HABP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by hepatocytes and proteolytically processed to generate heavy and light chains that form the mature heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This extracellular protease binds hyaluronic acid and may play a role in the coagulation and fibrinolysis systems. Mutations in this gene are associated with nonmedullary thyroid cancer and susceptibility to venous thromboembolism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.56384074
2L-phenylalanine catabolic process (GO:0006559)7.56384074
3epoxygenase P450 pathway (GO:0019373)7.42899180
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.27380900
5L-phenylalanine metabolic process (GO:0006558)7.27380900
6omega-hydroxylase P450 pathway (GO:0097267)7.05158683
7aromatic amino acid family catabolic process (GO:0009074)6.75990593
8tryptophan catabolic process (GO:0006569)6.07926640
9indole-containing compound catabolic process (GO:0042436)6.07926640
10indolalkylamine catabolic process (GO:0046218)6.07926640
11oxidative demethylation (GO:0070989)6.06838169
12glyoxylate metabolic process (GO:0046487)6.06638472
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.02930053
14kynurenine metabolic process (GO:0070189)5.90426717
15drug metabolic process (GO:0017144)5.84435836
16bile acid biosynthetic process (GO:0006699)5.75718978
17tryptophan metabolic process (GO:0006568)5.73452307
18cysteine metabolic process (GO:0006534)5.65193419
19negative regulation of fibrinolysis (GO:0051918)5.43246951
20urea cycle (GO:0000050)5.41334186
21urea metabolic process (GO:0019627)5.41334186
22phenylpropanoid metabolic process (GO:0009698)5.37552715
23alpha-linolenic acid metabolic process (GO:0036109)5.34266035
24sulfur amino acid catabolic process (GO:0000098)5.33233585
25high-density lipoprotein particle remodeling (GO:0034375)5.31295959
26regulation of plasminogen activation (GO:0010755)5.29831833
27serine family amino acid catabolic process (GO:0009071)5.23223892
28regulation of fibrinolysis (GO:0051917)5.21539303
29peptidyl-glutamic acid carboxylation (GO:0017187)5.20079161
30protein carboxylation (GO:0018214)5.20079161
31negative regulation of blood coagulation (GO:0030195)5.15528867
32negative regulation of hemostasis (GO:1900047)5.15528867
33regulation of protein activation cascade (GO:2000257)5.12809463
34complement activation, alternative pathway (GO:0006957)5.09091040
35lysine catabolic process (GO:0006554)5.04172388
36lysine metabolic process (GO:0006553)5.04172388
37nitrogen cycle metabolic process (GO:0071941)4.99140198
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.98033940
39homocysteine metabolic process (GO:0050667)4.94413555
40aromatic amino acid family metabolic process (GO:0009072)4.92147599
41bile acid metabolic process (GO:0008206)4.91650540
42regulation of complement activation (GO:0030449)4.77570997
43S-adenosylmethionine metabolic process (GO:0046500)4.71960990
44negative regulation of coagulation (GO:0050819)4.71680860
45alpha-amino acid catabolic process (GO:1901606)4.68970327
46reverse cholesterol transport (GO:0043691)4.68603204
47amino-acid betaine metabolic process (GO:0006577)4.67507743
48negative regulation of lipase activity (GO:0060192)4.66027745
49polyketide metabolic process (GO:0030638)4.65568771
50doxorubicin metabolic process (GO:0044598)4.65568771
51daunorubicin metabolic process (GO:0044597)4.65568771
52regulation of cholesterol esterification (GO:0010872)4.64757853
53regulation of triglyceride catabolic process (GO:0010896)4.63974410
54tyrosine metabolic process (GO:0006570)4.63162730
55negative regulation of wound healing (GO:0061045)4.61040609
56protein-lipid complex remodeling (GO:0034368)4.56153827
57macromolecular complex remodeling (GO:0034367)4.56153827
58plasma lipoprotein particle remodeling (GO:0034369)4.56153827
59cellular ketone body metabolic process (GO:0046950)4.54485460
60acylglycerol homeostasis (GO:0055090)4.44858847
61triglyceride homeostasis (GO:0070328)4.44858847
62glycine metabolic process (GO:0006544)4.43963793
63negative regulation of cholesterol transport (GO:0032375)4.41943311
64negative regulation of sterol transport (GO:0032372)4.41943311
65fat-soluble vitamin biosynthetic process (GO:0042362)4.40715017
66serine family amino acid metabolic process (GO:0009069)4.37654214
67ethanol metabolic process (GO:0006067)4.37080932
68cellular amino acid catabolic process (GO:0009063)4.36292068
69alkaloid metabolic process (GO:0009820)4.34907531
70phospholipid efflux (GO:0033700)4.34512954
71coenzyme catabolic process (GO:0009109)4.33909785
72indolalkylamine metabolic process (GO:0006586)4.30614504
73cellular modified amino acid catabolic process (GO:0042219)4.30558465
74positive regulation of hemostasis (GO:1900048)4.28978761
75positive regulation of blood coagulation (GO:0030194)4.28978761
76protein activation cascade (GO:0072376)4.28402233
77glutamate metabolic process (GO:0006536)4.28278328
78plasma lipoprotein particle clearance (GO:0034381)4.21880933
79bile acid and bile salt transport (GO:0015721)4.21220192
80serine family amino acid biosynthetic process (GO:0009070)4.19775398
81drug catabolic process (GO:0042737)4.19176516
82amine catabolic process (GO:0009310)4.18988953
83cellular biogenic amine catabolic process (GO:0042402)4.18988953
84regulation of humoral immune response (GO:0002920)4.16709211
85cellular glucuronidation (GO:0052695)4.15493647
86heme transport (GO:0015886)4.14791479
87aminoglycoside antibiotic metabolic process (GO:0030647)4.12396983
88hormone catabolic process (GO:0042447)4.11615114
89benzene-containing compound metabolic process (GO:0042537)4.11419259
90imidazole-containing compound metabolic process (GO:0052803)4.07025215
91acute-phase response (GO:0006953)4.06918068
92ethanol oxidation (GO:0006069)4.05469153
93positive regulation of coagulation (GO:0050820)4.00766912
94cholesterol efflux (GO:0033344)4.00058680
95dicarboxylic acid biosynthetic process (GO:0043650)3.99740621
96flavonoid metabolic process (GO:0009812)3.96947468
97short-chain fatty acid metabolic process (GO:0046459)3.96420432
98response to mercury ion (GO:0046689)3.96099539
99aldehyde catabolic process (GO:0046185)3.95183844
100ketone body metabolic process (GO:1902224)3.92998132
101negative regulation of protein activation cascade (GO:2000258)3.91094284
102urate metabolic process (GO:0046415)3.89852754
103drug transmembrane transport (GO:0006855)3.88279611
104arginine metabolic process (GO:0006525)3.88144623
105fibrinolysis (GO:0042730)3.87137316
106negative regulation of fatty acid biosynthetic process (GO:0045717)3.84862299
107plasma lipoprotein particle assembly (GO:0034377)3.84795467
108primary alcohol catabolic process (GO:0034310)3.84560555
109aspartate family amino acid catabolic process (GO:0009068)3.83277564
110organic acid catabolic process (GO:0016054)3.83143250
111carboxylic acid catabolic process (GO:0046395)3.83143250
112regulation of lipoprotein particle clearance (GO:0010984)3.80951454
113positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.75064253
114low-density lipoprotein particle remodeling (GO:0034374)3.74928847
115acetyl-CoA metabolic process (GO:0006084)3.74725921
116regulation of bile acid biosynthetic process (GO:0070857)3.73466385
117uronic acid metabolic process (GO:0006063)3.72930426
118glucuronate metabolic process (GO:0019585)3.72930426
119phospholipid homeostasis (GO:0055091)3.71050349
120cofactor catabolic process (GO:0051187)3.69337308
121cholesterol homeostasis (GO:0042632)3.68893946
122positive regulation of lipoprotein lipase activity (GO:0051006)3.67784814
123positive regulation of triglyceride lipase activity (GO:0061365)3.67784814
124regulation of cholesterol homeostasis (GO:2000188)3.67604496
125intestinal cholesterol absorption (GO:0030299)3.66357838
126blood coagulation, intrinsic pathway (GO:0007597)3.65284881
127exogenous drug catabolic process (GO:0042738)3.64691073
128sterol homeostasis (GO:0055092)3.64093772
129L-methionine salvage (GO:0071267)3.63163282
130L-methionine biosynthetic process (GO:0071265)3.63163282
131amino acid salvage (GO:0043102)3.63163282
132xenobiotic metabolic process (GO:0006805)3.62076909
1332-oxoglutarate metabolic process (GO:0006103)3.60501375
134positive regulation of lipid catabolic process (GO:0050996)3.59041878
135complement activation, classical pathway (GO:0006958)3.57516339
136monocarboxylic acid catabolic process (GO:0072329)3.54059779
137very-low-density lipoprotein particle assembly (GO:0034379)3.54038154
138complement activation (GO:0006956)3.53293158

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.27582856
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.14341167
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.74640105
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.43404932
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.18617642
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.96092881
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.95871362
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.98776962
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.88959282
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.16177255
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12451547
12* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.04696635
13* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7903355
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77688325
15* FOXA2_19822575_ChIP-Seq_HepG2_Human1.65221083
16CLOCK_20551151_ChIP-Seq_293T_Human1.65006116
17* HNF4A_19822575_ChIP-Seq_HepG2_Human1.45652028
18HTT_18923047_ChIP-ChIP_STHdh_Human1.43628618
19GATA1_22025678_ChIP-Seq_K562_Human1.39519133
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28650742
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25712638
22RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17680167
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.16562915
24* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10462379
25ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09011484
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08222147
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04231965
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00120428
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98386877
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97886773
31ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97103622
32* GATA4_25053715_ChIP-Seq_YYC3_Human0.96006116
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94367501
34ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90800181
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90207025
36CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.88123395
37IRF1_19129219_ChIP-ChIP_H3396_Human0.86967830
38ESR2_21235772_ChIP-Seq_MCF-7_Human0.85994439
39* HNFA_21074721_ChIP-Seq_CACO-2_Human0.85939861
40IRF8_22096565_ChIP-ChIP_GC-B_Human0.84476016
41PHF8_20622853_ChIP-Seq_HELA_Human0.80689774
42AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80579815
43SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78840292
44ZNF263_19887448_ChIP-Seq_K562_Human0.78727725
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77803621
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.76867199
47TP53_18474530_ChIP-ChIP_U2OS_Human0.76107214
48ESR1_21235772_ChIP-Seq_MCF-7_Human0.76026841
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75421144
50SOX2_21211035_ChIP-Seq_LN229_Human0.74456594
51SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73959947
52KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73537382
53RARA_24833708_ChIP-Seq_LIVER_Mouse0.73393476
54AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73166246
55CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73155361
56CDX2_19796622_ChIP-Seq_MESCs_Mouse0.73110523
57NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.72708680
58* NFYA_21822215_ChIP-Seq_K562_Human0.70469069
59NFE2_27457419_Chip-Seq_LIVER_Mouse0.69967038
60PIAS1_25552417_ChIP-Seq_VCAP_Human0.68877601
61* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.66914844
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.66172025
63BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66027174
64EZH2_22144423_ChIP-Seq_EOC_Human0.65854546
65Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.65632726
66GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.65624914
67RAD21_21589869_ChIP-Seq_MESCs_Mouse0.65550673
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65238632
69LXR_22292898_ChIP-Seq_THP-1_Human0.64592745
70CDX2_20551321_ChIP-Seq_CACO-2_Human0.64358583
71EGR1_19032775_ChIP-ChIP_M12_Human0.63951513
72* FOXH1_21741376_ChIP-Seq_EPCs_Human0.63905789
73STAT3_1855785_ChIP-Seq_MESCs_Mouse0.63539982
74BCAT_22108803_ChIP-Seq_LS180_Human0.63247679
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.61534649
76CEBPB_22108803_ChIP-Seq_LS180_Human0.61015635
77PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.60725193
78RARB_24833708_ChIP-Seq_LIVER_Mouse0.60691938
79GATA6_21074721_ChIP-Seq_CACO-2_Human0.60478413
80EZH2_27294783_Chip-Seq_NPCs_Mouse0.60278632
81TCF4_18268006_ChIP-ChIP_LS174T_Human0.58862357
82EP300_21415370_ChIP-Seq_HL-1_Mouse0.58699367
83KLF5_20875108_ChIP-Seq_MESCs_Mouse0.57363095
84* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.57189415
85* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.57189415
86CBX2_22325352_ChIP-Seq_293T-Rex_Human0.56891120
87CBP_20019798_ChIP-Seq_JUKART_Human0.56732674
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.56732674
89* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.55281488
90* GATA6_25053715_ChIP-Seq_YYC3_Human0.55058522
91AR_20517297_ChIP-Seq_VCAP_Human0.54541382
92RAC3_21632823_ChIP-Seq_H3396_Human0.54350140
93PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.54296770
94* FOXA1_25552417_ChIP-Seq_VCAP_Human0.54278784
95FOXO3_23340844_ChIP-Seq_DLD1_Human0.53345940
96ESET_19884257_ChIP-Seq_ESCs_Mouse0.53207906
97FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52413489
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.52115435
99* MYC_19915707_ChIP-ChIP_AK7_Human0.51517896
100* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51392582
101ETV1_20927104_ChIP-Seq_GIST48_Human0.50634490
102SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.48839001
103GF1_26923725_Chip-Seq_HPCs_Mouse0.48403711
104* NFYB_21822215_ChIP-Seq_K562_Human0.48350356
105* CBP_21632823_ChIP-Seq_H3396_Human0.48027107
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.47976053
107P53_21459846_ChIP-Seq_SAOS-2_Human0.47954551
108SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.47700444
109GATA1_19941826_ChIP-Seq_K562_Human0.47561172
110FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.47402981
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.47360099
112ESR1_20079471_ChIP-ChIP_T-47D_Human0.47266848
113STAT1_17558387_ChIP-Seq_HELA_Human0.47191306
114ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.46771761
115PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45683288
116GATA1_19941827_ChIP-Seq_MEL_Mouse0.45649352
117ETV2_25802403_ChIP-Seq_MESCs_Mouse0.45633304
118EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.45343445
119* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.45201354
120ERG_21242973_ChIP-ChIP_JURKAT_Human0.45019348
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.44928570
122* TAF2_19829295_ChIP-Seq_ESCs_Human0.44609196
123GATA2_19941826_ChIP-Seq_K562_Human0.44475425
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.44174186
125PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.43657324
126STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.41373610
127SOX2_20726797_ChIP-Seq_SW620_Human0.41070218
128CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.40325644
129GATA3_24758297_ChIP-Seq_MCF-7_Human0.38476245
130ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.38407592
131GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.37901796
132P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.37761847
133TBX20_22080862_ChIP-Seq_HEART_Mouse0.37569045
134TBX20_22328084_ChIP-Seq_HEART_Mouse0.37569045
135MYC_27129775_Chip-Seq_CORNEA_Mouse0.37251105
136SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.37210880
137RACK7_27058665_Chip-Seq_MCF-7_Human0.36677548
138CDX2_22108803_ChIP-Seq_LS180_Human0.36518461
139ERG_20517297_ChIP-Seq_VCAP_Human0.36372201

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.15273129
2MP0005360_urolithiasis7.61100820
3MP0005085_abnormal_gallbladder_physiolo6.29514706
4MP0005365_abnormal_bile_salt6.14442044
5MP0008875_abnormal_xenobiotic_pharmacok4.87862149
6MP0003806_abnormal_nucleotide_metabolis4.09623405
7MP0003252_abnormal_bile_duct3.89910048
8MP0010329_abnormal_lipoprotein_level3.41866796
9MP0005083_abnormal_biliary_tract3.40820820
10MP0009840_abnormal_foam_cell3.05681910
11MP0005332_abnormal_amino_acid2.97554315
12MP0003195_calcinosis2.95152224
13MP0001666_abnormal_nutrient_absorption2.94962008
14MP0004019_abnormal_vitamin_homeostasis2.36721762
15MP0002138_abnormal_hepatobiliary_system2.31303345
16MP0003191_abnormal_cellular_cholesterol2.28849924
17MP0000609_abnormal_liver_physiology2.07340919
18MP0002118_abnormal_lipid_homeostasis2.06403416
19MP0003868_abnormal_feces_composition1.95593172
20MP0005319_abnormal_enzyme/_coenzyme1.83431231
21MP0001764_abnormal_homeostasis1.62731853
22MP0005584_abnormal_enzyme/coenzyme_acti1.56102425
23MP0009643_abnormal_urine_homeostasis1.49761765
24MP0005451_abnormal_body_composition1.40632511
25MP0009697_abnormal_copulation1.37815080
26MP0003186_abnormal_redox_activity1.31953827
27MP0003011_delayed_dark_adaptation1.23531177
28MP0003656_abnormal_erythrocyte_physiolo1.19730475
29MP0003705_abnormal_hypodermis_morpholog1.18557762
30MP0005084_abnormal_gallbladder_morpholo1.17507789
31MP0000598_abnormal_liver_morphology1.16329878
32MP0005636_abnormal_mineral_homeostasis1.13876861
33MP0005647_abnormal_sex_gland1.03524880
34MP0005220_abnormal_exocrine_pancreas1.02853401
35MP0003879_abnormal_hair_cell1.00351866
36MP0009764_decreased_sensitivity_to1.00065515
37MP0000604_amyloidosis0.98833838
38MP0009763_increased_sensitivity_to0.95499455
39MP0006036_abnormal_mitochondrial_physio0.94525267
40MP0010368_abnormal_lymphatic_system0.92500373
41MP0002254_reproductive_system_inflammat0.90220852
42MP0009642_abnormal_blood_homeostasis0.88239854
43MP0000566_synostosis0.88125805
44MP0008469_abnormal_protein_level0.87238447
45MP0005408_hypopigmentation0.85530262
46MP0005670_abnormal_white_adipose0.79767284
47MP0002078_abnormal_glucose_homeostasis0.79166482
48MP0001756_abnormal_urination0.77924989
49MP0002876_abnormal_thyroid_physiology0.76727666
50MP0001915_intracranial_hemorrhage0.76267037
51MP0005376_homeostasis/metabolism_phenot0.74695725
52MP0009765_abnormal_xenobiotic_induced0.74653532
53MP0005535_abnormal_body_temperature0.69225611
54MP0002971_abnormal_brown_adipose0.68231422
55MP0001661_extended_life_span0.68154972
56MP0004130_abnormal_muscle_cell0.67523007
57MP0005187_abnormal_penis_morphology0.66746657
58MP0004043_abnormal_pH_regulation0.66114372
59MP0005334_abnormal_fat_pad0.65575322
60MP0005023_abnormal_wound_healing0.65172849
61MP0002136_abnormal_kidney_physiology0.64887137
62MP0002928_abnormal_bile_duct0.62959671
63MP0002132_abnormal_respiratory_system0.62493994
64MP0003283_abnormal_digestive_organ0.61468578
65MP0005266_abnormal_metabolism0.61001150
66MP0006035_abnormal_mitochondrial_morpho0.59603747
67MP0009053_abnormal_anal_canal0.58193497
68MP0003329_amyloid_beta_deposits0.57935915
69MP0005448_abnormal_energy_balance0.55632369
70MP0002837_dystrophic_cardiac_calcinosis0.55348616
71MP0003690_abnormal_glial_cell0.55248233
72MP0003638_abnormal_response/metabolism_0.52987762
73MP0000639_abnormal_adrenal_gland0.49580532
74MP0005395_other_phenotype0.49431081
75MP0005666_abnormal_adipose_tissue0.44848194
76MP0005464_abnormal_platelet_physiology0.43978825
77MP0003953_abnormal_hormone_level0.43829731
78MP0005164_abnormal_response_to0.43494332
79MP0001765_abnormal_ion_homeostasis0.43180285
80MP0009384_cardiac_valve_regurgitation0.40446842
81MP0004264_abnormal_extraembryonic_tissu0.40406175
82MP0002249_abnormal_larynx_morphology0.40166231
83MP0008873_increased_physiological_sensi0.39438555
84MP0002796_impaired_skin_barrier0.39205719
85MP0008874_decreased_physiological_sensi0.38776736
86MP0002089_abnormal_postnatal_growth/wei0.38743517
87MP0009672_abnormal_birth_weight0.38308592
88MP0002822_catalepsy0.38259984
89MP0005058_abnormal_lysosome_morphology0.38026228
90MP0003718_maternal_effect0.37815352
91MP0002168_other_aberrant_phenotype0.37742921
92MP0000230_abnormal_systemic_arterial0.37659175
93MP0002282_abnormal_trachea_morphology0.37553338
94MP0005166_decreased_susceptibility_to0.35344796
95MP0003075_altered_response_to0.34971857
96MP0003724_increased_susceptibility_to0.34932199
97MP0003699_abnormal_female_reproductive0.34752607
98MP0008872_abnormal_physiological_respon0.34052183
99MP0004883_abnormal_blood_vessel0.33664467
100MP0004782_abnormal_surfactant_physiolog0.33375588
101MP0000579_abnormal_nail_morphology0.31406423
102MP0010386_abnormal_urinary_bladder0.31159130
103MP0003632_abnormal_nervous_system0.30742150
104MP0003959_abnormal_lean_body0.30454835
105MP0002135_abnormal_kidney_morphology0.30201867
106MP0009115_abnormal_fat_cell0.29766610
107MP0003436_decreased_susceptibility_to0.29327419
108MP0002970_abnormal_white_adipose0.28753142
109MP0005197_abnormal_uvea_morphology0.28573841
110MP0003943_abnormal_hepatobiliary_system0.27943028
111MP0001845_abnormal_inflammatory_respons0.27649228
112MP0005248_abnormal_Harderian_gland0.27371116
113MP0010234_abnormal_vibrissa_follicle0.27077690
114MP0000249_abnormal_blood_vessel0.27062952
115MP0001944_abnormal_pancreas_morphology0.26427246
116MP0001243_abnormal_dermal_layer0.24449887
117MP0002269_muscular_atrophy0.24047465
118MP0000467_abnormal_esophagus_morphology0.22927049
119MP0000920_abnormal_myelination0.22713469
120MP0003878_abnormal_ear_physiology0.21711968
121MP0005377_hearing/vestibular/ear_phenot0.21711968
122MP0004142_abnormal_muscle_tone0.20230598
123MP0003890_abnormal_embryonic-extraembry0.19050126
124MP0001851_eye_inflammation0.18184048
125MP0002697_abnormal_eye_size0.17714024
126MP0004272_abnormal_basement_membrane0.17392325
127MP0001881_abnormal_mammary_gland0.17245856

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.20110849
2Deep venous thrombosis (HP:0002625)7.02097128
3Intrahepatic cholestasis (HP:0001406)7.00508709
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.30906162
5Prolonged partial thromboplastin time (HP:0003645)6.14265632
6Xanthomatosis (HP:0000991)6.00027613
7Hypobetalipoproteinemia (HP:0003563)5.92030983
8Hyperlipoproteinemia (HP:0010980)5.13419776
9Complement deficiency (HP:0004431)5.04976487
10Hyperammonemia (HP:0001987)4.66480417
11Joint hemorrhage (HP:0005261)4.55552081
12Hyperglycinemia (HP:0002154)4.55529518
13Hypolipoproteinemia (HP:0010981)4.50851546
14Ketosis (HP:0001946)4.47350062
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.39529504
16Abnormality of the common coagulation pathway (HP:0010990)4.33880377
17Hyperglycinuria (HP:0003108)4.30164778
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.23070984
19Abnormality of glycine metabolism (HP:0010895)4.19055583
20Abnormality of serine family amino acid metabolism (HP:0010894)4.19055583
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.17061455
22Fat malabsorption (HP:0002630)4.13548528
23Epidermoid cyst (HP:0200040)4.12282181
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.09984257
25Abnormality of methionine metabolism (HP:0010901)4.02934194
26Hypoalphalipoproteinemia (HP:0003233)3.98834269
27Hypoglycemic coma (HP:0001325)3.94674816
28Abnormality of the intrinsic pathway (HP:0010989)3.69241948
29Abnormality of complement system (HP:0005339)3.65084047
30Abnormality of pyrimidine metabolism (HP:0004353)3.61245993
31Conjugated hyperbilirubinemia (HP:0002908)3.59643647
32Osteomalacia (HP:0002749)3.57706902
33Nephritis (HP:0000123)3.49404270
34Abnormality of fatty-acid metabolism (HP:0004359)3.49104930
35Hypercholesterolemia (HP:0003124)3.39483229
36Ketoacidosis (HP:0001993)3.38626501
37Gout (HP:0001997)3.35940146
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.28186340
39Hyperbilirubinemia (HP:0002904)3.26657308
40Abnormality of nucleobase metabolism (HP:0010932)3.25726579
41Delayed CNS myelination (HP:0002188)3.20097978
42Steatorrhea (HP:0002570)3.15712964
43Abnormality of serum amino acid levels (HP:0003112)3.10617923
44Abnormality of purine metabolism (HP:0004352)3.07966872
45Hepatocellular carcinoma (HP:0001402)2.97782872
46Metabolic acidosis (HP:0001942)2.90447809
47Spontaneous abortion (HP:0005268)2.88446080
48Myocardial infarction (HP:0001658)2.79562961
49Vascular calcification (HP:0004934)2.79461531
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.79152371
51Dicarboxylic aciduria (HP:0003215)2.79152371
52Lethargy (HP:0001254)2.75244314
53Hypochromic microcytic anemia (HP:0004840)2.71937592
54Systemic lupus erythematosus (HP:0002725)2.60559374
55Skin nodule (HP:0200036)2.57762421
56Cerebral edema (HP:0002181)2.53345087
57Generalized aminoaciduria (HP:0002909)2.48480098
58Cardiovascular calcification (HP:0011915)2.48158432
59Bifid scrotum (HP:0000048)2.47121663
60Hyperphosphaturia (HP:0003109)2.46765430
61Hypoglycemic seizures (HP:0002173)2.46665367
62Spastic diplegia (HP:0001264)2.43120780
63Purpura (HP:0000979)2.41955482
64Malnutrition (HP:0004395)2.39134334
65Acanthocytosis (HP:0001927)2.38117315
66Neonatal onset (HP:0003623)2.37014647
67Irritability (HP:0000737)2.36396491
68Late onset (HP:0003584)2.35020697
69Abnormal gallbladder morphology (HP:0012437)2.34873430
70Glomerulonephritis (HP:0000099)2.32199504
71Enlarged kidneys (HP:0000105)2.31158568
72Fair hair (HP:0002286)2.31026274
73Cholelithiasis (HP:0001081)2.30830544
74Proximal tubulopathy (HP:0000114)2.28661837
75Mitral stenosis (HP:0001718)2.26601753
76Esophageal varix (HP:0002040)2.25837728
77Vomiting (HP:0002013)2.25729912
78Pancreatitis (HP:0001733)2.25558493
79Reduced antithrombin III activity (HP:0001976)2.24605935
80Increased purine levels (HP:0004368)2.24132416
81Hyperuricemia (HP:0002149)2.24132416
82Alkalosis (HP:0001948)2.17835485
83Sensorimotor neuropathy (HP:0007141)2.17818105
84Abnormal gallbladder physiology (HP:0012438)2.17098317
85Cholecystitis (HP:0001082)2.17098317
86Amyloidosis (HP:0011034)2.16261753
87Recurrent gram-negative bacterial infections (HP:0005420)2.12160581
88Abnormal urine phosphate concentration (HP:0012599)2.09775717
89Hydroxyprolinuria (HP:0003080)2.09333416
90Abnormality of proline metabolism (HP:0010907)2.09333416
91Rickets (HP:0002748)2.09311566
92Abnormality of the Achilles tendon (HP:0005109)2.08378828
93Glycosuria (HP:0003076)2.07400400
94Abnormality of urine glucose concentration (HP:0011016)2.07400400
95Thrombophlebitis (HP:0004418)2.06195929
96Gingival bleeding (HP:0000225)2.05027766
97Hyperinsulinemic hypoglycemia (HP:0000825)2.04838921
98Menorrhagia (HP:0000132)2.04216237
99Arthropathy (HP:0003040)2.02241717
100Pulmonary embolism (HP:0002204)2.01942051
101Elevated alkaline phosphatase (HP:0003155)2.01336575
102Opisthotonus (HP:0002179)2.00313893
103Brushfield spots (HP:0001088)1.99768179
104Abnormal enzyme/coenzyme activity (HP:0012379)1.97937513
105Abnormality of the gallbladder (HP:0005264)1.93208322
106Increased mean platelet volume (HP:0011877)1.92317739
107Hemorrhage of the eye (HP:0011885)1.91036115
108Abnormality of alkaline phosphatase activity (HP:0004379)1.91029944
109Hypophosphatemic rickets (HP:0004912)1.90968693
110Poikilocytosis (HP:0004447)1.90327440
111Abnormal cartilage morphology (HP:0002763)1.88589246
112Retinal atrophy (HP:0001105)1.88108264
113Joint swelling (HP:0001386)1.87319662
114Abnormality of transition element cation homeostasis (HP:0011030)1.86902528
115Abnormality of vitamin metabolism (HP:0100508)1.83798675
116Abnormality of iron homeostasis (HP:0011031)1.83257083
117Increased serum ferritin (HP:0003281)1.71445622
118Abnormal platelet volume (HP:0011876)1.70344949
119Neonatal hypoglycemia (HP:0001998)1.67549913
120Abnormal biliary tract physiology (HP:0012439)1.64519490
121Bile duct proliferation (HP:0001408)1.64519490
122Abnormal platelet function (HP:0011869)1.63894595
123Impaired platelet aggregation (HP:0003540)1.63894595
124Hypophosphatemia (HP:0002148)1.60705057
125Hypochromic anemia (HP:0001931)1.58088877
126Generalized hypopigmentation of hair (HP:0011358)1.57291323

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.71887196
2FGFR44.40796119
3ERN14.33545125
4SIK14.06044083
5PASK2.95315754
6INSRR2.88408469
7TAOK32.79329720
8NTRK32.65166499
9ERBB42.61376619
10MAP3K92.30070594
11PKN22.29655836
12MST1R2.22734889
13TRIB32.17702169
14ARAF2.02369744
15MAP3K121.98960796
16MAP2K41.95481443
17MAPK111.84155020
18PRPF4B1.73039639
19PIK3CG1.71351217
20FRK1.68794253
21LATS11.68762946
22CDK121.68146487
23FLT31.67098223
24PTK61.60668219
25MAP3K131.54797112
26TYK21.47929895
27WNK41.44705996
28MAP3K21.44662387
29ABL21.39436870
30STK38L1.36386683
31DAPK21.36044902
32NEK91.27872102
33KSR21.21779134
34MAP3K71.20167222
35KDR1.19823402
36PINK11.19327208
37FGFR21.13678285
38PRKAA21.10966074
39LMTK21.09200110
40JAK21.09188106
41GRK61.04744240
42EPHB11.03282131
43ERBB20.98791968
44MAP2K30.96946346
45NLK0.95876268
46MAP3K30.93534534
47TBK10.90871829
48MET0.90302261
49MAPK150.88959982
50WNK30.88086022
51MAP3K100.87459288
52CDK90.86743380
53PRKCZ0.85840847
54TIE10.85567397
55MAPKAPK30.84677412
56JAK10.82408606
57CSNK1D0.82179267
58DYRK1B0.81222110
59EPHA40.80171035
60MAPK40.78932189
61IRAK30.78283490
62MAPK120.77247025
63PRKG10.76868604
64MAP3K110.75449288
65FER0.74400508
66RIPK10.73539036
67MAP3K140.72889425
68GSK3A0.72679828
69PRKACG0.71309412
70EPHA20.70188794
71PRKAA10.69961611
72PRKACA0.69260331
73OXSR10.68085452
74MAP2K60.67757987
75PTK20.67545788
76NEK60.67268201
77ZAP700.65848172
78EPHA30.65596970
79TGFBR20.65025247
80CAMK2G0.63651211
81SGK30.62610629
82PDK30.61879975
83PDK40.61879975
84CDK60.61802766
85CSK0.59756923
86CSNK1E0.58009241
87TNK20.57492297
88LRRK20.56908110
89MELK0.56313206
90MAP2K20.55913072
91PDPK10.55832752
92CAMK1D0.51914513
93MUSK0.50961402
94NTRK10.50880637
95SGK4940.50579500
96SGK2230.50579500
97MAP2K10.48630914
98RAF10.48179989
99LATS20.45005632
100SGK20.43306828
101FGFR30.43172316
102TAOK20.42688694
103PRKCB0.42611599
104FGFR10.42154804
105MAPK70.42107347
106PRKACB0.42064020
107MTOR0.41308589
108PRKCQ0.41113107
109RPS6KA30.40695678
110GRK10.40457049
111CHUK0.40307202
112MAP3K50.39634504
113PDGFRA0.39409500
114ICK0.38364350
115PIK3CA0.37208641
116SRC0.36795246
117IGF1R0.36722653
118CSNK1G10.36486385
119ACVR1B0.36298164
120CDK40.35894223
121IKBKE0.35368248
122STK240.34215066
123BCR0.34171161
124PKN10.33738015
125NEK10.33123918
126RET0.31706699
127PDK10.31426998
128PAK30.31381803
129CSF1R0.30881698
130CAMK40.29363375
131MYLK0.28646756
132PDK20.28372052
133PRKCG0.27321318
134EGFR0.26786998
135IRAK10.24478805
136STK380.24357516
137IRAK20.24303847
138PRKCA0.24199922
139MAP3K10.24132504
140OBSCN0.22218582

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.28108486
2Nitrogen metabolism_Homo sapiens_hsa009103.45183966
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.37703710
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.37292217
5Arginine biosynthesis_Homo sapiens_hsa002202.95427634
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.73772760
7Tryptophan metabolism_Homo sapiens_hsa003802.67203430
8Complement and coagulation cascades_Homo sapiens_hsa046102.62059331
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.59233240
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.57156581
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.53698942
12Fatty acid degradation_Homo sapiens_hsa000712.53616196
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28531678
14Butanoate metabolism_Homo sapiens_hsa006502.27737536
15Propanoate metabolism_Homo sapiens_hsa006402.11789339
16Peroxisome_Homo sapiens_hsa041462.10435681
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07104946
18Chemical carcinogenesis_Homo sapiens_hsa052041.86226530
19Histidine metabolism_Homo sapiens_hsa003401.85159229
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83506307
21Fatty acid metabolism_Homo sapiens_hsa012121.82573897
22PPAR signaling pathway_Homo sapiens_hsa033201.80886479
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.78751878
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76931223
25beta-Alanine metabolism_Homo sapiens_hsa004101.74521448
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.69026279
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68686485
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.65068455
29Staphylococcus aureus infection_Homo sapiens_hsa051501.62154778
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60298101
31Retinol metabolism_Homo sapiens_hsa008301.58012534
32Selenocompound metabolism_Homo sapiens_hsa004501.56472533
33Caffeine metabolism_Homo sapiens_hsa002321.53591577
34Phenylalanine metabolism_Homo sapiens_hsa003601.52098035
35Bile secretion_Homo sapiens_hsa049761.50404523
36Pyruvate metabolism_Homo sapiens_hsa006201.48769887
37Sulfur metabolism_Homo sapiens_hsa009201.42273746
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41325673
39Fat digestion and absorption_Homo sapiens_hsa049751.36394315
40Tyrosine metabolism_Homo sapiens_hsa003501.34812081
41Starch and sucrose metabolism_Homo sapiens_hsa005001.32891274
42Folate biosynthesis_Homo sapiens_hsa007901.29092099
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.28265494
44Fatty acid elongation_Homo sapiens_hsa000621.28258170
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.27189333
46Biosynthesis of amino acids_Homo sapiens_hsa012301.22898078
47Carbon metabolism_Homo sapiens_hsa012001.22410690
48Steroid biosynthesis_Homo sapiens_hsa001001.21220246
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.14829758
50ABC transporters_Homo sapiens_hsa020101.11938242
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08088706
52Vitamin digestion and absorption_Homo sapiens_hsa049771.06233599
53Arginine and proline metabolism_Homo sapiens_hsa003301.05540298
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02224480
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95322211
56Sulfur relay system_Homo sapiens_hsa041220.91895592
57Vitamin B6 metabolism_Homo sapiens_hsa007500.86534657
58Lysine degradation_Homo sapiens_hsa003100.86071117
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82969264
60Glycerolipid metabolism_Homo sapiens_hsa005610.79446048
61Glutathione metabolism_Homo sapiens_hsa004800.76187507
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76003915
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73773369
64One carbon pool by folate_Homo sapiens_hsa006700.73165368
65Pentose phosphate pathway_Homo sapiens_hsa000300.58248829
66Metabolic pathways_Homo sapiens_hsa011000.48414485
67Fatty acid biosynthesis_Homo sapiens_hsa000610.41984811
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39507109
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30517816
70Fructose and mannose metabolism_Homo sapiens_hsa000510.30426741
71Prion diseases_Homo sapiens_hsa050200.28538734
72Galactose metabolism_Homo sapiens_hsa000520.27731703
73Linoleic acid metabolism_Homo sapiens_hsa005910.23160321
74Insulin resistance_Homo sapiens_hsa049310.22798472
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.20485693
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18382195
77Pertussis_Homo sapiens_hsa051330.18249973
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.12351976
79Glucagon signaling pathway_Homo sapiens_hsa049220.08624231
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.04160641
81AMPK signaling pathway_Homo sapiens_hsa041520.02465470
82N-Glycan biosynthesis_Homo sapiens_hsa00510-0.2284253
83Bladder cancer_Homo sapiens_hsa05219-0.2201813
84African trypanosomiasis_Homo sapiens_hsa05143-0.2077839
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2014514
86Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1906537
87Mineral absorption_Homo sapiens_hsa04978-0.1879278
88TGF-beta signaling pathway_Homo sapiens_hsa04350-0.1853733
89Hepatitis C_Homo sapiens_hsa05160-0.1762513
90Ether lipid metabolism_Homo sapiens_hsa00565-0.1717212
91Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1706837
92Pancreatic secretion_Homo sapiens_hsa04972-0.1572161
93Regulation of autophagy_Homo sapiens_hsa04140-0.1526850
94Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1426410
95Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1368987
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1345104
97Circadian rhythm_Homo sapiens_hsa04710-0.1271405
98Type II diabetes mellitus_Homo sapiens_hsa04930-0.1234254
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1160855
100Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1106996
101Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1086047
102Insulin signaling pathway_Homo sapiens_hsa04910-0.1077507
103Amoebiasis_Homo sapiens_hsa05146-0.1000602
104Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0990932
105Renin-angiotensin system_Homo sapiens_hsa04614-0.0595251
106Sphingolipid metabolism_Homo sapiens_hsa00600-0.0550931
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0543839
108Serotonergic synapse_Homo sapiens_hsa04726-0.0198821
109Other glycan degradation_Homo sapiens_hsa00511-0.0051274
110Protein digestion and absorption_Homo sapiens_hsa04974-0.0051087

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