H3F3C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded by this gene is a replication-independent histone that is a member of the histone H3 family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)7.65444411
2cytidine catabolic process (GO:0006216)7.65444411
3cytidine deamination (GO:0009972)7.65444411
4pyrimidine ribonucleoside catabolic process (GO:0046133)6.61722425
5ribosomal small subunit assembly (GO:0000028)4.95032933
6telomere maintenance via semi-conservative replication (GO:0032201)4.71855974
7DNA deamination (GO:0045006)4.60294063
8DNA strand elongation involved in DNA replication (GO:0006271)4.53647843
9DNA strand elongation (GO:0022616)4.32995339
10telomere maintenance via recombination (GO:0000722)4.19742738
11deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.06765461
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.06215464
13DNA replication initiation (GO:0006270)4.04460109
14mitotic recombination (GO:0006312)3.89316402
15nucleotide-excision repair, DNA gap filling (GO:0006297)3.81101655
16positive thymic T cell selection (GO:0045059)3.80174231
17regulation of regulatory T cell differentiation (GO:0045589)3.77727105
18positive T cell selection (GO:0043368)3.74208824
19viral transcription (GO:0019083)3.74065824
20translational termination (GO:0006415)3.66395290
21negative regulation by host of viral transcription (GO:0043922)3.64391720
22DNA unwinding involved in DNA replication (GO:0006268)3.62698953
23pyrimidine nucleoside catabolic process (GO:0046135)3.59594171
24telomere maintenance via telomere lengthening (GO:0010833)3.51709720
25actin nucleation (GO:0045010)3.48783788
26tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.47047785
27RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.47047785
28positive regulation of defense response to virus by host (GO:0002230)3.42896429
29formation of translation preinitiation complex (GO:0001731)3.38305091
30negative T cell selection (GO:0043383)3.38300928
31translational elongation (GO:0006414)3.38187800
32maturation of SSU-rRNA (GO:0030490)3.37587783
33cellular response to interleukin-15 (GO:0071350)3.30002947
34positive regulation of calcium-mediated signaling (GO:0050850)3.25291731
35negative regulation of T cell apoptotic process (GO:0070233)3.25020607
36regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.24922314
37SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.22905314
38iron-sulfur cluster assembly (GO:0016226)3.21078745
39metallo-sulfur cluster assembly (GO:0031163)3.21078745
40positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.20484129
41DNA replication checkpoint (GO:0000076)3.19277621
42behavioral response to nicotine (GO:0035095)3.19216710
43mannosylation (GO:0097502)3.15523544
44positive regulation of interleukin-8 secretion (GO:2000484)3.14552397
45Arp2/3 complex-mediated actin nucleation (GO:0034314)3.13399000
46mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.12468019
47positive regulation of T cell mediated cytotoxicity (GO:0001916)3.11519334
48regulation of chronic inflammatory response (GO:0002676)3.11011108
49cotranslational protein targeting to membrane (GO:0006613)3.10267387
50mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.09928809
51protein targeting to ER (GO:0045047)3.09181186
52positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.09091134
53nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.09019845
54positive regulation of natural killer cell mediated immunity (GO:0002717)3.07594650
55positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.05043712
56platelet dense granule organization (GO:0060155)3.04753604
57regulation of activation of Janus kinase activity (GO:0010533)3.00500556
58DNA demethylation (GO:0080111)2.99970766
59negative regulation of viral genome replication (GO:0045071)2.98902989
60translational initiation (GO:0006413)2.96140497
61ATP synthesis coupled proton transport (GO:0015986)2.95504813
62energy coupled proton transport, down electrochemical gradient (GO:0015985)2.95504813
63response to interferon-beta (GO:0035456)2.94976895
64protein localization to endoplasmic reticulum (GO:0070972)2.93774172
65regulation of leukocyte mediated cytotoxicity (GO:0001910)2.93363998
66protein complex biogenesis (GO:0070271)2.92536307
67regulation of cellular amino acid metabolic process (GO:0006521)2.92003938
68regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.91534553
69establishment of integrated proviral latency (GO:0075713)2.91158910
70establishment of protein localization to endoplasmic reticulum (GO:0072599)2.89253596
71eosinophil chemotaxis (GO:0048245)2.88293362
72positive regulation of prostaglandin secretion (GO:0032308)2.87669937
73viral life cycle (GO:0019058)2.87631924
74positive regulation of cell killing (GO:0031343)2.87541010
75ribosomal small subunit biogenesis (GO:0042274)2.85614865
76somatic diversification of immune receptors via somatic mutation (GO:0002566)2.85234567
77somatic hypermutation of immunoglobulin genes (GO:0016446)2.85234567
78positive regulation of gamma-delta T cell activation (GO:0046645)2.85152651
79regulation of T cell mediated cytotoxicity (GO:0001914)2.84260384
80cellular protein complex disassembly (GO:0043624)2.83748117
81telomere maintenance (GO:0000723)2.83292327
82telomere organization (GO:0032200)2.82409395
83preassembly of GPI anchor in ER membrane (GO:0016254)2.81010052
84electron transport chain (GO:0022900)2.80471221
85viral mRNA export from host cell nucleus (GO:0046784)2.80007566
86respiratory electron transport chain (GO:0022904)2.79666669
87CENP-A containing nucleosome assembly (GO:0034080)2.79007367
88response to pheromone (GO:0019236)2.78998896
89T cell migration (GO:0072678)2.78831177
90ribosomal large subunit biogenesis (GO:0042273)2.78643369
91water-soluble vitamin biosynthetic process (GO:0042364)2.77493736
92DNA replication-independent nucleosome assembly (GO:0006336)2.77069647
93DNA replication-independent nucleosome organization (GO:0034724)2.77069647
94regulation of T cell receptor signaling pathway (GO:0050856)2.76909276
95sequestering of actin monomers (GO:0042989)2.76652360
96piRNA metabolic process (GO:0034587)2.76298270
97regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.76224830
98negative regulation of lymphocyte apoptotic process (GO:0070229)2.76194666
99regulation of interleukin-8 secretion (GO:2000482)2.75980029
100positive regulation of B cell differentiation (GO:0045579)2.75303647
101cytolysis (GO:0019835)2.74863008
102GPI anchor metabolic process (GO:0006505)2.74817194
103protein neddylation (GO:0045116)2.73772260
104adaptation of signaling pathway (GO:0023058)2.73174722
105DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.72869584
106negative regulation of RNA splicing (GO:0033119)2.71805994
107negative thymic T cell selection (GO:0045060)2.71075589
108regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.70833402
109regulation of natural killer cell mediated immunity (GO:0002715)2.70833402
110regulation of cell killing (GO:0031341)2.70605117
111translesion synthesis (GO:0019985)2.68349409
112regulation of B cell differentiation (GO:0045577)2.68199003
113protein complex disassembly (GO:0043241)2.67632184
114positive regulation of alpha-beta T cell proliferation (GO:0046641)2.67552881
115pyrimidine-containing compound catabolic process (GO:0072529)2.66653892
116tryptophan catabolic process (GO:0006569)2.66138835
117indole-containing compound catabolic process (GO:0042436)2.66138835
118indolalkylamine catabolic process (GO:0046218)2.66138835
119GPI anchor biosynthetic process (GO:0006506)2.65400018
120chromatin remodeling at centromere (GO:0031055)2.65227938
121negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.64428673
122transcription-coupled nucleotide-excision repair (GO:0006283)2.64172899
123regulation of B cell receptor signaling pathway (GO:0050855)2.63476496
124eosinophil migration (GO:0072677)2.62723826
125ribonucleoprotein complex biogenesis (GO:0022613)2.62530754
126signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.62441075
127signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.62441075
128signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.62441075
129cytochrome complex assembly (GO:0017004)2.62190492
130mitochondrial respiratory chain complex assembly (GO:0033108)2.61170670
131negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.60701924
132negative regulation of phagocytosis (GO:0050765)2.60541288
133nuclear-transcribed mRNA catabolic process (GO:0000956)2.60460851
134DNA dealkylation (GO:0035510)2.60214660
135intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.60124502
136signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.60124502
137indolalkylamine metabolic process (GO:0006586)2.59152908
138definitive hemopoiesis (GO:0060216)2.58942360
139mast cell activation (GO:0045576)2.56921746
140mast cell degranulation (GO:0043303)2.56491402
141mast cell activation involved in immune response (GO:0002279)2.56491402
142thymic T cell selection (GO:0045061)2.55835142
143macromolecular complex disassembly (GO:0032984)2.55286824
144tRNA methylation (GO:0030488)2.54711240
145regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.54279844
146exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.53939180
147kynurenine metabolic process (GO:0070189)2.53119041
148adenosine metabolic process (GO:0046085)2.53101638
149immunoglobulin mediated immune response (GO:0016064)2.53063787
150protein localization to kinetochore (GO:0034501)2.52759862
151mRNA catabolic process (GO:0006402)2.51992136
152somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.51506079
153isotype switching (GO:0045190)2.51506079
154somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.51506079
155dosage compensation (GO:0007549)2.51047431
156respiratory chain complex IV assembly (GO:0008535)2.50653143
157ribosome biogenesis (GO:0042254)2.49962247
158postreplication repair (GO:0006301)2.49489109
159somatic diversification of immune receptors (GO:0002200)2.48287730
160cellular response to zinc ion (GO:0071294)2.48174770
161somatic cell DNA recombination (GO:0016444)2.46947170
162somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.46947170
163DNA ligation (GO:0006266)2.46877083
164regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.45917856
165pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.45021504
166establishment of viral latency (GO:0019043)2.44853128
167RNA catabolic process (GO:0006401)2.44230000
168histone mRNA metabolic process (GO:0008334)2.43385694
169proteasome assembly (GO:0043248)2.43299075
170pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.42857254
171termination of RNA polymerase II transcription (GO:0006369)2.42328366
172somatic diversification of immunoglobulins (GO:0016445)2.42279496
173protein localization to chromosome, centromeric region (GO:0071459)2.42068207
174anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.42009760
175G1/S transition of mitotic cell cycle (GO:0000082)2.41652868
176cell cycle G1/S phase transition (GO:0044843)2.41652868
177base-excision repair (GO:0006284)2.40802538
178translation (GO:0006412)2.40608950
179B cell receptor signaling pathway (GO:0050853)2.40501886
180antigen processing and presentation via MHC class Ib (GO:0002475)2.40328524
181somatic recombination of immunoglobulin gene segments (GO:0016447)2.39514116
182DNA synthesis involved in DNA repair (GO:0000731)2.39506325
183maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.39075682
184antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.38134556
185T cell homeostasis (GO:0043029)2.37090139
186intra-S DNA damage checkpoint (GO:0031573)2.36967719
187regulation of double-strand break repair via homologous recombination (GO:0010569)2.36937307

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.81661758
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.41088496
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.25232123
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.11655405
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.88484254
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.81632455
7ZNF274_21170338_ChIP-Seq_K562_Hela2.74871391
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.74786323
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.71314050
10SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.68682902
11VDR_22108803_ChIP-Seq_LS180_Human2.63274073
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.61456858
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.60167008
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.54643132
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.51772206
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.51505959
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.49283980
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.47504787
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.45514658
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.44655888
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.40109465
22MYC_22102868_ChIP-Seq_BL_Human2.39991557
23VDR_23849224_ChIP-Seq_CD4+_Human2.28506582
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.22738543
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.21649131
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.20572627
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.19200770
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.15794299
29ETS1_20019798_ChIP-Seq_JURKAT_Human2.11243488
30FOXP3_21729870_ChIP-Seq_TREG_Human2.05067658
31HOXB4_20404135_ChIP-ChIP_EML_Mouse2.04213091
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.01384291
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.99990116
34SCL_19346495_ChIP-Seq_HPC-7_Human1.98188373
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97554832
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.97143093
37XRN2_22483619_ChIP-Seq_HELA_Human1.95277016
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91980143
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.91826415
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.90723967
41ERG_20887958_ChIP-Seq_HPC-7_Mouse1.88866809
42SPI1_23547873_ChIP-Seq_NB4_Human1.87114074
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.87045798
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83368294
45ELK1_19687146_ChIP-ChIP_HELA_Human1.83307703
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82903673
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.82350781
48VDR_21846776_ChIP-Seq_THP-1_Human1.76470124
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.75000087
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.74025281
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73316320
52IGF1R_20145208_ChIP-Seq_DFB_Human1.73177989
53DCP1A_22483619_ChIP-Seq_HELA_Human1.72007344
54GATA3_26560356_Chip-Seq_TH2_Human1.68354333
55GABP_19822575_ChIP-Seq_HepG2_Human1.67592276
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65924987
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65847796
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.64783494
59FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.64596320
60MYB_26560356_Chip-Seq_TH2_Human1.63596954
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61034138
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59606532
63STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59216177
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57916263
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.57400631
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55049772
67TTF2_22483619_ChIP-Seq_HELA_Human1.52298855
68TP53_22573176_ChIP-Seq_HFKS_Human1.51617287
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50672914
70CIITA_25753668_ChIP-Seq_RAJI_Human1.49310486
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48300420
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.45906569
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.45472646
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.43300908
75MAF_26560356_Chip-Seq_TH1_Human1.43138839
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.42194443
77MYB_26560356_Chip-Seq_TH1_Human1.41931578
78AR_20517297_ChIP-Seq_VCAP_Human1.40074563
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39125113
80GATA3_27048872_Chip-Seq_THYMUS_Human1.39074282
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.38237856
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.38237856
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.37930364
84MYC_18940864_ChIP-ChIP_HL60_Human1.37567246
85AR_21909140_ChIP-Seq_LNCAP_Human1.37144953
86EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.33807598
87UTX_26944678_Chip-Seq_JUKART_Human1.33016898
88ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31895868
89MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30577348
90RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.30078862
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27756953
92VDR_24763502_ChIP-Seq_THP-1_Human1.27091424
93GATA3_21878914_ChIP-Seq_MCF-7_Human1.26037650
94PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.26010777
95NCOR_22424771_ChIP-Seq_293T_Human1.25992598
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25799698
97THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25694671
98NANOG_20526341_ChIP-Seq_ESCs_Human1.25574610
99TAF2_19829295_ChIP-Seq_ESCs_Human1.25387572
100ER_23166858_ChIP-Seq_MCF-7_Human1.23986735
101PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22593990
102AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22451974
103HTT_18923047_ChIP-ChIP_STHdh_Human1.22182260
104* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.19854853
105EZH2_22144423_ChIP-Seq_EOC_Human1.19089011
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18334046
107RUNX1_22412390_ChIP-Seq_EML_Mouse1.17843270
108SOX2_19829295_ChIP-Seq_ESCs_Human1.16873547
109NANOG_19829295_ChIP-Seq_ESCs_Human1.16873547
110POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15922106
111TFEB_21752829_ChIP-Seq_HELA_Human1.15749281
112KDM5A_27292631_Chip-Seq_BREAST_Human1.15490285
113EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15399432
114STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15070140
115CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14594545
116FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13301771
117YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12947384
118CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12893795
119GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11049080
120ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10444480
121FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10404087
122EWS_26573619_Chip-Seq_HEK293_Human1.09972164
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09912709
124IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09905030
125MYC_19829295_ChIP-Seq_ESCs_Human1.09724579
126E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09304908
127CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08358539
128NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08078019
129MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07019019
130CBP_20019798_ChIP-Seq_JUKART_Human1.05409134
131IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05409134
132CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04526529
133NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03777956
134* BCL6_27268052_Chip-Seq_Bcells_Human1.03568038
135BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03537692
136GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03281843
137NFE2_27457419_Chip-Seq_LIVER_Mouse1.03122981
138BP1_19119308_ChIP-ChIP_Hs578T_Human1.03097696
139ERA_21632823_ChIP-Seq_H3396_Human1.02823334
140ERG_20517297_ChIP-Seq_VCAP_Human1.02459599
141MAF_26560356_Chip-Seq_TH2_Human1.00992193
142RUNX_20019798_ChIP-Seq_JUKART_Human1.00565495
143ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00385805
144IRF1_19129219_ChIP-ChIP_H3396_Human1.00021886
145HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99657280
146POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99470055
147PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99071044
148GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98513466
149SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98069908
150ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97628786
151GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96944866
152* FOXH1_21741376_ChIP-Seq_EPCs_Human0.96712931
153TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96644133
154LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95891413
155EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95585927
156* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95206990
157CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95068777
158IRF8_27001747_Chip-Seq_BMDM_Mouse0.94782772
159TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94387701
160* P300_27268052_Chip-Seq_Bcells_Human0.94214039
161CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93966784
162YY1_21170310_ChIP-Seq_MESCs_Mouse0.93802987
163YY1_22570637_ChIP-Seq_MALME-3M_Human0.92576977
164GATA3_26560356_Chip-Seq_TH1_Human0.92333661
165BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91881754
166* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.91466574

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.54580989
2MP0001835_abnormal_antigen_presentation3.48697066
3MP0002396_abnormal_hematopoietic_system3.29680883
4MP0010094_abnormal_chromosome_stability2.91026527
5MP0003763_abnormal_thymus_physiology2.78647408
6MP0005671_abnormal_response_to2.69604426
7MP0000685_abnormal_immune_system2.68580854
8MP0003077_abnormal_cell_cycle2.52109215
9MP0004808_abnormal_hematopoietic_stem2.44894717
10MP0001800_abnormal_humoral_immune2.36030446
11MP0002398_abnormal_bone_marrow2.34260862
12MP0004957_abnormal_blastocyst_morpholog2.31248994
13MP0008058_abnormal_DNA_repair2.28628275
14MP0003111_abnormal_nucleus_morphology2.23849511
15MP0002102_abnormal_ear_morphology2.23120385
16MP0005174_abnormal_tail_pigmentation2.17660511
17MP0000490_abnormal_crypts_of2.13708472
18MP0002452_abnormal_antigen_presenting2.12833587
19MP0009785_altered_susceptibility_to2.09156887
20MP0002420_abnormal_adaptive_immunity2.05207530
21MP0001790_abnormal_immune_system2.04001202
22MP0005387_immune_system_phenotype2.04001202
23MP0009333_abnormal_splenocyte_physiolog2.03509112
24MP0006072_abnormal_retinal_apoptosis2.02325132
25MP0001819_abnormal_immune_cell2.02263645
26MP0000689_abnormal_spleen_morphology1.98973933
27MP0005075_abnormal_melanosome_morpholog1.94675031
28MP0002723_abnormal_immune_serum1.93130974
29MP0000716_abnormal_immune_system1.92217084
30MP0005000_abnormal_immune_tolerance1.90942207
31MP0002722_abnormal_immune_system1.90456265
32MP0005646_abnormal_pituitary_gland1.89989796
33MP0008057_abnormal_DNA_replication1.88469728
34MP0008007_abnormal_cellular_replicative1.88119556
35MP0002138_abnormal_hepatobiliary_system1.86514661
36MP0010352_gastrointestinal_tract_polyps1.86380178
37MP0008875_abnormal_xenobiotic_pharmacok1.83239840
38MP0008872_abnormal_physiological_respon1.81509109
39MP0002429_abnormal_blood_cell1.80913521
40MP0005025_abnormal_response_to1.80190679
41MP0005645_abnormal_hypothalamus_physiol1.79441371
42MP0001968_abnormal_touch/_nociception1.79313655
43MP0001545_abnormal_hematopoietic_system1.79011506
44MP0005397_hematopoietic_system_phenotyp1.79011506
45MP0002166_altered_tumor_susceptibility1.73550819
46MP0002837_dystrophic_cardiac_calcinosis1.72156323
47MP0000465_gastrointestinal_hemorrhage1.71808910
48MP0003646_muscle_fatigue1.70984205
49MP0000372_irregular_coat_pigmentation1.68899990
50MP0000703_abnormal_thymus_morphology1.68214924
51MP0002405_respiratory_system_inflammati1.64220230
52MP0002132_abnormal_respiratory_system1.62914684
53MP0000015_abnormal_ear_pigmentation1.59146197
54MP0002876_abnormal_thyroid_physiology1.56585349
55MP0003195_calcinosis1.55438066
56MP0002095_abnormal_skin_pigmentation1.53092988
57MP0002736_abnormal_nociception_after1.52648191
58MP0005551_abnormal_eye_electrophysiolog1.52278640
59MP0002019_abnormal_tumor_incidence1.51280680
60MP0006082_CNS_inflammation1.50928340
61MP0010155_abnormal_intestine_physiology1.49121537
62MP0001873_stomach_inflammation1.48131882
63MP0002419_abnormal_innate_immunity1.46449580
64MP0002148_abnormal_hypersensitivity_rea1.44949787
65MP0003436_decreased_susceptibility_to1.43616760
66MP0005410_abnormal_fertilization1.41340739
67MP0002638_abnormal_pupillary_reflex1.39159514
68MP0005464_abnormal_platelet_physiology1.38956180
69MP0002006_tumorigenesis1.38669772
70MP0003011_delayed_dark_adaptation1.33279121
71MP0003303_peritoneal_inflammation1.33251707
72MP0000858_altered_metastatic_potential1.30994227
73MP0001986_abnormal_taste_sensitivity1.30188708
74MP0009764_decreased_sensitivity_to1.28633230
75MP0001905_abnormal_dopamine_level1.27142796
76MP0003724_increased_susceptibility_to1.26939312
77MP0008932_abnormal_embryonic_tissue1.25788931
78MP0005253_abnormal_eye_physiology1.25758689
79MP0009278_abnormal_bone_marrow1.24742172
80MP0006292_abnormal_olfactory_placode1.24537681
81MP0005084_abnormal_gallbladder_morpholo1.24193335
82MP0001853_heart_inflammation1.23841526
83MP0000350_abnormal_cell_proliferation1.22127085
84MP0003123_paternal_imprinting1.21439526
85MP0000313_abnormal_cell_death1.20390953
86MP0003866_abnormal_defecation1.18653936
87MP0003315_abnormal_perineum_morphology1.15744209
88MP0008995_early_reproductive_senescence1.15660631
89MP0001845_abnormal_inflammatory_respons1.15547365
90MP0003943_abnormal_hepatobiliary_system1.15278440
91MP0004885_abnormal_endolymph1.14248990
92MP0006054_spinal_hemorrhage1.13830673
93MP0010307_abnormal_tumor_latency1.13203283
94MP0003806_abnormal_nucleotide_metabolis1.12550995
95MP0010386_abnormal_urinary_bladder1.08878398
96MP0004147_increased_porphyrin_level1.06603807
97MP0001501_abnormal_sleep_pattern1.05193620
98MP0001764_abnormal_homeostasis1.02198307
99MP0009745_abnormal_behavioral_response1.02099661
100MP0002277_abnormal_respiratory_mucosa1.01181240
101MP0003787_abnormal_imprinting1.00946333
102MP0006036_abnormal_mitochondrial_physio1.00465981
103MP0003567_abnormal_fetal_cardiomyocyte1.00396879
104MP0002693_abnormal_pancreas_physiology0.97689427
105MP0003786_premature_aging0.97156972
106MP0004043_abnormal_pH_regulation0.97089704
107MP0002163_abnormal_gland_morphology0.96721071
108MP0004145_abnormal_muscle_electrophysio0.96293892
109MP0006276_abnormal_autonomic_nervous0.95936107
110MP0004142_abnormal_muscle_tone0.94665171
111MP0008877_abnormal_DNA_methylation0.94254977
112MP0005377_hearing/vestibular/ear_phenot0.92400041
113MP0003878_abnormal_ear_physiology0.92400041
114MP0001879_abnormal_lymphatic_vessel0.90593698
115MP0002160_abnormal_reproductive_system0.89123173
116MP0001730_embryonic_growth_arrest0.88726674
117MP0002933_joint_inflammation0.87650230
118MP0005636_abnormal_mineral_homeostasis0.87649234
119MP0008789_abnormal_olfactory_epithelium0.86898288
120MP0000477_abnormal_intestine_morphology0.84843071
121MP0005085_abnormal_gallbladder_physiolo0.84233921
122MP0009697_abnormal_copulation0.83475295
123MP0001984_abnormal_olfaction0.82727161
124MP0000569_abnormal_digit_pigmentation0.82672047
125MP0004947_skin_inflammation0.80831938
126MP0001542_abnormal_bone_strength0.80823552
127MP0001293_anophthalmia0.80803028
128MP0001119_abnormal_female_reproductive0.80368639
129MP0001919_abnormal_reproductive_system0.79674075
130MP0002733_abnormal_thermal_nociception0.78960775
131MP0003121_genomic_imprinting0.78104709
132MP0000516_abnormal_urinary_system0.78077247
133MP0005367_renal/urinary_system_phenotyp0.78077247
134MP0001765_abnormal_ion_homeostasis0.77537799
135MP0003252_abnormal_bile_duct0.77441405
136MP0004742_abnormal_vestibular_system0.77329583
137MP0002080_prenatal_lethality0.76838800
138MP0003137_abnormal_impulse_conducting0.76388925
139MP0005083_abnormal_biliary_tract0.76342212
140MP0009763_increased_sensitivity_to0.76113220
141MP0002272_abnormal_nervous_system0.75915599
142MP0003448_altered_tumor_morphology0.74734041
143MP0005389_reproductive_system_phenotype0.74156208
144MP0003186_abnormal_redox_activity0.74089041
145MP0005670_abnormal_white_adipose0.73024432
146MP0001697_abnormal_embryo_size0.71761182
147MP0003828_pulmonary_edema0.67982462
148MP0000371_diluted_coat_color0.67710859
149MP0008469_abnormal_protein_level0.67405897
150MP0002075_abnormal_coat/hair_pigmentati0.66038658
151MP0002210_abnormal_sex_determination0.65348810
152MP0005310_abnormal_salivary_gland0.65143529
153MP0002086_abnormal_extraembryonic_tissu0.61473635
154MP0002938_white_spotting0.60780903
155MP0003656_abnormal_erythrocyte_physiolo0.59841710
156MP0001186_pigmentation_phenotype0.58867690

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)4.21347353
2Abnormality of cells of the erythroid lineage (HP:0012130)3.78585862
3Abnormal number of erythroid precursors (HP:0012131)3.66838549
4Aplastic anemia (HP:0001915)3.58736796
5Mitochondrial inheritance (HP:0001427)3.57603600
6Reticulocytopenia (HP:0001896)3.57384321
7Birth length less than 3rd percentile (HP:0003561)3.50312621
8Recurrent bronchitis (HP:0002837)3.48650741
9Hypoproteinemia (HP:0003075)3.48401981
10Recurrent abscess formation (HP:0002722)3.39723194
11Acute necrotizing encephalopathy (HP:0006965)3.37286868
12Congenital stationary night blindness (HP:0007642)3.34537389
133-Methylglutaconic aciduria (HP:0003535)3.27203756
14Autoimmune hemolytic anemia (HP:0001890)3.24150373
15Agammaglobulinemia (HP:0004432)3.22289525
16Stomatitis (HP:0010280)3.18420718
17Abnormal mitochondria in muscle tissue (HP:0008316)3.17646067
18Thrombocytosis (HP:0001894)3.15872490
19Colon cancer (HP:0003003)3.13998786
20Pancreatic cysts (HP:0001737)3.13379396
21Increased CSF lactate (HP:0002490)3.09003754
22Elevated erythrocyte sedimentation rate (HP:0003565)3.08941011
23Abnormality of B cell number (HP:0010975)3.05760790
24B lymphocytopenia (HP:0010976)3.05760790
25IgG deficiency (HP:0004315)3.05720887
26Increased intramyocellular lipid droplets (HP:0012240)3.00291530
27Petechiae (HP:0000967)3.00094294
28Hepatocellular necrosis (HP:0001404)2.98863027
29Myositis (HP:0100614)2.98470677
30Type I transferrin isoform profile (HP:0003642)2.95960172
31Progressive macrocephaly (HP:0004481)2.87505235
32Decreased electroretinogram (ERG) amplitude (HP:0000654)2.86138316
33Degeneration of anterior horn cells (HP:0002398)2.84542030
34Abnormality of the anterior horn cell (HP:0006802)2.84542030
35Cellulitis (HP:0100658)2.83688866
36Abnormality of the prostate (HP:0008775)2.83141202
37Hepatic necrosis (HP:0002605)2.79149809
38Acute encephalopathy (HP:0006846)2.78854968
39Increased IgM level (HP:0003496)2.75337482
40Decreased activity of mitochondrial respiratory chain (HP:0008972)2.72902949
41Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.72902949
42Attenuation of retinal blood vessels (HP:0007843)2.72702617
43Abnormality of eosinophils (HP:0001879)2.71578472
44Prolonged bleeding time (HP:0003010)2.71553722
45Thyroiditis (HP:0100646)2.71302974
46Lymphoma (HP:0002665)2.68329261
47Lymphopenia (HP:0001888)2.68246035
48Increased hepatocellular lipid droplets (HP:0006565)2.66346784
49Meningitis (HP:0001287)2.65686959
50Lipid accumulation in hepatocytes (HP:0006561)2.65581630
51Increased muscle lipid content (HP:0009058)2.65079727
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.64221099
53Chronic otitis media (HP:0000389)2.63410713
54Abolished electroretinogram (ERG) (HP:0000550)2.60365169
55Abnormality of the renal cortex (HP:0011035)2.57797150
56Recurrent viral infections (HP:0004429)2.57417412
57Optic nerve coloboma (HP:0000588)2.56121262
58Molar tooth sign on MRI (HP:0002419)2.49478242
59Abnormality of midbrain morphology (HP:0002418)2.49478242
60Abnormal rod and cone electroretinograms (HP:0008323)2.49363687
61Abnormality of the columella (HP:0009929)2.48380792
62Aplasia/Hypoplasia of the sacrum (HP:0008517)2.47335560
63Severe combined immunodeficiency (HP:0004430)2.47217081
64Patellar aplasia (HP:0006443)2.44236168
65Methylmalonic acidemia (HP:0002912)2.42839825
66True hermaphroditism (HP:0010459)2.39124550
67Pancreatic fibrosis (HP:0100732)2.38104108
68Renal Fanconi syndrome (HP:0001994)2.36121594
69Recurrent fungal infections (HP:0002841)2.36092657
70Abnormality of T cells (HP:0002843)2.35308251
71Panhypogammaglobulinemia (HP:0003139)2.34405806
72Pallor (HP:0000980)2.34064835
73Cerebral edema (HP:0002181)2.33667102
74Myelodysplasia (HP:0002863)2.32413104
75T lymphocytopenia (HP:0005403)2.32369570
76Decreased central vision (HP:0007663)2.32112100
77Recurrent pneumonia (HP:0006532)2.31646354
78Increased serum lactate (HP:0002151)2.31604572
79Renal cortical cysts (HP:0000803)2.29801305
80Methylmalonic aciduria (HP:0012120)2.29174496
81Eosinophilia (HP:0001880)2.29135247
82Recurrent bacterial skin infections (HP:0005406)2.28906103
83Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.28433348
84Abnormality of alanine metabolism (HP:0010916)2.28433348
85Hyperalaninemia (HP:0003348)2.28433348
86Aplasia/Hypoplasia of the patella (HP:0006498)2.28226739
87Absent rod-and cone-mediated responses on ERG (HP:0007688)2.27016474
88Recurrent sinusitis (HP:0011108)2.26682792
89Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.24603004
90Optic disc pallor (HP:0000543)2.23686867
91Encephalitis (HP:0002383)2.23669288
92Pancytopenia (HP:0001876)2.23282311
93Poikiloderma (HP:0001029)2.23278029
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.22766058
95Abnormal protein N-linked glycosylation (HP:0012347)2.22766058
96Abnormal protein glycosylation (HP:0012346)2.22766058
97Abnormal glycosylation (HP:0012345)2.22766058
98Combined immunodeficiency (HP:0005387)2.21854108
99Microretrognathia (HP:0000308)2.20901361
100Autoimmune thrombocytopenia (HP:0001973)2.20557280
101Reduced antithrombin III activity (HP:0001976)2.20154619
102Abnormality of the preputium (HP:0100587)2.19191615
103Abnormality of T cell number (HP:0011839)2.19128605
104Bronchitis (HP:0012387)2.18676221
105Mediastinal lymphadenopathy (HP:0100721)2.17321521
106Oral leukoplakia (HP:0002745)2.16884478
107Lactic acidosis (HP:0003128)2.16703038
108Albinism (HP:0001022)2.16540379
109Pendular nystagmus (HP:0012043)2.15192598
110Type 2 muscle fiber atrophy (HP:0003554)2.14964260
111Abnormality of T cell physiology (HP:0011840)2.14891009
112Chronic diarrhea (HP:0002028)2.14485071
113Aplasia/hypoplasia of the uterus (HP:0008684)2.13726119
114Muscle fiber atrophy (HP:0100295)2.13528354
115Severe visual impairment (HP:0001141)2.13404383
116Type II lissencephaly (HP:0007260)2.12917157
117Microcytic anemia (HP:0001935)2.12444507
118Abnormality of the heme biosynthetic pathway (HP:0010472)2.11954440
119Abnormality of chromosome stability (HP:0003220)2.11834665
120Abnormal albumin level (HP:0012116)2.10908719
121Hypoalbuminemia (HP:0003073)2.10908719
122Eczematoid dermatitis (HP:0000976)2.10860053
123Absent thumb (HP:0009777)2.10303158
124Chronic sinusitis (HP:0011109)2.08946899
125Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.07902605
126Recurrent lower respiratory tract infections (HP:0002783)2.07746504
127Basal cell carcinoma (HP:0002671)2.07437663
128Bone marrow hypocellularity (HP:0005528)2.07337903
129Nephronophthisis (HP:0000090)2.04435032
130Abnormality of the fingertips (HP:0001211)2.03539528
131Medulloblastoma (HP:0002885)2.02961722
132Agnosia (HP:0010524)2.02945741
133Gastrointestinal stroma tumor (HP:0100723)2.02563509
134Meckel diverticulum (HP:0002245)2.02481704
135IgA deficiency (HP:0002720)2.02249760
136Constricted visual fields (HP:0001133)2.01630396
137Osteomyelitis (HP:0002754)2.01031781
138Generalized aminoaciduria (HP:0002909)2.00080633
139Abnormality of dicarboxylic acid metabolism (HP:0010995)1.96352575
140Dicarboxylic aciduria (HP:0003215)1.96352575
141Retrobulbar optic neuritis (HP:0100654)1.96261369
142Optic neuritis (HP:0100653)1.96261369
143Clubbing of toes (HP:0100760)1.95375159
144Hypoplasia of the thymus (HP:0000778)1.94432141
145Keratoconus (HP:0000563)1.92974686
146Increased corneal curvature (HP:0100692)1.92974686
147Lethargy (HP:0001254)1.92206294
148Abnormal delayed hypersensitivity skin test (HP:0002963)1.91807141
149Amaurosis fugax (HP:0100576)1.91127852
150Acute myeloid leukemia (HP:0004808)1.90779365
151Hematochezia (HP:0002573)1.90256000
152Abnormality of the ileum (HP:0001549)1.90105736
153Orchitis (HP:0100796)1.88443147
154Chronic mucocutaneous candidiasis (HP:0002728)1.87695721
155Recurrent cutaneous fungal infections (HP:0011370)1.87695721
15611 pairs of ribs (HP:0000878)1.87488308
157Verrucae (HP:0200043)1.87364044
158Papilloma (HP:0012740)1.87364044
159Prominent nose (HP:0000448)1.86570370
160Entropion (HP:0000621)1.86477606
161Gastrointestinal inflammation (HP:0004386)1.85469447
162Abnormality of macrophages (HP:0004311)1.85315210
163Exertional dyspnea (HP:0002875)1.84714145
164Hypoplasia of the uterus (HP:0000013)1.84454815
165Leukocytosis (HP:0001974)1.84344997
166Premature graying of hair (HP:0002216)1.84106089
167Abnormal drinking behavior (HP:0030082)1.83574787
168Polydipsia (HP:0001959)1.83574787
169Medial flaring of the eyebrow (HP:0010747)1.81938020
170Chromsome breakage (HP:0040012)1.81897637
171Abnormality of the renal medulla (HP:0100957)1.81579302
172Exercise intolerance (HP:0003546)1.81126935
173Stomach cancer (HP:0012126)1.80074150
174Cerebral palsy (HP:0100021)1.78895078
175Respiratory failure (HP:0002878)1.76145062
176Granulocytopenia (HP:0001913)1.74518221
177Pulmonary infiltrates (HP:0002113)1.73530616

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.40605881
2MAP4K13.17561135
3CDC73.07103872
4VRK22.84484143
5BCKDK2.77227694
6ACVR1B2.71930873
7ADRBK22.61592455
8MAP3K102.56027410
9STK162.55890194
10WEE12.41835249
11FRK2.34450357
12TAOK32.30924981
13MAP4K22.30840821
14TGFBR12.28120913
15BUB12.26666741
16GRK12.16902942
17EIF2AK12.05955858
18EIF2AK32.01582018
19DYRK31.97674212
20SRPK11.90682427
21RPS6KA41.89112890
22ZAP701.88459209
23VRK11.80515932
24KDR1.78141289
25BTK1.74799929
26KIT1.67924028
27TEC1.65852577
28CSF1R1.65605631
29TXK1.65031363
30MST41.63136470
31NLK1.59807409
32TGFBR21.59605227
33TESK21.53401232
34FES1.50773458
35PINK11.50528299
36GRK71.48632805
37ZAK1.48622498
38PIM21.43862794
39MKNK11.43720688
40NEK21.41148687
41MAP3K121.39701853
42TIE11.37361182
43LIMK11.35353593
44WNK41.35290823
45IRAK41.33770479
46EEF2K1.26898697
47PIM11.24561127
48STK101.23896063
49TBK11.23813976
50PASK1.22038916
51SYK1.19328522
52ATR1.18786864
53CDK71.18749631
54JAK31.18687405
55SIK31.14789868
56TLK11.13781663
57NUAK11.13636422
58GRK61.12064741
59ERBB31.10862944
60IKBKE1.08526229
61CAMKK21.08289102
62STK41.07124879
63BLK1.02659410
64PRKCQ1.02204113
65SCYL21.01727757
66AURKB0.98436988
67INSRR0.97770525
68LRRK20.95263079
69PLK40.94633583
70CLK10.93931275
71DAPK20.93218962
72CDK40.88980351
73IKBKB0.88744805
74FLT30.85159764
75MAPK130.84117287
76WNK30.83731115
77MAP2K30.82639958
78MAP3K140.80433579
79LYN0.80341138
80OXSR10.79727703
81TYK20.79362468
82RPS6KB20.78988301
83TNK20.78975343
84TNIK0.78791490
85PLK10.77932357
86LCK0.75463140
87MKNK20.75181205
88ADRBK10.74230971
89TESK10.74173163
90ITK0.73139436
91BMPR20.72661321
92DYRK20.68527124
93MAP2K20.65566984
94GRK50.65346280
95CDK120.63926768
96CDK80.62894683
97CDK190.62712004
98RPS6KA50.62488133
99MAP3K110.61355235
100CHUK0.60960228
101PIK3CA0.60683960
102TRIM280.59926785
103CHEK20.58853745
104MAP2K70.58653038
105AURKA0.57396292
106BRSK20.56613176
107PLK30.55366488
108TSSK60.54978578
109HCK0.54737859
110YES10.54727906
111EIF2AK20.52201069
112TAOK20.52084153
113CSK0.51641402
114STK390.51424941
115PIK3CG0.48883394
116CSNK2A10.47600775
117IRAK30.47411311
118OBSCN0.47057426
119IGF1R0.47045450
120CSNK1G30.46462599
121MAP2K60.46309972
122PHKG20.44745682
123PHKG10.44745682
124PRKCA0.44163222
125MAPKAPK20.43538966
126CDK90.42778307
127PLK20.42624029
128CSNK1G10.41681868
129BRD40.41261895
130PRKACA0.40956903
131PRKCE0.40768622
132MUSK0.40177576
133RIPK40.40108197
134MYLK0.40038579
135BCR0.39655296
136CCNB10.39500451
137ILK0.38766201
138MAPKAPK30.38674627
139STK240.38587138
140DAPK10.38418792
141MELK0.38014651
142CSNK1A1L0.37635980
143BMPR1B0.37429083
144CSNK1G20.37262500
145CSNK2A20.36356167
146CHEK10.36298378
147CDK20.36143208
148CAMK2A0.34897204
149PTK2B0.34639202
150CDK60.34390626
151ABL10.34306984
152CSNK1A10.33492937
153CAMKK10.33359744

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.80506692
2Mismatch repair_Homo sapiens_hsa034303.68074445
3Base excision repair_Homo sapiens_hsa034103.30110790
4Ribosome_Homo sapiens_hsa030103.25372820
5Oxidative phosphorylation_Homo sapiens_hsa001903.04410145
6Spliceosome_Homo sapiens_hsa030402.70349374
7Primary immunodeficiency_Homo sapiens_hsa053402.62477755
8Homologous recombination_Homo sapiens_hsa034402.60745721
9Nucleotide excision repair_Homo sapiens_hsa034202.55459620
10Proteasome_Homo sapiens_hsa030502.52877537
11Type I diabetes mellitus_Homo sapiens_hsa049402.52266694
12Parkinsons disease_Homo sapiens_hsa050122.46493683
13RNA polymerase_Homo sapiens_hsa030202.32433972
14Pyrimidine metabolism_Homo sapiens_hsa002402.24905224
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.23491887
16Cell cycle_Homo sapiens_hsa041102.12812834
17Phototransduction_Homo sapiens_hsa047442.03553230
18RNA transport_Homo sapiens_hsa030131.88208961
19Caffeine metabolism_Homo sapiens_hsa002321.84269647
20Rheumatoid arthritis_Homo sapiens_hsa053231.84123721
21Fanconi anemia pathway_Homo sapiens_hsa034601.82225205
22Non-homologous end-joining_Homo sapiens_hsa034501.74524538
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70047149
24p53 signaling pathway_Homo sapiens_hsa041151.56762677
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.55725448
26RNA degradation_Homo sapiens_hsa030181.52947173
27Nitrogen metabolism_Homo sapiens_hsa009101.51597990
28Antigen processing and presentation_Homo sapiens_hsa046121.50912446
29Alzheimers disease_Homo sapiens_hsa050101.50611809
30Herpes simplex infection_Homo sapiens_hsa051681.45085111
31Hematopoietic cell lineage_Homo sapiens_hsa046401.42253964
32One carbon pool by folate_Homo sapiens_hsa006701.41189821
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40792759
34Huntingtons disease_Homo sapiens_hsa050161.38512536
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.38198679
36Measles_Homo sapiens_hsa051621.34191532
37Leishmaniasis_Homo sapiens_hsa051401.32434014
38Linoleic acid metabolism_Homo sapiens_hsa005911.32174451
39B cell receptor signaling pathway_Homo sapiens_hsa046621.28577566
40* Systemic lupus erythematosus_Homo sapiens_hsa053221.28074479
41Basal transcription factors_Homo sapiens_hsa030221.23988036
42Purine metabolism_Homo sapiens_hsa002301.23256411
43Asthma_Homo sapiens_hsa053101.16735404
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16598041
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14144134
46Epstein-Barr virus infection_Homo sapiens_hsa051691.11612880
47Cardiac muscle contraction_Homo sapiens_hsa042601.11601362
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11327534
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11188424
50Legionellosis_Homo sapiens_hsa051341.10657627
51* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10283488
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.10073063
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09532718
54Shigellosis_Homo sapiens_hsa051311.06328996
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04765525
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04401881
57Peroxisome_Homo sapiens_hsa041461.02417802
58mRNA surveillance pathway_Homo sapiens_hsa030151.02069392
59Viral carcinogenesis_Homo sapiens_hsa052030.98437358
60Butanoate metabolism_Homo sapiens_hsa006500.97047764
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96512971
62Apoptosis_Homo sapiens_hsa042100.93305597
63Tryptophan metabolism_Homo sapiens_hsa003800.92877839
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.90391095
65HTLV-I infection_Homo sapiens_hsa051660.90233805
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88666496
67Protein export_Homo sapiens_hsa030600.88158296
68T cell receptor signaling pathway_Homo sapiens_hsa046600.87379318
69Hepatitis B_Homo sapiens_hsa051610.86962084
70Other glycan degradation_Homo sapiens_hsa005110.85444577
71Allograft rejection_Homo sapiens_hsa053300.85001693
72N-Glycan biosynthesis_Homo sapiens_hsa005100.84436983
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83332808
74Acute myeloid leukemia_Homo sapiens_hsa052210.82918886
75Olfactory transduction_Homo sapiens_hsa047400.81022515
76Sulfur relay system_Homo sapiens_hsa041220.78598017
77Collecting duct acid secretion_Homo sapiens_hsa049660.78587828
78Chemical carcinogenesis_Homo sapiens_hsa052040.77755449
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76805171
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.76627820
81Sulfur metabolism_Homo sapiens_hsa009200.75198206
82Thyroid cancer_Homo sapiens_hsa052160.74572568
83Osteoclast differentiation_Homo sapiens_hsa043800.74455878
84Staphylococcus aureus infection_Homo sapiens_hsa051500.73479560
85Influenza A_Homo sapiens_hsa051640.73254891
86Retinol metabolism_Homo sapiens_hsa008300.73243041
87Arachidonic acid metabolism_Homo sapiens_hsa005900.72971719
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72528310
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.72284247
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71237675
91Propanoate metabolism_Homo sapiens_hsa006400.70335354
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70053608
93Ether lipid metabolism_Homo sapiens_hsa005650.68314033
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68279567
95Small cell lung cancer_Homo sapiens_hsa052220.65760151
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65131994
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64920654
98Colorectal cancer_Homo sapiens_hsa052100.63022619
99Pertussis_Homo sapiens_hsa051330.61905000
100Regulation of autophagy_Homo sapiens_hsa041400.60163075
101* Alcoholism_Homo sapiens_hsa050340.59580001
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59393071
103Chronic myeloid leukemia_Homo sapiens_hsa052200.58679862
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.57504507
105Viral myocarditis_Homo sapiens_hsa054160.57409678
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.56973218
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.56804450
108Salmonella infection_Homo sapiens_hsa051320.56575532
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55747907
110Selenocompound metabolism_Homo sapiens_hsa004500.55692231
111Nicotine addiction_Homo sapiens_hsa050330.55258073
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54761439
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53533677
114Pentose phosphate pathway_Homo sapiens_hsa000300.52650662
115Toxoplasmosis_Homo sapiens_hsa051450.52432738
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51753763
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51204080
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50212069
119Tuberculosis_Homo sapiens_hsa051520.49846422
120TNF signaling pathway_Homo sapiens_hsa046680.49166811
121Metabolic pathways_Homo sapiens_hsa011000.49138292
122Notch signaling pathway_Homo sapiens_hsa043300.48076246
123Malaria_Homo sapiens_hsa051440.47892014
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46172074
125Fatty acid elongation_Homo sapiens_hsa000620.43113894
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43113268
127Morphine addiction_Homo sapiens_hsa050320.42593764
128Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42528353
129Folate biosynthesis_Homo sapiens_hsa007900.42255519
130Autoimmune thyroid disease_Homo sapiens_hsa053200.42138128
131Taste transduction_Homo sapiens_hsa047420.41061188
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.40947429
133Platelet activation_Homo sapiens_hsa046110.40748893
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40544398
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39339931
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38325621
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37334966
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36951106
139Pancreatic cancer_Homo sapiens_hsa052120.36399456
140Graft-versus-host disease_Homo sapiens_hsa053320.35706492
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35500515
142MicroRNAs in cancer_Homo sapiens_hsa052060.35351306
143Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33432585
144Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32625789
145Cyanoamino acid metabolism_Homo sapiens_hsa004600.31671507
146Non-small cell lung cancer_Homo sapiens_hsa052230.31224892
147Pathways in cancer_Homo sapiens_hsa052000.29298372
148Chemokine signaling pathway_Homo sapiens_hsa040620.28471437
149Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28461860
150Salivary secretion_Homo sapiens_hsa049700.24315011
151Vitamin digestion and absorption_Homo sapiens_hsa049770.20958915

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