HACE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a HECT domain and ankyrin repeat-containing ubiquitin ligase. The encoded protein is involved in specific tagging of target proteins, leading to their subcellular localization or proteasomal degradation. The protein is a potential tumor suppressor and is involved in the pathophysiology of several tumors, including Wilm's tumor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ionotropic glutamate receptor signaling pathway (GO:0035235)4.10294784
2negative regulation of cytosolic calcium ion concentration (GO:0051481)3.97684688
3regulation of short-term neuronal synaptic plasticity (GO:0048172)3.87320706
4regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.80367986
5response to pheromone (GO:0019236)3.80222784
6behavioral response to nicotine (GO:0035095)3.76733611
7positive regulation of amino acid transport (GO:0051957)3.74434045
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.65289860
9pyrimidine nucleobase catabolic process (GO:0006208)3.61505666
10glutamate receptor signaling pathway (GO:0007215)3.60777027
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.60443763
12startle response (GO:0001964)3.55197214
13presynaptic membrane assembly (GO:0097105)3.54029922
14negative regulation of neurotransmitter secretion (GO:0046929)3.53656699
15synaptic transmission, glutamatergic (GO:0035249)3.49853499
16detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.48797696
17regulation of glutamate receptor signaling pathway (GO:1900449)3.43210398
18neuron-neuron synaptic transmission (GO:0007270)3.28628517
19retinal cone cell development (GO:0046549)3.25668754
20neuronal action potential propagation (GO:0019227)3.22534380
21gamma-aminobutyric acid transport (GO:0015812)3.21542776
22regulation of glutamate secretion (GO:0014048)3.21516609
23neural tube formation (GO:0001841)3.20685510
24presynaptic membrane organization (GO:0097090)3.20119114
25G-protein coupled receptor internalization (GO:0002031)3.17881915
26vocalization behavior (GO:0071625)3.15343469
27regulation of DNA endoreduplication (GO:0032875)3.13837468
28negative regulation of synaptic transmission, GABAergic (GO:0032229)3.09545411
29protein K11-linked deubiquitination (GO:0035871)3.04287483
30regulation of synaptic vesicle exocytosis (GO:2000300)3.03740022
31nucleobase catabolic process (GO:0046113)3.02437790
32negative regulation of dendrite morphogenesis (GO:0050774)3.02063696
33nonmotile primary cilium assembly (GO:0035058)2.98714280
34synaptic vesicle docking involved in exocytosis (GO:0016081)2.98330359
35negative regulation of amino acid transport (GO:0051956)2.97517207
36regulation of long-term neuronal synaptic plasticity (GO:0048169)2.96900378
37L-amino acid import (GO:0043092)2.96277035
38G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.94249007
39locomotory exploration behavior (GO:0035641)2.93424924
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.92917683
41cerebellar Purkinje cell differentiation (GO:0021702)2.87228963
42protein localization to synapse (GO:0035418)2.86788504
43detection of calcium ion (GO:0005513)2.86369114
44mechanosensory behavior (GO:0007638)2.82502623
45neuronal action potential (GO:0019228)2.82429942
46somatic diversification of immune receptors via somatic mutation (GO:0002566)2.81728511
47somatic hypermutation of immunoglobulin genes (GO:0016446)2.81728511
48piRNA metabolic process (GO:0034587)2.81634404
49gamma-aminobutyric acid signaling pathway (GO:0007214)2.81356229
50auditory behavior (GO:0031223)2.79452153
51neuron cell-cell adhesion (GO:0007158)2.79163164
52synaptic vesicle endocytosis (GO:0048488)2.77205130
53regulation of synaptic vesicle transport (GO:1902803)2.76329069
54long-term memory (GO:0007616)2.74325245
55protein polyglutamylation (GO:0018095)2.74007743
56synaptic vesicle maturation (GO:0016188)2.73983578
57DNA double-strand break processing (GO:0000729)2.73947460
58regulation of neuronal synaptic plasticity (GO:0048168)2.73741947
59response to auditory stimulus (GO:0010996)2.73245234
60detection of light stimulus involved in sensory perception (GO:0050962)2.70894627
61detection of light stimulus involved in visual perception (GO:0050908)2.70894627
62reflex (GO:0060004)2.70606524
63regulation of cilium movement (GO:0003352)2.70168353
64righting reflex (GO:0060013)2.69335751
65neurotransmitter-gated ion channel clustering (GO:0072578)2.67754202
66dentate gyrus development (GO:0021542)2.66472271
67long-term synaptic potentiation (GO:0060291)2.66066660
68positive regulation of neurotransmitter secretion (GO:0001956)2.65944545
69negative regulation of dendrite development (GO:2000171)2.65472674
70regulation of neurotransmitter secretion (GO:0046928)2.64891419
71fucose catabolic process (GO:0019317)2.64532193
72L-fucose metabolic process (GO:0042354)2.64532193
73L-fucose catabolic process (GO:0042355)2.64532193
74regulation of excitatory postsynaptic membrane potential (GO:0060079)2.64344983
75synaptic vesicle exocytosis (GO:0016079)2.63692756
76histone H3-K4 trimethylation (GO:0080182)2.63376148
77regulation of synapse maturation (GO:0090128)2.63287735
78detection of mechanical stimulus involved in sensory perception (GO:0050974)2.62266594
79cilium morphogenesis (GO:0060271)2.61498677
80photoreceptor cell maintenance (GO:0045494)2.61230538
81glutamate secretion (GO:0014047)2.60574447
82serotonin receptor signaling pathway (GO:0007210)2.56796033
83membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.55568156
84cAMP catabolic process (GO:0006198)2.54811927
85positive regulation of catecholamine secretion (GO:0033605)2.53131235
86proline transport (GO:0015824)2.52761758
87central nervous system neuron axonogenesis (GO:0021955)2.52108680
88auditory receptor cell stereocilium organization (GO:0060088)2.51251520
89microtubule anchoring (GO:0034453)2.50274011
90replication fork processing (GO:0031297)2.49630068
91cerebral cortex radially oriented cell migration (GO:0021799)2.47553091
92regulation of postsynaptic membrane potential (GO:0060078)2.46682544
93serotonin metabolic process (GO:0042428)2.46459241
94tryptophan catabolic process (GO:0006569)2.46435741
95indole-containing compound catabolic process (GO:0042436)2.46435741
96indolalkylamine catabolic process (GO:0046218)2.46435741
97establishment of protein localization to Golgi (GO:0072600)2.46315870
98regulation of synaptic transmission, glutamatergic (GO:0051966)2.46118137
99epithelial cilium movement (GO:0003351)2.45542653
100cilium organization (GO:0044782)2.45221516
101superoxide anion generation (GO:0042554)2.45034649
102cilium assembly (GO:0042384)2.44797392
103postsynaptic membrane organization (GO:0001941)2.44550953
104regulation of MHC class I biosynthetic process (GO:0045343)2.44008814
105kynurenine metabolic process (GO:0070189)2.42695347
106transmission of nerve impulse (GO:0019226)2.42630446
107regulation of neurotransmitter transport (GO:0051588)2.41011664
108negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.40263338
109negative regulation of translation, ncRNA-mediated (GO:0040033)2.40263338
110regulation of translation, ncRNA-mediated (GO:0045974)2.40263338
111regulation of dopamine secretion (GO:0014059)2.39938276
112positive regulation of synaptic transmission, GABAergic (GO:0032230)2.39827291
113otic vesicle formation (GO:0030916)2.39733571
114somite development (GO:0061053)2.39043929
115cyclic nucleotide catabolic process (GO:0009214)2.37665116
116histone H3-K36 demethylation (GO:0070544)2.37106492
117negative regulation of mast cell activation (GO:0033004)2.36931554
118regulation of platelet aggregation (GO:0090330)2.36794902
119regulation of synapse structural plasticity (GO:0051823)2.36619574
120regulation of action potential (GO:0098900)2.36023461
121hindbrain development (GO:0030902)2.35782656
122photoreceptor cell development (GO:0042461)2.35454947
123regulation of collateral sprouting (GO:0048670)2.35219713
124exploration behavior (GO:0035640)2.34910653
125positive regulation of neurotransmitter transport (GO:0051590)2.34594721
126regulation of sarcomere organization (GO:0060297)2.34550329
127dendritic spine morphogenesis (GO:0060997)2.34236532
128meiotic chromosome segregation (GO:0045132)2.34175640
129neuron recognition (GO:0008038)2.33642844
130regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.33281572
131tachykinin receptor signaling pathway (GO:0007217)2.32625255
132limb bud formation (GO:0060174)2.32092692
133indolalkylamine metabolic process (GO:0006586)2.31964919
134retinal ganglion cell axon guidance (GO:0031290)2.31273664
135positive regulation of membrane potential (GO:0045838)2.30787243
136axonal fasciculation (GO:0007413)2.30633604
137regulation of synaptic transmission, GABAergic (GO:0032228)2.30519831
138histone H3-K9 methylation (GO:0051567)2.30282708
139axoneme assembly (GO:0035082)2.28534127
140glycine transport (GO:0015816)2.26326406
141regulation of synaptic plasticity (GO:0048167)2.25046575
142amino acid import (GO:0043090)2.24569182
143inner ear receptor stereocilium organization (GO:0060122)2.23541747
144membrane depolarization (GO:0051899)2.23521036
145central nervous system projection neuron axonogenesis (GO:0021952)2.23504281
146positive regulation of fibroblast migration (GO:0010763)2.22493788
147positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.21925842
148membrane depolarization during action potential (GO:0086010)2.21429135
149glycosphingolipid biosynthetic process (GO:0006688)2.20648376
150mRNA splice site selection (GO:0006376)2.19523967
151behavioral response to ethanol (GO:0048149)2.19433596
152regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.18860303
153negative regulation of neurotransmitter transport (GO:0051589)2.17745078
154regulation of dendritic spine morphogenesis (GO:0061001)2.16797429
155positive regulation of dendritic spine morphogenesis (GO:0061003)2.15828224
156learning (GO:0007612)2.14747843
157neurotransmitter secretion (GO:0007269)2.14525875
158negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.14373158
159negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744)2.13367826
160prostate gland growth (GO:0060736)2.12406785
161regulation of dendritic spine development (GO:0060998)2.12387054

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.55380132
2GBX2_23144817_ChIP-Seq_PC3_Human4.21799450
3ZNF274_21170338_ChIP-Seq_K562_Hela2.57555559
4* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50694793
5VDR_22108803_ChIP-Seq_LS180_Human2.48126059
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.31306324
7* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.31271048
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15560790
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12584650
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.10753483
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09252653
12TAF15_26573619_Chip-Seq_HEK293_Human2.07023052
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.02627432
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02374834
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.01891954
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96917296
17FUS_26573619_Chip-Seq_HEK293_Human1.93082528
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.93026588
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.92399695
20* P300_19829295_ChIP-Seq_ESCs_Human1.91506885
21SMAD4_21799915_ChIP-Seq_A2780_Human1.89895206
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.86125791
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80504148
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.80444846
25IGF1R_20145208_ChIP-Seq_DFB_Human1.77889064
26NANOG_18555785_Chip-Seq_ESCs_Mouse1.77602584
27TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.76811113
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74757541
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.73393241
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72398761
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.71856685
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70021649
33E2F1_18555785_Chip-Seq_ESCs_Mouse1.69667438
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.69619261
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69424311
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.68213981
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66774707
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.63054341
39P53_22387025_ChIP-Seq_ESCs_Mouse1.61585111
40* REST_21632747_ChIP-Seq_MESCs_Mouse1.59987229
41EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.59144462
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58430189
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58430189
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58289366
45DROSHA_22980978_ChIP-Seq_HELA_Human1.58088960
46* EWS_26573619_Chip-Seq_HEK293_Human1.58053985
47AR_21572438_ChIP-Seq_LNCaP_Human1.58005926
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57982947
49* SMAD3_21741376_ChIP-Seq_EPCs_Human1.57832348
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57376346
51CMYC_18555785_Chip-Seq_ESCs_Mouse1.54909094
52STAT3_23295773_ChIP-Seq_U87_Human1.53646538
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.53632885
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51677681
55SUZ12_18555785_Chip-Seq_ESCs_Mouse1.50140030
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.50077598
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47908042
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46987154
59CBP_20019798_ChIP-Seq_JUKART_Human1.46987154
60TCF4_23295773_ChIP-Seq_U87_Human1.46064081
61* RNF2_27304074_Chip-Seq_NSC_Mouse1.45278220
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.45204070
63STAT3_18555785_Chip-Seq_ESCs_Mouse1.44587132
64* EZH2_27294783_Chip-Seq_NPCs_Mouse1.44284397
65SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.42719776
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42245343
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41373973
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41173729
69BCAT_22108803_ChIP-Seq_LS180_Human1.40959762
70TP53_16413492_ChIP-PET_HCT116_Human1.40620685
71P300_18555785_Chip-Seq_ESCs_Mouse1.40561691
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39362001
73MTF2_20144788_ChIP-Seq_MESCs_Mouse1.39246216
74NMYC_18555785_Chip-Seq_ESCs_Mouse1.39054323
75* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38925772
76* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38894240
77EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.37475768
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35369800
79SOX2_18555785_Chip-Seq_ESCs_Mouse1.35291104
80AR_25329375_ChIP-Seq_VCAP_Human1.33245000
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.32509866
82* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32107509
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31430048
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31025774
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30724050
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30268666
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30268666
88IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29579159
89OCT4_18555785_Chip-Seq_ESCs_Mouse1.28622441
90TCF4_22108803_ChIP-Seq_LS180_Human1.28588265
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27524284
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27402408
93RUNX1_27457419_Chip-Seq_LIVER_Mouse1.26112121
94POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25234963
95* FLI1_21867929_ChIP-Seq_TH2_Mouse1.24724729
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24330941
97EZH2_27294783_Chip-Seq_ESCs_Mouse1.23209511
98PU1_27457419_Chip-Seq_LIVER_Mouse1.23197201
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.22236248
100TP53_18474530_ChIP-ChIP_U2OS_Human1.22008225
101IRF1_19129219_ChIP-ChIP_H3396_Human1.21744740
102FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21374052
103RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21363378
104SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21156364
105ER_23166858_ChIP-Seq_MCF-7_Human1.19470993
106* RUNX2_22187159_ChIP-Seq_PCA_Human1.18564292
107KDM2B_26808549_Chip-Seq_REH_Human1.17852215
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16832143
109TAL1_26923725_Chip-Seq_HPCs_Mouse1.15655423
110CTCF_18555785_Chip-Seq_ESCs_Mouse1.15098193
111* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14734263
112ZFX_18555785_Chip-Seq_ESCs_Mouse1.14362567
113KLF4_18555785_Chip-Seq_ESCs_Mouse1.14306272
114SOX2_19829295_ChIP-Seq_ESCs_Human1.13885698
115NANOG_19829295_ChIP-Seq_ESCs_Human1.13885698
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13878378
117* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12352388
118CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12170951
119* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11585404
120* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11522761
121ESRRB_18555785_Chip-Seq_ESCs_Mouse1.11267224
122* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11105675
123* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10783531
124SMAD4_21741376_ChIP-Seq_EPCs_Human1.10764406
125* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10064016
126KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09369026
127SMAD1_18555785_Chip-Seq_ESCs_Mouse1.09344816
128SOX2_21211035_ChIP-Seq_LN229_Gbm1.09103416
129EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08744877
130RARB_27405468_Chip-Seq_BRAIN_Mouse1.08524917
131* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07525169
132TP53_22573176_ChIP-Seq_HFKS_Human1.07522060
133LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05244856
134TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04595458
135* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03886421
136* CRX_20693478_ChIP-Seq_RETINA_Mouse1.03324793
137HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03098560
138JUN_21703547_ChIP-Seq_K562_Human1.02933565

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.46089498
2MP0001188_hyperpigmentation3.94935335
3MP0003787_abnormal_imprinting3.85438807
4MP0003880_abnormal_central_pattern3.49832815
5MP0009745_abnormal_behavioral_response2.77981637
6MP0003635_abnormal_synaptic_transmissio2.77793764
7MP0001968_abnormal_touch/_nociception2.68674962
8MP0000569_abnormal_digit_pigmentation2.45703105
9MP0009046_muscle_twitch2.37590045
10MP0002735_abnormal_chemical_nociception2.33856763
11MP0002063_abnormal_learning/memory/cond2.32366993
12MP0002736_abnormal_nociception_after2.29738899
13MP0001486_abnormal_startle_reflex2.17085817
14MP0002572_abnormal_emotion/affect_behav2.15630944
15MP0005646_abnormal_pituitary_gland2.13197722
16MP0002064_seizures2.13053757
17MP0006292_abnormal_olfactory_placode2.11364548
18MP0005171_absent_coat_pigmentation2.05707849
19MP0002234_abnormal_pharynx_morphology2.00895176
20MP0005409_darkened_coat_color1.97661692
21MP0001501_abnormal_sleep_pattern1.96076284
22MP0005645_abnormal_hypothalamus_physiol1.90870567
23MP0002272_abnormal_nervous_system1.89529700
24MP0003121_genomic_imprinting1.85480283
25MP0006072_abnormal_retinal_apoptosis1.81956183
26MP0003890_abnormal_embryonic-extraembry1.78431945
27MP0003136_yellow_coat_color1.77551162
28MP0002822_catalepsy1.70705597
29MP0000566_synostosis1.62698740
30MP0002067_abnormal_sensory_capabilities1.60644920
31MP0002734_abnormal_mechanical_nocicepti1.57106222
32MP0004885_abnormal_endolymph1.53848445
33MP0008789_abnormal_olfactory_epithelium1.49374497
34MP0003122_maternal_imprinting1.49071369
35MP0008877_abnormal_DNA_methylation1.46923481
36MP0002557_abnormal_social/conspecific_i1.46101274
37MP0004270_analgesia1.45318237
38MP0000015_abnormal_ear_pigmentation1.39167537
39MP0000778_abnormal_nervous_system1.37815743
40MP0001529_abnormal_vocalization1.36962408
41MP0002102_abnormal_ear_morphology1.34558133
42MP0002163_abnormal_gland_morphology1.34052191
43MP0000383_abnormal_hair_follicle1.33294722
44MP0004215_abnormal_myocardial_fiber1.30082528
45MP0002184_abnormal_innervation1.28029738
46MP0003937_abnormal_limbs/digits/tail_de1.27828383
47MP0001440_abnormal_grooming_behavior1.26822364
48MP0001485_abnormal_pinna_reflex1.26338285
49MP0001984_abnormal_olfaction1.26080491
50MP0003941_abnormal_skin_development1.25703338
51MP0001970_abnormal_pain_threshold1.25628285
52MP0006276_abnormal_autonomic_nervous1.25304540
53MP0005174_abnormal_tail_pigmentation1.21192443
54MP0002233_abnormal_nose_morphology1.20718082
55MP0005187_abnormal_penis_morphology1.20578323
56MP0008569_lethality_at_weaning1.19053049
57MP0004924_abnormal_behavior1.18919283
58MP0005386_behavior/neurological_phenoty1.18919283
59MP0004145_abnormal_muscle_electrophysio1.18019503
60MP0001177_atelectasis1.17944532
61MP0004147_increased_porphyrin_level1.17865491
62MP0001502_abnormal_circadian_rhythm1.16374789
63MP0005423_abnormal_somatic_nervous1.16092545
64MP0000049_abnormal_middle_ear1.14795517
65MP0002751_abnormal_autonomic_nervous1.14053694
66MP0009697_abnormal_copulation1.13088177
67MP0002876_abnormal_thyroid_physiology1.12080226
68MP0003718_maternal_effect1.10137497
69MP0002160_abnormal_reproductive_system1.08775653
70MP0004043_abnormal_pH_regulation1.08693881
71MP0002733_abnormal_thermal_nociception1.08692257
72MP0002837_dystrophic_cardiac_calcinosis1.06664159
73MP0004133_heterotaxia1.06195907
74MP0004811_abnormal_neuron_physiology1.06101529
75MP0003119_abnormal_digestive_system1.05286710
76MP0010386_abnormal_urinary_bladder1.05034729
77MP0008961_abnormal_basal_metabolism1.04597306
78MP0003646_muscle_fatigue1.04468934
79MP0002095_abnormal_skin_pigmentation1.03298439
80MP0002277_abnormal_respiratory_mucosa1.02558485
81MP0003195_calcinosis1.02257867
82MP0005379_endocrine/exocrine_gland_phen1.01029582
83MP0001293_anophthalmia1.00886291
84MP0010678_abnormal_skin_adnexa0.97153271
85MP0003567_abnormal_fetal_cardiomyocyte0.96947504
86MP0000427_abnormal_hair_cycle0.96864628
87MP0004742_abnormal_vestibular_system0.94628907
88MP0001346_abnormal_lacrimal_gland0.93255160
89MP0005195_abnormal_posterior_eye0.92698386
90MP0004510_myositis0.91933889
91MP0005394_taste/olfaction_phenotype0.91855241
92MP0005499_abnormal_olfactory_system0.91855241
93MP0003123_paternal_imprinting0.90180563
94MP0001963_abnormal_hearing_physiology0.89037191
95MP0000372_irregular_coat_pigmentation0.87967614
96MP0004381_abnormal_hair_follicle0.87474248
97MP0001905_abnormal_dopamine_level0.84481061
98MP0002882_abnormal_neuron_morphology0.83844748
99MP0003698_abnormal_male_reproductive0.82454386
100MP0003879_abnormal_hair_cell0.82369846
101MP0005391_vision/eye_phenotype0.82310066
102MP0010094_abnormal_chromosome_stability0.82153574
103MP0000955_abnormal_spinal_cord0.81254203
104MP0000647_abnormal_sebaceous_gland0.80953729
105MP0008058_abnormal_DNA_repair0.80633032
106MP0000026_abnormal_inner_ear0.80057352
107MP0003633_abnormal_nervous_system0.79837884
108MP0005389_reproductive_system_phenotype0.77573013
109MP0003861_abnormal_nervous_system0.77381621
110MP0002066_abnormal_motor_capabilities/c0.77164683
111MP0005551_abnormal_eye_electrophysiolog0.77076773
112MP0003183_abnormal_peptide_metabolism0.76898660
113MP0004142_abnormal_muscle_tone0.76426197
114MP0008995_early_reproductive_senescence0.74859205
115MP0002638_abnormal_pupillary_reflex0.73818569
116MP0001986_abnormal_taste_sensitivity0.72581174
117MP0004484_altered_response_of0.72032995
118MP0003631_nervous_system_phenotype0.70684596
119MP0000631_abnormal_neuroendocrine_gland0.67439690
120MP0001835_abnormal_antigen_presentation0.61622732
121MP0008057_abnormal_DNA_replication0.58897451
122MP0002152_abnormal_brain_morphology0.58846602
123MP0005253_abnormal_eye_physiology0.58229926
124MP0002009_preneoplasia0.57879761
125MP0002938_white_spotting0.56536352
126MP0002752_abnormal_somatic_nervous0.55543192
127MP0005310_abnormal_salivary_gland0.55541977
128MP0008004_abnormal_stomach_pH0.55049445
129MP0001664_abnormal_digestion0.54589121
130MP0008872_abnormal_physiological_respon0.54193217
131MP0001186_pigmentation_phenotype0.54092776

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.50888864
2Febrile seizures (HP:0002373)4.87772471
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.55141246
4Chromsome breakage (HP:0040012)4.05388165
5Epileptic encephalopathy (HP:0200134)3.83036332
6Pancreatic cysts (HP:0001737)3.58173014
7Pancreatic fibrosis (HP:0100732)3.53362995
8True hermaphroditism (HP:0010459)3.45389646
9Focal seizures (HP:0007359)3.40510516
10Gait imbalance (HP:0002141)2.87329115
11Pendular nystagmus (HP:0012043)2.76079775
12Congenital stationary night blindness (HP:0007642)2.72912874
13Congenital primary aphakia (HP:0007707)2.72507766
14Abnormality of the renal cortex (HP:0011035)2.67011339
15Gaze-evoked nystagmus (HP:0000640)2.64808386
16Abnormal delayed hypersensitivity skin test (HP:0002963)2.63859262
17Abnormal hair whorl (HP:0010721)2.57193235
18Attenuation of retinal blood vessels (HP:0007843)2.56487392
19Intestinal atresia (HP:0011100)2.56433433
20Absent speech (HP:0001344)2.56359042
21Genital tract atresia (HP:0001827)2.55215758
22Protruding tongue (HP:0010808)2.55020886
23Colon cancer (HP:0003003)2.54749554
24Atonic seizures (HP:0010819)2.54652578
25Abolished electroretinogram (ERG) (HP:0000550)2.51077108
26Nephrogenic diabetes insipidus (HP:0009806)2.45613217
27Broad-based gait (HP:0002136)2.44406121
28Vaginal atresia (HP:0000148)2.43378190
29Absent/shortened dynein arms (HP:0200106)2.41063064
30Dynein arm defect of respiratory motile cilia (HP:0012255)2.41063064
31Aplasia/Hypoplasia of the tibia (HP:0005772)2.36295090
32Generalized tonic-clonic seizures (HP:0002069)2.35956266
33Duplicated collecting system (HP:0000081)2.31746433
34Chronic mucocutaneous candidiasis (HP:0002728)2.28609410
35Recurrent cutaneous fungal infections (HP:0011370)2.28609410
36Increased corneal curvature (HP:0100692)2.28408873
37Keratoconus (HP:0000563)2.28408873
38Progressive cerebellar ataxia (HP:0002073)2.27436069
39Abnormality of the renal collecting system (HP:0004742)2.26534901
40Poor coordination (HP:0002370)2.24331482
41Chorioretinal atrophy (HP:0000533)2.23662393
42Abnormality of incisor morphology (HP:0011063)2.23468423
43Absent rod-and cone-mediated responses on ERG (HP:0007688)2.21399226
44Aplasia/Hypoplasia of the tongue (HP:0010295)2.19593883
45Cystic liver disease (HP:0006706)2.19406571
46Bony spicule pigmentary retinopathy (HP:0007737)2.19149487
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.18944647
48Renal cortical cysts (HP:0000803)2.17423203
49Abnormality of the preputium (HP:0100587)2.16285066
50Abnormal rod and cone electroretinograms (HP:0008323)2.15680366
51Absent frontal sinuses (HP:0002688)2.14649689
52Excessive salivation (HP:0003781)2.14589679
53Drooling (HP:0002307)2.14589679
54Abnormal ciliary motility (HP:0012262)2.14268049
55Dialeptic seizures (HP:0011146)2.12899933
56Generalized hypopigmentation of hair (HP:0011358)2.11909371
57Ectopic kidney (HP:0000086)2.11094112
58Tubulointerstitial nephritis (HP:0001970)2.10677722
59Absence seizures (HP:0002121)2.05888441
60Fair hair (HP:0002286)2.05450805
61Abnormality of the nasal septum (HP:0000419)2.05126865
62Postaxial hand polydactyly (HP:0001162)2.02939444
63Panhypogammaglobulinemia (HP:0003139)2.02715966
64White forelock (HP:0002211)2.02114944
65Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.01993860
66Abnormality of DNA repair (HP:0003254)2.01454062
67Abnormal biliary tract physiology (HP:0012439)2.01251506
68Bile duct proliferation (HP:0001408)2.01251506
69Type II lissencephaly (HP:0007260)2.01055816
70Abnormality of the labia minora (HP:0012880)2.00917399
71Meckel diverticulum (HP:0002245)2.00391326
72Supernumerary spleens (HP:0009799)1.98570088
73Abnormality of chromosome stability (HP:0003220)1.98484788
74Type 2 muscle fiber atrophy (HP:0003554)1.97963103
75Inability to walk (HP:0002540)1.97955473
76Congenital hepatic fibrosis (HP:0002612)1.97473365
77Anencephaly (HP:0002323)1.96767490
78Hyperventilation (HP:0002883)1.96555806
79Clubbing of toes (HP:0100760)1.96160158
80Tubular atrophy (HP:0000092)1.95635166
81Lissencephaly (HP:0001339)1.95281634
82Hypomagnesemia (HP:0002917)1.92600264
83Chronic hepatic failure (HP:0100626)1.92396736
84Abnormality of the ileum (HP:0001549)1.91978826
85Blue irides (HP:0000635)1.91182703
86Sclerocornea (HP:0000647)1.89226807
87Absent eyebrow (HP:0002223)1.88272554
88Volvulus (HP:0002580)1.87643578
89Lip pit (HP:0100267)1.86566805
90Long nose (HP:0003189)1.86324527
91Abnormality of salivation (HP:0100755)1.86261334
92Prostate neoplasm (HP:0100787)1.83174700
93Retrobulbar optic neuritis (HP:0100654)1.81425767
94Optic neuritis (HP:0100653)1.81425767
95Short tibia (HP:0005736)1.81283134
96Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80721086
97Abnormality of alanine metabolism (HP:0010916)1.80721086
98Hyperalaninemia (HP:0003348)1.80721086
99Growth hormone deficiency (HP:0000824)1.78735576
100Small intestinal stenosis (HP:0012848)1.76978244
101Duodenal stenosis (HP:0100867)1.76978244
102Pachygyria (HP:0001302)1.76757596
103Specific learning disability (HP:0001328)1.76040736
104Nephroblastoma (Wilms tumor) (HP:0002667)1.75420616
105Sloping forehead (HP:0000340)1.75390318
106Myokymia (HP:0002411)1.75344738
107Narrow forehead (HP:0000341)1.74986024
108Broad foot (HP:0001769)1.74825554
109Abnormal drinking behavior (HP:0030082)1.74283777
110Polydipsia (HP:0001959)1.74283777
111Cupped ear (HP:0000378)1.73938558
112Aplasia cutis congenita (HP:0001057)1.73574825
113Inappropriate behavior (HP:0000719)1.73541722
114Aqueductal stenosis (HP:0002410)1.72759326
115Progressive inability to walk (HP:0002505)1.72649626
116Vitreoretinal degeneration (HP:0000655)1.72201278
117Bifid tongue (HP:0010297)1.72069982
118Widely spaced teeth (HP:0000687)1.72020693
119Osteomalacia (HP:0002749)1.71237190
120Visual hallucinations (HP:0002367)1.71137210
121Hemiparesis (HP:0001269)1.70378491
122Truncal ataxia (HP:0002078)1.70264146
123Tented upper lip vermilion (HP:0010804)1.70242792
124Deeply set eye (HP:0000490)1.69619811
125Glioma (HP:0009733)1.69592436
126Decreased central vision (HP:0007663)1.69577027
127Patchy hypopigmentation of hair (HP:0011365)1.69099288
128Nephronophthisis (HP:0000090)1.67554115
129Embryonal renal neoplasm (HP:0011794)1.66309728
130Septo-optic dysplasia (HP:0100842)1.66123167
131Mesomelia (HP:0003027)1.64208342
132Genetic anticipation (HP:0003743)1.59675803
133Abnormality of midbrain morphology (HP:0002418)1.57093691
134Molar tooth sign on MRI (HP:0002419)1.57093691
135Gastroesophageal reflux (HP:0002020)1.56567860
136Optic nerve hypoplasia (HP:0000609)1.55510254
137Abnormality of the renal medulla (HP:0100957)1.54794400
138Congenital sensorineural hearing impairment (HP:0008527)1.54280693
139Cutaneous finger syndactyly (HP:0010554)1.53956308
140Abnormality of the parietal bone (HP:0002696)1.53690688
141Abnormality of the carotid arteries (HP:0005344)1.52550163
142Abnormal respiratory motile cilium physiology (HP:0012261)1.52459304
143Preaxial hand polydactyly (HP:0001177)1.52426821
144Impaired vibration sensation in the lower limbs (HP:0002166)1.52049208
145Medial flaring of the eyebrow (HP:0010747)1.49910169
146Hypothermia (HP:0002045)1.49886984
147Agammaglobulinemia (HP:0004432)1.49216786
148Heterochromia iridis (HP:0001100)1.48978673
149Muscle fiber atrophy (HP:0100295)1.48792584
150Impaired smooth pursuit (HP:0007772)1.48520148
151Astigmatism (HP:0000483)1.48268533
152Abnormality of the frontal sinuses (HP:0002687)1.47349463
153Abnormality of ocular smooth pursuit (HP:0000617)1.46676078
154Postaxial foot polydactyly (HP:0001830)1.46645488
155Abnormality of the fingertips (HP:0001211)1.46338468
156Abnormality of the columella (HP:0009929)1.46248139
157Chorioretinal coloboma (HP:0000567)1.46156636
158Median cleft lip (HP:0000161)1.45887908
159Abnormality of the incisor (HP:0000676)1.44471208

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.30182343
2EPHA43.54793297
3BCKDK3.54554383
4CASK3.35685260
5RIPK43.00469725
6MAP2K72.82087925
7TNIK2.70569496
8BMPR1B2.37057257
9MARK12.33916220
10BMPR22.16488358
11MAP4K22.05188081
12EIF2AK32.00921416
13MAP3K41.97666267
14ZAK1.92097577
15MAP3K131.90772262
16MAP3K141.85450650
17TXK1.73584142
18INSRR1.71061487
19PLK21.65839112
20SGK21.62454873
21MAP3K121.57513697
22MAPK131.52776526
23STK391.42578273
24YES11.37952908
25NTRK21.37909708
26SIK31.37363898
27ACVR1B1.36431850
28SIK21.35316992
29PRPF4B1.33892170
30DAPK21.31938141
31ADRBK21.29189182
32TRIM281.25772471
33EIF2AK21.24902804
34MKNK21.24529798
35CSNK1G21.23723914
36CDC42BPA1.23667650
37PNCK1.22816251
38CSNK1G11.21818415
39CSNK1A1L1.19983676
40WNK41.19856971
41AKT31.19817768
42CAMKK21.15700189
43DYRK21.14280834
44FRK1.13211931
45TAOK21.08603060
46CDC71.06992494
47SGK11.05423617
48CDK31.05065203
49MAP2K41.02234655
50MUSK1.01484809
51CSNK1G31.00915963
52FES0.97320848
53SGK30.96963614
54SGK2230.95614987
55SGK4940.95614987
56STK240.95564561
57GRK70.95183210
58CAMKK10.95036855
59BRD40.94532782
60CCNB10.93176750
61IRAK40.92785807
62TNK20.91966991
63NEK60.91238340
64MAP3K90.91225856
65TAOK30.90687047
66GRK50.89777826
67TGFBR10.88313107
68SRPK10.88168713
69MINK10.88066143
70PAK30.87374887
71LATS10.86482398
72PLK40.85739756
73VRK10.83050340
74FGR0.79594151
75CDK50.78941413
76NLK0.78607926
77DYRK1A0.77029009
78BCR0.76833882
79BRSK20.76449628
80CAMK2A0.75118905
81ERBB30.72588981
82NUAK10.72353683
83PRKCG0.72252301
84CLK10.71850385
85PINK10.70950211
86DAPK10.70829428
87PRKCE0.70158435
88TAF10.68419476
89WEE10.66826610
90STK110.66825678
91CAMK40.64824325
92CAMK10.64671867
93MAP2K60.63200320
94CDK80.61773846
95CAMK1G0.61526565
96STK380.61126260
97TEC0.61066642
98CSNK1D0.59146355
99FGFR20.58268775
100PTK2B0.56853372
101ADRBK10.55499740
102FLT30.55109390
103WNK10.54549879
104IRAK30.53831816
105CDK120.53755035
106FER0.53515390
107RPS6KA40.53196911
108CAMK1D0.53159586
109DYRK30.52325124
110CAMK2B0.52108861
111PDK10.51974181
112IKBKE0.51390244
113WNK30.50912445
114MAPKAPK50.50123277
115MKNK10.49641660
116PLK30.49199204
117TIE10.48500631
118SYK0.48109448
119KSR10.47895797
120OBSCN0.46960102
121PRKCH0.45870299
122CDK190.45438664
123CHEK20.44145668
124PAK60.43589537
125PLK10.42836199
126CSNK1A10.42165712
127TRPM70.41427949
128ATM0.40258033
129GRK10.39970651
130OXSR10.39499614
131ATR0.39005451
132PRKD20.38669690
133PRKD30.37792438
134PKN10.37749358
135STK30.36596849
136TLK10.35046766
137STK38L0.34687593
138FGFR10.33788895
139BUB10.33476114
140UHMK10.32752131

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.12389781
2Olfactory transduction_Homo sapiens_hsa047402.30955397
3Propanoate metabolism_Homo sapiens_hsa006402.27354541
4Morphine addiction_Homo sapiens_hsa050322.24361735
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.08912089
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06551815
7Circadian entrainment_Homo sapiens_hsa047132.05592631
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05328400
9Glutamatergic synapse_Homo sapiens_hsa047241.99057572
10Long-term potentiation_Homo sapiens_hsa047201.90994103
11Synaptic vesicle cycle_Homo sapiens_hsa047211.84106171
12Nitrogen metabolism_Homo sapiens_hsa009101.83645028
13Amphetamine addiction_Homo sapiens_hsa050311.82937704
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82053553
15Butanoate metabolism_Homo sapiens_hsa006501.81400427
16Non-homologous end-joining_Homo sapiens_hsa034501.73371985
17Homologous recombination_Homo sapiens_hsa034401.70537257
18GABAergic synapse_Homo sapiens_hsa047271.70382342
19Taste transduction_Homo sapiens_hsa047421.66875358
20Basal transcription factors_Homo sapiens_hsa030221.62442587
21Salivary secretion_Homo sapiens_hsa049701.58917765
22Serotonergic synapse_Homo sapiens_hsa047261.58469699
23Insulin secretion_Homo sapiens_hsa049111.55670830
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54902409
25Linoleic acid metabolism_Homo sapiens_hsa005911.48397361
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46690470
27Ether lipid metabolism_Homo sapiens_hsa005651.46052267
28Dopaminergic synapse_Homo sapiens_hsa047281.45575692
29Calcium signaling pathway_Homo sapiens_hsa040201.44824958
30Long-term depression_Homo sapiens_hsa047301.40890091
31RNA degradation_Homo sapiens_hsa030181.38070437
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37181960
33Cholinergic synapse_Homo sapiens_hsa047251.35606163
34Selenocompound metabolism_Homo sapiens_hsa004501.35324705
35Fanconi anemia pathway_Homo sapiens_hsa034601.33684541
36Renin secretion_Homo sapiens_hsa049241.33328928
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30392853
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22370507
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20773039
40Collecting duct acid secretion_Homo sapiens_hsa049661.18630819
41Protein export_Homo sapiens_hsa030601.18463249
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14728134
43Oxytocin signaling pathway_Homo sapiens_hsa049211.14209257
44Cocaine addiction_Homo sapiens_hsa050301.14066861
45cAMP signaling pathway_Homo sapiens_hsa040241.12199845
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10837965
47Hedgehog signaling pathway_Homo sapiens_hsa043401.09993929
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09149103
49Type I diabetes mellitus_Homo sapiens_hsa049401.08014744
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07196964
51Gastric acid secretion_Homo sapiens_hsa049711.06926820
52Phototransduction_Homo sapiens_hsa047441.06253193
53One carbon pool by folate_Homo sapiens_hsa006701.05249461
54GnRH signaling pathway_Homo sapiens_hsa049121.03865760
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01954183
56Axon guidance_Homo sapiens_hsa043600.97303134
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96532811
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.94790457
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94167837
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.94021600
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93606519
62Autoimmune thyroid disease_Homo sapiens_hsa053200.91356711
63Type II diabetes mellitus_Homo sapiens_hsa049300.90874231
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90377990
65Graft-versus-host disease_Homo sapiens_hsa053320.90193812
66ErbB signaling pathway_Homo sapiens_hsa040120.89379940
67Alcoholism_Homo sapiens_hsa050340.85130471
68Tryptophan metabolism_Homo sapiens_hsa003800.82936121
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82660355
70Chemokine signaling pathway_Homo sapiens_hsa040620.82269619
71Inositol phosphate metabolism_Homo sapiens_hsa005620.80724932
72Melanogenesis_Homo sapiens_hsa049160.80719025
73African trypanosomiasis_Homo sapiens_hsa051430.80435464
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80095149
75Retinol metabolism_Homo sapiens_hsa008300.79812304
76Dorso-ventral axis formation_Homo sapiens_hsa043200.79481262
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.79224504
78Rheumatoid arthritis_Homo sapiens_hsa053230.77963747
79Basal cell carcinoma_Homo sapiens_hsa052170.77907211
80ABC transporters_Homo sapiens_hsa020100.76736170
81MAPK signaling pathway_Homo sapiens_hsa040100.76591473
82Wnt signaling pathway_Homo sapiens_hsa043100.76505409
83Ras signaling pathway_Homo sapiens_hsa040140.75243556
84Caffeine metabolism_Homo sapiens_hsa002320.73999579
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73851311
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73542772
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73490620
88TGF-beta signaling pathway_Homo sapiens_hsa043500.73348524
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73161365
90Allograft rejection_Homo sapiens_hsa053300.73109182
91Glioma_Homo sapiens_hsa052140.72287524
92Hippo signaling pathway_Homo sapiens_hsa043900.71307207
93Pancreatic secretion_Homo sapiens_hsa049720.70448804
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70032617
95Choline metabolism in cancer_Homo sapiens_hsa052310.68876227
96Cardiac muscle contraction_Homo sapiens_hsa042600.68186845
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68004245
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.67248915
99RNA polymerase_Homo sapiens_hsa030200.66945100
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66936996
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66266563
102Rap1 signaling pathway_Homo sapiens_hsa040150.65554182
103Hematopoietic cell lineage_Homo sapiens_hsa046400.65171878
104Gap junction_Homo sapiens_hsa045400.63508152
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62709265
106Oocyte meiosis_Homo sapiens_hsa041140.62377034
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62109039
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.60914641
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60382617
110Sphingolipid metabolism_Homo sapiens_hsa006000.60307971
111Mismatch repair_Homo sapiens_hsa034300.60125208
112Tuberculosis_Homo sapiens_hsa051520.59659994
113TNF signaling pathway_Homo sapiens_hsa046680.59413550
114Primary immunodeficiency_Homo sapiens_hsa053400.59288208
115Regulation of autophagy_Homo sapiens_hsa041400.58891898
116Influenza A_Homo sapiens_hsa051640.58816242
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.58544278
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.58468648
119Cell cycle_Homo sapiens_hsa041100.58266227
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57946545
121Peroxisome_Homo sapiens_hsa041460.57915858
122Circadian rhythm_Homo sapiens_hsa047100.57214118
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56766218
124Estrogen signaling pathway_Homo sapiens_hsa049150.56263482
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55935795
126beta-Alanine metabolism_Homo sapiens_hsa004100.55734328
127T cell receptor signaling pathway_Homo sapiens_hsa046600.55647907
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55565583
129Ovarian steroidogenesis_Homo sapiens_hsa049130.53414265
130RNA transport_Homo sapiens_hsa030130.53284686
131Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53238707
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52055692
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.51574800
134Vibrio cholerae infection_Homo sapiens_hsa051100.51092494
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50737454
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50581830
137Osteoclast differentiation_Homo sapiens_hsa043800.50423563
138Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49823694
139Purine metabolism_Homo sapiens_hsa002300.47753191
140Measles_Homo sapiens_hsa051620.47263846
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46666698
142Platelet activation_Homo sapiens_hsa046110.46499268
143Lysine degradation_Homo sapiens_hsa003100.45883231
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45878726
145Melanoma_Homo sapiens_hsa052180.44695137
146Chemical carcinogenesis_Homo sapiens_hsa052040.44487068
147Herpes simplex infection_Homo sapiens_hsa051680.44201746
148Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43996135
149Base excision repair_Homo sapiens_hsa034100.43953922
150Salmonella infection_Homo sapiens_hsa051320.42312475
151Oxidative phosphorylation_Homo sapiens_hsa001900.41373518
152Steroid biosynthesis_Homo sapiens_hsa001000.41178119
153Primary bile acid biosynthesis_Homo sapiens_hsa001200.40009328
154Glycerolipid metabolism_Homo sapiens_hsa005610.39088527
155Vitamin B6 metabolism_Homo sapiens_hsa007500.38371862

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