

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | L-phenylalanine catabolic process (GO:0006559) | 7.56384074 |
| 2 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 7.56384074 |
| 3 | epoxygenase P450 pathway (GO:0019373) | 7.42899180 |
| 4 | L-phenylalanine metabolic process (GO:0006558) | 7.27380900 |
| 5 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 7.27380900 |
| 6 | omega-hydroxylase P450 pathway (GO:0097267) | 7.05158683 |
| 7 | aromatic amino acid family catabolic process (GO:0009074) | 6.75990593 |
| 8 | tryptophan catabolic process (GO:0006569) | 6.07926640 |
| 9 | indole-containing compound catabolic process (GO:0042436) | 6.07926640 |
| 10 | indolalkylamine catabolic process (GO:0046218) | 6.07926640 |
| 11 | oxidative demethylation (GO:0070989) | 6.06838169 |
| 12 | glyoxylate metabolic process (GO:0046487) | 6.06638472 |
| 13 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 6.02930053 |
| 14 | kynurenine metabolic process (GO:0070189) | 5.90426717 |
| 15 | drug metabolic process (GO:0017144) | 5.84435836 |
| 16 | bile acid biosynthetic process (GO:0006699) | 5.75718978 |
| 17 | tryptophan metabolic process (GO:0006568) | 5.73452307 |
| 18 | cysteine metabolic process (GO:0006534) | 5.65193419 |
| 19 | negative regulation of fibrinolysis (GO:0051918) | 5.43246951 |
| 20 | urea metabolic process (GO:0019627) | 5.41334186 |
| 21 | urea cycle (GO:0000050) | 5.41334186 |
| 22 | phenylpropanoid metabolic process (GO:0009698) | 5.37552715 |
| 23 | alpha-linolenic acid metabolic process (GO:0036109) | 5.34266035 |
| 24 | sulfur amino acid catabolic process (GO:0000098) | 5.33233585 |
| 25 | high-density lipoprotein particle remodeling (GO:0034375) | 5.31295959 |
| 26 | regulation of plasminogen activation (GO:0010755) | 5.29831833 |
| 27 | serine family amino acid catabolic process (GO:0009071) | 5.23223892 |
| 28 | regulation of fibrinolysis (GO:0051917) | 5.21539303 |
| 29 | peptidyl-glutamic acid carboxylation (GO:0017187) | 5.20079161 |
| 30 | protein carboxylation (GO:0018214) | 5.20079161 |
| 31 | negative regulation of blood coagulation (GO:0030195) | 5.15528867 |
| 32 | negative regulation of hemostasis (GO:1900047) | 5.15528867 |
| 33 | regulation of protein activation cascade (GO:2000257) | 5.12809463 |
| 34 | complement activation, alternative pathway (GO:0006957) | 5.09091040 |
| 35 | lysine catabolic process (GO:0006554) | 5.04172388 |
| 36 | lysine metabolic process (GO:0006553) | 5.04172388 |
| 37 | nitrogen cycle metabolic process (GO:0071941) | 4.99140198 |
| 38 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 4.98033940 |
| 39 | homocysteine metabolic process (GO:0050667) | 4.94413555 |
| 40 | aromatic amino acid family metabolic process (GO:0009072) | 4.92147599 |
| 41 | bile acid metabolic process (GO:0008206) | 4.91650540 |
| 42 | regulation of complement activation (GO:0030449) | 4.77570997 |
| 43 | S-adenosylmethionine metabolic process (GO:0046500) | 4.71960990 |
| 44 | negative regulation of coagulation (GO:0050819) | 4.71680860 |
| 45 | alpha-amino acid catabolic process (GO:1901606) | 4.68970327 |
| 46 | reverse cholesterol transport (GO:0043691) | 4.68603204 |
| 47 | amino-acid betaine metabolic process (GO:0006577) | 4.67507743 |
| 48 | negative regulation of lipase activity (GO:0060192) | 4.66027745 |
| 49 | daunorubicin metabolic process (GO:0044597) | 4.65568771 |
| 50 | polyketide metabolic process (GO:0030638) | 4.65568771 |
| 51 | doxorubicin metabolic process (GO:0044598) | 4.65568771 |
| 52 | regulation of cholesterol esterification (GO:0010872) | 4.64757853 |
| 53 | regulation of triglyceride catabolic process (GO:0010896) | 4.63974410 |
| 54 | tyrosine metabolic process (GO:0006570) | 4.63162730 |
| 55 | negative regulation of wound healing (GO:0061045) | 4.61040609 |
| 56 | protein-lipid complex remodeling (GO:0034368) | 4.56153827 |
| 57 | macromolecular complex remodeling (GO:0034367) | 4.56153827 |
| 58 | plasma lipoprotein particle remodeling (GO:0034369) | 4.56153827 |
| 59 | cellular ketone body metabolic process (GO:0046950) | 4.54485460 |
| 60 | triglyceride homeostasis (GO:0070328) | 4.44858847 |
| 61 | acylglycerol homeostasis (GO:0055090) | 4.44858847 |
| 62 | glycine metabolic process (GO:0006544) | 4.43963793 |
| 63 | negative regulation of sterol transport (GO:0032372) | 4.41943311 |
| 64 | negative regulation of cholesterol transport (GO:0032375) | 4.41943311 |
| 65 | fat-soluble vitamin biosynthetic process (GO:0042362) | 4.40715017 |
| 66 | serine family amino acid metabolic process (GO:0009069) | 4.37654214 |
| 67 | ethanol metabolic process (GO:0006067) | 4.37080932 |
| 68 | cellular amino acid catabolic process (GO:0009063) | 4.36292068 |
| 69 | alkaloid metabolic process (GO:0009820) | 4.34907531 |
| 70 | phospholipid efflux (GO:0033700) | 4.34512954 |
| 71 | coenzyme catabolic process (GO:0009109) | 4.33909785 |
| 72 | indolalkylamine metabolic process (GO:0006586) | 4.30614504 |
| 73 | cellular modified amino acid catabolic process (GO:0042219) | 4.30558465 |
| 74 | positive regulation of hemostasis (GO:1900048) | 4.28978761 |
| 75 | positive regulation of blood coagulation (GO:0030194) | 4.28978761 |
| 76 | protein activation cascade (GO:0072376) | 4.28402233 |
| 77 | glutamate metabolic process (GO:0006536) | 4.28278328 |
| 78 | plasma lipoprotein particle clearance (GO:0034381) | 4.21880933 |
| 79 | bile acid and bile salt transport (GO:0015721) | 4.21220192 |
| 80 | serine family amino acid biosynthetic process (GO:0009070) | 4.19775398 |
| 81 | drug catabolic process (GO:0042737) | 4.19176516 |
| 82 | cellular biogenic amine catabolic process (GO:0042402) | 4.18988953 |
| 83 | amine catabolic process (GO:0009310) | 4.18988953 |
| 84 | regulation of humoral immune response (GO:0002920) | 4.16709211 |
| 85 | cellular glucuronidation (GO:0052695) | 4.15493647 |
| 86 | heme transport (GO:0015886) | 4.14791479 |
| 87 | aminoglycoside antibiotic metabolic process (GO:0030647) | 4.12396983 |
| 88 | hormone catabolic process (GO:0042447) | 4.11615114 |
| 89 | benzene-containing compound metabolic process (GO:0042537) | 4.11419259 |
| 90 | imidazole-containing compound metabolic process (GO:0052803) | 4.07025215 |
| 91 | acute-phase response (GO:0006953) | 4.06918068 |
| 92 | ethanol oxidation (GO:0006069) | 4.05469153 |
| 93 | positive regulation of coagulation (GO:0050820) | 4.00766912 |
| 94 | cholesterol efflux (GO:0033344) | 4.00058680 |
| 95 | dicarboxylic acid biosynthetic process (GO:0043650) | 3.99740621 |
| 96 | flavonoid metabolic process (GO:0009812) | 3.96947468 |
| 97 | short-chain fatty acid metabolic process (GO:0046459) | 3.96420432 |
| 98 | response to mercury ion (GO:0046689) | 3.96099539 |
| 99 | aldehyde catabolic process (GO:0046185) | 3.95183844 |
| 100 | ketone body metabolic process (GO:1902224) | 3.92998132 |
| 101 | negative regulation of protein activation cascade (GO:2000258) | 3.91094284 |
| 102 | urate metabolic process (GO:0046415) | 3.89852754 |
| 103 | drug transmembrane transport (GO:0006855) | 3.88279611 |
| 104 | arginine metabolic process (GO:0006525) | 3.88144623 |
| 105 | fibrinolysis (GO:0042730) | 3.87137316 |
| 106 | negative regulation of fatty acid biosynthetic process (GO:0045717) | 3.84862299 |
| 107 | plasma lipoprotein particle assembly (GO:0034377) | 3.84795467 |
| 108 | primary alcohol catabolic process (GO:0034310) | 3.84560555 |
| 109 | aspartate family amino acid catabolic process (GO:0009068) | 3.83277564 |
| 110 | carboxylic acid catabolic process (GO:0046395) | 3.83143250 |
| 111 | organic acid catabolic process (GO:0016054) | 3.83143250 |
| 112 | regulation of lipoprotein particle clearance (GO:0010984) | 3.80951454 |
| 113 | positive regulation of heterotypic cell-cell adhesion (GO:0034116) | 3.75064253 |
| 114 | low-density lipoprotein particle remodeling (GO:0034374) | 3.74928847 |
| 115 | acetyl-CoA metabolic process (GO:0006084) | 3.74725921 |
| 116 | regulation of bile acid biosynthetic process (GO:0070857) | 3.73466385 |
| 117 | glucuronate metabolic process (GO:0019585) | 3.72930426 |
| 118 | uronic acid metabolic process (GO:0006063) | 3.72930426 |
| 119 | phospholipid homeostasis (GO:0055091) | 3.71050349 |
| 120 | cofactor catabolic process (GO:0051187) | 3.69337308 |
| 121 | cholesterol homeostasis (GO:0042632) | 3.68893946 |
| 122 | positive regulation of lipoprotein lipase activity (GO:0051006) | 3.67784814 |
| 123 | positive regulation of triglyceride lipase activity (GO:0061365) | 3.67784814 |
| 124 | regulation of cholesterol homeostasis (GO:2000188) | 3.67604496 |
| 125 | intestinal cholesterol absorption (GO:0030299) | 3.66357838 |
| 126 | blood coagulation, intrinsic pathway (GO:0007597) | 3.65284881 |
| 127 | exogenous drug catabolic process (GO:0042738) | 3.64691073 |
| 128 | sterol homeostasis (GO:0055092) | 3.64093772 |
| 129 | L-methionine salvage (GO:0071267) | 3.63163282 |
| 130 | L-methionine biosynthetic process (GO:0071265) | 3.63163282 |
| 131 | amino acid salvage (GO:0043102) | 3.63163282 |
| 132 | xenobiotic metabolic process (GO:0006805) | 3.62076909 |
| 133 | 2-oxoglutarate metabolic process (GO:0006103) | 3.60501375 |
| 134 | positive regulation of lipid catabolic process (GO:0050996) | 3.59041878 |
| 135 | complement activation, classical pathway (GO:0006958) | 3.57516339 |
| 136 | monocarboxylic acid catabolic process (GO:0072329) | 3.54059779 |
| 137 | very-low-density lipoprotein particle assembly (GO:0034379) | 3.54038154 |
| 138 | complement activation (GO:0006956) | 3.53293158 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * RXR_22158963_ChIP-Seq_LIVER_Mouse | 8.27582856 |
| 2 | * PPARA_22158963_ChIP-Seq_LIVER_Mouse | 7.14341167 |
| 3 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 6.74640105 |
| 4 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 6.43404932 |
| 5 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 5.18617642 |
| 6 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 4.96092881 |
| 7 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 4.95871362 |
| 8 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 3.98776962 |
| 9 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 3.88959282 |
| 10 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 2.16177255 |
| 11 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.12451547 |
| 12 | * TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 2.04696635 |
| 13 | * ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 11.7903355 |
| 14 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.77688325 |
| 15 | * FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.65221083 |
| 16 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.65006116 |
| 17 | * HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.45652028 |
| 18 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.43628618 |
| 19 | GATA1_22025678_ChIP-Seq_K562_Human | 1.39519133 |
| 20 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.28650742 |
| 21 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.25712638 |
| 22 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 1.17680167 |
| 23 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.16562915 |
| 24 | * SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.10462379 |
| 25 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.09011484 |
| 26 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.08222147 |
| 27 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.04231965 |
| 28 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.00120428 |
| 29 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.98386877 |
| 30 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.97886773 |
| 31 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.97103622 |
| 32 | * GATA4_25053715_ChIP-Seq_YYC3_Human | 0.96006116 |
| 33 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 0.94367501 |
| 34 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.90800181 |
| 35 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.90207025 |
| 36 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 0.88123395 |
| 37 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.86967830 |
| 38 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.85994439 |
| 39 | * HNFA_21074721_ChIP-Seq_CACO-2_Human | 0.85939861 |
| 40 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.84476016 |
| 41 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.80689774 |
| 42 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.80579815 |
| 43 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.78840292 |
| 44 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.78727725 |
| 45 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.77803621 |
| 46 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.76867199 |
| 47 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.76107214 |
| 48 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.76026841 |
| 49 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.75421144 |
| 50 | SOX2_21211035_ChIP-Seq_LN229_Human | 0.74456594 |
| 51 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.73959947 |
| 52 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.73537382 |
| 53 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 0.73393476 |
| 54 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.73166246 |
| 55 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.73155361 |
| 56 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.73110523 |
| 57 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.72708680 |
| 58 | * NFYA_21822215_ChIP-Seq_K562_Human | 0.70469069 |
| 59 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.69967038 |
| 60 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.68877601 |
| 61 | * SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.66914844 |
| 62 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.66172025 |
| 63 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.66027174 |
| 64 | EZH2_22144423_ChIP-Seq_EOC_Human | 0.65854546 |
| 65 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.65632726 |
| 66 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 0.65624914 |
| 67 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.65550673 |
| 68 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.65238632 |
| 69 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.64592745 |
| 70 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 0.64358583 |
| 71 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.63951513 |
| 72 | * FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.63905789 |
| 73 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.63539982 |
| 74 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.63247679 |
| 75 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.61534649 |
| 76 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.61015635 |
| 77 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.60725193 |
| 78 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.60691938 |
| 79 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.60478413 |
| 80 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.60278632 |
| 81 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 0.58862357 |
| 82 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 0.58699367 |
| 83 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.57363095 |
| 84 | * NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.57189415 |
| 85 | * NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.57189415 |
| 86 | CBX2_22325352_ChIP-Seq_293T-Rex_Human | 0.56891120 |
| 87 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.56732674 |
| 88 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.56732674 |
| 89 | * FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.55281488 |
| 90 | * GATA6_25053715_ChIP-Seq_YYC3_Human | 0.55058522 |
| 91 | AR_20517297_ChIP-Seq_VCAP_Human | 0.54541382 |
| 92 | RAC3_21632823_ChIP-Seq_H3396_Human | 0.54350140 |
| 93 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.54296770 |
| 94 | * FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.54278784 |
| 95 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.53345940 |
| 96 | ESET_19884257_ChIP-Seq_ESCs_Mouse | 0.53207906 |
| 97 | FOXA1_26743006_Chip-Seq_LNCaP-abl_Human | 0.52413489 |
| 98 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.52115435 |
| 99 | * MYC_19915707_ChIP-ChIP_AK7_Human | 0.51517896 |
| 100 | * PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.51392582 |
| 101 | ETV1_20927104_ChIP-Seq_GIST48_Human | 0.50634490 |
| 102 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 0.48839001 |
| 103 | GF1_26923725_Chip-Seq_HPCs_Mouse | 0.48403711 |
| 104 | * NFYB_21822215_ChIP-Seq_K562_Human | 0.48350356 |
| 105 | * CBP_21632823_ChIP-Seq_H3396_Human | 0.48027107 |
| 106 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.47976053 |
| 107 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.47954551 |
| 108 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.47700444 |
| 109 | GATA1_19941826_ChIP-Seq_K562_Human | 0.47561172 |
| 110 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.47402981 |
| 111 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.47360099 |
| 112 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.47266848 |
| 113 | STAT1_17558387_ChIP-Seq_HELA_Human | 0.47191306 |
| 114 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 0.46771761 |
| 115 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.45683288 |
| 116 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.45649352 |
| 117 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.45633304 |
| 118 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.45343445 |
| 119 | * PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.45201354 |
| 120 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.45019348 |
| 121 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.44928570 |
| 122 | * TAF2_19829295_ChIP-Seq_ESCs_Human | 0.44609196 |
| 123 | GATA2_19941826_ChIP-Seq_K562_Human | 0.44475425 |
| 124 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.44174186 |
| 125 | PPARG_20887899_ChIP-Seq_3T3-L1_Mouse | 0.43657324 |
| 126 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 0.41373610 |
| 127 | SOX2_20726797_ChIP-Seq_SW620_Human | 0.41070218 |
| 128 | CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.40325644 |
| 129 | GATA3_24758297_ChIP-Seq_MCF-7_Human | 0.38476245 |
| 130 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.38407592 |
| 131 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.37901796 |
| 132 | P63_20808887_ChIP-Seq_KERATINOCYTES_Human | 0.37761847 |
| 133 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 0.37569045 |
| 134 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 0.37569045 |
| 135 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.37251105 |
| 136 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.37210880 |
| 137 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.36677548 |
| 138 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.36518461 |
| 139 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.36372201 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002139_abnormal_hepatobiliary_system | 8.15273129 |
| 2 | MP0005360_urolithiasis | 7.61100820 |
| 3 | MP0005085_abnormal_gallbladder_physiolo | 6.29514706 |
| 4 | MP0005365_abnormal_bile_salt | 6.14442044 |
| 5 | MP0008875_abnormal_xenobiotic_pharmacok | 4.87862149 |
| 6 | MP0003806_abnormal_nucleotide_metabolis | 4.09623405 |
| 7 | MP0003252_abnormal_bile_duct | 3.89910048 |
| 8 | MP0010329_abnormal_lipoprotein_level | 3.41866796 |
| 9 | MP0005083_abnormal_biliary_tract | 3.40820820 |
| 10 | MP0009840_abnormal_foam_cell | 3.05681910 |
| 11 | MP0005332_abnormal_amino_acid | 2.97554315 |
| 12 | MP0003195_calcinosis | 2.95152224 |
| 13 | MP0001666_abnormal_nutrient_absorption | 2.94962008 |
| 14 | MP0004019_abnormal_vitamin_homeostasis | 2.36721762 |
| 15 | MP0002138_abnormal_hepatobiliary_system | 2.31303345 |
| 16 | MP0003191_abnormal_cellular_cholesterol | 2.28849924 |
| 17 | MP0000609_abnormal_liver_physiology | 2.07340919 |
| 18 | MP0002118_abnormal_lipid_homeostasis | 2.06403416 |
| 19 | MP0003868_abnormal_feces_composition | 1.95593172 |
| 20 | MP0005319_abnormal_enzyme/_coenzyme | 1.83431231 |
| 21 | MP0001764_abnormal_homeostasis | 1.62731853 |
| 22 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.56102425 |
| 23 | MP0009643_abnormal_urine_homeostasis | 1.49761765 |
| 24 | MP0005451_abnormal_body_composition | 1.40632511 |
| 25 | MP0009697_abnormal_copulation | 1.37815080 |
| 26 | MP0003186_abnormal_redox_activity | 1.31953827 |
| 27 | MP0003011_delayed_dark_adaptation | 1.23531177 |
| 28 | MP0003656_abnormal_erythrocyte_physiolo | 1.19730475 |
| 29 | MP0003705_abnormal_hypodermis_morpholog | 1.18557762 |
| 30 | MP0005084_abnormal_gallbladder_morpholo | 1.17507789 |
| 31 | MP0000598_abnormal_liver_morphology | 1.16329878 |
| 32 | MP0005636_abnormal_mineral_homeostasis | 1.13876861 |
| 33 | MP0005647_abnormal_sex_gland | 1.03524880 |
| 34 | MP0005220_abnormal_exocrine_pancreas | 1.02853401 |
| 35 | MP0003879_abnormal_hair_cell | 1.00351866 |
| 36 | MP0009764_decreased_sensitivity_to | 1.00065515 |
| 37 | MP0000604_amyloidosis | 0.98833838 |
| 38 | MP0009763_increased_sensitivity_to | 0.95499455 |
| 39 | MP0006036_abnormal_mitochondrial_physio | 0.94525267 |
| 40 | MP0010368_abnormal_lymphatic_system | 0.92500373 |
| 41 | MP0002254_reproductive_system_inflammat | 0.90220852 |
| 42 | MP0009642_abnormal_blood_homeostasis | 0.88239854 |
| 43 | MP0000566_synostosis | 0.88125805 |
| 44 | MP0008469_abnormal_protein_level | 0.87238447 |
| 45 | MP0005408_hypopigmentation | 0.85530262 |
| 46 | MP0005670_abnormal_white_adipose | 0.79767284 |
| 47 | MP0002078_abnormal_glucose_homeostasis | 0.79166482 |
| 48 | MP0001756_abnormal_urination | 0.77924989 |
| 49 | MP0002876_abnormal_thyroid_physiology | 0.76727666 |
| 50 | MP0001915_intracranial_hemorrhage | 0.76267037 |
| 51 | MP0005376_homeostasis/metabolism_phenot | 0.74695725 |
| 52 | MP0009765_abnormal_xenobiotic_induced | 0.74653532 |
| 53 | MP0005535_abnormal_body_temperature | 0.69225611 |
| 54 | MP0002971_abnormal_brown_adipose | 0.68231422 |
| 55 | MP0001661_extended_life_span | 0.68154972 |
| 56 | MP0004130_abnormal_muscle_cell | 0.67523007 |
| 57 | MP0005187_abnormal_penis_morphology | 0.66746657 |
| 58 | MP0004043_abnormal_pH_regulation | 0.66114372 |
| 59 | MP0005334_abnormal_fat_pad | 0.65575322 |
| 60 | MP0005023_abnormal_wound_healing | 0.65172849 |
| 61 | MP0002136_abnormal_kidney_physiology | 0.64887137 |
| 62 | MP0002928_abnormal_bile_duct | 0.62959671 |
| 63 | MP0002132_abnormal_respiratory_system | 0.62493994 |
| 64 | MP0003283_abnormal_digestive_organ | 0.61468578 |
| 65 | MP0005266_abnormal_metabolism | 0.61001150 |
| 66 | MP0006035_abnormal_mitochondrial_morpho | 0.59603747 |
| 67 | MP0009053_abnormal_anal_canal | 0.58193497 |
| 68 | MP0003329_amyloid_beta_deposits | 0.57935915 |
| 69 | MP0005448_abnormal_energy_balance | 0.55632369 |
| 70 | MP0002837_dystrophic_cardiac_calcinosis | 0.55348616 |
| 71 | MP0003690_abnormal_glial_cell | 0.55248233 |
| 72 | MP0003638_abnormal_response/metabolism_ | 0.52987762 |
| 73 | MP0000639_abnormal_adrenal_gland | 0.49580532 |
| 74 | MP0005395_other_phenotype | 0.49431081 |
| 75 | MP0005666_abnormal_adipose_tissue | 0.44848194 |
| 76 | MP0005464_abnormal_platelet_physiology | 0.43978825 |
| 77 | MP0003953_abnormal_hormone_level | 0.43829731 |
| 78 | MP0005164_abnormal_response_to | 0.43494332 |
| 79 | MP0001765_abnormal_ion_homeostasis | 0.43180285 |
| 80 | MP0009384_cardiac_valve_regurgitation | 0.40446842 |
| 81 | MP0004264_abnormal_extraembryonic_tissu | 0.40406175 |
| 82 | MP0002249_abnormal_larynx_morphology | 0.40166231 |
| 83 | MP0008873_increased_physiological_sensi | 0.39438555 |
| 84 | MP0002796_impaired_skin_barrier | 0.39205719 |
| 85 | MP0008874_decreased_physiological_sensi | 0.38776736 |
| 86 | MP0002089_abnormal_postnatal_growth/wei | 0.38743517 |
| 87 | MP0009672_abnormal_birth_weight | 0.38308592 |
| 88 | MP0002822_catalepsy | 0.38259984 |
| 89 | MP0005058_abnormal_lysosome_morphology | 0.38026228 |
| 90 | MP0003718_maternal_effect | 0.37815352 |
| 91 | MP0002168_other_aberrant_phenotype | 0.37742921 |
| 92 | MP0000230_abnormal_systemic_arterial | 0.37659175 |
| 93 | MP0002282_abnormal_trachea_morphology | 0.37553338 |
| 94 | MP0005166_decreased_susceptibility_to | 0.35344796 |
| 95 | MP0003075_altered_response_to | 0.34971857 |
| 96 | MP0003724_increased_susceptibility_to | 0.34932199 |
| 97 | MP0003699_abnormal_female_reproductive | 0.34752607 |
| 98 | MP0008872_abnormal_physiological_respon | 0.34052183 |
| 99 | MP0004883_abnormal_blood_vessel | 0.33664467 |
| 100 | MP0004782_abnormal_surfactant_physiolog | 0.33375588 |
| 101 | MP0000579_abnormal_nail_morphology | 0.31406423 |
| 102 | MP0010386_abnormal_urinary_bladder | 0.31159130 |
| 103 | MP0003632_abnormal_nervous_system | 0.30742150 |
| 104 | MP0003959_abnormal_lean_body | 0.30454835 |
| 105 | MP0002135_abnormal_kidney_morphology | 0.30201867 |
| 106 | MP0009115_abnormal_fat_cell | 0.29766610 |
| 107 | MP0003436_decreased_susceptibility_to | 0.29327419 |
| 108 | MP0002970_abnormal_white_adipose | 0.28753142 |
| 109 | MP0005197_abnormal_uvea_morphology | 0.28573841 |
| 110 | MP0003943_abnormal_hepatobiliary_system | 0.27943028 |
| 111 | MP0001845_abnormal_inflammatory_respons | 0.27649228 |
| 112 | MP0005248_abnormal_Harderian_gland | 0.27371116 |
| 113 | MP0010234_abnormal_vibrissa_follicle | 0.27077690 |
| 114 | MP0000249_abnormal_blood_vessel | 0.27062952 |
| 115 | MP0001944_abnormal_pancreas_morphology | 0.26427246 |
| 116 | MP0001243_abnormal_dermal_layer | 0.24449887 |
| 117 | MP0002269_muscular_atrophy | 0.24047465 |
| 118 | MP0000467_abnormal_esophagus_morphology | 0.22927049 |
| 119 | MP0000920_abnormal_myelination | 0.22713469 |
| 120 | MP0005377_hearing/vestibular/ear_phenot | 0.21711968 |
| 121 | MP0003878_abnormal_ear_physiology | 0.21711968 |
| 122 | MP0004142_abnormal_muscle_tone | 0.20230598 |
| 123 | MP0003890_abnormal_embryonic-extraembry | 0.19050126 |
| 124 | MP0001851_eye_inflammation | 0.18184048 |
| 125 | MP0002697_abnormal_eye_size | 0.17714024 |
| 126 | MP0004272_abnormal_basement_membrane | 0.17392325 |
| 127 | MP0001881_abnormal_mammary_gland | 0.17245856 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 7.20110849 |
| 2 | Deep venous thrombosis (HP:0002625) | 7.02097128 |
| 3 | Intrahepatic cholestasis (HP:0001406) | 7.00508709 |
| 4 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 6.30906162 |
| 5 | Prolonged partial thromboplastin time (HP:0003645) | 6.14265632 |
| 6 | Xanthomatosis (HP:0000991) | 6.00027613 |
| 7 | Hypobetalipoproteinemia (HP:0003563) | 5.92030983 |
| 8 | Hyperlipoproteinemia (HP:0010980) | 5.13419776 |
| 9 | Complement deficiency (HP:0004431) | 5.04976487 |
| 10 | Hyperammonemia (HP:0001987) | 4.66480417 |
| 11 | Joint hemorrhage (HP:0005261) | 4.55552081 |
| 12 | Hyperglycinemia (HP:0002154) | 4.55529518 |
| 13 | Hypolipoproteinemia (HP:0010981) | 4.50851546 |
| 14 | Ketosis (HP:0001946) | 4.47350062 |
| 15 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 4.39529504 |
| 16 | Abnormality of the common coagulation pathway (HP:0010990) | 4.33880377 |
| 17 | Hyperglycinuria (HP:0003108) | 4.30164778 |
| 18 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 4.23070984 |
| 19 | Abnormality of glycine metabolism (HP:0010895) | 4.19055583 |
| 20 | Abnormality of serine family amino acid metabolism (HP:0010894) | 4.19055583 |
| 21 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 4.17061455 |
| 22 | Fat malabsorption (HP:0002630) | 4.13548528 |
| 23 | Epidermoid cyst (HP:0200040) | 4.12282181 |
| 24 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 4.09984257 |
| 25 | Abnormality of methionine metabolism (HP:0010901) | 4.02934194 |
| 26 | Hypoalphalipoproteinemia (HP:0003233) | 3.98834269 |
| 27 | Hypoglycemic coma (HP:0001325) | 3.94674816 |
| 28 | Abnormality of the intrinsic pathway (HP:0010989) | 3.69241948 |
| 29 | Abnormality of complement system (HP:0005339) | 3.65084047 |
| 30 | Abnormality of pyrimidine metabolism (HP:0004353) | 3.61245993 |
| 31 | Conjugated hyperbilirubinemia (HP:0002908) | 3.59643647 |
| 32 | Osteomalacia (HP:0002749) | 3.57706902 |
| 33 | Nephritis (HP:0000123) | 3.49404270 |
| 34 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.49104930 |
| 35 | Hypercholesterolemia (HP:0003124) | 3.39483229 |
| 36 | Ketoacidosis (HP:0001993) | 3.38626501 |
| 37 | Gout (HP:0001997) | 3.35940146 |
| 38 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.28186340 |
| 39 | Hyperbilirubinemia (HP:0002904) | 3.26657308 |
| 40 | Abnormality of nucleobase metabolism (HP:0010932) | 3.25726579 |
| 41 | Delayed CNS myelination (HP:0002188) | 3.20097978 |
| 42 | Steatorrhea (HP:0002570) | 3.15712964 |
| 43 | Abnormality of serum amino acid levels (HP:0003112) | 3.10617923 |
| 44 | Abnormality of purine metabolism (HP:0004352) | 3.07966872 |
| 45 | Hepatocellular carcinoma (HP:0001402) | 2.97782872 |
| 46 | Metabolic acidosis (HP:0001942) | 2.90447809 |
| 47 | Spontaneous abortion (HP:0005268) | 2.88446080 |
| 48 | Myocardial infarction (HP:0001658) | 2.79562961 |
| 49 | Vascular calcification (HP:0004934) | 2.79461531 |
| 50 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.79152371 |
| 51 | Dicarboxylic aciduria (HP:0003215) | 2.79152371 |
| 52 | Lethargy (HP:0001254) | 2.75244314 |
| 53 | Hypochromic microcytic anemia (HP:0004840) | 2.71937592 |
| 54 | Systemic lupus erythematosus (HP:0002725) | 2.60559374 |
| 55 | Skin nodule (HP:0200036) | 2.57762421 |
| 56 | Cerebral edema (HP:0002181) | 2.53345087 |
| 57 | Generalized aminoaciduria (HP:0002909) | 2.48480098 |
| 58 | Cardiovascular calcification (HP:0011915) | 2.48158432 |
| 59 | Bifid scrotum (HP:0000048) | 2.47121663 |
| 60 | Hyperphosphaturia (HP:0003109) | 2.46765430 |
| 61 | Hypoglycemic seizures (HP:0002173) | 2.46665367 |
| 62 | Spastic diplegia (HP:0001264) | 2.43120780 |
| 63 | Purpura (HP:0000979) | 2.41955482 |
| 64 | Malnutrition (HP:0004395) | 2.39134334 |
| 65 | Acanthocytosis (HP:0001927) | 2.38117315 |
| 66 | Neonatal onset (HP:0003623) | 2.37014647 |
| 67 | Irritability (HP:0000737) | 2.36396491 |
| 68 | Late onset (HP:0003584) | 2.35020697 |
| 69 | Abnormal gallbladder morphology (HP:0012437) | 2.34873430 |
| 70 | Glomerulonephritis (HP:0000099) | 2.32199504 |
| 71 | Enlarged kidneys (HP:0000105) | 2.31158568 |
| 72 | Fair hair (HP:0002286) | 2.31026274 |
| 73 | Cholelithiasis (HP:0001081) | 2.30830544 |
| 74 | Proximal tubulopathy (HP:0000114) | 2.28661837 |
| 75 | Mitral stenosis (HP:0001718) | 2.26601753 |
| 76 | Esophageal varix (HP:0002040) | 2.25837728 |
| 77 | Vomiting (HP:0002013) | 2.25729912 |
| 78 | Pancreatitis (HP:0001733) | 2.25558493 |
| 79 | Reduced antithrombin III activity (HP:0001976) | 2.24605935 |
| 80 | Hyperuricemia (HP:0002149) | 2.24132416 |
| 81 | Increased purine levels (HP:0004368) | 2.24132416 |
| 82 | Alkalosis (HP:0001948) | 2.17835485 |
| 83 | Sensorimotor neuropathy (HP:0007141) | 2.17818105 |
| 84 | Abnormal gallbladder physiology (HP:0012438) | 2.17098317 |
| 85 | Cholecystitis (HP:0001082) | 2.17098317 |
| 86 | Amyloidosis (HP:0011034) | 2.16261753 |
| 87 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.12160581 |
| 88 | Abnormal urine phosphate concentration (HP:0012599) | 2.09775717 |
| 89 | Hydroxyprolinuria (HP:0003080) | 2.09333416 |
| 90 | Abnormality of proline metabolism (HP:0010907) | 2.09333416 |
| 91 | Rickets (HP:0002748) | 2.09311566 |
| 92 | Abnormality of the Achilles tendon (HP:0005109) | 2.08378828 |
| 93 | Abnormality of urine glucose concentration (HP:0011016) | 2.07400400 |
| 94 | Glycosuria (HP:0003076) | 2.07400400 |
| 95 | Thrombophlebitis (HP:0004418) | 2.06195929 |
| 96 | Gingival bleeding (HP:0000225) | 2.05027766 |
| 97 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.04838921 |
| 98 | Menorrhagia (HP:0000132) | 2.04216237 |
| 99 | Arthropathy (HP:0003040) | 2.02241717 |
| 100 | Pulmonary embolism (HP:0002204) | 2.01942051 |
| 101 | Elevated alkaline phosphatase (HP:0003155) | 2.01336575 |
| 102 | Opisthotonus (HP:0002179) | 2.00313893 |
| 103 | Brushfield spots (HP:0001088) | 1.99768179 |
| 104 | Abnormal enzyme/coenzyme activity (HP:0012379) | 1.97937513 |
| 105 | Abnormality of the gallbladder (HP:0005264) | 1.93208322 |
| 106 | Increased mean platelet volume (HP:0011877) | 1.92317739 |
| 107 | Hemorrhage of the eye (HP:0011885) | 1.91036115 |
| 108 | Abnormality of alkaline phosphatase activity (HP:0004379) | 1.91029944 |
| 109 | Hypophosphatemic rickets (HP:0004912) | 1.90968693 |
| 110 | Poikilocytosis (HP:0004447) | 1.90327440 |
| 111 | Abnormal cartilage morphology (HP:0002763) | 1.88589246 |
| 112 | Retinal atrophy (HP:0001105) | 1.88108264 |
| 113 | Joint swelling (HP:0001386) | 1.87319662 |
| 114 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.86902528 |
| 115 | Abnormality of vitamin metabolism (HP:0100508) | 1.83798675 |
| 116 | Abnormality of iron homeostasis (HP:0011031) | 1.83257083 |
| 117 | Increased serum ferritin (HP:0003281) | 1.71445622 |
| 118 | Abnormal platelet volume (HP:0011876) | 1.70344949 |
| 119 | Neonatal hypoglycemia (HP:0001998) | 1.67549913 |
| 120 | Bile duct proliferation (HP:0001408) | 1.64519490 |
| 121 | Abnormal biliary tract physiology (HP:0012439) | 1.64519490 |
| 122 | Impaired platelet aggregation (HP:0003540) | 1.63894595 |
| 123 | Abnormal platelet function (HP:0011869) | 1.63894595 |
| 124 | Hypophosphatemia (HP:0002148) | 1.60705057 |
| 125 | Hypochromic anemia (HP:0001931) | 1.58088877 |
| 126 | Generalized hypopigmentation of hair (HP:0011358) | 1.57291323 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BCKDK | 7.71887196 |
| 2 | FGFR4 | 4.40796119 |
| 3 | ERN1 | 4.33545125 |
| 4 | SIK1 | 4.06044083 |
| 5 | PASK | 2.95315754 |
| 6 | INSRR | 2.88408469 |
| 7 | TAOK3 | 2.79329720 |
| 8 | NTRK3 | 2.65166499 |
| 9 | ERBB4 | 2.61376619 |
| 10 | MAP3K9 | 2.30070594 |
| 11 | PKN2 | 2.29655836 |
| 12 | MST1R | 2.22734889 |
| 13 | TRIB3 | 2.17702169 |
| 14 | ARAF | 2.02369744 |
| 15 | MAP3K12 | 1.98960796 |
| 16 | MAP2K4 | 1.95481443 |
| 17 | MAPK11 | 1.84155020 |
| 18 | PRPF4B | 1.73039639 |
| 19 | PIK3CG | 1.71351217 |
| 20 | FRK | 1.68794253 |
| 21 | LATS1 | 1.68762946 |
| 22 | CDK12 | 1.68146487 |
| 23 | FLT3 | 1.67098223 |
| 24 | PTK6 | 1.60668219 |
| 25 | MAP3K13 | 1.54797112 |
| 26 | TYK2 | 1.47929895 |
| 27 | WNK4 | 1.44705996 |
| 28 | MAP3K2 | 1.44662387 |
| 29 | ABL2 | 1.39436870 |
| 30 | STK38L | 1.36386683 |
| 31 | DAPK2 | 1.36044902 |
| 32 | NEK9 | 1.27872102 |
| 33 | KSR2 | 1.21779134 |
| 34 | MAP3K7 | 1.20167222 |
| 35 | KDR | 1.19823402 |
| 36 | PINK1 | 1.19327208 |
| 37 | FGFR2 | 1.13678285 |
| 38 | PRKAA2 | 1.10966074 |
| 39 | LMTK2 | 1.09200110 |
| 40 | JAK2 | 1.09188106 |
| 41 | GRK6 | 1.04744240 |
| 42 | EPHB1 | 1.03282131 |
| 43 | ERBB2 | 0.98791968 |
| 44 | MAP2K3 | 0.96946346 |
| 45 | NLK | 0.95876268 |
| 46 | MAP3K3 | 0.93534534 |
| 47 | TBK1 | 0.90871829 |
| 48 | MET | 0.90302261 |
| 49 | MAPK15 | 0.88959982 |
| 50 | WNK3 | 0.88086022 |
| 51 | MAP3K10 | 0.87459288 |
| 52 | CDK9 | 0.86743380 |
| 53 | PRKCZ | 0.85840847 |
| 54 | TIE1 | 0.85567397 |
| 55 | MAPKAPK3 | 0.84677412 |
| 56 | JAK1 | 0.82408606 |
| 57 | CSNK1D | 0.82179267 |
| 58 | DYRK1B | 0.81222110 |
| 59 | EPHA4 | 0.80171035 |
| 60 | MAPK4 | 0.78932189 |
| 61 | IRAK3 | 0.78283490 |
| 62 | MAPK12 | 0.77247025 |
| 63 | PRKG1 | 0.76868604 |
| 64 | MAP3K11 | 0.75449288 |
| 65 | FER | 0.74400508 |
| 66 | RIPK1 | 0.73539036 |
| 67 | MAP3K14 | 0.72889425 |
| 68 | GSK3A | 0.72679828 |
| 69 | PRKACG | 0.71309412 |
| 70 | EPHA2 | 0.70188794 |
| 71 | PRKAA1 | 0.69961611 |
| 72 | PRKACA | 0.69260331 |
| 73 | OXSR1 | 0.68085452 |
| 74 | MAP2K6 | 0.67757987 |
| 75 | PTK2 | 0.67545788 |
| 76 | NEK6 | 0.67268201 |
| 77 | ZAP70 | 0.65848172 |
| 78 | EPHA3 | 0.65596970 |
| 79 | TGFBR2 | 0.65025247 |
| 80 | CAMK2G | 0.63651211 |
| 81 | SGK3 | 0.62610629 |
| 82 | PDK3 | 0.61879975 |
| 83 | PDK4 | 0.61879975 |
| 84 | CDK6 | 0.61802766 |
| 85 | CSK | 0.59756923 |
| 86 | CSNK1E | 0.58009241 |
| 87 | TNK2 | 0.57492297 |
| 88 | LRRK2 | 0.56908110 |
| 89 | MELK | 0.56313206 |
| 90 | MAP2K2 | 0.55913072 |
| 91 | PDPK1 | 0.55832752 |
| 92 | CAMK1D | 0.51914513 |
| 93 | MUSK | 0.50961402 |
| 94 | NTRK1 | 0.50880637 |
| 95 | SGK494 | 0.50579500 |
| 96 | SGK223 | 0.50579500 |
| 97 | MAP2K1 | 0.48630914 |
| 98 | RAF1 | 0.48179989 |
| 99 | LATS2 | 0.45005632 |
| 100 | SGK2 | 0.43306828 |
| 101 | FGFR3 | 0.43172316 |
| 102 | TAOK2 | 0.42688694 |
| 103 | PRKCB | 0.42611599 |
| 104 | FGFR1 | 0.42154804 |
| 105 | MAPK7 | 0.42107347 |
| 106 | PRKACB | 0.42064020 |
| 107 | MTOR | 0.41308589 |
| 108 | PRKCQ | 0.41113107 |
| 109 | RPS6KA3 | 0.40695678 |
| 110 | GRK1 | 0.40457049 |
| 111 | CHUK | 0.40307202 |
| 112 | MAP3K5 | 0.39634504 |
| 113 | PDGFRA | 0.39409500 |
| 114 | ICK | 0.38364350 |
| 115 | PIK3CA | 0.37208641 |
| 116 | SRC | 0.36795246 |
| 117 | IGF1R | 0.36722653 |
| 118 | CSNK1G1 | 0.36486385 |
| 119 | ACVR1B | 0.36298164 |
| 120 | CDK4 | 0.35894223 |
| 121 | IKBKE | 0.35368248 |
| 122 | STK24 | 0.34215066 |
| 123 | BCR | 0.34171161 |
| 124 | PKN1 | 0.33738015 |
| 125 | NEK1 | 0.33123918 |
| 126 | RET | 0.31706699 |
| 127 | PDK1 | 0.31426998 |
| 128 | PAK3 | 0.31381803 |
| 129 | CSF1R | 0.30881698 |
| 130 | CAMK4 | 0.29363375 |
| 131 | MYLK | 0.28646756 |
| 132 | PDK2 | 0.28372052 |
| 133 | PRKCG | 0.27321318 |
| 134 | EGFR | 0.26786998 |
| 135 | IRAK1 | 0.24478805 |
| 136 | STK38 | 0.24357516 |
| 137 | IRAK2 | 0.24303847 |
| 138 | PRKCA | 0.24199922 |
| 139 | MAP3K1 | 0.24132504 |
| 140 | OBSCN | 0.22218582 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 4.28108486 |
| 2 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.45183966 |
| 3 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.37703710 |
| 4 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 3.37292217 |
| 5 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.95427634 |
| 6 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.73772760 |
| 7 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.67203430 |
| 8 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 2.62059331 |
| 9 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.59233240 |
| 10 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.57156581 |
| 11 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.53698942 |
| 12 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.53616196 |
| 13 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.28531678 |
| 14 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.27737536 |
| 15 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.11789339 |
| 16 | Peroxisome_Homo sapiens_hsa04146 | 2.10435681 |
| 17 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.07104946 |
| 18 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.86226530 |
| 19 | Histidine metabolism_Homo sapiens_hsa00340 | 1.85159229 |
| 20 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.83506307 |
| 21 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.82573897 |
| 22 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.80886479 |
| 23 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.78751878 |
| 24 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.76931223 |
| 25 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.74521448 |
| 26 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.69026279 |
| 27 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.68686485 |
| 28 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.65068455 |
| 29 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.62154778 |
| 30 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.60298101 |
| 31 | Retinol metabolism_Homo sapiens_hsa00830 | 1.58012534 |
| 32 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.56472533 |
| 33 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.53591577 |
| 34 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.52098035 |
| 35 | Bile secretion_Homo sapiens_hsa04976 | 1.50404523 |
| 36 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.48769887 |
| 37 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.42273746 |
| 38 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.41325673 |
| 39 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.36394315 |
| 40 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.34812081 |
| 41 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.32891274 |
| 42 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.29092099 |
| 43 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.28265494 |
| 44 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.28258170 |
| 45 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.27189333 |
| 46 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.22898078 |
| 47 | Carbon metabolism_Homo sapiens_hsa01200 | 1.22410690 |
| 48 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.21220246 |
| 49 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.14829758 |
| 50 | ABC transporters_Homo sapiens_hsa02010 | 1.11938242 |
| 51 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.08088706 |
| 52 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.06233599 |
| 53 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.05540298 |
| 54 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.02224480 |
| 55 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.95322211 |
| 56 | Sulfur relay system_Homo sapiens_hsa04122 | 0.91895592 |
| 57 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.86534657 |
| 58 | Lysine degradation_Homo sapiens_hsa00310 | 0.86071117 |
| 59 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.82969264 |
| 60 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.79446048 |
| 61 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.76187507 |
| 62 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.76003915 |
| 63 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.73773369 |
| 64 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.73165368 |
| 65 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.58248829 |
| 66 | Metabolic pathways_Homo sapiens_hsa01100 | 0.48414485 |
| 67 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.41984811 |
| 68 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.39507109 |
| 69 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.30517816 |
| 70 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.30426741 |
| 71 | Prion diseases_Homo sapiens_hsa05020 | 0.28538734 |
| 72 | Galactose metabolism_Homo sapiens_hsa00052 | 0.27731703 |
| 73 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.23160321 |
| 74 | Insulin resistance_Homo sapiens_hsa04931 | 0.22798472 |
| 75 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.20485693 |
| 76 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.18382195 |
| 77 | Pertussis_Homo sapiens_hsa05133 | 0.18249973 |
| 78 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.12351976 |
| 79 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.08624231 |
| 80 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.04160641 |
| 81 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.02465470 |
| 82 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | -0.2284253 |
| 83 | Bladder cancer_Homo sapiens_hsa05219 | -0.2201813 |
| 84 | African trypanosomiasis_Homo sapiens_hsa05143 | -0.2077839 |
| 85 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | -0.2014514 |
| 86 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | -0.1906537 |
| 87 | Mineral absorption_Homo sapiens_hsa04978 | -0.1879278 |
| 88 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | -0.1853733 |
| 89 | Hepatitis C_Homo sapiens_hsa05160 | -0.1762513 |
| 90 | Ether lipid metabolism_Homo sapiens_hsa00565 | -0.1717212 |
| 91 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | -0.1706837 |
| 92 | Pancreatic secretion_Homo sapiens_hsa04972 | -0.1572161 |
| 93 | Regulation of autophagy_Homo sapiens_hsa04140 | -0.1526850 |
| 94 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | -0.1426410 |
| 95 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | -0.1368987 |
| 96 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | -0.1345104 |
| 97 | Circadian rhythm_Homo sapiens_hsa04710 | -0.1271405 |
| 98 | Type II diabetes mellitus_Homo sapiens_hsa04930 | -0.1234254 |
| 99 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | -0.1160855 |
| 100 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | -0.1106996 |
| 101 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | -0.1086047 |
| 102 | Insulin signaling pathway_Homo sapiens_hsa04910 | -0.1077507 |
| 103 | Amoebiasis_Homo sapiens_hsa05146 | -0.1000602 |
| 104 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | -0.0990932 |
| 105 | Renin-angiotensin system_Homo sapiens_hsa04614 | -0.0595251 |
| 106 | Sphingolipid metabolism_Homo sapiens_hsa00600 | -0.0550931 |
| 107 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | -0.0543839 |
| 108 | Serotonergic synapse_Homo sapiens_hsa04726 | -0.0198821 |
| 109 | Other glycan degradation_Homo sapiens_hsa00511 | -0.0051274 |
| 110 | Protein digestion and absorption_Homo sapiens_hsa04974 | -0.0051087 |

