HACD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)4.64491742
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.64491742
3L-phenylalanine metabolic process (GO:0006558)4.26502780
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.26502780
5alpha-linolenic acid metabolic process (GO:0036109)4.06817741
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.86322534
7aromatic amino acid family catabolic process (GO:0009074)3.81503899
8bile acid biosynthetic process (GO:0006699)3.65499370
9neurotransmitter-gated ion channel clustering (GO:0072578)3.63928866
10high-density lipoprotein particle remodeling (GO:0034375)3.54452490
11glutamate secretion (GO:0014047)3.50653110
12cellular ketone body metabolic process (GO:0046950)3.50488883
13regulation of short-term neuronal synaptic plasticity (GO:0048172)3.44921991
14reverse cholesterol transport (GO:0043691)3.44673200
15chromatin remodeling at centromere (GO:0031055)3.37594752
16synaptic vesicle exocytosis (GO:0016079)3.37392709
17glutamate metabolic process (GO:0006536)3.36032249
18gamma-aminobutyric acid transport (GO:0015812)3.35039369
19pyrimidine nucleobase catabolic process (GO:0006208)3.30341153
20CENP-A containing nucleosome assembly (GO:0034080)3.27745778
21establishment of integrated proviral latency (GO:0075713)3.25031219
22neuron cell-cell adhesion (GO:0007158)3.24733811
23dicarboxylic acid biosynthetic process (GO:0043650)3.19038249
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.18267497
25indole-containing compound catabolic process (GO:0042436)3.15897749
26indolalkylamine catabolic process (GO:0046218)3.15897749
27tryptophan catabolic process (GO:0006569)3.15897749
28glyoxylate metabolic process (GO:0046487)3.15114097
29kynurenine metabolic process (GO:0070189)3.13770440
30neurotransmitter secretion (GO:0007269)3.13570276
31coenzyme catabolic process (GO:0009109)3.13152243
32vocalization behavior (GO:0071625)3.12909663
33regulation of synaptic vesicle exocytosis (GO:2000300)3.12511424
34plasma lipoprotein particle remodeling (GO:0034369)3.09835363
35protein-lipid complex remodeling (GO:0034368)3.09835363
36macromolecular complex remodeling (GO:0034367)3.09835363
37regulation of cholesterol esterification (GO:0010872)3.09462529
38tryptophan metabolic process (GO:0006568)3.08622955
39alanine transport (GO:0032328)3.07714981
40DNA replication checkpoint (GO:0000076)3.06406997
41low-density lipoprotein particle remodeling (GO:0034374)3.05044094
42bile acid metabolic process (GO:0008206)3.03374936
43ketone body metabolic process (GO:1902224)3.03341499
44synaptic vesicle maturation (GO:0016188)3.01685776
45nuclear pore complex assembly (GO:0051292)3.00785139
46locomotory exploration behavior (GO:0035641)2.99221070
47nuclear pore organization (GO:0006999)2.96916159
48protein localization to kinetochore (GO:0034501)2.96658915
49tyrosine metabolic process (GO:0006570)2.96272832
50cysteine metabolic process (GO:0006534)2.94996118
51fatty acid elongation (GO:0030497)2.94854359
52negative regulation of fibrinolysis (GO:0051918)2.92803673
53very long-chain fatty acid metabolic process (GO:0000038)2.91274055
54sulfur amino acid catabolic process (GO:0000098)2.90576161
55cellular potassium ion homeostasis (GO:0030007)2.90504655
56regulation of protein activation cascade (GO:2000257)2.89727799
57cellular modified amino acid catabolic process (GO:0042219)2.88023984
58mitotic sister chromatid cohesion (GO:0007064)2.87285274
59regulation of fibrinolysis (GO:0051917)2.86974321
60positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.86380388
61protein localization to synapse (GO:0035418)2.84275723
62urea cycle (GO:0000050)2.84162467
63urea metabolic process (GO:0019627)2.84162467
64L-serine metabolic process (GO:0006563)2.82948936
65regulation of synaptic vesicle transport (GO:1902803)2.81294647
66aromatic amino acid family metabolic process (GO:0009072)2.80913763
67alpha-amino acid catabolic process (GO:1901606)2.80009179
68paraxial mesoderm development (GO:0048339)2.78796253
69cholesterol efflux (GO:0033344)2.78762385
70histone exchange (GO:0043486)2.78389971
71regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.78130316
72dicarboxylic acid catabolic process (GO:0043649)2.78100556
73DNA strand elongation involved in DNA replication (GO:0006271)2.74986319
74negative regulation of protein activation cascade (GO:2000258)2.73173768
75regulation of glutamate receptor signaling pathway (GO:1900449)2.73170980
76DNA replication-independent nucleosome organization (GO:0034724)2.73113791
77DNA replication-independent nucleosome assembly (GO:0006336)2.73113791
78regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.71633558
79regulation of centriole replication (GO:0046599)2.71369593
80sister chromatid segregation (GO:0000819)2.70184788
81nucleobase catabolic process (GO:0046113)2.70119331
82lysine metabolic process (GO:0006553)2.69457634
83lysine catabolic process (GO:0006554)2.69457634
84mitotic metaphase plate congression (GO:0007080)2.69301008
85mitotic sister chromatid segregation (GO:0000070)2.68334276
86regulation of complement activation (GO:0030449)2.67320608
87DNA damage response, detection of DNA damage (GO:0042769)2.67314583
88protein carboxylation (GO:0018214)2.65829733
89peptidyl-glutamic acid carboxylation (GO:0017187)2.65829733
90layer formation in cerebral cortex (GO:0021819)2.64720305
91G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.64370145
92cellular amino acid catabolic process (GO:0009063)2.64276483
93DNA strand elongation (GO:0022616)2.63409681
94double-strand break repair via nonhomologous end joining (GO:0006303)2.63263304
95non-recombinational repair (GO:0000726)2.63263304
96proline transport (GO:0015824)2.63225989
97negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.61790584
98DNA unwinding involved in DNA replication (GO:0006268)2.61206716
99complement activation, alternative pathway (GO:0006957)2.59917373
100neurotransmitter transport (GO:0006836)2.59681653
101nitrogen cycle metabolic process (GO:0071941)2.58282963
102linoleic acid metabolic process (GO:0043651)2.58128333
103DNA double-strand break processing (GO:0000729)2.57694573
104DNA replication-dependent nucleosome organization (GO:0034723)2.57649359
105DNA replication-dependent nucleosome assembly (GO:0006335)2.57649359
106phospholipid efflux (GO:0033700)2.57562633
107metaphase plate congression (GO:0051310)2.57164426
108positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.56759624
109glutamate receptor signaling pathway (GO:0007215)2.56736296
110long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.56373563
111cholesterol catabolic process (GO:0006707)2.56042760
112sterol catabolic process (GO:0016127)2.56042760
113negative regulation of cholesterol transport (GO:0032375)2.55390555
114negative regulation of sterol transport (GO:0032372)2.55390555
115regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.55285929
116presynaptic membrane assembly (GO:0097105)2.55217923
117fatty-acyl-CoA biosynthetic process (GO:0046949)2.54907521
118regulation of cholesterol biosynthetic process (GO:0045540)2.53995632
119mating behavior (GO:0007617)2.51211895
120regulation of triglyceride catabolic process (GO:0010896)2.50643184
121very-low-density lipoprotein particle assembly (GO:0034379)2.50551376
122homocysteine metabolic process (GO:0050667)2.50250802
123synaptic vesicle docking involved in exocytosis (GO:0016081)2.50233562
124regulation of neurotransmitter levels (GO:0001505)2.49927334
125aspartate family amino acid catabolic process (GO:0009068)2.48872441
126indolalkylamine metabolic process (GO:0006586)2.48433311
127sodium ion export (GO:0071436)2.48310071
128acylglycerol homeostasis (GO:0055090)2.48219025
129triglyceride homeostasis (GO:0070328)2.48219025
130somatic hypermutation of immunoglobulin genes (GO:0016446)2.47606099
131somatic diversification of immune receptors via somatic mutation (GO:0002566)2.47606099
132spindle checkpoint (GO:0031577)2.47337258
133telomere maintenance via semi-conservative replication (GO:0032201)2.46495220
134protein localization to chromosome, centromeric region (GO:0071459)2.46181048
135DNA ligation (GO:0006266)2.46072748
136negative regulation of DNA recombination (GO:0045910)2.42097303
137regulation of DNA endoreduplication (GO:0032875)2.40146681
138cullin deneddylation (GO:0010388)2.35897670
139mitotic spindle checkpoint (GO:0071174)2.35575574
140regulation of helicase activity (GO:0051095)2.33711155
141purine nucleobase biosynthetic process (GO:0009113)2.33344738
142DNA strand renaturation (GO:0000733)2.33027263
143negative regulation of chromosome segregation (GO:0051985)2.31430852
144kinetochore organization (GO:0051383)2.30975007
145negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.29977845
146negative regulation of mitotic sister chromatid segregation (GO:0033048)2.29977845
147negative regulation of mitotic sister chromatid separation (GO:2000816)2.29977845
148negative regulation of sister chromatid segregation (GO:0033046)2.29977845
149negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.29977845
150presynaptic membrane organization (GO:0097090)2.28887160
151histone H2A acetylation (GO:0043968)2.27010127
152ATP-dependent chromatin remodeling (GO:0043044)2.26229983
153resolution of meiotic recombination intermediates (GO:0000712)2.26061287
154regulation of mitochondrial translation (GO:0070129)2.25483941
155establishment of viral latency (GO:0019043)2.25175520
156negative regulation of DNA-dependent DNA replication (GO:2000104)2.22962079
157nucleotide-excision repair, DNA gap filling (GO:0006297)2.21928547
158regulation of chromosome segregation (GO:0051983)2.20646375
159intraciliary transport (GO:0042073)2.18573765
160mitotic spindle organization (GO:0007052)2.18338355
161mitotic spindle assembly checkpoint (GO:0007094)2.17556233
162spindle assembly checkpoint (GO:0071173)2.17058420
163regulation of mitotic metaphase/anaphase transition (GO:0030071)2.16920724
164regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.16920724
165pre-miRNA processing (GO:0031054)2.15415340
166pore complex assembly (GO:0046931)2.15196585
167dorsal/ventral axis specification (GO:0009950)2.14783353
168mitotic recombination (GO:0006312)2.14516639
169nucleobase biosynthetic process (GO:0046112)2.13967237
170replication fork processing (GO:0031297)2.13904755
171nonmotile primary cilium assembly (GO:0035058)2.13103988
172regulation of sister chromatid segregation (GO:0033045)2.12835986
173regulation of mitotic sister chromatid separation (GO:0010965)2.12835986
174regulation of mitotic sister chromatid segregation (GO:0033047)2.12835986
175proteasome assembly (GO:0043248)2.11246792
176regulation of centrosome cycle (GO:0046605)2.10252682
177kinetochore assembly (GO:0051382)2.09766057
178protein deneddylation (GO:0000338)2.09622833
179protein K6-linked ubiquitination (GO:0085020)2.08806981
180establishment of protein localization to mitochondrial membrane (GO:0090151)2.08173204
181cholesterol biosynthetic process (GO:0006695)2.07592383
182DNA replication initiation (GO:0006270)2.06446493
183telomere maintenance via recombination (GO:0000722)2.06103539
184regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.05469016
185regulation of mitotic spindle checkpoint (GO:1903504)2.05469016
186postreplication repair (GO:0006301)2.03349266
187mitotic nuclear envelope disassembly (GO:0007077)2.01801983
188IMP biosynthetic process (GO:0006188)1.99736238
189serine family amino acid biosynthetic process (GO:0009070)1.99429455
190regulation of centrosome duplication (GO:0010824)1.98920231
191establishment of chromosome localization (GO:0051303)1.97906875
192heterochromatin organization (GO:0070828)1.97479261
193regulation of sister chromatid cohesion (GO:0007063)1.97292303
194negative regulation of mitosis (GO:0045839)1.95828742
195mitotic chromosome condensation (GO:0007076)1.94705274
196microtubule depolymerization (GO:0007019)1.93362296
197protein localization to chromosome (GO:0034502)1.93296946
198glutamine metabolic process (GO:0006541)1.93144553

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.43353914
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.15690467
3EZH2_22144423_ChIP-Seq_EOC_Human3.57929141
4GBX2_23144817_ChIP-Seq_PC3_Human3.27714562
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.96752765
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.88809957
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.83947808
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.73728928
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.69970838
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.62475049
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60259936
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47341474
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.36271212
14AR_21909140_ChIP-Seq_LNCAP_Human2.30754095
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.29226912
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28454910
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.27312947
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.24858313
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.23645311
20REST_21632747_ChIP-Seq_MESCs_Mouse2.23203810
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.17245389
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.16026363
23PPARA_22158963_ChIP-Seq_LIVER_Mouse2.15199603
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14968075
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14935924
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14018084
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.12240684
28RNF2_18974828_ChIP-Seq_MESCs_Mouse2.10739717
29EZH2_18974828_ChIP-Seq_MESCs_Mouse2.10739717
30GABP_17652178_ChIP-ChIP_JURKAT_Human2.09901658
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07970249
32EED_16625203_ChIP-ChIP_MESCs_Mouse2.07405231
33TAF15_26573619_Chip-Seq_HEK293_Human2.06736532
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04278233
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03420568
36AR_21572438_ChIP-Seq_LNCaP_Human1.98945387
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.94402593
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.93108367
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.91792655
40FUS_26573619_Chip-Seq_HEK293_Human1.91601236
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.88764777
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87450880
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.87380534
44EWS_26573619_Chip-Seq_HEK293_Human1.84731131
45ELK1_19687146_ChIP-ChIP_HELA_Human1.83718506
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83508893
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81901071
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.79386093
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77694292
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73939071
51NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.68823435
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68387631
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68071594
54RARB_27405468_Chip-Seq_BRAIN_Mouse1.66417240
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65355362
56DROSHA_22980978_ChIP-Seq_HELA_Human1.64618004
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.61727316
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58474479
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56195293
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.52394103
61SMAD4_21799915_ChIP-Seq_A2780_Human1.51927381
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.51115528
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50161202
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.49882395
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48786000
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45145134
67P300_19829295_ChIP-Seq_ESCs_Human1.43995560
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.42689773
69JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.42563858
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.41716726
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41671733
72HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40650515
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40507151
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39072514
75NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37586838
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37394867
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.34589537
78SOX2_16153702_ChIP-ChIP_HESCs_Human1.34109089
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.33741425
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33702807
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32059972
82HTT_18923047_ChIP-ChIP_STHdh_Human1.31853635
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31214772
84NANOG_16153702_ChIP-ChIP_HESCs_Human1.26465931
85MYC_18940864_ChIP-ChIP_HL60_Human1.26379923
86SOX2_21211035_ChIP-Seq_LN229_Gbm1.25855096
87NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25068615
88AR_25329375_ChIP-Seq_VCAP_Human1.24578819
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24522699
90POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24358849
91FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24329750
92NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.24003540
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23402359
94TTF2_22483619_ChIP-Seq_HELA_Human1.22439673
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22156029
96PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21782753
97E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21542297
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21101172
99MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20413458
100IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19648616
101DCP1A_22483619_ChIP-Seq_HELA_Human1.19186892
102MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18761895
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.18388668
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18041742
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17240186
106SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16914908
107STAT3_23295773_ChIP-Seq_U87_Human1.16787327
108POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16747058
109MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16051597
110CBX2_27304074_Chip-Seq_ESCs_Mouse1.15666981
111TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14804193
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14771870
113POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11451897
114ZNF274_21170338_ChIP-Seq_K562_Hela1.10313861
115MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09857925
116GABP_19822575_ChIP-Seq_HepG2_Human1.08706451
117BCAT_22108803_ChIP-Seq_LS180_Human1.08674330
118MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08290775
119VDR_22108803_ChIP-Seq_LS180_Human1.07191986
120IRF1_19129219_ChIP-ChIP_H3396_Human1.06849240
121ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06835468
122ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06586559
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06360220
124SOX9_26525672_Chip-Seq_HEART_Mouse1.05517448
125PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05386407
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04904858
127AR_19668381_ChIP-Seq_PC3_Human1.04795521
128HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.04630939
129XRN2_22483619_ChIP-Seq_HELA_Human1.02710776
130DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01267593
131ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00600801
132ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00337158
133MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00266225
134RING1B_27294783_Chip-Seq_ESCs_Mouse0.99884634
135POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99877643
136IGF1R_20145208_ChIP-Seq_DFB_Human0.99670455
137FLI1_27457419_Chip-Seq_LIVER_Mouse0.99452030
138SOX17_20123909_ChIP-Seq_XEN_Mouse0.99300628
139TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98683174
140TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98535548
141NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98488948
142RUNX2_22187159_ChIP-Seq_PCA_Human0.96083595
143CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95502171
144CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95393985
145CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95339652
146VDR_23849224_ChIP-Seq_CD4+_Human0.95039391
147TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.94639397
148SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93983482
149TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93609716
150BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93413067
151BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93363308
152SMAD4_21741376_ChIP-Seq_HESCs_Human0.93317645
153FOXA2_19822575_ChIP-Seq_HepG2_Human0.93010248
154PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.92964074
155FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92550474
156CBP_20019798_ChIP-Seq_JUKART_Human0.91743178
157IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91743178
158TCF4_23295773_ChIP-Seq_U87_Human0.91702117
159TP63_19390658_ChIP-ChIP_HaCaT_Human0.91408347
160ARNT_22903824_ChIP-Seq_MCF-7_Human0.90913726
161SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.90752855
162TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90654868
163ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89793382
164FOXP3_21729870_ChIP-Seq_TREG_Human0.89748186
165ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88112225
166AHR_22903824_ChIP-Seq_MCF-7_Human0.87105799
167P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86397667
168WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85451594
169ER_23166858_ChIP-Seq_MCF-7_Human0.84453939
170EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84260929
171TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84135328
172SMAD4_21741376_ChIP-Seq_EPCs_Human0.84001901
173MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83502445
174NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83378168
175NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83378168
176RNF2_27304074_Chip-Seq_NSC_Mouse0.83047288

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.62514972
2MP0005360_urolithiasis3.85092500
3MP0004859_abnormal_synaptic_plasticity3.48549394
4MP0005085_abnormal_gallbladder_physiolo3.45435164
5MP0005365_abnormal_bile_salt3.40860721
6MP0008875_abnormal_xenobiotic_pharmacok2.97456970
7MP0003880_abnormal_central_pattern2.80854966
8MP0003635_abnormal_synaptic_transmissio2.71088955
9MP0004270_analgesia2.47596214
10MP0001968_abnormal_touch/_nociception2.38762599
11MP0003329_amyloid_beta_deposits2.37880970
12MP0009745_abnormal_behavioral_response2.34363984
13MP0010094_abnormal_chromosome_stability2.28703518
14MP0002063_abnormal_learning/memory/cond2.24586843
15MP0002064_seizures2.23744888
16MP0010329_abnormal_lipoprotein_level2.15342319
17MP0003136_yellow_coat_color2.15040022
18MP0003890_abnormal_embryonic-extraembry2.05736986
19MP0002736_abnormal_nociception_after2.00146868
20MP0009046_muscle_twitch1.99688915
21MP0002572_abnormal_emotion/affect_behav1.99211660
22MP0003252_abnormal_bile_duct1.97546394
23MP0003693_abnormal_embryo_hatching1.96852066
24MP0008057_abnormal_DNA_replication1.95607717
25MP0004957_abnormal_blastocyst_morpholog1.93896913
26MP0001486_abnormal_startle_reflex1.91237045
27MP0002734_abnormal_mechanical_nocicepti1.88937316
28MP0002938_white_spotting1.88788296
29MP0008058_abnormal_DNA_repair1.87397404
30MP0001984_abnormal_olfaction1.87366417
31MP0002272_abnormal_nervous_system1.85316404
32MP0005646_abnormal_pituitary_gland1.85063851
33MP0008932_abnormal_embryonic_tissue1.84737426
34MP0002735_abnormal_chemical_nociception1.82451014
35MP0003111_abnormal_nucleus_morphology1.81813199
36MP0006276_abnormal_autonomic_nervous1.79854426
37MP0003937_abnormal_limbs/digits/tail_de1.79401821
38MP0005083_abnormal_biliary_tract1.79224036
39MP0003121_genomic_imprinting1.75314509
40MP0002822_catalepsy1.74034789
41MP0005551_abnormal_eye_electrophysiolog1.72163741
42MP0001293_anophthalmia1.69290300
43MP0004858_abnormal_nervous_system1.68313988
44MP0010030_abnormal_orbit_morphology1.68157316
45MP0003941_abnormal_skin_development1.67559148
46MP0006292_abnormal_olfactory_placode1.66664868
47MP0001502_abnormal_circadian_rhythm1.66171231
48MP0005332_abnormal_amino_acid1.65923783
49MP0009780_abnormal_chondrocyte_physiolo1.63995225
50MP0002733_abnormal_thermal_nociception1.62291198
51MP0008877_abnormal_DNA_methylation1.60467675
52MP0003690_abnormal_glial_cell1.60350140
53MP0001440_abnormal_grooming_behavior1.57673615
54MP0002909_abnormal_adrenal_gland1.57646414
55MP0002067_abnormal_sensory_capabilities1.55112894
56MP0005423_abnormal_somatic_nervous1.54261017
57MP0000604_amyloidosis1.53937517
58MP0003077_abnormal_cell_cycle1.53686730
59MP0002697_abnormal_eye_size1.53101365
60MP0000537_abnormal_urethra_morphology1.51583839
61MP0003123_paternal_imprinting1.50219671
62MP0002102_abnormal_ear_morphology1.46300662
63MP0004885_abnormal_endolymph1.46276942
64MP0003195_calcinosis1.46160248
65MP0003119_abnormal_digestive_system1.45777449
66MP0002233_abnormal_nose_morphology1.45707261
67MP0004133_heterotaxia1.43882378
68MP0000566_synostosis1.42053374
69MP0001299_abnormal_eye_distance/1.41855044
70MP0003806_abnormal_nucleotide_metabolis1.41713981
71MP0009840_abnormal_foam_cell1.41680467
72MP0001501_abnormal_sleep_pattern1.39904144
73MP0001970_abnormal_pain_threshold1.36088073
74MP0003868_abnormal_feces_composition1.35584040
75MP0002557_abnormal_social/conspecific_i1.35379644
76MP0005187_abnormal_penis_morphology1.33243950
77MP0001666_abnormal_nutrient_absorption1.31593223
78MP0001529_abnormal_vocalization1.30731450
79MP0004142_abnormal_muscle_tone1.29569259
80MP0002090_abnormal_vision1.28511205
81MP0002118_abnormal_lipid_homeostasis1.28315717
82MP0000778_abnormal_nervous_system1.27552020
83MP0004924_abnormal_behavior1.26284325
84MP0005386_behavior/neurological_phenoty1.26284325
85MP0002184_abnormal_innervation1.25866520
86MP0002084_abnormal_developmental_patter1.23601736
87MP0001286_abnormal_eye_development1.22148446
88MP0003861_abnormal_nervous_system1.20492428
89MP0002876_abnormal_thyroid_physiology1.18684198
90MP0003633_abnormal_nervous_system1.15216587
91MP0000647_abnormal_sebaceous_gland1.15113516
92MP0003567_abnormal_fetal_cardiomyocyte1.14679109
93MP0005645_abnormal_hypothalamus_physiol1.13827184
94MP0002751_abnormal_autonomic_nervous1.12555622
95MP0000955_abnormal_spinal_cord1.11904469
96MP0008569_lethality_at_weaning1.11251793
97MP0009672_abnormal_birth_weight1.10708270
98MP0002085_abnormal_embryonic_tissue1.10286732
99MP0005499_abnormal_olfactory_system1.09189785
100MP0005394_taste/olfaction_phenotype1.09189785
101MP0003315_abnormal_perineum_morphology1.09142004
102MP0008789_abnormal_olfactory_epithelium1.08126954
103MP0002882_abnormal_neuron_morphology1.07958452
104MP0000049_abnormal_middle_ear1.07564391
105MP0001188_hyperpigmentation1.05559910
106MP0005584_abnormal_enzyme/coenzyme_acti1.04921524
107MP0003283_abnormal_digestive_organ1.04898196
108MP0002229_neurodegeneration1.04813448
109MP0003787_abnormal_imprinting1.04678469
110MP0001905_abnormal_dopamine_level1.04172868
111MP0003755_abnormal_palate_morphology1.04013581
112MP0003718_maternal_effect1.03832162
113MP0004019_abnormal_vitamin_homeostasis1.02561807
114MP0002066_abnormal_motor_capabilities/c1.02408472
115MP0003631_nervous_system_phenotype1.02102042
116MP0003385_abnormal_body_wall1.01966838
117MP0004811_abnormal_neuron_physiology0.98715910
118MP0008007_abnormal_cellular_replicative0.97884931
119MP0003942_abnormal_urinary_system0.97174584
120MP0002234_abnormal_pharynx_morphology0.97168421
121MP0005391_vision/eye_phenotype0.97116885
122MP0005535_abnormal_body_temperature0.96494325
123MP0003938_abnormal_ear_development0.96010704
124MP0003634_abnormal_glial_cell0.95894933
125MP0003011_delayed_dark_adaptation0.95768502
126MP0008872_abnormal_physiological_respon0.95730995
127MP0001672_abnormal_embryogenesis/_devel0.95581252
128MP0005380_embryogenesis_phenotype0.95581252
129MP0003183_abnormal_peptide_metabolism0.94678510
130MP0005171_absent_coat_pigmentation0.94238380
131MP0005248_abnormal_Harderian_gland0.93184025
132MP0000639_abnormal_adrenal_gland0.93029780
133MP0003879_abnormal_hair_cell0.92578955
134MP0003632_abnormal_nervous_system0.92534853
135MP0009697_abnormal_copulation0.92300816
136MP0001730_embryonic_growth_arrest0.92074623
137MP0001697_abnormal_embryo_size0.91466573
138MP0002092_abnormal_eye_morphology0.91231275
139MP0002069_abnormal_eating/drinking_beha0.90448794
140MP0001346_abnormal_lacrimal_gland0.90385115
141MP0009703_decreased_birth_body0.90011298
142MP0000372_irregular_coat_pigmentation0.89522254
143MP0001177_atelectasis0.87736338
144MP0000516_abnormal_urinary_system0.86888363
145MP0005367_renal/urinary_system_phenotyp0.86888363
146MP0003122_maternal_imprinting0.86443053
147MP0003935_abnormal_craniofacial_develop0.85615145
148MP0002111_abnormal_tail_morphology0.84040502
149MP0004043_abnormal_pH_regulation0.82272426
150MP0004197_abnormal_fetal_growth/weight/0.81930538
151MP0003984_embryonic_growth_retardation0.80386778
152MP0000609_abnormal_liver_physiology0.80010815
153MP0000631_abnormal_neuroendocrine_gland0.79026685
154MP0002088_abnormal_embryonic_growth/wei0.79024032
155MP0002638_abnormal_pupillary_reflex0.78542815
156MP0000428_abnormal_craniofacial_morphol0.75504576
157MP0002210_abnormal_sex_determination0.75369552
158MP0001485_abnormal_pinna_reflex0.75099910
159MP0005253_abnormal_eye_physiology0.75009440
160MP0005647_abnormal_sex_gland0.73993679
161MP0002152_abnormal_brain_morphology0.73848325
162MP0000920_abnormal_myelination0.73749526
163MP0002078_abnormal_glucose_homeostasis0.69838075
164MP0002752_abnormal_somatic_nervous0.68043593
165MP0008874_decreased_physiological_sensi0.66380078
166MP0001963_abnormal_hearing_physiology0.66081959
167MP0005319_abnormal_enzyme/_coenzyme0.65805316
168MP0004742_abnormal_vestibular_system0.65768357
169MP0002138_abnormal_hepatobiliary_system0.65283525
170MP0001764_abnormal_homeostasis0.64388867
171MP0006035_abnormal_mitochondrial_morpho0.64359204
172MP0006072_abnormal_retinal_apoptosis0.63026563

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.61807287
2Deep venous thrombosis (HP:0002625)4.32826835
3Intrahepatic cholestasis (HP:0001406)4.17810557
4Focal motor seizures (HP:0011153)3.97184611
5Xanthomatosis (HP:0000991)3.81486628
6Hyperlipoproteinemia (HP:0010980)3.80230056
7Hypobetalipoproteinemia (HP:0003563)3.78755614
8Myokymia (HP:0002411)3.68108334
9Prolonged partial thromboplastin time (HP:0003645)3.56296494
10Hyperventilation (HP:0002883)3.37493304
11Abnormality of monocarboxylic acid metabolism (HP:0010996)3.36787400
12Epileptic encephalopathy (HP:0200134)3.36156796
13Neurofibrillary tangles (HP:0002185)3.27339196
14Conjugated hyperbilirubinemia (HP:0002908)3.14559083
15Focal seizures (HP:0007359)3.11119464
16Ketosis (HP:0001946)3.05442315
17Abnormality of the labia minora (HP:0012880)3.03735371
18Status epilepticus (HP:0002133)2.91919875
19Hypolipoproteinemia (HP:0010981)2.86065301
20Cerebral inclusion bodies (HP:0100314)2.82919015
21Complement deficiency (HP:0004431)2.82412571
22Progressive cerebellar ataxia (HP:0002073)2.80274657
23Pheochromocytoma (HP:0002666)2.79182129
24Generalized tonic-clonic seizures (HP:0002069)2.77360001
25Ketoacidosis (HP:0001993)2.77045144
26Absence seizures (HP:0002121)2.75532004
27Cortical dysplasia (HP:0002539)2.74845693
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.73115955
29Visual hallucinations (HP:0002367)2.73041836
30Megalencephaly (HP:0001355)2.65853726
31Hyperammonemia (HP:0001987)2.65045292
32Epidermoid cyst (HP:0200040)2.65001741
33Hyperglycinemia (HP:0002154)2.64510128
34Colon cancer (HP:0003003)2.62689332
35Hepatoblastoma (HP:0002884)2.61705314
36Chromsome breakage (HP:0040012)2.59864960
37Atonic seizures (HP:0010819)2.59545160
38Hypoalphalipoproteinemia (HP:0003233)2.56215312
39Febrile seizures (HP:0002373)2.55199397
40Action tremor (HP:0002345)2.51554207
41Supranuclear gaze palsy (HP:0000605)2.47132037
42Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.46524902
43Neuroendocrine neoplasm (HP:0100634)2.45758225
44Dialeptic seizures (HP:0011146)2.45582315
45Abnormality of methionine metabolism (HP:0010901)2.42275547
46Abnormality of serine family amino acid metabolism (HP:0010894)2.41648410
47Abnormality of glycine metabolism (HP:0010895)2.41648410
48Cholecystitis (HP:0001082)2.40789502
49Abnormal gallbladder physiology (HP:0012438)2.40789502
50Epileptiform EEG discharges (HP:0011182)2.40072256
51Abnormality of the lower motor neuron (HP:0002366)2.38293800
52Dysdiadochokinesis (HP:0002075)2.38289081
53EEG with generalized epileptiform discharges (HP:0011198)2.37224234
54Meckel diverticulum (HP:0002245)2.35612355
55Volvulus (HP:0002580)2.34907241
56Bifid tongue (HP:0010297)2.31301457
57Abnormality of sulfur amino acid metabolism (HP:0004339)2.30866126
58Scanning speech (HP:0002168)2.30433733
59Sensorimotor neuropathy (HP:0007141)2.29707197
60Intestinal atresia (HP:0011100)2.28824569
61Abnormality of the ileum (HP:0001549)2.27149279
62Hypsarrhythmia (HP:0002521)2.27136245
63Fat malabsorption (HP:0002630)2.26856463
64Gout (HP:0001997)2.23444800
65Blue irides (HP:0000635)2.23380450
66Impaired vibration sensation in the lower limbs (HP:0002166)2.22061906
67Abnormal lung lobation (HP:0002101)2.21889960
68Abnormality of the common coagulation pathway (HP:0010990)2.21646968
69Hyperglycinuria (HP:0003108)2.21308672
70Ankle clonus (HP:0011448)2.21274687
71Abnormality of aspartate family amino acid metabolism (HP:0010899)2.20193556
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.17584419
73Torticollis (HP:0000473)2.16274175
74Anxiety (HP:0000739)2.15827302
75Spastic gait (HP:0002064)2.15040815
76Termporal pattern (HP:0011008)2.12740050
77Insidious onset (HP:0003587)2.12740050
78Depression (HP:0000716)2.11182589
79Abnormality of glutamine family amino acid metabolism (HP:0010902)2.10604163
80Abnormality of chromosome stability (HP:0003220)2.10419509
81Intention tremor (HP:0002080)2.10375891
82Neonatal onset (HP:0003623)2.09898242
83Genital tract atresia (HP:0001827)2.08093611
84Absent radius (HP:0003974)2.07676608
85Agitation (HP:0000713)2.06942138
86Vaginal atresia (HP:0000148)2.06889886
87Truncal ataxia (HP:0002078)2.06810736
88Abnormality of the astrocytes (HP:0100707)2.02980372
89Astrocytoma (HP:0009592)2.02980372
90Abnormality of the corticospinal tract (HP:0002492)2.02422172
91Excessive salivation (HP:0003781)2.02241647
92Drooling (HP:0002307)2.02241647
93Gait imbalance (HP:0002141)2.02233669
94Abnormal eating behavior (HP:0100738)2.01925778
95Focal dystonia (HP:0004373)2.01789444
96Congenital primary aphakia (HP:0007707)2.00630524
97Delayed CNS myelination (HP:0002188)1.99892173
98Hypoglycemic seizures (HP:0002173)1.99291956
99Glioma (HP:0009733)1.98969454
100Postural instability (HP:0002172)1.98884965
101Craniofacial dystonia (HP:0012179)1.98609293
102Absent forearm bone (HP:0003953)1.98506612
103Aplasia involving forearm bones (HP:0009822)1.98506612
104Hyperbilirubinemia (HP:0002904)1.97611146
105Hyperinsulinemic hypoglycemia (HP:0000825)1.97342547
106Dysmetria (HP:0001310)1.97227237
107Increased nuchal translucency (HP:0010880)1.97053635
108Generalized myoclonic seizures (HP:0002123)1.96737203
109Morphological abnormality of the pyramidal tract (HP:0002062)1.96182928
110Medulloblastoma (HP:0002885)1.95654839
111Ependymoma (HP:0002888)1.95515091
112Polyphagia (HP:0002591)1.94597851
113Hypoglycemic coma (HP:0001325)1.91764017
114Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.90392493
115Tetraplegia (HP:0002445)1.89429907
116Medial flaring of the eyebrow (HP:0010747)1.89099273
117Abnormality of the intrinsic pathway (HP:0010989)1.88307781
118Joint hemorrhage (HP:0005261)1.88151263
119Anophthalmia (HP:0000528)1.87778923
120Abnormal gallbladder morphology (HP:0012437)1.87746057
121Abnormal social behavior (HP:0012433)1.87566468
122Impaired social interactions (HP:0000735)1.87566468
123Preaxial hand polydactyly (HP:0001177)1.87555917
124Nephrogenic diabetes insipidus (HP:0009806)1.86540546
125Skin nodule (HP:0200036)1.86265250
126Irritability (HP:0000737)1.85087570
127Oligodactyly (hands) (HP:0001180)1.84421452
128Metabolic acidosis (HP:0001942)1.82248258
129Urinary urgency (HP:0000012)1.81914574
130Hemiparesis (HP:0001269)1.80661575
131Facial cleft (HP:0002006)1.79871711
132Birth length less than 3rd percentile (HP:0003561)1.79227816
133Cholelithiasis (HP:0001081)1.79193594
134Gastrointestinal atresia (HP:0002589)1.79138799
135Pancreatic islet-cell hyperplasia (HP:0004510)1.77644613
136Renal hypoplasia (HP:0000089)1.77517988
137Esophageal atresia (HP:0002032)1.77456299
138Spontaneous abortion (HP:0005268)1.76892773
139Impaired vibratory sensation (HP:0002495)1.76524286
140Aplasia/Hypoplasia of the tibia (HP:0005772)1.75086637
141Pancreatic fibrosis (HP:0100732)1.74831952
142Rhabdomyosarcoma (HP:0002859)1.74139454
143Nephroblastoma (Wilms tumor) (HP:0002667)1.73885610
144True hermaphroditism (HP:0010459)1.72271480
145Triphalangeal thumb (HP:0001199)1.71461863
146Aqueductal stenosis (HP:0002410)1.71054967
147Poor coordination (HP:0002370)1.70359909
148Septo-optic dysplasia (HP:0100842)1.68807256
149Embryonal renal neoplasm (HP:0011794)1.68785664
150Short tibia (HP:0005736)1.67902559
151Abnormality of the duodenum (HP:0002246)1.67147945
152Absent eyebrow (HP:0002223)1.66254926
153Broad foot (HP:0001769)1.62320479
154Cutaneous finger syndactyly (HP:0010554)1.61577089
155High anterior hairline (HP:0009890)1.59114404
156Supernumerary spleens (HP:0009799)1.58236905
157Abnormality of the preputium (HP:0100587)1.57753502
158Aplasia/Hypoplasia of the sternum (HP:0006714)1.57407375
159Labial hypoplasia (HP:0000066)1.57372223
160Sloping forehead (HP:0000340)1.57117536
161Micropenis (HP:0000054)1.57088710
162Hypoplastic pelvis (HP:0008839)1.56964097
163Hypoplastic female external genitalia (HP:0012815)1.55569776
164Pancreatic cysts (HP:0001737)1.54500202
165Abnormality of the carotid arteries (HP:0005344)1.54114110
166Postaxial hand polydactyly (HP:0001162)1.53762928
167Stenosis of the external auditory canal (HP:0000402)1.52808387
168Duodenal stenosis (HP:0100867)1.52759258
169Small intestinal stenosis (HP:0012848)1.52759258
170Double outlet right ventricle (HP:0001719)1.52242015
171Congenital malformation of the right heart (HP:0011723)1.52242015
172Dandy-Walker malformation (HP:0001305)1.51627900
173Preaxial foot polydactyly (HP:0001841)1.51297293
174Postnatal microcephaly (HP:0005484)1.50972254
175Abnormality of serum amino acid levels (HP:0003112)1.50310216
176Horseshoe kidney (HP:0000085)1.48515329
177Sclerocornea (HP:0000647)1.47831341
178Retinal dysplasia (HP:0007973)1.47740830
179Hemivertebrae (HP:0002937)1.47062169
180Cutaneous syndactyly (HP:0012725)1.46814147
181Lissencephaly (HP:0001339)1.46347288
182Bicornuate uterus (HP:0000813)1.46111186
183Occipital encephalocele (HP:0002085)1.45318882
184Bilateral microphthalmos (HP:0007633)1.45309631
185Postaxial foot polydactyly (HP:0001830)1.45016640
186Abnormality of midbrain morphology (HP:0002418)1.44797924
187Molar tooth sign on MRI (HP:0002419)1.44797924
188Abnormality of the parathyroid morphology (HP:0011766)1.44493279
189Ectopic kidney (HP:0000086)1.44188137
190Acute encephalopathy (HP:0006846)1.43424173
191Oligodactyly (HP:0012165)1.42910486

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.74553535
2EPHA43.63884789
3CASK3.26971264
4MARK12.85527045
5TRIM282.79843629
6CDC72.63869139
7BUB12.60005270
8SRPK12.58438183
9MAP3K42.56752056
10NTRK22.46002708
11MINK12.44779711
12WEE12.39104798
13LMTK22.37653777
14MAP3K92.37404126
15DAPK22.32214292
16TTK2.31310005
17MAP2K42.29797553
18MAP2K72.22793097
19TSSK62.19583269
20PBK2.17348405
21PNCK2.15370597
22MKNK22.05195807
23PLK31.87137832
24MKNK11.86318976
25NTRK11.81774042
26PRPF4B1.80562484
27PHKG11.71659053
28PHKG21.71659053
29SGK4941.69892993
30SGK2231.69892993
31PLK41.69797868
32PAK61.67684823
33ZAK1.61267844
34KSR11.55484569
35MAP3K121.54982548
36KSR21.49940372
37FGFR21.49927145
38SGK21.45504310
39PRKCG1.44388982
40PLK11.43668769
41TNIK1.43033616
42SIK11.40289964
43BMPR1B1.38344771
44TAF11.36264168
45BCKDK1.31411445
46MAPK131.25736871
47CDK51.25729421
48BRSK21.23300919
49ERBB31.19799554
50ERBB41.19714941
51PRKD31.17493627
52EIF2AK11.17009940
53CSNK1G21.16136482
54VRK21.14766115
55PAK31.13992286
56STK161.11819272
57PLK21.11623682
58GRK51.10973787
59BRSK11.09296607
60INSRR1.09072425
61SGK31.08819343
62AKT31.08358406
63MAP3K131.08288261
64OXSR11.08226561
65EIF2AK31.05156640
66NUAK11.04335233
67DAPK11.04188681
68MAP3K21.04175183
69VRK11.01786287
70LATS11.00911997
71CAMK2A0.99913241
72WNK30.98322168
73ATR0.97797652
74CHEK20.97259714
75STK38L0.96735856
76BCR0.96468636
77UHMK10.94651313
78MAP4K20.94065760
79CDK190.93773066
80CAMKK10.93365340
81BRD40.92208467
82RET0.89196219
83FGFR40.87683915
84NEK20.86510703
85SIK30.85703715
86CAMK2B0.82963825
87TYRO30.81989285
88PINK10.81897068
89PRKCH0.81613111
90DYRK1A0.80582507
91PRKCZ0.80475968
92CAMK2G0.79140637
93AURKB0.78657711
94ATM0.78583602
95MST40.76767532
96FER0.75220721
97CDK140.74618317
98CDK180.71988894
99CHEK10.67699180
100CDK150.67203599
101CSNK1G30.66869799
102PRKCE0.66087256
103CSNK1E0.66077816
104PASK0.65807903
105MAP3K70.65102247
106DYRK30.64060105
107MET0.63961690
108STK30.61152593
109ARAF0.59940448
110CDK10.57384887
111EPHB20.56675575
112CDK70.56130246
113CDK30.56013117
114SGK10.55565958
115FRK0.54793828
116SCYL20.54748891
117MAP2K10.54310652
118EIF2AK20.54226082
119ACVR1B0.53860241
120CAMKK20.53515524
121CDK11A0.52515076
122MAP3K10.52295385
123STK380.52240191
124STK390.51874851
125PRKDC0.50769951
126RPS6KA30.50751122
127CAMK2D0.50109928
128ADRBK10.48111241
129AURKA0.47718302
130PRKACG0.47334142
131FGFR10.46604911
132CDK20.45924973
133NEK10.45316466
134ERBB20.45165722
135CSNK1G10.43880201
136CSNK1A1L0.43577149
137GRK10.43470901
138PRKCA0.43419702
139MAPK120.43338207
140PRKACA0.42641817
141NME10.42241109
142CSNK1D0.41216988
143CDK80.40707314
144PRKCB0.40338862
145CSNK1A10.40314973
146PDPK10.40232132
147LIMK10.39286525
148LATS20.37604659
149SIK20.37172909
150PKN10.37029230
151CAMK1G0.36053294
152PRKAA10.35338307
153FES0.35050951
154FYN0.35029567
155WNK40.33819995
156DYRK20.33400370

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.60001626
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.18429078
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.95633643
4Mismatch repair_Homo sapiens_hsa034302.65248095
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.59551385
6DNA replication_Homo sapiens_hsa030302.43755802
7Arginine biosynthesis_Homo sapiens_hsa002202.26146128
8Butanoate metabolism_Homo sapiens_hsa006502.22698327
9Non-homologous end-joining_Homo sapiens_hsa034502.19593532
10Protein export_Homo sapiens_hsa030602.16943908
11Nicotine addiction_Homo sapiens_hsa050332.15143910
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.12670735
13Fatty acid degradation_Homo sapiens_hsa000712.00161836
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91571556
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.90568027
16Fatty acid metabolism_Homo sapiens_hsa012121.87544254
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.84217661
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.84168913
19Synaptic vesicle cycle_Homo sapiens_hsa047211.82487328
20Fanconi anemia pathway_Homo sapiens_hsa034601.79453826
21Tryptophan metabolism_Homo sapiens_hsa003801.75370167
22GABAergic synapse_Homo sapiens_hsa047271.75263786
23Proteasome_Homo sapiens_hsa030501.71375171
24Homologous recombination_Homo sapiens_hsa034401.69870108
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68297147
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68167000
27Cell cycle_Homo sapiens_hsa041101.64868708
28Bile secretion_Homo sapiens_hsa049761.64858030
29RNA transport_Homo sapiens_hsa030131.62810133
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.61274432
31Complement and coagulation cascades_Homo sapiens_hsa046101.56882108
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.54911288
33RNA polymerase_Homo sapiens_hsa030201.51284270
34Fatty acid elongation_Homo sapiens_hsa000621.47982127
35Peroxisome_Homo sapiens_hsa041461.47060068
36Base excision repair_Homo sapiens_hsa034101.46675394
37Propanoate metabolism_Homo sapiens_hsa006401.45864968
38Spliceosome_Homo sapiens_hsa030401.44518467
39Nucleotide excision repair_Homo sapiens_hsa034201.42881333
40One carbon pool by folate_Homo sapiens_hsa006701.41435745
41PPAR signaling pathway_Homo sapiens_hsa033201.38344700
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.35710985
43Fatty acid biosynthesis_Homo sapiens_hsa000611.34919709
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34851692
45Pyruvate metabolism_Homo sapiens_hsa006201.32263572
46Steroid biosynthesis_Homo sapiens_hsa001001.30976775
47Basal transcription factors_Homo sapiens_hsa030221.27770138
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.26142177
49Glutamatergic synapse_Homo sapiens_hsa047241.24009364
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23557669
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23239148
52Circadian entrainment_Homo sapiens_hsa047131.19934450
53Morphine addiction_Homo sapiens_hsa050321.19829422
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15180723
55Insulin secretion_Homo sapiens_hsa049111.13125570
56RNA degradation_Homo sapiens_hsa030181.09644299
57Oxidative phosphorylation_Homo sapiens_hsa001901.09460992
58Sulfur metabolism_Homo sapiens_hsa009201.09422733
59Chemical carcinogenesis_Homo sapiens_hsa052041.05430307
60Parkinsons disease_Homo sapiens_hsa050121.05319118
61mRNA surveillance pathway_Homo sapiens_hsa030151.05014917
62Oocyte meiosis_Homo sapiens_hsa041141.04358937
63beta-Alanine metabolism_Homo sapiens_hsa004101.02304261
64Histidine metabolism_Homo sapiens_hsa003401.01353370
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00163970
66Amphetamine addiction_Homo sapiens_hsa050311.00117428
67Hippo signaling pathway_Homo sapiens_hsa043900.99207899
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98971752
69Olfactory transduction_Homo sapiens_hsa047400.98506116
70Folate biosynthesis_Homo sapiens_hsa007900.97470315
71Huntingtons disease_Homo sapiens_hsa050160.97342733
72Phenylalanine metabolism_Homo sapiens_hsa003600.96860222
73Pyrimidine metabolism_Homo sapiens_hsa002400.96755372
74Tyrosine metabolism_Homo sapiens_hsa003500.96261983
75Dopaminergic synapse_Homo sapiens_hsa047280.94676265
76Basal cell carcinoma_Homo sapiens_hsa052170.92858998
77Biosynthesis of amino acids_Homo sapiens_hsa012300.88579752
78Long-term potentiation_Homo sapiens_hsa047200.88429241
79Cocaine addiction_Homo sapiens_hsa050300.88014356
80Collecting duct acid secretion_Homo sapiens_hsa049660.87647489
81Salivary secretion_Homo sapiens_hsa049700.87596937
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.87090803
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86961422
84Retinol metabolism_Homo sapiens_hsa008300.85276975
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84887696
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84787739
87Lysine degradation_Homo sapiens_hsa003100.83975009
88Taste transduction_Homo sapiens_hsa047420.82586916
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82263505
90Hedgehog signaling pathway_Homo sapiens_hsa043400.82188035
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80771274
92Purine metabolism_Homo sapiens_hsa002300.79585045
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78113045
94Carbon metabolism_Homo sapiens_hsa012000.77762959
95Vitamin B6 metabolism_Homo sapiens_hsa007500.76471106
96TGF-beta signaling pathway_Homo sapiens_hsa043500.73827794
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73526870
98Glutathione metabolism_Homo sapiens_hsa004800.72161165
99ABC transporters_Homo sapiens_hsa020100.71704733
100Serotonergic synapse_Homo sapiens_hsa047260.70004139
101Renin secretion_Homo sapiens_hsa049240.69669522
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69076009
103Starch and sucrose metabolism_Homo sapiens_hsa005000.66944318
104Wnt signaling pathway_Homo sapiens_hsa043100.66756399
105Gastric acid secretion_Homo sapiens_hsa049710.66590495
106Cholinergic synapse_Homo sapiens_hsa047250.66324994
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64210229
108Glycerolipid metabolism_Homo sapiens_hsa005610.64074187
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.63398281
110Metabolic pathways_Homo sapiens_hsa011000.63370919
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61702070
112Alzheimers disease_Homo sapiens_hsa050100.59941157
113N-Glycan biosynthesis_Homo sapiens_hsa005100.59820207
114Arginine and proline metabolism_Homo sapiens_hsa003300.59408220
115Long-term depression_Homo sapiens_hsa047300.59247003
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58288924
117Fat digestion and absorption_Homo sapiens_hsa049750.57390792
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57285475
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.56679604
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55883975
121Adherens junction_Homo sapiens_hsa045200.55661805
122Caffeine metabolism_Homo sapiens_hsa002320.55572113
123Tight junction_Homo sapiens_hsa045300.55432951
124Phototransduction_Homo sapiens_hsa047440.54294429
125Circadian rhythm_Homo sapiens_hsa047100.53834750
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51476357
127Prion diseases_Homo sapiens_hsa050200.51417968
128Vibrio cholerae infection_Homo sapiens_hsa051100.51147209
129Calcium signaling pathway_Homo sapiens_hsa040200.49253494
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49055134
131Thyroid hormone synthesis_Homo sapiens_hsa049180.48230419
132Vitamin digestion and absorption_Homo sapiens_hsa049770.46263870
133Glucagon signaling pathway_Homo sapiens_hsa049220.45603500
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.44826638
135p53 signaling pathway_Homo sapiens_hsa041150.44491757
136Selenocompound metabolism_Homo sapiens_hsa004500.44206571
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43052759
138Alcoholism_Homo sapiens_hsa050340.41017686
139Sulfur relay system_Homo sapiens_hsa041220.40547141
140Axon guidance_Homo sapiens_hsa043600.39342826
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39301163
142Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38669696
143Ovarian steroidogenesis_Homo sapiens_hsa049130.38250102
144cAMP signaling pathway_Homo sapiens_hsa040240.37864739
145Oxytocin signaling pathway_Homo sapiens_hsa049210.37167276
146Cardiac muscle contraction_Homo sapiens_hsa042600.35997769
147GnRH signaling pathway_Homo sapiens_hsa049120.35778882
148Gap junction_Homo sapiens_hsa045400.35019270

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