H3F3AP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.32270770
2protein neddylation (GO:0045116)5.80170568
3cytidine deamination (GO:0009972)5.61898231
4cytidine metabolic process (GO:0046087)5.61898231
5cytidine catabolic process (GO:0006216)5.61898231
6sequestering of actin monomers (GO:0042989)5.29398318
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.04347261
8pyrimidine ribonucleoside catabolic process (GO:0046133)4.84583832
9behavioral response to nicotine (GO:0035095)4.68523043
10cornea development in camera-type eye (GO:0061303)4.46864954
11platelet dense granule organization (GO:0060155)3.95810881
12ATP synthesis coupled proton transport (GO:0015986)3.76454468
13energy coupled proton transport, down electrochemical gradient (GO:0015985)3.76454468
14Arp2/3 complex-mediated actin nucleation (GO:0034314)3.66894875
15regulation of cilium movement (GO:0003352)3.56303313
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.39918585
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.33839757
18mannosylation (GO:0097502)3.30880695
19actin nucleation (GO:0045010)3.28446679
20RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.25416034
21tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.25416034
22pyrimidine nucleobase catabolic process (GO:0006208)3.19852527
23axoneme assembly (GO:0035082)3.18612175
24electron transport chain (GO:0022900)3.18395558
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.17068197
26ubiquinone biosynthetic process (GO:0006744)3.16726867
27respiratory electron transport chain (GO:0022904)3.13303906
28positive regulation of defense response to virus by host (GO:0002230)3.06137005
29negative regulation of mast cell activation (GO:0033004)3.06065987
30iron-sulfur cluster assembly (GO:0016226)3.05680478
31metallo-sulfur cluster assembly (GO:0031163)3.05680478
32protein complex biogenesis (GO:0070271)3.00012453
33glyoxylate metabolic process (GO:0046487)2.96091428
34ribosomal small subunit assembly (GO:0000028)2.95154097
35pyrimidine-containing compound catabolic process (GO:0072529)2.92155623
36deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.91586643
37ubiquinone metabolic process (GO:0006743)2.90502737
38response to pheromone (GO:0019236)2.87622133
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.85191684
40negative regulation of T cell apoptotic process (GO:0070233)2.80379589
41piRNA metabolic process (GO:0034587)2.79862239
42dopamine transport (GO:0015872)2.79668848
43cytolysis (GO:0019835)2.79024911
44chaperone-mediated protein transport (GO:0072321)2.76847871
45pyrimidine nucleoside catabolic process (GO:0046135)2.76647427
46transcription elongation from RNA polymerase III promoter (GO:0006385)2.76458025
47termination of RNA polymerase III transcription (GO:0006386)2.76458025
48protein polyglutamylation (GO:0018095)2.75372284
49pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.72065131
50positive regulation of cell fate commitment (GO:0010455)2.70014792
51sulfation (GO:0051923)2.68056281
52negative regulation of telomere maintenance (GO:0032205)2.67371035
53photoreceptor cell maintenance (GO:0045494)2.67204662
54negative regulation of transcription regulatory region DNA binding (GO:2000678)2.65860224
55establishment of mitochondrion localization (GO:0051654)2.65477714
56epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.65034431
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.64365785
58DNA demethylation (GO:0080111)2.63673881
59negative regulation by host of viral transcription (GO:0043922)2.60190978
60positive regulation of interleukin-8 secretion (GO:2000484)2.60135909
61positive regulation of mitochondrial fission (GO:0090141)2.58825146
62preassembly of GPI anchor in ER membrane (GO:0016254)2.58449055
63mitochondrial respiratory chain complex assembly (GO:0033108)2.55903421
64GPI anchor metabolic process (GO:0006505)2.55761882
65detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.52786088
66substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.52624201
67substrate-independent telencephalic tangential migration (GO:0021826)2.52624201
68synaptic transmission, cholinergic (GO:0007271)2.52386657
69negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.52264241
70negative regulation of appetite (GO:0032099)2.51029322
71negative regulation of response to food (GO:0032096)2.51029322
72hydrogen ion transmembrane transport (GO:1902600)2.50874246
73nucleobase catabolic process (GO:0046113)2.50418384
74quinone biosynthetic process (GO:1901663)2.49493399
75regulation of cellular amino acid metabolic process (GO:0006521)2.49348472
76positive regulation of calcium-mediated signaling (GO:0050850)2.48249131
77nonmotile primary cilium assembly (GO:0035058)2.47226748
78regulation of microtubule-based movement (GO:0060632)2.46772471
79negative regulation of lymphocyte apoptotic process (GO:0070229)2.46416782
80transmission of nerve impulse (GO:0019226)2.46159093
81cell proliferation in forebrain (GO:0021846)2.45059981
82NADH dehydrogenase complex assembly (GO:0010257)2.43317866
83mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.43317866
84mitochondrial respiratory chain complex I assembly (GO:0032981)2.43317866
85DNA dealkylation (GO:0035510)2.42036669
86proton transport (GO:0015992)2.39620669
87establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.38772781
88mitochondrion transport along microtubule (GO:0047497)2.38772781
89DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.37968739
90somite development (GO:0061053)2.37468948
91regulation of activation of Janus kinase activity (GO:0010533)2.35911401
92GPI anchor biosynthetic process (GO:0006506)2.35247716
93hydrogen transport (GO:0006818)2.34411523
94negative regulation of heart rate (GO:0010459)2.34295878
95epithelial cilium movement (GO:0003351)2.33985204
96negative regulation of cytosolic calcium ion concentration (GO:0051481)2.30943488
97regulation of action potential (GO:0098900)2.30111519
98regulation of regulatory T cell differentiation (GO:0045589)2.29501447
99signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.29207334
100signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.29207334

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.43359627
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.29990749
3ZNF274_21170338_ChIP-Seq_K562_Hela3.24527957
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.11453289
5IGF1R_20145208_ChIP-Seq_DFB_Human2.82517158
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.69954100
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45891003
8VDR_22108803_ChIP-Seq_LS180_Human2.44523469
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.38547613
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.28110125
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20080831
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.18455514
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.08975036
14LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.01830410
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.93416900
16EST1_17652178_ChIP-ChIP_JURKAT_Human1.90264404
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86158950
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81078265
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.59501912
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59397814
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.58213492
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53408197
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50379358
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.50115800
25VDR_23849224_ChIP-Seq_CD4+_Human1.49342877
26MYC_18940864_ChIP-ChIP_HL60_Human1.48399633
27EWS_26573619_Chip-Seq_HEK293_Human1.47412631
28TP53_22573176_ChIP-Seq_HFKS_Human1.47341786
29REST_21632747_ChIP-Seq_MESCs_Mouse1.47058123
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45012819
31GBX2_23144817_ChIP-Seq_PC3_Human1.40199871
32P300_19829295_ChIP-Seq_ESCs_Human1.39902077
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38895535
34NANOG_19829295_ChIP-Seq_ESCs_Human1.33537268
35SOX2_19829295_ChIP-Seq_ESCs_Human1.33537268
36NANOG_20526341_ChIP-Seq_ESCs_Human1.33417803
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.32681111
38GATA3_21878914_ChIP-Seq_MCF-7_Human1.32133961
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31985526
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.30505002
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.29202169
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29202169
43ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28464661
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28127621
45HTT_18923047_ChIP-ChIP_STHdh_Human1.27844070
46RNF2_27304074_Chip-Seq_NSC_Mouse1.27824920
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27211471
48PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.26968628
49AR_20517297_ChIP-Seq_VCAP_Human1.26618591
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26197674
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.25786636
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.25296283
53RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.24399197
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20385591
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.20186586
56IRF1_19129219_ChIP-ChIP_H3396_Human1.20009924
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19374637
58NCOR_22424771_ChIP-Seq_293T_Human1.18133927
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16518259
60EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16343777
61STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.15865579
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15779668
63ERA_21632823_ChIP-Seq_H3396_Human1.15754426
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15544345
65ER_23166858_ChIP-Seq_MCF-7_Human1.14427919
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12364992
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12357961
68CBP_20019798_ChIP-Seq_JUKART_Human1.12357961
69TAF2_19829295_ChIP-Seq_ESCs_Human1.12065684
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11504177
71REST_18959480_ChIP-ChIP_MESCs_Mouse1.11468868
72CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10259674
73MYC_19829295_ChIP-Seq_ESCs_Human1.09060674
74IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08594116
75FOXP3_21729870_ChIP-Seq_TREG_Human1.08092599
76CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07838458
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07483131
78BCAT_22108803_ChIP-Seq_LS180_Human1.07105809
79TAF15_26573619_Chip-Seq_HEK293_Human1.04785350
80AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02925149
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01835590
82FOXH1_21741376_ChIP-Seq_EPCs_Human1.01657277
83ELK1_19687146_ChIP-ChIP_HELA_Human1.01572948
84P53_21459846_ChIP-Seq_SAOS-2_Human1.01244788
85TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01162216
86PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.00345621
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00149288
88BCL6_27268052_Chip-Seq_Bcells_Human1.00004110
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00003395
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99570393
91NOTCH1_21737748_ChIP-Seq_TLL_Human0.99184518
92EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98845471
93EZH2_27304074_Chip-Seq_ESCs_Mouse0.98147321
94PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96539183
95EED_16625203_ChIP-ChIP_MESCs_Mouse0.96389869
96JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95790237
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.94890710
98EZH2_27294783_Chip-Seq_ESCs_Mouse0.94234483
99CIITA_25753668_ChIP-Seq_RAJI_Human0.93843961
100GATA3_26560356_Chip-Seq_TH2_Human0.92958493

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.21317066
2MP0003787_abnormal_imprinting3.79372459
3MP0005646_abnormal_pituitary_gland3.09673342
4MP0008789_abnormal_olfactory_epithelium3.06374282
5MP0005671_abnormal_response_to2.86506706
6MP0002638_abnormal_pupillary_reflex2.72151975
7MP0005499_abnormal_olfactory_system2.61371493
8MP0005394_taste/olfaction_phenotype2.61371493
9MP0002653_abnormal_ependyma_morphology2.58034677
10MP0002822_catalepsy2.54878218
11MP0008877_abnormal_DNA_methylation2.47283409
12MP0006276_abnormal_autonomic_nervous2.44845130
13MP0001485_abnormal_pinna_reflex2.37127857
14MP0001529_abnormal_vocalization2.36615348
15MP0002102_abnormal_ear_morphology2.25352314
16MP0005645_abnormal_hypothalamus_physiol2.16223539
17MP0003880_abnormal_central_pattern1.93161666
18MP0006072_abnormal_retinal_apoptosis1.88280233
19MP0003646_muscle_fatigue1.82788186
20MP0004147_increased_porphyrin_level1.74177785
21MP0001968_abnormal_touch/_nociception1.70164745
22MP0004142_abnormal_muscle_tone1.67361420
23MP0001905_abnormal_dopamine_level1.67028597
24MP0003121_genomic_imprinting1.61784096
25MP0001188_hyperpigmentation1.61487676
26MP0005551_abnormal_eye_electrophysiolog1.59463472
27MP0010386_abnormal_urinary_bladder1.54696644
28MP0002160_abnormal_reproductive_system1.53560687
29MP0004885_abnormal_endolymph1.53352030
30MP0005084_abnormal_gallbladder_morpholo1.52961623
31MP0004742_abnormal_vestibular_system1.49924031
32MP0008872_abnormal_physiological_respon1.42862745
33MP0005253_abnormal_eye_physiology1.40227297
34MP0002736_abnormal_nociception_after1.38217293
35MP0005167_abnormal_blood-brain_barrier1.36163602
36MP0009745_abnormal_behavioral_response1.36081352
37MP0005410_abnormal_fertilization1.33181249
38MP0009785_altered_susceptibility_to1.31962717
39MP0002272_abnormal_nervous_system1.31924998
40MP0009764_decreased_sensitivity_to1.28481660
41MP0009046_muscle_twitch1.28442279
42MP0005389_reproductive_system_phenotype1.27702524
43MP0001984_abnormal_olfaction1.25689061
44MP0001835_abnormal_antigen_presentation1.25044111
45MP0000372_irregular_coat_pigmentation1.21981862
46MP0003011_delayed_dark_adaptation1.21666930
47MP0000631_abnormal_neuroendocrine_gland1.21477972
48MP0001919_abnormal_reproductive_system1.21279687
49MP0002876_abnormal_thyroid_physiology1.20900058
50MP0002163_abnormal_gland_morphology1.17721002
51MP0002735_abnormal_chemical_nociception1.17563220
52MP0001970_abnormal_pain_threshold1.15542262
53MP0002148_abnormal_hypersensitivity_rea1.13486466
54MP0001986_abnormal_taste_sensitivity1.12788877
55MP0002733_abnormal_thermal_nociception1.11296671
56MP0005464_abnormal_platelet_physiology1.08358348
57MP0000778_abnormal_nervous_system1.04800721
58MP0002909_abnormal_adrenal_gland1.04708019
59MP0001486_abnormal_startle_reflex1.04232820
60MP0003878_abnormal_ear_physiology1.03416686
61MP0005377_hearing/vestibular/ear_phenot1.03416686
62MP0005423_abnormal_somatic_nervous1.01158657
63MP0002557_abnormal_social/conspecific_i0.97822891
64MP0002572_abnormal_emotion/affect_behav0.97009250
65MP0002138_abnormal_hepatobiliary_system0.96024149
66MP0000230_abnormal_systemic_arterial0.95300617
67MP0009379_abnormal_foot_pigmentation0.93974450
68MP0002277_abnormal_respiratory_mucosa0.92780556
69MP0003866_abnormal_defecation0.90286499
70MP0005195_abnormal_posterior_eye0.89426723
71MP0001963_abnormal_hearing_physiology0.89332639
72MP0003122_maternal_imprinting0.88925588
73MP0004145_abnormal_muscle_electrophysio0.87891450
74MP0003635_abnormal_synaptic_transmissio0.86871136
75MP0001800_abnormal_humoral_immune0.86480965
76MP0000026_abnormal_inner_ear0.85440239
77MP0002752_abnormal_somatic_nervous0.85260221
78MP0002067_abnormal_sensory_capabilities0.83489369
79MP0005025_abnormal_response_to0.80936003
80MP0004924_abnormal_behavior0.79787425
81MP0005386_behavior/neurological_phenoty0.79787425
82MP0002420_abnormal_adaptive_immunity0.79620931
83MP0002723_abnormal_immune_serum0.78900163
84MP0003567_abnormal_fetal_cardiomyocyte0.78214314
85MP0002938_white_spotting0.77889031
86MP0005000_abnormal_immune_tolerance0.76118800
87MP0001819_abnormal_immune_cell0.75986157
88MP0002064_seizures0.75677363
89MP0006036_abnormal_mitochondrial_physio0.74949733
90MP0003724_increased_susceptibility_to0.74712728
91MP0002063_abnormal_learning/memory/cond0.74215835
92MP0008995_early_reproductive_senescence0.72497956
93MP0004133_heterotaxia0.72246458
94MP0002837_dystrophic_cardiac_calcinosis0.70080405
95MP0003763_abnormal_thymus_physiology0.69935078
96MP0003137_abnormal_impulse_conducting0.69283468
97MP0000049_abnormal_middle_ear0.69152133
98MP0002734_abnormal_mechanical_nocicepti0.68591185
99MP0003879_abnormal_hair_cell0.67035068
100MP0001119_abnormal_female_reproductive0.66098425

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)3.77732118
2Acute necrotizing encephalopathy (HP:0006965)3.70617270
33-Methylglutaconic aciduria (HP:0003535)3.69973952
4Elevated erythrocyte sedimentation rate (HP:0003565)3.59057680
5Abnormal mitochondria in muscle tissue (HP:0008316)3.42154059
6Mitochondrial inheritance (HP:0001427)3.40811916
7Abolished electroretinogram (ERG) (HP:0000550)3.39250188
8Abnormality of midbrain morphology (HP:0002418)3.29004836
9Molar tooth sign on MRI (HP:0002419)3.29004836
10Acute encephalopathy (HP:0006846)3.28583857
11Congenital stationary night blindness (HP:0007642)3.21184636
12Pendular nystagmus (HP:0012043)3.14279417
13Pancreatic cysts (HP:0001737)3.06051281
14Severe combined immunodeficiency (HP:0004430)3.04562890
15Progressive macrocephaly (HP:0004481)3.02173045
16Aplastic anemia (HP:0001915)3.01748810
17Decreased electroretinogram (ERG) amplitude (HP:0000654)2.93017371
18True hermaphroditism (HP:0010459)2.92109969
19Abnormal rod and cone electroretinograms (HP:0008323)2.91495681
20Hypoplasia of the fovea (HP:0007750)2.88691400
21Aplasia/Hypoplasia of the fovea (HP:0008060)2.88691400
22Hypoproteinemia (HP:0003075)2.83782106
23Hepatocellular necrosis (HP:0001404)2.83243656
24Pancreatic fibrosis (HP:0100732)2.82419497
25Increased CSF lactate (HP:0002490)2.82033219
26Type II lissencephaly (HP:0007260)2.74749178
27Abnormality of the fovea (HP:0000493)2.72125375
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.71817008
29Decreased activity of mitochondrial respiratory chain (HP:0008972)2.71817008
30Thyroiditis (HP:0100646)2.70642703
31Hepatic necrosis (HP:0002605)2.67519273
32Optic disc pallor (HP:0000543)2.64452392
33Increased IgM level (HP:0003496)2.63196638
34Decreased central vision (HP:0007663)2.61469792
35Attenuation of retinal blood vessels (HP:0007843)2.60643771
36Increased hepatocellular lipid droplets (HP:0006565)2.57291025
37Increased intramyocellular lipid droplets (HP:0012240)2.56033372
38Lissencephaly (HP:0001339)2.54114741
39Medial flaring of the eyebrow (HP:0010747)2.48401425
40Retinal dysplasia (HP:0007973)2.46912844
41IgG deficiency (HP:0004315)2.45278717
42Renal Fanconi syndrome (HP:0001994)2.45135814
43Abnormal respiratory motile cilium morphology (HP:0005938)2.42355770
44Abnormal respiratory epithelium morphology (HP:0012253)2.42355770
45Lipid accumulation in hepatocytes (HP:0006561)2.41376056
46Hyperglycinemia (HP:0002154)2.39612625
47Broad-based gait (HP:0002136)2.32988061
48Reticulocytopenia (HP:0001896)2.31583872
49Cerebral edema (HP:0002181)2.29971304
50Optic nerve coloboma (HP:0000588)2.28423398
51Renal cortical cysts (HP:0000803)2.22675829
52Combined immunodeficiency (HP:0005387)2.22205136
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.18240874
54Absent/shortened dynein arms (HP:0200106)2.18240874
55Optic nerve hypoplasia (HP:0000609)2.16331192
56Increased muscle lipid content (HP:0009058)2.15743663
57Stomatitis (HP:0010280)2.15433375
58Abnormality of the renal cortex (HP:0011035)2.13503312
59Agitation (HP:0000713)2.12807866
60Gait imbalance (HP:0002141)2.12369914
61Abnormality of B cell number (HP:0010975)2.10486413
62Panhypogammaglobulinemia (HP:0003139)2.10252196
63Generalized aminoaciduria (HP:0002909)2.07755417
64Abnormality of the labia minora (HP:0012880)2.07387664
65Methylmalonic aciduria (HP:0012120)2.05259492
66Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.04868365
67Abnormality of eosinophils (HP:0001879)2.01097567
68Congenital primary aphakia (HP:0007707)2.01076673
69Myokymia (HP:0002411)1.99663463
70Pancytopenia (HP:0001876)1.99167505
71T lymphocytopenia (HP:0005403)1.99054711
72B lymphocytopenia (HP:0010976)1.97619495
73Pachygyria (HP:0001302)1.94148911
74Dicarboxylic aciduria (HP:0003215)1.93524579
75Abnormality of dicarboxylic acid metabolism (HP:0010995)1.93524579
76Amyotrophic lateral sclerosis (HP:0007354)1.93450354
77Increased serum lactate (HP:0002151)1.93387678
78Lactic acidosis (HP:0003128)1.91405674
79Constricted visual fields (HP:0001133)1.89151965
80Cerebral palsy (HP:0100021)1.88569693
81Abnormality of the prostate (HP:0008775)1.87390794
82Sclerocornea (HP:0000647)1.86889289
83Increased corneal curvature (HP:0100692)1.85161894
84Keratoconus (HP:0000563)1.85161894
85Abnormality of T cell number (HP:0011839)1.84013319
86Nephrogenic diabetes insipidus (HP:0009806)1.83735360
87Cerebellar dysplasia (HP:0007033)1.78820519
88Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.77683639
89Petechiae (HP:0000967)1.76032914
90Nephronophthisis (HP:0000090)1.73796869
91Bony spicule pigmentary retinopathy (HP:0007737)1.71364607
92Hypomagnesemia (HP:0002917)1.71235249
93Exertional dyspnea (HP:0002875)1.70587895
94Vaginal atresia (HP:0000148)1.69680948
95Aplasia/hypoplasia of the uterus (HP:0008684)1.69276748
96Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.68624500
97Male pseudohermaphroditism (HP:0000037)1.67633371
98Cystic liver disease (HP:0006706)1.67172689
99Adrenal hypoplasia (HP:0000835)1.67049125
100Type 2 muscle fiber atrophy (HP:0003554)1.66712979

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR3.97605485
2TESK23.89766583
3TXK3.20472083
4WNK32.84700844
5ADRBK22.78857804
6VRK22.78603637
7MAP4K22.59952552
8SIK22.59703613
9ZAK2.56345861
10BCKDK2.28078701
11GRK12.22408715
12DYRK22.18276442
13CDK192.13467225
14LIMK12.10988265
15FRK2.09261816
16MAPK132.09126246
17TAOK31.95806422
18MAP4K11.93094734
19PINK11.76903589
20MAP2K71.67032334
21CASK1.63743952
22WNK41.62895215
23VRK11.62704319
24TLK11.51282506
25TESK11.45294857
26STK161.38095179
27TRIM281.33513041
28TIE11.32706228
29MUSK1.32468868
30MARK11.30229465
31MAP3K41.25718298
32NUAK11.21568586
33DYRK31.16400813
34MAP3K111.12280172
35TEC1.08539585
36ITK1.08420186
37CSNK1G31.07251935
38RPS6KA41.02104366
39CSNK1G21.01819785
40SYK0.98890628
41INSRR0.96083928
42FES0.95326453
43BMPR1B0.89417013
44NEK20.88461207
45GRK70.88385158
46PRKCQ0.83764822
47CSNK1G10.83563525
48BCR0.82604430
49MINK10.80166211
50OXSR10.79095722
51STK390.77385586
52CSNK1A1L0.74958468
53PTK2B0.70734775
54TNK20.69149572
55RPS6KA50.68720788
56CDK80.67196732
57KIT0.63738644
58BTK0.63555648
59PIK3CG0.62245870
60ADRBK10.60462929
61DAPK10.60368415
62GRK50.60304839
63LYN0.59790735
64FLT30.57540507
65CSF1R0.56717814
66DAPK20.55736942
67SRPK10.54835381
68MATK0.54485342
69PRKCG0.54265648
70HIPK20.54129144
71MST40.49575334
72LCK0.48965604
73PIM20.47838444
74TNIK0.46080638
75PRKACA0.44065385
76DYRK1B0.43931747
77SCYL20.43205804
78EPHA30.43180576
79AURKA0.41313291
80BUB10.40468231
81MAP2K60.40459423
82PRKCA0.38192259
83IKBKB0.37901004
84ERBB30.37194820
85PLK40.36643692
86PKN10.35963673
87PRKCE0.35933182
88CSNK1A10.35832124
89OBSCN0.35331287
90LRRK20.34319328
91CAMK2A0.33949074
92NTRK20.33467655
93CSNK2A10.33387913
94WEE10.31939224
95DYRK1A0.31494497
96IRAK40.31382751
97PLK20.31050955
98GRK60.30887794
99MAPKAPK30.30156334
100ROCK10.28632085

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.82477407
2Parkinsons disease_Homo sapiens_hsa050123.52469183
3Primary immunodeficiency_Homo sapiens_hsa053403.40622815
4Proteasome_Homo sapiens_hsa030503.33781496
5Phototransduction_Homo sapiens_hsa047442.35522588
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.33738458
7Ribosome_Homo sapiens_hsa030102.27368042
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.25782840
9RNA polymerase_Homo sapiens_hsa030202.16553094
10Alzheimers disease_Homo sapiens_hsa050102.11700812
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.06302778
12Huntingtons disease_Homo sapiens_hsa050162.04778395
13Cardiac muscle contraction_Homo sapiens_hsa042601.89770583
14Graft-versus-host disease_Homo sapiens_hsa053321.84754720
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79809937
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.79542444
17Protein export_Homo sapiens_hsa030601.75918718
18Autoimmune thyroid disease_Homo sapiens_hsa053201.71982127
19Allograft rejection_Homo sapiens_hsa053301.70946445
20Hematopoietic cell lineage_Homo sapiens_hsa046401.62897640
21Peroxisome_Homo sapiens_hsa041461.59960798
22Nicotine addiction_Homo sapiens_hsa050331.59708710
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.59130659
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57216734
25Linoleic acid metabolism_Homo sapiens_hsa005911.44763473
26Type I diabetes mellitus_Homo sapiens_hsa049401.43509170
27Antigen processing and presentation_Homo sapiens_hsa046121.39235419
28Butanoate metabolism_Homo sapiens_hsa006501.39114389
29Asthma_Homo sapiens_hsa053101.28617888
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27839982
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27149547
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.16366610
33Nitrogen metabolism_Homo sapiens_hsa009101.16037739
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13825774
35Basal transcription factors_Homo sapiens_hsa030221.11254854
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.09065467
37Rheumatoid arthritis_Homo sapiens_hsa053231.07457208
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05633125
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05377202
40Olfactory transduction_Homo sapiens_hsa047401.03017533
41Collecting duct acid secretion_Homo sapiens_hsa049661.02724421
42Steroid biosynthesis_Homo sapiens_hsa001001.00575571
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98766698
44Steroid hormone biosynthesis_Homo sapiens_hsa001400.98307339
45Pyrimidine metabolism_Homo sapiens_hsa002400.97211959
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95801609
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94000361
48Morphine addiction_Homo sapiens_hsa050320.93433439
49Homologous recombination_Homo sapiens_hsa034400.92977798
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91447484
51Retinol metabolism_Homo sapiens_hsa008300.91084155
52RNA degradation_Homo sapiens_hsa030180.87758359
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87111461
54Propanoate metabolism_Homo sapiens_hsa006400.85460903
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83193142
56Regulation of autophagy_Homo sapiens_hsa041400.82143343
57Caffeine metabolism_Homo sapiens_hsa002320.79440613
58Fanconi anemia pathway_Homo sapiens_hsa034600.76949418
59Systemic lupus erythematosus_Homo sapiens_hsa053220.76324560
60Taste transduction_Homo sapiens_hsa047420.75412707
61Arachidonic acid metabolism_Homo sapiens_hsa005900.75188894
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74445963
63GABAergic synapse_Homo sapiens_hsa047270.71652200
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70879654
65One carbon pool by folate_Homo sapiens_hsa006700.67347121
66DNA replication_Homo sapiens_hsa030300.66985090
67Mismatch repair_Homo sapiens_hsa034300.65469955
68Chemical carcinogenesis_Homo sapiens_hsa052040.64417186
69Purine metabolism_Homo sapiens_hsa002300.62949790
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62810883
71Metabolic pathways_Homo sapiens_hsa011000.61796018
72T cell receptor signaling pathway_Homo sapiens_hsa046600.61360590
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61167971
74Viral myocarditis_Homo sapiens_hsa054160.60664258
75Base excision repair_Homo sapiens_hsa034100.60642789
76Ether lipid metabolism_Homo sapiens_hsa005650.59316187
77Salmonella infection_Homo sapiens_hsa051320.55799160
78Synaptic vesicle cycle_Homo sapiens_hsa047210.53233332
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52060828
80Tryptophan metabolism_Homo sapiens_hsa003800.51976000
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51253130
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50100683
83Alcoholism_Homo sapiens_hsa050340.49500910
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49189539
85Sulfur metabolism_Homo sapiens_hsa009200.46150343
86Circadian entrainment_Homo sapiens_hsa047130.43446270
87Serotonergic synapse_Homo sapiens_hsa047260.43347921
88Nucleotide excision repair_Homo sapiens_hsa034200.42455873
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40065192
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.38266007
91Fatty acid degradation_Homo sapiens_hsa000710.37258886
92Shigellosis_Homo sapiens_hsa051310.36381148
93Fat digestion and absorption_Homo sapiens_hsa049750.35361440
94Ovarian steroidogenesis_Homo sapiens_hsa049130.34433704
95Selenocompound metabolism_Homo sapiens_hsa004500.29265896
96Dopaminergic synapse_Homo sapiens_hsa047280.28839874
97Glutamatergic synapse_Homo sapiens_hsa047240.28389659
98Fatty acid elongation_Homo sapiens_hsa000620.28210102
99Folate biosynthesis_Homo sapiens_hsa007900.27784891
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24048350

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