ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.32270770
2	protein neddylation (GO:0045116)	5.80170568
3	cytidine deamination (GO:0009972)	5.61898231
4	cytidine metabolic process (GO:0046087)	5.61898231
5	cytidine catabolic process (GO:0006216)	5.61898231
6	sequestering of actin monomers (GO:0042989)	5.29398318
7	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.04347261
8	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.84583832
9	behavioral response to nicotine (GO:0035095)	4.68523043
10	cornea development in camera-type eye (GO:0061303)	4.46864954
11	platelet dense granule organization (GO:0060155)	3.95810881
12	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.76454468
13	ATP synthesis coupled proton transport (GO:0015986)	3.76454468
14	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.66894875
15	regulation of cilium movement (GO:0003352)	3.56303313
16	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.39918585
17	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.33839757
18	mannosylation (GO:0097502)	3.30880695
19	actin nucleation (GO:0045010)	3.28446679
20	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.25416034
21	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.25416034
22	pyrimidine nucleobase catabolic process (GO:0006208)	3.19852527
23	axoneme assembly (GO:0035082)	3.18612175
24	electron transport chain (GO:0022900)	3.18395558
25	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.17068197
26	ubiquinone biosynthetic process (GO:0006744)	3.16726867
27	respiratory electron transport chain (GO:0022904)	3.13303906
28	positive regulation of defense response to virus by host (GO:0002230)	3.06137005
29	negative regulation of mast cell activation (GO:0033004)	3.06065987
30	metallo-sulfur cluster assembly (GO:0031163)	3.05680478
31	iron-sulfur cluster assembly (GO:0016226)	3.05680478
32	protein complex biogenesis (GO:0070271)	3.00012453
33	glyoxylate metabolic process (GO:0046487)	2.96091428
34	ribosomal small subunit assembly (GO:0000028)	2.95154097
35	pyrimidine-containing compound catabolic process (GO:0072529)	2.92155623
36	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.91586643
37	ubiquinone metabolic process (GO:0006743)	2.90502737
38	response to pheromone (GO:0019236)	2.87622133
39	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.85191684
40	negative regulation of T cell apoptotic process (GO:0070233)	2.80379589
41	piRNA metabolic process (GO:0034587)	2.79862239
42	dopamine transport (GO:0015872)	2.79668848
43	cytolysis (GO:0019835)	2.79024911
44	chaperone-mediated protein transport (GO:0072321)	2.76847871
45	pyrimidine nucleoside catabolic process (GO:0046135)	2.76647427
46	termination of RNA polymerase III transcription (GO:0006386)	2.76458025
47	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.76458025
48	protein polyglutamylation (GO:0018095)	2.75372284
49	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.72065131
50	positive regulation of cell fate commitment (GO:0010455)	2.70014792
51	sulfation (GO:0051923)	2.68056281
52	negative regulation of telomere maintenance (GO:0032205)	2.67371035
53	photoreceptor cell maintenance (GO:0045494)	2.67204662
54	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.65860224
55	establishment of mitochondrion localization (GO:0051654)	2.65477714
56	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.65034431
57	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.64365785
58	DNA demethylation (GO:0080111)	2.63673881
59	negative regulation by host of viral transcription (GO:0043922)	2.60190978
60	positive regulation of interleukin-8 secretion (GO:2000484)	2.60135909
61	positive regulation of mitochondrial fission (GO:0090141)	2.58825146
62	preassembly of GPI anchor in ER membrane (GO:0016254)	2.58449055
63	mitochondrial respiratory chain complex assembly (GO:0033108)	2.55903421
64	GPI anchor metabolic process (GO:0006505)	2.55761882
65	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.52786088
66	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.52624201
67	substrate-independent telencephalic tangential migration (GO:0021826)	2.52624201
68	synaptic transmission, cholinergic (GO:0007271)	2.52386657
69	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.52264241
70	negative regulation of response to food (GO:0032096)	2.51029322
71	negative regulation of appetite (GO:0032099)	2.51029322
72	hydrogen ion transmembrane transport (GO:1902600)	2.50874246
73	nucleobase catabolic process (GO:0046113)	2.50418384
74	quinone biosynthetic process (GO:1901663)	2.49493399
75	regulation of cellular amino acid metabolic process (GO:0006521)	2.49348472
76	positive regulation of calcium-mediated signaling (GO:0050850)	2.48249131
77	nonmotile primary cilium assembly (GO:0035058)	2.47226748
78	regulation of microtubule-based movement (GO:0060632)	2.46772471
79	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.46416782
80	transmission of nerve impulse (GO:0019226)	2.46159093
81	cell proliferation in forebrain (GO:0021846)	2.45059981
82	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.43317866
83	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.43317866
84	NADH dehydrogenase complex assembly (GO:0010257)	2.43317866
85	DNA dealkylation (GO:0035510)	2.42036669
86	proton transport (GO:0015992)	2.39620669
87	mitochondrion transport along microtubule (GO:0047497)	2.38772781
88	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.38772781
89	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.37968739
90	somite development (GO:0061053)	2.37468948
91	regulation of activation of Janus kinase activity (GO:0010533)	2.35911401
92	GPI anchor biosynthetic process (GO:0006506)	2.35247716
93	hydrogen transport (GO:0006818)	2.34411523
94	negative regulation of heart rate (GO:0010459)	2.34295878
95	epithelial cilium movement (GO:0003351)	2.33985204
96	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.30943488
97	regulation of action potential (GO:0098900)	2.30111519
98	regulation of regulatory T cell differentiation (GO:0045589)	2.29501447
99	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.29207334
100	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.29207334

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.43359627
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.29990749
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.24527957
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.11453289
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.82517158
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.69954100
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.45891003
8	VDR_22108803_ChIP-Seq_LS180_Human	2.44523469
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.38547613
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.28110125
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.20080831
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.18455514
13	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.08975036
14	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.01830410
15	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.93416900
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.90264404
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.86158950
18	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.81078265
19	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.59501912
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.59397814
21	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.58213492
22	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.53408197
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.50379358
24	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.50115800
25	VDR_23849224_ChIP-Seq_CD4+_Human	1.49342877
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.48399633
27	EWS_26573619_Chip-Seq_HEK293_Human	1.47412631
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.47341786
29	REST_21632747_ChIP-Seq_MESCs_Mouse	1.47058123
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.45012819
31	GBX2_23144817_ChIP-Seq_PC3_Human	1.40199871
32	P300_19829295_ChIP-Seq_ESCs_Human	1.39902077
33	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.38895535
34	NANOG_19829295_ChIP-Seq_ESCs_Human	1.33537268
35	SOX2_19829295_ChIP-Seq_ESCs_Human	1.33537268
36	NANOG_20526341_ChIP-Seq_ESCs_Human	1.33417803
37	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.32681111
38	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.32133961
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31985526
40	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.30505002
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.29202169
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.29202169
43	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.28464661
44	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.28127621
45	HTT_18923047_ChIP-ChIP_STHdh_Human	1.27844070
46	RNF2_27304074_Chip-Seq_NSC_Mouse	1.27824920
47	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.27211471
48	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.26968628
49	AR_20517297_ChIP-Seq_VCAP_Human	1.26618591
50	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.26197674
51	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.25786636
52	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.25296283
53	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.24399197
54	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.20385591
55	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.20186586
56	IRF1_19129219_ChIP-ChIP_H3396_Human	1.20009924
57	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.19374637
58	NCOR_22424771_ChIP-Seq_293T_Human	1.18133927
59	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.16518259
60	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.16343777
61	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.15865579
62	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.15779668
63	ERA_21632823_ChIP-Seq_H3396_Human	1.15754426
64	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.15544345
65	ER_23166858_ChIP-Seq_MCF-7_Human	1.14427919
66	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.12364992
67	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.12357961
68	CBP_20019798_ChIP-Seq_JUKART_Human	1.12357961
69	TAF2_19829295_ChIP-Seq_ESCs_Human	1.12065684
70	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.11504177
71	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.11468868
72	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.10259674
73	MYC_19829295_ChIP-Seq_ESCs_Human	1.09060674
74	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.08594116
75	FOXP3_21729870_ChIP-Seq_TREG_Human	1.08092599
76	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.07838458
77	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.07483131
78	BCAT_22108803_ChIP-Seq_LS180_Human	1.07105809
79	TAF15_26573619_Chip-Seq_HEK293_Human	1.04785350
80	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02925149
81	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01835590
82	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.01657277
83	ELK1_19687146_ChIP-ChIP_HELA_Human	1.01572948
84	P53_21459846_ChIP-Seq_SAOS-2_Human	1.01244788
85	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01162216
86	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.00345621
87	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00149288
88	BCL6_27268052_Chip-Seq_Bcells_Human	1.00004110
89	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.00003395
90	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.99570393
91	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.99184518
92	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.98845471
93	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.98147321
94	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.96539183
95	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.96389869
96	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.95790237
97	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.94890710
98	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.94234483
99	CIITA_25753668_ChIP-Seq_RAJI_Human	0.93843961
100	GATA3_26560356_Chip-Seq_TH2_Human	0.92958493

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.21317066
2	MP0003787_abnormal_imprinting	3.79372459
3	MP0005646_abnormal_pituitary_gland	3.09673342
4	MP0008789_abnormal_olfactory_epithelium	3.06374282
5	MP0005671_abnormal_response_to	2.86506706
6	MP0002638_abnormal_pupillary_reflex	2.72151975
7	MP0005499_abnormal_olfactory_system	2.61371493
8	MP0005394_taste/olfaction_phenotype	2.61371493
9	MP0002653_abnormal_ependyma_morphology	2.58034677
10	MP0002822_catalepsy	2.54878218
11	MP0008877_abnormal_DNA_methylation	2.47283409
12	MP0006276_abnormal_autonomic_nervous	2.44845130
13	MP0001485_abnormal_pinna_reflex	2.37127857
14	MP0001529_abnormal_vocalization	2.36615348
15	MP0002102_abnormal_ear_morphology	2.25352314
16	MP0005645_abnormal_hypothalamus_physiol	2.16223539
17	MP0003880_abnormal_central_pattern	1.93161666
18	MP0006072_abnormal_retinal_apoptosis	1.88280233
19	MP0003646_muscle_fatigue	1.82788186
20	MP0004147_increased_porphyrin_level	1.74177785
21	MP0001968_abnormal_touch/_nociception	1.70164745
22	MP0004142_abnormal_muscle_tone	1.67361420
23	MP0001905_abnormal_dopamine_level	1.67028597
24	MP0003121_genomic_imprinting	1.61784096
25	MP0001188_hyperpigmentation	1.61487676
26	MP0005551_abnormal_eye_electrophysiolog	1.59463472
27	MP0010386_abnormal_urinary_bladder	1.54696644
28	MP0002160_abnormal_reproductive_system	1.53560687
29	MP0004885_abnormal_endolymph	1.53352030
30	MP0005084_abnormal_gallbladder_morpholo	1.52961623
31	MP0004742_abnormal_vestibular_system	1.49924031
32	MP0008872_abnormal_physiological_respon	1.42862745
33	MP0005253_abnormal_eye_physiology	1.40227297
34	MP0002736_abnormal_nociception_after	1.38217293
35	MP0005167_abnormal_blood-brain_barrier	1.36163602
36	MP0009745_abnormal_behavioral_response	1.36081352
37	MP0005410_abnormal_fertilization	1.33181249
38	MP0009785_altered_susceptibility_to	1.31962717
39	MP0002272_abnormal_nervous_system	1.31924998
40	MP0009764_decreased_sensitivity_to	1.28481660
41	MP0009046_muscle_twitch	1.28442279
42	MP0005389_reproductive_system_phenotype	1.27702524
43	MP0001984_abnormal_olfaction	1.25689061
44	MP0001835_abnormal_antigen_presentation	1.25044111
45	MP0000372_irregular_coat_pigmentation	1.21981862
46	MP0003011_delayed_dark_adaptation	1.21666930
47	MP0000631_abnormal_neuroendocrine_gland	1.21477972
48	MP0001919_abnormal_reproductive_system	1.21279687
49	MP0002876_abnormal_thyroid_physiology	1.20900058
50	MP0002163_abnormal_gland_morphology	1.17721002
51	MP0002735_abnormal_chemical_nociception	1.17563220
52	MP0001970_abnormal_pain_threshold	1.15542262
53	MP0002148_abnormal_hypersensitivity_rea	1.13486466
54	MP0001986_abnormal_taste_sensitivity	1.12788877
55	MP0002733_abnormal_thermal_nociception	1.11296671
56	MP0005464_abnormal_platelet_physiology	1.08358348
57	MP0000778_abnormal_nervous_system	1.04800721
58	MP0002909_abnormal_adrenal_gland	1.04708019
59	MP0001486_abnormal_startle_reflex	1.04232820
60	MP0003878_abnormal_ear_physiology	1.03416686
61	MP0005377_hearing/vestibular/ear_phenot	1.03416686
62	MP0005423_abnormal_somatic_nervous	1.01158657
63	MP0002557_abnormal_social/conspecific_i	0.97822891
64	MP0002572_abnormal_emotion/affect_behav	0.97009250
65	MP0002138_abnormal_hepatobiliary_system	0.96024149
66	MP0000230_abnormal_systemic_arterial	0.95300617
67	MP0009379_abnormal_foot_pigmentation	0.93974450
68	MP0002277_abnormal_respiratory_mucosa	0.92780556
69	MP0003866_abnormal_defecation	0.90286499
70	MP0005195_abnormal_posterior_eye	0.89426723
71	MP0001963_abnormal_hearing_physiology	0.89332639
72	MP0003122_maternal_imprinting	0.88925588
73	MP0004145_abnormal_muscle_electrophysio	0.87891450
74	MP0003635_abnormal_synaptic_transmissio	0.86871136
75	MP0001800_abnormal_humoral_immune	0.86480965
76	MP0000026_abnormal_inner_ear	0.85440239
77	MP0002752_abnormal_somatic_nervous	0.85260221
78	MP0002067_abnormal_sensory_capabilities	0.83489369
79	MP0005025_abnormal_response_to	0.80936003
80	MP0004924_abnormal_behavior	0.79787425
81	MP0005386_behavior/neurological_phenoty	0.79787425
82	MP0002420_abnormal_adaptive_immunity	0.79620931
83	MP0002723_abnormal_immune_serum	0.78900163
84	MP0003567_abnormal_fetal_cardiomyocyte	0.78214314
85	MP0002938_white_spotting	0.77889031
86	MP0005000_abnormal_immune_tolerance	0.76118800
87	MP0001819_abnormal_immune_cell	0.75986157
88	MP0002064_seizures	0.75677363
89	MP0006036_abnormal_mitochondrial_physio	0.74949733
90	MP0003724_increased_susceptibility_to	0.74712728
91	MP0002063_abnormal_learning/memory/cond	0.74215835
92	MP0008995_early_reproductive_senescence	0.72497956
93	MP0004133_heterotaxia	0.72246458
94	MP0002837_dystrophic_cardiac_calcinosis	0.70080405
95	MP0003763_abnormal_thymus_physiology	0.69935078
96	MP0003137_abnormal_impulse_conducting	0.69283468
97	MP0000049_abnormal_middle_ear	0.69152133
98	MP0002734_abnormal_mechanical_nocicepti	0.68591185
99	MP0003879_abnormal_hair_cell	0.67035068
100	MP0001119_abnormal_female_reproductive	0.66098425

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.77732118
2	Acute necrotizing encephalopathy (HP:0006965)	3.70617270
3	3-Methylglutaconic aciduria (HP:0003535)	3.69973952
4	Elevated erythrocyte sedimentation rate (HP:0003565)	3.59057680
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.42154059
6	Mitochondrial inheritance (HP:0001427)	3.40811916
7	Abolished electroretinogram (ERG) (HP:0000550)	3.39250188
8	Molar tooth sign on MRI (HP:0002419)	3.29004836
9	Abnormality of midbrain morphology (HP:0002418)	3.29004836
10	Acute encephalopathy (HP:0006846)	3.28583857
11	Congenital stationary night blindness (HP:0007642)	3.21184636
12	Pendular nystagmus (HP:0012043)	3.14279417
13	Pancreatic cysts (HP:0001737)	3.06051281
14	Severe combined immunodeficiency (HP:0004430)	3.04562890
15	Progressive macrocephaly (HP:0004481)	3.02173045
16	Aplastic anemia (HP:0001915)	3.01748810
17	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.93017371
18	True hermaphroditism (HP:0010459)	2.92109969
19	Abnormal rod and cone electroretinograms (HP:0008323)	2.91495681
20	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.88691400
21	Hypoplasia of the fovea (HP:0007750)	2.88691400
22	Hypoproteinemia (HP:0003075)	2.83782106
23	Hepatocellular necrosis (HP:0001404)	2.83243656
24	Pancreatic fibrosis (HP:0100732)	2.82419497
25	Increased CSF lactate (HP:0002490)	2.82033219
26	Type II lissencephaly (HP:0007260)	2.74749178
27	Abnormality of the fovea (HP:0000493)	2.72125375
28	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.71817008
29	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.71817008
30	Thyroiditis (HP:0100646)	2.70642703
31	Hepatic necrosis (HP:0002605)	2.67519273
32	Optic disc pallor (HP:0000543)	2.64452392
33	Increased IgM level (HP:0003496)	2.63196638
34	Decreased central vision (HP:0007663)	2.61469792
35	Attenuation of retinal blood vessels (HP:0007843)	2.60643771
36	Increased hepatocellular lipid droplets (HP:0006565)	2.57291025
37	Increased intramyocellular lipid droplets (HP:0012240)	2.56033372
38	Lissencephaly (HP:0001339)	2.54114741
39	Medial flaring of the eyebrow (HP:0010747)	2.48401425
40	Retinal dysplasia (HP:0007973)	2.46912844
41	IgG deficiency (HP:0004315)	2.45278717
42	Renal Fanconi syndrome (HP:0001994)	2.45135814
43	Abnormal respiratory epithelium morphology (HP:0012253)	2.42355770
44	Abnormal respiratory motile cilium morphology (HP:0005938)	2.42355770
45	Lipid accumulation in hepatocytes (HP:0006561)	2.41376056
46	Hyperglycinemia (HP:0002154)	2.39612625
47	Broad-based gait (HP:0002136)	2.32988061
48	Reticulocytopenia (HP:0001896)	2.31583872
49	Cerebral edema (HP:0002181)	2.29971304
50	Optic nerve coloboma (HP:0000588)	2.28423398
51	Renal cortical cysts (HP:0000803)	2.22675829
52	Combined immunodeficiency (HP:0005387)	2.22205136
53	Absent/shortened dynein arms (HP:0200106)	2.18240874
54	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.18240874
55	Optic nerve hypoplasia (HP:0000609)	2.16331192
56	Increased muscle lipid content (HP:0009058)	2.15743663
57	Stomatitis (HP:0010280)	2.15433375
58	Abnormality of the renal cortex (HP:0011035)	2.13503312
59	Agitation (HP:0000713)	2.12807866
60	Gait imbalance (HP:0002141)	2.12369914
61	Abnormality of B cell number (HP:0010975)	2.10486413
62	Panhypogammaglobulinemia (HP:0003139)	2.10252196
63	Generalized aminoaciduria (HP:0002909)	2.07755417
64	Abnormality of the labia minora (HP:0012880)	2.07387664
65	Methylmalonic aciduria (HP:0012120)	2.05259492
66	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.04868365
67	Abnormality of eosinophils (HP:0001879)	2.01097567
68	Congenital primary aphakia (HP:0007707)	2.01076673
69	Myokymia (HP:0002411)	1.99663463
70	Pancytopenia (HP:0001876)	1.99167505
71	T lymphocytopenia (HP:0005403)	1.99054711
72	B lymphocytopenia (HP:0010976)	1.97619495
73	Pachygyria (HP:0001302)	1.94148911
74	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.93524579
75	Dicarboxylic aciduria (HP:0003215)	1.93524579
76	Amyotrophic lateral sclerosis (HP:0007354)	1.93450354
77	Increased serum lactate (HP:0002151)	1.93387678
78	Lactic acidosis (HP:0003128)	1.91405674
79	Constricted visual fields (HP:0001133)	1.89151965
80	Cerebral palsy (HP:0100021)	1.88569693
81	Abnormality of the prostate (HP:0008775)	1.87390794
82	Sclerocornea (HP:0000647)	1.86889289
83	Keratoconus (HP:0000563)	1.85161894
84	Increased corneal curvature (HP:0100692)	1.85161894
85	Abnormality of T cell number (HP:0011839)	1.84013319
86	Nephrogenic diabetes insipidus (HP:0009806)	1.83735360
87	Cerebellar dysplasia (HP:0007033)	1.78820519
88	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.77683639
89	Petechiae (HP:0000967)	1.76032914
90	Nephronophthisis (HP:0000090)	1.73796869
91	Bony spicule pigmentary retinopathy (HP:0007737)	1.71364607
92	Hypomagnesemia (HP:0002917)	1.71235249
93	Exertional dyspnea (HP:0002875)	1.70587895
94	Vaginal atresia (HP:0000148)	1.69680948
95	Aplasia/hypoplasia of the uterus (HP:0008684)	1.69276748
96	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.68624500
97	Male pseudohermaphroditism (HP:0000037)	1.67633371
98	Cystic liver disease (HP:0006706)	1.67172689
99	Adrenal hypoplasia (HP:0000835)	1.67049125
100	Type 2 muscle fiber atrophy (HP:0003554)	1.66712979

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	KDR	3.97605485
2	TESK2	3.89766583
3	TXK	3.20472083
4	WNK3	2.84700844
5	ADRBK2	2.78857804
6	VRK2	2.78603637
7	MAP4K2	2.59952552
8	SIK2	2.59703613
9	ZAK	2.56345861
10	BCKDK	2.28078701
11	GRK1	2.22408715
12	DYRK2	2.18276442
13	CDK19	2.13467225
14	LIMK1	2.10988265
15	FRK	2.09261816
16	MAPK13	2.09126246
17	TAOK3	1.95806422
18	MAP4K1	1.93094734
19	PINK1	1.76903589
20	MAP2K7	1.67032334
21	CASK	1.63743952
22	WNK4	1.62895215
23	VRK1	1.62704319
24	TLK1	1.51282506
25	TESK1	1.45294857
26	STK16	1.38095179
27	TRIM28	1.33513041
28	TIE1	1.32706228
29	MUSK	1.32468868
30	MARK1	1.30229465
31	MAP3K4	1.25718298
32	NUAK1	1.21568586
33	DYRK3	1.16400813
34	MAP3K11	1.12280172
35	TEC	1.08539585
36	ITK	1.08420186
37	CSNK1G3	1.07251935
38	RPS6KA4	1.02104366
39	CSNK1G2	1.01819785
40	SYK	0.98890628
41	INSRR	0.96083928
42	FES	0.95326453
43	BMPR1B	0.89417013
44	NEK2	0.88461207
45	GRK7	0.88385158
46	PRKCQ	0.83764822
47	CSNK1G1	0.83563525
48	BCR	0.82604430
49	MINK1	0.80166211
50	OXSR1	0.79095722
51	STK39	0.77385586
52	CSNK1A1L	0.74958468
53	PTK2B	0.70734775
54	TNK2	0.69149572
55	RPS6KA5	0.68720788
56	CDK8	0.67196732
57	KIT	0.63738644
58	BTK	0.63555648
59	PIK3CG	0.62245870
60	ADRBK1	0.60462929
61	DAPK1	0.60368415
62	GRK5	0.60304839
63	LYN	0.59790735
64	FLT3	0.57540507
65	CSF1R	0.56717814
66	DAPK2	0.55736942
67	SRPK1	0.54835381
68	MATK	0.54485342
69	PRKCG	0.54265648
70	HIPK2	0.54129144
71	MST4	0.49575334
72	LCK	0.48965604
73	PIM2	0.47838444
74	TNIK	0.46080638
75	PRKACA	0.44065385
76	DYRK1B	0.43931747
77	SCYL2	0.43205804
78	EPHA3	0.43180576
79	AURKA	0.41313291
80	BUB1	0.40468231
81	MAP2K6	0.40459423
82	PRKCA	0.38192259
83	IKBKB	0.37901004
84	ERBB3	0.37194820
85	PLK4	0.36643692
86	PKN1	0.35963673
87	PRKCE	0.35933182
88	CSNK1A1	0.35832124
89	OBSCN	0.35331287
90	LRRK2	0.34319328
91	CAMK2A	0.33949074
92	NTRK2	0.33467655
93	CSNK2A1	0.33387913
94	WEE1	0.31939224
95	DYRK1A	0.31494497
96	IRAK4	0.31382751
97	PLK2	0.31050955
98	GRK6	0.30887794
99	MAPKAPK3	0.30156334
100	ROCK1	0.28632085

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.82477407
2	Parkinsons disease_Homo sapiens_hsa05012	3.52469183
3	Primary immunodeficiency_Homo sapiens_hsa05340	3.40622815
4	Proteasome_Homo sapiens_hsa03050	3.33781496
5	Phototransduction_Homo sapiens_hsa04744	2.35522588
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.33738458
7	Ribosome_Homo sapiens_hsa03010	2.27368042
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.25782840
9	RNA polymerase_Homo sapiens_hsa03020	2.16553094
10	Alzheimers disease_Homo sapiens_hsa05010	2.11700812
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.06302778
12	Huntingtons disease_Homo sapiens_hsa05016	2.04778395
13	Cardiac muscle contraction_Homo sapiens_hsa04260	1.89770583
14	Graft-versus-host disease_Homo sapiens_hsa05332	1.84754720
15	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.79809937
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.79542444
17	Protein export_Homo sapiens_hsa03060	1.75918718
18	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.71982127
19	Allograft rejection_Homo sapiens_hsa05330	1.70946445
20	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.62897640
21	Peroxisome_Homo sapiens_hsa04146	1.59960798
22	Nicotine addiction_Homo sapiens_hsa05033	1.59708710
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.59130659
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.57216734
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.44763473
26	Type I diabetes mellitus_Homo sapiens_hsa04940	1.43509170
27	Antigen processing and presentation_Homo sapiens_hsa04612	1.39235419
28	Butanoate metabolism_Homo sapiens_hsa00650	1.39114389
29	Asthma_Homo sapiens_hsa05310	1.28617888
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.27839982
31	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.27149547
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.16366610
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.16037739
34	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.13825774
35	Basal transcription factors_Homo sapiens_hsa03022	1.11254854
36	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.09065467
37	Rheumatoid arthritis_Homo sapiens_hsa05323	1.07457208
38	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.05633125
39	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.05377202
40	Olfactory transduction_Homo sapiens_hsa04740	1.03017533
41	Collecting duct acid secretion_Homo sapiens_hsa04966	1.02724421
42	Steroid biosynthesis_Homo sapiens_hsa00100	1.00575571
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.98766698
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.98307339
45	Pyrimidine metabolism_Homo sapiens_hsa00240	0.97211959
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.95801609
47	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.94000361
48	Morphine addiction_Homo sapiens_hsa05032	0.93433439
49	Homologous recombination_Homo sapiens_hsa03440	0.92977798
50	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.91447484
51	Retinol metabolism_Homo sapiens_hsa00830	0.91084155
52	RNA degradation_Homo sapiens_hsa03018	0.87758359
53	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.87111461
54	Propanoate metabolism_Homo sapiens_hsa00640	0.85460903
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.83193142
56	Regulation of autophagy_Homo sapiens_hsa04140	0.82143343
57	Caffeine metabolism_Homo sapiens_hsa00232	0.79440613
58	Fanconi anemia pathway_Homo sapiens_hsa03460	0.76949418
59	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.76324560
60	Taste transduction_Homo sapiens_hsa04742	0.75412707
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.75188894
62	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.74445963
63	GABAergic synapse_Homo sapiens_hsa04727	0.71652200
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.70879654
65	One carbon pool by folate_Homo sapiens_hsa00670	0.67347121
66	DNA replication_Homo sapiens_hsa03030	0.66985090
67	Mismatch repair_Homo sapiens_hsa03430	0.65469955
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.64417186
69	Purine metabolism_Homo sapiens_hsa00230	0.62949790
70	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.62810883
71	Metabolic pathways_Homo sapiens_hsa01100	0.61796018
72	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.61360590
73	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.61167971
74	Viral myocarditis_Homo sapiens_hsa05416	0.60664258
75	Base excision repair_Homo sapiens_hsa03410	0.60642789
76	Ether lipid metabolism_Homo sapiens_hsa00565	0.59316187
77	Salmonella infection_Homo sapiens_hsa05132	0.55799160
78	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.53233332
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.52060828
80	Tryptophan metabolism_Homo sapiens_hsa00380	0.51976000
81	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.51253130
82	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.50100683
83	Alcoholism_Homo sapiens_hsa05034	0.49500910
84	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.49189539
85	Sulfur metabolism_Homo sapiens_hsa00920	0.46150343
86	Circadian entrainment_Homo sapiens_hsa04713	0.43446270
87	Serotonergic synapse_Homo sapiens_hsa04726	0.43347921
88	Nucleotide excision repair_Homo sapiens_hsa03420	0.42455873
89	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.40065192
90	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.38266007
91	Fatty acid degradation_Homo sapiens_hsa00071	0.37258886
92	Shigellosis_Homo sapiens_hsa05131	0.36381148
93	Fat digestion and absorption_Homo sapiens_hsa04975	0.35361440
94	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.34433704
95	Selenocompound metabolism_Homo sapiens_hsa00450	0.29265896
96	Dopaminergic synapse_Homo sapiens_hsa04728	0.28839874
97	Glutamatergic synapse_Homo sapiens_hsa04724	0.28389659
98	Fatty acid elongation_Homo sapiens_hsa00062	0.28210102
99	Folate biosynthesis_Homo sapiens_hsa00790	0.27784891
100	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.24048350

H3F3AP6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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