H2BFS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* innate immune response in mucosa (GO:0002227)7.50867497
2DNA replication-dependent nucleosome organization (GO:0034723)7.22282310
3DNA replication-dependent nucleosome assembly (GO:0006335)7.22282310
4nuclear pore complex assembly (GO:0051292)7.07762345
5nuclear pore organization (GO:0006999)6.42145641
6* mucosal immune response (GO:0002385)6.15043921
7nucleosome assembly (GO:0006334)5.89544677
8* antibacterial humoral response (GO:0019731)5.66804776
9* organ or tissue specific immune response (GO:0002251)5.53665223
10pore complex assembly (GO:0046931)5.48001155
11DNA unwinding involved in DNA replication (GO:0006268)5.26872647
12* antimicrobial humoral response (GO:0019730)5.10735152
13protein-DNA complex assembly (GO:0065004)5.07989950
14chromatin assembly (GO:0031497)5.03187546
15DNA strand elongation involved in DNA replication (GO:0006271)4.90494505
16nucleosome organization (GO:0034728)4.88771235
17mitotic chromosome condensation (GO:0007076)4.82330811
18DNA strand elongation (GO:0022616)4.73899871
19DNA replication initiation (GO:0006270)4.60653660
20protein localization to chromosome, centromeric region (GO:0071459)4.53189315
21regulation of sister chromatid cohesion (GO:0007063)4.49086638
22chromatin assembly or disassembly (GO:0006333)4.47451827
23telomere maintenance via semi-conservative replication (GO:0032201)4.43535252
24protein-DNA complex subunit organization (GO:0071824)4.33641764
25regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.13368919
26negative regulation of thymocyte apoptotic process (GO:0070244)3.98516034
27mitotic sister chromatid segregation (GO:0000070)3.98246401
28CENP-A containing nucleosome assembly (GO:0034080)3.93699438
29V(D)J recombination (GO:0033151)3.93233237
30sister chromatid segregation (GO:0000819)3.92369963
31negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.87394626
32telomere maintenance via recombination (GO:0000722)3.82638538
33regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.81634543
34mitotic recombination (GO:0006312)3.71404016
35chromatin remodeling at centromere (GO:0031055)3.68223089
36mitotic nuclear envelope disassembly (GO:0007077)3.66518201
37regulation of histone H3-K9 methylation (GO:0051570)3.60947705
38nucleobase-containing small molecule interconversion (GO:0015949)3.52233593
39protein localization to kinetochore (GO:0034501)3.45381063
40DNA duplex unwinding (GO:0032508)3.41940488
41DNA synthesis involved in DNA repair (GO:0000731)3.40022580
42DNA replication checkpoint (GO:0000076)3.39359414
43regulation of translational fidelity (GO:0006450)3.35620948
44positive regulation of chromosome segregation (GO:0051984)3.34326559
45membrane disassembly (GO:0030397)3.32360934
46nuclear envelope disassembly (GO:0051081)3.32360934
47DNA geometric change (GO:0032392)3.28570370
48regulation of chromosome segregation (GO:0051983)3.27558263
49mitotic metaphase plate congression (GO:0007080)3.22071991
50mitotic sister chromatid cohesion (GO:0007064)3.19824795
51viral mRNA export from host cell nucleus (GO:0046784)3.17311424
52formation of translation preinitiation complex (GO:0001731)3.14325731
53nucleotide-excision repair, DNA gap filling (GO:0006297)3.12560703
54non-recombinational repair (GO:0000726)3.10440469
55double-strand break repair via nonhomologous end joining (GO:0006303)3.10440469
56chromosome condensation (GO:0030261)3.07541554
57regulation of centrosome cycle (GO:0046605)3.06149374
58ribosome assembly (GO:0042255)3.05991350
59positive regulation of mitotic sister chromatid separation (GO:1901970)2.99717467
60positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.99717467
61positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.99717467
62DNA conformation change (GO:0071103)2.98559428
63meiotic chromosome segregation (GO:0045132)2.97250433
64DNA replication-independent nucleosome assembly (GO:0006336)2.97095230
65DNA replication-independent nucleosome organization (GO:0034724)2.97095230
66cellular protein complex localization (GO:0034629)2.96837847
67deoxyribonucleotide biosynthetic process (GO:0009263)2.93924179
68mitochondrial DNA metabolic process (GO:0032042)2.93535202
69rRNA transcription (GO:0009303)2.93065239
70telomere maintenance via telomere lengthening (GO:0010833)2.91631612
71metaphase plate congression (GO:0051310)2.90967066
72microtubule depolymerization (GO:0007019)2.88422408
73DNA packaging (GO:0006323)2.87637494
74regulation of centriole replication (GO:0046599)2.84887081
75ribosomal small subunit biogenesis (GO:0042274)2.83968570
76telomere organization (GO:0032200)2.83859767
77telomere maintenance (GO:0000723)2.82688329
78regulation of megakaryocyte differentiation (GO:0045652)2.81835083
79folic acid-containing compound biosynthetic process (GO:0009396)2.81723501
80somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.81264532
81somatic cell DNA recombination (GO:0016444)2.81264532
82histone exchange (GO:0043486)2.77198799
83spindle checkpoint (GO:0031577)2.75054228
84response to UV-C (GO:0010225)2.74556077
85chromosome segregation (GO:0007059)2.74295484
86negative regulation of chromosome segregation (GO:0051985)2.73664444
87protein complex localization (GO:0031503)2.72764697
88DNA topological change (GO:0006265)2.72721331
89kinetochore organization (GO:0051383)2.70951575
90regulation of mitotic sister chromatid separation (GO:0010965)2.69609679
91regulation of mitotic sister chromatid segregation (GO:0033047)2.69609679
92regulation of sister chromatid segregation (GO:0033045)2.69609679
93regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.68839974
94regulation of mitotic metaphase/anaphase transition (GO:0030071)2.68839974
95maturation of SSU-rRNA (GO:0030490)2.65903858
96mitotic spindle checkpoint (GO:0071174)2.64223334
97regulation of DNA damage checkpoint (GO:2000001)2.63932127
98mitotic spindle assembly checkpoint (GO:0007094)2.63778549
99mitotic cell cycle (GO:0000278)2.62559104
100DNA ligation (GO:0006266)2.62037219

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.66850739
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.42281233
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.91391368
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.27478474
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.05645931
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.36935983
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.32618100
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.24042150
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.22128655
10MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08293748
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06260254
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03417792
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03046090
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.00657824
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.00615616
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse13.1010454
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90374139
18HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.89276033
19HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87970906
20AR_21909140_ChIP-Seq_LNCAP_Human1.80335119
21CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.75528440
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75348726
23SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.74525600
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.67170634
25ERG_20887958_ChIP-Seq_HPC-7_Mouse1.67021959
26THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63971436
27VDR_23849224_ChIP-Seq_CD4+_Human1.56923944
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.56022780
29ELK1_19687146_ChIP-ChIP_HELA_Human1.51818469
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49632475
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.49379758
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46784249
33ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46195700
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.46068604
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.45091286
36DCP1A_22483619_ChIP-Seq_HELA_Human1.44856971
37SOX2_16153702_ChIP-ChIP_HESCs_Human1.41276677
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40810770
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38595580
40DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38025953
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.37703872
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34421007
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.32842234
44EST1_17652178_ChIP-ChIP_JURKAT_Human1.32839499
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31022440
46FOXP3_21729870_ChIP-Seq_TREG_Human1.30764474
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30046493
48XRN2_22483619_ChIP-Seq_HELA_Human1.29765444
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29241489
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24029036
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23519886
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21044011
53GATA1_22025678_ChIP-Seq_K562_Human1.18970905
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18833006
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17124207
56MYC_22102868_ChIP-Seq_BL_Human1.15890044
57IRF1_19129219_ChIP-ChIP_H3396_Human1.15506756
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15177640
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15147269
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12867957
61SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11850088
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09840238
63ZNF263_19887448_ChIP-Seq_K562_Human1.08438147
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05379415
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04938995
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04543488
67PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.03193996
68ETS1_22383799_ChIP-Seq_G1ME_Mouse1.02798258
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02253170
70TTF2_22483619_ChIP-Seq_HELA_Human1.00639481
71KDM5A_27292631_Chip-Seq_BREAST_Human0.99780780
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97028901
73MYC_18940864_ChIP-ChIP_HL60_Human0.97013550
74BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96855568
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96695608
76GABP_19822575_ChIP-Seq_HepG2_Human0.96095490
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95956141
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95422094
79TFEB_21752829_ChIP-Seq_HELA_Human0.94064193
80ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.93671625
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93392583
82VDR_21846776_ChIP-Seq_THP-1_Human0.93326951
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90739092
84STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90235561
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89715547
86CIITA_25753668_ChIP-Seq_RAJI_Human0.88854067
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88331573
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88144549
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87686401
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85801257
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84943055
92NANOG_18555785_ChIP-Seq_MESCs_Mouse0.84066276
93SRF_21415370_ChIP-Seq_HL-1_Mouse0.83904207
94KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83829589
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83708327
96PKCTHETA_26484144_Chip-Seq_BREAST_Human0.83308202
97NANOG_16153702_ChIP-ChIP_HESCs_Human0.82877316
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.80921896
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.77867399
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.77278434

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.67102847
2MP0008057_abnormal_DNA_replication4.14983250
3MP0003111_abnormal_nucleus_morphology3.91960719
4MP0003077_abnormal_cell_cycle3.51863002
5MP0004957_abnormal_blastocyst_morpholog3.41219371
6MP0003693_abnormal_embryo_hatching3.38126683
7MP0002877_abnormal_melanocyte_morpholog2.93292010
8MP0010352_gastrointestinal_tract_polyps2.81508684
9MP0009697_abnormal_copulation2.76568756
10MP0008058_abnormal_DNA_repair2.60998832
11MP0008007_abnormal_cellular_replicative2.49225799
12MP0010307_abnormal_tumor_latency2.36945185
13MP0002009_preneoplasia2.31328112
14MP0008932_abnormal_embryonic_tissue2.30613930
15MP0002396_abnormal_hematopoietic_system2.23536090
16MP0005464_abnormal_platelet_physiology2.22519969
17MP0003786_premature_aging2.03506096
18MP0004808_abnormal_hematopoietic_stem1.97915910
19MP0003763_abnormal_thymus_physiology1.96838559
20MP0001661_extended_life_span1.93147470
21MP0004185_abnormal_adipocyte_glucose1.91173223
22MP0010234_abnormal_vibrissa_follicle1.89252810
23MP0000350_abnormal_cell_proliferation1.73691163
24MP0002166_altered_tumor_susceptibility1.71140819
25MP0000490_abnormal_crypts_of1.68413039
26MP0001730_embryonic_growth_arrest1.48730772
27MP0000703_abnormal_thymus_morphology1.47471468
28MP0000358_abnormal_cell_content/1.47002098
29MP0002019_abnormal_tumor_incidence1.46721181
30MP0002006_tumorigenesis1.40531225
31MP0000313_abnormal_cell_death1.36300990
32MP0006035_abnormal_mitochondrial_morpho1.34136097
33MP0004381_abnormal_hair_follicle1.30836531
34MP0003656_abnormal_erythrocyte_physiolo1.28242221
35MP0002398_abnormal_bone_marrow1.27810211
36MP0001697_abnormal_embryo_size1.27034597
37MP0005501_abnormal_skin_physiology1.26552112
38MP0009333_abnormal_splenocyte_physiolog1.23872366
39MP0000465_gastrointestinal_hemorrhage1.23389955
40MP0001835_abnormal_antigen_presentation1.23108892
41MP0002722_abnormal_immune_system1.22270470
42MP0002086_abnormal_extraembryonic_tissu1.21375238
43MP0001986_abnormal_taste_sensitivity1.21013973
44MP0005076_abnormal_cell_differentiation1.20015035
45MP0002080_prenatal_lethality1.19936985
46MP0002163_abnormal_gland_morphology1.19500280
47MP0005451_abnormal_body_composition1.16385296
48MP0003705_abnormal_hypodermis_morpholog1.15580952
49MP0001672_abnormal_embryogenesis/_devel1.12710893
50MP0005380_embryogenesis_phenotype1.12710893
51MP0003566_abnormal_cell_adhesion1.08607886
52MP0003718_maternal_effect1.07027986
53MP0000015_abnormal_ear_pigmentation1.05433360
54MP0005083_abnormal_biliary_tract1.05345489
55MP0003950_abnormal_plasma_membrane1.05184767
56MP0000537_abnormal_urethra_morphology1.05045543
57MP0003984_embryonic_growth_retardation1.04058371
58MP0004233_abnormal_muscle_weight1.00335590
59MP0000689_abnormal_spleen_morphology0.98087986
60MP0002088_abnormal_embryonic_growth/wei0.97669712
61MP0004947_skin_inflammation0.97346013
62MP0002084_abnormal_developmental_patter0.94943252
63MP0003806_abnormal_nucleotide_metabolis0.94009440
64MP0002160_abnormal_reproductive_system0.93492725
65MP0000858_altered_metastatic_potential0.91822119
66MP0002429_abnormal_blood_cell0.91475564
67MP0002132_abnormal_respiratory_system0.91089658
68MP0001216_abnormal_epidermal_layer0.90098720
69MP0005397_hematopoietic_system_phenotyp0.89975684
70MP0001545_abnormal_hematopoietic_system0.89975684
71MP0004134_abnormal_chest_morphology0.88133569
72MP0005384_cellular_phenotype0.87923626
73MP0001849_ear_inflammation0.87474873
74MP0002060_abnormal_skin_morphology0.83240779
75MP0005621_abnormal_cell_physiology0.82533150
76MP0002085_abnormal_embryonic_tissue0.82098475
77MP0002098_abnormal_vibrissa_morphology0.82096197
78MP0001929_abnormal_gametogenesis0.81058021
79MP0001873_stomach_inflammation0.80877719
80MP0000627_abnormal_mammary_gland0.76285214
81MP0002210_abnormal_sex_determination0.75354491
82MP0003221_abnormal_cardiomyocyte_apopto0.74035489
83MP0001191_abnormal_skin_condition0.72028858
84MP0001243_abnormal_dermal_layer0.71552359
85MP0001915_intracranial_hemorrhage0.70865546
86MP0004147_increased_porphyrin_level0.69522250
87MP0000716_abnormal_immune_system0.68871379
88MP0005220_abnormal_exocrine_pancreas0.67711241
89MP0009278_abnormal_bone_marrow0.67597730
90MP0009379_abnormal_foot_pigmentation0.66532916
91MP0010155_abnormal_intestine_physiology0.66211863
92MP0000733_abnormal_muscle_development0.65647266
93MP0000377_abnormal_hair_follicle0.65475210
94MP0001727_abnormal_embryo_implantation0.65160056
95MP0002092_abnormal_eye_morphology0.65122584
96MP0000685_abnormal_immune_system0.64153228
97MP0009931_abnormal_skin_appearance0.63136906
98MP0005075_abnormal_melanosome_morpholog0.62914295
99MP0005410_abnormal_fertilization0.62169924
100MP0001145_abnormal_male_reproductive0.62114016

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.07619346
2Chromsome breakage (HP:0040012)5.42023005
3Increased mean platelet volume (HP:0011877)3.73032112
4Abnormality of the preputium (HP:0100587)3.64105334
5B lymphocytopenia (HP:0010976)3.53728790
6Abnormal platelet volume (HP:0011876)3.41508757
7Abnormality of chromosome stability (HP:0003220)3.38011012
8Aplasia/Hypoplasia of the uvula (HP:0010293)3.29759829
9Cutaneous melanoma (HP:0012056)3.23925700
10Reticulocytopenia (HP:0001896)3.05845263
11Thyroiditis (HP:0100646)3.05707017
12Abnormality of B cell number (HP:0010975)3.04143806
13Myelodysplasia (HP:0002863)2.96591014
14Petechiae (HP:0000967)2.89871182
15Abnormality of the carotid arteries (HP:0005344)2.84079007
16Meckel diverticulum (HP:0002245)2.81005514
17Autoimmune hemolytic anemia (HP:0001890)2.80617756
18IgA deficiency (HP:0002720)2.74813888
19Aplasia/Hypoplasia of the sacrum (HP:0008517)2.73835003
20Abnormality of the ileum (HP:0001549)2.71943008
21IgM deficiency (HP:0002850)2.71741931
22Abnormality of oral frenula (HP:0000190)2.66524481
23Ankyloglossia (HP:0010296)2.66253556
24Clubbing of toes (HP:0100760)2.65560055
25Duodenal stenosis (HP:0100867)2.65301918
26Small intestinal stenosis (HP:0012848)2.65301918
27Squamous cell carcinoma (HP:0002860)2.63866784
28Combined immunodeficiency (HP:0005387)2.48011737
29Prolonged bleeding time (HP:0003010)2.45932046
30Colitis (HP:0002583)2.43769580
31Entropion (HP:0000621)2.38843473
32Severe combined immunodeficiency (HP:0004430)2.38285269
33Progressive external ophthalmoplegia (HP:0000590)2.36394197
34Menorrhagia (HP:0000132)2.32909985
35Birth length less than 3rd percentile (HP:0003561)2.29621531
36Dyschromatopsia (HP:0007641)2.28629669
37Microvesicular hepatic steatosis (HP:0001414)2.27473861
38Recurrent viral infections (HP:0004429)2.27077979
39Orthostatic hypotension (HP:0001278)2.22496698
40Nephroblastoma (Wilms tumor) (HP:0002667)2.22329992
41Abnormality of pyrimidine metabolism (HP:0004353)2.19002883
42Ureteral duplication (HP:0000073)2.18166216
43Leiomyosarcoma (HP:0100243)2.15914765
44Uterine leiomyosarcoma (HP:0002891)2.15914765
45Bone marrow hypocellularity (HP:0005528)2.14244815
46Cafe-au-lait spot (HP:0000957)2.13594027
47Ependymoma (HP:0002888)2.13201272
48Abnormality of the astrocytes (HP:0100707)2.12973639
49Astrocytoma (HP:0009592)2.12973639
50Insomnia (HP:0100785)2.11872277
51Prominent nose (HP:0000448)2.08343095
52Medulloblastoma (HP:0002885)2.06473348
53Abnormality of DNA repair (HP:0003254)2.04527337
54Embryonal renal neoplasm (HP:0011794)2.02284279
55Poikiloderma (HP:0001029)2.01019368
56Hypergonadotropic hypogonadism (HP:0000815)2.00575198
57Deep philtrum (HP:0002002)2.00395515
58Short thumb (HP:0009778)1.99240661
59Duplicated collecting system (HP:0000081)1.96021204
60Abnormality of the umbilical cord (HP:0010881)1.95901105
61Abnormal umbilical cord blood vessels (HP:0011403)1.95112694
62Single umbilical artery (HP:0001195)1.95112694
63Abnormality of the fetal cardiovascular system (HP:0010948)1.95112694
64Oral leukoplakia (HP:0002745)1.95098728
65Aplasia cutis congenita (HP:0001057)1.94124609
66Hyperacusis (HP:0010780)1.93907228
67Abnormality of cells of the erythroid lineage (HP:0012130)1.93794895
68Syringomyelia (HP:0003396)1.91341082
69Spinal cord lesions (HP:0100561)1.91341082
70Abnormality of the duodenum (HP:0002246)1.91011656
71Rough bone trabeculation (HP:0100670)1.89708064
72Lymphoma (HP:0002665)1.89675669
73Arteriovenous malformation (HP:0100026)1.89600016
74Abnormal foot bone ossification (HP:0010675)1.89145444
75Abnormal platelet function (HP:0011869)1.87811274
76Impaired platelet aggregation (HP:0003540)1.87811274
77Transitional cell carcinoma of the bladder (HP:0006740)1.86693338
78Bladder carcinoma (HP:0002862)1.84244646
79Bladder neoplasm (HP:0009725)1.84244646
80Ectopic kidney (HP:0000086)1.82288110
81Acanthocytosis (HP:0001927)1.81625886
82Short middle phalanx of the 5th finger (HP:0004220)1.81541825
83Hypoplasia of the thymus (HP:0000778)1.81333602
84Abnormality of the parietal bone (HP:0002696)1.79267389
85Insidious onset (HP:0003587)1.77872149
86Termporal pattern (HP:0011008)1.77872149
87Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.77553674
88Osteolytic defects of the hand bones (HP:0009699)1.77439566
89Osteolytic defects of the phalanges of the hand (HP:0009771)1.77439566
90Absent thumb (HP:0009777)1.76781314
91Panhypogammaglobulinemia (HP:0003139)1.76624815
92Abnormality of the renal collecting system (HP:0004742)1.76567578
93Sloping forehead (HP:0000340)1.75435228
94Dysautonomia (HP:0002459)1.75176212
95Prostate neoplasm (HP:0100787)1.73991795
96Acute lymphatic leukemia (HP:0006721)1.73661712
97Gastrointestinal carcinoma (HP:0002672)1.72264705
98Malignant gastrointestinal tract tumors (HP:0006749)1.72264705
99Micronodular cirrhosis (HP:0001413)1.71399375
100Septate vagina (HP:0001153)1.70714351

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK8.27194928
2TLK17.70501080
3VRK13.78502873
4SCYL22.58284217
5RPS6KA52.50217405
6BUB12.45186413
7CDC72.32388742
8PBK2.24623029
9DAPK31.93240757
10NEK11.72425730
11EIF2AK11.69209530
12STK41.65623602
13AURKA1.65074751
14CHEK21.64606224
15NME21.59166526
16IRAK31.56822188
17TTK1.55671417
18BRSK21.51864808
19EIF2AK31.51855473
20EEF2K1.50276066
21SRPK11.43211655
22MST41.40804827
23AURKB1.36859383
24SMG11.30711704
25PIM11.22110111
26CCNB11.06999321
27CDK81.06631243
28WEE11.01663846
29TRIB30.98935942
30BMPR20.97387139
31BRAF0.96092101
32MAP3K80.94444190
33RPS6KB20.93885186
34MST1R0.92915517
35ATR0.92187546
36CDK70.90938790
37PLK40.89429146
38TAF10.85312997
39PKN10.84658464
40TSSK60.84094339
41BTK0.80902154
42PLK10.80738532
43MAP3K120.78243741
44PRPF4B0.78030870
45MAP2K30.74277304
46ILK0.74071595
47BRSK10.68361131
48TESK20.65474224
49PIM20.64118262
50PLK30.63371455
51MAP3K100.62958283
52MAP3K20.62556106
53CAMKK20.60577064
54NEK20.58925838
55RAF10.57230390
56MAPK110.56980830
57CDK60.55954576
58MELK0.54205064
59CHEK10.53742162
60STK30.51804540
61PAK10.50633572
62TTN0.50075935
63RPS6KA40.49641126
64AKT20.48042913
65PIK3CG0.47920940
66PKN20.45984726
67STK160.45661759
68ATM0.42727391
69CDK40.38667265
70CDK120.38420824
71PRKCI0.36106571
72ICK0.35621236
73IRAK20.34903407
74BMX0.33686622
75KDR0.33657913
76CLK10.33608510
77CDK90.33525599
78PAK40.32554165
79EIF2AK20.30980455
80STK240.30664858
81TEC0.30608722
82ABL20.28912054
83PRKAA10.26744442
84PAK20.26265540
85NLK0.26062717
86CSNK1G30.24650220
87CDK20.23923164
88BLK0.22158172
89CDK10.21763743
90DAPK10.21661593
91KSR20.21307122
92GRK60.20811856
93TAOK20.20557343
94ERBB30.19985704
95HCK0.19960570
96CSNK1A1L0.19122524
97JAK20.18177421
98MET0.18136129
99NEK90.17644160
100CSNK1G10.15826190

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053229.42477288
2Alcoholism_Homo sapiens_hsa050346.87274138
3DNA replication_Homo sapiens_hsa030303.68830435
4Viral carcinogenesis_Homo sapiens_hsa052033.43522998
5Mismatch repair_Homo sapiens_hsa034302.85214191
6Cell cycle_Homo sapiens_hsa041102.15693320
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.12457399
8Nucleotide excision repair_Homo sapiens_hsa034201.92273530
9Non-homologous end-joining_Homo sapiens_hsa034501.89656939
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81985421
11Homologous recombination_Homo sapiens_hsa034401.80549294
12Fanconi anemia pathway_Homo sapiens_hsa034601.73271356
13Base excision repair_Homo sapiens_hsa034101.62950479
14Transcriptional misregulation in cancer_Homo sapiens_hsa052021.47583294
15Pyrimidine metabolism_Homo sapiens_hsa002401.39660472
16RNA transport_Homo sapiens_hsa030131.35576441
17Ribosome_Homo sapiens_hsa030101.34180034
18Proteasome_Homo sapiens_hsa030501.17780848
19p53 signaling pathway_Homo sapiens_hsa041151.16169404
20RNA polymerase_Homo sapiens_hsa030201.14832784
21Thyroid cancer_Homo sapiens_hsa052161.14681242
22One carbon pool by folate_Homo sapiens_hsa006701.12059607
23Non-small cell lung cancer_Homo sapiens_hsa052231.00542966
24Spliceosome_Homo sapiens_hsa030400.94317303
25Bladder cancer_Homo sapiens_hsa052190.87950252
26Pancreatic cancer_Homo sapiens_hsa052120.87730526
27Sulfur relay system_Homo sapiens_hsa041220.86439335
28Sulfur metabolism_Homo sapiens_hsa009200.85359517
29Chronic myeloid leukemia_Homo sapiens_hsa052200.84325191
30Purine metabolism_Homo sapiens_hsa002300.79404438
31Basal transcription factors_Homo sapiens_hsa030220.77066862
32N-Glycan biosynthesis_Homo sapiens_hsa005100.77030789
33Primary immunodeficiency_Homo sapiens_hsa053400.73601357
34Pentose phosphate pathway_Homo sapiens_hsa000300.71906055
35Small cell lung cancer_Homo sapiens_hsa052220.71606302
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63473064
37Glioma_Homo sapiens_hsa052140.62853669
38Biosynthesis of amino acids_Homo sapiens_hsa012300.60979975
39Selenocompound metabolism_Homo sapiens_hsa004500.59910149
40Colorectal cancer_Homo sapiens_hsa052100.59324553
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59238927
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58439388
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57841262
44Endometrial cancer_Homo sapiens_hsa052130.57604804
45Vitamin B6 metabolism_Homo sapiens_hsa007500.54617289
46Platelet activation_Homo sapiens_hsa046110.54234369
47mRNA surveillance pathway_Homo sapiens_hsa030150.53589231
48HTLV-I infection_Homo sapiens_hsa051660.50421317
49Melanoma_Homo sapiens_hsa052180.49152736
50Apoptosis_Homo sapiens_hsa042100.48359640
51Epstein-Barr virus infection_Homo sapiens_hsa051690.47829650
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46772961
53MicroRNAs in cancer_Homo sapiens_hsa052060.46549916
54Shigellosis_Homo sapiens_hsa051310.44705173
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43689816
56RNA degradation_Homo sapiens_hsa030180.43515983
57Hepatitis B_Homo sapiens_hsa051610.42582481
58B cell receptor signaling pathway_Homo sapiens_hsa046620.41960421
59Acute myeloid leukemia_Homo sapiens_hsa052210.41686904
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41363888
61Herpes simplex infection_Homo sapiens_hsa051680.40896630
62Prostate cancer_Homo sapiens_hsa052150.40584183
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.40514416
64Hematopoietic cell lineage_Homo sapiens_hsa046400.40209552
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39869352
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.38466532
67Oocyte meiosis_Homo sapiens_hsa041140.38218439
68Measles_Homo sapiens_hsa051620.37052586
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35949665
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35191724
71Galactose metabolism_Homo sapiens_hsa000520.34873024
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34860337
73Glutathione metabolism_Homo sapiens_hsa004800.34035103
74TGF-beta signaling pathway_Homo sapiens_hsa043500.32192663
75Carbon metabolism_Homo sapiens_hsa012000.29306635
76Inositol phosphate metabolism_Homo sapiens_hsa005620.26451730
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24948518
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24792333
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23439045
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.21441131
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20761348
82Legionellosis_Homo sapiens_hsa051340.20042085
83Folate biosynthesis_Homo sapiens_hsa007900.19771621
84Huntingtons disease_Homo sapiens_hsa050160.19348255
85T cell receptor signaling pathway_Homo sapiens_hsa046600.19031257
86mTOR signaling pathway_Homo sapiens_hsa041500.18145598
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.14737400
88Fatty acid elongation_Homo sapiens_hsa000620.13990685
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12404576
90Sphingolipid metabolism_Homo sapiens_hsa006000.11954853
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.11578025
92HIF-1 signaling pathway_Homo sapiens_hsa040660.11491278
93Pathways in cancer_Homo sapiens_hsa052000.11380711
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.10852114
95Vibrio cholerae infection_Homo sapiens_hsa051100.10438341
96Pyruvate metabolism_Homo sapiens_hsa006200.10144624
97ErbB signaling pathway_Homo sapiens_hsa040120.10032680
98FoxO signaling pathway_Homo sapiens_hsa040680.09286330
99Influenza A_Homo sapiens_hsa051640.08712922
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.07738135

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