ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.26139831
2	DNA deamination (GO:0045006)	5.88998461
3	cytidine deamination (GO:0009972)	5.56084164
4	cytidine metabolic process (GO:0046087)	5.56084164
5	cytidine catabolic process (GO:0006216)	5.56084164
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.33107869
7	pyrimidine ribonucleoside catabolic process (GO:0046133)	5.00308234
8	ATP synthesis coupled proton transport (GO:0015986)	4.98752010
9	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.98752010
10	protein neddylation (GO:0045116)	4.93036902
11	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.55157701
12	pyrimidine nucleobase catabolic process (GO:0006208)	4.51307568
13	protein polyglutamylation (GO:0018095)	4.08320781
14	regulation of cilium movement (GO:0003352)	4.03179148
15	ribosomal small subunit assembly (GO:0000028)	3.93761773
16	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.86166856
17	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.77449175
18	NADH dehydrogenase complex assembly (GO:0010257)	3.77449175
19	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.77449175
20	sequestering of actin monomers (GO:0042989)	3.72860080
21	nucleobase catabolic process (GO:0046113)	3.61788653
22	electron transport chain (GO:0022900)	3.60145983
23	respiratory electron transport chain (GO:0022904)	3.58548755
24	ubiquinone biosynthetic process (GO:0006744)	3.53564147
25	protein complex biogenesis (GO:0070271)	3.50745706
26	ubiquinone metabolic process (GO:0006743)	3.38985005
27	negative regulation of telomere maintenance (GO:0032205)	3.29962569
28	chaperone-mediated protein transport (GO:0072321)	3.28080165
29	synaptic transmission, cholinergic (GO:0007271)	3.24994078
30	water-soluble vitamin biosynthetic process (GO:0042364)	3.19727787
31	axoneme assembly (GO:0035082)	3.16137024
32	hydrogen ion transmembrane transport (GO:1902600)	3.14350420
33	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.13077506
34	pyrimidine-containing compound catabolic process (GO:0072529)	3.07722382
35	nonmotile primary cilium assembly (GO:0035058)	3.06614518
36	mitochondrial respiratory chain complex assembly (GO:0033108)	3.04813855
37	kynurenine metabolic process (GO:0070189)	2.97262493
38	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.97102327
39	maturation of SSU-rRNA (GO:0030490)	2.95624322
40	fucose catabolic process (GO:0019317)	2.95509281
41	L-fucose metabolic process (GO:0042354)	2.95509281
42	L-fucose catabolic process (GO:0042355)	2.95509281
43	positive regulation of mitochondrial fission (GO:0090141)	2.92522456
44	indolalkylamine metabolic process (GO:0006586)	2.90967618
45	viral transcription (GO:0019083)	2.90956797
46	establishment of mitochondrion localization (GO:0051654)	2.90843448
47	proton transport (GO:0015992)	2.90177408
48	regulation of microtubule-based movement (GO:0060632)	2.90118896
49	translational termination (GO:0006415)	2.88400956
50	piRNA metabolic process (GO:0034587)	2.86612159
51	hydrogen transport (GO:0006818)	2.85467551
52	platelet dense granule organization (GO:0060155)	2.85200434
53	protein-cofactor linkage (GO:0018065)	2.83725721
54	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.82607482
55	cell proliferation in forebrain (GO:0021846)	2.82351446
56	quinone biosynthetic process (GO:1901663)	2.80374882
57	negative regulation of appetite (GO:0032099)	2.79370229
58	negative regulation of response to food (GO:0032096)	2.79370229
59	amine catabolic process (GO:0009310)	2.78745634
60	cellular biogenic amine catabolic process (GO:0042402)	2.78745634
61	transmission of nerve impulse (GO:0019226)	2.74033226
62	DNA demethylation (GO:0080111)	2.73547558
63	ATP biosynthetic process (GO:0006754)	2.72616608
64	epithelial cilium movement (GO:0003351)	2.72380459
65	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.70698408
66	parturition (GO:0007567)	2.69597113
67	termination of RNA polymerase III transcription (GO:0006386)	2.66334413
68	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.66334413
69	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.65158117
70	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.65016597
71	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.65016597
72	indole-containing compound catabolic process (GO:0042436)	2.64211142
73	indolalkylamine catabolic process (GO:0046218)	2.64211142
74	tryptophan catabolic process (GO:0006569)	2.64211142
75	response to pheromone (GO:0019236)	2.61616261
76	translational elongation (GO:0006414)	2.60696881
77	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.60506812
78	positive regulation of prostaglandin secretion (GO:0032308)	2.60460269
79	positive regulation of fatty acid transport (GO:2000193)	2.59822816
80	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.59355394
81	organelle disassembly (GO:1903008)	2.57659247
82	head development (GO:0060322)	2.57165764
83	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.55997975
84	protein localization to cilium (GO:0061512)	2.55342996
85	seminiferous tubule development (GO:0072520)	2.54507945
86	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.52117016
87	pyrimidine nucleotide catabolic process (GO:0006244)	2.51020525
88	cotranslational protein targeting to membrane (GO:0006613)	2.50412785
89	neurofilament cytoskeleton organization (GO:0060052)	2.50330218
90	endoderm formation (GO:0001706)	2.48162970
91	protein targeting to ER (GO:0045047)	2.47920397
92	ribonucleoprotein complex disassembly (GO:0032988)	2.45042199
93	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.44927458
94	pyrimidine nucleoside catabolic process (GO:0046135)	2.44464738
95	preassembly of GPI anchor in ER membrane (GO:0016254)	2.43674121
96	tryptophan metabolic process (GO:0006568)	2.43270281
97	GTP biosynthetic process (GO:0006183)	2.41539563
98	positive regulation of defense response to virus by host (GO:0002230)	2.41479592
99	respiratory chain complex IV assembly (GO:0008535)	2.40240626
100	mannosylation (GO:0097502)	2.38556034

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.60272139
2	VDR_22108803_ChIP-Seq_LS180_Human	3.35866238
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.29426629
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.22639147
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.04108230
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.63642083
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.52146895
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.51732012
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.26775690
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.21994733
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.05258291
12	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.03043135
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.88993671
14	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.86391529
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.86001376
16	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.85996362
17	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.85733649
18	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.75394990
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.72920925
20	IRF1_19129219_ChIP-ChIP_H3396_Human	1.71919816
21	REST_21632747_ChIP-Seq_MESCs_Mouse	1.71558951
22	RNF2_27304074_Chip-Seq_NSC_Mouse	1.70399920
23	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.68182499
24	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.67516151
25	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.66972069
26	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.63857814
27	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.62907642
28	TAF15_26573619_Chip-Seq_HEK293_Human	1.56802089
29	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.55108485
30	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.54357088
31	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.54179611
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.53341967
33	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.52769613
34	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.49757384
35	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.48557221
36	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.44458730
37	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.43803285
38	VDR_23849224_ChIP-Seq_CD4+_Human	1.38540668
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.38424766
40	GBX2_23144817_ChIP-Seq_PC3_Human	1.35932796
41	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.35390771
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32414791
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.31066213
44	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.29614639
45	ERA_21632823_ChIP-Seq_H3396_Human	1.28345967
46	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28270484
47	NCOR_22424771_ChIP-Seq_293T_Human	1.25903806
48	TAF2_19829295_ChIP-Seq_ESCs_Human	1.25831668
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.25534112
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.25534112
51	MYC_19829295_ChIP-Seq_ESCs_Human	1.24244698
52	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.23450175
53	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.21426558
54	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.20905543
55	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.20066216
56	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19798588
57	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.18658542
58	P300_19829295_ChIP-Seq_ESCs_Human	1.18554222
59	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.18198886
60	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.18198886
61	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.17504587
62	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.15281971
63	NANOG_20526341_ChIP-Seq_ESCs_Human	1.14436568
64	FUS_26573619_Chip-Seq_HEK293_Human	1.13056645
65	FOXP3_21729870_ChIP-Seq_TREG_Human	1.12707151
66	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11850807
67	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.11761400
68	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.10865619
69	EWS_26573619_Chip-Seq_HEK293_Human	1.07053558
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05168755
71	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05168755
72	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.04446616
73	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.02235784
74	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.02216081
75	ER_23166858_ChIP-Seq_MCF-7_Human	0.99480491
76	P53_21459846_ChIP-Seq_SAOS-2_Human	0.99175545
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97303742
78	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.97158458
79	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.96528217
80	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.96201256
81	AR_20517297_ChIP-Seq_VCAP_Human	0.96144763
82	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.95731889
83	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95344971
84	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.94889963
85	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.94029887
86	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.93256187
87	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93256187
88	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.92610211
89	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.92554817
90	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.92208747
91	BCL6_27268052_Chip-Seq_Bcells_Human	0.91851764
92	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.91516372
93	E2F1_20622854_ChIP-Seq_HELA_Human	0.91362638
94	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.91116348
95	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.90832913
96	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.90234695
97	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.89366027
98	HTT_18923047_ChIP-ChIP_STHdh_Human	0.88531655
99	ELK1_19687146_ChIP-ChIP_HELA_Human	0.88507214
100	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.88219735

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	3.36179192
2	MP0006292_abnormal_olfactory_placode	3.20529492
3	MP0009379_abnormal_foot_pigmentation	2.78278868
4	MP0003880_abnormal_central_pattern	2.70538462
5	MP0008877_abnormal_DNA_methylation	2.52582218
6	MP0008789_abnormal_olfactory_epithelium	2.44292379
7	MP0006276_abnormal_autonomic_nervous	2.43880449
8	MP0005646_abnormal_pituitary_gland	2.35400474
9	MP0004142_abnormal_muscle_tone	2.32284049
10	MP0004145_abnormal_muscle_electrophysio	2.27941885
11	MP0005394_taste/olfaction_phenotype	2.16639491
12	MP0005499_abnormal_olfactory_system	2.16639491
13	MP0003122_maternal_imprinting	2.15462216
14	MP0002102_abnormal_ear_morphology	2.12744536
15	MP0001968_abnormal_touch/_nociception	2.02564608
16	MP0002653_abnormal_ependyma_morphology	2.00203817
17	MP0001529_abnormal_vocalization	1.98745355
18	MP0005671_abnormal_response_to	1.98289375
19	MP0001984_abnormal_olfaction	1.92564078
20	MP0002876_abnormal_thyroid_physiology	1.86150022
21	MP0005551_abnormal_eye_electrophysiolog	1.82603976
22	MP0002272_abnormal_nervous_system	1.81746054
23	MP0003121_genomic_imprinting	1.81396680
24	MP0004742_abnormal_vestibular_system	1.77780056
25	MP0006072_abnormal_retinal_apoptosis	1.75996494
26	MP0009745_abnormal_behavioral_response	1.75546144
27	MP0009046_muscle_twitch	1.72341424
28	MP0008872_abnormal_physiological_respon	1.60926927
29	MP0005423_abnormal_somatic_nervous	1.60009278
30	MP0001970_abnormal_pain_threshold	1.58961020
31	MP0001905_abnormal_dopamine_level	1.58425991
32	MP0002736_abnormal_nociception_after	1.57487312
33	MP0001986_abnormal_taste_sensitivity	1.56763610
34	MP0001188_hyperpigmentation	1.55871605
35	MP0005645_abnormal_hypothalamus_physiol	1.52872356
36	MP0003635_abnormal_synaptic_transmissio	1.52341256
37	MP0002733_abnormal_thermal_nociception	1.50453101
38	MP0004885_abnormal_endolymph	1.49577165
39	MP0002572_abnormal_emotion/affect_behav	1.47574621
40	MP0002557_abnormal_social/conspecific_i	1.46933537
41	MP0002063_abnormal_learning/memory/cond	1.44481218
42	MP0000778_abnormal_nervous_system	1.43057779
43	MP0005084_abnormal_gallbladder_morpholo	1.42775394
44	MP0008875_abnormal_xenobiotic_pharmacok	1.39045308
45	MP0004859_abnormal_synaptic_plasticity	1.38451173
46	MP0002735_abnormal_chemical_nociception	1.37670503
47	MP0005253_abnormal_eye_physiology	1.35603539
48	MP0002837_dystrophic_cardiac_calcinosis	1.33715804
49	MP0008995_early_reproductive_senescence	1.33210091
50	MP0002064_seizures	1.28594230
51	MP0002184_abnormal_innervation	1.24212907
52	MP0001486_abnormal_startle_reflex	1.23983499
53	MP0001485_abnormal_pinna_reflex	1.21843737
54	MP0001919_abnormal_reproductive_system	1.20758569
55	MP0005389_reproductive_system_phenotype	1.18091025
56	MP0000049_abnormal_middle_ear	1.16592570
57	MP0000955_abnormal_spinal_cord	1.14572383
58	MP0002067_abnormal_sensory_capabilities	1.14023906
59	MP0001293_anophthalmia	1.13878813
60	MP0002163_abnormal_gland_morphology	1.12292041
61	MP0003011_delayed_dark_adaptation	1.08945080
62	MP0002752_abnormal_somatic_nervous	1.08149808
63	MP0000631_abnormal_neuroendocrine_gland	1.07997294
64	MP0002734_abnormal_mechanical_nocicepti	1.05603702
65	MP0000372_irregular_coat_pigmentation	1.03444003
66	MP0001440_abnormal_grooming_behavior	1.03033679
67	MP0002160_abnormal_reproductive_system	1.02694915
68	MP0002095_abnormal_skin_pigmentation	1.02655818
69	MP0005195_abnormal_posterior_eye	1.02647364
70	MP0004133_heterotaxia	1.02033803
71	MP0003646_muscle_fatigue	1.00706557
72	MP0003878_abnormal_ear_physiology	0.99844025
73	MP0005377_hearing/vestibular/ear_phenot	0.99844025
74	MP0003879_abnormal_hair_cell	0.98136335
75	MP0003567_abnormal_fetal_cardiomyocyte	0.96304201
76	MP0002638_abnormal_pupillary_reflex	0.94733776
77	MP0003123_paternal_imprinting	0.94628102
78	MP0002138_abnormal_hepatobiliary_system	0.94572769
79	MP0002882_abnormal_neuron_morphology	0.94241855
80	MP0000569_abnormal_digit_pigmentation	0.93706642
81	MP0002148_abnormal_hypersensitivity_rea	0.91216838
82	MP0005386_behavior/neurological_phenoty	0.90673427
83	MP0004924_abnormal_behavior	0.90673427
84	MP0000230_abnormal_systemic_arterial	0.90512525
85	MP0000026_abnormal_inner_ear	0.87831166
86	MP0002234_abnormal_pharynx_morphology	0.81816796
87	MP0004147_increased_porphyrin_level	0.79738772
88	MP0005410_abnormal_fertilization	0.77727026
89	MP0002909_abnormal_adrenal_gland	0.77175514
90	MP0008775_abnormal_heart_ventricle	0.76090767
91	MP0009764_decreased_sensitivity_to	0.76067356
92	MP0001963_abnormal_hearing_physiology	0.75377353
93	MP0005379_endocrine/exocrine_gland_phen	0.74737076
94	MP0003938_abnormal_ear_development	0.74179236
95	MP0010386_abnormal_urinary_bladder	0.73791645
96	MP0002277_abnormal_respiratory_mucosa	0.73790763
97	MP0005391_vision/eye_phenotype	0.73004027
98	MP0001502_abnormal_circadian_rhythm	0.71731276
99	MP0001542_abnormal_bone_strength	0.71367627
100	MP0002229_neurodegeneration	0.71357738

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.89683415
2	Molar tooth sign on MRI (HP:0002419)	3.77533103
3	Abnormality of midbrain morphology (HP:0002418)	3.77533103
4	Myokymia (HP:0002411)	3.69707677
5	Mitochondrial inheritance (HP:0001427)	3.54002752
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.46189056
7	Acute encephalopathy (HP:0006846)	3.42685422
8	Pancreatic fibrosis (HP:0100732)	3.32531101
9	Abolished electroretinogram (ERG) (HP:0000550)	3.26589949
10	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.17598880
11	Progressive macrocephaly (HP:0004481)	3.11530053
12	3-Methylglutaconic aciduria (HP:0003535)	3.09905737
13	Agitation (HP:0000713)	3.09223358
14	Pancreatic cysts (HP:0001737)	3.05859176
15	Increased CSF lactate (HP:0002490)	3.00097306
16	Hepatocellular necrosis (HP:0001404)	2.99711366
17	Pendular nystagmus (HP:0012043)	2.97087409
18	Medial flaring of the eyebrow (HP:0010747)	2.89311882
19	Reticulocytopenia (HP:0001896)	2.84955471
20	Lipid accumulation in hepatocytes (HP:0006561)	2.83719503
21	Increased hepatocellular lipid droplets (HP:0006565)	2.83380268
22	True hermaphroditism (HP:0010459)	2.82345447
23	Optic disc pallor (HP:0000543)	2.76802807
24	Congenital stationary night blindness (HP:0007642)	2.76512461
25	Gait imbalance (HP:0002141)	2.70176553
26	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.66942179
27	Nephronophthisis (HP:0000090)	2.66564458
28	Type 2 muscle fiber atrophy (HP:0003554)	2.66357808
29	Hepatic necrosis (HP:0002605)	2.61469115
30	Abnormal rod and cone electroretinograms (HP:0008323)	2.60114621
31	Hyperglycinemia (HP:0002154)	2.59893514
32	Lissencephaly (HP:0001339)	2.58130118
33	Type II lissencephaly (HP:0007260)	2.56709710
34	Aplastic anemia (HP:0001915)	2.55410990
35	Elevated erythrocyte sedimentation rate (HP:0003565)	2.54835810
36	Chronic hepatic failure (HP:0100626)	2.52992803
37	Failure to thrive in infancy (HP:0001531)	2.51915678
38	Cerebral edema (HP:0002181)	2.48922750
39	Congenital primary aphakia (HP:0007707)	2.43637755
40	Colon cancer (HP:0003003)	2.41292571
41	Abnormality of cells of the erythroid lineage (HP:0012130)	2.38277848
42	Decreased central vision (HP:0007663)	2.37283825
43	Sclerocornea (HP:0000647)	2.36812400
44	Nephrogenic diabetes insipidus (HP:0009806)	2.35143255
45	Limb dystonia (HP:0002451)	2.33550863
46	Abnormal respiratory epithelium morphology (HP:0012253)	2.33039743
47	Abnormal respiratory motile cilium morphology (HP:0005938)	2.33039743
48	Muscle fiber atrophy (HP:0100295)	2.32981038
49	Polyphagia (HP:0002591)	2.31893365
50	Pachygyria (HP:0001302)	2.31268235
51	Methylmalonic acidemia (HP:0002912)	2.30603341
52	Increased intramyocellular lipid droplets (HP:0012240)	2.29165536
53	Absent/shortened dynein arms (HP:0200106)	2.27358478
54	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.27358478
55	Abnormality of the labia minora (HP:0012880)	2.23420409
56	Retinal dysplasia (HP:0007973)	2.22756392
57	Severe combined immunodeficiency (HP:0004430)	2.22538575
58	Renal Fanconi syndrome (HP:0001994)	2.22368749
59	Attenuation of retinal blood vessels (HP:0007843)	2.20370201
60	Methylmalonic aciduria (HP:0012120)	2.19514018
61	IgG deficiency (HP:0004315)	2.17185002
62	Abnormality of the renal medulla (HP:0100957)	2.16979682
63	Lactic acidosis (HP:0003128)	2.15103522
64	Postaxial foot polydactyly (HP:0001830)	2.11236078
65	Increased serum lactate (HP:0002151)	2.10162074
66	Anencephaly (HP:0002323)	2.05136425
67	Abnormality of alanine metabolism (HP:0010916)	2.04859217
68	Hyperalaninemia (HP:0003348)	2.04859217
69	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.04859217
70	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.03673594
71	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.03673594
72	Increased muscle lipid content (HP:0009058)	1.99542821
73	Genital tract atresia (HP:0001827)	1.92471445
74	Abnormality of the renal cortex (HP:0011035)	1.92177887
75	Vaginal atresia (HP:0000148)	1.91758136
76	Exertional dyspnea (HP:0002875)	1.90441343
77	Keratoconus (HP:0000563)	1.90340194
78	Increased corneal curvature (HP:0100692)	1.90340194
79	Cystic liver disease (HP:0006706)	1.89471392
80	Abnormal number of erythroid precursors (HP:0012131)	1.84292312
81	Macrocytic anemia (HP:0001972)	1.83368114
82	Lethargy (HP:0001254)	1.81127897
83	Chorioretinal atrophy (HP:0000533)	1.79718629
84	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.78367499
85	Renal cortical cysts (HP:0000803)	1.77949964
86	Hypoproteinemia (HP:0003075)	1.77023774
87	Progressive cerebellar ataxia (HP:0002073)	1.76350222
88	Pancytopenia (HP:0001876)	1.75549123
89	Cerebellar dysplasia (HP:0007033)	1.73466115
90	Large eyes (HP:0001090)	1.72615614
91	Abnormal ciliary motility (HP:0012262)	1.72215718
92	Narrow forehead (HP:0000341)	1.71185923
93	Bony spicule pigmentary retinopathy (HP:0007737)	1.70944399
94	Postaxial hand polydactyly (HP:0001162)	1.70810158
95	Retinitis pigmentosa (HP:0000510)	1.70774587
96	Thyroid-stimulating hormone excess (HP:0002925)	1.70515841
97	Asplenia (HP:0001746)	1.70424095
98	Thyroiditis (HP:0100646)	1.69210516
99	Abnormal respiratory motile cilium physiology (HP:0012261)	1.69018865
100	Male pseudohermaphroditism (HP:0000037)	1.68649041

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	3.92064748
2	BCKDK	3.13575396
3	TLK1	3.03389433
4	TXK	2.94436141
5	ZAK	2.71112021
6	ADRBK2	2.55834508
7	WNK4	2.53266526
8	MAP2K7	2.50214140
9	STK16	2.45480302
10	DYRK2	2.35893065
11	PINK1	2.32672573
12	NUAK1	2.32148533
13	MAP4K2	2.26432442
14	CDK19	2.21348554
15	WNK3	2.02941939
16	MAPK13	1.90668593
17	CAMKK2	1.81752740
18	MARK1	1.81533106
19	KDR	1.69553897
20	MAP3K4	1.64732484
21	GRK1	1.62926652
22	CASK	1.47357292
23	TNK2	1.46306582
24	BCR	1.41275654
25	MAP4K1	1.28545187
26	ITK	1.25678669
27	TESK2	1.25376939
28	VRK1	1.24677984
29	MINK1	1.24389522
30	SIK2	1.21906018
31	NTRK2	1.19067110
32	TYRO3	1.06188072
33	TIE1	1.05393469
34	CAMKK1	1.04654982
35	PRKCQ	1.03891145
36	DYRK3	1.03236534
37	LIMK1	1.02260591
38	RPS6KA4	1.02114883
39	DYRK1B	1.01898720
40	CSNK1G3	0.99541598
41	OXSR1	0.99238954
42	FES	0.98000142
43	PRKCG	0.97907377
44	CSNK1G2	0.97884236
45	PIK3CA	0.97760242
46	FRK	0.92466965
47	GRK7	0.88048743
48	MAP3K11	0.84101373
49	VRK2	0.83863886
50	PAK3	0.83781119
51	ADRBK1	0.79359065
52	STK39	0.75045360
53	ERBB3	0.73851660
54	CAMK1	0.72565593
55	PLK2	0.71892419
56	CSNK1A1L	0.70932386
57	TRIM28	0.68977026
58	KIT	0.68946233
59	RPS6KA5	0.68099303
60	DYRK1A	0.67034238
61	CAMK2A	0.65731347
62	PRKACA	0.65422382
63	EPHA4	0.64744280
64	BMPR1B	0.64453518
65	INSRR	0.63519868
66	SYK	0.60144141
67	CSNK1G1	0.59698492
68	PIM2	0.56739868
69	CDK14	0.55998143
70	PRKCE	0.55477701
71	MAPKAPK3	0.55245579
72	PHKG1	0.53143702
73	PHKG2	0.53143702
74	PAK6	0.52572906
75	PKN1	0.51026702
76	OBSCN	0.50540474
77	PRKCA	0.50513756
78	LCK	0.49947841
79	CSNK1A1	0.49516469
80	SRPK1	0.49430025
81	TEC	0.45747232
82	PRKCI	0.45527484
83	BTK	0.43315456
84	PRKCH	0.42950489
85	AURKA	0.41504301
86	STK11	0.41481556
87	CDK5	0.41419787
88	DAPK2	0.41115517
89	IKBKB	0.40136174
90	PRKCD	0.39779700
91	CSNK2A2	0.39126316
92	PRKACG	0.36696425
93	DAPK1	0.35381434
94	PRKACB	0.34065701
95	PRKD3	0.33910800
96	CDK15	0.33301898
97	CDK11A	0.33164770
98	CDK18	0.32423355
99	CSF1R	0.31001306
100	LYN	0.30715803

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.11124560
2	Parkinsons disease_Homo sapiens_hsa05012	3.58036356
3	Ribosome_Homo sapiens_hsa03010	3.02671980
4	Cardiac muscle contraction_Homo sapiens_hsa04260	2.64409686
5	Alzheimers disease_Homo sapiens_hsa05010	2.35231559
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.25512974
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.19712828
8	Nicotine addiction_Homo sapiens_hsa05033	2.16260887
9	Protein export_Homo sapiens_hsa03060	2.16249591
10	Phototransduction_Homo sapiens_hsa04744	2.11694462
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.10830766
12	Huntingtons disease_Homo sapiens_hsa05016	2.09506074
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.96422211
14	RNA polymerase_Homo sapiens_hsa03020	1.95828874
15	Primary immunodeficiency_Homo sapiens_hsa05340	1.90395408
16	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.89645279
17	Proteasome_Homo sapiens_hsa03050	1.85656271
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.85479926
19	Asthma_Homo sapiens_hsa05310	1.80524348
20	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.79701207
21	Allograft rejection_Homo sapiens_hsa05330	1.78119654
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.76956678
23	Graft-versus-host disease_Homo sapiens_hsa05332	1.66479280
24	Type I diabetes mellitus_Homo sapiens_hsa04940	1.59227864
25	Butanoate metabolism_Homo sapiens_hsa00650	1.56630243
26	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.51962026
27	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.49712175
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.47267167
29	Steroid biosynthesis_Homo sapiens_hsa00100	1.36791600
30	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.31910649
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.31038551
32	Tryptophan metabolism_Homo sapiens_hsa00380	1.20190274
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.18644783
34	Propanoate metabolism_Homo sapiens_hsa00640	1.13719223
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.12280385
36	Peroxisome_Homo sapiens_hsa04146	1.10709421
37	Morphine addiction_Homo sapiens_hsa05032	1.09867402
38	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.09435156
39	Rheumatoid arthritis_Homo sapiens_hsa05323	1.08530187
40	Basal transcription factors_Homo sapiens_hsa03022	1.04855130
41	Caffeine metabolism_Homo sapiens_hsa00232	1.00126388
42	Collecting duct acid secretion_Homo sapiens_hsa04966	0.96103899
43	GABAergic synapse_Homo sapiens_hsa04727	0.93954450
44	Antigen processing and presentation_Homo sapiens_hsa04612	0.92069327
45	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.87892625
46	Olfactory transduction_Homo sapiens_hsa04740	0.87580027
47	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.86864128
48	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.85370342
49	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.84461226
50	Taste transduction_Homo sapiens_hsa04742	0.84399349
51	Regulation of autophagy_Homo sapiens_hsa04140	0.81862595
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.81029392
53	RNA degradation_Homo sapiens_hsa03018	0.79523619
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.79096277
55	Fanconi anemia pathway_Homo sapiens_hsa03460	0.76604665
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76387230
57	Homologous recombination_Homo sapiens_hsa03440	0.73587088
58	Glutamatergic synapse_Homo sapiens_hsa04724	0.73173824
59	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.72961124
60	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.72552495
61	Serotonergic synapse_Homo sapiens_hsa04726	0.71505429
62	Circadian entrainment_Homo sapiens_hsa04713	0.71497553
63	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.70775449
64	Pyrimidine metabolism_Homo sapiens_hsa00240	0.70735067
65	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.69476741
66	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.68431537
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.65956565
68	Fatty acid elongation_Homo sapiens_hsa00062	0.65774875
69	Mismatch repair_Homo sapiens_hsa03430	0.65368098
70	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.64282920
71	Metabolic pathways_Homo sapiens_hsa01100	0.61691953
72	One carbon pool by folate_Homo sapiens_hsa00670	0.60909704
73	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60709827
74	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.58950312
75	Dopaminergic synapse_Homo sapiens_hsa04728	0.58347054
76	Purine metabolism_Homo sapiens_hsa00230	0.56299784
77	Nucleotide excision repair_Homo sapiens_hsa03420	0.55876536
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.54591508
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.54522422
80	Selenocompound metabolism_Homo sapiens_hsa00450	0.49652140
81	Retinol metabolism_Homo sapiens_hsa00830	0.49318536
82	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.48697718
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45903278
84	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.44687202
85	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.41968565
86	beta-Alanine metabolism_Homo sapiens_hsa00410	0.40147758
87	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.38072160
88	Insulin secretion_Homo sapiens_hsa04911	0.37596150
89	Salivary secretion_Homo sapiens_hsa04970	0.32530673
90	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.32325779
91	Alcoholism_Homo sapiens_hsa05034	0.31487003
92	Viral myocarditis_Homo sapiens_hsa05416	0.29441604
93	Axon guidance_Homo sapiens_hsa04360	0.28636806
94	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.28369386
95	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.27938813
96	Base excision repair_Homo sapiens_hsa03410	0.27638423
97	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.27466982
98	Cholinergic synapse_Homo sapiens_hsa04725	0.27276879
99	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.26596919
100	Amphetamine addiction_Homo sapiens_hsa05031	0.25839332

H3F3AP5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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