Rank | Gene Set | Z-score |
---|---|---|
1 | epoxygenase P450 pathway (GO:0019373) | 7.76256219 |
2 | L-phenylalanine catabolic process (GO:0006559) | 7.69650096 |
3 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 7.69650096 |
4 | L-phenylalanine metabolic process (GO:0006558) | 7.37160058 |
5 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 7.37160058 |
6 | omega-hydroxylase P450 pathway (GO:0097267) | 7.28546323 |
7 | * aromatic amino acid family catabolic process (GO:0009074) | 6.84743180 |
8 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 6.21360963 |
9 | kynurenine metabolic process (GO:0070189) | 6.18603913 |
10 | * indole-containing compound catabolic process (GO:0042436) | 6.06254410 |
11 | * indolalkylamine catabolic process (GO:0046218) | 6.06254410 |
12 | * tryptophan catabolic process (GO:0006569) | 6.06254410 |
13 | glyoxylate metabolic process (GO:0046487) | 5.98996277 |
14 | bile acid biosynthetic process (GO:0006699) | 5.97825401 |
15 | * tryptophan metabolic process (GO:0006568) | 5.69670041 |
16 | urea metabolic process (GO:0019627) | 5.66267046 |
17 | urea cycle (GO:0000050) | 5.66267046 |
18 | alpha-linolenic acid metabolic process (GO:0036109) | 5.58317693 |
19 | cysteine metabolic process (GO:0006534) | 5.50774249 |
20 | negative regulation of fibrinolysis (GO:0051918) | 5.47277709 |
21 | high-density lipoprotein particle remodeling (GO:0034375) | 5.46800099 |
22 | drug metabolic process (GO:0017144) | 5.44693283 |
23 | sulfur amino acid catabolic process (GO:0000098) | 5.40771462 |
24 | protein carboxylation (GO:0018214) | 5.26979349 |
25 | peptidyl-glutamic acid carboxylation (GO:0017187) | 5.26979349 |
26 | regulation of fibrinolysis (GO:0051917) | 5.26662645 |
27 | serine family amino acid catabolic process (GO:0009071) | 5.25866251 |
28 | complement activation, alternative pathway (GO:0006957) | 5.23242083 |
29 | nitrogen cycle metabolic process (GO:0071941) | 5.21564368 |
30 | regulation of protein activation cascade (GO:2000257) | 5.18715289 |
31 | bile acid metabolic process (GO:0008206) | 5.07819406 |
32 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 5.07160541 |
33 | * aromatic amino acid family metabolic process (GO:0009072) | 4.90636697 |
34 | lysine catabolic process (GO:0006554) | 4.86127318 |
35 | lysine metabolic process (GO:0006553) | 4.86127318 |
36 | homocysteine metabolic process (GO:0050667) | 4.84415350 |
37 | regulation of complement activation (GO:0030449) | 4.84092150 |
38 | tyrosine metabolic process (GO:0006570) | 4.83065046 |
39 | regulation of cholesterol esterification (GO:0010872) | 4.80987862 |
40 | regulation of triglyceride catabolic process (GO:0010896) | 4.76879422 |
41 | reverse cholesterol transport (GO:0043691) | 4.72447452 |
42 | amino-acid betaine metabolic process (GO:0006577) | 4.69015215 |
43 | protein-lipid complex remodeling (GO:0034368) | 4.68527337 |
44 | macromolecular complex remodeling (GO:0034367) | 4.68527337 |
45 | plasma lipoprotein particle remodeling (GO:0034369) | 4.68527337 |
46 | * alpha-amino acid catabolic process (GO:1901606) | 4.68184494 |
47 | ethanol metabolic process (GO:0006067) | 4.63044193 |
48 | regulation of plasminogen activation (GO:0010755) | 4.62611478 |
49 | oxidative demethylation (GO:0070989) | 4.60490224 |
50 | negative regulation of cholesterol transport (GO:0032375) | 4.59886763 |
51 | negative regulation of sterol transport (GO:0032372) | 4.59886763 |
52 | phospholipid efflux (GO:0033700) | 4.53499436 |
53 | triglyceride homeostasis (GO:0070328) | 4.53482234 |
54 | acylglycerol homeostasis (GO:0055090) | 4.53482234 |
55 | glycine metabolic process (GO:0006544) | 4.48696359 |
56 | cellular ketone body metabolic process (GO:0046950) | 4.48382884 |
57 | coenzyme catabolic process (GO:0009109) | 4.42973214 |
58 | imidazole-containing compound metabolic process (GO:0052803) | 4.36009028 |
59 | bile acid and bile salt transport (GO:0015721) | 4.35619736 |
60 | serine family amino acid metabolic process (GO:0009069) | 4.33242273 |
61 | * cellular amino acid catabolic process (GO:0009063) | 4.31988778 |
62 | glutamate metabolic process (GO:0006536) | 4.31656196 |
63 | plasma lipoprotein particle clearance (GO:0034381) | 4.28821537 |
64 | cellular glucuronidation (GO:0052695) | 4.27509601 |
65 | negative regulation of hemostasis (GO:1900047) | 4.27051723 |
66 | negative regulation of blood coagulation (GO:0030195) | 4.27051723 |
67 | cellular modified amino acid catabolic process (GO:0042219) | 4.20711225 |
68 | ethanol oxidation (GO:0006069) | 4.19410451 |
69 | * indolalkylamine metabolic process (GO:0006586) | 4.18889930 |
70 | phenylpropanoid metabolic process (GO:0009698) | 4.18669526 |
71 | serine family amino acid biosynthetic process (GO:0009070) | 4.16262048 |
72 | alkaloid metabolic process (GO:0009820) | 4.14204520 |
73 | drug catabolic process (GO:0042737) | 4.12863173 |
74 | cholesterol efflux (GO:0033344) | 4.10432596 |
75 | S-adenosylmethionine metabolic process (GO:0046500) | 4.08847901 |
76 | aldehyde catabolic process (GO:0046185) | 4.08575846 |
77 | fat-soluble vitamin biosynthetic process (GO:0042362) | 4.08252495 |
78 | * amine catabolic process (GO:0009310) | 4.07746427 |
79 | * cellular biogenic amine catabolic process (GO:0042402) | 4.07746427 |
80 | arginine metabolic process (GO:0006525) | 4.02729646 |
81 | * benzene-containing compound metabolic process (GO:0042537) | 3.99509701 |
82 | regulation of humoral immune response (GO:0002920) | 3.97917285 |
83 | low-density lipoprotein particle remodeling (GO:0034374) | 3.97556888 |
84 | acute-phase response (GO:0006953) | 3.95666377 |
85 | plasma lipoprotein particle assembly (GO:0034377) | 3.93755216 |
86 | fibrinolysis (GO:0042730) | 3.91224085 |
87 | positive regulation of fatty acid biosynthetic process (GO:0045723) | 3.89117214 |
88 | negative regulation of coagulation (GO:0050819) | 3.88071061 |
89 | ketone body metabolic process (GO:1902224) | 3.87888989 |
90 | positive regulation of blood coagulation (GO:0030194) | 3.85972690 |
91 | positive regulation of hemostasis (GO:1900048) | 3.85972690 |
92 | short-chain fatty acid metabolic process (GO:0046459) | 3.85286811 |
93 | uronic acid metabolic process (GO:0006063) | 3.81842253 |
94 | glucuronate metabolic process (GO:0019585) | 3.81842253 |
95 | acetyl-CoA metabolic process (GO:0006084) | 3.80399538 |
96 | cofactor catabolic process (GO:0051187) | 3.80225824 |
97 | * organic acid catabolic process (GO:0016054) | 3.79198962 |
98 | * carboxylic acid catabolic process (GO:0046395) | 3.79198962 |
99 | complement activation, classical pathway (GO:0006958) | 3.76645093 |
100 | blood coagulation, intrinsic pathway (GO:0007597) | 3.75327973 |
101 | urate metabolic process (GO:0046415) | 3.74026380 |
102 | positive regulation of triglyceride lipase activity (GO:0061365) | 3.73399176 |
103 | positive regulation of lipoprotein lipase activity (GO:0051006) | 3.73399176 |
104 | complement activation (GO:0006956) | 3.70813130 |
105 | drug transmembrane transport (GO:0006855) | 3.70407614 |
106 | positive regulation of lipid catabolic process (GO:0050996) | 3.69094663 |
107 | cholesterol homeostasis (GO:0042632) | 3.68611341 |
108 | negative regulation of protein activation cascade (GO:2000258) | 3.68173861 |
109 | phospholipid homeostasis (GO:0055091) | 3.68139897 |
110 | very-low-density lipoprotein particle assembly (GO:0034379) | 3.68099696 |
111 | regulation of bile acid biosynthetic process (GO:0070857) | 3.67737784 |
112 | protein activation cascade (GO:0072376) | 3.66868479 |
113 | negative regulation of wound healing (GO:0061045) | 3.64557624 |
114 | negative regulation of lipase activity (GO:0060192) | 3.64521668 |
115 | regulation of cholesterol homeostasis (GO:2000188) | 3.64101671 |
116 | sterol homeostasis (GO:0055092) | 3.63196119 |
117 | protein-lipid complex subunit organization (GO:0071825) | 3.62409885 |
118 | exogenous drug catabolic process (GO:0042738) | 3.61809072 |
119 | cytolysis (GO:0019835) | 3.61271695 |
120 | intestinal cholesterol absorption (GO:0030299) | 3.60027230 |
121 | positive regulation of coagulation (GO:0050820) | 3.59152305 |
122 | disruption of cells of other organism involved in symbiotic interaction (GO:0051818) | 3.58133911 |
123 | killing of cells in other organism involved in symbiotic interaction (GO:0051883) | 3.58133911 |
124 | aspartate family amino acid catabolic process (GO:0009068) | 3.57759716 |
125 | plasma lipoprotein particle organization (GO:0071827) | 3.56242213 |
126 | lipoprotein metabolic process (GO:0042157) | 3.45733811 |
127 | flavonoid metabolic process (GO:0009812) | 3.44960993 |
128 | heme transport (GO:0015886) | 3.40591564 |
129 | protein-lipid complex assembly (GO:0065005) | 3.31341413 |
130 | regulation of lipoprotein particle clearance (GO:0010984) | 3.21520016 |
131 | opsonization (GO:0008228) | 3.19302124 |
132 | negative regulation of complement activation (GO:0045916) | 3.17328823 |
Rank | Gene Set | Z-score |
---|---|---|
1 | * RXR_22158963_ChIP-Seq_LIVER_Mouse | 8.38402057 |
2 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 7.23510049 |
3 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 7.03136838 |
4 | * LXR_22158963_ChIP-Seq_LIVER_Mouse | 6.43245286 |
5 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 5.22743359 |
6 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 5.13326062 |
7 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 4.87861154 |
8 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 4.08001246 |
9 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 3.94667512 |
10 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.23557033 |
11 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.23228110 |
12 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 2.10166785 |
13 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.04786755 |
14 | * HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 2.01736477 |
15 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 11.9683373 |
16 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.67308946 |
17 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.55798871 |
18 | GATA1_22025678_ChIP-Seq_K562_Human | 1.52336992 |
19 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.47377244 |
20 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.46004430 |
21 | * RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.42508810 |
22 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.41737112 |
23 | * HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.40492571 |
24 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.36309368 |
25 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.28920205 |
26 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.26647310 |
27 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.25756660 |
28 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.24346640 |
29 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 1.22434172 |
30 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.17442001 |
31 | * MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.17170702 |
32 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.12302341 |
33 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.08962999 |
34 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.03985308 |
35 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.03703032 |
36 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.96847893 |
37 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.96776134 |
38 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.96005278 |
39 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.95449677 |
40 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.95205550 |
41 | SPI1_23127762_ChIP-Seq_K562_Human | 0.93667838 |
42 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.93121011 |
43 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.92118009 |
44 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.91854705 |
45 | * P300_27268052_Chip-Seq_Bcells_Human | 0.91419224 |
46 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.90961629 |
47 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.90565573 |
48 | RAC3_21632823_ChIP-Seq_H3396_Human | 0.89305257 |
49 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.87892012 |
50 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.87520164 |
51 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.86379567 |
52 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.85252308 |
53 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.84780529 |
54 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.84657695 |
55 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.83258664 |
56 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 0.82455797 |
57 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.81498309 |
58 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.81101851 |
59 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.80951923 |
60 | * SCL_19346495_ChIP-Seq_HPC-7_Human | 0.80677279 |
61 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.80371013 |
62 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.79991743 |
63 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.79808150 |
64 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.79672871 |
65 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.79266666 |
66 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.79071342 |
67 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.78550379 |
68 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.77832993 |
69 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.77808660 |
70 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.77375994 |
71 | * SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.76940406 |
72 | GATA3_26560356_Chip-Seq_TH2_Human | 0.76748190 |
73 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.76356799 |
74 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 0.76201704 |
75 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.75805136 |
76 | * SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.75742649 |
77 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.75740737 |
78 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.73386563 |
79 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.73216739 |
80 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.73127747 |
81 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.73018093 |
82 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.72424031 |
83 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.71996825 |
84 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 0.71899025 |
85 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.71747892 |
86 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.71237647 |
87 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.71124235 |
88 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.71086605 |
89 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.70446571 |
90 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.69979294 |
91 | SA1_27219007_Chip-Seq_Bcells_Human | 0.69581010 |
92 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.67889669 |
93 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.66976246 |
94 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.66228370 |
95 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.64535127 |
96 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.62271055 |
97 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.62107825 |
98 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.61701368 |
99 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.60756691 |
100 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.60658496 |
101 | * AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.60548069 |
102 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.59582643 |
103 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.58972468 |
104 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.57535756 |
105 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.56299407 |
106 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.56299407 |
107 | AR_20517297_ChIP-Seq_VCAP_Human | 0.54972939 |
108 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.54698298 |
109 | MYC_19915707_ChIP-ChIP_AK7_Human | 0.52456227 |
110 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.51666313 |
111 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.50980401 |
112 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.50310681 |
113 | ESET_19884257_ChIP-Seq_ESCs_Mouse | 0.48654024 |
114 | FOXA1_26743006_Chip-Seq_LNCaP-abl_Human | 0.48633212 |
115 | STAT1_17558387_ChIP-Seq_HELA_Human | 0.46991296 |
116 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.45467652 |
117 | CBP_21632823_ChIP-Seq_H3396_Human | 0.45090515 |
118 | * FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.44578830 |
119 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.44368103 |
120 | * P53_21459846_ChIP-Seq_SAOS-2_Human | 0.44291481 |
121 | GATA1_19941826_ChIP-Seq_K562_Human | 0.44263611 |
122 | * PPARG_20887899_ChIP-Seq_3T3-L1_Mouse | 0.44059884 |
123 | GATA2_19941826_ChIP-Seq_K562_Human | 0.43342074 |
124 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.42992381 |
125 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.42823587 |
126 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.42535118 |
127 | * GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.42471652 |
128 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 0.42288964 |
129 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.41020893 |
130 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 0.40695754 |
131 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.40228612 |
132 | * CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.39229091 |
133 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.39031378 |
134 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.38767680 |
135 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.38193367 |
136 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 0.36964807 |
137 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.36754143 |
138 | SPI1_26923725_Chip-Seq_HPCs_Mouse | 0.36665916 |
139 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.36621194 |
140 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 0.36591219 |
141 | * CDX2_20551321_ChIP-Seq_CACO-2_Human | 0.36275378 |
142 | * CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.35764346 |
143 | * SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 0.35587251 |
144 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.34895014 |
145 | SOX3_22085726_ChIP-Seq_MUSCLE_Mouse | 0.34781323 |
146 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.34540514 |
147 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.34530377 |
148 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.34454471 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002139_abnormal_hepatobiliary_system | 8.28710483 |
2 | MP0005360_urolithiasis | 7.66017461 |
3 | MP0005085_abnormal_gallbladder_physiolo | 6.32825353 |
4 | MP0005365_abnormal_bile_salt | 6.07412355 |
5 | MP0008875_abnormal_xenobiotic_pharmacok | 5.09043023 |
6 | MP0003806_abnormal_nucleotide_metabolis | 4.18263568 |
7 | MP0003252_abnormal_bile_duct | 3.88276382 |
8 | MP0010329_abnormal_lipoprotein_level | 3.50504604 |
9 | MP0009840_abnormal_foam_cell | 3.21245518 |
10 | MP0005083_abnormal_biliary_tract | 2.93213631 |
11 | MP0005332_abnormal_amino_acid | 2.90693248 |
12 | MP0003195_calcinosis | 2.89341998 |
13 | MP0001666_abnormal_nutrient_absorption | 2.55483305 |
14 | MP0003191_abnormal_cellular_cholesterol | 2.31476978 |
15 | MP0004019_abnormal_vitamin_homeostasis | 2.26752061 |
16 | MP0000609_abnormal_liver_physiology | 2.15280866 |
17 | MP0002138_abnormal_hepatobiliary_system | 2.08643702 |
18 | MP0002118_abnormal_lipid_homeostasis | 2.07236564 |
19 | MP0005319_abnormal_enzyme/_coenzyme | 1.85751299 |
20 | MP0003868_abnormal_feces_composition | 1.84149488 |
21 | MP0001764_abnormal_homeostasis | 1.72329592 |
22 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.63805424 |
23 | MP0002132_abnormal_respiratory_system | 1.52700713 |
24 | MP0003183_abnormal_peptide_metabolism | 1.51076678 |
25 | MP0009697_abnormal_copulation | 1.50090835 |
26 | MP0005451_abnormal_body_composition | 1.48470392 |
27 | MP0009643_abnormal_urine_homeostasis | 1.39684761 |
28 | MP0003186_abnormal_redox_activity | 1.35729641 |
29 | MP0001835_abnormal_antigen_presentation | 1.32103691 |
30 | MP0003011_delayed_dark_adaptation | 1.27503192 |
31 | MP0003656_abnormal_erythrocyte_physiolo | 1.24506263 |
32 | MP0000598_abnormal_liver_morphology | 1.18979873 |
33 | MP0003303_peritoneal_inflammation | 1.16140932 |
34 | MP0002419_abnormal_innate_immunity | 1.14084969 |
35 | MP0005025_abnormal_response_to | 1.13586176 |
36 | MP0000685_abnormal_immune_system | 1.13438559 |
37 | MP0009764_decreased_sensitivity_to | 1.13227527 |
38 | MP0003172_abnormal_lysosome_physiology | 1.11885017 |
39 | MP0005647_abnormal_sex_gland | 1.09273374 |
40 | MP0005636_abnormal_mineral_homeostasis | 1.04377335 |
41 | MP0003705_abnormal_hypodermis_morpholog | 1.04157345 |
42 | MP0000604_amyloidosis | 1.03810797 |
43 | MP0009763_increased_sensitivity_to | 1.03396944 |
44 | MP0010155_abnormal_intestine_physiology | 1.01703545 |
45 | MP0008469_abnormal_protein_level | 0.97613986 |
46 | MP0002148_abnormal_hypersensitivity_rea | 0.96199584 |
47 | MP0001790_abnormal_immune_system | 0.96121424 |
48 | MP0005387_immune_system_phenotype | 0.96121424 |
49 | MP0001800_abnormal_humoral_immune | 0.93070440 |
50 | MP0001545_abnormal_hematopoietic_system | 0.91911184 |
51 | MP0005397_hematopoietic_system_phenotyp | 0.91911184 |
52 | MP0002254_reproductive_system_inflammat | 0.90609152 |
53 | MP0009642_abnormal_blood_homeostasis | 0.90335174 |
54 | MP0006036_abnormal_mitochondrial_physio | 0.89854614 |
55 | MP0010368_abnormal_lymphatic_system | 0.85442560 |
56 | MP0005408_hypopigmentation | 0.85097482 |
57 | MP0005000_abnormal_immune_tolerance | 0.83968016 |
58 | MP0002876_abnormal_thyroid_physiology | 0.83438032 |
59 | MP0005084_abnormal_gallbladder_morpholo | 0.82547002 |
60 | MP0009765_abnormal_xenobiotic_induced | 0.79537389 |
61 | MP0005376_homeostasis/metabolism_phenot | 0.79180764 |
62 | MP0002078_abnormal_glucose_homeostasis | 0.76564946 |
63 | MP0002723_abnormal_immune_serum | 0.75388613 |
64 | MP0005670_abnormal_white_adipose | 0.75306438 |
65 | MP0005220_abnormal_exocrine_pancreas | 0.72619987 |
66 | MP0002452_abnormal_antigen_presenting | 0.70617952 |
67 | MP0001756_abnormal_urination | 0.70277856 |
68 | MP0002971_abnormal_brown_adipose | 0.69420128 |
69 | MP0005535_abnormal_body_temperature | 0.68920870 |
70 | MP0003879_abnormal_hair_cell | 0.67948559 |
71 | MP0005334_abnormal_fat_pad | 0.67641448 |
72 | MP0001661_extended_life_span | 0.64287829 |
73 | MP0004130_abnormal_muscle_cell | 0.63957173 |
74 | MP0005464_abnormal_platelet_physiology | 0.63857548 |
75 | MP0005266_abnormal_metabolism | 0.63709488 |
76 | MP0001533_abnormal_skeleton_physiology | 0.63406129 |
77 | MP0003690_abnormal_glial_cell | 0.62193751 |
78 | MP0002136_abnormal_kidney_physiology | 0.60964946 |
79 | MP0003300_gastrointestinal_ulcer | 0.60532713 |
80 | MP0001986_abnormal_taste_sensitivity | 0.59719521 |
81 | MP0003436_decreased_susceptibility_to | 0.58192111 |
82 | MP0006035_abnormal_mitochondrial_morpho | 0.58143357 |
83 | MP0005671_abnormal_response_to | 0.57533351 |
84 | MP0009053_abnormal_anal_canal | 0.57107960 |
85 | MP0003329_amyloid_beta_deposits | 0.57016624 |
86 | MP0000639_abnormal_adrenal_gland | 0.55310164 |
87 | MP0002420_abnormal_adaptive_immunity | 0.55234971 |
88 | MP0001819_abnormal_immune_cell | 0.54904439 |
89 | MP0002928_abnormal_bile_duct | 0.53925627 |
90 | MP0003724_increased_susceptibility_to | 0.52748250 |
91 | MP0005448_abnormal_energy_balance | 0.51058507 |
92 | MP0005164_abnormal_response_to | 0.51021705 |
93 | MP0003638_abnormal_response/metabolism_ | 0.49708349 |
94 | MP0009333_abnormal_splenocyte_physiolog | 0.49414086 |
95 | MP0005395_other_phenotype | 0.47512789 |
96 | MP0008873_increased_physiological_sensi | 0.46828645 |
97 | MP0008874_decreased_physiological_sensi | 0.46733142 |
98 | MP0001853_heart_inflammation | 0.43272578 |
99 | MP0003075_altered_response_to | 0.43237510 |
100 | MP0005166_decreased_susceptibility_to | 0.41957284 |
101 | MP0004782_abnormal_surfactant_physiolog | 0.41787998 |
102 | MP0003718_maternal_effect | 0.40401028 |
103 | MP0002822_catalepsy | 0.40262985 |
104 | MP0001845_abnormal_inflammatory_respons | 0.40157248 |
105 | MP0003953_abnormal_hormone_level | 0.40033305 |
106 | MP0006082_CNS_inflammation | 0.38792392 |
107 | MP0004381_abnormal_hair_follicle | 0.37825238 |
108 | MP0009672_abnormal_birth_weight | 0.36544654 |
109 | MP0005058_abnormal_lysosome_morphology | 0.36377987 |
110 | MP0005666_abnormal_adipose_tissue | 0.35755226 |
111 | MP0008872_abnormal_physiological_respon | 0.34927870 |
112 | MP0002837_dystrophic_cardiac_calcinosis | 0.34761004 |
113 | MP0002168_other_aberrant_phenotype | 0.34275431 |
114 | MP0000249_abnormal_blood_vessel | 0.33709170 |
115 | MP0000230_abnormal_systemic_arterial | 0.32800791 |
116 | MP0009115_abnormal_fat_cell | 0.32627700 |
117 | MP0004043_abnormal_pH_regulation | 0.31156969 |
118 | MP0002970_abnormal_white_adipose | 0.30724719 |
119 | MP0001765_abnormal_ion_homeostasis | 0.29882511 |
120 | MP0002796_impaired_skin_barrier | 0.29664086 |
121 | MP0001243_abnormal_dermal_layer | 0.28789379 |
122 | MP0002135_abnormal_kidney_morphology | 0.27699769 |
123 | MP0000579_abnormal_nail_morphology | 0.27371958 |
124 | MP0004883_abnormal_blood_vessel | 0.27154223 |
125 | MP0005248_abnormal_Harderian_gland | 0.26570505 |
126 | MP0001881_abnormal_mammary_gland | 0.25654955 |
127 | MP0009785_altered_susceptibility_to | 0.25532617 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 7.38660856 |
2 | Deep venous thrombosis (HP:0002625) | 7.13130947 |
3 | Intrahepatic cholestasis (HP:0001406) | 7.12767205 |
4 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 6.56772047 |
5 | Prolonged partial thromboplastin time (HP:0003645) | 6.33808262 |
6 | Hypobetalipoproteinemia (HP:0003563) | 6.30954136 |
7 | Xanthomatosis (HP:0000991) | 6.12924300 |
8 | Hyperlipoproteinemia (HP:0010980) | 5.41061281 |
9 | Complement deficiency (HP:0004431) | 5.11996547 |
10 | Joint hemorrhage (HP:0005261) | 4.74998072 |
11 | Hypolipoproteinemia (HP:0010981) | 4.62875193 |
12 | Hyperammonemia (HP:0001987) | 4.62296945 |
13 | Hyperglycinemia (HP:0002154) | 4.44352074 |
14 | Ketosis (HP:0001946) | 4.33418713 |
15 | Epidermoid cyst (HP:0200040) | 4.33174068 |
16 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 4.32401679 |
17 | Abnormality of the common coagulation pathway (HP:0010990) | 4.31274552 |
18 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 4.28939204 |
19 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 4.22859060 |
20 | Abnormality of methionine metabolism (HP:0010901) | 4.22725718 |
21 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 4.22657019 |
22 | Hyperglycinuria (HP:0003108) | 4.10949169 |
23 | Fat malabsorption (HP:0002630) | 4.04024843 |
24 | Abnormality of glycine metabolism (HP:0010895) | 4.03633089 |
25 | Abnormality of serine family amino acid metabolism (HP:0010894) | 4.03633089 |
26 | Hypoalphalipoproteinemia (HP:0003233) | 3.96644841 |
27 | Abnormality of pyrimidine metabolism (HP:0004353) | 3.88887514 |
28 | Hypoglycemic coma (HP:0001325) | 3.80595057 |
29 | Nephritis (HP:0000123) | 3.74321033 |
30 | Abnormality of complement system (HP:0005339) | 3.74163017 |
31 | Abnormality of the intrinsic pathway (HP:0010989) | 3.64517895 |
32 | Conjugated hyperbilirubinemia (HP:0002908) | 3.63450270 |
33 | Hypercholesterolemia (HP:0003124) | 3.48049322 |
34 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.47341642 |
35 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.40058523 |
36 | Hyperbilirubinemia (HP:0002904) | 3.33926100 |
37 | Delayed CNS myelination (HP:0002188) | 3.23465264 |
38 | Abnormality of nucleobase metabolism (HP:0010932) | 3.21875203 |
39 | Purpura (HP:0000979) | 3.18719533 |
40 | Ketoacidosis (HP:0001993) | 3.13391552 |
41 | Abnormality of serum amino acid levels (HP:0003112) | 3.10270782 |
42 | Steatorrhea (HP:0002570) | 3.07195734 |
43 | Hepatocellular carcinoma (HP:0001402) | 2.97074212 |
44 | Myocardial infarction (HP:0001658) | 2.93239659 |
45 | Spontaneous abortion (HP:0005268) | 2.88773935 |
46 | Pulmonary embolism (HP:0002204) | 2.88657136 |
47 | Abnormality of purine metabolism (HP:0004352) | 2.88369048 |
48 | Metabolic acidosis (HP:0001942) | 2.84287498 |
49 | Hypochromic microcytic anemia (HP:0004840) | 2.83493752 |
50 | Gout (HP:0001997) | 2.77296164 |
51 | Systemic lupus erythematosus (HP:0002725) | 2.71351781 |
52 | Dicarboxylic aciduria (HP:0003215) | 2.69207806 |
53 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.69207806 |
54 | Vascular calcification (HP:0004934) | 2.69006660 |
55 | Lethargy (HP:0001254) | 2.65764269 |
56 | Skin nodule (HP:0200036) | 2.61848201 |
57 | Spastic diplegia (HP:0001264) | 2.48838411 |
58 | Acanthocytosis (HP:0001927) | 2.47896819 |
59 | Mitral stenosis (HP:0001718) | 2.47875407 |
60 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.44478455 |
61 | Cerebral edema (HP:0002181) | 2.42795135 |
62 | Neonatal onset (HP:0003623) | 2.42156756 |
63 | Irritability (HP:0000737) | 2.39205623 |
64 | Hypoglycemic seizures (HP:0002173) | 2.38700991 |
65 | Glomerulonephritis (HP:0000099) | 2.37706244 |
66 | Epistaxis (HP:0000421) | 2.37575693 |
67 | Cardiovascular calcification (HP:0011915) | 2.37375185 |
68 | Abnormal gallbladder morphology (HP:0012437) | 2.35128941 |
69 | Gangrene (HP:0100758) | 2.31187069 |
70 | Malnutrition (HP:0004395) | 2.30972647 |
71 | Generalized aminoaciduria (HP:0002909) | 2.30728035 |
72 | Cholelithiasis (HP:0001081) | 2.29209906 |
73 | Amyloidosis (HP:0011034) | 2.24844092 |
74 | Gingival bleeding (HP:0000225) | 2.22527065 |
75 | Cholecystitis (HP:0001082) | 2.21279928 |
76 | Abnormal gallbladder physiology (HP:0012438) | 2.21279928 |
77 | Orchitis (HP:0100796) | 2.20225891 |
78 | Sensorimotor neuropathy (HP:0007141) | 2.18321079 |
79 | Late onset (HP:0003584) | 2.17869438 |
80 | Pancreatitis (HP:0001733) | 2.17047238 |
81 | Vomiting (HP:0002013) | 2.16553331 |
82 | Joint swelling (HP:0001386) | 2.16250862 |
83 | Esophageal varix (HP:0002040) | 2.14234541 |
84 | Myositis (HP:0100614) | 2.14058489 |
85 | Enlarged kidneys (HP:0000105) | 2.13528606 |
86 | Retrobulbar optic neuritis (HP:0100654) | 2.13032984 |
87 | Optic neuritis (HP:0100653) | 2.13032984 |
88 | Menorrhagia (HP:0000132) | 2.12810505 |
89 | Thrombophlebitis (HP:0004418) | 2.12460799 |
90 | Brushfield spots (HP:0001088) | 2.09694170 |
91 | Alkalosis (HP:0001948) | 2.08565809 |
92 | Meningitis (HP:0001287) | 2.04447820 |
93 | Opisthotonus (HP:0002179) | 2.03038099 |
94 | Cerebral palsy (HP:0100021) | 2.03032886 |
95 | Rickets (HP:0002748) | 2.00219502 |
96 | Increased serum ferritin (HP:0003281) | 2.00084570 |
97 | Abnormality of vitamin metabolism (HP:0100508) | 1.99101117 |
98 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 1.98986277 |
99 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 1.98986277 |
100 | Abnormality of polysaccharide metabolism (HP:0011012) | 1.98986277 |
101 | Mucopolysacchariduria (HP:0008155) | 1.98755867 |
102 | Urinary glycosaminoglycan excretion (HP:0003541) | 1.98755867 |
103 | Vacuolated lymphocytes (HP:0001922) | 1.98288682 |
104 | Neonatal hypoglycemia (HP:0001998) | 1.97802754 |
105 | Hydroxyprolinuria (HP:0003080) | 1.97456135 |
106 | Abnormality of proline metabolism (HP:0010907) | 1.97456135 |
107 | Proximal tubulopathy (HP:0000114) | 1.96981682 |
108 | Hemorrhage of the eye (HP:0011885) | 1.95983136 |
109 | Poikilocytosis (HP:0004447) | 1.95264166 |
110 | Abnormality of the gallbladder (HP:0005264) | 1.94212200 |
111 | Abnormality of urine glucose concentration (HP:0011016) | 1.93811733 |
112 | Abnormality of iron homeostasis (HP:0011031) | 1.92823441 |
113 | Abnormal enzyme/coenzyme activity (HP:0012379) | 1.90893971 |
114 | Renal cortical cysts (HP:0000803) | 1.90810644 |
115 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.90348021 |
116 | Increased purine levels (HP:0004368) | 1.90143373 |
117 | Hyperuricemia (HP:0002149) | 1.90143373 |
118 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.89615246 |
119 | Abnormal cartilage morphology (HP:0002763) | 1.88187480 |
120 | Elevated hepatic transaminases (HP:0002910) | 1.88091859 |
121 | Hypophosphatemic rickets (HP:0004912) | 1.87213429 |
122 | Glycosuria (HP:0003076) | 1.81392692 |
123 | Anorexia (HP:0002039) | 1.77235374 |
124 | Fair hair (HP:0002286) | 1.76738777 |
125 | Dysostosis multiplex (HP:0000943) | 1.74369282 |
126 | Abnormality of the prostate (HP:0008775) | 1.73697893 |
127 | Pulmonary infiltrates (HP:0002113) | 1.71579300 |
128 | Hypophosphatemia (HP:0002148) | 1.69812402 |
129 | Chronic obstructive pulmonary disease (HP:0006510) | 1.68602355 |
130 | Obstructive lung disease (HP:0006536) | 1.68602355 |
131 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.67172219 |
132 | Prolonged bleeding time (HP:0003010) | 1.66926307 |
133 | Increased cerebral lipofuscin (HP:0011813) | 1.65758094 |
134 | Abnormality of alkaline phosphatase activity (HP:0004379) | 1.65739677 |
135 | Abnormal platelet function (HP:0011869) | 1.65062793 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BCKDK | 7.22841483 |
2 | FGFR4 | 4.56508037 |
3 | ERN1 | 4.53497232 |
4 | SIK1 | 4.50527578 |
5 | TAOK3 | 3.09501647 |
6 | ACVR1B | 2.78344307 |
7 | INSRR | 2.67645876 |
8 | ERBB4 | 2.59462410 |
9 | RIPK4 | 2.29089693 |
10 | PKN2 | 2.21247896 |
11 | FLT3 | 2.10619557 |
12 | MAP2K4 | 2.08723799 |
13 | TNK2 | 1.96631913 |
14 | MST1R | 1.95674701 |
15 | TYK2 | 1.94252791 |
16 | MAPK11 | 1.89248358 |
17 | PIK3CG | 1.80543930 |
18 | TRIB3 | 1.78605823 |
19 | TXK | 1.55732964 |
20 | ABL2 | 1.46166229 |
21 | MATK | 1.44959204 |
22 | GRK6 | 1.43699268 |
23 | PTK6 | 1.41429954 |
24 | NEK9 | 1.39652238 |
25 | TBK1 | 1.39328078 |
26 | KDR | 1.38553458 |
27 | MAP3K14 | 1.34856027 |
28 | DAPK2 | 1.29259983 |
29 | JAK2 | 1.27210897 |
30 | MAP2K3 | 1.24745205 |
31 | MAP3K7 | 1.23415292 |
32 | LATS1 | 1.19762132 |
33 | IRAK4 | 1.18543382 |
34 | JAK1 | 1.15305974 |
35 | FRK | 1.14629021 |
36 | AKT3 | 1.11802471 |
37 | PRKAA2 | 1.07766135 |
38 | MAP3K10 | 1.07646138 |
39 | FGFR2 | 1.07368972 |
40 | TEC | 1.06249788 |
41 | PINK1 | 1.05783450 |
42 | MAP4K2 | 1.03590667 |
43 | BMPR2 | 1.02657999 |
44 | FES | 0.99808126 |
45 | MAPK4 | 0.99166207 |
46 | CSF1R | 0.96234527 |
47 | IRAK1 | 0.95358288 |
48 | MAP4K1 | 0.95247126 |
49 | IRAK3 | 0.91128044 |
50 | PDK2 | 0.88501827 |
51 | LCK | 0.88332120 |
52 | PRKCZ | 0.87876050 |
53 | EPHB1 | 0.86144680 |
54 | MAP3K3 | 0.85439981 |
55 | CSK | 0.85294333 |
56 | STK38L | 0.82525846 |
57 | ERBB2 | 0.82163698 |
58 | PIK3CA | 0.81542228 |
59 | MAP3K11 | 0.79036706 |
60 | MAPK12 | 0.78699350 |
61 | MAPK15 | 0.77630834 |
62 | CDK6 | 0.76169985 |
63 | IKBKE | 0.74552470 |
64 | OXSR1 | 0.74522984 |
65 | DYRK1B | 0.74013191 |
66 | GRK7 | 0.71406818 |
67 | MAP3K2 | 0.70131755 |
68 | MAPKAPK3 | 0.70117700 |
69 | PRKACG | 0.69736258 |
70 | TGFBR2 | 0.68980484 |
71 | TIE1 | 0.68883757 |
72 | MAP2K6 | 0.68373989 |
73 | DAPK1 | 0.68317708 |
74 | HCK | 0.67065120 |
75 | PRKG2 | 0.66942997 |
76 | MAP3K13 | 0.66383817 |
77 | TESK2 | 0.66111547 |
78 | GSK3A | 0.64767619 |
79 | FER | 0.64432555 |
80 | KIT | 0.63674458 |
81 | SGK3 | 0.63594539 |
82 | PIM2 | 0.63572169 |
83 | PRKAA1 | 0.61564089 |
84 | PRKCQ | 0.60978308 |
85 | MAP3K1 | 0.60624795 |
86 | FGR | 0.59717826 |
87 | LMTK2 | 0.59178289 |
88 | ADRBK2 | 0.58782246 |
89 | EPHA3 | 0.57873403 |
90 | MET | 0.56392141 |
91 | CAMK2G | 0.55963215 |
92 | CAMK1D | 0.55682575 |
93 | PDPK1 | 0.55609277 |
94 | TLK1 | 0.53969892 |
95 | FGFR3 | 0.53323451 |
96 | MAP2K2 | 0.50664064 |
97 | NLK | 0.50439942 |
98 | MAPK7 | 0.49588694 |
99 | CSNK1G1 | 0.49310577 |
100 | CHUK | 0.49160495 |
101 | NUAK1 | 0.48513200 |
102 | RIPK1 | 0.48479419 |
103 | MAP3K5 | 0.47199010 |
104 | CDK4 | 0.46855743 |
105 | GRK1 | 0.46185791 |
106 | SGK2 | 0.46162810 |
107 | BLK | 0.45733590 |
108 | BTK | 0.44546386 |
109 | TAOK2 | 0.44070818 |
110 | PTK2 | 0.42382737 |
111 | PDK1 | 0.41570213 |
112 | PRKCA | 0.40819355 |
113 | IGF1R | 0.40269859 |
114 | PRPF4B | 0.39769020 |
115 | MAPK3 | 0.39320835 |
116 | CDC42BPA | 0.38723139 |
117 | PRKACA | 0.38686056 |
118 | SGK223 | 0.35099047 |
119 | SGK494 | 0.35099047 |
120 | ITK | 0.33833227 |
121 | ZAK | 0.33151292 |
122 | EGFR | 0.31537437 |
123 | LYN | 0.31248138 |
124 | CAMK4 | 0.30622842 |
125 | MAP3K6 | 0.30134314 |
126 | ZAP70 | 0.29894364 |
127 | CSNK1G3 | 0.29287697 |
128 | PDK4 | 0.29015555 |
129 | PDK3 | 0.29015555 |
130 | PRKCG | 0.28502874 |
131 | RET | 0.28416157 |
132 | WNK3 | 0.27977886 |
133 | ABL1 | 0.27758256 |
134 | CSNK1G2 | 0.27290234 |
135 | JAK3 | 0.27089990 |
136 | MTOR | 0.26622214 |
137 | MAP2K1 | 0.26620275 |
138 | PKN1 | 0.26321643 |
139 | IKBKB | 0.24960184 |
140 | SYK | 0.24068022 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 4.48517284 |
2 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 3.44132671 |
3 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.42871631 |
4 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.41452206 |
5 | Arginine biosynthesis_Homo sapiens_hsa00220 | 3.02845191 |
6 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.68423361 |
7 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.67746362 |
8 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 2.67735290 |
9 | * Tryptophan metabolism_Homo sapiens_hsa00380 | 2.61717055 |
10 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.56138316 |
11 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.48978274 |
12 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.43787287 |
13 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.34650979 |
14 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.20018112 |
15 | Peroxisome_Homo sapiens_hsa04146 | 2.14892163 |
16 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.11914529 |
17 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.97847525 |
18 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.93272858 |
19 | Histidine metabolism_Homo sapiens_hsa00340 | 1.91419389 |
20 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.90856954 |
21 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.90270482 |
22 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.84113115 |
23 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.79563134 |
24 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.78948052 |
25 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.73583512 |
26 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.72146548 |
27 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.72116753 |
28 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.71732992 |
29 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.69184949 |
30 | Retinol metabolism_Homo sapiens_hsa00830 | 1.68277995 |
31 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.65205620 |
32 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.60638853 |
33 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.58356349 |
34 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.55572798 |
35 | Bile secretion_Homo sapiens_hsa04976 | 1.48000353 |
36 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.43495631 |
37 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.41489968 |
38 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.40976118 |
39 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.36816451 |
40 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.31962900 |
41 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.29644937 |
42 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.29540568 |
43 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.25298077 |
44 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.21025101 |
45 | ABC transporters_Homo sapiens_hsa02010 | 1.18058404 |
46 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.16983056 |
47 | Carbon metabolism_Homo sapiens_hsa01200 | 1.15646714 |
48 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.15579028 |
49 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.08305954 |
50 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.07739494 |
51 | Other glycan degradation_Homo sapiens_hsa00511 | 1.04981869 |
52 | Sulfur relay system_Homo sapiens_hsa04122 | 0.99177832 |
53 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.98826430 |
54 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.98654447 |
55 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.97890401 |
56 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.91156560 |
57 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.89719610 |
58 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.89492147 |
59 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.88447878 |
60 | Lysine degradation_Homo sapiens_hsa00310 | 0.83942432 |
61 | Asthma_Homo sapiens_hsa05310 | 0.82117344 |
62 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.79066947 |
63 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.74647198 |
64 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.71504852 |
65 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.70365211 |
66 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.67137434 |
67 | Allograft rejection_Homo sapiens_hsa05330 | 0.65517530 |
68 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.62325032 |
69 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.54091218 |
70 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.53690200 |
71 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.51678561 |
72 | * Metabolic pathways_Homo sapiens_hsa01100 | 0.46299995 |
73 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.45494332 |
74 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.41136032 |
75 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.38505292 |
76 | Leishmaniasis_Homo sapiens_hsa05140 | 0.37818852 |
77 | Mineral absorption_Homo sapiens_hsa04978 | 0.36608162 |
78 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.31991759 |
79 | Prion diseases_Homo sapiens_hsa05020 | 0.29902178 |
80 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.26210239 |
81 | Galactose metabolism_Homo sapiens_hsa00052 | 0.25658238 |
82 | Insulin resistance_Homo sapiens_hsa04931 | 0.22453618 |
83 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.21513424 |
84 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.20357806 |
85 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.16215484 |
86 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.15655862 |
87 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.15271127 |
88 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.14771667 |
89 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.12157646 |
90 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.12039874 |
91 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.11396100 |
92 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.10248763 |
93 | Tuberculosis_Homo sapiens_hsa05152 | 0.09065048 |
94 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.06483103 |
95 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.05937565 |
96 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.03455861 |
97 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.00807365 |
98 | Lysosome_Homo sapiens_hsa04142 | -0.2512350 |
99 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | -0.2497635 |
100 | Pertussis_Homo sapiens_hsa05133 | -0.2315087 |
101 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | -0.2167442 |
102 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | -0.2041575 |
103 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | -0.1991824 |
104 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | -0.1981390 |
105 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | -0.1709468 |
106 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | -0.1679106 |
107 | Hepatitis C_Homo sapiens_hsa05160 | -0.1622787 |
108 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | -0.1614008 |
109 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | -0.1596583 |
110 | Renin-angiotensin system_Homo sapiens_hsa04614 | -0.1595146 |
111 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | -0.1521805 |
112 | African trypanosomiasis_Homo sapiens_hsa05143 | -0.1380429 |
113 | Regulation of autophagy_Homo sapiens_hsa04140 | -0.1256841 |
114 | Insulin signaling pathway_Homo sapiens_hsa04910 | -0.1248620 |
115 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | -0.1180353 |
116 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | -0.1034428 |
117 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | -0.0751743 |
118 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | -0.0302131 |
119 | AMPK signaling pathway_Homo sapiens_hsa04152 | -0.0074460 |