H2AFZP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gonadal mesoderm development (GO:0007506)8.57529576
2regulation of regulatory T cell differentiation (GO:0045589)6.72173690
3mature B cell differentiation involved in immune response (GO:0002313)6.05804038
4interferon-gamma production (GO:0032609)5.74338666
5tolerance induction (GO:0002507)5.65113531
6positive regulation of gamma-delta T cell activation (GO:0046645)5.51570320
7mast cell activation (GO:0045576)5.22641232
8protein polyglutamylation (GO:0018095)4.98380589
9regulation of gamma-delta T cell differentiation (GO:0045586)4.96515944
10regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.78034026
11positive regulation of humoral immune response (GO:0002922)4.64961351
12mature B cell differentiation (GO:0002335)4.45344225
13negative regulation of nitric oxide biosynthetic process (GO:0045019)4.37014548
14positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)4.31230128
15radial glial cell differentiation (GO:0060019)4.17116115
16positive regulation of defense response to virus by host (GO:0002230)4.13597067
17regulation of gamma-delta T cell activation (GO:0046643)4.01472969
18positive regulation of mRNA catabolic process (GO:0061014)3.89769502
19regulation of mRNA catabolic process (GO:0061013)3.86518391
20cellular response to exogenous dsRNA (GO:0071360)3.86013413
21mismatch repair (GO:0006298)3.85641119
22tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.84341977
23RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.84341977
24detection of light stimulus involved in sensory perception (GO:0050962)3.84241434
25detection of light stimulus involved in visual perception (GO:0050908)3.84241434
26positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.75107057
27T cell differentiation (GO:0030217)3.74605299
28transcription elongation from RNA polymerase III promoter (GO:0006385)3.73622762
29termination of RNA polymerase III transcription (GO:0006386)3.73622762
30hepatocyte apoptotic process (GO:0097284)3.70104699
31positive regulation of endothelial cell differentiation (GO:0045603)3.67725340
32lymphoid progenitor cell differentiation (GO:0002320)3.67643920
33regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.66502368
34regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.65056815
35positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.65056815
36regulation of mitochondrial translation (GO:0070129)3.63904940
37negative regulation of viral transcription (GO:0032897)3.61092959
38negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.61044986
39B cell activation involved in immune response (GO:0002312)3.56934813
40alpha-beta T cell differentiation (GO:0046632)3.42850958
41positive regulation of T cell cytokine production (GO:0002726)3.39293804
42ribosomal small subunit assembly (GO:0000028)3.38609336
43positive regulation of T cell mediated cytotoxicity (GO:0001916)3.37234371
44toxin transport (GO:1901998)3.34628009
45negative regulation by host of viral transcription (GO:0043922)3.32783798
46pantothenate metabolic process (GO:0015939)3.31230305
47regulation of RIG-I signaling pathway (GO:0039535)3.29503625
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.28837098
49positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.28366335
50regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.28366335
51response to corticosterone (GO:0051412)3.25337079
52positive regulation of cAMP-mediated signaling (GO:0043950)3.24500567
53mitochondrial calcium ion transport (GO:0006851)3.21145133
54positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.20355307
55establishment of integrated proviral latency (GO:0075713)3.20241144
56DNA ligation (GO:0006266)3.19828143
57regulation of response to interferon-gamma (GO:0060330)3.19530326
58somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.18402733
59isotype switching (GO:0045190)3.18402733
60somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.18402733
61regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.17465303
62myeloid dendritic cell activation (GO:0001773)3.15422534
63regulation of thymocyte apoptotic process (GO:0070243)3.15089975
64dosage compensation (GO:0007549)3.12995919
65positive regulation of alpha-beta T cell differentiation (GO:0046638)3.12959977
66positive thymic T cell selection (GO:0045059)3.12404041
67temperature homeostasis (GO:0001659)3.09635159
68alpha-beta T cell activation (GO:0046631)3.08584022
69myeloid dendritic cell differentiation (GO:0043011)3.04113288
70V(D)J recombination (GO:0033151)3.02935153
71positive regulation of interleukin-4 production (GO:0032753)3.00223118
72phosphatidylserine acyl-chain remodeling (GO:0036150)2.98904521
73positive regulation of interferon-beta production (GO:0032728)2.97465916
74regulation of germinal center formation (GO:0002634)2.93910116
75regulation of T cell mediated cytotoxicity (GO:0001914)2.93362264
76positive regulation of immunoglobulin mediated immune response (GO:0002891)2.92537748
77positive regulation of B cell mediated immunity (GO:0002714)2.92537748
78regulation of interleukin-13 production (GO:0032656)2.91673439
79COPII vesicle coating (GO:0048208)2.91614569
80maturation of SSU-rRNA (GO:0030490)2.91434341
81single strand break repair (GO:0000012)2.90203370
82regulation of alpha-beta T cell differentiation (GO:0046637)2.89519829
83cellular response to interferon-beta (GO:0035458)2.88798082
84viral transcription (GO:0019083)2.88348155
85regulation of endothelial cell differentiation (GO:0045601)2.87967663
86regulation of beta-amyloid formation (GO:1902003)2.87885481
87positive regulation of natural killer cell mediated immunity (GO:0002717)2.86396455
88B cell homeostasis (GO:0001782)2.86042207
89translational termination (GO:0006415)2.85999241
90DNA deamination (GO:0045006)2.85561451
91neurofilament cytoskeleton organization (GO:0060052)2.84905284
92positive regulation of cytokine production involved in immune response (GO:0002720)2.83807090
93transcription from mitochondrial promoter (GO:0006390)2.82791120
94positive regulation of cell killing (GO:0031343)2.82407471
95regulation of interleukin-4 production (GO:0032673)2.81911632
96growth hormone receptor signaling pathway (GO:0060396)2.81348360
97negative regulation of execution phase of apoptosis (GO:1900118)2.80315997
98mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.79254845
99positive regulation of T cell mediated immunity (GO:0002711)2.79016996
100positive T cell selection (GO:0043368)2.78782343

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.51226709
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.24905249
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.14838651
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.80770671
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.33880008
6FLI1_27457419_Chip-Seq_LIVER_Mouse3.21460789
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.93211534
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.58441609
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.55147539
10EZH2_22144423_ChIP-Seq_EOC_Human2.51766375
11GATA1_22025678_ChIP-Seq_K562_Human2.39979345
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.25052211
13MYB_26560356_Chip-Seq_TH2_Human2.21601518
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.17679267
15STAT1_20625510_ChIP-Seq_HELA_Human2.15416514
16GATA3_26560356_Chip-Seq_TH2_Human2.07865658
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.07664826
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.07267647
19LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.97442773
20RUNX_20019798_ChIP-Seq_JUKART_Human1.96369155
21TAF15_26573619_Chip-Seq_HEK293_Human1.90147254
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.78515057
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76290657
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.75745022
25PCGF2_27294783_Chip-Seq_NPCs_Mouse1.73724369
26ZNF274_21170338_ChIP-Seq_K562_Hela1.69709708
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63402992
28ELK1_19687146_ChIP-ChIP_HELA_Human1.62615156
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.59566143
30VDR_23849224_ChIP-Seq_CD4+_Human1.53869147
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.53222450
32GATA3_27048872_Chip-Seq_THYMUS_Human1.50905494
33TP53_22573176_ChIP-Seq_HFKS_Human1.50588841
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38475532
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38295825
36SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37961068
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.36053010
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33129480
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.32661375
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.30701723
41MAF_26560356_Chip-Seq_TH2_Human1.28118923
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.27356138
43FOXP3_21729870_ChIP-Seq_TREG_Human1.27060667
44ER_23166858_ChIP-Seq_MCF-7_Human1.26237045
45AR_20517297_ChIP-Seq_VCAP_Human1.24645241
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23764669
47ELK1_22589737_ChIP-Seq_MCF10A_Human1.22163611
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20398571
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19068904
50UTX_26944678_Chip-Seq_JUKART_Human1.18903627
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17457164
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15428003
53MAF_26560356_Chip-Seq_TH1_Human1.13787404
54MYB_26560356_Chip-Seq_TH1_Human1.12959204
55GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.12748858
56AR_21572438_ChIP-Seq_LNCaP_Human1.10621587
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10536251
58TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09621100
59FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08116791
60GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06165087
61CIITA_25753668_ChIP-Seq_RAJI_Human1.04014327
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02946832
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02602429
64NCOR_22424771_ChIP-Seq_293T_Human1.01862402
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98438901
66RBPJ_21746931_ChIP-Seq_IB4_Human0.98431747
67ERG_20517297_ChIP-Seq_VCAP_Human0.97751626
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97297872
69LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96590679
70PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.96150901
71GATA3_21878914_ChIP-Seq_MCF-7_Human0.95012892
72ETV1_20927104_ChIP-Seq_GIST48_Human0.94145022
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92220351
74STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.92153416
75HOXB7_26014856_ChIP-Seq_BT474_Human0.91715220
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90384224
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88818165
78ELF1_17652178_ChIP-ChIP_JURKAT_Human0.88783123
79ERA_21632823_ChIP-Seq_H3396_Human0.87877228
80GATA6_21074721_ChIP-Seq_CACO-2_Human0.87629125
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87133685
82NFYB_21822215_ChIP-Seq_K562_Human0.84620299
83E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.84242420
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84102934
85TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.83584097
86FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83475792
87ETS1_20019798_ChIP-Seq_JURKAT_Human0.82392598
88RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81936748
89CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.81860613
90IGF1R_20145208_ChIP-Seq_DFB_Human0.81433353
91EZH2_27294783_Chip-Seq_NPCs_Mouse0.81245010
92OCT4_21477851_ChIP-Seq_ESCs_Mouse0.80690075
93TAL1_26923725_Chip-Seq_HPCs_Mouse0.80425525
94VDR_22108803_ChIP-Seq_LS180_Human0.80372033
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79906624
96EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.79388866
97TTF2_22483619_ChIP-Seq_HELA_Human0.78360391
98PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77719380
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77694836
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.77573821

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.37554702
2MP0005075_abnormal_melanosome_morpholog3.76005580
3MP0003866_abnormal_defecation3.71444704
4MP0003300_gastrointestinal_ulcer3.20018289
5MP0008877_abnormal_DNA_methylation2.85797963
6MP0004381_abnormal_hair_follicle2.81195974
7MP0003763_abnormal_thymus_physiology2.49943391
8MP0010155_abnormal_intestine_physiology2.45507184
9MP0003045_fibrosis2.41442973
10MP0000685_abnormal_immune_system2.36202242
11MP0000465_gastrointestinal_hemorrhage2.30003642
12MP0001800_abnormal_humoral_immune2.25938740
13MP0002736_abnormal_nociception_after2.16798492
14MP0009379_abnormal_foot_pigmentation2.15636064
15MP0003806_abnormal_nucleotide_metabolis2.14079896
16MP0003943_abnormal_hepatobiliary_system2.11745936
17MP0003787_abnormal_imprinting2.05149605
18MP0005000_abnormal_immune_tolerance2.04387356
19MP0003195_calcinosis1.96947854
20MP0000372_irregular_coat_pigmentation1.94451246
21MP0003646_muscle_fatigue1.80162902
22MP0008995_early_reproductive_senescence1.79244672
23MP0006072_abnormal_retinal_apoptosis1.77519276
24MP0005551_abnormal_eye_electrophysiolog1.72626346
25MP0001873_stomach_inflammation1.71238933
26MP0002452_abnormal_antigen_presenting1.70838772
27MP0002723_abnormal_immune_serum1.65629689
28MP0002837_dystrophic_cardiac_calcinosis1.64266793
29MP0004947_skin_inflammation1.58237638
30MP0001819_abnormal_immune_cell1.56868388
31MP0001968_abnormal_touch/_nociception1.55873850
32MP0001919_abnormal_reproductive_system1.54386271
33MP0005408_hypopigmentation1.53977353
34MP0009764_decreased_sensitivity_to1.52748774
35MP0002420_abnormal_adaptive_immunity1.52400406
36MP0000490_abnormal_crypts_of1.52281404
37MP0003890_abnormal_embryonic-extraembry1.49174620
38MP0001835_abnormal_antigen_presentation1.48994256
39MP0000703_abnormal_thymus_morphology1.47416481
40MP0003724_increased_susceptibility_to1.46627920
41MP0009333_abnormal_splenocyte_physiolog1.44501143
42MP0003786_premature_aging1.42246261
43MP0002148_abnormal_hypersensitivity_rea1.41697871
44MP0003252_abnormal_bile_duct1.34045954
45MP0005451_abnormal_body_composition1.33674811
46MP0006036_abnormal_mitochondrial_physio1.32458286
47MP0005367_renal/urinary_system_phenotyp1.31035544
48MP0000516_abnormal_urinary_system1.31035544
49MP0000716_abnormal_immune_system1.30740052
50MP0009785_altered_susceptibility_to1.28877594
51MP0003638_abnormal_response/metabolism_1.27989410
52MP0002398_abnormal_bone_marrow1.27912793
53MP0008872_abnormal_physiological_respon1.27418594
54MP0004147_increased_porphyrin_level1.24920183
55MP0008775_abnormal_heart_ventricle1.24073129
56MP0005025_abnormal_response_to1.21687356
57MP0005257_abnormal_intraocular_pressure1.20856279
58MP0002928_abnormal_bile_duct1.17053191
59MP0001845_abnormal_inflammatory_respons1.15033344
60MP0005387_immune_system_phenotype1.13990483
61MP0001790_abnormal_immune_system1.13990483
62MP0004215_abnormal_myocardial_fiber1.11638794
63MP0005410_abnormal_fertilization1.11265573
64MP0001542_abnormal_bone_strength1.10731456
65MP0000689_abnormal_spleen_morphology1.10626594
66MP0002168_other_aberrant_phenotype1.08971021
67MP0002722_abnormal_immune_system1.08830521
68MP0004145_abnormal_muscle_electrophysio1.07408736
69MP0001324_abnormal_eye_pigmentation1.05031437
70MP0001986_abnormal_taste_sensitivity1.01750074
71MP0002429_abnormal_blood_cell1.00581935
72MP0002396_abnormal_hematopoietic_system0.99868189
73MP0005253_abnormal_eye_physiology0.99851488
74MP0005464_abnormal_platelet_physiology0.98974224
75MP0005389_reproductive_system_phenotype0.98933169
76MP0003436_decreased_susceptibility_to0.97866917
77MP0010094_abnormal_chromosome_stability0.88324416
78MP0002136_abnormal_kidney_physiology0.88130273
79MP0002653_abnormal_ependyma_morphology0.87482906
80MP0001727_abnormal_embryo_implantation0.87034991
81MP0005085_abnormal_gallbladder_physiolo0.86110692
82MP0004808_abnormal_hematopoietic_stem0.83299257
83MP0002933_joint_inflammation0.81236604
84MP0009765_abnormal_xenobiotic_induced0.80463099
85MP0001756_abnormal_urination0.80303596
86MP0004019_abnormal_vitamin_homeostasis0.80263506
87MP0001663_abnormal_digestive_system0.79011572
88MP0001501_abnormal_sleep_pattern0.77144226
89MP0002419_abnormal_innate_immunity0.76622240
90MP0003221_abnormal_cardiomyocyte_apopto0.76258929
91MP0002638_abnormal_pupillary_reflex0.75826003
92MP0005266_abnormal_metabolism0.74897059
93MP0008004_abnormal_stomach_pH0.74750041
94MP0009643_abnormal_urine_homeostasis0.74688484
95MP0006276_abnormal_autonomic_nervous0.73858824
96MP0008469_abnormal_protein_level0.73426308
97MP0001486_abnormal_startle_reflex0.70504372
98MP0001533_abnormal_skeleton_physiology0.70217021
99MP0009780_abnormal_chondrocyte_physiolo0.70007608
100MP0003448_altered_tumor_morphology0.68217142

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)7.24185738
2B lymphocytopenia (HP:0010976)5.85835958
3Abnormality of B cell number (HP:0010975)5.34787126
4IgG deficiency (HP:0004315)5.29963007
5Cerebral hypomyelination (HP:0006808)4.78875073
6Hyperthyroidism (HP:0000836)4.35958900
7Abnormality of macular pigmentation (HP:0008002)4.13996534
8IgM deficiency (HP:0002850)4.08601874
9Severe combined immunodeficiency (HP:0004430)4.00031107
10Recurrent bronchitis (HP:0002837)3.99375366
11Oligodontia (HP:0000677)3.97055570
12Seborrheic dermatitis (HP:0001051)3.82716549
13Hypoparathyroidism (HP:0000829)3.54054442
14Abnormality of T cell physiology (HP:0011840)3.50913886
15Thyroiditis (HP:0100646)3.48531493
16Abnormality of T cells (HP:0002843)3.39335547
17Stomatitis (HP:0010280)3.30370300
18Degeneration of the lateral corticospinal tracts (HP:0002314)3.28650170
19Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.28650170
20Combined immunodeficiency (HP:0005387)3.09624222
21Chronic diarrhea (HP:0002028)3.09190461
22Abnormality of the periventricular white matter (HP:0002518)3.05745450
23Interstitial pulmonary disease (HP:0006530)3.03009093
24Abnormality of eosinophils (HP:0001879)2.94254849
25Truncus arteriosus (HP:0001660)2.92087600
26Myositis (HP:0100614)2.88645021
27Pancreatic cysts (HP:0001737)2.85605567
28Impaired smooth pursuit (HP:0007772)2.83935153
29True hermaphroditism (HP:0010459)2.77938618
30Hepatocellular necrosis (HP:0001404)2.77042827
31Renal cortical cysts (HP:0000803)2.74804531
32Atelectasis (HP:0100750)2.73265103
33Mitochondrial inheritance (HP:0001427)2.69456060
34Pustule (HP:0200039)2.67970237
35Abnormality of the tricuspid valve (HP:0001702)2.66522602
36Acute necrotizing encephalopathy (HP:0006965)2.64978487
37Palpitations (HP:0001962)2.64393021
38Sparse lateral eyebrow (HP:0005338)2.61387596
39Pancreatic fibrosis (HP:0100732)2.61101703
40Eczematoid dermatitis (HP:0000976)2.59502983
41Hypocalcemia (HP:0002901)2.59045872
42Abnormal number of erythroid precursors (HP:0012131)2.58490522
43Hepatic necrosis (HP:0002605)2.56701702
44Asthma (HP:0002099)2.55898922
45Prostate neoplasm (HP:0100787)2.55031398
46Obstructive lung disease (HP:0006536)2.54356728
47Chronic obstructive pulmonary disease (HP:0006510)2.54356728
48Horizontal nystagmus (HP:0000666)2.53617683
49Hypertensive crisis (HP:0100735)2.49455333
50Abnormal rod and cone electroretinograms (HP:0008323)2.45025449
51Hypogonadotrophic hypogonadism (HP:0000044)2.44677066
52T lymphocytopenia (HP:0005403)2.44623869
53Gait imbalance (HP:0002141)2.44024150
54Intention tremor (HP:0002080)2.43679919
55Congenital primary aphakia (HP:0007707)2.39777885
56Abnormality of cells of the erythroid lineage (HP:0012130)2.38131491
57Congenital stationary night blindness (HP:0007642)2.36835857
58Progressive microcephaly (HP:0000253)2.36178382
59Abnormality of the costochondral junction (HP:0000919)2.35053295
60Increased CSF lactate (HP:0002490)2.34898117
61Abnormality of the corticospinal tract (HP:0002492)2.33096890
62Lymphoma (HP:0002665)2.28678844
63Recurrent sinusitis (HP:0011108)2.28290131
64Increased IgE level (HP:0003212)2.26485848
65Abnormal mitochondria in muscle tissue (HP:0008316)2.25085072
66Medial flaring of the eyebrow (HP:0010747)2.22106308
67Round ear (HP:0100830)2.21195694
68Decreased activity of mitochondrial respiratory chain (HP:0008972)2.20078443
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.20078443
70Autoimmune hemolytic anemia (HP:0001890)2.17382284
71Male pseudohermaphroditism (HP:0000037)2.14357958
72Leukocytosis (HP:0001974)2.14132993
73Bronchitis (HP:0012387)2.13216975
74Nephrogenic diabetes insipidus (HP:0009806)2.13044081
75Increased intramyocellular lipid droplets (HP:0012240)2.09997378
76Bowel incontinence (HP:0002607)2.09838657
77Congenital, generalized hypertrichosis (HP:0004540)2.09720462
78Acute encephalopathy (HP:0006846)2.09463883
79Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.09053976
80CNS hypomyelination (HP:0003429)2.08376872
81Abnormality of chromosome stability (HP:0003220)2.08089840
82Abnormality of T cell number (HP:0011839)2.07907531
83Petechiae (HP:0000967)2.05373191
84Progressive macrocephaly (HP:0004481)2.05214495
85Abnormality of the fovea (HP:0000493)2.04562581
86Long nose (HP:0003189)1.98432388
87Abnormal large intestine physiology (HP:0012700)1.98312206
88IgA deficiency (HP:0002720)1.98120720
89Cystic liver disease (HP:0006706)1.96691414
90Morphological abnormality of the pyramidal tract (HP:0002062)1.96517381
91Occipital encephalocele (HP:0002085)1.94162555
92Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.86359493
93Neutropenia (HP:0001875)1.85775679
94Aplasia/Hypoplasia of the thymus (HP:0010515)1.83705080
95Vaginal atresia (HP:0000148)1.78641347
96Reticulocytopenia (HP:0001896)1.78613993
97Lymphopenia (HP:0001888)1.78113811
98Abnormality of ocular smooth pursuit (HP:0000617)1.77822495
99Abnormality of the renal cortex (HP:0011035)1.77796625
100Myokymia (HP:0002411)1.73884351

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.08834471
2MAP4K25.72750986
3SIK24.91907972
4EPHA34.58501344
5GRK63.12620910
6TLK12.94052086
7NLK2.76130948
8TEC2.65200013
9EPHB12.63694812
10MAP3K132.35640823
11SCYL22.22725659
12PASK2.16781291
13ITK2.12595877
14CAMKK22.07723297
15CAMKK11.99517096
16SIK31.92351267
17MAPKAPK31.79518846
18PINK11.73273410
19MAP3K121.69175718
20BTK1.58448292
21IRAK11.53980608
22MAP4K11.51653199
23MARK31.46491590
24VRK21.45468340
25FGFR41.40991414
26ADRBK21.30376991
27PDK21.08742977
28MYLK1.07806449
29IKBKB0.98897499
30HCK0.96139207
31ALK0.94999871
32MAPK130.85975100
33FER0.84631083
34LYN0.82513760
35DYRK20.80218512
36PLK40.79271719
37MAP3K140.75455109
38SYK0.73890839
39CDK80.67947801
40HIPK20.66949618
41SIK10.65022914
42TBK10.61343136
43CDK190.60252842
44LCK0.57044889
45TAOK30.56191600
46PAK60.55458245
47PIM10.55264466
48TESK20.54031577
49MAP3K110.53233459
50BMPR1B0.51604280
51JAK10.50924014
52OXSR10.49728498
53TYK20.46233496
54PAK30.45789880
55FES0.45107512
56FGFR30.44149354
57ZAP700.43443671
58RIPK40.40922843
59TNK20.38228513
60DAPK10.37779908
61EPHA40.36654203
62MINK10.36086146
63RPS6KB20.33999192
64MAPK120.32811251
65MAP3K10.31597434
66RPS6KA50.31516088
67PTK2B0.31195181
68PRKAA10.31112056
69NEK20.29957186
70NEK60.29377479
71ERBB20.29278839
72IGF1R0.28907597
73ADRBK10.28294437
74NEK90.26601719
75CHUK0.25751962
76ACVR1B0.25262028
77DAPK20.23907421
78RAF10.23863382
79STK38L0.23846375
80ATR0.23521652
81PIM20.21832361
82FRK0.21692746
83INSRR0.21593447
84MAPKAPK20.19878423
85CSF1R0.19342473
86IRAK30.19077879
87CDK40.18919981
88VRK10.18910769
89KDR0.15849194
90CHEK20.15656186
91CAMK2A0.15518825
92WNK30.14962815
93CDK50.13860552
94CSNK1A10.13251662
95SRPK10.13233251
96ABL10.12249729
97BRSK20.12078901
98MAP2K20.11877419
99PRKAA20.11736982
100PRKACA0.11065789

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.13512983
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.55402943
3Ribosome_Homo sapiens_hsa030103.10424769
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.03647212
5Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.82958512
6Oxidative phosphorylation_Homo sapiens_hsa001902.81552780
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.75596461
8Homologous recombination_Homo sapiens_hsa034402.73793948
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.69090926
10Non-homologous end-joining_Homo sapiens_hsa034502.68677432
11Linoleic acid metabolism_Homo sapiens_hsa005912.52882943
12Primary immunodeficiency_Homo sapiens_hsa053402.50344106
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.24647458
14Parkinsons disease_Homo sapiens_hsa050122.04527938
15Ether lipid metabolism_Homo sapiens_hsa005651.99023947
16Phototransduction_Homo sapiens_hsa047441.77974520
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.72834707
18Caffeine metabolism_Homo sapiens_hsa002321.72090688
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70111044
20Autoimmune thyroid disease_Homo sapiens_hsa053201.66753472
21Allograft rejection_Homo sapiens_hsa053301.66106625
22Huntingtons disease_Homo sapiens_hsa050161.65745236
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.64689178
24Mismatch repair_Homo sapiens_hsa034301.64259495
25Alzheimers disease_Homo sapiens_hsa050101.62868232
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.58618767
27Graft-versus-host disease_Homo sapiens_hsa053321.46575670
28Fat digestion and absorption_Homo sapiens_hsa049751.33958367
29Cardiac muscle contraction_Homo sapiens_hsa042601.33016377
30Pyrimidine metabolism_Homo sapiens_hsa002401.32802032
31Asthma_Homo sapiens_hsa053101.29678198
32Selenocompound metabolism_Homo sapiens_hsa004501.26209217
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19165138
34T cell receptor signaling pathway_Homo sapiens_hsa046601.12573432
35Nitrogen metabolism_Homo sapiens_hsa009101.06668881
36Fanconi anemia pathway_Homo sapiens_hsa034601.04167295
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03372284
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99836850
39Rheumatoid arthritis_Homo sapiens_hsa053230.99005613
40Type I diabetes mellitus_Homo sapiens_hsa049400.97464817
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95679558
42NF-kappa B signaling pathway_Homo sapiens_hsa040640.91541748
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88896578
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87943838
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.87087277
46Olfactory transduction_Homo sapiens_hsa047400.86393323
47Viral myocarditis_Homo sapiens_hsa054160.85576871
48Purine metabolism_Homo sapiens_hsa002300.83365781
49Arachidonic acid metabolism_Homo sapiens_hsa005900.83324151
50RNA degradation_Homo sapiens_hsa030180.80760362
51Salivary secretion_Homo sapiens_hsa049700.79067089
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.78209667
53Taste transduction_Homo sapiens_hsa047420.73184027
54Systemic lupus erythematosus_Homo sapiens_hsa053220.71266584
55Protein export_Homo sapiens_hsa030600.69362553
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68232019
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68166197
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67111658
59Ovarian steroidogenesis_Homo sapiens_hsa049130.64153176
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.63260049
61Hematopoietic cell lineage_Homo sapiens_hsa046400.62803437
62Platelet activation_Homo sapiens_hsa046110.61049913
63GABAergic synapse_Homo sapiens_hsa047270.59504990
64Regulation of autophagy_Homo sapiens_hsa041400.57290042
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56628243
66Staphylococcus aureus infection_Homo sapiens_hsa051500.55203864
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55057955
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.54838814
69Chemokine signaling pathway_Homo sapiens_hsa040620.52938850
70Glycerolipid metabolism_Homo sapiens_hsa005610.52876443
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.52420656
72Measles_Homo sapiens_hsa051620.51056877
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50464159
74Serotonergic synapse_Homo sapiens_hsa047260.45583369
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42738329
76Acute myeloid leukemia_Homo sapiens_hsa052210.41946332
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40242144
78Antigen processing and presentation_Homo sapiens_hsa046120.37668099
79p53 signaling pathway_Homo sapiens_hsa041150.37555955
80Collecting duct acid secretion_Homo sapiens_hsa049660.36581401
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.36539814
82DNA replication_Homo sapiens_hsa030300.35673329
83Morphine addiction_Homo sapiens_hsa050320.34052658
84Pancreatic secretion_Homo sapiens_hsa049720.33105441
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32455985
86Metabolic pathways_Homo sapiens_hsa011000.29083017
87Nicotine addiction_Homo sapiens_hsa050330.27855446
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.27120688
89ABC transporters_Homo sapiens_hsa020100.25916338
90Tuberculosis_Homo sapiens_hsa051520.22626346
91Gastric acid secretion_Homo sapiens_hsa049710.22074847
92Chemical carcinogenesis_Homo sapiens_hsa052040.20764103
93Toxoplasmosis_Homo sapiens_hsa051450.19483063
94Basal transcription factors_Homo sapiens_hsa030220.18991220
95Tryptophan metabolism_Homo sapiens_hsa003800.18906951
96Glutamatergic synapse_Homo sapiens_hsa047240.16841074
97Oxytocin signaling pathway_Homo sapiens_hsa049210.16020382
98Phagosome_Homo sapiens_hsa041450.15904697
99Retinol metabolism_Homo sapiens_hsa008300.15855380
100Circadian entrainment_Homo sapiens_hsa047130.14837506

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