H2AFZP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of T cell receptor signaling pathway (GO:0050860)7.46004146
2multicellular organismal reproductive behavior (GO:0033057)6.73607506
3negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)6.20893093
4meiotic chromosome segregation (GO:0045132)5.75001960
5protein-chromophore linkage (GO:0018298)5.41281274
6phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)5.21691592
7relaxation of smooth muscle (GO:0044557)5.09130960
8DNA deamination (GO:0045006)4.90343930
9regulation of T cell receptor signaling pathway (GO:0050856)4.82470049
10multi-organism reproductive behavior (GO:0044705)4.60801343
11reproductive behavior (GO:0019098)4.46279657
12L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.39827533
13indolalkylamine metabolic process (GO:0006586)4.22397054
14NLS-bearing protein import into nucleus (GO:0006607)4.21277859
15tryptophan metabolic process (GO:0006568)4.11662768
16adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.08985937
17transmission of nerve impulse (GO:0019226)3.79897080
18L-methionine salvage (GO:0071267)3.70038958
19L-methionine biosynthetic process (GO:0071265)3.70038958
20amino acid salvage (GO:0043102)3.70038958
21kynurenine metabolic process (GO:0070189)3.69017625
22negative regulation of myotube differentiation (GO:0010832)3.66219978
23regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.66015466
24indole-containing compound catabolic process (GO:0042436)3.63233767
25indolalkylamine catabolic process (GO:0046218)3.63233767
26tryptophan catabolic process (GO:0006569)3.63233767
27rRNA catabolic process (GO:0016075)3.61078311
28regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)3.60450649
29proline biosynthetic process (GO:0006561)3.58992166
30glomerular visceral epithelial cell development (GO:0072015)3.55425177
31long term synaptic depression (GO:0060292)3.48418480
32methionine biosynthetic process (GO:0009086)3.45318191
33viral entry into host cell (GO:0046718)3.43962873
34S-adenosylmethionine metabolic process (GO:0046500)3.40687030
35tachykinin receptor signaling pathway (GO:0007217)3.36111194
36regulation of DNA-templated transcription, initiation (GO:2000142)3.36030824
37synaptic transmission, dopaminergic (GO:0001963)3.32600058
38positive regulation of interleukin-2 production (GO:0032743)3.24761281
39respiratory chain complex IV assembly (GO:0008535)3.23699235
40G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.12400865
41regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.05509817
42fucose catabolic process (GO:0019317)3.03718179
43L-fucose metabolic process (GO:0042354)3.03718179
44L-fucose catabolic process (GO:0042355)3.03718179
45glomerular epithelial cell development (GO:0072310)3.03599662
46cytoplasmic microtubule organization (GO:0031122)3.03443159
47response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.03336745
48response to host immune response (GO:0052572)3.03336745
49detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.98793474
50cardiolipin metabolic process (GO:0032048)2.97467896
51positive regulation of cGMP biosynthetic process (GO:0030828)2.96225814
52attachment of spindle microtubules to kinetochore (GO:0008608)2.94777469
53nephron tubule formation (GO:0072079)2.94293107
54nitric oxide mediated signal transduction (GO:0007263)2.93209417
55startle response (GO:0001964)2.92433159
56methionine metabolic process (GO:0006555)2.90824696
57chaperone-mediated protein transport (GO:0072321)2.89868273
58cytochrome complex assembly (GO:0017004)2.88762494
59deoxyribonucleotide catabolic process (GO:0009264)2.86863198
60RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.84922837
61tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.84922837
62termination of RNA polymerase III transcription (GO:0006386)2.84792311
63transcription elongation from RNA polymerase III promoter (GO:0006385)2.84792311
64pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.84473485
65UMP metabolic process (GO:0046049)2.84473485
66pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.84473485
67UMP biosynthetic process (GO:0006222)2.84473485
68positive regulation of uterine smooth muscle contraction (GO:0070474)2.83225759
69regulation of metalloenzyme activity (GO:0048552)2.82389258
70cytidine deamination (GO:0009972)2.77085701
71cytidine metabolic process (GO:0046087)2.77085701
72cytidine catabolic process (GO:0006216)2.77085701
73detection of light stimulus involved in sensory perception (GO:0050962)2.73351075
74detection of light stimulus involved in visual perception (GO:0050908)2.73351075
75regulation of cGMP biosynthetic process (GO:0030826)2.72905778
76proline metabolic process (GO:0006560)2.70529480
77deoxyribose phosphate catabolic process (GO:0046386)2.69074572
78cellular ketone body metabolic process (GO:0046950)2.67858338
79parental behavior (GO:0060746)2.67679185
80detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.66055854
81regulation of rhodopsin mediated signaling pathway (GO:0022400)2.64352222
82microtubule severing (GO:0051013)2.63365351
83platelet dense granule organization (GO:0060155)2.61052698
84succinate metabolic process (GO:0006105)2.60440045
85indole-containing compound metabolic process (GO:0042430)2.59910619
86hydrogen peroxide catabolic process (GO:0042744)2.57964657
87movement in environment of other organism involved in symbiotic interaction (GO:0052192)2.57953871
88entry into cell of other organism involved in symbiotic interaction (GO:0051806)2.57953871
89entry into host (GO:0044409)2.57953871
90entry into other organism involved in symbiotic interaction (GO:0051828)2.57953871
91movement in host environment (GO:0052126)2.57953871
92entry into host cell (GO:0030260)2.57953871
93maternal behavior (GO:0042711)2.56458001
94intestinal epithelial cell development (GO:0060576)2.56040134
95response to amphetamine (GO:0001975)2.54947844
96negative regulation of smooth muscle contraction (GO:0045986)2.54287555
97nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.53350594
98detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.53096334
99female mating behavior (GO:0060180)13.7770447
100regulation of female receptivity (GO:0045924)13.1466533

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.24406992
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.69741755
3EZH2_22144423_ChIP-Seq_EOC_Human3.42416546
4VDR_22108803_ChIP-Seq_LS180_Human3.34273609
5GBX2_23144817_ChIP-Seq_PC3_Human2.92426199
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.89455850
7IGF1R_20145208_ChIP-Seq_DFB_Human2.88512851
8ZNF274_21170338_ChIP-Seq_K562_Hela2.75434643
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.58864446
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.08004015
11EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.06348770
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.01861427
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97400373
14P300_19829295_ChIP-Seq_ESCs_Human1.94426985
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.89665810
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89638191
17EWS_26573619_Chip-Seq_HEK293_Human1.88972602
18ER_23166858_ChIP-Seq_MCF-7_Human1.88919997
19FUS_26573619_Chip-Seq_HEK293_Human1.82364181
20TP53_22573176_ChIP-Seq_HFKS_Human1.75652566
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73855854
22SOX2_19829295_ChIP-Seq_ESCs_Human1.60441175
23NANOG_19829295_ChIP-Seq_ESCs_Human1.60441175
24GATA3_21878914_ChIP-Seq_MCF-7_Human1.59130040
25TCF4_22108803_ChIP-Seq_LS180_Human1.53852844
26POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52764692
27TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52764692
28E2F7_22180533_ChIP-Seq_HELA_Human1.52047051
29AR_21572438_ChIP-Seq_LNCaP_Human1.46758458
30HOXB7_26014856_ChIP-Seq_BT474_Human1.45762177
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.45698248
32GATA3_26560356_Chip-Seq_TH2_Human1.45591879
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42910692
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39868255
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38310474
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38160156
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.38097773
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34263029
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.34129365
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31625911
41TCF4_23295773_ChIP-Seq_U87_Human1.31309937
42PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.29705857
43FOXH1_21741376_ChIP-Seq_EPCs_Human1.28877622
44VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.28298309
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.26399896
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26319012
47FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25522704
48VDR_23849224_ChIP-Seq_CD4+_Human1.23544541
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23144138
50STAT3_23295773_ChIP-Seq_U87_Human1.22894371
51GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.22414828
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22073403
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19135751
54TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.19096415
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19087931
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.17779605
57ELK1_19687146_ChIP-ChIP_HELA_Human1.17415956
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15412310
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14827304
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.14827304
61AR_20517297_ChIP-Seq_VCAP_Human1.14264888
62ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13723196
63FOXP3_21729870_ChIP-Seq_TREG_Human1.12018837
64FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11966775
65TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11962568
66CDX2_22108803_ChIP-Seq_LS180_Human1.10719276
67NCOR_22424771_ChIP-Seq_293T_Human1.06211971
68FLI1_21867929_ChIP-Seq_TH2_Mouse1.05726377
69AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04839171
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.04534949
71SMAD4_21799915_ChIP-Seq_A2780_Human1.03121418
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00862055
73PRDM14_20953172_ChIP-Seq_ESCs_Human0.99940774
74MYC_18940864_ChIP-ChIP_HL60_Human0.98011625
75BCAT_22108803_ChIP-Seq_LS180_Human0.97831610
76FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97644247
77NFE2_27457419_Chip-Seq_LIVER_Mouse0.97643114
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97012673
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96448285
80TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95667812
81CBP_20019798_ChIP-Seq_JUKART_Human0.95447757
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95447757
83LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.94847610
84P53_21459846_ChIP-Seq_SAOS-2_Human0.94579866
85RXR_22108803_ChIP-Seq_LS180_Human0.94319111
86ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94118080
87FOXH1_21741376_ChIP-Seq_ESCs_Human0.93809719
88TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.93149609
89NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93008435
90RXRA_24833708_ChIP-Seq_LIVER_Mouse0.92999528
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92787028
92SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91985703
93SMRT_27268052_Chip-Seq_Bcells_Human0.90540481
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90360083
95EZH2_27294783_Chip-Seq_NPCs_Mouse0.90125371
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90087614
97LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88716503
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.88317541
99BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.88056885
100STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.86875807

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo6.42368041
2MP0003136_yellow_coat_color5.69212338
3MP0002163_abnormal_gland_morphology4.32642013
4MP0000372_irregular_coat_pigmentation3.47675832
5MP0002132_abnormal_respiratory_system3.06013888
6MP0000569_abnormal_digit_pigmentation3.02128524
7MP0004885_abnormal_endolymph3.01657051
8MP0005187_abnormal_penis_morphology2.97223469
9MP0003195_calcinosis2.94444951
10MP0005379_endocrine/exocrine_gland_phen2.68596581
11MP0005645_abnormal_hypothalamus_physiol2.65330260
12MP0004381_abnormal_hair_follicle2.54683888
13MP0003045_fibrosis2.45988781
14MP0008875_abnormal_xenobiotic_pharmacok2.34110893
15MP0006276_abnormal_autonomic_nervous2.27225508
16MP0002876_abnormal_thyroid_physiology2.22263766
17MP0003879_abnormal_hair_cell2.21814567
18MP0002909_abnormal_adrenal_gland2.09938189
19MP0005410_abnormal_fertilization2.08182593
20MP0003646_muscle_fatigue2.05857390
21MP0008775_abnormal_heart_ventricle2.04369971
22MP0001968_abnormal_touch/_nociception1.99013348
23MP0009697_abnormal_copulation1.95563521
24MP0002736_abnormal_nociception_after1.75531959
25MP0002138_abnormal_hepatobiliary_system1.62054331
26MP0005551_abnormal_eye_electrophysiolog1.59358138
27MP0002102_abnormal_ear_morphology1.55991014
28MP0009046_muscle_twitch1.54968447
29MP0001485_abnormal_pinna_reflex1.54140270
30MP0008877_abnormal_DNA_methylation1.51878844
31MP0003866_abnormal_defecation1.50744121
32MP0000647_abnormal_sebaceous_gland1.50062781
33MP0002168_other_aberrant_phenotype1.49827455
34MP0006036_abnormal_mitochondrial_physio1.39232144
35MP0000383_abnormal_hair_follicle1.39188272
36MP0000230_abnormal_systemic_arterial1.32091155
37MP0005395_other_phenotype1.27219954
38MP0008872_abnormal_physiological_respon1.26745059
39MP0006035_abnormal_mitochondrial_morpho1.24854113
40MP0003638_abnormal_response/metabolism_1.23375190
41MP0005646_abnormal_pituitary_gland1.22854466
42MP0001501_abnormal_sleep_pattern1.22621413
43MP0003786_premature_aging1.19592274
44MP0005360_urolithiasis1.18923978
45MP0003718_maternal_effect1.16668178
46MP0002090_abnormal_vision1.16049227
47MP0000681_abnormal_thyroid_gland1.15300635
48MP0005167_abnormal_blood-brain_barrier1.01444013
49MP0005671_abnormal_response_to0.90664160
50MP0000685_abnormal_immune_system0.89972366
51MP0006054_spinal_hemorrhage0.88613802
52MP0003806_abnormal_nucleotide_metabolis0.87246299
53MP0010094_abnormal_chromosome_stability0.84075789
54MP0001486_abnormal_startle_reflex0.83393828
55MP0004130_abnormal_muscle_cell0.82463607
56MP0001986_abnormal_taste_sensitivity0.82142781
57MP0009765_abnormal_xenobiotic_induced0.81496910
58MP0003938_abnormal_ear_development0.80731132
59MP0008789_abnormal_olfactory_epithelium0.80047966
60MP0004145_abnormal_muscle_electrophysio0.78508498
61MP0006072_abnormal_retinal_apoptosis0.78423192
62MP0005253_abnormal_eye_physiology0.74502958
63MP0001348_abnormal_lacrimal_gland0.73296417
64MP0002148_abnormal_hypersensitivity_rea0.71845045
65MP0002282_abnormal_trachea_morphology0.70538684
66MP0010678_abnormal_skin_adnexa0.69424651
67MP0003077_abnormal_cell_cycle0.67966734
68MP0003252_abnormal_bile_duct0.65817558
69MP0001346_abnormal_lacrimal_gland0.65366040
70MP0004085_abnormal_heartbeat0.64988365
71MP0009764_decreased_sensitivity_to0.64969247
72MP0000631_abnormal_neuroendocrine_gland0.64910812
73MP0004215_abnormal_myocardial_fiber0.64652337
74MP0002272_abnormal_nervous_system0.64629139
75MP0001963_abnormal_hearing_physiology0.62445881
76MP0009745_abnormal_behavioral_response0.62385925
77MP0001188_hyperpigmentation0.62045163
78MP0005310_abnormal_salivary_gland0.61746313
79MP0003119_abnormal_digestive_system0.61430457
80MP0008995_early_reproductive_senescence0.58800549
81MP0004782_abnormal_surfactant_physiolog0.58017894
82MP0009763_increased_sensitivity_to0.57664407
83MP0001929_abnormal_gametogenesis0.56973432
84MP0002210_abnormal_sex_determination0.56768965
85MP0003724_increased_susceptibility_to0.56418322
86MP0001800_abnormal_humoral_immune0.55679213
87MP0005319_abnormal_enzyme/_coenzyme0.55567529
88MP0005174_abnormal_tail_pigmentation0.55409061
89MP0002160_abnormal_reproductive_system0.55069610
90MP0003137_abnormal_impulse_conducting0.52593642
91MP0001756_abnormal_urination0.52303390
92MP0000049_abnormal_middle_ear0.52180761
93MP0002557_abnormal_social/conspecific_i0.50763870
94MP0005636_abnormal_mineral_homeostasis0.50499723
95MP0001835_abnormal_antigen_presentation0.49648844
96MP0005464_abnormal_platelet_physiology0.47623002
97MP0010155_abnormal_intestine_physiology0.46802541
98MP0000653_abnormal_sex_gland0.46630848
99MP0002452_abnormal_antigen_presenting0.45869600
100MP0001984_abnormal_olfaction0.45064542

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)4.84668934
2Premature skin wrinkling (HP:0100678)4.38138426
3Mesangial abnormality (HP:0001966)4.28495055
4Congenital stationary night blindness (HP:0007642)4.22878381
5Abnormal rod and cone electroretinograms (HP:0008323)4.12608732
6Tubular atrophy (HP:0000092)4.05477888
7Neonatal respiratory distress (HP:0002643)3.81154023
8Hypoproteinemia (HP:0003075)3.80732105
9Hemiparesis (HP:0001269)3.69038925
10Short chin (HP:0000331)3.66385359
11Anhidrosis (HP:0000970)3.64047862
12Keratoconjunctivitis (HP:0001096)3.35381347
13Abnormality of macular pigmentation (HP:0008002)3.35165143
14Conical tooth (HP:0000698)3.26821922
15Attenuation of retinal blood vessels (HP:0007843)3.23136847
16True hermaphroditism (HP:0010459)3.22138388
17Increased connective tissue (HP:0009025)3.13812829
18Keratoconjunctivitis sicca (HP:0001097)3.02029940
19Bile duct proliferation (HP:0001408)3.00779088
20Abnormal biliary tract physiology (HP:0012439)3.00779088
21Oligodontia (HP:0000677)3.00766955
22Decreased electroretinogram (ERG) amplitude (HP:0000654)2.97496485
23Palpitations (HP:0001962)2.86938140
24Conjunctival hamartoma (HP:0100780)2.81446993
25Centrally nucleated skeletal muscle fibers (HP:0003687)2.78786539
26Gaze-evoked nystagmus (HP:0000640)2.74978914
27Pustule (HP:0200039)2.72693860
28Severe visual impairment (HP:0001141)2.68808843
29Pelvic girdle muscle weakness (HP:0003749)2.67442567
3011 pairs of ribs (HP:0000878)2.63635430
31Abnormal sex determination (HP:0012244)2.63544218
32Sex reversal (HP:0012245)2.63544218
33Pheochromocytoma (HP:0002666)2.63257605
34Esophageal neoplasm (HP:0100751)2.60194570
35Neoplasm of head and neck (HP:0012288)2.60194570
36Neuroendocrine neoplasm (HP:0100634)2.60013971
37Hamartoma of the eye (HP:0010568)2.59468785
38Absent eyebrow (HP:0002223)2.59166293
39Shoulder girdle muscle weakness (HP:0003547)2.52417620
40Type II lissencephaly (HP:0007260)2.48376312
41Abnormality of B cell number (HP:0010975)2.47513729
42Pancreatic cysts (HP:0001737)2.40892872
43Erythroderma (HP:0001019)2.38882030
44Cerebral hemorrhage (HP:0001342)2.37578312
45Rimmed vacuoles (HP:0003805)2.34745696
46Bony spicule pigmentary retinopathy (HP:0007737)2.26138235
47Type I diabetes mellitus (HP:0100651)2.25505806
48Sparse eyelashes (HP:0000653)2.23001544
49Brittle hair (HP:0002299)2.21312392
50Prostate neoplasm (HP:0100787)2.19400486
51Increased CSF lactate (HP:0002490)2.18757396
52Redundant skin (HP:0001582)2.17608473
53Hepatocellular necrosis (HP:0001404)2.13086568
54B lymphocytopenia (HP:0010976)2.11134133
55Abnormality of the hip-girdle musculature (HP:0001445)2.09937203
56Abnormality of the musculature of the pelvis (HP:0001469)2.09937203
57Hypoplasia of the fovea (HP:0007750)2.08084335
58Aplasia/Hypoplasia of the fovea (HP:0008060)2.08084335
59Cerebellar dysplasia (HP:0007033)2.06228526
60Thyroid-stimulating hormone excess (HP:0002925)2.06025185
61Pigmentary retinal degeneration (HP:0001146)2.05532365
62Pancreatic fibrosis (HP:0100732)2.05120874
63Decreased central vision (HP:0007663)2.05071328
64Respiratory difficulties (HP:0002880)2.04413687
65Cerebral hypomyelination (HP:0006808)2.02471136
66Mitochondrial inheritance (HP:0001427)2.02132641
67Abnormal tarsal ossification (HP:0008369)2.01990759
68Acute necrotizing encephalopathy (HP:0006965)1.97067115
69Hyperthyroidism (HP:0000836)1.96830167
70Ependymoma (HP:0002888)1.95255328
71Abolished electroretinogram (ERG) (HP:0000550)1.94804118
72Hypothermia (HP:0002045)1.94451900
73Elevated erythrocyte sedimentation rate (HP:0003565)1.93984848
74Hepatic necrosis (HP:0002605)1.89038708
75Colon cancer (HP:0003003)1.88522017
76Acute encephalopathy (HP:0006846)1.87651940
77Progressive inability to walk (HP:0002505)1.87367515
78Hypoplastic iliac wings (HP:0002866)1.87124400
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86252685
80Abnormality of alanine metabolism (HP:0010916)1.86252685
81Hyperalaninemia (HP:0003348)1.86252685
82Abnormal mitochondria in muscle tissue (HP:0008316)1.85925963
83Tinnitus (HP:0000360)1.85866789
84Neoplasm of the adrenal gland (HP:0100631)1.84893517
85Dysphonia (HP:0001618)1.84143057
86Birth length less than 3rd percentile (HP:0003561)1.82341055
87Male pseudohermaphroditism (HP:0000037)1.81658660
88Spinal muscular atrophy (HP:0007269)1.80106607
89Eosinophilia (HP:0001880)1.74112326
90Genetic anticipation (HP:0003743)1.72676241
91Hypoplastic nipples (HP:0002557)1.72401038
92Cystic liver disease (HP:0006706)1.71556887
93Angiofibromas (HP:0010615)1.69042801
94Adenoma sebaceum (HP:0009720)1.69042801
95Abnormality of the prostate (HP:0008775)1.67553945
96Cone-rod dystrophy (HP:0000548)1.67492386
97Increased serum lactate (HP:0002151)1.67077451
98Congenital hip dislocation (HP:0001374)1.65943311
99Neoplasm of the rectum (HP:0100743)1.65842602
100Abnormality of male internal genitalia (HP:0000022)1.65602910

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.53641988
2MST43.80401828
3VRK23.26677593
4BUB13.07073660
5NUAK12.74037685
6EIF2AK32.72147316
7ADRBK22.69935596
8TIE12.64041604
9MKNK22.56641219
10PLK22.56604608
11TAF12.32967130
12CDK122.27859614
13KIT2.21730468
14MAP4K22.13056678
15OXSR12.06335579
16STK391.96552754
17EIF2AK11.93524073
18TXK1.77265229
19PINK11.65479560
20DAPK21.65284981
21VRK11.59425572
22GRK11.58671916
23TEC1.58530014
24MKNK11.58421545
25TAOK31.50895644
26ERBB21.48222050
27NEK11.37030992
28TSSK61.35203836
29TLK11.32147737
30CSNK1A1L1.28730406
31CSNK1G31.26460013
32ZAK1.25212109
33WNK41.24373766
34BCR1.19248552
35EIF2AK21.15389784
36ITK1.13860627
37PLK31.13088148
38KDR1.11081189
39PAK31.11006790
40ACVR1B1.03024824
41GRK50.96672926
42CSNK1G20.94919819
43PIM20.94518733
44IKBKB0.93493773
45DAPK10.87444765
46SYK0.87272401
47CSNK1G10.84719843
48PIK3CA0.84564191
49PHKG20.82726392
50PHKG10.82726392
51BMPR1B0.82072098
52PRKCI0.80876767
53PLK10.77974184
54BCKDK0.77721920
55INSRR0.76497799
56DYRK20.74288376
57WNK30.73300243
58MAP2K70.71368865
59PLK40.71185539
60ADRBK10.68688473
61IRAK30.67664295
62BRSK10.66795150
63MAP3K40.66634476
64PRKCE0.64134578
65MAP2K60.62296142
66PTK2B0.61223134
67MAPKAPK50.59452525
68EGFR0.59001355
69AURKB0.56521029
70BTK0.52767643
71PIK3CG0.47474548
72MAP3K100.47042856
73MAP3K10.46581387
74CLK10.46246896
75NME10.45412879
76PDK20.44141681
77DAPK30.44043432
78CSNK2A10.43381851
79ARAF0.41523009
80PRKCG0.40820029
81MINK10.39277274
82STK380.38665065
83CSNK1A10.38488709
84CHUK0.38283815
85PRKAA20.37385434
86PRKCQ0.36590251
87CDC70.36468745
88SMG10.35795120
89LYN0.35726531
90ROCK10.34372483
91CAMK2D0.34331575
92PRKCB0.34265845
93ATM0.33187332
94STK40.32935540
95LCK0.32235071
96CAMK2A0.32196459
97RPS6KA50.31881806
98WNK10.31637004
99IKBKE0.28083544
100CDK140.27535652

Predicted pathways (KEGG)

RankGene SetZ-score
1Tryptophan metabolism_Homo sapiens_hsa003803.92242343
2RNA polymerase_Homo sapiens_hsa030203.44407838
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.29086915
4Proteasome_Homo sapiens_hsa030502.50645464
5Caffeine metabolism_Homo sapiens_hsa002322.42459418
6One carbon pool by folate_Homo sapiens_hsa006702.40033327
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.39820738
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.38337418
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.35807134
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.03835623
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.97428075
12Homologous recombination_Homo sapiens_hsa034401.89706757
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.88000060
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80173505
15Salivary secretion_Homo sapiens_hsa049701.77185186
16Sulfur relay system_Homo sapiens_hsa041221.69427150
17Pyrimidine metabolism_Homo sapiens_hsa002401.63632377
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.62863483
19Purine metabolism_Homo sapiens_hsa002301.58081578
20Phototransduction_Homo sapiens_hsa047441.49105111
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48557123
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.44121402
23Parkinsons disease_Homo sapiens_hsa050121.41313160
24Butanoate metabolism_Homo sapiens_hsa006501.39633123
25Nitrogen metabolism_Homo sapiens_hsa009101.36746774
26Mismatch repair_Homo sapiens_hsa034301.36380760
27DNA replication_Homo sapiens_hsa030301.34482380
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31500305
29Linoleic acid metabolism_Homo sapiens_hsa005911.28264426
30Basal transcription factors_Homo sapiens_hsa030221.26507704
31RNA degradation_Homo sapiens_hsa030181.25956177
32Oxidative phosphorylation_Homo sapiens_hsa001901.16917523
33Primary immunodeficiency_Homo sapiens_hsa053401.14183035
34Fatty acid biosynthesis_Homo sapiens_hsa000611.10925351
35Olfactory transduction_Homo sapiens_hsa047401.07195636
36Asthma_Homo sapiens_hsa053101.06511666
37Non-homologous end-joining_Homo sapiens_hsa034501.06372219
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03468936
39Chemical carcinogenesis_Homo sapiens_hsa052041.03200972
40Lysine degradation_Homo sapiens_hsa003101.02706026
41Circadian entrainment_Homo sapiens_hsa047131.02443741
42Fatty acid elongation_Homo sapiens_hsa000621.02090944
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01996402
44Fatty acid metabolism_Homo sapiens_hsa012121.01550526
45Arginine and proline metabolism_Homo sapiens_hsa003300.98321335
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98140300
47Arginine biosynthesis_Homo sapiens_hsa002200.95628311
48Calcium signaling pathway_Homo sapiens_hsa040200.94864852
49ABC transporters_Homo sapiens_hsa020100.93409121
50Propanoate metabolism_Homo sapiens_hsa006400.91392684
51Huntingtons disease_Homo sapiens_hsa050160.90651028
52Allograft rejection_Homo sapiens_hsa053300.87146268
53Fatty acid degradation_Homo sapiens_hsa000710.84689214
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84682169
55Alzheimers disease_Homo sapiens_hsa050100.84528201
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.80917820
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78814276
58Graft-versus-host disease_Homo sapiens_hsa053320.78070974
59Systemic lupus erythematosus_Homo sapiens_hsa053220.77965168
60Nicotine addiction_Homo sapiens_hsa050330.76558421
61Type I diabetes mellitus_Homo sapiens_hsa049400.75728296
62Autoimmune thyroid disease_Homo sapiens_hsa053200.74132485
63Renin secretion_Homo sapiens_hsa049240.74116619
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.73386440
65Selenocompound metabolism_Homo sapiens_hsa004500.73319988
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69420037
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68490403
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.66216241
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65114655
70Metabolic pathways_Homo sapiens_hsa011000.64604877
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63319244
72Regulation of autophagy_Homo sapiens_hsa041400.62619277
73Taste transduction_Homo sapiens_hsa047420.62203628
74Morphine addiction_Homo sapiens_hsa050320.61316716
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.60112104
76Long-term depression_Homo sapiens_hsa047300.59690995
77RNA transport_Homo sapiens_hsa030130.58583512
78p53 signaling pathway_Homo sapiens_hsa041150.58194453
79Cardiac muscle contraction_Homo sapiens_hsa042600.57969977
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56268240
81Retinol metabolism_Homo sapiens_hsa008300.56230281
82Glycerolipid metabolism_Homo sapiens_hsa005610.56105978
83Fanconi anemia pathway_Homo sapiens_hsa034600.52939018
84Peroxisome_Homo sapiens_hsa041460.51416927
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50923936
86Legionellosis_Homo sapiens_hsa051340.48145340
87GABAergic synapse_Homo sapiens_hsa047270.46548555
88Epstein-Barr virus infection_Homo sapiens_hsa051690.46427467
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.45463268
90African trypanosomiasis_Homo sapiens_hsa051430.44594965
91Oocyte meiosis_Homo sapiens_hsa041140.42623258
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41627015
93Rheumatoid arthritis_Homo sapiens_hsa053230.39946268
94Oxytocin signaling pathway_Homo sapiens_hsa049210.38288525
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38002055
96Carbon metabolism_Homo sapiens_hsa012000.37105943
97Arachidonic acid metabolism_Homo sapiens_hsa005900.36441374
98Alcoholism_Homo sapiens_hsa050340.35183718
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35039828
100Tyrosine metabolism_Homo sapiens_hsa003500.32777929

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »