HACD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene can catalyze the third step (dehydration) in the conversion of long chain fatty acids to very long chain fatty acids. The encoded protein localizes to the endoplasmic reticulum membrane. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)8.28310673
2desmosome organization (GO:0002934)7.06148597
3alpha-linolenic acid metabolic process (GO:0036109)5.66402235
4triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.64185838
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.54243287
6L-phenylalanine catabolic process (GO:0006559)5.54243287
7bundle of His cell to Purkinje myocyte communication (GO:0086069)5.37349459
8sulfur amino acid catabolic process (GO:0000098)5.33609679
9L-phenylalanine metabolic process (GO:0006558)5.33385099
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.33385099
11cysteine metabolic process (GO:0006534)4.95892106
12branched-chain amino acid catabolic process (GO:0009083)4.76216639
13biotin metabolic process (GO:0006768)4.63225977
14valine metabolic process (GO:0006573)4.59150414
15regulation of triglyceride catabolic process (GO:0010896)4.58856297
16aromatic amino acid family catabolic process (GO:0009074)4.52256413
17fatty-acyl-CoA biosynthetic process (GO:0046949)4.51465470
18long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.50953816
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.35473081
20branched-chain amino acid metabolic process (GO:0009081)4.34454296
21plasma lipoprotein particle clearance (GO:0034381)4.27723476
22regulation of cholesterol esterification (GO:0010872)4.27492375
23complement activation, alternative pathway (GO:0006957)4.22517117
24short-chain fatty acid metabolic process (GO:0046459)4.22453473
25fatty acid elongation (GO:0030497)4.22296790
26glyoxylate metabolic process (GO:0046487)4.21502581
27amino-acid betaine metabolic process (GO:0006577)4.21495185
28fatty-acyl-CoA metabolic process (GO:0035337)4.20404474
29protein-lipid complex remodeling (GO:0034368)4.19801704
30macromolecular complex remodeling (GO:0034367)4.19801704
31plasma lipoprotein particle remodeling (GO:0034369)4.19801704
32intestinal epithelial cell development (GO:0060576)4.19292918
33thioester biosynthetic process (GO:0035384)4.17990963
34acyl-CoA biosynthetic process (GO:0071616)4.17990963
35fatty acid beta-oxidation (GO:0006635)4.16554296
36bile acid biosynthetic process (GO:0006699)4.15774012
37cell-substrate junction assembly (GO:0007044)4.12257337
38high-density lipoprotein particle remodeling (GO:0034375)4.09602849
39regulation of sequestering of triglyceride (GO:0010889)4.07925472
40ethanol oxidation (GO:0006069)4.06955476
41cell adhesion mediated by integrin (GO:0033627)4.06519236
42lipid oxidation (GO:0034440)4.05674664
43low-density lipoprotein particle clearance (GO:0034383)4.03177610
44fatty acid oxidation (GO:0019395)4.02674495
45long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.02453881
46triglyceride catabolic process (GO:0019433)4.00453059
47triglyceride biosynthetic process (GO:0019432)3.96447270
48serine family amino acid catabolic process (GO:0009071)3.96437064
49neutral lipid biosynthetic process (GO:0046460)3.95308546
50acylglycerol biosynthetic process (GO:0046463)3.95308546
51very long-chain fatty acid metabolic process (GO:0000038)3.92210588
52low-density lipoprotein particle remodeling (GO:0034374)3.86945495
53neutral lipid catabolic process (GO:0046461)3.85796425
54acylglycerol catabolic process (GO:0046464)3.85796425
55negative regulation of keratinocyte proliferation (GO:0010839)3.83571903
56serine family amino acid biosynthetic process (GO:0009070)3.82929230
57gap junction assembly (GO:0016264)3.82331733
58reverse cholesterol transport (GO:0043691)3.82064354
59carnitine metabolic process (GO:0009437)3.81553414
60fatty acid catabolic process (GO:0009062)3.79915248
61homocysteine metabolic process (GO:0050667)3.77809011
62triglyceride homeostasis (GO:0070328)3.75994882
63acylglycerol homeostasis (GO:0055090)3.75994882
64L-serine metabolic process (GO:0006563)3.75641599
65acetyl-CoA metabolic process (GO:0006084)3.74054165
66very-low-density lipoprotein particle assembly (GO:0034379)3.73589319
67heme transport (GO:0015886)3.71236604
68cellular amino acid catabolic process (GO:0009063)3.70870411
69lysine metabolic process (GO:0006553)3.69752583
70lysine catabolic process (GO:0006554)3.69752583
71positive regulation of fatty acid beta-oxidation (GO:0032000)3.68433491
72tryptophan catabolic process (GO:0006569)3.68099287
73indole-containing compound catabolic process (GO:0042436)3.68099287
74indolalkylamine catabolic process (GO:0046218)3.68099287
75serine family amino acid metabolic process (GO:0009069)3.66859364
76positive regulation of fatty acid oxidation (GO:0046321)3.66389511
77cellular modified amino acid catabolic process (GO:0042219)3.66052726
78negative regulation of lipase activity (GO:0060192)3.64235138
79alpha-amino acid catabolic process (GO:1901606)3.63749353
80regulation of protein activation cascade (GO:2000257)3.61788307
81triglyceride metabolic process (GO:0006641)3.58689155
82positive regulation of triglyceride metabolic process (GO:0090208)3.58395580
83acyl-CoA metabolic process (GO:0006637)3.58285619
84thioester metabolic process (GO:0035383)3.58285619
85linoleic acid metabolic process (GO:0043651)3.54418262
86monocarboxylic acid catabolic process (GO:0072329)3.53993392
87positive regulation of lipid catabolic process (GO:0050996)3.51778975
88bile acid metabolic process (GO:0008206)3.49394168
89regulation of cholesterol biosynthetic process (GO:0045540)3.49271620
90ethanol metabolic process (GO:0006067)3.49146811
91carboxylic acid catabolic process (GO:0046395)3.48447185
92organic acid catabolic process (GO:0016054)3.48447185
93regulation of complement activation (GO:0030449)3.44813725
94kynurenine metabolic process (GO:0070189)3.44189232
95tryptophan metabolic process (GO:0006568)3.44142549
96plasma lipoprotein particle organization (GO:0071827)3.44046073
97plasma lipoprotein particle assembly (GO:0034377)3.42908119
98negative regulation of cholesterol transport (GO:0032375)3.42370011
99negative regulation of sterol transport (GO:0032372)3.42370011
100phospholipid efflux (GO:0033700)3.41078627
101protein carboxylation (GO:0018214)3.38247615
102peptidyl-glutamic acid carboxylation (GO:0017187)3.38247615
103regulation of cholesterol metabolic process (GO:0090181)3.38136189
104acylglycerol metabolic process (GO:0006639)3.37611844
105negative regulation of fibrinolysis (GO:0051918)3.36831282
106regulation of transforming growth factor beta2 production (GO:0032909)3.36693737
107regulation of triglyceride metabolic process (GO:0090207)3.36419609
108urea cycle (GO:0000050)3.33352167
109urea metabolic process (GO:0019627)3.33352167
110cellular glucuronidation (GO:0052695)3.30342600
111regulation of water loss via skin (GO:0033561)3.20115032
112L-serine transport (GO:0015825)3.17375662
113regulation of hippo signaling (GO:0035330)3.11226582
114regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.08809367
115daunorubicin metabolic process (GO:0044597)3.04934121
116polyketide metabolic process (GO:0030638)3.04934121
117doxorubicin metabolic process (GO:0044598)3.04934121
118regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.97691368
119uronic acid metabolic process (GO:0006063)2.97323033
120glucuronate metabolic process (GO:0019585)2.97323033
121regulation of fibrinolysis (GO:0051917)2.94279741
122keratinocyte proliferation (GO:0043616)2.92656642
123intestinal cholesterol absorption (GO:0030299)2.91474800
124regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.83038627
125iron ion import (GO:0097286)2.82590687
126establishment of skin barrier (GO:0061436)2.81982563
127regulation of keratinocyte proliferation (GO:0010837)2.79053118
128nitrogen cycle metabolic process (GO:0071941)2.75802072
129dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.73853005
130polarized epithelial cell differentiation (GO:0030859)2.73844158
131insulin-like growth factor receptor signaling pathway (GO:0048009)2.73620135
132fatty acid homeostasis (GO:0055089)2.69369840
133aminoglycoside antibiotic metabolic process (GO:0030647)2.69248392
134regulation of cholesterol homeostasis (GO:2000188)2.68575767
135drug transmembrane transport (GO:0006855)2.66973359
136Golgi transport vesicle coating (GO:0048200)2.66614510
137COPI coating of Golgi vesicle (GO:0048205)2.66614510
138tight junction assembly (GO:0070830)2.66500806
139cell-substrate adherens junction assembly (GO:0007045)2.65300604
140focal adhesion assembly (GO:0048041)2.65300604
141ER overload response (GO:0006983)2.64590851
142regulation of plasminogen activation (GO:0010755)2.60826952
143regulation of fatty acid beta-oxidation (GO:0031998)2.57109321
144maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.55453321
145positive regulation of keratinocyte differentiation (GO:0045618)2.55308765
146intestinal absorption (GO:0050892)2.54853772
147COPII vesicle coating (GO:0048208)2.54804634
148negative regulation of fatty acid transport (GO:2000192)2.54766488
149endodermal cell differentiation (GO:0035987)2.53251679
150surfactant homeostasis (GO:0043129)2.51100454
151carnitine shuttle (GO:0006853)2.51078591
152epithelial cell-cell adhesion (GO:0090136)2.49086320
153notochord development (GO:0030903)2.41204871
154multicellular organismal water homeostasis (GO:0050891)2.40512099
155fatty acid transmembrane transport (GO:1902001)2.40257037
156adherens junction assembly (GO:0034333)2.37695974
157branching involved in mammary gland duct morphogenesis (GO:0060444)2.36175690
158regulation of glucose import in response to insulin stimulus (GO:2001273)2.36099160
159serine transport (GO:0032329)2.35696914
160UDP-N-acetylglucosamine metabolic process (GO:0006047)2.33704998
161chemical homeostasis within a tissue (GO:0048875)2.32526141
162activation of Rac GTPase activity (GO:0032863)2.32486722
163positive regulation of epidermal cell differentiation (GO:0045606)2.32356431
164primary alcohol catabolic process (GO:0034310)2.31282052
165cell junction assembly (GO:0034329)2.30387609
166regulation of keratinocyte differentiation (GO:0045616)2.30290405
167protein retention in ER lumen (GO:0006621)2.29909897
168cell-cell junction assembly (GO:0007043)2.29379834
169fibrinolysis (GO:0042730)2.28242588
170mammary gland epithelial cell proliferation (GO:0033598)2.26084086
171embryonic retina morphogenesis in camera-type eye (GO:0060059)2.25071334

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse9.60160032
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.26111260
3RXR_22158963_ChIP-Seq_LIVER_Mouse6.49732598
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.66815957
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.20058781
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.87864834
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.17460825
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.09332514
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.90623296
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.60285942
11TP63_17297297_ChIP-ChIP_HaCaT_Human3.45126127
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.38213178
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.99129549
14ZNF217_24962896_ChIP-Seq_MCF-7_Human2.73338344
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.64606193
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.44388036
17CLOCK_20551151_ChIP-Seq_293T_Human2.43495503
18SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.33099638
19SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.33099638
20E2F7_22180533_ChIP-Seq_HELA_Human2.31630627
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.08721416
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.00274868
23KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.99467468
24AHR_22903824_ChIP-Seq_MCF-7_Human1.90566069
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.85545542
26GATA6_25053715_ChIP-Seq_YYC3_Human1.67654956
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.62978718
28ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.59460113
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.56716297
30ARNT_22903824_ChIP-Seq_MCF-7_Human1.48182105
31FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.48117450
32EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.47718827
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.45972352
34KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44920597
35TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.44590350
36ATF3_27146783_Chip-Seq_COLON_Human1.44237175
37FOXM1_26456572_ChIP-Seq_MCF-7_Human1.44138178
38ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43384801
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.42074337
40PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.40891837
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35943266
42CJUN_26792858_Chip-Seq_BT549_Human1.35342755
43TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32384589
44TCF4_18268006_ChIP-ChIP_LS174T_Human1.32184731
45AR_21909140_ChIP-Seq_LNCAP_Human1.29790579
46PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.28874232
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.27966999
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19625778
49CHD1_26751641_Chip-Seq_LNCaP_Human1.19331977
50RUNX1_27514584_Chip-Seq_MCF-7_Human1.19300389
51AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.18114249
52UBF1/2_26484160_Chip-Seq_HMECs_Human1.18025802
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17563006
54CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17127504
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16884171
56HTT_18923047_ChIP-ChIP_STHdh_Human1.16627737
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14100954
58TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13518613
59SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12765565
60ZNF263_19887448_ChIP-Seq_K562_Human1.11509296
61GATA4_25053715_ChIP-Seq_YYC3_Human1.11185356
62FOXA2_19822575_ChIP-Seq_HepG2_Human1.10522235
63RXR_22108803_ChIP-Seq_LS180_Human1.09823612
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08344239
65P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07220551
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.05514038
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05464242
68P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04749055
69PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04542399
70SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03990351
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03778674
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03341665
73PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.01791240
74HNF4A_19822575_ChIP-Seq_HepG2_Human0.99431487
75RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98715163
76KLF5_25053715_ChIP-Seq_YYC3_Human0.98498808
77TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97072826
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97070720
79SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93245031
80RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91974733
81BRD4_25478319_ChIP-Seq_HGPS_Human0.91610139
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88630941
83GATA1_22025678_ChIP-Seq_K562_Human0.88499487
84ELF5_23300383_ChIP-Seq_T47D_Human0.86038521
85EP300_21415370_ChIP-Seq_HL-1_Mouse0.85341827
86FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.84556632
87ESR1_21235772_ChIP-Seq_MCF-7_Human0.84319763
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83512836
89SOX17_20123909_ChIP-Seq_XEN_Mouse0.82602330
90MYC_18555785_ChIP-Seq_MESCs_Mouse0.81863049
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80498654
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.80255279
93NELFA_20434984_ChIP-Seq_ESCs_Mouse0.80190214
94NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.79600339
95NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79400044
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79400044
97ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79359327
98RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78536357
99FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.78191690
100GATA3_24758297_ChIP-Seq_MCF-7_Human0.77656431
101NANOG_18692474_ChIP-Seq_MEFs_Mouse0.77498523
102ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77228917
103PPAR_26484153_Chip-Seq_NCI-H1993_Human0.76887493
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.76679025
105SOX2_20726797_ChIP-Seq_SW620_Human0.76524848
106AR_20517297_ChIP-Seq_VCAP_Human0.75737708
107SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.75730403
108CEBPB_22108803_ChIP-Seq_LS180_Human0.75627353
109IRF1_19129219_ChIP-ChIP_H3396_Human0.74790857
110STAT3_1855785_ChIP-Seq_MESCs_Mouse0.72289667
111AUTS2_25519132_ChIP-Seq_293T-REX_Human0.71403280
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.71386606
113SOX2_18692474_ChIP-Seq_MEFs_Mouse0.71149310
114KAP1_22055183_ChIP-Seq_ESCs_Mouse0.68617682
115SOX9_24532713_ChIP-Seq_HFSC_Mouse0.67131443
116CSB_26484114_Chip-Seq_FIBROBLAST_Human0.66787942
117BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63758440
118ESR1_20079471_ChIP-ChIP_T-47D_Human0.61391673
119RACK7_27058665_Chip-Seq_MCF-7_Human0.59966424
120NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.59150541
121FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.57669559
122ERG_20517297_ChIP-Seq_VCAP_Human0.57360587
123CDX2_20551321_ChIP-Seq_CACO-2_Human0.57356750
124PIAS1_25552417_ChIP-Seq_VCAP_Human0.56315756
125HIF1A_21447827_ChIP-Seq_MCF-7_Human0.55969025
126SOX2_22085726_ChIP-Seq_NPCs_Mouse0.54754369
127OCT4_18692474_ChIP-Seq_MEFs_Mouse0.53535150
128CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.53309067
129SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.52991317
130Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.52271502
131EOMES_21245162_ChIP-Seq_HESCs_Human0.52240288
132FOXA1_25552417_ChIP-Seq_VCAP_Human0.51756279
133P53_21459846_ChIP-Seq_SAOS-2_Human0.51465157
134ERG_21242973_ChIP-ChIP_JURKAT_Human0.51347475
135BCAT_22108803_ChIP-Seq_LS180_Human0.50873147
136PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.50645948
137TP63_23658742_ChIP-Seq_EP156T_Human0.48959713
138FLI1_21867929_ChIP-Seq_CD8_Mouse0.48688398
139CBP_21632823_ChIP-Seq_H3396_Human0.48641731
140ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.47336399
141P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.47163927
142KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.47025052
143KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.47025052
144KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.47025052
145TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.44864596
146GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.44845395

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.38902254
2MP0005360_urolithiasis5.36948552
3MP0005365_abnormal_bile_salt4.46288612
4MP0003806_abnormal_nucleotide_metabolis4.29991289
5MP0005085_abnormal_gallbladder_physiolo3.76878905
6MP0005670_abnormal_white_adipose3.65844198
7MP0010329_abnormal_lipoprotein_level3.36016931
8MP0003941_abnormal_skin_development3.32338462
9MP0008875_abnormal_xenobiotic_pharmacok3.27084284
10MP0005409_darkened_coat_color3.12346171
11MP0005332_abnormal_amino_acid3.06907609
12MP0004185_abnormal_adipocyte_glucose2.86393843
13MP0009840_abnormal_foam_cell2.82027225
14MP0005666_abnormal_adipose_tissue2.72776291
15MP0009379_abnormal_foot_pigmentation2.67202025
16MP0003186_abnormal_redox_activity2.63733921
17MP0009780_abnormal_chondrocyte_physiolo2.59091640
18MP0003566_abnormal_cell_adhesion2.58566129
19MP0002796_impaired_skin_barrier2.46810055
20MP0003191_abnormal_cellular_cholesterol2.42737530
21MP0002254_reproductive_system_inflammat2.35830323
22MP0004264_abnormal_extraembryonic_tissu2.31243298
23MP0002118_abnormal_lipid_homeostasis2.29091722
24MP0004272_abnormal_basement_membrane2.27236855
25MP0003195_calcinosis2.24860139
26MP0003690_abnormal_glial_cell2.12452122
27MP0004019_abnormal_vitamin_homeostasis2.11544333
28MP0004130_abnormal_muscle_cell2.10029101
29MP0003011_delayed_dark_adaptation2.08638290
30MP0000762_abnormal_tongue_morphology1.92097208
31MP0010352_gastrointestinal_tract_polyps1.89684730
32MP0003252_abnormal_bile_duct1.88438389
33MP0000467_abnormal_esophagus_morphology1.84631813
34MP0009053_abnormal_anal_canal1.81586734
35MP0000609_abnormal_liver_physiology1.81178452
36MP0001666_abnormal_nutrient_absorption1.80757416
37MP0002971_abnormal_brown_adipose1.77730672
38MP0005375_adipose_tissue_phenotype1.76881984
39MP0004782_abnormal_surfactant_physiolog1.69178638
40MP0001661_extended_life_span1.67292021
41MP0001764_abnormal_homeostasis1.58936116
42MP0005584_abnormal_enzyme/coenzyme_acti1.57260187
43MP0005319_abnormal_enzyme/_coenzyme1.56929098
44MP0003329_amyloid_beta_deposits1.53518935
45MP0002877_abnormal_melanocyte_morpholog1.53335225
46MP0000627_abnormal_mammary_gland1.50245520
47MP0009643_abnormal_urine_homeostasis1.46660708
48MP0008057_abnormal_DNA_replication1.39841629
49MP0005076_abnormal_cell_differentiation1.39222265
50MP0003656_abnormal_erythrocyte_physiolo1.38040913
51MP0000566_synostosis1.36770324
52MP0005023_abnormal_wound_healing1.33846455
53MP0000604_amyloidosis1.27931130
54MP0000537_abnormal_urethra_morphology1.27287019
55MP0005501_abnormal_skin_physiology1.24540257
56MP0005647_abnormal_sex_gland1.23629541
57MP0001849_ear_inflammation1.22697614
58MP0005275_abnormal_skin_tensile1.22072635
59MP0005623_abnormal_meninges_morphology1.21795485
60MP0005083_abnormal_biliary_tract1.21150234
61MP0002876_abnormal_thyroid_physiology1.20598422
62MP0003890_abnormal_embryonic-extraembry1.19878406
63MP0009115_abnormal_fat_cell1.18976271
64MP0004043_abnormal_pH_regulation1.17243386
65MP0009384_cardiac_valve_regurgitation1.15538824
66MP0003705_abnormal_hypodermis_morpholog1.15436193
67MP0002009_preneoplasia1.13772725
68MP0005058_abnormal_lysosome_morphology1.12930384
69MP0003950_abnormal_plasma_membrane1.12743437
70MP0005334_abnormal_fat_pad1.12429371
71MP0008438_abnormal_cutaneous_collagen1.11373103
72MP0000462_abnormal_digestive_system1.07371770
73MP0005636_abnormal_mineral_homeostasis1.06081725
74MP0005451_abnormal_body_composition1.04599198
75MP0000647_abnormal_sebaceous_gland1.02509762
76MP0002060_abnormal_skin_morphology1.02113819
77MP0005408_hypopigmentation1.00291903
78MP0005535_abnormal_body_temperature0.99459153
79MP0004233_abnormal_muscle_weight0.98887253
80MP0000579_abnormal_nail_morphology0.98472815
81MP0000383_abnormal_hair_follicle0.96579004
82MP0010678_abnormal_skin_adnexa0.96005131
83MP0002234_abnormal_pharynx_morphology0.95250814
84MP0004381_abnormal_hair_follicle0.94481675
85MP0001216_abnormal_epidermal_layer0.88785400
86MP0000003_abnormal_adipose_tissue0.88502718
87MP0004885_abnormal_endolymph0.88454038
88MP0002697_abnormal_eye_size0.88064648
89MP0001881_abnormal_mammary_gland0.87943033
90MP0010030_abnormal_orbit_morphology0.87843610
91MP0002896_abnormal_bone_mineralization0.87737597
92MP0009763_increased_sensitivity_to0.87736484
93MP0003453_abnormal_keratinocyte_physiol0.87375139
94MP0003091_abnormal_cell_migration0.87315083
95MP0006138_congestive_heart_failure0.86537035
96MP0001756_abnormal_urination0.85304146
97MP0002970_abnormal_white_adipose0.83205859
98MP0003075_altered_response_to0.82448602
99MP0005376_homeostasis/metabolism_phenot0.81763186
100MP0009764_decreased_sensitivity_to0.80525223
101MP0000920_abnormal_myelination0.79201820
102MP0006036_abnormal_mitochondrial_physio0.78188841
103MP0010234_abnormal_vibrissa_follicle0.77965922
104MP0000598_abnormal_liver_morphology0.77558100
105MP0002098_abnormal_vibrissa_morphology0.76499710
106MP0003718_maternal_effect0.76452171
107MP0002089_abnormal_postnatal_growth/wei0.75945973
108MP0001348_abnormal_lacrimal_gland0.75389827
109MP0009672_abnormal_birth_weight0.73881844
110MP0009931_abnormal_skin_appearance0.73139381
111MP0000427_abnormal_hair_cycle0.73134496
112MP0004147_increased_porphyrin_level0.73086304
113MP0003724_increased_susceptibility_to0.72634138
114MP0003868_abnormal_feces_composition0.72416874
115MP0004957_abnormal_blastocyst_morpholog0.71875393
116MP0003936_abnormal_reproductive_system0.71718487
117MP0009765_abnormal_xenobiotic_induced0.71519005
118MP0003959_abnormal_lean_body0.69979479
119MP0010771_integument_phenotype0.68980785
120MP0003315_abnormal_perineum_morphology0.68354767
121MP0000367_abnormal_coat/_hair0.68149087
122MP0002086_abnormal_extraembryonic_tissu0.68117931
123MP0000377_abnormal_hair_follicle0.67920622
124MP0005164_abnormal_response_to0.67377159
125MP0001340_abnormal_eyelid_morphology0.67268238
126MP0003755_abnormal_palate_morphology0.66999533
127MP0005257_abnormal_intraocular_pressure0.66010443
128MP0002078_abnormal_glucose_homeostasis0.65782899
129MP0002136_abnormal_kidney_physiology0.65724518
130MP0005595_abnormal_vascular_smooth0.64941392
131MP0005380_embryogenesis_phenotype0.63330136
132MP0001672_abnormal_embryogenesis/_devel0.63330136
133MP0002909_abnormal_adrenal_gland0.62837601
134MP0005395_other_phenotype0.62763291
135MP0009642_abnormal_blood_homeostasis0.62590086
136MP0003984_embryonic_growth_retardation0.61170203
137MP0001730_embryonic_growth_arrest0.61019211
138MP0002088_abnormal_embryonic_growth/wei0.60956319
139MP0001853_heart_inflammation0.60277390
140MP0005266_abnormal_metabolism0.60077075
141MP0008469_abnormal_protein_level0.59669755
142MP0003136_yellow_coat_color0.59306389
143MP0002295_abnormal_pulmonary_circulatio0.58566721
144MP0005197_abnormal_uvea_morphology0.58198955
145MP0002084_abnormal_developmental_patter0.58100277
146MP0003937_abnormal_limbs/digits/tail_de0.57820074
147MP0005165_increased_susceptibility_to0.55020701
148MP0005448_abnormal_energy_balance0.54919532
149MP0001765_abnormal_ion_homeostasis0.54318019
150MP0009697_abnormal_copulation0.53544327
151MP0001243_abnormal_dermal_layer0.51824924
152MP0003638_abnormal_response/metabolism_0.49458078
153MP0000343_altered_response_to0.46807363

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)5.64458653
2Abnormality of glycine metabolism (HP:0010895)5.37298182
3Abnormality of serine family amino acid metabolism (HP:0010894)5.37298182
4Xanthomatosis (HP:0000991)5.33619646
5Hyperlipoproteinemia (HP:0010980)5.28751720
6Right ventricular cardiomyopathy (HP:0011663)5.06247111
7Intrahepatic cholestasis (HP:0001406)4.98008911
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.80146075
9Milia (HP:0001056)4.66999524
10Hyperglycinemia (HP:0002154)4.65099577
11Hyperammonemia (HP:0001987)4.61683422
12Deep venous thrombosis (HP:0002625)4.41543424
13Complement deficiency (HP:0004431)4.29636392
14Ketosis (HP:0001946)4.27907309
15Fragile nails (HP:0001808)4.22523365
16Hypoalphalipoproteinemia (HP:0003233)4.19933802
17Atrophic scars (HP:0001075)4.00154899
18Prolonged partial thromboplastin time (HP:0003645)3.95610514
19Hypolipoproteinemia (HP:0010981)3.88961805
20Plantar hyperkeratosis (HP:0007556)3.86853743
21Hypoglycemic coma (HP:0001325)3.85744078
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.83498919
23Abnormality of monocarboxylic acid metabolism (HP:0010996)3.82614035
24Hypobetalipoproteinemia (HP:0003563)3.82577448
25Epidermoid cyst (HP:0200040)3.69684523
26Ketoacidosis (HP:0001993)3.66446924
27Abnormality of fatty-acid metabolism (HP:0004359)3.49990584
28Delayed CNS myelination (HP:0002188)3.47284039
29Abnormality of aspartate family amino acid metabolism (HP:0010899)3.29892913
30Dicarboxylic aciduria (HP:0003215)3.28731248
31Abnormality of dicarboxylic acid metabolism (HP:0010995)3.28731248
32Abnormality of sulfur amino acid metabolism (HP:0004339)3.20407400
33Hypertriglyceridemia (HP:0002155)3.19112930
34Abnormality of glutamine family amino acid metabolism (HP:0010902)3.18957819
35Neurofibrillary tangles (HP:0002185)3.14526363
36Abnormality of methionine metabolism (HP:0010901)3.14166025
37Pili torti (HP:0003777)3.13969812
38Abnormality of the axillary hair (HP:0100134)3.10978898
39Abnormality of secondary sexual hair (HP:0009888)3.10978898
40Alopecia of scalp (HP:0002293)3.10324277
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.08184484
42Abnormality of complement system (HP:0005339)3.05759494
43Hypoplasia of dental enamel (HP:0006297)2.97294958
44Flat acetabular roof (HP:0003180)2.90618583
45Lethargy (HP:0001254)2.89758381
46Acanthosis nigricans (HP:0000956)2.89483636
47Hypotrichosis (HP:0001006)2.88894677
48Pterygium (HP:0001059)2.88091172
49Abnormality of serum amino acid levels (HP:0003112)2.82970278
50Nail dystrophy (HP:0008404)2.81286823
51Hypercholesterolemia (HP:0003124)2.80879320
52Ridged nail (HP:0001807)2.78368760
53Fat malabsorption (HP:0002630)2.77200685
54Amyloidosis (HP:0011034)2.73844372
55Abnormal hair laboratory examination (HP:0003328)2.63754817
56Palmoplantar hyperkeratosis (HP:0000972)2.59778895
57Abnormality of the common coagulation pathway (HP:0010990)2.58699335
58Vascular calcification (HP:0004934)2.57785214
59Parakeratosis (HP:0001036)2.57661504
60Metabolic acidosis (HP:0001942)2.56117043
61Myocardial infarction (HP:0001658)2.55623714
62Abnormality of the gastric mucosa (HP:0004295)2.55388692
63Methylmalonic aciduria (HP:0012120)2.51664025
64Palmar hyperkeratosis (HP:0010765)2.45238025
65Natal tooth (HP:0000695)2.45066800
66Pancreatitis (HP:0001733)2.44421235
67Sparse eyelashes (HP:0000653)2.43276922
68Mitral stenosis (HP:0001718)2.41064389
69Steatorrhea (HP:0002570)2.40817496
70Vomiting (HP:0002013)2.40770870
71Advanced eruption of teeth (HP:0006288)2.40753694
72Thick nail (HP:0001805)2.40275582
73Nausea (HP:0002018)2.40147442
74Joint hemorrhage (HP:0005261)2.38792996
75Woolly hair (HP:0002224)2.37520797
76Selective tooth agenesis (HP:0001592)2.36793974
77Brushfield spots (HP:0001088)2.36732841
78Abnormality of purine metabolism (HP:0004352)2.34258213
79Hydroxyprolinuria (HP:0003080)2.33591842
80Abnormality of proline metabolism (HP:0010907)2.33591842
81Cerebral edema (HP:0002181)2.33374735
82Fragile skin (HP:0001030)2.31681338
83Generalized aminoaciduria (HP:0002909)2.31575122
84Confusion (HP:0001289)2.28061915
85Cardiovascular calcification (HP:0011915)2.25904956
86Arterial tortuosity (HP:0005116)2.25441414
87Abnormality of the intrinsic pathway (HP:0010989)2.24649815
88Onycholysis (HP:0001806)2.24416759
89Cerebral inclusion bodies (HP:0100314)2.23541419
90Abnormality of carpal bone ossification (HP:0006257)2.23100583
91Short nail (HP:0001799)2.21287087
92Ankyloglossia (HP:0010296)2.20108237
93Amelogenesis imperfecta (HP:0000705)2.19152151
94Abnormality of nucleobase metabolism (HP:0010932)2.15549332
95Microglossia (HP:0000171)2.15290630
96Spastic paraparesis (HP:0002313)2.13323011
97Proximal tubulopathy (HP:0000114)2.12947371
98Methylmalonic acidemia (HP:0002912)2.11315232
99Papillary thyroid carcinoma (HP:0002895)2.11274060
100Overlapping toe (HP:0001845)2.10866101
101Irritability (HP:0000737)2.09593133
102Premature rupture of membranes (HP:0001788)2.08543867
103Osteolytic defects of the phalanges of the hand (HP:0009771)2.08193007
104Osteolytic defects of the hand bones (HP:0009699)2.08193007
105Curly hair (HP:0002212)2.05902149
106Congenital ichthyosiform erythroderma (HP:0007431)2.04491017
107Asymmetry of the thorax (HP:0001555)2.02203487
108Aplasia cutis congenita (HP:0001057)2.01378907
109Aplasia involving bones of the upper limbs (HP:0009823)2.00659245
110Aplasia of the phalanges of the hand (HP:0009802)2.00659245
111Aplasia involving bones of the extremities (HP:0009825)2.00659245
112Increased muscle lipid content (HP:0009058)2.00413606
113Opisthotonus (HP:0002179)1.99518169
114Missing ribs (HP:0000921)1.98330609
115Vascular tortuosity (HP:0004948)1.98180347
116Hyperbilirubinemia (HP:0002904)1.97914021
117Hypoglycemic seizures (HP:0002173)1.95618266
118Pseudobulbar signs (HP:0002200)1.94811629
119Synostosis involving the elbow (HP:0003938)1.92926460
120Humeroradial synostosis (HP:0003041)1.92926460
121Respiratory distress (HP:0002098)1.92084930
122Absent eyelashes (HP:0000561)1.91823747
123Conjugated hyperbilirubinemia (HP:0002908)1.91324385
124Abnormality of the nasal septum (HP:0000419)1.91159878
125Abnormality of oral frenula (HP:0000190)1.90878254
126Hypophosphatemic rickets (HP:0004912)1.90797239
127Abnormality of nail color (HP:0100643)1.89885097
128Abnormal hemoglobin (HP:0011902)1.89612125
129Malnutrition (HP:0004395)1.88140002
130Abnormality of urine glucose concentration (HP:0011016)1.86059512
131Glycosuria (HP:0003076)1.86059512
132Back pain (HP:0003418)1.83459596
133Cheilitis (HP:0100825)1.83399787
134Coronal craniosynostosis (HP:0004440)1.83045255
135Abnormal ossification of hand bones (HP:0005921)1.82263879
136Late onset (HP:0003584)1.81806549
137Abnormal tarsal ossification (HP:0008369)1.80369223
138Renal tubular acidosis (HP:0001947)1.79865274
139Rickets (HP:0002748)1.79573058
140Skin nodule (HP:0200036)1.79464602
141Coarse hair (HP:0002208)1.79070590
142Septate vagina (HP:0001153)1.78148551
143Focal segmental glomerulosclerosis (HP:0000097)1.78146261
144Abnormality of pyrimidine metabolism (HP:0004353)1.78131570
145Sensorimotor neuropathy (HP:0007141)1.77705601
146Spinal cord compression (HP:0002176)1.76955808
147Protrusio acetabuli (HP:0003179)1.74150805
148Delayed myelination (HP:0012448)1.73555849
149Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.73088279
150Gout (HP:0001997)1.72585104
151Lip pit (HP:0100267)1.72441297
152Abnormality of transition element cation homeostasis (HP:0011030)1.72342694
153Prenatal maternal abnormality (HP:0002686)1.72091279
154Potter facies (HP:0002009)1.71968521
155Facial shape deformation (HP:0011334)1.71968521
156Systemic lupus erythematosus (HP:0002725)1.71931879
157Coxa vara (HP:0002812)1.70318910
158Neonatal death (HP:0003811)1.69978265
159Abnormal blistering of the skin (HP:0008066)1.69879745
160Abnormal foot bone ossification (HP:0010675)1.68830528
161Blepharitis (HP:0000498)1.67537112
162Abnormal hand bone ossification (HP:0010660)1.64365255
16311 pairs of ribs (HP:0000878)1.64113108
164Hyperparathyroidism (HP:0000843)1.63172047
165Micronodular cirrhosis (HP:0001413)1.62149550
166Hypoplastic labia majora (HP:0000059)1.62012660
167Facial hemangioma (HP:0000329)1.61936328
168Abnormality of the distal phalanges of the toes (HP:0010182)1.60950940
169Buphthalmos (HP:0000557)1.59785185
170Termporal pattern (HP:0011008)1.57432647
171Insidious onset (HP:0003587)1.57432647
172Cervical subluxation (HP:0003308)1.56134982
173Ulnar bowing (HP:0003031)1.55723080

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK9.45674494
2SIK13.64585909
3ERN13.19582541
4SCYL23.19125734
5MAP3K92.85135736
6STK162.72522799
7CAMK1D2.64659664
8STK392.43160029
9TRIB32.24404211
10MET2.21729110
11PBK2.06883801
12MAP3K122.02928319
13MST1R2.00970108
14OXSR11.93015896
15FGFR21.89922826
16FGFR41.85048887
17RPS6KB21.82509428
18LATS11.76372137
19EEF2K1.66078065
20EIF2AK11.64068040
21CAMK1G1.60120492
22ICK1.58885728
23SMG11.58884918
24MAP3K21.56645520
25PDGFRA1.56263293
26CDK121.54321531
27PDK41.48255525
28PDK31.48255525
29EPHB11.46908065
30WNK41.45762022
31PAK41.42528533
32MST41.39261184
33LMTK21.38718079
34ARAF1.38292171
35EPHA41.32797758
36PRKAA21.32743939
37NTRK11.28404029
38EIF2AK31.18227523
39ABL21.17723823
40PIK3CG1.16069915
41PKN21.15910658
42ERBB41.10751611
43NEK11.08775258
44NEK61.06476560
45TAOK31.06248363
46PIK3CA1.06096471
47EPHA21.01984274
48TSSK60.99035787
49MAPK110.94193806
50TAF10.92927708
51IRAK30.92780947
52PNCK0.90715653
53PHKG20.90072144
54PHKG10.90072144
55STK380.89806509
56FER0.89174456
57MUSK0.86671286
58MELK0.86074196
59MAPK150.84833991
60MTOR0.84335080
61LRRK20.82361522
62TTK0.81488454
63PAK20.81147832
64BRSK20.80530058
65FLT30.80439156
66TRPM70.78246002
67PDK20.78235947
68IRAK10.78165610
69PDGFRB0.74308113
70PRKCI0.73839757
71CAMK2G0.73473502
72BCR0.73092746
73INSRR0.72389566
74MYLK0.70575174
75KSR20.70470015
76NEK90.70363272
77RIPK10.70003187
78PTK60.69660100
79TESK10.69489986
80STK100.69274028
81PINK10.69114886
82STK240.67243754
83CDK70.66086365
84TESK20.64794781
85IRAK20.64676907
86MAPKAPK30.62669785
87AKT30.62617934
88YES10.62375957
89MAP2K10.61358425
90TGFBR10.59516019
91BRAF0.59476309
92PRKACG0.59246845
93DDR20.57299215
94TNK20.57004958
95MAPK40.56184368
96PDPK10.55967043
97TYK20.55222572
98EIF2AK20.54251576
99STK38L0.54125670
100MAPKAPK50.52821965
101RPS6KB10.52777961
102CDC70.52336333
103RPS6KA20.52199976
104CSNK1G10.51957281
105MAP2K20.51545457
106PRKD30.51228026
107SGK30.50953998
108MAPK120.46717537
109TRIM280.46619268
110STK30.46431116
111LATS20.46389523
112IGF1R0.44860726
113WNK30.44026589
114EPHB20.43849424
115DAPK30.43790877
116AKT20.43489426
117AURKB0.43123943
118NTRK20.42837198
119DYRK20.42799489
120CAMK2B0.42251668
121JAK20.41997181
122MAP3K30.41961661
123PRKCQ0.41215651
124CDK190.41209561
125FGFR10.40337455
126WEE10.40179898
127FGR0.39756261
128MAP3K80.38620376
129MAP3K60.38197400
130RET0.37974896
131CDK60.37967222
132ILK0.37060039
133PRKCZ0.36651588
134GSK3A0.36450069
135PRKAA10.35294035
136KDR0.34726916
137PIM20.34364263
138CDK90.33904930
139CSNK1E0.33789600
140FGFR30.33707478
141PTK20.33534267
142SIK30.32921851
143PRKD10.31702161
144NME20.31692121
145DAPK20.30419458
146CAMK2D0.29347447
147WNK10.29115481
148TYRO30.29111829
149ADRBK10.27583655
150LIMK10.27400659
151CSNK1A1L0.26974092
152PRKG10.26792992
153BMX0.26143871
154SGK4940.25703854
155SGK2230.25703854
156PRKCA0.25145232
157CSF1R0.25102166
158CSNK1G30.24714470
159CSK0.24417169

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.30752601
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.10341881
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.08503159
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.90974455
5Propanoate metabolism_Homo sapiens_hsa006402.89866603
6Fatty acid degradation_Homo sapiens_hsa000712.89721469
7Fatty acid metabolism_Homo sapiens_hsa012122.76673241
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.67131649
9PPAR signaling pathway_Homo sapiens_hsa033202.62212744
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49138954
11Fatty acid biosynthesis_Homo sapiens_hsa000612.47856317
12Fatty acid elongation_Homo sapiens_hsa000622.41404688
13Peroxisome_Homo sapiens_hsa041462.32598002
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.22432576
15Butanoate metabolism_Homo sapiens_hsa006502.04166079
16Arginine biosynthesis_Homo sapiens_hsa002202.02377740
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.97250894
18Tryptophan metabolism_Homo sapiens_hsa003801.96595776
19Steroid biosynthesis_Homo sapiens_hsa001001.83549660
20Complement and coagulation cascades_Homo sapiens_hsa046101.81434241
21ECM-receptor interaction_Homo sapiens_hsa045121.79620357
22beta-Alanine metabolism_Homo sapiens_hsa004101.77199420
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.76756166
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76741718
25Chemical carcinogenesis_Homo sapiens_hsa052041.70433739
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.70347079
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.68355892
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64172658
29Sulfur metabolism_Homo sapiens_hsa009201.63689194
30Histidine metabolism_Homo sapiens_hsa003401.62955681
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58568872
32Pyruvate metabolism_Homo sapiens_hsa006201.57116940
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51800813
34Caffeine metabolism_Homo sapiens_hsa002321.50357250
35Glycerolipid metabolism_Homo sapiens_hsa005611.46153270
36Thyroid cancer_Homo sapiens_hsa052161.42532782
37Retinol metabolism_Homo sapiens_hsa008301.36960832
38Carbon metabolism_Homo sapiens_hsa012001.34158690
39Folate biosynthesis_Homo sapiens_hsa007901.31914359
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.29526607
41Tyrosine metabolism_Homo sapiens_hsa003501.28631321
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.27961159
43Phenylalanine metabolism_Homo sapiens_hsa003601.25017579
44Fat digestion and absorption_Homo sapiens_hsa049751.22660129
45Glutathione metabolism_Homo sapiens_hsa004801.21287621
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19577319
47Bile secretion_Homo sapiens_hsa049761.16463274
48Small cell lung cancer_Homo sapiens_hsa052221.14808862
49Staphylococcus aureus infection_Homo sapiens_hsa051501.14005622
50Biosynthesis of amino acids_Homo sapiens_hsa012301.12384860
51Drug metabolism - other enzymes_Homo sapiens_hsa009831.11996892
52Vitamin digestion and absorption_Homo sapiens_hsa049771.09004925
53Vitamin B6 metabolism_Homo sapiens_hsa007501.08928724
54Adherens junction_Homo sapiens_hsa045201.08221733
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.07225768
56Hippo signaling pathway_Homo sapiens_hsa043901.06504595
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05957866
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99199686
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99053156
60Selenocompound metabolism_Homo sapiens_hsa004500.96553532
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95440228
62Pentose phosphate pathway_Homo sapiens_hsa000300.93821739
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93501577
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91667478
65Proteoglycans in cancer_Homo sapiens_hsa052050.91420125
66Focal adhesion_Homo sapiens_hsa045100.90646014
67Arginine and proline metabolism_Homo sapiens_hsa003300.88860826
68Sulfur relay system_Homo sapiens_hsa041220.88100544
69Starch and sucrose metabolism_Homo sapiens_hsa005000.86475407
70N-Glycan biosynthesis_Homo sapiens_hsa005100.85042037
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82023169
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81623929
73ABC transporters_Homo sapiens_hsa020100.81605024
74Linoleic acid metabolism_Homo sapiens_hsa005910.78948244
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.73322971
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72731653
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71132837
78TGF-beta signaling pathway_Homo sapiens_hsa043500.70326678
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65774516
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64117095
81Metabolic pathways_Homo sapiens_hsa011000.63109277
82Endometrial cancer_Homo sapiens_hsa052130.62685325
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62070478
84Tight junction_Homo sapiens_hsa045300.61506287
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.61498171
86Renal cell carcinoma_Homo sapiens_hsa052110.57887373
87Fructose and mannose metabolism_Homo sapiens_hsa000510.56445368
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.55350370
89ErbB signaling pathway_Homo sapiens_hsa040120.52833772
90Ether lipid metabolism_Homo sapiens_hsa005650.52758338
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49663844
92Prostate cancer_Homo sapiens_hsa052150.49242348
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48665010
94MicroRNAs in cancer_Homo sapiens_hsa052060.47317283
95Insulin signaling pathway_Homo sapiens_hsa049100.46575640
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46239041
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45414282
98Lysine degradation_Homo sapiens_hsa003100.45349592
99Amoebiasis_Homo sapiens_hsa051460.44463962
100Inositol phosphate metabolism_Homo sapiens_hsa005620.44450916
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44435047
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43310962
103Arachidonic acid metabolism_Homo sapiens_hsa005900.43280920
104Vibrio cholerae infection_Homo sapiens_hsa051100.42936201
105Estrogen signaling pathway_Homo sapiens_hsa049150.41336279
106One carbon pool by folate_Homo sapiens_hsa006700.38208006
107Renin-angiotensin system_Homo sapiens_hsa046140.33419109
108AMPK signaling pathway_Homo sapiens_hsa041520.33053882
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30533261
110Mineral absorption_Homo sapiens_hsa049780.22984529
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.22799508
112Insulin resistance_Homo sapiens_hsa049310.11375161
113Sphingolipid metabolism_Homo sapiens_hsa006000.10755594
114Lysosome_Homo sapiens_hsa041420.10554648
115Galactose metabolism_Homo sapiens_hsa000520.10036474
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.10000333
117Oxidative phosphorylation_Homo sapiens_hsa001900.09794824
118Thyroid hormone synthesis_Homo sapiens_hsa049180.05587190
119Protein export_Homo sapiens_hsa030600.04920555
120Protein digestion and absorption_Homo sapiens_hsa049740.04834309
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.02081036
122Glucagon signaling pathway_Homo sapiens_hsa049220.01974712
123Parkinsons disease_Homo sapiens_hsa05012-0.0700454
124Basal cell carcinoma_Homo sapiens_hsa05217-0.0697840
125Alzheimers disease_Homo sapiens_hsa05010-0.0624104
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0480669
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0289681
128Prion diseases_Homo sapiens_hsa05020-0.0255631
129Bladder cancer_Homo sapiens_hsa05219-0.0174168
130Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0110370

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »