HAAO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)7.76256219
2L-phenylalanine catabolic process (GO:0006559)7.69650096
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.69650096
4L-phenylalanine metabolic process (GO:0006558)7.37160058
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.37160058
6omega-hydroxylase P450 pathway (GO:0097267)7.28546323
7* aromatic amino acid family catabolic process (GO:0009074)6.84743180
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.21360963
9kynurenine metabolic process (GO:0070189)6.18603913
10* indole-containing compound catabolic process (GO:0042436)6.06254410
11* indolalkylamine catabolic process (GO:0046218)6.06254410
12* tryptophan catabolic process (GO:0006569)6.06254410
13glyoxylate metabolic process (GO:0046487)5.98996277
14bile acid biosynthetic process (GO:0006699)5.97825401
15* tryptophan metabolic process (GO:0006568)5.69670041
16urea metabolic process (GO:0019627)5.66267046
17urea cycle (GO:0000050)5.66267046
18alpha-linolenic acid metabolic process (GO:0036109)5.58317693
19cysteine metabolic process (GO:0006534)5.50774249
20negative regulation of fibrinolysis (GO:0051918)5.47277709
21high-density lipoprotein particle remodeling (GO:0034375)5.46800099
22drug metabolic process (GO:0017144)5.44693283
23sulfur amino acid catabolic process (GO:0000098)5.40771462
24protein carboxylation (GO:0018214)5.26979349
25peptidyl-glutamic acid carboxylation (GO:0017187)5.26979349
26regulation of fibrinolysis (GO:0051917)5.26662645
27serine family amino acid catabolic process (GO:0009071)5.25866251
28complement activation, alternative pathway (GO:0006957)5.23242083
29nitrogen cycle metabolic process (GO:0071941)5.21564368
30regulation of protein activation cascade (GO:2000257)5.18715289
31bile acid metabolic process (GO:0008206)5.07819406
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.07160541
33* aromatic amino acid family metabolic process (GO:0009072)4.90636697
34lysine catabolic process (GO:0006554)4.86127318
35lysine metabolic process (GO:0006553)4.86127318
36homocysteine metabolic process (GO:0050667)4.84415350
37regulation of complement activation (GO:0030449)4.84092150
38tyrosine metabolic process (GO:0006570)4.83065046
39regulation of cholesterol esterification (GO:0010872)4.80987862
40regulation of triglyceride catabolic process (GO:0010896)4.76879422
41reverse cholesterol transport (GO:0043691)4.72447452
42amino-acid betaine metabolic process (GO:0006577)4.69015215
43protein-lipid complex remodeling (GO:0034368)4.68527337
44macromolecular complex remodeling (GO:0034367)4.68527337
45plasma lipoprotein particle remodeling (GO:0034369)4.68527337
46* alpha-amino acid catabolic process (GO:1901606)4.68184494
47ethanol metabolic process (GO:0006067)4.63044193
48regulation of plasminogen activation (GO:0010755)4.62611478
49oxidative demethylation (GO:0070989)4.60490224
50negative regulation of cholesterol transport (GO:0032375)4.59886763
51negative regulation of sterol transport (GO:0032372)4.59886763
52phospholipid efflux (GO:0033700)4.53499436
53triglyceride homeostasis (GO:0070328)4.53482234
54acylglycerol homeostasis (GO:0055090)4.53482234
55glycine metabolic process (GO:0006544)4.48696359
56cellular ketone body metabolic process (GO:0046950)4.48382884
57coenzyme catabolic process (GO:0009109)4.42973214
58imidazole-containing compound metabolic process (GO:0052803)4.36009028
59bile acid and bile salt transport (GO:0015721)4.35619736
60serine family amino acid metabolic process (GO:0009069)4.33242273
61* cellular amino acid catabolic process (GO:0009063)4.31988778
62glutamate metabolic process (GO:0006536)4.31656196
63plasma lipoprotein particle clearance (GO:0034381)4.28821537
64cellular glucuronidation (GO:0052695)4.27509601
65negative regulation of hemostasis (GO:1900047)4.27051723
66negative regulation of blood coagulation (GO:0030195)4.27051723
67cellular modified amino acid catabolic process (GO:0042219)4.20711225
68ethanol oxidation (GO:0006069)4.19410451
69* indolalkylamine metabolic process (GO:0006586)4.18889930
70phenylpropanoid metabolic process (GO:0009698)4.18669526
71serine family amino acid biosynthetic process (GO:0009070)4.16262048
72alkaloid metabolic process (GO:0009820)4.14204520
73drug catabolic process (GO:0042737)4.12863173
74cholesterol efflux (GO:0033344)4.10432596
75S-adenosylmethionine metabolic process (GO:0046500)4.08847901
76aldehyde catabolic process (GO:0046185)4.08575846
77fat-soluble vitamin biosynthetic process (GO:0042362)4.08252495
78* amine catabolic process (GO:0009310)4.07746427
79* cellular biogenic amine catabolic process (GO:0042402)4.07746427
80arginine metabolic process (GO:0006525)4.02729646
81* benzene-containing compound metabolic process (GO:0042537)3.99509701
82regulation of humoral immune response (GO:0002920)3.97917285
83low-density lipoprotein particle remodeling (GO:0034374)3.97556888
84acute-phase response (GO:0006953)3.95666377
85plasma lipoprotein particle assembly (GO:0034377)3.93755216
86fibrinolysis (GO:0042730)3.91224085
87positive regulation of fatty acid biosynthetic process (GO:0045723)3.89117214
88negative regulation of coagulation (GO:0050819)3.88071061
89ketone body metabolic process (GO:1902224)3.87888989
90positive regulation of blood coagulation (GO:0030194)3.85972690
91positive regulation of hemostasis (GO:1900048)3.85972690
92short-chain fatty acid metabolic process (GO:0046459)3.85286811
93uronic acid metabolic process (GO:0006063)3.81842253
94glucuronate metabolic process (GO:0019585)3.81842253
95acetyl-CoA metabolic process (GO:0006084)3.80399538
96cofactor catabolic process (GO:0051187)3.80225824
97* organic acid catabolic process (GO:0016054)3.79198962
98* carboxylic acid catabolic process (GO:0046395)3.79198962
99complement activation, classical pathway (GO:0006958)3.76645093
100blood coagulation, intrinsic pathway (GO:0007597)3.75327973
101urate metabolic process (GO:0046415)3.74026380
102positive regulation of triglyceride lipase activity (GO:0061365)3.73399176
103positive regulation of lipoprotein lipase activity (GO:0051006)3.73399176
104complement activation (GO:0006956)3.70813130
105drug transmembrane transport (GO:0006855)3.70407614
106positive regulation of lipid catabolic process (GO:0050996)3.69094663
107cholesterol homeostasis (GO:0042632)3.68611341
108negative regulation of protein activation cascade (GO:2000258)3.68173861
109phospholipid homeostasis (GO:0055091)3.68139897
110very-low-density lipoprotein particle assembly (GO:0034379)3.68099696
111regulation of bile acid biosynthetic process (GO:0070857)3.67737784
112protein activation cascade (GO:0072376)3.66868479
113negative regulation of wound healing (GO:0061045)3.64557624
114negative regulation of lipase activity (GO:0060192)3.64521668
115regulation of cholesterol homeostasis (GO:2000188)3.64101671
116sterol homeostasis (GO:0055092)3.63196119
117protein-lipid complex subunit organization (GO:0071825)3.62409885
118exogenous drug catabolic process (GO:0042738)3.61809072
119cytolysis (GO:0019835)3.61271695
120intestinal cholesterol absorption (GO:0030299)3.60027230
121positive regulation of coagulation (GO:0050820)3.59152305
122disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.58133911
123killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.58133911
124aspartate family amino acid catabolic process (GO:0009068)3.57759716
125plasma lipoprotein particle organization (GO:0071827)3.56242213
126lipoprotein metabolic process (GO:0042157)3.45733811
127flavonoid metabolic process (GO:0009812)3.44960993
128heme transport (GO:0015886)3.40591564
129protein-lipid complex assembly (GO:0065005)3.31341413
130regulation of lipoprotein particle clearance (GO:0010984)3.21520016
131opsonization (GO:0008228)3.19302124
132negative regulation of complement activation (GO:0045916)3.17328823

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.38402057
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.23510049
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.03136838
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.43245286
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.22743359
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.13326062
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.87861154
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.08001246
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.94667512
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.23557033
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.23228110
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.10166785
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04786755
14* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.01736477
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9683373
16LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.67308946
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.55798871
18GATA1_22025678_ChIP-Seq_K562_Human1.52336992
19CLOCK_20551151_ChIP-Seq_293T_Human1.47377244
20HTT_18923047_ChIP-ChIP_STHdh_Human1.46004430
21* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42508810
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41737112
23* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40492571
24IRF8_22096565_ChIP-ChIP_GC-B_Human1.36309368
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28920205
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26647310
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25756660
28LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24346640
29RXRA_24833708_ChIP-Seq_LIVER_Mouse1.22434172
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17442001
31* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17170702
32BCL6_27268052_Chip-Seq_Bcells_Human1.12302341
33VDR_24763502_ChIP-Seq_THP-1_Human1.08962999
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03985308
35ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03703032
36VDR_21846776_ChIP-Seq_THP-1_Human0.96847893
37VDR_24787735_ChIP-Seq_THP-1_Human0.96776134
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96005278
39ELF1_20517297_ChIP-Seq_JURKAT_Human0.95449677
40ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95205550
41SPI1_23127762_ChIP-Seq_K562_Human0.93667838
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93121011
43ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92118009
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91854705
45* P300_27268052_Chip-Seq_Bcells_Human0.91419224
46SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90961629
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90565573
48RAC3_21632823_ChIP-Seq_H3396_Human0.89305257
49GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87892012
50E2F1_20622854_ChIP-Seq_HELA_Human0.87520164
51SPI1_20517297_ChIP-Seq_HL60_Human0.86379567
52SPI1_23547873_ChIP-Seq_NB4_Human0.85252308
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84780529
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84657695
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.83258664
56RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82455797
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81498309
58GATA4_25053715_ChIP-Seq_YYC3_Human0.81101851
59SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.80951923
60* SCL_19346495_ChIP-Seq_HPC-7_Human0.80677279
61GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80371013
62AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79991743
63MYC_19829295_ChIP-Seq_ESCs_Human0.79808150
64KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79672871
65ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79266666
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79071342
67FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78550379
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.77832993
69SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77808660
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77375994
71* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.76940406
72GATA3_26560356_Chip-Seq_TH2_Human0.76748190
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.76356799
74RARA_24833708_ChIP-Seq_LIVER_Mouse0.76201704
75STAT4_19710469_ChIP-ChIP_TH1__Mouse0.75805136
76* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.75742649
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.75740737
78IRF1_19129219_ChIP-ChIP_H3396_Human0.73386563
79FOXA1_21572438_ChIP-Seq_LNCaP_Human0.73216739
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.73127747
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73018093
82FOXH1_21741376_ChIP-Seq_ESCs_Human0.72424031
83OCT4_20526341_ChIP-Seq_ESCs_Human0.71996825
84VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.71899025
85GATA1_22383799_ChIP-Seq_G1ME_Mouse0.71747892
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71237647
87NANOG_20526341_ChIP-Seq_ESCs_Human0.71124235
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71086605
89EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.70446571
90STAT1_20625510_ChIP-Seq_HELA_Human0.69979294
91SA1_27219007_Chip-Seq_Bcells_Human0.69581010
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.67889669
93ZNF263_19887448_ChIP-Seq_K562_Human0.66976246
94RARB_24833708_ChIP-Seq_LIVER_Mouse0.66228370
95BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64535127
96LXR_22292898_ChIP-Seq_THP-1_Human0.62271055
97RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62107825
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.61701368
99SALL4_18804426_ChIP-ChIP_XEN_Mouse0.60756691
100CEBPB_22108803_ChIP-Seq_LS180_Human0.60658496
101* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.60548069
102STAT3_1855785_ChIP-Seq_MESCs_Mouse0.59582643
103ESR2_21235772_ChIP-Seq_MCF-7_Human0.58972468
104EGR1_19032775_ChIP-ChIP_M12_Human0.57535756
105NRF2_20460467_ChIP-Seq_MEFs_Mouse0.56299407
106NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.56299407
107AR_20517297_ChIP-Seq_VCAP_Human0.54972939
108E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.54698298
109MYC_19915707_ChIP-ChIP_AK7_Human0.52456227
110GATA1_19941827_ChIP-Seq_MEL_Mouse0.51666313
111PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50980401
112FOXA1_25552417_ChIP-Seq_VCAP_Human0.50310681
113ESET_19884257_ChIP-Seq_ESCs_Mouse0.48654024
114FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48633212
115STAT1_17558387_ChIP-Seq_HELA_Human0.46991296
116TAF2_19829295_ChIP-Seq_ESCs_Human0.45467652
117CBP_21632823_ChIP-Seq_H3396_Human0.45090515
118* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.44578830
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.44368103
120* P53_21459846_ChIP-Seq_SAOS-2_Human0.44291481
121GATA1_19941826_ChIP-Seq_K562_Human0.44263611
122* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44059884
123GATA2_19941826_ChIP-Seq_K562_Human0.43342074
124PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42992381
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42823587
126ESR1_21235772_ChIP-Seq_MCF-7_Human0.42535118
127* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.42471652
128BRD4_27068464_Chip-Seq_AML-cells_Mouse0.42288964
129PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.41020893
130NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.40695754
131GATA6_25053715_ChIP-Seq_YYC3_Human0.40228612
132* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.39229091
133FOXO3_23340844_ChIP-Seq_DLD1_Human0.39031378
134FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.38767680
135NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.38193367
136IRF8_27001747_Chip-Seq_BMDM_Mouse0.36964807
137BCOR_27268052_Chip-Seq_Bcells_Human0.36754143
138SPI1_26923725_Chip-Seq_HPCs_Mouse0.36665916
139CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.36621194
140STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.36591219
141* CDX2_20551321_ChIP-Seq_CACO-2_Human0.36275378
142* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.35764346
143* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.35587251
144SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.34895014
145SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.34781323
146MYC_27129775_Chip-Seq_CORNEA_Mouse0.34540514
147SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.34530377
148ERG_20517297_ChIP-Seq_VCAP_Human0.34454471

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.28710483
2MP0005360_urolithiasis7.66017461
3MP0005085_abnormal_gallbladder_physiolo6.32825353
4MP0005365_abnormal_bile_salt6.07412355
5MP0008875_abnormal_xenobiotic_pharmacok5.09043023
6MP0003806_abnormal_nucleotide_metabolis4.18263568
7MP0003252_abnormal_bile_duct3.88276382
8MP0010329_abnormal_lipoprotein_level3.50504604
9MP0009840_abnormal_foam_cell3.21245518
10MP0005083_abnormal_biliary_tract2.93213631
11MP0005332_abnormal_amino_acid2.90693248
12MP0003195_calcinosis2.89341998
13MP0001666_abnormal_nutrient_absorption2.55483305
14MP0003191_abnormal_cellular_cholesterol2.31476978
15MP0004019_abnormal_vitamin_homeostasis2.26752061
16MP0000609_abnormal_liver_physiology2.15280866
17MP0002138_abnormal_hepatobiliary_system2.08643702
18MP0002118_abnormal_lipid_homeostasis2.07236564
19MP0005319_abnormal_enzyme/_coenzyme1.85751299
20MP0003868_abnormal_feces_composition1.84149488
21MP0001764_abnormal_homeostasis1.72329592
22MP0005584_abnormal_enzyme/coenzyme_acti1.63805424
23MP0002132_abnormal_respiratory_system1.52700713
24MP0003183_abnormal_peptide_metabolism1.51076678
25MP0009697_abnormal_copulation1.50090835
26MP0005451_abnormal_body_composition1.48470392
27MP0009643_abnormal_urine_homeostasis1.39684761
28MP0003186_abnormal_redox_activity1.35729641
29MP0001835_abnormal_antigen_presentation1.32103691
30MP0003011_delayed_dark_adaptation1.27503192
31MP0003656_abnormal_erythrocyte_physiolo1.24506263
32MP0000598_abnormal_liver_morphology1.18979873
33MP0003303_peritoneal_inflammation1.16140932
34MP0002419_abnormal_innate_immunity1.14084969
35MP0005025_abnormal_response_to1.13586176
36MP0000685_abnormal_immune_system1.13438559
37MP0009764_decreased_sensitivity_to1.13227527
38MP0003172_abnormal_lysosome_physiology1.11885017
39MP0005647_abnormal_sex_gland1.09273374
40MP0005636_abnormal_mineral_homeostasis1.04377335
41MP0003705_abnormal_hypodermis_morpholog1.04157345
42MP0000604_amyloidosis1.03810797
43MP0009763_increased_sensitivity_to1.03396944
44MP0010155_abnormal_intestine_physiology1.01703545
45MP0008469_abnormal_protein_level0.97613986
46MP0002148_abnormal_hypersensitivity_rea0.96199584
47MP0001790_abnormal_immune_system0.96121424
48MP0005387_immune_system_phenotype0.96121424
49MP0001800_abnormal_humoral_immune0.93070440
50MP0001545_abnormal_hematopoietic_system0.91911184
51MP0005397_hematopoietic_system_phenotyp0.91911184
52MP0002254_reproductive_system_inflammat0.90609152
53MP0009642_abnormal_blood_homeostasis0.90335174
54MP0006036_abnormal_mitochondrial_physio0.89854614
55MP0010368_abnormal_lymphatic_system0.85442560
56MP0005408_hypopigmentation0.85097482
57MP0005000_abnormal_immune_tolerance0.83968016
58MP0002876_abnormal_thyroid_physiology0.83438032
59MP0005084_abnormal_gallbladder_morpholo0.82547002
60MP0009765_abnormal_xenobiotic_induced0.79537389
61MP0005376_homeostasis/metabolism_phenot0.79180764
62MP0002078_abnormal_glucose_homeostasis0.76564946
63MP0002723_abnormal_immune_serum0.75388613
64MP0005670_abnormal_white_adipose0.75306438
65MP0005220_abnormal_exocrine_pancreas0.72619987
66MP0002452_abnormal_antigen_presenting0.70617952
67MP0001756_abnormal_urination0.70277856
68MP0002971_abnormal_brown_adipose0.69420128
69MP0005535_abnormal_body_temperature0.68920870
70MP0003879_abnormal_hair_cell0.67948559
71MP0005334_abnormal_fat_pad0.67641448
72MP0001661_extended_life_span0.64287829
73MP0004130_abnormal_muscle_cell0.63957173
74MP0005464_abnormal_platelet_physiology0.63857548
75MP0005266_abnormal_metabolism0.63709488
76MP0001533_abnormal_skeleton_physiology0.63406129
77MP0003690_abnormal_glial_cell0.62193751
78MP0002136_abnormal_kidney_physiology0.60964946
79MP0003300_gastrointestinal_ulcer0.60532713
80MP0001986_abnormal_taste_sensitivity0.59719521
81MP0003436_decreased_susceptibility_to0.58192111
82MP0006035_abnormal_mitochondrial_morpho0.58143357
83MP0005671_abnormal_response_to0.57533351
84MP0009053_abnormal_anal_canal0.57107960
85MP0003329_amyloid_beta_deposits0.57016624
86MP0000639_abnormal_adrenal_gland0.55310164
87MP0002420_abnormal_adaptive_immunity0.55234971
88MP0001819_abnormal_immune_cell0.54904439
89MP0002928_abnormal_bile_duct0.53925627
90MP0003724_increased_susceptibility_to0.52748250
91MP0005448_abnormal_energy_balance0.51058507
92MP0005164_abnormal_response_to0.51021705
93MP0003638_abnormal_response/metabolism_0.49708349
94MP0009333_abnormal_splenocyte_physiolog0.49414086
95MP0005395_other_phenotype0.47512789
96MP0008873_increased_physiological_sensi0.46828645
97MP0008874_decreased_physiological_sensi0.46733142
98MP0001853_heart_inflammation0.43272578
99MP0003075_altered_response_to0.43237510
100MP0005166_decreased_susceptibility_to0.41957284
101MP0004782_abnormal_surfactant_physiolog0.41787998
102MP0003718_maternal_effect0.40401028
103MP0002822_catalepsy0.40262985
104MP0001845_abnormal_inflammatory_respons0.40157248
105MP0003953_abnormal_hormone_level0.40033305
106MP0006082_CNS_inflammation0.38792392
107MP0004381_abnormal_hair_follicle0.37825238
108MP0009672_abnormal_birth_weight0.36544654
109MP0005058_abnormal_lysosome_morphology0.36377987
110MP0005666_abnormal_adipose_tissue0.35755226
111MP0008872_abnormal_physiological_respon0.34927870
112MP0002837_dystrophic_cardiac_calcinosis0.34761004
113MP0002168_other_aberrant_phenotype0.34275431
114MP0000249_abnormal_blood_vessel0.33709170
115MP0000230_abnormal_systemic_arterial0.32800791
116MP0009115_abnormal_fat_cell0.32627700
117MP0004043_abnormal_pH_regulation0.31156969
118MP0002970_abnormal_white_adipose0.30724719
119MP0001765_abnormal_ion_homeostasis0.29882511
120MP0002796_impaired_skin_barrier0.29664086
121MP0001243_abnormal_dermal_layer0.28789379
122MP0002135_abnormal_kidney_morphology0.27699769
123MP0000579_abnormal_nail_morphology0.27371958
124MP0004883_abnormal_blood_vessel0.27154223
125MP0005248_abnormal_Harderian_gland0.26570505
126MP0001881_abnormal_mammary_gland0.25654955
127MP0009785_altered_susceptibility_to0.25532617

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.38660856
2Deep venous thrombosis (HP:0002625)7.13130947
3Intrahepatic cholestasis (HP:0001406)7.12767205
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.56772047
5Prolonged partial thromboplastin time (HP:0003645)6.33808262
6Hypobetalipoproteinemia (HP:0003563)6.30954136
7Xanthomatosis (HP:0000991)6.12924300
8Hyperlipoproteinemia (HP:0010980)5.41061281
9Complement deficiency (HP:0004431)5.11996547
10Joint hemorrhage (HP:0005261)4.74998072
11Hypolipoproteinemia (HP:0010981)4.62875193
12Hyperammonemia (HP:0001987)4.62296945
13Hyperglycinemia (HP:0002154)4.44352074
14Ketosis (HP:0001946)4.33418713
15Epidermoid cyst (HP:0200040)4.33174068
16Abnormality of glutamine family amino acid metabolism (HP:0010902)4.32401679
17Abnormality of the common coagulation pathway (HP:0010990)4.31274552
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.28939204
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.22859060
20Abnormality of methionine metabolism (HP:0010901)4.22725718
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.22657019
22Hyperglycinuria (HP:0003108)4.10949169
23Fat malabsorption (HP:0002630)4.04024843
24Abnormality of glycine metabolism (HP:0010895)4.03633089
25Abnormality of serine family amino acid metabolism (HP:0010894)4.03633089
26Hypoalphalipoproteinemia (HP:0003233)3.96644841
27Abnormality of pyrimidine metabolism (HP:0004353)3.88887514
28Hypoglycemic coma (HP:0001325)3.80595057
29Nephritis (HP:0000123)3.74321033
30Abnormality of complement system (HP:0005339)3.74163017
31Abnormality of the intrinsic pathway (HP:0010989)3.64517895
32Conjugated hyperbilirubinemia (HP:0002908)3.63450270
33Hypercholesterolemia (HP:0003124)3.48049322
34Abnormality of fatty-acid metabolism (HP:0004359)3.47341642
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.40058523
36Hyperbilirubinemia (HP:0002904)3.33926100
37Delayed CNS myelination (HP:0002188)3.23465264
38Abnormality of nucleobase metabolism (HP:0010932)3.21875203
39Purpura (HP:0000979)3.18719533
40Ketoacidosis (HP:0001993)3.13391552
41Abnormality of serum amino acid levels (HP:0003112)3.10270782
42Steatorrhea (HP:0002570)3.07195734
43Hepatocellular carcinoma (HP:0001402)2.97074212
44Myocardial infarction (HP:0001658)2.93239659
45Spontaneous abortion (HP:0005268)2.88773935
46Pulmonary embolism (HP:0002204)2.88657136
47Abnormality of purine metabolism (HP:0004352)2.88369048
48Metabolic acidosis (HP:0001942)2.84287498
49Hypochromic microcytic anemia (HP:0004840)2.83493752
50Gout (HP:0001997)2.77296164
51Systemic lupus erythematosus (HP:0002725)2.71351781
52Dicarboxylic aciduria (HP:0003215)2.69207806
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.69207806
54Vascular calcification (HP:0004934)2.69006660
55Lethargy (HP:0001254)2.65764269
56Skin nodule (HP:0200036)2.61848201
57Spastic diplegia (HP:0001264)2.48838411
58Acanthocytosis (HP:0001927)2.47896819
59Mitral stenosis (HP:0001718)2.47875407
60Recurrent gram-negative bacterial infections (HP:0005420)2.44478455
61Cerebral edema (HP:0002181)2.42795135
62Neonatal onset (HP:0003623)2.42156756
63Irritability (HP:0000737)2.39205623
64Hypoglycemic seizures (HP:0002173)2.38700991
65Glomerulonephritis (HP:0000099)2.37706244
66Epistaxis (HP:0000421)2.37575693
67Cardiovascular calcification (HP:0011915)2.37375185
68Abnormal gallbladder morphology (HP:0012437)2.35128941
69Gangrene (HP:0100758)2.31187069
70Malnutrition (HP:0004395)2.30972647
71Generalized aminoaciduria (HP:0002909)2.30728035
72Cholelithiasis (HP:0001081)2.29209906
73Amyloidosis (HP:0011034)2.24844092
74Gingival bleeding (HP:0000225)2.22527065
75Cholecystitis (HP:0001082)2.21279928
76Abnormal gallbladder physiology (HP:0012438)2.21279928
77Orchitis (HP:0100796)2.20225891
78Sensorimotor neuropathy (HP:0007141)2.18321079
79Late onset (HP:0003584)2.17869438
80Pancreatitis (HP:0001733)2.17047238
81Vomiting (HP:0002013)2.16553331
82Joint swelling (HP:0001386)2.16250862
83Esophageal varix (HP:0002040)2.14234541
84Myositis (HP:0100614)2.14058489
85Enlarged kidneys (HP:0000105)2.13528606
86Retrobulbar optic neuritis (HP:0100654)2.13032984
87Optic neuritis (HP:0100653)2.13032984
88Menorrhagia (HP:0000132)2.12810505
89Thrombophlebitis (HP:0004418)2.12460799
90Brushfield spots (HP:0001088)2.09694170
91Alkalosis (HP:0001948)2.08565809
92Meningitis (HP:0001287)2.04447820
93Opisthotonus (HP:0002179)2.03038099
94Cerebral palsy (HP:0100021)2.03032886
95Rickets (HP:0002748)2.00219502
96Increased serum ferritin (HP:0003281)2.00084570
97Abnormality of vitamin metabolism (HP:0100508)1.99101117
98Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98986277
99Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98986277
100Abnormality of polysaccharide metabolism (HP:0011012)1.98986277
101Mucopolysacchariduria (HP:0008155)1.98755867
102Urinary glycosaminoglycan excretion (HP:0003541)1.98755867
103Vacuolated lymphocytes (HP:0001922)1.98288682
104Neonatal hypoglycemia (HP:0001998)1.97802754
105Hydroxyprolinuria (HP:0003080)1.97456135
106Abnormality of proline metabolism (HP:0010907)1.97456135
107Proximal tubulopathy (HP:0000114)1.96981682
108Hemorrhage of the eye (HP:0011885)1.95983136
109Poikilocytosis (HP:0004447)1.95264166
110Abnormality of the gallbladder (HP:0005264)1.94212200
111Abnormality of urine glucose concentration (HP:0011016)1.93811733
112Abnormality of iron homeostasis (HP:0011031)1.92823441
113Abnormal enzyme/coenzyme activity (HP:0012379)1.90893971
114Renal cortical cysts (HP:0000803)1.90810644
115Abnormality of transition element cation homeostasis (HP:0011030)1.90348021
116Increased purine levels (HP:0004368)1.90143373
117Hyperuricemia (HP:0002149)1.90143373
118Hyperinsulinemic hypoglycemia (HP:0000825)1.89615246
119Abnormal cartilage morphology (HP:0002763)1.88187480
120Elevated hepatic transaminases (HP:0002910)1.88091859
121Hypophosphatemic rickets (HP:0004912)1.87213429
122Glycosuria (HP:0003076)1.81392692
123Anorexia (HP:0002039)1.77235374
124Fair hair (HP:0002286)1.76738777
125Dysostosis multiplex (HP:0000943)1.74369282
126Abnormality of the prostate (HP:0008775)1.73697893
127Pulmonary infiltrates (HP:0002113)1.71579300
128Hypophosphatemia (HP:0002148)1.69812402
129Chronic obstructive pulmonary disease (HP:0006510)1.68602355
130Obstructive lung disease (HP:0006536)1.68602355
131Increased neuronal autofluorescent lipopigment (HP:0002074)1.67172219
132Prolonged bleeding time (HP:0003010)1.66926307
133Increased cerebral lipofuscin (HP:0011813)1.65758094
134Abnormality of alkaline phosphatase activity (HP:0004379)1.65739677
135Abnormal platelet function (HP:0011869)1.65062793

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.22841483
2FGFR44.56508037
3ERN14.53497232
4SIK14.50527578
5TAOK33.09501647
6ACVR1B2.78344307
7INSRR2.67645876
8ERBB42.59462410
9RIPK42.29089693
10PKN22.21247896
11FLT32.10619557
12MAP2K42.08723799
13TNK21.96631913
14MST1R1.95674701
15TYK21.94252791
16MAPK111.89248358
17PIK3CG1.80543930
18TRIB31.78605823
19TXK1.55732964
20ABL21.46166229
21MATK1.44959204
22GRK61.43699268
23PTK61.41429954
24NEK91.39652238
25TBK11.39328078
26KDR1.38553458
27MAP3K141.34856027
28DAPK21.29259983
29JAK21.27210897
30MAP2K31.24745205
31MAP3K71.23415292
32LATS11.19762132
33IRAK41.18543382
34JAK11.15305974
35FRK1.14629021
36AKT31.11802471
37PRKAA21.07766135
38MAP3K101.07646138
39FGFR21.07368972
40TEC1.06249788
41PINK11.05783450
42MAP4K21.03590667
43BMPR21.02657999
44FES0.99808126
45MAPK40.99166207
46CSF1R0.96234527
47IRAK10.95358288
48MAP4K10.95247126
49IRAK30.91128044
50PDK20.88501827
51LCK0.88332120
52PRKCZ0.87876050
53EPHB10.86144680
54MAP3K30.85439981
55CSK0.85294333
56STK38L0.82525846
57ERBB20.82163698
58PIK3CA0.81542228
59MAP3K110.79036706
60MAPK120.78699350
61MAPK150.77630834
62CDK60.76169985
63IKBKE0.74552470
64OXSR10.74522984
65DYRK1B0.74013191
66GRK70.71406818
67MAP3K20.70131755
68MAPKAPK30.70117700
69PRKACG0.69736258
70TGFBR20.68980484
71TIE10.68883757
72MAP2K60.68373989
73DAPK10.68317708
74HCK0.67065120
75PRKG20.66942997
76MAP3K130.66383817
77TESK20.66111547
78GSK3A0.64767619
79FER0.64432555
80KIT0.63674458
81SGK30.63594539
82PIM20.63572169
83PRKAA10.61564089
84PRKCQ0.60978308
85MAP3K10.60624795
86FGR0.59717826
87LMTK20.59178289
88ADRBK20.58782246
89EPHA30.57873403
90MET0.56392141
91CAMK2G0.55963215
92CAMK1D0.55682575
93PDPK10.55609277
94TLK10.53969892
95FGFR30.53323451
96MAP2K20.50664064
97NLK0.50439942
98MAPK70.49588694
99CSNK1G10.49310577
100CHUK0.49160495
101NUAK10.48513200
102RIPK10.48479419
103MAP3K50.47199010
104CDK40.46855743
105GRK10.46185791
106SGK20.46162810
107BLK0.45733590
108BTK0.44546386
109TAOK20.44070818
110PTK20.42382737
111PDK10.41570213
112PRKCA0.40819355
113IGF1R0.40269859
114PRPF4B0.39769020
115MAPK30.39320835
116CDC42BPA0.38723139
117PRKACA0.38686056
118SGK2230.35099047
119SGK4940.35099047
120ITK0.33833227
121ZAK0.33151292
122EGFR0.31537437
123LYN0.31248138
124CAMK40.30622842
125MAP3K60.30134314
126ZAP700.29894364
127CSNK1G30.29287697
128PDK40.29015555
129PDK30.29015555
130PRKCG0.28502874
131RET0.28416157
132WNK30.27977886
133ABL10.27758256
134CSNK1G20.27290234
135JAK30.27089990
136MTOR0.26622214
137MAP2K10.26620275
138PKN10.26321643
139IKBKB0.24960184
140SYK0.24068022

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.48517284
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.44132671
3Nitrogen metabolism_Homo sapiens_hsa009103.42871631
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.41452206
5Arginine biosynthesis_Homo sapiens_hsa002203.02845191
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68423361
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67746362
8Complement and coagulation cascades_Homo sapiens_hsa046102.67735290
9* Tryptophan metabolism_Homo sapiens_hsa003802.61717055
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.56138316
11Fatty acid degradation_Homo sapiens_hsa000712.48978274
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.43787287
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.34650979
14Butanoate metabolism_Homo sapiens_hsa006502.20018112
15Peroxisome_Homo sapiens_hsa041462.14892163
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11914529
17Propanoate metabolism_Homo sapiens_hsa006401.97847525
18Chemical carcinogenesis_Homo sapiens_hsa052041.93272858
19Histidine metabolism_Homo sapiens_hsa003401.91419389
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.90856954
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.90270482
22PPAR signaling pathway_Homo sapiens_hsa033201.84113115
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.79563134
24Fatty acid metabolism_Homo sapiens_hsa012121.78948052
25beta-Alanine metabolism_Homo sapiens_hsa004101.73583512
26Caffeine metabolism_Homo sapiens_hsa002321.72146548
27Staphylococcus aureus infection_Homo sapiens_hsa051501.72116753
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71732992
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69184949
30Retinol metabolism_Homo sapiens_hsa008301.68277995
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65205620
32Selenocompound metabolism_Homo sapiens_hsa004501.60638853
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58356349
34Phenylalanine metabolism_Homo sapiens_hsa003601.55572798
35Bile secretion_Homo sapiens_hsa049761.48000353
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43495631
37Pyruvate metabolism_Homo sapiens_hsa006201.41489968
38Tyrosine metabolism_Homo sapiens_hsa003501.40976118
39Sulfur metabolism_Homo sapiens_hsa009201.36816451
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.31962900
41Fatty acid elongation_Homo sapiens_hsa000621.29644937
42Starch and sucrose metabolism_Homo sapiens_hsa005001.29540568
43Folate biosynthesis_Homo sapiens_hsa007901.25298077
44Biosynthesis of amino acids_Homo sapiens_hsa012301.21025101
45ABC transporters_Homo sapiens_hsa020101.18058404
46Steroid biosynthesis_Homo sapiens_hsa001001.16983056
47Carbon metabolism_Homo sapiens_hsa012001.15646714
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.15579028
49Fat digestion and absorption_Homo sapiens_hsa049751.08305954
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07739494
51Other glycan degradation_Homo sapiens_hsa005111.04981869
52Sulfur relay system_Homo sapiens_hsa041220.99177832
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98826430
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.98654447
55Arginine and proline metabolism_Homo sapiens_hsa003300.97890401
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91156560
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89719610
58Vitamin digestion and absorption_Homo sapiens_hsa049770.89492147
59Vitamin B6 metabolism_Homo sapiens_hsa007500.88447878
60Lysine degradation_Homo sapiens_hsa003100.83942432
61Asthma_Homo sapiens_hsa053100.82117344
62One carbon pool by folate_Homo sapiens_hsa006700.79066947
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.74647198
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71504852
65Glutathione metabolism_Homo sapiens_hsa004800.70365211
66Glycerolipid metabolism_Homo sapiens_hsa005610.67137434
67Allograft rejection_Homo sapiens_hsa053300.65517530
68Pentose phosphate pathway_Homo sapiens_hsa000300.62325032
69Autoimmune thyroid disease_Homo sapiens_hsa053200.54091218
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53690200
71Graft-versus-host disease_Homo sapiens_hsa053320.51678561
72* Metabolic pathways_Homo sapiens_hsa011000.46299995
73Fatty acid biosynthesis_Homo sapiens_hsa000610.45494332
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41136032
75Type I diabetes mellitus_Homo sapiens_hsa049400.38505292
76Leishmaniasis_Homo sapiens_hsa051400.37818852
77Mineral absorption_Homo sapiens_hsa049780.36608162
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31991759
79Prion diseases_Homo sapiens_hsa050200.29902178
80Fructose and mannose metabolism_Homo sapiens_hsa000510.26210239
81Galactose metabolism_Homo sapiens_hsa000520.25658238
82Insulin resistance_Homo sapiens_hsa049310.22453618
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21513424
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.20357806
85Antigen processing and presentation_Homo sapiens_hsa046120.16215484
86Linoleic acid metabolism_Homo sapiens_hsa005910.15655862
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15271127
88Sphingolipid metabolism_Homo sapiens_hsa006000.14771667
89Ether lipid metabolism_Homo sapiens_hsa005650.12157646
90Rheumatoid arthritis_Homo sapiens_hsa053230.12039874
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.11396100
92Primary immunodeficiency_Homo sapiens_hsa053400.10248763
93Tuberculosis_Homo sapiens_hsa051520.09065048
94Glucagon signaling pathway_Homo sapiens_hsa049220.06483103
95Hematopoietic cell lineage_Homo sapiens_hsa046400.05937565
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.03455861
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.00807365
98Lysosome_Homo sapiens_hsa04142-0.2512350
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2497635
100Pertussis_Homo sapiens_hsa05133-0.2315087
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2167442
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.2041575
103Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1991824
104Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1981390
105Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1709468
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1679106
107Hepatitis C_Homo sapiens_hsa05160-0.1622787
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1614008
109Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1596583
110Renin-angiotensin system_Homo sapiens_hsa04614-0.1595146
111Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1521805
112African trypanosomiasis_Homo sapiens_hsa05143-0.1380429
113Regulation of autophagy_Homo sapiens_hsa04140-0.1256841
114Insulin signaling pathway_Homo sapiens_hsa04910-0.1248620
115Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1180353
116Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1034428
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0751743
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0302131
119AMPK signaling pathway_Homo sapiens_hsa04152-0.0074460

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »