H3F3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.24227916
2translational termination (GO:0006415)6.02030651
3ribosomal small subunit assembly (GO:0000028)5.77706278
4sequestering of actin monomers (GO:0042989)5.70508361
5ribosomal small subunit biogenesis (GO:0042274)5.48463261
6pyrimidine nucleobase catabolic process (GO:0006208)5.32836568
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.27529927
8cotranslational protein targeting to membrane (GO:0006613)5.18092407
9protein targeting to ER (GO:0045047)5.15021741
10translational elongation (GO:0006414)5.11229988
11establishment of protein localization to endoplasmic reticulum (GO:0072599)4.92117519
12nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.88541741
13protein localization to endoplasmic reticulum (GO:0070972)4.80103516
14viral life cycle (GO:0019058)4.77172487
15cellular protein complex disassembly (GO:0043624)4.70647440
16translational initiation (GO:0006413)4.57824851
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.50517999
18maturation of SSU-rRNA (GO:0030490)4.46301666
19protein complex disassembly (GO:0043241)4.35949331
20ATP synthesis coupled proton transport (GO:0015986)4.30174112
21energy coupled proton transport, down electrochemical gradient (GO:0015985)4.30174112
22DNA strand elongation involved in DNA replication (GO:0006271)4.24107565
23leukocyte migration involved in inflammatory response (GO:0002523)4.22788804
24protein neddylation (GO:0045116)4.18868884
25DNA unwinding involved in DNA replication (GO:0006268)4.15611819
26telomere maintenance via semi-conservative replication (GO:0032201)4.11874074
27macromolecular complex disassembly (GO:0032984)4.07826944
28DNA strand elongation (GO:0022616)4.02383015
29ribosomal large subunit biogenesis (GO:0042273)3.95972595
30negative regulation of RNA splicing (GO:0033119)3.92584634
31respiratory burst (GO:0045730)3.89904412
32nucleobase catabolic process (GO:0046113)3.88811357
33nuclear-transcribed mRNA catabolic process (GO:0000956)3.75481848
34mitotic recombination (GO:0006312)3.70050616
35establishment of protein localization to mitochondrial membrane (GO:0090151)3.68434719
36telomere maintenance via recombination (GO:0000722)3.68247601
37CENP-A containing nucleosome assembly (GO:0034080)3.64309258
38mRNA catabolic process (GO:0006402)3.55364513
39deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.54059743
40DNA replication initiation (GO:0006270)3.51907443
41negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.49714749
42chromatin remodeling at centromere (GO:0031055)3.46497783
43DNA deamination (GO:0045006)3.43649547
44positive regulation by symbiont of host defense response (GO:0052509)3.42862263
45modulation by symbiont of host defense response (GO:0052031)3.42862263
46modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.42862263
47modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.42862263
48positive regulation by organism of defense response of other organism involved in symbiotic interact3.42862263
49modulation by symbiont of host immune response (GO:0052553)3.42862263
50kinetochore organization (GO:0051383)3.39708374
51nucleotide-excision repair, DNA gap filling (GO:0006297)3.39430584
52chaperone-mediated protein transport (GO:0072321)3.38480528
53protein targeting to membrane (GO:0006612)3.37288812
54DNA topological change (GO:0006265)3.35902541
55RNA catabolic process (GO:0006401)3.35764348
56pyrimidine nucleotide catabolic process (GO:0006244)3.33728653
57negative regulation of cell killing (GO:0031342)3.31283515
58negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.31283515
59establishment of integrated proviral latency (GO:0075713)3.30341907
60neural tube formation (GO:0001841)3.29098457
61translation (GO:0006412)3.28278425
62* DNA replication-independent nucleosome assembly (GO:0006336)3.21539817
63* DNA replication-independent nucleosome organization (GO:0034724)3.21539817
64activated T cell proliferation (GO:0050798)3.16108598
65negative regulation of mRNA processing (GO:0050686)3.16105695
66DNA replication checkpoint (GO:0000076)3.15804495
67telomere maintenance via telomere lengthening (GO:0010833)3.14978544
68DNA replication-dependent nucleosome organization (GO:0034723)3.13986268
69DNA replication-dependent nucleosome assembly (GO:0006335)3.13986268
70epithelial cilium movement (GO:0003351)3.13688966
71formation of translation preinitiation complex (GO:0001731)3.13458920
72protein localization to kinetochore (GO:0034501)3.12640096
73behavioral response to nicotine (GO:0035095)3.11904199
74spinal cord association neuron differentiation (GO:0021527)3.11252040
75forebrain neuron differentiation (GO:0021879)3.11076378
76neutrophil activation involved in immune response (GO:0002283)3.09469795
77termination of RNA polymerase II transcription (GO:0006369)3.09364442
78ribonucleoprotein complex biogenesis (GO:0022613)3.08413168
79protein localization to chromosome, centromeric region (GO:0071459)3.07082635
80substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.04970563
81substrate-independent telencephalic tangential migration (GO:0021826)3.04970563
82epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.04706938
83mRNA splicing, via spliceosome (GO:0000398)3.04500418
84RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.04500418
85kinetochore assembly (GO:0051382)3.01491447
86RNA splicing, via transesterification reactions (GO:0000375)3.00854154
87attachment of spindle microtubules to kinetochore (GO:0008608)3.00148338
88spliceosomal snRNP assembly (GO:0000387)2.97262135
89histone mRNA metabolic process (GO:0008334)2.95797747
90spliceosomal complex assembly (GO:0000245)2.95231280
91neuron fate determination (GO:0048664)2.94093615
92ATP-dependent chromatin remodeling (GO:0043044)2.92573621
93nonmotile primary cilium assembly (GO:0035058)2.91222776
94mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.90354056
95microglial cell activation (GO:0001774)2.87785710
96histone exchange (GO:0043486)2.86743228
97negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.85266585
98mRNA splice site selection (GO:0006376)2.85039833
99viral mRNA export from host cell nucleus (GO:0046784)2.84931954
100mitotic chromosome condensation (GO:0007076)2.84580999
101respiratory electron transport chain (GO:0022904)2.81923037
102regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.80449079
103translesion synthesis (GO:0019985)2.79110554
104electron transport chain (GO:0022900)2.77926907
105neutrophil mediated immunity (GO:0002446)2.75769489
106DNA ligation (GO:0006266)2.75490430
107neutrophil activation (GO:0042119)2.73741294
108retinal ganglion cell axon guidance (GO:0031290)2.73658253
109mitochondrial respiratory chain complex I assembly (GO:0032981)2.73272757
110NADH dehydrogenase complex assembly (GO:0010257)2.73272757
111mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.73272757
112exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72776202
113detection of other organism (GO:0098543)2.72113474
114anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.71596192
115rRNA processing (GO:0006364)2.70728587
116regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.70345866
117antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.69158774
118transcription-coupled nucleotide-excision repair (GO:0006283)2.68326399
119regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.67200480
120positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.65971644
121somite development (GO:0061053)2.65851777
122alternative mRNA splicing, via spliceosome (GO:0000380)2.62092961
123cilium movement (GO:0003341)2.61577089
124DNA damage response, detection of DNA damage (GO:0042769)2.61524879
125rRNA metabolic process (GO:0016072)2.60978970
126intraciliary transport (GO:0042073)2.60916004
127negative regulation of ligase activity (GO:0051352)2.60857665
128negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.60857665
129nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.59610507
130superoxide anion generation (GO:0042554)2.59228127
131histone H2A acetylation (GO:0043968)2.58883241
132protein complex biogenesis (GO:0070271)2.58505364
133dosage compensation (GO:0007549)2.58224011
134presynaptic membrane organization (GO:0097090)2.58196868
135neurofilament cytoskeleton organization (GO:0060052)2.57738309
136establishment of viral latency (GO:0019043)2.57649022
137axonemal dynein complex assembly (GO:0070286)2.57330212
138positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.57315475
139protein-DNA complex disassembly (GO:0032986)2.57187215
140nucleosome disassembly (GO:0006337)2.57187215
141detection of bacterium (GO:0016045)2.55744502
142mitotic metaphase plate congression (GO:0007080)2.55480224
143neuronal stem cell maintenance (GO:0097150)2.54832943
144pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.54262024
145negative regulation of lymphocyte mediated immunity (GO:0002707)2.52373355
146negative regulation of transcription regulatory region DNA binding (GO:2000678)2.52262542
147olfactory bulb development (GO:0021772)2.50478687
148pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.50373266
149negative regulation of mRNA metabolic process (GO:1903312)2.49816803
150spindle assembly checkpoint (GO:0071173)2.49329631
151DNA-templated transcription, termination (GO:0006353)2.49120922
152regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.48906366
153positive regulation of gastrulation (GO:2000543)2.47282382
154protein localization to chromosome (GO:0034502)2.46269007
155negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.46167145
156negative regulation of sister chromatid segregation (GO:0033046)2.46167145
157negative regulation of mitotic sister chromatid separation (GO:2000816)2.46167145
158negative regulation of mitotic sister chromatid segregation (GO:0033048)2.46167145
159mitotic spindle assembly checkpoint (GO:0007094)2.45994879
160lymphoid progenitor cell differentiation (GO:0002320)2.45617021
161positive regulation of mast cell activation (GO:0033005)2.45346111
162neuron cell-cell adhesion (GO:0007158)2.45337017
163regulation of collateral sprouting (GO:0048670)2.44417947
164mitochondrial respiratory chain complex assembly (GO:0033108)2.44319681
165microtubule depolymerization (GO:0007019)2.39069714
166presynaptic membrane assembly (GO:0097105)2.38281866
167cell differentiation in spinal cord (GO:0021515)2.37966922
168protein localization to cilium (GO:0061512)2.37379080
169positive regulation of gamma-delta T cell activation (GO:0046645)2.36524035
170establishment of mitochondrion localization (GO:0051654)2.34989482

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.00178282
2EZH2_22144423_ChIP-Seq_EOC_Human4.43152112
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.04824898
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.97618358
5* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.72260841
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.67767329
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.61043857
8* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.27079107
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.14266914
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.02783538
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.92451065
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.75629644
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.72983733
14* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.70666069
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.66161808
16XRN2_22483619_ChIP-Seq_HELA_Human2.63804517
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55214410
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.54818058
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.54436011
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53409870
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40878270
22VDR_23849224_ChIP-Seq_CD4+_Human2.40422521
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.37906423
24IRF1_19129219_ChIP-ChIP_H3396_Human2.28499257
25* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25221819
26IGF1R_20145208_ChIP-Seq_DFB_Human2.21881172
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.21439816
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.19465281
29TP63_19390658_ChIP-ChIP_HaCaT_Human2.17141956
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.16796684
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.16203969
32BP1_19119308_ChIP-ChIP_Hs578T_Human2.07577568
33* TTF2_22483619_ChIP-Seq_HELA_Human2.06911582
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.03146869
35FOXP3_21729870_ChIP-Seq_TREG_Human2.02014595
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.99579575
37ELK1_19687146_ChIP-ChIP_HELA_Human1.98850403
38DCP1A_22483619_ChIP-Seq_HELA_Human1.98845901
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.93703014
40ZNF274_21170338_ChIP-Seq_K562_Hela1.93369192
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93341715
42CIITA_25753668_ChIP-Seq_RAJI_Human1.93233949
43* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.92122669
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.90132268
45* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88267546
46MYC_22102868_ChIP-Seq_BL_Human1.87581427
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83796078
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80933073
49GABP_19822575_ChIP-Seq_HepG2_Human1.75854736
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74267560
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.72355515
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71356907
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.69658608
54RNF2_27304074_Chip-Seq_NSC_Mouse1.69169778
55AR_21909140_ChIP-Seq_LNCAP_Human1.64945388
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.64567141
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63764540
58EWS_26573619_Chip-Seq_HEK293_Human1.63714946
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.63210718
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62379274
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60156459
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59864899
63VDR_21846776_ChIP-Seq_THP-1_Human1.57232927
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54711575
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52036008
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50315503
67* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49169335
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48788133
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47837769
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.47005447
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46608214
72REST_21632747_ChIP-Seq_MESCs_Mouse1.45542865
73TAF15_26573619_Chip-Seq_HEK293_Human1.44210590
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41021682
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41021682
76THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39918455
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.36048556
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34411629
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34347940
80FUS_26573619_Chip-Seq_HEK293_Human1.34083135
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32744010
82SPI1_23547873_ChIP-Seq_NB4_Human1.32278677
83SOX2_18555785_ChIP-Seq_MESCs_Mouse1.32123025
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31743274
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31569320
86GATA1_26923725_Chip-Seq_HPCs_Mouse1.30323044
87EZH2_27304074_Chip-Seq_ESCs_Mouse1.27126285
88* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.26508228
89NANOG_16153702_ChIP-ChIP_HESCs_Human1.23946690
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.20302837
91* KDM5A_27292631_Chip-Seq_BREAST_Human1.20073935
92CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19418356
93MYC_18940864_ChIP-ChIP_HL60_Human1.19260392
94IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17281257
95REST_18959480_ChIP-ChIP_MESCs_Mouse1.16859391
96* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16797240
97KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.15312383
98SCL_19346495_ChIP-Seq_HPC-7_Human1.14454318
99YY1_21170310_ChIP-Seq_MESCs_Mouse1.13835717
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.13522281
101NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13196782
102PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12625614
103IRF8_21731497_ChIP-ChIP_J774_Mouse1.12282361
104MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11079944
105ELK1_22589737_ChIP-Seq_MCF10A_Human1.10410892
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08381191
107SRF_21415370_ChIP-Seq_HL-1_Mouse1.08006810
108ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07002355
109VDR_22108803_ChIP-Seq_LS180_Human1.05202538
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04793750
111FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03027980
112KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.02966874
113KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.02966874
114KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.02966874
115POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99572700
116SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99138201
117NOTCH1_21737748_ChIP-Seq_TLL_Human0.99016157
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98311213
119POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98015012
120* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97223145
121TP53_22573176_ChIP-Seq_HFKS_Human0.95859418
122TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95821390
123CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95660908
124TFEB_21752829_ChIP-Seq_HELA_Human0.95248568
125TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94337133
126* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94070225
127POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93095681
128RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92840790
129DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92589707
130JARID2_20064375_ChIP-Seq_MESCs_Mouse0.91287963
131PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91133146
132SUZ12_27294783_Chip-Seq_ESCs_Mouse0.90291806
133VDR_24763502_ChIP-Seq_THP-1_Human0.89663963
134NANOG_20526341_ChIP-Seq_ESCs_Human0.89369441
135KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88637235
136TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88538540
137* UTX_26944678_Chip-Seq_JUKART_Human0.88426415
138SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88003957
139* MYB_26560356_Chip-Seq_TH2_Human0.87885436
140* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85843429
141HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.84757355
142* SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.84125077
143EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.83960003
144SOX2_16153702_ChIP-ChIP_HESCs_Human0.83509603
145SALL1_21062744_ChIP-ChIP_HESCs_Human0.82712350
146BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82553143
147GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82221883
148P300_19829295_ChIP-Seq_ESCs_Human0.82034512

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.86545036
2MP0002653_abnormal_ependyma_morphology3.45813716
3MP0010094_abnormal_chromosome_stability3.36191224
4MP0003787_abnormal_imprinting3.27204567
5MP0004957_abnormal_blastocyst_morpholog2.99637090
6MP0003077_abnormal_cell_cycle2.93688693
7MP0003122_maternal_imprinting2.88284559
8MP0003724_increased_susceptibility_to2.77742980
9MP0003111_abnormal_nucleus_morphology2.77333726
10MP0009379_abnormal_foot_pigmentation2.64945731
11MP0001529_abnormal_vocalization2.61767723
12MP0002822_catalepsy2.58243041
13MP0008007_abnormal_cellular_replicative2.38840935
14MP0008057_abnormal_DNA_replication2.36790723
15MP0008058_abnormal_DNA_repair2.36330545
16MP0003880_abnormal_central_pattern2.29897872
17MP0005394_taste/olfaction_phenotype2.27881731
18MP0005499_abnormal_olfactory_system2.27881731
19MP0001188_hyperpigmentation2.23809870
20MP0003136_yellow_coat_color2.14924946
21MP0008932_abnormal_embryonic_tissue2.06799421
22MP0002396_abnormal_hematopoietic_system2.06768435
23MP0006054_spinal_hemorrhage2.06390755
24MP0003315_abnormal_perineum_morphology2.00736705
25MP0000778_abnormal_nervous_system1.99723163
26MP0000490_abnormal_crypts_of1.90757024
27MP0002102_abnormal_ear_morphology1.88238621
28MP0002938_white_spotting1.86458379
29MP0000537_abnormal_urethra_morphology1.80998577
30MP0010030_abnormal_orbit_morphology1.76460054
31MP0004133_heterotaxia1.76203844
32MP0006276_abnormal_autonomic_nervous1.75092270
33MP0000566_synostosis1.66367898
34MP0005084_abnormal_gallbladder_morpholo1.61130690
35MP0008789_abnormal_olfactory_epithelium1.59834767
36MP0000350_abnormal_cell_proliferation1.58146394
37MP0003567_abnormal_fetal_cardiomyocyte1.57147842
38MP0006292_abnormal_olfactory_placode1.55364340
39MP0004808_abnormal_hematopoietic_stem1.54920819
40MP0003763_abnormal_thymus_physiology1.53742769
41MP0003011_delayed_dark_adaptation1.48328655
42MP0004142_abnormal_muscle_tone1.46561005
43MP0003123_paternal_imprinting1.45699675
44MP0000465_gastrointestinal_hemorrhage1.42834330
45MP0002398_abnormal_bone_marrow1.40801650
46MP0003121_genomic_imprinting1.40409152
47MP0005423_abnormal_somatic_nervous1.38605272
48MP0002095_abnormal_skin_pigmentation1.34324599
49MP0001293_anophthalmia1.33455401
50MP0003786_premature_aging1.32640738
51MP0002282_abnormal_trachea_morphology1.32410704
52MP0001730_embryonic_growth_arrest1.30954834
53MP0005248_abnormal_Harderian_gland1.29958458
54MP0000049_abnormal_middle_ear1.29938156
55MP0000703_abnormal_thymus_morphology1.28985560
56MP0001835_abnormal_antigen_presentation1.25524937
57MP0000685_abnormal_immune_system1.24024492
58MP0009053_abnormal_anal_canal1.23230433
59MP0009333_abnormal_splenocyte_physiolog1.23215481
60MP0005174_abnormal_tail_pigmentation1.21512256
61MP0008877_abnormal_DNA_methylation1.20823985
62MP0001485_abnormal_pinna_reflex1.19249800
63MP0000955_abnormal_spinal_cord1.18879033
64MP0002928_abnormal_bile_duct1.18682873
65MP0005377_hearing/vestibular/ear_phenot1.18544956
66MP0003878_abnormal_ear_physiology1.18544956
67MP0002019_abnormal_tumor_incidence1.17169587
68MP0002009_preneoplasia1.15860540
69MP0004742_abnormal_vestibular_system1.14016282
70MP0000313_abnormal_cell_death1.12387674
71MP0002166_altered_tumor_susceptibility1.12303644
72MP0002085_abnormal_embryonic_tissue1.12244080
73MP0002722_abnormal_immune_system1.11767542
74MP0001697_abnormal_embryo_size1.11235987
75MP0001800_abnormal_humoral_immune1.08190601
76MP0001545_abnormal_hematopoietic_system1.06546358
77MP0005397_hematopoietic_system_phenotyp1.06546358
78MP0005671_abnormal_response_to1.06331847
79MP0002429_abnormal_blood_cell1.06283257
80MP0003938_abnormal_ear_development1.06225845
81MP0000689_abnormal_spleen_morphology1.05099247
82MP0002752_abnormal_somatic_nervous1.04236041
83MP0003937_abnormal_limbs/digits/tail_de1.04091728
84MP0000716_abnormal_immune_system1.03016383
85MP0002132_abnormal_respiratory_system1.02777330
86MP0006072_abnormal_retinal_apoptosis1.02740588
87MP0003861_abnormal_nervous_system1.02580950
88MP0001984_abnormal_olfaction1.01911195
89MP0002080_prenatal_lethality1.01522602
90MP0002084_abnormal_developmental_patter1.01204188
91MP0002638_abnormal_pupillary_reflex1.01136703
92MP0003221_abnormal_cardiomyocyte_apopto1.00796558
93MP0002751_abnormal_autonomic_nervous1.00017911
94MP0002420_abnormal_adaptive_immunity0.99520698
95MP0002452_abnormal_antigen_presenting0.98286653
96MP0001286_abnormal_eye_development0.97666090
97MP0001819_abnormal_immune_cell0.97584747
98MP0004811_abnormal_neuron_physiology0.97212895
99MP0006035_abnormal_mitochondrial_morpho0.97156478
100MP0002092_abnormal_eye_morphology0.96264388
101MP0002098_abnormal_vibrissa_morphology0.95920283
102MP0009278_abnormal_bone_marrow0.94877969
103MP0002163_abnormal_gland_morphology0.94199058
104MP0008995_early_reproductive_senescence0.93956848
105MP0002932_abnormal_joint_morphology0.93228746
106MP0003303_peritoneal_inflammation0.91776951
107MP0003890_abnormal_embryonic-extraembry0.89902815
108MP0002210_abnormal_sex_determination0.89090147
109MP0000026_abnormal_inner_ear0.88301564
110MP0002152_abnormal_brain_morphology0.87297419
111MP0002277_abnormal_respiratory_mucosa0.87091474
112MP0002006_tumorigenesis0.86743567
113MP0004197_abnormal_fetal_growth/weight/0.85419403
114MP0001324_abnormal_eye_pigmentation0.84282255
115MP0001672_abnormal_embryogenesis/_devel0.84103217
116MP0005380_embryogenesis_phenotype0.84103217
117MP0001879_abnormal_lymphatic_vessel0.83821196
118MP0005195_abnormal_posterior_eye0.83218849
119MP0005253_abnormal_eye_physiology0.81951345
120MP0002882_abnormal_neuron_morphology0.81831232
121MP0002735_abnormal_chemical_nociception0.81350837
122MP0002557_abnormal_social/conspecific_i0.80174741
123MP0010352_gastrointestinal_tract_polyps0.80124799
124MP0002723_abnormal_immune_serum0.78763762
125MP0005645_abnormal_hypothalamus_physiol0.77735626
126MP0003942_abnormal_urinary_system0.77317301
127MP0003866_abnormal_defecation0.77087063
128MP0003436_decreased_susceptibility_to0.76549067
129MP0002184_abnormal_innervation0.76396634
130MP0002067_abnormal_sensory_capabilities0.76353150
131MP0003119_abnormal_digestive_system0.76303723
132MP0009785_altered_susceptibility_to0.76279440
133MP0001905_abnormal_dopamine_level0.76260912
134MP0005075_abnormal_melanosome_morpholog0.76060094
135MP0005000_abnormal_immune_tolerance0.76034072
136MP0002405_respiratory_system_inflammati0.75999690
137MP0002233_abnormal_nose_morphology0.75146495
138MP0001145_abnormal_male_reproductive0.74938437
139MP0002697_abnormal_eye_size0.74578475
140MP0005220_abnormal_exocrine_pancreas0.74230533
141MP0005391_vision/eye_phenotype0.74207465
142MP0000631_abnormal_neuroendocrine_gland0.73509129
143MP0005025_abnormal_response_to0.72630210
144MP0009765_abnormal_xenobiotic_induced0.71946034
145MP0003984_embryonic_growth_retardation0.71925825
146MP0002088_abnormal_embryonic_growth/wei0.71769537
147MP0002177_abnormal_outer_ear0.71689083
148MP0002234_abnormal_pharynx_morphology0.70994549
149MP0005187_abnormal_penis_morphology0.70685925
150MP0001346_abnormal_lacrimal_gland0.70531254
151MP0009764_decreased_sensitivity_to0.69944678
152MP0001986_abnormal_taste_sensitivity0.69835421
153MP0001663_abnormal_digestive_system0.69563118
154MP0001486_abnormal_startle_reflex0.69435355
155MP0000383_abnormal_hair_follicle0.69284846
156MP0002736_abnormal_nociception_after0.69235083
157MP0001970_abnormal_pain_threshold0.68865668
158MP0002419_abnormal_innate_immunity0.68765723
159MP0002733_abnormal_thermal_nociception0.67076554
160MP0003635_abnormal_synaptic_transmissio0.65306194
161MP0002063_abnormal_learning/memory/cond0.64652522
162MP0001968_abnormal_touch/_nociception0.63871729

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.95838068
2Reticulocytopenia (HP:0001896)5.82039202
3Abnormal number of erythroid precursors (HP:0012131)5.51550825
4Pallor (HP:0000980)3.92909221
5Macrocytic anemia (HP:0001972)3.80288617
6Colon cancer (HP:0003003)3.28548685
7Septo-optic dysplasia (HP:0100842)3.15457621
8Aplastic anemia (HP:0001915)3.04948777
9Hypochromic microcytic anemia (HP:0004840)2.93355616
10Abnormal respiratory epithelium morphology (HP:0012253)2.92221811
11Abnormal respiratory motile cilium morphology (HP:0005938)2.92221811
12Birth length less than 3rd percentile (HP:0003561)2.86158198
13Abnormal respiratory motile cilium physiology (HP:0012261)2.84225153
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.83041443
15Patellar aplasia (HP:0006443)2.82838273
16Abnormal ciliary motility (HP:0012262)2.80667290
1711 pairs of ribs (HP:0000878)2.77590860
18Acute necrotizing encephalopathy (HP:0006965)2.77169265
19Cortical dysplasia (HP:0002539)2.75354435
20Polyphagia (HP:0002591)2.73026653
21Aplasia/Hypoplasia of the sacrum (HP:0008517)2.72800687
22Aplasia/Hypoplasia of the patella (HP:0006498)2.70539098
23True hermaphroditism (HP:0010459)2.69153455
24Pancreatic fibrosis (HP:0100732)2.64205496
25Recurrent bacterial skin infections (HP:0005406)2.63025338
26Absent/shortened dynein arms (HP:0200106)2.57673336
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.57673336
28IgM deficiency (HP:0002850)2.56002220
29Increased hepatocellular lipid droplets (HP:0006565)2.54863932
30Eczematoid dermatitis (HP:0000976)2.53891166
31Abnormality of the heme biosynthetic pathway (HP:0010472)2.53191333
32Abnormality of the labia minora (HP:0012880)2.52610401
33Oral leukoplakia (HP:0002745)2.49287881
34Abnormal mitochondria in muscle tissue (HP:0008316)2.47449855
35Recurrent abscess formation (HP:0002722)2.47444969
36Gait imbalance (HP:0002141)2.46694669
37Thrombocytosis (HP:0001894)2.44287719
38Medial flaring of the eyebrow (HP:0010747)2.42335772
39Myokymia (HP:0002411)2.42118179
40Pancreatic cysts (HP:0001737)2.41032437
413-Methylglutaconic aciduria (HP:0003535)2.40540370
42Mitochondrial inheritance (HP:0001427)2.38358972
43Stomatitis (HP:0010280)2.38237570
44Abnormal number of incisors (HP:0011064)2.35799731
45Microretrognathia (HP:0000308)2.32853063
46Limb dystonia (HP:0002451)2.32662182
47Congenital primary aphakia (HP:0007707)2.31906906
48Acute encephalopathy (HP:0006846)2.31450343
49Growth hormone deficiency (HP:0000824)2.31127491
50Encephalitis (HP:0002383)2.29003528
51Lipid accumulation in hepatocytes (HP:0006561)2.27427823
52Depressed nasal ridge (HP:0000457)2.26234176
53Atresia of the external auditory canal (HP:0000413)2.24474373
54Molar tooth sign on MRI (HP:0002419)2.24015876
55Abnormality of midbrain morphology (HP:0002418)2.24015876
56Agitation (HP:0000713)2.21124032
57Nephrogenic diabetes insipidus (HP:0009806)2.19928228
58Progressive macrocephaly (HP:0004481)2.17981169
59Abnormality of B cell number (HP:0010975)2.17924319
60B lymphocytopenia (HP:0010976)2.17924319
61Optic nerve coloboma (HP:0000588)2.16947411
62Short 4th metacarpal (HP:0010044)2.13538363
63Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.13538363
64Anophthalmia (HP:0000528)2.12098481
65Pendular nystagmus (HP:0012043)2.11982488
66Abnormal lung lobation (HP:0002101)2.11192750
67Triphalangeal thumb (HP:0001199)2.11108254
68Breast hypoplasia (HP:0003187)2.10181436
69Myositis (HP:0100614)2.09601079
70Nephronophthisis (HP:0000090)2.08600605
71Short middle phalanx of the 5th finger (HP:0004220)2.07376445
72Respiratory difficulties (HP:0002880)2.07297671
73Neoplasm of the pancreas (HP:0002894)2.05413161
74Retrobulbar optic neuritis (HP:0100654)2.04722196
75Optic neuritis (HP:0100653)2.04722196
76Recurrent bronchitis (HP:0002837)2.04406904
77Rhinitis (HP:0012384)2.04091248
78Volvulus (HP:0002580)2.03952526
79Meckel diverticulum (HP:0002245)2.03684453
80Agammaglobulinemia (HP:0004432)2.03429165
81Abnormal hair whorl (HP:0010721)2.03256812
82Obstructive lung disease (HP:0006536)2.03088840
83Chronic obstructive pulmonary disease (HP:0006510)2.03088840
84Renal Fanconi syndrome (HP:0001994)2.02564929
85Abnormality of the preputium (HP:0100587)2.02503985
86Maternal diabetes (HP:0009800)2.01669057
87Thick lower lip vermilion (HP:0000179)2.01615075
88Vaginal atresia (HP:0000148)2.00535006
89Chronic bronchitis (HP:0004469)1.99989333
90Abnormality of the ileum (HP:0001549)1.99600902
91Recurrent gram-negative bacterial infections (HP:0005420)1.99014645
92Congenital, generalized hypertrichosis (HP:0004540)1.98656925
93Orchitis (HP:0100796)1.98294542
94Medulloblastoma (HP:0002885)1.98020199
95Proximal placement of thumb (HP:0009623)1.97812869
96Panhypogammaglobulinemia (HP:0003139)1.97799589
97Absent septum pellucidum (HP:0001331)1.97607102
98Rib fusion (HP:0000902)1.97069261
99Hyperglycinemia (HP:0002154)1.95856079
100Aplasia/Hypoplasia of the uvula (HP:0010293)1.95386361
101Selective tooth agenesis (HP:0001592)1.94509088
102Genital tract atresia (HP:0001827)1.94473732
103Lymphoma (HP:0002665)1.94123894
104Absent thumb (HP:0009777)1.93962118
105Abnormal hemoglobin (HP:0011902)1.93446299
106Myelodysplasia (HP:0002863)1.92188999
107Thyroiditis (HP:0100646)1.88126167
108Optic nerve hypoplasia (HP:0000609)1.87332068
109Specific learning disability (HP:0001328)1.87249610
110Cleft eyelid (HP:0000625)1.86291544
111Acute lymphatic leukemia (HP:0006721)1.85531664
112IgG deficiency (HP:0004315)1.85239548
113Hypogonadotrophic hypogonadism (HP:0000044)1.84568887
114Small intestinal stenosis (HP:0012848)1.83504085
115Duodenal stenosis (HP:0100867)1.83504085
116Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83380130
117Increased CSF lactate (HP:0002490)1.82800542
118Severe visual impairment (HP:0001141)1.82724116
119Abnormality of renal resorption (HP:0011038)1.81407169
120Sclerocornea (HP:0000647)1.81021791
121Chronic otitis media (HP:0000389)1.81006389
122Abnormality of the intervertebral disk (HP:0005108)1.80434686
123Increased nuchal translucency (HP:0010880)1.80300483
124Stenosis of the external auditory canal (HP:0000402)1.79950571
125Abnormality of the anterior horn cell (HP:0006802)1.79777694
126Degeneration of anterior horn cells (HP:0002398)1.79777694
127Rough bone trabeculation (HP:0100670)1.79582683
128Anencephaly (HP:0002323)1.79471209
129Lissencephaly (HP:0001339)1.77605171
130Abnormality of chromosome stability (HP:0003220)1.77343880
131Hypochromic anemia (HP:0001931)1.76589014
132Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74497425
133Cellulitis (HP:0100658)1.73519797
134Horseshoe kidney (HP:0000085)1.73418813
135Abnormality of cells of the lymphoid lineage (HP:0012140)1.72954338
136Multiple enchondromatosis (HP:0005701)1.72490737
137Glossoptosis (HP:0000162)1.72172380
138Abnormal rod and cone electroretinograms (HP:0008323)1.71987330
139Bilateral microphthalmos (HP:0007633)1.71478242
140Degeneration of the lateral corticospinal tracts (HP:0002314)1.71132019
141Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.71132019
142Petechiae (HP:0000967)1.70839117
143Hepatoblastoma (HP:0002884)1.70549629
144Elevated erythrocyte sedimentation rate (HP:0003565)1.70372619
145Tracheoesophageal fistula (HP:0002575)1.69708358
146Poikiloderma (HP:0001029)1.69609291
147Aplasia/Hypoplasia of the thymus (HP:0010515)1.69269752
148Poor coordination (HP:0002370)1.69081369
149Optic disc pallor (HP:0000543)1.67977052
150Oligodactyly (hands) (HP:0001180)1.67951527
151Facial hemangioma (HP:0000329)1.67856944
152Abnormality of the septum pellucidum (HP:0007375)1.67646355
153Amyotrophic lateral sclerosis (HP:0007354)1.66910821
154Microcytic anemia (HP:0001935)1.66604211
155Chromsome breakage (HP:0040012)1.66591525
156Lymphopenia (HP:0001888)1.66218782
157Hypoplasia of the radius (HP:0002984)1.66070785
158Overlapping toe (HP:0001845)1.66005484
159Deviation of the thumb (HP:0009603)1.65414141
160Premature graying of hair (HP:0002216)1.64715969
161Anosmia (HP:0000458)1.64325822
162Abnormality of reticulocytes (HP:0004312)1.63898421
163Hemivertebrae (HP:0002937)1.63221346
164Abolished electroretinogram (ERG) (HP:0000550)1.62904500
165Increased IgM level (HP:0003496)1.62732952
166Basal cell carcinoma (HP:0002671)1.61779502
167Cellular immunodeficiency (HP:0005374)1.61543621
168Supernumerary spleens (HP:0009799)1.61318603
169Exertional dyspnea (HP:0002875)1.61226353
170Concave nail (HP:0001598)1.60934108
171Severe combined immunodeficiency (HP:0004430)1.60329243
172Aplasia/Hypoplasia of the sternum (HP:0006714)1.60159712
173Trismus (HP:0000211)1.59537761
174Carpal bone hypoplasia (HP:0001498)1.59289521
175Recurrent viral infections (HP:0004429)1.56708646
176Bone marrow hypocellularity (HP:0005528)1.55445385
177Muscle fiber atrophy (HP:0100295)1.55253790
178Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.54381454
179Decreased activity of mitochondrial respiratory chain (HP:0008972)1.54381454
180Abnormality of the duodenum (HP:0002246)1.53736676
181Chromosomal breakage induced by crosslinking agents (HP:0003221)1.53075252
182Chronic sinusitis (HP:0011109)1.50560906
183Meningitis (HP:0001287)1.50337646

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.55080181
2WEE13.28460480
3CDC73.09994533
4STK162.89763097
5SRPK12.75688083
6ACVR1B2.61423445
7EIF2AK12.51211442
8VRK12.41635160
9TLK12.40285083
10MAP2K72.39218113
11NME22.38682221
12CASK2.33701267
13MAP3K102.30288333
14RIPK42.22006817
15MKNK12.21644034
16NEK22.21368760
17MAP3K42.21187062
18WNK32.19023484
19TGFBR12.14162304
20TESK22.10768905
21PASK2.00765403
22MARK11.97090959
23MAP2K41.87913569
24VRK21.80138306
25RPS6KA41.78372848
26EIF2AK31.55920303
27RPS6KB21.52593653
28BRSK21.51507827
29EEF2K1.47843195
30CSK1.45123475
31CDK71.44486763
32* AURKB1.41130275
33ERBB31.39796777
34TAOK11.38798700
35LRRK21.36646953
36* DYRK31.36392849
37FES1.33422889
38FGR1.33183100
39MKNK21.32775626
40TRIM281.32014665
41ATR1.29583627
42MINK11.28180197
43PLK11.27858197
44MATK1.27677385
45MAP3K111.27436304
46BTK1.25939187
47MAP4K11.25029833
48EPHA31.21101984
49CSNK1G21.19131314
50TNK21.17985293
51TEC1.16134071
52BLK1.15244758
53CCNB11.12654953
54LIMK11.12262569
55STK41.11432812
56PIM21.11203070
57MAP4K21.11199135
58PNCK1.10397091
59TAF11.09363639
60SIK31.08137363
61CDK81.07806119
62RPS6KA51.07399123
63KIT1.07250976
64CDK41.07186474
65BCKDK1.07042264
66BRD41.05587891
67UHMK11.05465368
68MAP3K61.05341012
69CLK11.04454587
70PLK41.02445154
71CSF1R1.02329338
72KSR11.02263329
73SIK21.01384901
74PAK41.00804160
75AURKA0.97497831
76EPHB10.97273706
77BMPR1B0.96881592
78CHEK20.95534133
79FLT30.94792088
80SCYL20.94750137
81YES10.93568451
82CSNK1G30.91920202
83KDR0.91502166
84NUAK10.91117020
85NTRK20.91017718
86BRSK10.90728986
87ILK0.89713665
88IRAK10.88974673
89STK100.87183240
90CDK90.86057201
91STK110.85647554
92EPHB20.85557502
93TESK10.85456245
94MST40.85293317
95ZAK0.84629031
96MAPK130.82315991
97MAP3K80.81282373
98MAPKAPK30.80098533
99IRAK40.79606460
100PIM10.78038669
101NME10.78008924
102BCR0.76001305
103PTK60.75725552
104HCK0.75131819
105EIF2AK20.74743739
106* DYRK20.73661660
107MARK30.73537393
108NLK0.73431172
109PINK10.72448373
110CSNK1A1L0.72175588
111CHEK10.71575455
112ADRBK20.71292047
113CSNK1G10.70396537
114MARK20.69863319
115PLK30.69430356
116TTK0.67740419
117CDK60.67698719
118LYN0.66552004
119SGK4940.66212676
120SGK2230.66212676
121SYK0.66189055
122JAK20.66064944
123HIPK20.65835859
124CDK190.65804696
125TAOK30.65318831
126IRAK20.64679381
127CSNK2A10.64101884
128GRK60.63802280
129MAP3K50.63190772
130PRKCG0.62668852
131MAP2K30.59992870
132CDK140.59113038
133PRKCZ0.58802959
134PBK0.58497579
135PAK30.56526806
136CSNK2A20.55388945
137MELK0.53713521
138TXK0.53250980
139ATM0.51700773
140CDK30.51692122
141ERBB20.51158357
142LCK0.48270884
143CDK20.46451342
144PAK10.46391799
145ZAP700.45500236
146ITK0.44768803
147OXSR10.43644756
148SGK20.42958090
149MAPK40.42065150
150TYK20.41621215
151STK240.41303425
152CDK10.40405733
153TGFBR20.39060637
154MAPKAPK20.38173982
155AKT20.36245142
156TNIK0.35367738
157TBK10.35366404
158MAP2K20.34824698
159MAPK150.34595948

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.81512427
2DNA replication_Homo sapiens_hsa030304.39806289
3Spliceosome_Homo sapiens_hsa030403.46299130
4Mismatch repair_Homo sapiens_hsa034303.45713625
5Base excision repair_Homo sapiens_hsa034102.80964800
6Proteasome_Homo sapiens_hsa030502.80667834
7RNA polymerase_Homo sapiens_hsa030202.72251385
8Homologous recombination_Homo sapiens_hsa034402.54938334
9Nucleotide excision repair_Homo sapiens_hsa034202.52665655
10Cell cycle_Homo sapiens_hsa041102.52101969
11Pyrimidine metabolism_Homo sapiens_hsa002402.20250693
12RNA transport_Homo sapiens_hsa030132.18565609
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.94508490
14Non-homologous end-joining_Homo sapiens_hsa034501.92980951
15* Systemic lupus erythematosus_Homo sapiens_hsa053221.80372553
16Cardiac muscle contraction_Homo sapiens_hsa042601.80118277
17Fanconi anemia pathway_Homo sapiens_hsa034601.80036578
18Protein export_Homo sapiens_hsa030601.75348544
19Basal transcription factors_Homo sapiens_hsa030221.66734744
20Primary immunodeficiency_Homo sapiens_hsa053401.53531858
21RNA degradation_Homo sapiens_hsa030181.52450470
22p53 signaling pathway_Homo sapiens_hsa041151.52260973
23mRNA surveillance pathway_Homo sapiens_hsa030151.49589036
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.39938377
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39716126
26Regulation of autophagy_Homo sapiens_hsa041401.37886629
27Nicotine addiction_Homo sapiens_hsa050331.36498011
28Collecting duct acid secretion_Homo sapiens_hsa049661.36037175
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33921278
30Epstein-Barr virus infection_Homo sapiens_hsa051691.26075298
31Herpes simplex infection_Homo sapiens_hsa051681.22263936
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20257442
33Phagosome_Homo sapiens_hsa041451.13607491
34Chemokine signaling pathway_Homo sapiens_hsa040621.13194602
35Viral carcinogenesis_Homo sapiens_hsa052031.11868423
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10246360
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09059339
38* Alcoholism_Homo sapiens_hsa050341.08981547
39Purine metabolism_Homo sapiens_hsa002301.07316471
40Axon guidance_Homo sapiens_hsa043601.06129985
41* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04030781
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02857796
43Antigen processing and presentation_Homo sapiens_hsa046121.02087076
44Phototransduction_Homo sapiens_hsa047441.01721445
45Steroid biosynthesis_Homo sapiens_hsa001000.96301459
46One carbon pool by folate_Homo sapiens_hsa006700.94801024
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93467512
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93211899
49Staphylococcus aureus infection_Homo sapiens_hsa051500.92741755
50HTLV-I infection_Homo sapiens_hsa051660.87799443
51Parkinsons disease_Homo sapiens_hsa050120.86079556
52Hematopoietic cell lineage_Homo sapiens_hsa046400.85925631
53Morphine addiction_Homo sapiens_hsa050320.85592832
54Small cell lung cancer_Homo sapiens_hsa052220.82748918
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82340852
56Colorectal cancer_Homo sapiens_hsa052100.80498610
57B cell receptor signaling pathway_Homo sapiens_hsa046620.80011260
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78795999
59Huntingtons disease_Homo sapiens_hsa050160.78727515
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77525513
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77247880
62Chronic myeloid leukemia_Homo sapiens_hsa052200.75509523
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74081770
64MicroRNAs in cancer_Homo sapiens_hsa052060.73517506
65GABAergic synapse_Homo sapiens_hsa047270.73426762
66Serotonergic synapse_Homo sapiens_hsa047260.73087699
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72078033
68Basal cell carcinoma_Homo sapiens_hsa052170.71466432
69Tuberculosis_Homo sapiens_hsa051520.70835435
70N-Glycan biosynthesis_Homo sapiens_hsa005100.70758098
71Notch signaling pathway_Homo sapiens_hsa043300.69815602
72Shigellosis_Homo sapiens_hsa051310.69052436
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68183907
74Cocaine addiction_Homo sapiens_hsa050300.67860969
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67697142
76Dopaminergic synapse_Homo sapiens_hsa047280.67563933
77Legionellosis_Homo sapiens_hsa051340.67446485
78Hepatitis B_Homo sapiens_hsa051610.67162387
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65731981
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.65296007
81Measles_Homo sapiens_hsa051620.64039368
82Oocyte meiosis_Homo sapiens_hsa041140.63606971
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.63404042
84Viral myocarditis_Homo sapiens_hsa054160.62151839
85Thyroid cancer_Homo sapiens_hsa052160.61552219
86Apoptosis_Homo sapiens_hsa042100.61436019
87Folate biosynthesis_Homo sapiens_hsa007900.61401372
88Oxidative phosphorylation_Homo sapiens_hsa001900.60392329
89Sulfur relay system_Homo sapiens_hsa041220.59747668
90Gap junction_Homo sapiens_hsa045400.57584198
91Olfactory transduction_Homo sapiens_hsa047400.57529442
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56975686
93Salmonella infection_Homo sapiens_hsa051320.56898247
94Leishmaniasis_Homo sapiens_hsa051400.56384352
95Arachidonic acid metabolism_Homo sapiens_hsa005900.56079527
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55441344
97Linoleic acid metabolism_Homo sapiens_hsa005910.53618565
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51696157
99TGF-beta signaling pathway_Homo sapiens_hsa043500.51382299
100Pathways in cancer_Homo sapiens_hsa052000.50902528
101Malaria_Homo sapiens_hsa051440.50783156
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50627186
103Pancreatic cancer_Homo sapiens_hsa052120.49721715
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49667321
105Hedgehog signaling pathway_Homo sapiens_hsa043400.48601989
106Asthma_Homo sapiens_hsa053100.47878383
107Cholinergic synapse_Homo sapiens_hsa047250.47441190
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.47340414
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47293368
110Acute myeloid leukemia_Homo sapiens_hsa052210.46486084
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46036541
112Non-small cell lung cancer_Homo sapiens_hsa052230.45777714
113T cell receptor signaling pathway_Homo sapiens_hsa046600.42449842
114Graft-versus-host disease_Homo sapiens_hsa053320.42206111
115Taste transduction_Homo sapiens_hsa047420.42119550
116Hippo signaling pathway_Homo sapiens_hsa043900.41741886
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41733728
118Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41037938
119Peroxisome_Homo sapiens_hsa041460.39238419
120Bladder cancer_Homo sapiens_hsa052190.38880631
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.38810909
122Autoimmune thyroid disease_Homo sapiens_hsa053200.38563291
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38444555
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38046941
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.36521956
126Alzheimers disease_Homo sapiens_hsa050100.36478583
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36255364
128Long-term depression_Homo sapiens_hsa047300.36214275
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35654144
130Allograft rejection_Homo sapiens_hsa053300.35542967
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35187441
132Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35099748
133Ether lipid metabolism_Homo sapiens_hsa005650.33159137
134Wnt signaling pathway_Homo sapiens_hsa043100.32920565
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32157095
136Prostate cancer_Homo sapiens_hsa052150.31566464
137Glutamatergic synapse_Homo sapiens_hsa047240.30489464
138Influenza A_Homo sapiens_hsa051640.30404501
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30168022
140Metabolic pathways_Homo sapiens_hsa011000.29074552
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28760874
142Toxoplasmosis_Homo sapiens_hsa051450.28447797
143Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27926909
144Glutathione metabolism_Homo sapiens_hsa004800.26480861
145Pertussis_Homo sapiens_hsa051330.26317861
146Osteoclast differentiation_Homo sapiens_hsa043800.22096319

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