HACD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a characteristic catalytic motif of the protein tyrosine phosphatases (PTPs) family. The PTP motif of this protein has the highly conserved arginine residue replaced by a proline residue; thus it may represent a distinct class of PTPs. Members of the PTP family are known to be signaling molecules that regulate a variety of cellular processes. This gene was preferentially expressed in both adult and fetal heart. A much lower expression level was detected in skeletal and smooth muscle tissues, and no expression was observed in other tissues. The tissue specific expression in the developing and adult heart suggests a role in regulating cardiac development and differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.68570605
2ATP synthesis coupled proton transport (GO:0015986)5.44651462
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.44651462
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.44353221
5respiratory electron transport chain (GO:0022904)5.10417101
6actin-myosin filament sliding (GO:0033275)5.03178031
7muscle filament sliding (GO:0030049)5.03178031
8electron transport chain (GO:0022900)4.94827796
9actin-mediated cell contraction (GO:0070252)4.56961478
10regulation of mitochondrial translation (GO:0070129)4.23232678
11DNA deamination (GO:0045006)4.20931142
12protein complex biogenesis (GO:0070271)4.14299546
13regulation of skeletal muscle contraction (GO:0014819)4.08732540
14regulation of relaxation of muscle (GO:1901077)4.07989546
15mitochondrial respiratory chain complex I assembly (GO:0032981)4.03482402
16NADH dehydrogenase complex assembly (GO:0010257)4.03482402
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.03482402
18regulation of sarcomere organization (GO:0060297)4.00280965
19sarcomere organization (GO:0045214)3.99853379
20proteasome assembly (GO:0043248)3.93475891
21myofibril assembly (GO:0030239)3.88656054
22mitochondrial respiratory chain complex assembly (GO:0033108)3.73754161
23negative regulation of nitric-oxide synthase activity (GO:0051001)3.72362510
24positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.70778865
25cardiac myofibril assembly (GO:0055003)3.68105840
26GTP biosynthetic process (GO:0006183)3.64690034
27oxidative phosphorylation (GO:0006119)3.63853797
28deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.63729418
29response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.63589639
30heart process (GO:0003015)3.60531742
31heart contraction (GO:0060047)3.60531742
32respiratory chain complex IV assembly (GO:0008535)3.59370170
33branched-chain amino acid catabolic process (GO:0009083)3.52975107
34ubiquinone biosynthetic process (GO:0006744)3.51689381
35quinone biosynthetic process (GO:1901663)3.51689381
36regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.49573818
37preassembly of GPI anchor in ER membrane (GO:0016254)3.44236595
38GPI anchor biosynthetic process (GO:0006506)3.29488942
39L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.26995506
40negative regulation of protein localization to cell surface (GO:2000009)3.26636353
41ubiquinone metabolic process (GO:0006743)3.25474298
42deoxyribonucleotide biosynthetic process (GO:0009263)3.24021972
43cardiac muscle tissue morphogenesis (GO:0055008)3.21112473
44cardiac cell development (GO:0055006)3.17460643
45pseudouridine synthesis (GO:0001522)3.17236357
46cytochrome complex assembly (GO:0017004)3.16362578
47regulation of cell communication by electrical coupling (GO:0010649)3.11383259
48mitochondrial calcium ion homeostasis (GO:0051560)3.10495028
49deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.05660687
50regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.02744267
51cullin deneddylation (GO:0010388)3.00821324
52negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.00060964
53protein targeting to mitochondrion (GO:0006626)2.98101205
54peptidyl-histidine modification (GO:0018202)2.96953102
55regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.94157255
56muscle tissue morphogenesis (GO:0060415)2.93714879
57purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.93695587
58ribosomal small subunit assembly (GO:0000028)2.92231509
59aerobic respiration (GO:0009060)2.91401429
60protein deneddylation (GO:0000338)2.90994239
612-deoxyribonucleotide biosynthetic process (GO:0009265)2.90583055
62deoxyribose phosphate biosynthetic process (GO:0046385)2.90583055
63purine nucleoside triphosphate biosynthetic process (GO:0009145)2.90154772
64response to pheromone (GO:0019236)2.89320135
65daunorubicin metabolic process (GO:0044597)2.88135797
66polyketide metabolic process (GO:0030638)2.88135797
67doxorubicin metabolic process (GO:0044598)2.88135797
68ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.86329952
69RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85545831
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85545831
71regulation of actin filament-based movement (GO:1903115)2.84759054
72pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.84494517
73regulation of the force of heart contraction (GO:0002026)2.84365382
74guanosine-containing compound biosynthetic process (GO:1901070)2.82867307
75GPI anchor metabolic process (GO:0006505)2.82237780
76UTP biosynthetic process (GO:0006228)2.82112210
77actin filament-based movement (GO:0030048)2.81827366
78regulation of cellular amino acid metabolic process (GO:0006521)2.81524847
79pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.79846089
80response to epinephrine (GO:0071871)2.79237946
81negative regulation of transcription by competitive promoter binding (GO:0010944)2.78669990
82pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.78658541
83ventricular cardiac muscle cell development (GO:0055015)2.78449408
84amino acid salvage (GO:0043102)2.77963055
85L-methionine salvage (GO:0071267)2.77963055
86L-methionine biosynthetic process (GO:0071265)2.77963055
87axon ensheathment in central nervous system (GO:0032291)2.77647678
88central nervous system myelination (GO:0022010)2.77647678
89negative regulation of calcium ion transmembrane transport (GO:1903170)2.76513664
90negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.76513664
91rRNA modification (GO:0000154)2.76274318
92regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.75925391
93negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.75475065
94CTP biosynthetic process (GO:0006241)2.74488721
95CTP metabolic process (GO:0046036)2.74488721
96nucleotide transmembrane transport (GO:1901679)2.73582619
97ATP biosynthetic process (GO:0006754)2.73411459
98cardiac muscle contraction (GO:0060048)2.73093862
99regulation of action potential (GO:0098900)2.72870517
100actomyosin structure organization (GO:0031032)2.71871918
101metallo-sulfur cluster assembly (GO:0031163)2.71680074
102iron-sulfur cluster assembly (GO:0016226)2.71680074
103protein heterotetramerization (GO:0051290)2.70558931
104platelet dense granule organization (GO:0060155)2.70284885
105negative regulation of striated muscle cell apoptotic process (GO:0010664)2.67103541
106inner mitochondrial membrane organization (GO:0007007)2.66819549
107positive regulation of action potential (GO:0045760)2.66221445
108water-soluble vitamin biosynthetic process (GO:0042364)2.66090445
109mannosylation (GO:0097502)2.64584781
110branched-chain amino acid metabolic process (GO:0009081)2.64320034
111protein neddylation (GO:0045116)2.63923782
112negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.63081688
113regulation of metalloenzyme activity (GO:0048552)2.61894293
114CENP-A containing nucleosome assembly (GO:0034080)2.61409064
115C-terminal protein lipidation (GO:0006501)2.60665917
116establishment of protein localization to mitochondrion (GO:0072655)2.59703857
117striated muscle contraction (GO:0006941)2.59442170
118positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.59296157
119ribonucleoprotein complex disassembly (GO:0032988)2.58953511
120adenosine metabolic process (GO:0046085)2.57771016
121ribonucleoside triphosphate biosynthetic process (GO:0009201)2.57371543
122regulation of cardioblast differentiation (GO:0051890)2.57295548
123chaperone-mediated protein transport (GO:0072321)2.57110980
124atrial septum morphogenesis (GO:0060413)2.55962435
125mitochondrion morphogenesis (GO:0070584)2.55367120
126regulation of striated muscle contraction (GO:0006942)2.54904814
127protein-cofactor linkage (GO:0018065)2.54581839
128adult heart development (GO:0007512)2.54522686
129regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.54286263
130pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.54250314
131dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.53632429
132regulation of ATP catabolic process (GO:1903289)2.53194436
133regulation of ATPase activity (GO:0043462)2.53194436
134organelle disassembly (GO:1903008)2.52688755
135positive regulation of cardiac muscle cell differentiation (GO:2000727)2.51478351
136UTP metabolic process (GO:0046051)2.51189004
137cardiac muscle cell development (GO:0055013)2.51159821
138positive regulation of actin filament depolymerization (GO:0030836)2.51082338
139nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.50123754
140response to redox state (GO:0051775)2.48795236
141DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.48242239
142tRNA processing (GO:0008033)2.47364004
143ketone body metabolic process (GO:1902224)2.47084937
144exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.46550325
145cellular ketone body metabolic process (GO:0046950)2.45023538

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.58685048
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.44705223
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.18474862
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.05398844
5PCGF2_27294783_Chip-Seq_ESCs_Mouse2.94545119
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.92717141
7PCGF2_27294783_Chip-Seq_NPCs_Mouse2.60929999
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.40833199
9GBX2_23144817_ChIP-Seq_PC3_Human2.39745305
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.39640731
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.34444247
12SRF_21415370_ChIP-Seq_HL-1_Mouse2.27299675
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.25445562
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.24754015
15SUZ12_27294783_Chip-Seq_NPCs_Mouse2.16848441
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.14629987
17NFE2_27457419_Chip-Seq_LIVER_Mouse2.11105221
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.09895029
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02939366
20IGF1R_20145208_ChIP-Seq_DFB_Human1.99186027
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97598386
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95517371
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.90611371
24EZH2_27294783_Chip-Seq_NPCs_Mouse1.89332434
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.85417574
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82015388
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.76936999
28STAT3_18555785_Chip-Seq_ESCs_Mouse1.75743132
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75477622
30EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.72233982
31SUZ12_18555785_Chip-Seq_ESCs_Mouse1.70548955
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69569984
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65981064
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.64982465
35P53_22387025_ChIP-Seq_ESCs_Mouse1.64732673
36MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.58349014
37EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.58138199
38ER_23166858_ChIP-Seq_MCF-7_Human1.57707652
39EP300_21415370_ChIP-Seq_HL-1_Mouse1.57640560
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.55888888
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.55488355
42NMYC_18555785_Chip-Seq_ESCs_Mouse1.52929377
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50942717
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49194484
45P300_18555785_Chip-Seq_ESCs_Mouse1.48678765
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48014879
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47665761
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47306861
49ELK1_19687146_ChIP-ChIP_HELA_Human1.46690036
50CRX_20693478_ChIP-Seq_RETINA_Mouse1.46234345
51E2F1_18555785_Chip-Seq_ESCs_Mouse1.46178199
52ZFX_18555785_Chip-Seq_ESCs_Mouse1.46161699
53FUS_26573619_Chip-Seq_HEK293_Human1.45758841
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45342648
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.44432017
56SOX2_18555785_Chip-Seq_ESCs_Mouse1.43017059
57TP53_22573176_ChIP-Seq_HFKS_Human1.42880983
58EZH2_22144423_ChIP-Seq_EOC_Human1.42264728
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42170780
60ETS1_20019798_ChIP-Seq_JURKAT_Human1.40904897
61RUNX1_27457419_Chip-Seq_LIVER_Mouse1.40536763
62VDR_22108803_ChIP-Seq_LS180_Human1.39990829
63DCP1A_22483619_ChIP-Seq_HELA_Human1.39989124
64OCT4_18555785_Chip-Seq_ESCs_Mouse1.39918617
65KLF4_18555785_Chip-Seq_ESCs_Mouse1.37916713
66PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37428540
67PU1_27457419_Chip-Seq_LIVER_Mouse1.37279849
68CMYC_18555785_Chip-Seq_ESCs_Mouse1.36407656
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.36170313
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35956521
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34811781
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34370398
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.34326673
74IRF1_19129219_ChIP-ChIP_H3396_Human1.33543088
75TAL1_26923725_Chip-Seq_HPCs_Mouse1.32030195
76CJUN_26792858_Chip-Seq_BT549_Human1.31286495
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30913727
78GABP_19822575_ChIP-Seq_HepG2_Human1.30636168
79TRIM28_21343339_ChIP-Seq_HEK293_Human1.30341396
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28769825
81SMAD1_18555785_Chip-Seq_ESCs_Mouse1.27945813
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.27531492
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26892810
84ESRRB_18555785_Chip-Seq_ESCs_Mouse1.24377519
85TAF15_26573619_Chip-Seq_HEK293_Human1.22280101
86SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.21961546
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21719530
88BRD4_25478319_ChIP-Seq_HGPS_Human1.20725860
89CTCF_18555785_Chip-Seq_ESCs_Mouse1.18154801
90SOX2_19829295_ChIP-Seq_ESCs_Human1.17584630
91NANOG_19829295_ChIP-Seq_ESCs_Human1.17584630
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14881329
93EWS_26573619_Chip-Seq_HEK293_Human1.14165017
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13539630
95ELK1_22589737_ChIP-Seq_MCF10A_Human1.12147159
96NFI_21473784_ChIP-Seq_ESCs_Mouse1.12136217
97TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11266785
98LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10738008
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10516808
100FOXP3_21729870_ChIP-Seq_TREG_Human1.09625201
101THAP11_20581084_ChIP-Seq_MESCs_Mouse1.09528719
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09244279
103GATA4_21415370_ChIP-Seq_HL-1_Mouse1.08719806
104MYC_19030024_ChIP-ChIP_MESCs_Mouse1.07245656
105OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06371702
106SMAD4_21799915_ChIP-Seq_A2780_Human1.06337326
107P300_19829295_ChIP-Seq_ESCs_Human1.05677288
108HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05069254
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04176705
110E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03917431
111NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03424946
112NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03424946
113MYC_18940864_ChIP-ChIP_HL60_Human1.03029524
114VDR_23849224_ChIP-Seq_CD4+_Human1.02865781
115CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02161883
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01631545
117PIAS1_25552417_ChIP-Seq_VCAP_Human1.00112574
118FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99164238
119FOXA1_25329375_ChIP-Seq_VCAP_Human0.99164238
120CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99072125
121YY1_21170310_ChIP-Seq_MESCs_Mouse0.98624524
122AR_20517297_ChIP-Seq_VCAP_Human0.98377580
123CBP_20019798_ChIP-Seq_JUKART_Human0.98058272
124IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98058272
125CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97993144
126BCAT_22108803_ChIP-Seq_LS180_Human0.97536353
127ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96041673
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95977834
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95198091
130YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94155476
131E2F4_17652178_ChIP-ChIP_JURKAT_Human0.93101988
132CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92708497
133PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92401189
134UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92324971
135CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92291692
136JUN_21703547_ChIP-Seq_K562_Human0.91761877
137ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90588544
138EOMES_21245162_ChIP-Seq_HESCs_Human0.90117616
139FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89573660
140JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89328719
141MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88997627
142SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88895016
143KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88553988
144OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87723367
145FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87080582

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000749_muscle_degeneration4.40810927
2MP0002102_abnormal_ear_morphology2.98573999
3MP0004215_abnormal_myocardial_fiber2.92087447
4MP0003950_abnormal_plasma_membrane2.84889842
5MP0004084_abnormal_cardiac_muscle2.81706871
6MP0004147_increased_porphyrin_level2.78911939
7MP0000751_myopathy2.70224732
8MP0008438_abnormal_cutaneous_collagen2.62410343
9MP0009379_abnormal_foot_pigmentation2.45925211
10MP0005330_cardiomyopathy2.36879243
11MP0005451_abnormal_body_composition2.33196654
12MP0003646_muscle_fatigue2.31657999
13MP0001188_hyperpigmentation2.30268894
14MP0005171_absent_coat_pigmentation2.30066345
15MP0004036_abnormal_muscle_relaxation2.28908510
16MP0002837_dystrophic_cardiac_calcinosis2.26640413
17MP0000566_synostosis2.16347339
18MP0002972_abnormal_cardiac_muscle2.05038365
19MP0003137_abnormal_impulse_conducting2.03038565
20MP0004145_abnormal_muscle_electrophysio2.02802569
21MP0008775_abnormal_heart_ventricle2.02196813
22MP0005620_abnormal_muscle_contractility1.96430234
23MP0002938_white_spotting1.92468277
24MP0008058_abnormal_DNA_repair1.88261818
25MP0009697_abnormal_copulation1.87400257
26MP0005503_abnormal_tendon_morphology1.86292030
27MP0006036_abnormal_mitochondrial_physio1.81184398
28MP0004484_altered_response_of1.69106808
29MP0003136_yellow_coat_color1.68107455
30MP0002106_abnormal_muscle_physiology1.64663986
31MP0010368_abnormal_lymphatic_system1.63219224
32MP0004087_abnormal_muscle_fiber1.60869984
33MP0000750_abnormal_muscle_regeneration1.60807523
34MP0002132_abnormal_respiratory_system1.53521925
35MP0002234_abnormal_pharynx_morphology1.49745970
36MP0005369_muscle_phenotype1.49726371
37MP0006072_abnormal_retinal_apoptosis1.47828917
38MP0004272_abnormal_basement_membrane1.47675094
39MP0000759_abnormal_skeletal_muscle1.45118939
40MP0003279_aneurysm1.44615134
41MP0000372_irregular_coat_pigmentation1.44194774
42MP0009250_abnormal_appendicular_skeleto1.40702990
43MP0006292_abnormal_olfactory_placode1.38039120
44MP0001529_abnormal_vocalization1.33761725
45MP0004134_abnormal_chest_morphology1.30722960
46MP0003221_abnormal_cardiomyocyte_apopto1.26866070
47MP0003718_maternal_effect1.25932169
48MP0010030_abnormal_orbit_morphology1.22210463
49MP0008004_abnormal_stomach_pH1.21823738
50MP0000747_muscle_weakness1.21671508
51MP0005670_abnormal_white_adipose1.19955990
52MP0001544_abnormal_cardiovascular_syste1.19475446
53MP0005385_cardiovascular_system_phenoty1.19475446
54MP0002269_muscular_atrophy1.19269895
55MP0002396_abnormal_hematopoietic_system1.18799916
56MP0000015_abnormal_ear_pigmentation1.18653880
57MP0001661_extended_life_span1.18349787
58MP0002127_abnormal_cardiovascular_syste1.17481054
59MP0003828_pulmonary_edema1.16415342
60MP0001485_abnormal_pinna_reflex1.15565876
61MP0010630_abnormal_cardiac_muscle1.11614156
62MP0003186_abnormal_redox_activity1.11121507
63MP0004142_abnormal_muscle_tone1.10457269
64MP0006035_abnormal_mitochondrial_morpho1.08130832
65MP0002638_abnormal_pupillary_reflex1.08083641
66MP0000462_abnormal_digestive_system1.04675645
67MP0003806_abnormal_nucleotide_metabolis1.00926656
68MP0002277_abnormal_respiratory_mucosa1.00181946
69MP0003567_abnormal_fetal_cardiomyocyte0.99728725
70MP0006138_congestive_heart_failure0.96554461
71MP0000762_abnormal_tongue_morphology0.96403105
72MP0002160_abnormal_reproductive_system0.96372966
73MP0000049_abnormal_middle_ear0.95953954
74MP0004085_abnormal_heartbeat0.95900616
75MP0006276_abnormal_autonomic_nervous0.94223708
76MP0003941_abnormal_skin_development0.94037400
77MP0005410_abnormal_fertilization0.93467347
78MP0003786_premature_aging0.92377603
79MP0005409_darkened_coat_color0.92341842
80MP0004381_abnormal_hair_follicle0.91924056
81MP0009384_cardiac_valve_regurgitation0.91654762
82MP0000230_abnormal_systemic_arterial0.91056915
83MP0004233_abnormal_muscle_weight0.91006709
84MP0008872_abnormal_physiological_respon0.88774549
85MP0000490_abnormal_crypts_of0.88445497
86MP0005253_abnormal_eye_physiology0.87376965
87MP0002108_abnormal_muscle_morphology0.86615767
88MP0000343_altered_response_to0.85331589
89MP0002736_abnormal_nociception_after0.84509708
90MP0005646_abnormal_pituitary_gland0.81447669
91MP0005174_abnormal_tail_pigmentation0.81258180
92MP0001986_abnormal_taste_sensitivity0.81243277
93MP0005075_abnormal_melanosome_morpholog0.80277594
94MP0004133_heterotaxia0.79241983
95MP0004742_abnormal_vestibular_system0.78655654
96MP0002095_abnormal_skin_pigmentation0.78301153
97MP0010386_abnormal_urinary_bladder0.77113520
98MP0001968_abnormal_touch/_nociception0.77110190
99MP0000026_abnormal_inner_ear0.76895065
100MP0010094_abnormal_chromosome_stability0.76544015
101MP0008007_abnormal_cellular_replicative0.76431929
102MP0005551_abnormal_eye_electrophysiolog0.75871768
103MP0002163_abnormal_gland_morphology0.75761415
104MP0005508_abnormal_skeleton_morphology0.75561131
105MP0005623_abnormal_meninges_morphology0.74470690
106MP0000013_abnormal_adipose_tissue0.74377439
107MP0005165_increased_susceptibility_to0.72277904
108MP0001542_abnormal_bone_strength0.71674595
109MP0003195_calcinosis0.71495135
110MP0000569_abnormal_digit_pigmentation0.70919517
111MP0008789_abnormal_olfactory_epithelium0.70902171
112MP0008932_abnormal_embryonic_tissue0.70666609
113MP0005084_abnormal_gallbladder_morpholo0.70371707
114MP0001905_abnormal_dopamine_level0.70253433
115MP0000358_abnormal_cell_content/0.70183568
116MP0002254_reproductive_system_inflammat0.70183436
117MP0005257_abnormal_intraocular_pressure0.70139693
118MP0003937_abnormal_limbs/digits/tail_de0.69515402
119MP0005266_abnormal_metabolism0.69257635
120MP0000266_abnormal_heart_morphology0.67807368
121MP0001984_abnormal_olfaction0.67257221
122MP0005595_abnormal_vascular_smooth0.66784963
123MP0005377_hearing/vestibular/ear_phenot0.66444535
124MP0003878_abnormal_ear_physiology0.66444535
125MP0000427_abnormal_hair_cycle0.66066552
126MP0009780_abnormal_chondrocyte_physiolo0.65354188
127MP0001299_abnormal_eye_distance/0.64398537
128MP0002332_abnormal_exercise_endurance0.63754480
129MP0000920_abnormal_myelination0.63740583
130MP0000163_abnormal_cartilage_morphology0.63666350
131MP0006054_spinal_hemorrhage0.61784804
132MP0005332_abnormal_amino_acid0.61302235
133MP0002877_abnormal_melanocyte_morpholog0.58893330
134MP0002128_abnormal_blood_circulation0.58613336
135MP0005389_reproductive_system_phenotype0.58114589

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.66645002
2Abnormal mitochondria in muscle tissue (HP:0008316)4.29792688
3Mitochondrial inheritance (HP:0001427)4.28197978
4Hepatic necrosis (HP:0002605)3.94905130
5Hepatocellular necrosis (HP:0001404)3.91738344
6Progressive macrocephaly (HP:0004481)3.91043797
7Increased CSF lactate (HP:0002490)3.75702585
8Acute encephalopathy (HP:0006846)3.66389475
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.64201512
10Abnormality of alanine metabolism (HP:0010916)3.44265209
11Hyperalaninemia (HP:0003348)3.44265209
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.44265209
13Increased hepatocellular lipid droplets (HP:0006565)3.41097478
14Atrial fibrillation (HP:0005110)3.38587815
15Bundle branch block (HP:0011710)3.37396208
16Chromsome breakage (HP:0040012)3.36336727
17Calf muscle hypertrophy (HP:0008981)3.35865663
18Muscle hypertrophy of the lower extremities (HP:0008968)3.33565936
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.29451159
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.29451159
21Nemaline bodies (HP:0003798)3.25727146
22Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.23659468
23Exercise intolerance (HP:0003546)3.21140239
243-Methylglutaconic aciduria (HP:0003535)3.21046879
25Renal Fanconi syndrome (HP:0001994)3.18826571
26Lipid accumulation in hepatocytes (HP:0006561)3.16639496
27Muscle fiber inclusion bodies (HP:0100299)3.09972875
28Supraventricular tachycardia (HP:0004755)3.07540917
29Increased serum lactate (HP:0002151)3.06655007
30Lipoatrophy (HP:0100578)3.05106010
31Ventricular tachycardia (HP:0004756)3.03400138
32Primary atrial arrhythmia (HP:0001692)3.01393591
33Microvesicular hepatic steatosis (HP:0001414)2.96921236
34Supraventricular arrhythmia (HP:0005115)2.95721482
35Sudden death (HP:0001699)2.93701323
36Abnormality of the calf musculature (HP:0001430)2.92414697
37Congenital sensorineural hearing impairment (HP:0008527)2.92322278
38Lactic acidosis (HP:0003128)2.90728265
39Prolonged QT interval (HP:0001657)2.89376761
40Increased serum pyruvate (HP:0003542)2.88460157
41Abnormality of glycolysis (HP:0004366)2.88460157
42Distal lower limb muscle weakness (HP:0009053)2.87643976
43Areflexia of lower limbs (HP:0002522)2.85883807
44Distal arthrogryposis (HP:0005684)2.85117282
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.84459855
46Hyporeflexia of lower limbs (HP:0002600)2.82792663
47Dilated cardiomyopathy (HP:0001644)2.75836798
48Duplicated collecting system (HP:0000081)2.70363512
49Cerebral edema (HP:0002181)2.68138184
50Abnormality of DNA repair (HP:0003254)2.65826159
51Respiratory failure (HP:0002878)2.62762583
52Type 1 muscle fiber predominance (HP:0003803)2.62512080
53Increased intramyocellular lipid droplets (HP:0012240)2.59381252
54Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.59211050
55Abnormal protein N-linked glycosylation (HP:0012347)2.59211050
56Abnormal protein glycosylation (HP:0012346)2.59211050
57Abnormal glycosylation (HP:0012345)2.59211050
58Exercise-induced myalgia (HP:0003738)2.57674499
59Renal cortical cysts (HP:0000803)2.56366462
60Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.54889862
61Pancreatic fibrosis (HP:0100732)2.54468129
62Reticulocytopenia (HP:0001896)2.53803357
63Optic disc pallor (HP:0000543)2.50786256
64Subaortic stenosis (HP:0001682)2.49138001
65Abnormality of the left ventricular outflow tract (HP:0011103)2.49138001
66Abnormality of the renal collecting system (HP:0004742)2.42610635
67Muscle fiber splitting (HP:0003555)2.41328418
68Exercise-induced muscle cramps (HP:0003710)2.38973415
69Asymmetric septal hypertrophy (HP:0001670)2.37163925
70Exertional dyspnea (HP:0002875)2.33319652
71Pancreatic cysts (HP:0001737)2.31075037
72Abnormality of midbrain morphology (HP:0002418)2.30532461
73Molar tooth sign on MRI (HP:0002419)2.30532461
74EMG: myopathic abnormalities (HP:0003458)2.28326283
75Abnormality of placental membranes (HP:0011409)2.26802249
76Amniotic constriction ring (HP:0009775)2.26802249
77Methylmalonic acidemia (HP:0002912)2.26694639
78Palpitations (HP:0001962)2.24741647
79Myotonia (HP:0002486)2.24646769
80Generalized aminoaciduria (HP:0002909)2.24614713
81Abnormality of the preputium (HP:0100587)2.24273596
82Delayed gross motor development (HP:0002194)2.24032038
83Increased muscle lipid content (HP:0009058)2.23124794
84Abnormal number of erythroid precursors (HP:0012131)2.22740121
85Abnormal EKG (HP:0003115)2.21761481
86Abnormality of the renal cortex (HP:0011035)2.21403832
87Absent phalangeal crease (HP:0006109)2.13011884
88Patchy hypopigmentation of hair (HP:0011365)2.11723565
89Facial diplegia (HP:0001349)2.10111365
90Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.10085317
91Neck muscle weakness (HP:0000467)2.09764413
92Poikiloderma (HP:0001029)2.07084689
93Hypoplastic heart (HP:0001961)2.06107091
94Abnormality of the heme biosynthetic pathway (HP:0010472)2.05540700
95Abnormality of renal resorption (HP:0011038)2.04962133
96Pulmonary artery stenosis (HP:0004415)2.04403689
97Leukodystrophy (HP:0002415)2.04335023
98Type 2 muscle fiber atrophy (HP:0003554)2.03002274
99Methylmalonic aciduria (HP:0012120)2.02516898
100Glycosuria (HP:0003076)2.01484706
101Abnormality of urine glucose concentration (HP:0011016)2.01484706
102Medial flaring of the eyebrow (HP:0010747)2.01402972
103Rimmed vacuoles (HP:0003805)2.01259550
104Aplasia/Hypoplasia involving the musculature (HP:0001460)2.00084519
105Ileus (HP:0002595)1.99970084
106Round ear (HP:0100830)1.97241373
107Heart block (HP:0012722)1.96309012
108Abnormality of cells of the erythroid lineage (HP:0012130)1.95878991
109Reduced antithrombin III activity (HP:0001976)1.95157131
110Aplasia/Hypoplasia of the sacrum (HP:0008517)1.93344406
111Syncope (HP:0001279)1.93287259
112Type I transferrin isoform profile (HP:0003642)1.92471014
113Aplasia/Hypoplasia of the fovea (HP:0008060)1.92189469
114Hypoplasia of the fovea (HP:0007750)1.92189469
115Abnormal atrioventricular conduction (HP:0005150)1.91387994
116Aplasia of the musculature (HP:0100854)1.90597021
117True hermaphroditism (HP:0010459)1.90157019
118Premature rupture of membranes (HP:0001788)1.88978015
119Lethargy (HP:0001254)1.88734424
120Muscle fiber atrophy (HP:0100295)1.88329157
121Myoglobinuria (HP:0002913)1.85414743
122Hypoplastic left heart (HP:0004383)1.84956597
123Aplasia/Hypoplasia of the tibia (HP:0005772)1.84410306
124Opisthotonus (HP:0002179)1.83821227
125Metaphyseal dysplasia (HP:0100255)1.83352136
126Aplasia/Hypoplasia of the uvula (HP:0010293)1.83262574
127Rhabdomyolysis (HP:0003201)1.82429840
128Abnormal finger flexion creases (HP:0006143)1.81319131
129Gowers sign (HP:0003391)1.81008554
130Ventricular arrhythmia (HP:0004308)1.80940164
131White forelock (HP:0002211)1.80055825
132Cerebellar dysplasia (HP:0007033)1.79966405
133Upper limb muscle weakness (HP:0003484)1.79865536
134Weak cry (HP:0001612)1.79233065
135Duplication of thumb phalanx (HP:0009942)1.78092623
136Left ventricular hypertrophy (HP:0001712)1.77431161
137Retinal dysplasia (HP:0007973)1.77132867
138Prostate neoplasm (HP:0100787)1.75936720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN3.71135505
2STK163.43145558
3VRK23.15060867
4ZAK3.13328183
5NME22.71026941
6MUSK2.62322668
7MAP3K122.57437164
8MAP4K22.56538747
9FRK2.55727758
10MYLK2.49176506
11PIK3CA2.39674991
12EIF2AK22.36209562
13FLT32.33279980
14PIK3CG2.18471863
15STK392.10255122
16CASK2.09174538
17LIMK12.05882572
18EIF2AK11.91000471
19PBK1.90493816
20MAPKAPK31.88719601
21TNIK1.82406090
22NUAK11.76896074
23NEK11.64219048
24MKNK11.61542082
25TRPM71.56721217
26VRK11.55715804
27IRAK31.53134010
28STK38L1.50997381
29PIM21.48905804
30NME11.47064904
31LMTK21.45867286
32TAF11.45625897
33TLK11.42072486
34BMPR1B1.41410260
35TTN1.38468726
36SCYL21.37748084
37WNK31.36120083
38PHKG21.32637253
39PHKG11.32637253
40MST41.31690549
41EIF2AK31.24590073
42CSNK1G31.21209861
43MKNK21.20784378
44CDK81.19374235
45CCNB11.19279397
46CSNK1G11.12194092
47INSRR1.10204439
48PINK11.09452256
49IRAK41.08339358
50ADRBK21.07901744
51CAMK2D1.05626035
52TEC1.04486576
53CSNK1A1L1.03761381
54NEK61.03614815
55STK241.03145715
56BCR1.02997104
57DYRK21.02291533
58PKN11.00531777
59PLK30.99646238
60TAOK30.99556691
61PLK40.98467719
62PAK30.98247383
63OXSR10.94997278
64DMPK0.93666547
65GRK10.93277016
66TIE10.93240989
67MAP2K70.92417765
68YES10.92333763
69CSNK1G20.92224705
70ABL20.92067876
71STK40.88904562
72IRAK20.88119167
73MAPKAPK50.88023521
74PRPF4B0.86380428
75DAPK10.86223525
76PLK20.82970132
77TESK10.82321200
78TXK0.81811785
79CLK10.79924040
80PDK20.79547763
81ADRBK10.79173003
82GRK70.79032557
83ROCK10.78835989
84RPS6KA50.76634659
85SRPK10.73805516
86DYRK30.73555677
87BCKDK0.72840684
88ILK0.71322396
89PRKG20.68929534
90ERBB30.68784970
91KIT0.68547754
92BUB10.67891600
93DAPK30.66221847
94PDK40.66030581
95PDK30.66030581
96FER0.64400534
97KDR0.59988744
98RPS6KA40.58255186
99MAPK130.58234027
100LATS10.58160655
101WNK40.58133890
102AURKB0.57485437
103CDK190.55322975
104PRKG10.54940627
105MAP3K50.54520088
106NEK90.53742632
107PAK20.53408329
108TRIM280.52978953
109EPHB20.52307730
110ERBB40.50264626
111ROCK20.50098775
112STK30.49618851
113TTK0.49603741
114PRKCE0.49484230
115CDC42BPA0.48858848
116ATR0.47009881
117MET0.44368729
118CAMK2G0.44367698
119PLK10.44273006
120CDC70.43795890
121CAMK2A0.43109232
122IRAK10.42641705
123PRKAA20.41970701
124AURKA0.41795127
125CHEK20.41396823
126CDK70.40187233
127WEE10.39439013
128MAP3K110.38348028
129MAP2K10.38083614
130MAPK120.37955650
131TAOK20.37858618
132CSNK2A10.37230335
133CAMK2B0.37065212
134BRSK20.37028514
135PTK2B0.35598730
136MOS0.35320311
137WNK10.34654238
138PRKACA0.34311000
139MAP3K70.32615408
140PRKCI0.32075509

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.29317167
2Parkinsons disease_Homo sapiens_hsa050124.09534966
3Ribosome_Homo sapiens_hsa030103.20641368
4Cardiac muscle contraction_Homo sapiens_hsa042603.07294264
5Huntingtons disease_Homo sapiens_hsa050163.02533790
6Alzheimers disease_Homo sapiens_hsa050102.89233547
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.61551072
8Protein export_Homo sapiens_hsa030602.54610742
9Homologous recombination_Homo sapiens_hsa034402.37123089
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.32944071
11DNA replication_Homo sapiens_hsa030302.29633586
12RNA polymerase_Homo sapiens_hsa030202.18364539
13Selenocompound metabolism_Homo sapiens_hsa004502.17487438
14Proteasome_Homo sapiens_hsa030502.10730825
15Fanconi anemia pathway_Homo sapiens_hsa034602.10241909
16Mismatch repair_Homo sapiens_hsa034302.09091023
17Nucleotide excision repair_Homo sapiens_hsa034202.02924270
18Fatty acid elongation_Homo sapiens_hsa000621.97022363
19Pyrimidine metabolism_Homo sapiens_hsa002401.90279655
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.86857990
21Non-homologous end-joining_Homo sapiens_hsa034501.80399833
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.69064493
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58665735
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58544563
25Dilated cardiomyopathy_Homo sapiens_hsa054141.54188693
26Base excision repair_Homo sapiens_hsa034101.54083573
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53103173
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.49119571
29Propanoate metabolism_Homo sapiens_hsa006401.47477773
30Arachidonic acid metabolism_Homo sapiens_hsa005901.43428015
31Basal transcription factors_Homo sapiens_hsa030221.41576335
32Purine metabolism_Homo sapiens_hsa002301.41345099
33Steroid biosynthesis_Homo sapiens_hsa001001.29724594
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27092548
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.27090637
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24627285
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22428849
38One carbon pool by folate_Homo sapiens_hsa006701.16232399
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.15983837
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05245071
41Linoleic acid metabolism_Homo sapiens_hsa005911.04257067
42Nitrogen metabolism_Homo sapiens_hsa009101.03884862
43Sphingolipid metabolism_Homo sapiens_hsa006001.03520653
44Tryptophan metabolism_Homo sapiens_hsa003801.02868322
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02615134
46Glutathione metabolism_Homo sapiens_hsa004801.00393696
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98631878
48Sulfur metabolism_Homo sapiens_hsa009200.97040505
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97007550
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95586705
51Ether lipid metabolism_Homo sapiens_hsa005650.95455107
52Metabolic pathways_Homo sapiens_hsa011000.94652659
53Arginine and proline metabolism_Homo sapiens_hsa003300.92104379
54Regulation of autophagy_Homo sapiens_hsa041400.91429649
55RNA degradation_Homo sapiens_hsa030180.90930363
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84881743
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83294319
58ECM-receptor interaction_Homo sapiens_hsa045120.83013667
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82386961
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79481906
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75389715
62Folate biosynthesis_Homo sapiens_hsa007900.70577518
63Carbon metabolism_Homo sapiens_hsa012000.66901880
64Spliceosome_Homo sapiens_hsa030400.63548444
65Circadian rhythm_Homo sapiens_hsa047100.62229158
66Fatty acid degradation_Homo sapiens_hsa000710.59129360
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57677498
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.57274674
69Protein digestion and absorption_Homo sapiens_hsa049740.56961302
70Systemic lupus erythematosus_Homo sapiens_hsa053220.56801195
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56141424
72Cell cycle_Homo sapiens_hsa041100.55673355
73Pyruvate metabolism_Homo sapiens_hsa006200.55535390
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55478605
75Peroxisome_Homo sapiens_hsa041460.52847533
76Calcium signaling pathway_Homo sapiens_hsa040200.52636572
77beta-Alanine metabolism_Homo sapiens_hsa004100.52378241
78Vitamin digestion and absorption_Homo sapiens_hsa049770.52250919
79p53 signaling pathway_Homo sapiens_hsa041150.50356454
80Chemical carcinogenesis_Homo sapiens_hsa052040.49872378
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49575969
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47727071
83Viral myocarditis_Homo sapiens_hsa054160.47719397
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47144717
85Hematopoietic cell lineage_Homo sapiens_hsa046400.46790521
86Malaria_Homo sapiens_hsa051440.45806615
87Olfactory transduction_Homo sapiens_hsa047400.43545445
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42813656
89Tyrosine metabolism_Homo sapiens_hsa003500.42602845
90Fatty acid metabolism_Homo sapiens_hsa012120.41252226
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40669964
92TGF-beta signaling pathway_Homo sapiens_hsa043500.40546187
93Other glycan degradation_Homo sapiens_hsa005110.39861451
94Taste transduction_Homo sapiens_hsa047420.39764808
95Ovarian steroidogenesis_Homo sapiens_hsa049130.38641359
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38437838
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37340093
98N-Glycan biosynthesis_Homo sapiens_hsa005100.36909987
99Starch and sucrose metabolism_Homo sapiens_hsa005000.36105942
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35905254
101Salivary secretion_Homo sapiens_hsa049700.34557024
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31930788
103Autoimmune thyroid disease_Homo sapiens_hsa053200.31764138
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30640088
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30458186
106RNA transport_Homo sapiens_hsa030130.29800196
107Caffeine metabolism_Homo sapiens_hsa002320.29089801
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28442280
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27856666
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27355491
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26400562
112Retinol metabolism_Homo sapiens_hsa008300.25091212
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23802782
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.23497994
115Sulfur relay system_Homo sapiens_hsa041220.22890813
116Pentose phosphate pathway_Homo sapiens_hsa000300.21931247
117Butanoate metabolism_Homo sapiens_hsa006500.18481518
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.15200234
119Galactose metabolism_Homo sapiens_hsa000520.14162207
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.12893989
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12045143
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.11273427
123Epstein-Barr virus infection_Homo sapiens_hsa051690.10659052
124Histidine metabolism_Homo sapiens_hsa003400.10384696
125Small cell lung cancer_Homo sapiens_hsa052220.09890521
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.09870397
127Tight junction_Homo sapiens_hsa045300.08941603
128Herpes simplex infection_Homo sapiens_hsa051680.08885237
129Phototransduction_Homo sapiens_hsa047440.06427525
130Phagosome_Homo sapiens_hsa041450.04115065

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