ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	8.41577225
2	ribosomal small subunit assembly (GO:0000028)	6.64155078
3	viral transcription (GO:0019083)	6.14794126
4	behavioral response to nicotine (GO:0035095)	6.03654825
5	translational termination (GO:0006415)	5.84497149
6	ncRNA 3-end processing (GO:0043628)	5.51834525
7	neurofilament cytoskeleton organization (GO:0060052)	5.44993597
8	chaperone-mediated protein transport (GO:0072321)	5.16700070
9	translational elongation (GO:0006414)	4.89537191
10	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.72546931
11	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.64785445
12	cotranslational protein targeting to membrane (GO:0006613)	4.61112041
13	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.59005020
14	protein targeting to ER (GO:0045047)	4.56213569
15	cellular protein complex disassembly (GO:0043624)	4.51643716
16	viral life cycle (GO:0019058)	4.49247236
17	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.42034344
18	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.41159983
19	protein localization to endoplasmic reticulum (GO:0070972)	4.37025645
20	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.28732775
21	ATP synthesis coupled proton transport (GO:0015986)	4.28732775
22	protein neddylation (GO:0045116)	4.22444624
23	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.19487050
24	pyrimidine nucleobase catabolic process (GO:0006208)	4.03203754
25	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	4.01851322
26	maturation of SSU-rRNA (GO:0030490)	3.99342709
27	protein complex disassembly (GO:0043241)	3.84160364
28	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.77847433
29	central nervous system myelination (GO:0022010)	3.76381697
30	axon ensheathment in central nervous system (GO:0032291)	3.76381697
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.72378280
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.72378280
33	NADH dehydrogenase complex assembly (GO:0010257)	3.72378280
34	ribosomal large subunit biogenesis (GO:0042273)	3.66878224
35	macromolecular complex disassembly (GO:0032984)	3.60604957
36	cell proliferation in forebrain (GO:0021846)	3.53599622
37	parturition (GO:0007567)	3.50901944
38	glyoxylate metabolic process (GO:0046487)	3.50640116
39	respiratory electron transport chain (GO:0022904)	3.49499228
40	electron transport chain (GO:0022900)	3.48298934
41	cornea development in camera-type eye (GO:0061303)	3.46920543
42	positive regulation of gastrulation (GO:2000543)	3.45272730
43	ribonucleoprotein complex biogenesis (GO:0022613)	3.42846281
44	protein polyglutamylation (GO:0018095)	3.40999127
45	protein complex biogenesis (GO:0070271)	3.36802525
46	translational initiation (GO:0006413)	3.36278374
47	cellular component biogenesis (GO:0044085)	3.34875724
48	nephron epithelium morphogenesis (GO:0072088)	3.32861572
49	nephron tubule morphogenesis (GO:0072078)	3.32861572
50	hypothalamus development (GO:0021854)	3.25874073
51	nucleobase catabolic process (GO:0046113)	3.25516101
52	substrate-independent telencephalic tangential migration (GO:0021826)	3.24668669
53	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.24668669
54	epithelial cilium movement (GO:0003351)	3.21565792
55	transmission of nerve impulse (GO:0019226)	3.15431667
56	water-soluble vitamin biosynthetic process (GO:0042364)	3.10777602
57	negative regulation of appetite (GO:0032099)	3.10122606
58	negative regulation of response to food (GO:0032096)	3.10122606
59	positive regulation of potassium ion transmembrane transport (GO:1901381)	3.07647094
60	protein targeting to membrane (GO:0006612)	3.06872208
61	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	3.01968985
62	protein-cofactor linkage (GO:0018065)	3.00131515
63	synaptic transmission, cholinergic (GO:0007271)	2.96126835
64	opioid receptor signaling pathway (GO:0038003)	2.95020477
65	collecting duct development (GO:0072044)	2.94667624
66	mitochondrial respiratory chain complex assembly (GO:0033108)	2.93085687
67	regulation of G0 to G1 transition (GO:0070316)	2.92372717
68	neuron recognition (GO:0008038)	2.88472504
69	intracellular protein transmembrane import (GO:0044743)	2.83684440
70	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.81851200
71	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.77503582
72	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.76629352
73	neuron fate determination (GO:0048664)	2.75983862
74	positive regulation of T cell apoptotic process (GO:0070234)	2.74558254
75	negative regulation of telomere maintenance (GO:0032205)	2.70977042
76	nonmotile primary cilium assembly (GO:0035058)	2.70866266
77	GTP biosynthetic process (GO:0006183)	2.69367036
78	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.68933185
79	DNA deamination (GO:0045006)	2.68531461
80	regulation of glutamate receptor signaling pathway (GO:1900449)	2.66934012
81	somite development (GO:0061053)	2.66182162
82	protein import into peroxisome matrix (GO:0016558)	2.65685507
83	hydrogen ion transmembrane transport (GO:1902600)	2.63801778
84	mRNA catabolic process (GO:0006402)	2.63283888
85	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.63015436
86	negative regulation of astrocyte differentiation (GO:0048712)	2.61453045
87	membrane repolarization (GO:0086009)	2.61026220
88	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.60394110
89	pattern specification involved in kidney development (GO:0061004)	2.58855184
90	auditory receptor cell differentiation (GO:0042491)	2.57496968
91	retinal ganglion cell axon guidance (GO:0031290)	2.55902846
92	translation (GO:0006412)	2.55640355
93	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.55250018
94	kidney morphogenesis (GO:0060993)	2.55043227
95	axonal fasciculation (GO:0007413)	2.54817683
96	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.53934315
97	regulation of membrane repolarization (GO:0060306)	2.52575355
98	spinal cord association neuron differentiation (GO:0021527)	2.51533178
99	chaperone-mediated protein complex assembly (GO:0051131)	2.50948606
100	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.50928658

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	7.39682300
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.80594589
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.28804331
4	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.50074098
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.42838962
6	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.31905642
7	VDR_22108803_ChIP-Seq_LS180_Human	2.28051511
8	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.27095650
9	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.22795120
10	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.14313026
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.10417558
12	REST_21632747_ChIP-Seq_MESCs_Mouse	2.09513162
13	IRF1_19129219_ChIP-ChIP_H3396_Human	2.02720881
14	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.90570152
15	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.89018510
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.85352331
17	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.84672572
18	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.83061678
19	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.82518971
20	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.73915213
21	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.71669782
22	GBX2_23144817_ChIP-Seq_PC3_Human	1.71482875
23	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.69993956
24	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.69993956
25	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.68886941
26	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.68274901
27	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.67624399
28	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.65993683
29	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.64096670
30	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.62100080
31	IGF1R_20145208_ChIP-Seq_DFB_Human	1.59626437
32	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.56235826
33	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.56121797
34	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.53649901
35	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.50337252
36	RNF2_27304074_Chip-Seq_NSC_Mouse	1.48170696
37	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.46953820
38	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.39468200
39	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.35921367
40	CTCF_27219007_Chip-Seq_Bcells_Human	1.35538115
41	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.34183014
42	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.33742525
43	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.31067730
44	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.30618038
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30264073
46	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.29057832
47	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.29001339
48	TP53_22573176_ChIP-Seq_HFKS_Human	1.28498807
49	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.27760145
50	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.27388630
51	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.23391241
52	NANOG_20526341_ChIP-Seq_ESCs_Human	1.22695203
53	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.17552095
54	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.13016107
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10217550
56	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.09904693
57	NCOR_22424771_ChIP-Seq_293T_Human	1.09622857
58	TAF2_19829295_ChIP-Seq_ESCs_Human	1.08929299
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.08389079
60	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.07496606
61	ERA_21632823_ChIP-Seq_H3396_Human	1.07326085
62	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.07269752
63	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.04920340
64	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.04529116
65	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.02283753
66	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.00564418
67	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.00009485
68	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.98555612
69	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.96575542
70	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.95460514
71	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.92077954
72	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91662871
73	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.91216060
74	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.90869788
75	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.88516158
76	BCL6_27268052_Chip-Seq_Bcells_Human	0.88291837
77	CTCF_20526341_ChIP-Seq_ESCs_Human	0.87460366
78	CBP_20019798_ChIP-Seq_JUKART_Human	0.87347500
79	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.87347500
80	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.87093517
81	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.86523406
82	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.85931084
83	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.85788717
84	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.84542513
85	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.83371968
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.81763713
87	JUN_21703547_ChIP-Seq_K562_Human	0.81296158
88	P300_19829295_ChIP-Seq_ESCs_Human	0.81245163
89	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.80846537
90	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.80134158
91	P53_21459846_ChIP-Seq_SAOS-2_Human	0.80030735
92	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.79893284
93	HTT_18923047_ChIP-ChIP_STHdh_Human	0.79815468
94	MYC_19829295_ChIP-Seq_ESCs_Human	0.79313017
95	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.79240363
96	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.78526757
97	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.78494753
98	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.78132228
99	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.77918162
100	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.77818434

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.66255129
2	MP0009379_abnormal_foot_pigmentation	3.35156707
3	MP0003787_abnormal_imprinting	3.05073337
4	MP0003121_genomic_imprinting	2.95501217
5	MP0002653_abnormal_ependyma_morphology	2.80235972
6	MP0003879_abnormal_hair_cell	2.55729309
7	MP0003122_maternal_imprinting	2.42323697
8	MP0006276_abnormal_autonomic_nervous	2.27860802
9	MP0003123_paternal_imprinting	2.09022413
10	MP0008789_abnormal_olfactory_epithelium	2.03043557
11	MP0000778_abnormal_nervous_system	2.03027947
12	MP0002163_abnormal_gland_morphology	1.98968688
13	MP0008995_early_reproductive_senescence	1.93001395
14	MP0003880_abnormal_central_pattern	1.91509234
15	MP0005499_abnormal_olfactory_system	1.91357234
16	MP0005394_taste/olfaction_phenotype	1.91357234
17	MP0004142_abnormal_muscle_tone	1.83555129
18	MP0002638_abnormal_pupillary_reflex	1.79181637
19	MP0004859_abnormal_synaptic_plasticity	1.67733224
20	MP0003011_delayed_dark_adaptation	1.63826408
21	MP0004510_myositis	1.63590833
22	MP0005551_abnormal_eye_electrophysiolog	1.63575147
23	MP0002272_abnormal_nervous_system	1.62134747
24	MP0003136_yellow_coat_color	1.61700358
25	MP0002102_abnormal_ear_morphology	1.59281613
26	MP0004885_abnormal_endolymph	1.57145630
27	MP0003635_abnormal_synaptic_transmissio	1.55934094
28	MP0001968_abnormal_touch/_nociception	1.55880089
29	MP0001529_abnormal_vocalization	1.53677304
30	MP0005646_abnormal_pituitary_gland	1.52611665
31	MP0005423_abnormal_somatic_nervous	1.51165182
32	MP0000049_abnormal_middle_ear	1.48851220
33	MP0004742_abnormal_vestibular_system	1.45369639
34	MP0003878_abnormal_ear_physiology	1.45133455
35	MP0005377_hearing/vestibular/ear_phenot	1.45133455
36	MP0000955_abnormal_spinal_cord	1.43111830
37	MP0003646_muscle_fatigue	1.42415881
38	MP0002063_abnormal_learning/memory/cond	1.42325702
39	MP0001970_abnormal_pain_threshold	1.42273702
40	MP0009745_abnormal_behavioral_response	1.42124727
41	MP0002876_abnormal_thyroid_physiology	1.41761422
42	MP0002557_abnormal_social/conspecific_i	1.41434097
43	MP0002160_abnormal_reproductive_system	1.41402246
44	MP0000631_abnormal_neuroendocrine_gland	1.40928036
45	MP0008877_abnormal_DNA_methylation	1.40345143
46	MP0006072_abnormal_retinal_apoptosis	1.38277120
47	MP0002938_white_spotting	1.37233393
48	MP0001485_abnormal_pinna_reflex	1.36978926
49	MP0001905_abnormal_dopamine_level	1.36892075
50	MP0002733_abnormal_thermal_nociception	1.36687655
51	MP0004133_heterotaxia	1.36151318
52	MP0004145_abnormal_muscle_electrophysio	1.34625122
53	MP0002067_abnormal_sensory_capabilities	1.33809776
54	MP0002752_abnormal_somatic_nervous	1.33648409
55	MP0002572_abnormal_emotion/affect_behav	1.33635603
56	MP0003938_abnormal_ear_development	1.32396289
57	MP0002736_abnormal_nociception_after	1.30810365
58	MP0005174_abnormal_tail_pigmentation	1.30111307
59	MP0001986_abnormal_taste_sensitivity	1.30050508
60	MP0000026_abnormal_inner_ear	1.28728174
61	MP0005195_abnormal_posterior_eye	1.25177538
62	MP0002184_abnormal_innervation	1.24258110
63	MP0001984_abnormal_olfaction	1.20900545
64	MP0001293_anophthalmia	1.20114262
65	MP0008875_abnormal_xenobiotic_pharmacok	1.18446235
66	MP0002734_abnormal_mechanical_nocicepti	1.18055411
67	MP0001727_abnormal_embryo_implantation	1.14173814
68	MP0002882_abnormal_neuron_morphology	1.11787084
69	MP0009046_muscle_twitch	1.11503590
70	MP0001440_abnormal_grooming_behavior	1.11194295
71	MP0002837_dystrophic_cardiac_calcinosis	1.10185692
72	MP0005389_reproductive_system_phenotype	1.09516001
73	MP0002735_abnormal_chemical_nociception	1.07097967
74	MP0001963_abnormal_hearing_physiology	1.05555708
75	MP0005379_endocrine/exocrine_gland_phen	1.05301961
76	MP0005645_abnormal_hypothalamus_physiol	1.04901592
77	MP0002064_seizures	1.04333493
78	MP0002095_abnormal_skin_pigmentation	1.01920277
79	MP0003755_abnormal_palate_morphology	1.00444686
80	MP0001486_abnormal_startle_reflex	0.97449844
81	MP0009780_abnormal_chondrocyte_physiolo	0.96031935
82	MP0002152_abnormal_brain_morphology	0.94998674
83	MP0002229_neurodegeneration	0.93649521
84	MP0000372_irregular_coat_pigmentation	0.93146020
85	MP0003942_abnormal_urinary_system	0.92256077
86	MP0002234_abnormal_pharynx_morphology	0.90138509
87	MP0001873_stomach_inflammation	0.89368247
88	MP0004130_abnormal_muscle_cell	0.84896936
89	MP0001919_abnormal_reproductive_system	0.83587023
90	MP0008872_abnormal_physiological_respon	0.81752571
91	MP0006082_CNS_inflammation	0.80733376
92	MP0002116_abnormal_craniofacial_bone	0.79621919
93	MP0001286_abnormal_eye_development	0.78980844
94	MP0005075_abnormal_melanosome_morpholog	0.78947545
95	MP0002249_abnormal_larynx_morphology	0.78914990
96	MP0002210_abnormal_sex_determination	0.76598302
97	MP0001663_abnormal_digestive_system	0.76425614
98	MP0004811_abnormal_neuron_physiology	0.72903465
99	MP0001324_abnormal_eye_pigmentation	0.72013937
100	MP0002822_catalepsy	0.71720190

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.63340215
2	Septo-optic dysplasia (HP:0100842)	3.99620986
3	Abnormality of midbrain morphology (HP:0002418)	3.66023762
4	Molar tooth sign on MRI (HP:0002419)	3.66023762
5	Myokymia (HP:0002411)	3.56370368
6	Acute necrotizing encephalopathy (HP:0006965)	3.50055623
7	Asplenia (HP:0001746)	3.30146111
8	Aplasia/Hypoplasia of the spleen (HP:0010451)	3.23317549
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.14278940
10	Abnormality of the renal collecting system (HP:0004742)	3.12518038
11	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.10382779
12	Abnormality of cells of the erythroid lineage (HP:0012130)	3.09316704
13	Acute encephalopathy (HP:0006846)	3.03763553
14	Pancreatic fibrosis (HP:0100732)	3.03005277
15	Volvulus (HP:0002580)	3.01663209
16	Duplicated collecting system (HP:0000081)	2.96757619
17	Optic disc pallor (HP:0000543)	2.96000019
18	Absent thumb (HP:0009777)	2.93148245
19	Pancreatic cysts (HP:0001737)	2.90616697
20	Abnormality of macular pigmentation (HP:0008002)	2.89259392
21	Nephronophthisis (HP:0000090)	2.85604436
22	Abnormality of DNA repair (HP:0003254)	2.83944995
23	Agitation (HP:0000713)	2.81648177
24	Constricted visual fields (HP:0001133)	2.74565373
25	Progressive macrocephaly (HP:0004481)	2.73676650
26	Mitochondrial inheritance (HP:0001427)	2.64339748
27	Polyphagia (HP:0002591)	2.53645803
28	Medial flaring of the eyebrow (HP:0010747)	2.51653672
29	Attenuation of retinal blood vessels (HP:0007843)	2.51307857
30	Abnormality of the labia minora (HP:0012880)	2.50947988
31	Pallor (HP:0000980)	2.47907674
32	Hyperthyroidism (HP:0000836)	2.47655935
33	Abnormality of the renal medulla (HP:0100957)	2.44812460
34	Supernumerary spleens (HP:0009799)	2.43195375
35	Adrenal hypoplasia (HP:0000835)	2.41770653
36	Ectopic kidney (HP:0000086)	2.39691744
37	Macrocytic anemia (HP:0001972)	2.39486370
38	Abolished electroretinogram (ERG) (HP:0000550)	2.39309330
39	Oligodactyly (hands) (HP:0001180)	2.38731780
40	Optic nerve hypoplasia (HP:0000609)	2.37644341
41	Absent septum pellucidum (HP:0001331)	2.36037101
42	Cerebral edema (HP:0002181)	2.35933072
43	Decreased muscle mass (HP:0003199)	2.32734215
44	True hermaphroditism (HP:0010459)	2.30337079
45	Striae distensae (HP:0001065)	2.29825009
46	Metaphyseal cupping (HP:0003021)	2.28669965
47	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.27074652
48	Stenosis of the external auditory canal (HP:0000402)	2.26414961
49	Gait imbalance (HP:0002141)	2.23539632
50	Congenital stationary night blindness (HP:0007642)	2.21843346
51	Thyroid-stimulating hormone excess (HP:0002925)	2.20237169
52	Growth hormone deficiency (HP:0000824)	2.18151098
53	Increased CSF lactate (HP:0002490)	2.15370810
54	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.14383337
55	3-Methylglutaconic aciduria (HP:0003535)	2.13418523
56	Concave nail (HP:0001598)	2.11951969
57	Cystic liver disease (HP:0006706)	2.11649545
58	Oligodontia (HP:0000677)	2.10737125
59	Severe visual impairment (HP:0001141)	2.08776497
60	Rib fusion (HP:0000902)	2.07512850
61	Abnormal respiratory epithelium morphology (HP:0012253)	2.06954851
62	Abnormal respiratory motile cilium morphology (HP:0005938)	2.06954851
63	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.06589508
64	Anomalous pulmonary venous return (HP:0010772)	2.04056651
65	Abnormal number of erythroid precursors (HP:0012131)	2.03426744
66	Polydipsia (HP:0001959)	2.03031474
67	Abnormal drinking behavior (HP:0030082)	2.03031474
68	Abnormality of renal resorption (HP:0011038)	2.02079271
69	Abnormal rod and cone electroretinograms (HP:0008323)	2.00786604
70	Maternal diabetes (HP:0009800)	1.97335531
71	Congenital primary aphakia (HP:0007707)	1.96690328
72	Osteomalacia (HP:0002749)	1.96650429
73	Sclerocornea (HP:0000647)	1.94211652
74	Renal Fanconi syndrome (HP:0001994)	1.90806683
75	Anophthalmia (HP:0000528)	1.90019425
76	Pendular nystagmus (HP:0012043)	1.89416102
77	Type II lissencephaly (HP:0007260)	1.89063490
78	Abnormal biliary tract physiology (HP:0012439)	1.88840156
79	Bile duct proliferation (HP:0001408)	1.88840156
80	Anencephaly (HP:0002323)	1.87451347
81	Lipid accumulation in hepatocytes (HP:0006561)	1.87129528
82	Oligodactyly (HP:0012165)	1.86809301
83	Horseshoe kidney (HP:0000085)	1.86808124
84	Lissencephaly (HP:0001339)	1.85613332
85	Pachygyria (HP:0001302)	1.85574318
86	Hepatocellular necrosis (HP:0001404)	1.85453636
87	Abnormal ciliary motility (HP:0012262)	1.84727942
88	Chromsome breakage (HP:0040012)	1.82935450
89	Round ear (HP:0100830)	1.81578067
90	Hyperglycinemia (HP:0002154)	1.80186678
91	Increased hepatocellular lipid droplets (HP:0006565)	1.79707689
92	Limb dystonia (HP:0002451)	1.79641197
93	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.79151592
94	Absent/shortened dynein arms (HP:0200106)	1.79151592
95	Nephrogenic diabetes insipidus (HP:0009806)	1.76516315
96	Double outlet right ventricle (HP:0001719)	1.74029709
97	Congenital malformation of the right heart (HP:0011723)	1.74029709
98	Vaginal atresia (HP:0000148)	1.73942088
99	Abnormality of the pulmonary veins (HP:0011718)	1.71349305
100	Postaxial foot polydactyly (HP:0001830)	1.70779813

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	6.06855527
2	WNK4	4.41351423
3	STK39	3.21227033
4	BCKDK	2.95173276
5	STK16	2.68183392
6	KIT	2.42074728
7	BMPR1B	2.38536796
8	CDK19	2.36226910
9	TXK	2.35968638
10	TYRO3	2.27109200
11	DYRK2	2.20401741
12	MAP3K4	2.14387914
13	NTRK2	2.11247254
14	ADRBK2	1.86508871
15	WNK3	1.85333874
16	MAP2K7	1.73646323
17	MARK1	1.67102299
18	CASK	1.66425948
19	MAP4K1	1.60077211
20	FES	1.53664776
21	GRK1	1.40719339
22	EPHB2	1.30923380
23	MINK1	1.26171542
24	TEC	1.25061569
25	MAPK13	1.22602754
26	MUSK	1.21566134
27	PRKCG	1.13375517
28	MAP3K9	1.10184573
29	PIK3CA	1.06235834
30	PINK1	1.05682227
31	MAP3K11	1.05640372
32	MAP4K2	1.01501619
33	DYRK3	0.99329804
34	ABL2	0.94846672
35	DYRK1B	0.89354783
36	WNK1	0.88694860
37	ADRBK1	0.87299279
38	ZAK	0.85976592
39	MAP2K4	0.84140258
40	SGK494	0.83589366
41	SGK223	0.83589366
42	PAK3	0.82081482
43	OXSR1	0.77060265
44	PHKG1	0.73984385
45	PHKG2	0.73984385
46	CAMK1D	0.73069488
47	TIE1	0.72700786
48	PRKCQ	0.71860990
49	IKBKB	0.70877786
50	SYK	0.70326895
51	CAMK1	0.70257420
52	CDK8	0.69163531
53	LRRK2	0.68882361
54	LIMK1	0.67316088
55	PRKACA	0.66551050
56	SIK2	0.64391444
57	INSRR	0.59363937
58	PRKCH	0.58387726
59	NTRK3	0.56611180
60	FRK	0.56400284
61	EPHA4	0.55091858
62	CAMK2A	0.54879725
63	DYRK1A	0.53870849
64	CAMKK1	0.53054621
65	RPS6KA6	0.52586448
66	TESK2	0.51450725
67	MAPK12	0.49978223
68	PIM2	0.49645342
69	PRKD3	0.48368695
70	CDC7	0.46475654
71	CAMKK2	0.46158071
72	PKN1	0.44162747
73	CDK14	0.44025992
74	AURKA	0.43986298
75	PLK2	0.43722937
76	CAMK2D	0.43341780
77	SGK1	0.43282429
78	GRK7	0.42545486
79	TLK1	0.42507225
80	CDK5	0.42353935
81	BRAF	0.41868907
82	CSK	0.41790338
83	PRKCA	0.41403081
84	CSNK1A1	0.40268585
85	OBSCN	0.39283522
86	BTK	0.38656676
87	CSNK1E	0.38350325
88	SGK2	0.38063916
89	TNIK	0.37698329
90	PRKCE	0.37580826
91	STK11	0.37423125
92	RPS6KC1	0.37044532
93	RPS6KL1	0.37044532
94	PRKACG	0.35873143
95	RPS6KA2	0.35757728
96	PRKCZ	0.35625456
97	PRKD2	0.35180107
98	INSR	0.34407119
99	CAMK1G	0.33665505
100	LYN	0.32949209

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.25372806
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.58844374
3	Parkinsons disease_Homo sapiens_hsa05012	3.82627571
4	Cardiac muscle contraction_Homo sapiens_hsa04260	3.38093316
5	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.98270246
6	Alzheimers disease_Homo sapiens_hsa05010	2.68151760
7	Huntingtons disease_Homo sapiens_hsa05016	2.57396490
8	Phototransduction_Homo sapiens_hsa04744	2.54387440
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.48050179
10	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.95964442
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.94404982
12	Nicotine addiction_Homo sapiens_hsa05033	1.93137866
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.86520987
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.82011828
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.76787340
16	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.72596305
17	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.68575447
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.48606248
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.45914684
20	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.27387278
21	Peroxisome_Homo sapiens_hsa04146	1.21665990
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.19600584
23	Steroid biosynthesis_Homo sapiens_hsa00100	1.19573411
24	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.17252336
25	Butanoate metabolism_Homo sapiens_hsa00650	1.14989432
26	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.14356910
27	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.11994483
28	Basal cell carcinoma_Homo sapiens_hsa05217	1.09990948
29	Morphine addiction_Homo sapiens_hsa05032	1.07355043
30	Olfactory transduction_Homo sapiens_hsa04740	1.04876602
31	Caffeine metabolism_Homo sapiens_hsa00232	1.03181156
32	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.02449348
33	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.01378038
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.98890511
35	Ether lipid metabolism_Homo sapiens_hsa00565	0.98877450
36	GABAergic synapse_Homo sapiens_hsa04727	0.98422362
37	Serotonergic synapse_Homo sapiens_hsa04726	0.98056172
38	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.98036236
39	Retinol metabolism_Homo sapiens_hsa00830	0.96251484
40	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.96103416
41	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.95497992
42	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.93470550
43	Glutamatergic synapse_Homo sapiens_hsa04724	0.91778407
44	Notch signaling pathway_Homo sapiens_hsa04330	0.90706099
45	beta-Alanine metabolism_Homo sapiens_hsa00410	0.90305013
46	Insulin secretion_Homo sapiens_hsa04911	0.89634022
47	Pyruvate metabolism_Homo sapiens_hsa00620	0.87613986
48	Protein export_Homo sapiens_hsa03060	0.85120807
49	Nitrogen metabolism_Homo sapiens_hsa00910	0.84962294
50	Axon guidance_Homo sapiens_hsa04360	0.82878316
51	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.82316399
52	RNA polymerase_Homo sapiens_hsa03020	0.80398480
53	Basal transcription factors_Homo sapiens_hsa03022	0.79368572
54	Taste transduction_Homo sapiens_hsa04742	0.79186266
55	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.79040363
56	Fanconi anemia pathway_Homo sapiens_hsa03460	0.76957790
57	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.76447623
58	Chemical carcinogenesis_Homo sapiens_hsa05204	0.75816650
59	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.73131510
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.72945762
61	Metabolic pathways_Homo sapiens_hsa01100	0.72753165
62	Fat digestion and absorption_Homo sapiens_hsa04975	0.71905811
63	Arginine and proline metabolism_Homo sapiens_hsa00330	0.70655682
64	Collecting duct acid secretion_Homo sapiens_hsa04966	0.69066337
65	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.64042469
66	Circadian entrainment_Homo sapiens_hsa04713	0.63882200
67	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.61291476
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60565285
69	Cholinergic synapse_Homo sapiens_hsa04725	0.60379244
70	Homologous recombination_Homo sapiens_hsa03440	0.59499072
71	Histidine metabolism_Homo sapiens_hsa00340	0.58321496
72	Sulfur relay system_Homo sapiens_hsa04122	0.57217169
73	Dopaminergic synapse_Homo sapiens_hsa04728	0.57046927
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.54615275
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.53526565
76	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.51640974
77	Alcoholism_Homo sapiens_hsa05034	0.49529320
78	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.48448967
79	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.47117396
80	Tyrosine metabolism_Homo sapiens_hsa00350	0.42641608
81	Long-term depression_Homo sapiens_hsa04730	0.42137755
82	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.41896803
83	Fatty acid degradation_Homo sapiens_hsa00071	0.41435698
84	Propanoate metabolism_Homo sapiens_hsa00640	0.41132709
85	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.40928055
86	Pyrimidine metabolism_Homo sapiens_hsa00240	0.39248614
87	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.36583042
88	RNA degradation_Homo sapiens_hsa03018	0.34889449
89	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.34015493
90	Purine metabolism_Homo sapiens_hsa00230	0.33112224
91	Hippo signaling pathway_Homo sapiens_hsa04390	0.32322275
92	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.28621820
93	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.27952495
94	Mismatch repair_Homo sapiens_hsa03430	0.27613230
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.27573741
96	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.27347215
97	Ras signaling pathway_Homo sapiens_hsa04014	0.26676908
98	Bile secretion_Homo sapiens_hsa04976	0.25869545
99	Calcium signaling pathway_Homo sapiens_hsa04020	0.24440502
100	Cocaine addiction_Homo sapiens_hsa05030	0.23772879

H3F3BP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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