
44signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.30599874
45signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.30599874
46signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.25994283
47intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.25994283
48nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.25684806
49positive regulation of T cell migration (GO:2000406)3.24360756
50interferon-gamma production (GO:0032609)3.23137495
51respiratory chain complex IV assembly (GO:0008535)3.18236752
52S-adenosylmethionine metabolic process (GO:0046500)3.16580044
53synapsis (GO:0007129)3.16203394
54L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.14834300
55signal transduction involved in DNA damage checkpoint (GO:0072422)3.13984678
56signal transduction involved in DNA integrity checkpoint (GO:0072401)3.13984678
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.13523503
58signal transduction involved in cell cycle checkpoint (GO:0072395)3.12465213
59cytochrome complex assembly (GO:0017004)3.07139726
60protein deneddylation (GO:0000338)3.07120910
61regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.04547063
62cullin deneddylation (GO:0010388)3.04388671
63negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.03175715
64negative regulation of ligase activity (GO:0051352)3.03175715
65RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.99141780
66regulation of immunoglobulin secretion (GO:0051023)2.95025389
67termination of RNA polymerase III transcription (GO:0006386)2.93257530
68transcription elongation from RNA polymerase III promoter (GO:0006385)2.93257530
69positive regulation of prostaglandin secretion (GO:0032308)2.90583989
70DNA catabolic process, exonucleolytic (GO:0000738)2.86744177
71chromatin remodeling at centromere (GO:0031055)2.86630786
72GTP biosynthetic process (GO:0006183)2.85360499
73regulation of mitochondrial translation (GO:0070129)2.82598216
74anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.79675517
75rRNA processing (GO:0006364)2.78172210
76behavioral response to nicotine (GO:0035095)2.77717744
77detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.76726000
78protein targeting to mitochondrion (GO:0006626)2.76369905
79positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.75988485
80rRNA metabolic process (GO:0016072)2.75838730
81somatic diversification of immune receptors (GO:0002200)2.75098465
82somatic cell DNA recombination (GO:0016444)2.74902965
83somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.74902965
84L-methionine salvage (GO:0071267)2.71550440
85L-methionine biosynthetic process (GO:0071265)2.71550440
86amino acid salvage (GO:0043102)2.71550440
87regulation of T cell migration (GO:2000404)2.70858099
88somatic hypermutation of immunoglobulin genes (GO:0016446)2.69099185
89somatic diversification of immune receptors via somatic mutation (GO:0002566)2.69099185
90DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.68585604
91ribosomal small subunit assembly (GO:0000028)2.68469120
92positive regulation of lymphocyte migration (GO:2000403)2.67637172
93ribosome biogenesis (GO:0042254)2.66291297
94cellular ketone body metabolic process (GO:0046950)2.65163176
95inner mitochondrial membrane organization (GO:0007007)2.64502472
96positive regulation of ligase activity (GO:0051351)2.62329178
97ubiquinone biosynthetic process (GO:0006744)2.59909991
98CENP-A containing nucleosome assembly (GO:0034080)2.59843633
99establishment of protein localization to mitochondrion (GO:0072655)2.59692208
100B cell activation involved in immune response (GO:0002312)2.59364691

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.48455094
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.30703777
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.56608407
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.43198807
5VDR_22108803_ChIP-Seq_LS180_Human3.20500418
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.04423440
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.86809073
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.82178577
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.70497026
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57731293
11ELK1_19687146_ChIP-ChIP_HELA_Human2.49238289
12VDR_23849224_ChIP-Seq_CD4+_Human2.37920225
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.37522734
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.37059720
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.29932839
16ZNF274_21170338_ChIP-Seq_K562_Hela2.24606264
17E2F7_22180533_ChIP-Seq_HELA_Human2.17245379
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.07252734
19FOXP3_21729870_ChIP-Seq_TREG_Human1.98022402
20SRF_21415370_ChIP-Seq_HL-1_Mouse1.95393716
21PCGF2_27294783_Chip-Seq_NPCs_Mouse1.91900731
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89363207
23EZH2_22144423_ChIP-Seq_EOC_Human1.86727785
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85847309
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83866167
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.83812369
27MYC_18940864_ChIP-ChIP_HL60_Human1.80026285
28TP53_22573176_ChIP-Seq_HFKS_Human1.79928580
29EWS_26573619_Chip-Seq_HEK293_Human1.74781152
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72661968
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.72075549
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67357101
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65122683
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.54410563
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49800054
36GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.46798140
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44697122
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43934356
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36095208
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.34629639
41FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32670197
42FOXA1_25329375_ChIP-Seq_VCAP_Human1.32670197
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31088249
44IRF1_19129219_ChIP-ChIP_H3396_Human1.29681440
45GATA3_26560356_Chip-Seq_TH2_Human1.29503094
46GATA3_21878914_ChIP-Seq_MCF-7_Human1.29382155
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.27158018
48DCP1A_22483619_ChIP-Seq_HELA_Human1.26012903
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.26003355
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25041735
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24938097
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.22342470
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.21309681
54IGF1R_20145208_ChIP-Seq_DFB_Human1.20595406
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20242380
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18349960
57IRF8_22096565_ChIP-ChIP_GC-B_Human1.17671740
58ER_23166858_ChIP-Seq_MCF-7_Human1.16534504
59PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16027095
60AR_20517297_ChIP-Seq_VCAP_Human1.15739363
61AUTS2_25519132_ChIP-Seq_293T-REX_Human1.15402037
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15331176
63NCOR_22424771_ChIP-Seq_293T_Human1.12137324
64FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12010241
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.12002683
66NANOG_19829295_ChIP-Seq_ESCs_Human1.11581469
67SOX2_19829295_ChIP-Seq_ESCs_Human1.11581469
68HOXB7_26014856_ChIP-Seq_BT474_Human1.10452702
69TTF2_22483619_ChIP-Seq_HELA_Human1.09610984
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08647748
71FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07245177
72P300_19829295_ChIP-Seq_ESCs_Human1.05188276
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04987139
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.04952691
75ERG_20517297_ChIP-Seq_VCAP_Human1.04415791
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04191948
77FOXH1_21741376_ChIP-Seq_EPCs_Human1.01170037
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01140023
79FUS_26573619_Chip-Seq_HEK293_Human0.99445113
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99029351
81GABP_19822575_ChIP-Seq_HepG2_Human0.98651789
82TCF4_22108803_ChIP-Seq_LS180_Human0.98398710
83ELK1_22589737_ChIP-Seq_MCF10A_Human0.97436626
84RBPJ_21746931_ChIP-Seq_IB4_Human0.97357610
85GBX2_23144817_ChIP-Seq_PC3_Human0.96166967
86MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95100891
87E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92543948
88PHF8_20622853_ChIP-Seq_HELA_Human0.91773058
89MYC_19829295_ChIP-Seq_ESCs_Human0.91506676
90GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.90891284
91EGR1_23403033_ChIP-Seq_LIVER_Mouse0.90657029
92TDRD3_21172665_ChIP-Seq_MCF-7_Human0.89867015
93GATA6_21074721_ChIP-Seq_CACO-2_Human0.89852232
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89734141
95HTT_18923047_ChIP-ChIP_STHdh_Human0.88097113
96PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87122106
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85243229
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.85109176
99TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84657173
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84418875

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.50054918
2MP0002138_abnormal_hepatobiliary_system3.46872795
3MP0008877_abnormal_DNA_methylation3.45598466
4MP0005645_abnormal_hypothalamus_physiol3.28758735
5MP0004147_increased_porphyrin_level2.87232837
6MP0008058_abnormal_DNA_repair2.68479162
7MP0001968_abnormal_touch/_nociception2.49385698
8MP0005084_abnormal_gallbladder_morpholo2.45223669
9MP0008875_abnormal_xenobiotic_pharmacok2.43096761
10MP0005671_abnormal_response_to2.39076297
11MP0003787_abnormal_imprinting2.36816384
12MP0005075_abnormal_melanosome_morpholog2.34658284
13MP0001835_abnormal_antigen_presentation2.09824718
14MP0010094_abnormal_chromosome_stability2.09425158
15MP0000685_abnormal_immune_system2.05525454
16MP0006036_abnormal_mitochondrial_physio1.97645410
17MP0002163_abnormal_gland_morphology1.95751203
18MP0003806_abnormal_nucleotide_metabolis1.91909993
19MP0005646_abnormal_pituitary_gland1.90233323
20MP0003786_premature_aging1.73915780
21MP0005389_reproductive_system_phenotype1.68652829
22MP0003195_calcinosis1.64565837
23MP0008872_abnormal_physiological_respon1.61979638
24MP0002736_abnormal_nociception_after1.59428750
25MP0004885_abnormal_endolymph1.57096395
26MP0008007_abnormal_cellular_replicative1.53154599
27MP0002160_abnormal_reproductive_system1.52814172
28MP0002837_dystrophic_cardiac_calcinosis1.52380642
29MP0001188_hyperpigmentation1.51775124
30MP0005174_abnormal_tail_pigmentation1.49776383
31MP0009333_abnormal_splenocyte_physiolog1.47147486
32MP0000372_irregular_coat_pigmentation1.46389843
33MP0006072_abnormal_retinal_apoptosis1.44794071
34MP0004145_abnormal_muscle_electrophysio1.44649487
35MP0001986_abnormal_taste_sensitivity1.43843253
36MP0003136_yellow_coat_color1.41923032
37MP0005551_abnormal_eye_electrophysiolog1.41216950
38MP0006035_abnormal_mitochondrial_morpho1.41099346
39MP0000015_abnormal_ear_pigmentation1.39288368
40MP0008789_abnormal_olfactory_epithelium1.37594014
41MP0003646_muscle_fatigue1.28164009
42MP0005379_endocrine/exocrine_gland_phen1.26721290
43MP0003718_maternal_effect1.24620424
44MP0001529_abnormal_vocalization1.23589506
45MP0002095_abnormal_skin_pigmentation1.21629470
46MP0004215_abnormal_myocardial_fiber1.19719480
47MP0005410_abnormal_fertilization1.18279812
48MP0002272_abnormal_nervous_system1.17233277
49MP0006276_abnormal_autonomic_nervous1.15558910
50MP0006292_abnormal_olfactory_placode1.15390938
51MP0002277_abnormal_respiratory_mucosa1.15140645
52MP0001919_abnormal_reproductive_system1.14563020
53MP0003011_delayed_dark_adaptation1.09491588
54MP0003693_abnormal_embryo_hatching1.09487942
55MP0010386_abnormal_urinary_bladder1.06992997
56MP0001800_abnormal_humoral_immune1.05631920
57MP0009046_muscle_twitch1.04527968
58MP0002210_abnormal_sex_determination1.02631467
59MP0004381_abnormal_hair_follicle1.00825687
60MP0001929_abnormal_gametogenesis0.99953355
61MP0002733_abnormal_thermal_nociception0.97527599
62MP0004957_abnormal_blastocyst_morpholog0.96727853
63MP0003763_abnormal_thymus_physiology0.95813776
64MP0005387_immune_system_phenotype0.94365888
65MP0001790_abnormal_immune_system0.94365888
66MP0002148_abnormal_hypersensitivity_rea0.93402030
67MP0009745_abnormal_behavioral_response0.91347424
68MP0003137_abnormal_impulse_conducting0.90166517
69MP0005636_abnormal_mineral_homeostasis0.87467171
70MP0001905_abnormal_dopamine_level0.87155782
71MP0003121_genomic_imprinting0.86204477
72MP0003567_abnormal_fetal_cardiomyocyte0.83414498
73MP0003252_abnormal_bile_duct0.81710046
74MP0001764_abnormal_homeostasis0.81113525
75MP0000689_abnormal_spleen_morphology0.80571524
76MP0005000_abnormal_immune_tolerance0.80364743
77MP0000653_abnormal_sex_gland0.78766064
78MP0004142_abnormal_muscle_tone0.78423795
79MP0001145_abnormal_male_reproductive0.77837908
80MP0002420_abnormal_adaptive_immunity0.77443470
81MP0003045_fibrosis0.75951604
82MP0001819_abnormal_immune_cell0.75683404
83MP0001542_abnormal_bone_strength0.75310566
84MP0002452_abnormal_antigen_presenting0.74890293
85MP0001119_abnormal_female_reproductive0.74621159
86MP0001970_abnormal_pain_threshold0.74393394
87MP0005167_abnormal_blood-brain_barrier0.73094358
88MP0002229_neurodegeneration0.72102706
89MP0002723_abnormal_immune_serum0.71311690
90MP0000013_abnormal_adipose_tissue0.70226996
91MP0002938_white_spotting0.68847396
92MP0003111_abnormal_nucleus_morphology0.68684768
93MP0002166_altered_tumor_susceptibility0.68107230
94MP0009384_cardiac_valve_regurgitation0.67928519
95MP0005253_abnormal_eye_physiology0.67262215
96MP0009697_abnormal_copulation0.65068388
97MP0005394_taste/olfaction_phenotype0.65049793
98MP0005499_abnormal_olfactory_system0.65049793
99MP0002019_abnormal_tumor_incidence0.64308068
100MP0002398_abnormal_bone_marrow0.63053859

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)6.03225061
2Acute necrotizing encephalopathy (HP:0006965)4.33484011
3Increased IgM level (HP:0003496)4.12366139
4Abnormal mitochondria in muscle tissue (HP:0008316)3.91951074
5IgG deficiency (HP:0004315)3.80656410
6Mitochondrial inheritance (HP:0001427)3.73355909
7Progressive macrocephaly (HP:0004481)3.67359632
8Increased CSF lactate (HP:0002490)3.62962514
9Acute encephalopathy (HP:0006846)3.62691734
10Congenital stationary night blindness (HP:0007642)3.34786257
11Abnormality of T cell physiology (HP:0011840)3.01837833
12Abnormality of alanine metabolism (HP:0010916)2.99178762
13Hyperalaninemia (HP:0003348)2.99178762
14Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.99178762
15Type 2 muscle fiber atrophy (HP:0003554)2.99160739
163-Methylglutaconic aciduria (HP:0003535)2.95058425
17Methylmalonic aciduria (HP:0012120)2.89442301
18Hepatocellular necrosis (HP:0001404)2.88298436
19Abnormal rod and cone electroretinograms (HP:0008323)2.87287621
20Methylmalonic acidemia (HP:0002912)2.87216769
21Congenital, generalized hypertrichosis (HP:0004540)2.81314213
22Pancreatic cysts (HP:0001737)2.81003827
23Colon cancer (HP:0003003)2.75462455
24Hepatic necrosis (HP:0002605)2.75085994
25Abnormality of the prostate (HP:0008775)2.74626694
26Absent rod-and cone-mediated responses on ERG (HP:0007688)2.73508944
27Cerebral edema (HP:0002181)2.72914674
28Polydipsia (HP:0001959)2.67570664
29Abnormal drinking behavior (HP:0030082)2.67570664
30Renal cortical cysts (HP:0000803)2.65735636
31IgA deficiency (HP:0002720)2.65592895
32Decreased circulating renin level (HP:0003351)2.65388472
33Pancreatic fibrosis (HP:0100732)2.61999701
34Increased hepatocellular lipid droplets (HP:0006565)2.53698282
35Optic disc pallor (HP:0000543)2.49272761
36Abnormality of the labia minora (HP:0012880)2.46601205
37Multiple enchondromatosis (HP:0005701)2.37337634
38Increased serum lactate (HP:0002151)2.36980193
39True hermaphroditism (HP:0010459)2.36497325
40Aplastic anemia (HP:0001915)2.35294305
41Lethargy (HP:0001254)2.34713870
42Abnormality of the renal cortex (HP:0011035)2.33915272
43Abnormality of T cells (HP:0002843)2.33626574
44Lipid accumulation in hepatocytes (HP:0006561)2.32780100
45Type II lissencephaly (HP:0007260)2.31167250
46Muscle fiber atrophy (HP:0100295)2.29541984
47Polyuria (HP:0000103)2.26301594
48Abnormality of DNA repair (HP:0003254)2.25395522
49Lactic acidosis (HP:0003128)2.20673465
50Abnormality of midbrain morphology (HP:0002418)2.17157503
51Molar tooth sign on MRI (HP:0002419)2.17157503
52Abnormality of male internal genitalia (HP:0000022)2.13459752
53Short tibia (HP:0005736)2.12254182
54Progressive microcephaly (HP:0000253)2.09287400
55Respiratory failure (HP:0002878)2.08195778
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.07931517
57Dicarboxylic aciduria (HP:0003215)2.07931517
58Oral leukoplakia (HP:0002745)2.07410931
59Increased intramyocellular lipid droplets (HP:0012240)2.06970705
60Neutropenia (HP:0001875)2.06459386
61Attenuation of retinal blood vessels (HP:0007843)2.05533039
62Decreased central vision (HP:0007663)2.05382715
63Abnormality of B cell number (HP:0010975)2.05031049
64Pancytopenia (HP:0001876)2.04697786
65Exertional dyspnea (HP:0002875)2.03549301
66Aplasia/hypoplasia of the uterus (HP:0008684)2.03446317
67Decreased electroretinogram (ERG) amplitude (HP:0000654)2.00411711
68Aplasia/Hypoplasia of the tibia (HP:0005772)1.99044973
69Aplasia/Hypoplasia of the tongue (HP:0010295)1.95674762
70Prostate neoplasm (HP:0100787)1.94431065
71Elevated erythrocyte sedimentation rate (HP:0003565)1.92770606
72Mesangial abnormality (HP:0001966)1.92738697
73Abolished electroretinogram (ERG) (HP:0000550)1.92566870
74Leukodystrophy (HP:0002415)1.90610740
75Pendular nystagmus (HP:0012043)1.90285729
76Nephronophthisis (HP:0000090)1.86692252
77Ketosis (HP:0001946)1.81232436
78Tinnitus (HP:0000360)1.80900998
79Abnormal urine output (HP:0012590)1.79707875
80Aplasia/Hypoplasia of the fovea (HP:0008060)1.78769527
81Hypoplasia of the fovea (HP:0007750)1.78769527
82Cleft eyelid (HP:0000625)1.78476507
83Severe combined immunodeficiency (HP:0004430)1.78152462
84Abnormality of homocysteine metabolism (HP:0010919)1.78036159
85Homocystinuria (HP:0002156)1.78036159
86Limb dystonia (HP:0002451)1.77651514
87Abnormality of serum amino acid levels (HP:0003112)1.77122215
88Hypoplasia of the uterus (HP:0000013)1.76984446
89Renal Fanconi syndrome (HP:0001994)1.76381102
90Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76348827
91Respiratory difficulties (HP:0002880)1.74905947
92Cerebellar dysplasia (HP:0007033)1.72149719
93Supernumerary spleens (HP:0009799)1.70836101
94Hyperglycinemia (HP:0002154)1.70716383
95Aplasia/Hypoplasia of the spleen (HP:0010451)1.69157466
96B lymphocytopenia (HP:0010976)1.68341537
97Abnormality of aspartate family amino acid metabolism (HP:0010899)1.68094823
98Asplenia (HP:0001746)1.68060773
99Abnormality of renin-angiotensin system (HP:0000847)1.67816899
100Central scotoma (HP:0000603)1.65877953

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.37248944
2NUAK13.69442903
3TXK3.54835811
4VRK23.16015122
5ADRBK22.36119473
6TAOK32.29864463
7ZAK2.29810751
8EIF2AK32.29311871
9GRK12.28832855
10BUB12.22073069
11EIF2AK12.15776611
12NEK12.06635805
13WNK42.03065526
14PDK22.00018192
15VRK11.99469254
16TLK11.89938723
17BMPR1B1.82809957
18OXSR11.81844092
19FRK1.79197528
20PLK41.78694130
21STK391.77459351
22MKNK21.66345690
23KDR1.56789947
24MKNK11.53699471
25TESK21.53365774
26WNK31.49966534
27PLK31.41833574
28EIF2AK21.37108869
29MST41.36481325
30CSNK1G31.16406873
31DAPK11.15967958
32GRK51.13848764
33TSSK61.12161442
34MAP4K21.08516679
35IKBKB1.05663113
36CSNK1G11.02578366
37GRK71.00673587
38PLK20.98609480
39CCNB10.95779112
40BRSK20.95420454
41SRPK10.94489440
42DYRK20.89849273
43NME10.88382588
44TAF10.88215291
45PHKG10.86824460
46PHKG20.86824460
47KIT0.86480386
48MAPKAPK50.85208399
49CSNK1A1L0.84984077
50CSNK1G20.82745325
51BCKDK0.82718983
52SYK0.77481522
53DAPK20.75167277
54WEE10.74992613
55PRKCQ0.74961236
56TGFBR20.74927961
57TIE10.73098654
58ADRBK10.70481856
59ITK0.70404439
60RPS6KA50.70318105
61MAPK130.69278363
62INSRR0.69252468
63PRKCG0.67386299
64CDC70.60482310
65TTK0.58071636
66PLK10.57622513
67ACVR1B0.55641783
68IKBKE0.53472175
69ATR0.51009014
70TEC0.49998313
71IGF1R0.47873261
72LIMK10.47399855
73TESK10.46239750
74AURKB0.44587285
75LCK0.42477753
76BMPR20.41949415
77CAMKK20.40840025
78CSNK1A10.39539482
79PRKCI0.39390562
80PINK10.38654718
81PRKACA0.37723333
82PRKCE0.36973730
83CSNK2A10.36457724
84MAP2K20.36068055
85CSNK2A20.35477249
86OBSCN0.35341680
87NTRK30.34591857
88ALK0.34213510
89CHEK20.33315987
90RAF10.33244133
91CSNK1D0.32720875
92MINK10.32384034
93LYN0.31749447
94ATM0.31040924
95MAPKAPK30.29356792
96PRKCD0.29059835
97ABL10.28991919
98CDK30.28058255
99TNK20.27999125
100MUSK0.27746641

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.33968684
2Oxidative phosphorylation_Homo sapiens_hsa001903.24181283
3Vitamin B6 metabolism_Homo sapiens_hsa007502.97676826
4Primary immunodeficiency_Homo sapiens_hsa053402.87471167
5Parkinsons disease_Homo sapiens_hsa050122.87149294
6Protein export_Homo sapiens_hsa030602.61672901
7Ribosome_Homo sapiens_hsa030102.51187068
8Mismatch repair_Homo sapiens_hsa034302.31655160
9One carbon pool by folate_Homo sapiens_hsa006702.29399315
10Homologous recombination_Homo sapiens_hsa034402.25070806
11Asthma_Homo sapiens_hsa053102.20236447
12DNA replication_Homo sapiens_hsa030302.13437433
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.12271124
14RNA polymerase_Homo sapiens_hsa030202.01651507
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.99429936
16Autoimmune thyroid disease_Homo sapiens_hsa053201.92480337
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.91346141
18Allograft rejection_Homo sapiens_hsa053301.82518876
19Nucleotide excision repair_Homo sapiens_hsa034201.78849550
20Alzheimers disease_Homo sapiens_hsa050101.78610652
21Phototransduction_Homo sapiens_hsa047441.77095837
22Huntingtons disease_Homo sapiens_hsa050161.74338066
23Basal transcription factors_Homo sapiens_hsa030221.71980412
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70409802
25RNA degradation_Homo sapiens_hsa030181.60698083
26Fanconi anemia pathway_Homo sapiens_hsa034601.51595279
27Linoleic acid metabolism_Homo sapiens_hsa005911.50589883
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.45093103
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39104404
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36748853
31Nitrogen metabolism_Homo sapiens_hsa009101.35678520
32Caffeine metabolism_Homo sapiens_hsa002321.34844128
33Cardiac muscle contraction_Homo sapiens_hsa042601.34569157
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33909816
35RNA transport_Homo sapiens_hsa030131.28321277
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28286649
37Base excision repair_Homo sapiens_hsa034101.27986190
38Propanoate metabolism_Homo sapiens_hsa006401.13127536
39Non-homologous end-joining_Homo sapiens_hsa034501.10599118
40Graft-versus-host disease_Homo sapiens_hsa053321.08533647
41Purine metabolism_Homo sapiens_hsa002301.06316492
42Rheumatoid arthritis_Homo sapiens_hsa053231.04794756
43Peroxisome_Homo sapiens_hsa041461.04236706
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02464484
45Butanoate metabolism_Homo sapiens_hsa006501.02376573
46Pyrimidine metabolism_Homo sapiens_hsa002401.01667265
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95305955
48Spliceosome_Homo sapiens_hsa030400.94648368
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92419814
50Tryptophan metabolism_Homo sapiens_hsa003800.89292302
51Antigen processing and presentation_Homo sapiens_hsa046120.85843521
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84671702
53Type I diabetes mellitus_Homo sapiens_hsa049400.83227870
54Folate biosynthesis_Homo sapiens_hsa007900.79745884
55Fatty acid elongation_Homo sapiens_hsa000620.73561753
56Ether lipid metabolism_Homo sapiens_hsa005650.72415248
57Pyruvate metabolism_Homo sapiens_hsa006200.72324764
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.71933132
59Olfactory transduction_Homo sapiens_hsa047400.71810066
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71076350
61Collecting duct acid secretion_Homo sapiens_hsa049660.69489687
62Chemical carcinogenesis_Homo sapiens_hsa052040.67409939
63Retinol metabolism_Homo sapiens_hsa008300.66379679
64Arachidonic acid metabolism_Homo sapiens_hsa005900.65780564
65Sulfur metabolism_Homo sapiens_hsa009200.65181900
66Viral myocarditis_Homo sapiens_hsa054160.60900329
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59832816
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59705644
69Metabolic pathways_Homo sapiens_hsa011000.59385227
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.59003546
71Fatty acid degradation_Homo sapiens_hsa000710.58042695
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56420126
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53611720
74Vitamin digestion and absorption_Homo sapiens_hsa049770.51348618
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50763608
76T cell receptor signaling pathway_Homo sapiens_hsa046600.48377846
77Fatty acid metabolism_Homo sapiens_hsa012120.46472714
78Systemic lupus erythematosus_Homo sapiens_hsa053220.46340412
79Nicotine addiction_Homo sapiens_hsa050330.44838317
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42757833
81Taste transduction_Homo sapiens_hsa047420.41567857
82Hematopoietic cell lineage_Homo sapiens_hsa046400.39783107
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38941661
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.38191884
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37481131
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.36049740
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34912662
88p53 signaling pathway_Homo sapiens_hsa041150.34149857
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31922780
90Morphine addiction_Homo sapiens_hsa050320.31363257
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30084157
92beta-Alanine metabolism_Homo sapiens_hsa004100.29610602
93Serotonergic synapse_Homo sapiens_hsa047260.28861894
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28153763
95Fat digestion and absorption_Homo sapiens_hsa049750.28111282
96Selenocompound metabolism_Homo sapiens_hsa004500.27916490
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26259668
98Ovarian steroidogenesis_Homo sapiens_hsa049130.26158595
99Steroid biosynthesis_Homo sapiens_hsa001000.25937430
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24160875

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