HADH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene of this gene on chromosome 15. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.86019091
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.86019091
3L-phenylalanine metabolic process (GO:0006558)5.69547405
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.69547405
5negative regulation of gluconeogenesis (GO:0045721)5.35404502
6regulation of hexokinase activity (GO:1903299)5.15472939
7regulation of glucokinase activity (GO:0033131)5.15472939
8positive regulation of respiratory burst (GO:0060267)5.09135539
9lysine catabolic process (GO:0006554)4.93947948
10lysine metabolic process (GO:0006553)4.93947948
11Golgi transport vesicle coating (GO:0048200)4.87225448
12COPI coating of Golgi vesicle (GO:0048205)4.87225448
13lactate metabolic process (GO:0006089)4.85022975
14glyoxylate metabolic process (GO:0046487)4.81377338
15aromatic amino acid family catabolic process (GO:0009074)4.69159369
16regulation of type B pancreatic cell apoptotic process (GO:2000674)4.65144474
17* fatty acid beta-oxidation (GO:0006635)4.54716371
18alpha-linolenic acid metabolic process (GO:0036109)4.46431822
19tricarboxylic acid metabolic process (GO:0072350)4.41987974
20regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.31914512
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.24877650
22sulfur amino acid catabolic process (GO:0000098)4.24001563
23valine metabolic process (GO:0006573)4.23887196
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.23789637
25fructose metabolic process (GO:0006000)4.22966950
26* fatty acid oxidation (GO:0019395)4.21408237
27negative regulation of acute inflammatory response (GO:0002674)4.13293843
28* lipid oxidation (GO:0034440)4.11952084
29* fatty acid catabolic process (GO:0009062)4.10565005
30branched-chain amino acid catabolic process (GO:0009083)4.10452525
31short-chain fatty acid metabolic process (GO:0046459)4.08953737
32cysteine metabolic process (GO:0006534)4.06948376
33amino-acid betaine metabolic process (GO:0006577)3.99458453
34cellular ketone body metabolic process (GO:0046950)3.99097947
35branched-chain amino acid metabolic process (GO:0009081)3.98649208
36nitric oxide mediated signal transduction (GO:0007263)3.91545233
37regulation of triglyceride catabolic process (GO:0010896)3.88906824
38triglyceride homeostasis (GO:0070328)3.88203261
39acylglycerol homeostasis (GO:0055090)3.88203261
402-oxoglutarate metabolic process (GO:0006103)3.87149849
41drug transmembrane transport (GO:0006855)3.83919859
42COPII vesicle coating (GO:0048208)3.82704703
43endocrine pancreas development (GO:0031018)3.82394805
44acetyl-CoA metabolic process (GO:0006084)3.78658114
45* monocarboxylic acid catabolic process (GO:0072329)3.77973639
46biotin metabolic process (GO:0006768)3.76480893
47aspartate family amino acid catabolic process (GO:0009068)3.75550246
48bile acid biosynthetic process (GO:0006699)3.74095752
49homocysteine metabolic process (GO:0050667)3.73913145
50tryptophan metabolic process (GO:0006568)3.73095001
51oxaloacetate metabolic process (GO:0006107)3.69276497
52tricarboxylic acid cycle (GO:0006099)3.67569061
53indole-containing compound catabolic process (GO:0042436)3.66709274
54indolalkylamine catabolic process (GO:0046218)3.66709274
55tryptophan catabolic process (GO:0006569)3.66709274
56kynurenine metabolic process (GO:0070189)3.65989177
57fatty acid transmembrane transport (GO:1902001)3.65518936
58carnitine metabolic process (GO:0009437)3.61956842
59carnitine shuttle (GO:0006853)3.60751744
60tyrosine metabolic process (GO:0006570)3.56563416
61serine family amino acid catabolic process (GO:0009071)3.54978184
62intestinal cholesterol absorption (GO:0030299)3.54761187
63negative regulation of protein oligomerization (GO:0032460)3.53975732
64aromatic amino acid family metabolic process (GO:0009072)3.53445044
65high-density lipoprotein particle remodeling (GO:0034375)3.49297953
66alpha-amino acid catabolic process (GO:1901606)3.47756950
67ketone body metabolic process (GO:1902224)3.42738781
68* carboxylic acid catabolic process (GO:0046395)3.41995984
69* organic acid catabolic process (GO:0016054)3.41995984
70cellular amino acid catabolic process (GO:0009063)3.41770235
71regulation of cholesterol homeostasis (GO:2000188)3.40881580
72bile acid metabolic process (GO:0008206)3.40474621
73peptidyl-glutamic acid carboxylation (GO:0017187)3.40274928
74protein carboxylation (GO:0018214)3.40274928
75intestinal absorption (GO:0050892)3.38032560
76regulation of sequestering of triglyceride (GO:0010889)3.37988994
774-hydroxyproline metabolic process (GO:0019471)3.37329870
78positive regulation of fatty acid beta-oxidation (GO:0032000)3.35353278
79xenobiotic catabolic process (GO:0042178)3.34987614
80urea metabolic process (GO:0019627)3.32434213
81urea cycle (GO:0000050)3.32434213
82fatty acid homeostasis (GO:0055089)3.29760807
83regulation of cholesterol metabolic process (GO:0090181)3.29560873
84maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.29242363
85positive regulation of glycolytic process (GO:0045821)3.28510125
86plasma lipoprotein particle clearance (GO:0034381)3.28004994
87drug catabolic process (GO:0042737)3.23909943
88drug metabolic process (GO:0017144)3.23133073
89reverse cholesterol transport (GO:0043691)3.22870866
90gluconeogenesis (GO:0006094)3.21488209
91regulation of cholesterol esterification (GO:0010872)3.20234283
92negative regulation of hormone metabolic process (GO:0032351)3.19861563
93acyl-CoA biosynthetic process (GO:0071616)3.19649891
94thioester biosynthetic process (GO:0035384)3.19649891
95NADH metabolic process (GO:0006734)3.18000783
96negative regulation of glycogen metabolic process (GO:0070874)3.17927507
97nitrogen cycle metabolic process (GO:0071941)3.17253507
98succinate metabolic process (GO:0006105)3.16344109
99type B pancreatic cell development (GO:0003323)3.15932762
100glandular epithelial cell differentiation (GO:0002067)3.15398877
101cellular modified amino acid catabolic process (GO:0042219)3.14931892
102positive regulation of glycogen biosynthetic process (GO:0045725)3.14293644
103ethanol oxidation (GO:0006069)3.14025155
104positive regulation of fatty acid oxidation (GO:0046321)3.13621400
105phospholipid efflux (GO:0033700)3.12399696
106coenzyme A metabolic process (GO:0015936)3.11738314
107negative regulation of fibrinolysis (GO:0051918)3.07902746
108protein-lipid complex remodeling (GO:0034368)3.06779747
109macromolecular complex remodeling (GO:0034367)3.06779747
110plasma lipoprotein particle remodeling (GO:0034369)3.06779747
111coenzyme catabolic process (GO:0009109)3.04873301
112phospholipid homeostasis (GO:0055091)3.04836697
113drug transport (GO:0015893)3.04382647
114respiratory chain complex IV assembly (GO:0008535)3.03967458
115peptide hormone processing (GO:0016486)3.03378067
116positive regulation of triglyceride metabolic process (GO:0090208)3.03127915
117thioester metabolic process (GO:0035383)3.03021454
118acyl-CoA metabolic process (GO:0006637)3.03021454
119inositol phosphate catabolic process (GO:0071545)3.02731700
120urate metabolic process (GO:0046415)3.02729420
121mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.01913092
122regulation of fatty acid oxidation (GO:0046320)3.01893075
123water-soluble vitamin biosynthetic process (GO:0042364)3.01506666
124negative regulation of hormone biosynthetic process (GO:0032353)3.01276811
125positive regulation of peptide hormone secretion (GO:0090277)3.00650806
126peroxisome fission (GO:0016559)2.99748099
127mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.98268675
128detection of calcium ion (GO:0005513)2.95229163
129oxidative phosphorylation (GO:0006119)2.93111652
130nucleoside diphosphate catabolic process (GO:0009134)2.89357246
131positive regulation of insulin secretion (GO:0032024)2.87854358
132positive regulation of peptide secretion (GO:0002793)2.87436869
133inositol phosphate dephosphorylation (GO:0046855)2.86665969
134phosphorylated carbohydrate dephosphorylation (GO:0046838)2.86665969
135respiratory electron transport chain (GO:0022904)2.85924899
136phenylpropanoid metabolic process (GO:0009698)2.85338876
137hexose biosynthetic process (GO:0019319)2.85207183
138creatine metabolic process (GO:0006600)2.84006993
139positive regulation of glycogen metabolic process (GO:0070875)2.82347762
140regulation of glycolytic process (GO:0006110)2.82144435
141epoxygenase P450 pathway (GO:0019373)2.82139376
142electron transport chain (GO:0022900)2.80740681
143lipid particle organization (GO:0034389)2.78071166
144insulin secretion (GO:0030073)2.76898504
145transcytosis (GO:0045056)2.74080046
146positive regulation of insulin receptor signaling pathway (GO:0046628)2.73349183
147regulation of oxidative phosphorylation (GO:0002082)2.69707546
148regulation of respiratory burst (GO:0060263)2.66245262
149monosaccharide biosynthetic process (GO:0046364)2.66115450
150cytochrome complex assembly (GO:0017004)2.64243379
151glycogen catabolic process (GO:0005980)2.64159612
152aerobic respiration (GO:0009060)2.61443131
153glycogen biosynthetic process (GO:0005978)2.58717233
154glucan biosynthetic process (GO:0009250)2.58717233
155regulation of mitochondrial translation (GO:0070129)2.58508254
156glucan catabolic process (GO:0009251)2.56746162
157actin-myosin filament sliding (GO:0033275)2.55073732
158muscle filament sliding (GO:0030049)2.55073732
159positive regulation of protein autophosphorylation (GO:0031954)2.54940499
160response to hepatocyte growth factor (GO:0035728)2.54935450
161cellular response to hepatocyte growth factor stimulus (GO:0035729)2.54935450
162vitamin biosynthetic process (GO:0009110)2.53894931
163omega-hydroxylase P450 pathway (GO:0097267)2.53474936
164exocrine pancreas development (GO:0031017)2.51648096
165regulation of glucocorticoid metabolic process (GO:0031943)2.51294723
166aldehyde catabolic process (GO:0046185)2.49373437
167quinone biosynthetic process (GO:1901663)2.47913916

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.93762674
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.83133061
3* RXR_22158963_ChIP-Seq_LIVER_Mouse6.61137484
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.87239327
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.27743506
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.95556260
7EGR1_23403033_ChIP-Seq_LIVER_Mouse4.39315775
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.20252775
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.05898599
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.68378268
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.40948985
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.22316780
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.00540422
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.78876958
15CLOCK_20551151_ChIP-Seq_293T_Human2.58061343
16GATA1_22025678_ChIP-Seq_K562_Human2.52269103
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.43333062
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.20151924
19E2F7_22180533_ChIP-Seq_HELA_Human2.14582081
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.02493610
21* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.86479131
22RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.86204037
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77551228
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.69510872
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.64838537
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.62594939
27IGF1R_20145208_ChIP-Seq_DFB_Human1.61897771
28ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60787327
29TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.60360994
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55690029
31* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.55554560
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54420046
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51972642
34ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.51735522
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46771034
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46435139
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44321495
38EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.43311386
39DCP1A_22483619_ChIP-Seq_HELA_Human1.42403422
40DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.42222564
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36971276
42* VDR_23849224_ChIP-Seq_CD4+_Human1.33949912
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.33333835
44GATA4_25053715_ChIP-Seq_YYC3_Human1.29594428
45PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.29237953
46AR_21909140_ChIP-Seq_LNCAP_Human1.28929377
47TTF2_22483619_ChIP-Seq_HELA_Human1.28863345
48MYC_18940864_ChIP-ChIP_HL60_Human1.27896622
49ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26825041
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26645734
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.23401805
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23323522
53ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22700703
54HNF4A_19822575_ChIP-Seq_HepG2_Human1.22232134
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.21760745
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21610036
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20699627
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20461094
59CBP_21632823_ChIP-Seq_H3396_Human1.19817103
60HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19466267
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19195799
62TFEB_21752829_ChIP-Seq_HELA_Human1.14254881
63MYC_19030024_ChIP-ChIP_MESCs_Mouse1.13716646
64ELK1_19687146_ChIP-ChIP_HELA_Human1.12263191
65FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.11971647
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.10928349
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10928349
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10389588
69AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.08033394
70FOXP3_21729870_ChIP-Seq_TREG_Human1.07319063
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05996184
72PHF8_20622853_ChIP-Seq_HELA_Human1.05566958
73GABP_19822575_ChIP-Seq_HepG2_Human1.05113171
74* TBX20_22328084_ChIP-Seq_HEART_Mouse1.04834154
75* TBX20_22080862_ChIP-Seq_HEART_Mouse1.04834154
76SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04423713
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03463403
78KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03014419
79CDX2_22108803_ChIP-Seq_LS180_Human0.99290215
80SALL1_21062744_ChIP-ChIP_HESCs_Human0.98599891
81KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98436135
82ZNF263_19887448_ChIP-Seq_K562_Human0.97539628
83KDM5A_27292631_Chip-Seq_BREAST_Human0.97435055
84TP63_17297297_ChIP-ChIP_HaCaT_Human0.97337521
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97290139
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97124967
87RBPJ_21746931_ChIP-Seq_IB4_Human0.94605337
88HNFA_21074721_ChIP-Seq_CACO-2_Human0.94464514
89ELF1_17652178_ChIP-ChIP_JURKAT_Human0.93943709
90CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92559972
91CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.91649391
92ERG_20517297_ChIP-Seq_VCAP_Human0.91084488
93YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90514697
94GATA6_25053715_ChIP-Seq_YYC3_Human0.90071835
95HTT_18923047_ChIP-ChIP_STHdh_Human0.89148972
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89146489
97FOXA1_25552417_ChIP-Seq_VCAP_Human0.87792263
98HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87365162
99* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86441685
100GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.86343548
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85297715
102FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.84664602
103SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84086873
104GATA1_19941826_ChIP-Seq_K562_Human0.83185844
105E2F4_17652178_ChIP-ChIP_JURKAT_Human0.82832264
106AR_20517297_ChIP-Seq_VCAP_Human0.82617409
107GATA3_24758297_ChIP-Seq_MCF-7_Human0.82396602
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.82388448
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82378180
110TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82277525
111NFYB_21822215_ChIP-Seq_K562_Human0.81380880
112FOXA1_21572438_ChIP-Seq_LNCaP_Human0.81116169
113GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.80998086
114PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80398887
115RXRA_24833708_ChIP-Seq_LIVER_Mouse0.79954216
116CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79920594
117SALL4_22934838_ChIP-ChIP_CD34+_Human0.79489899
118FUS_26573619_Chip-Seq_HEK293_Human0.79443839
119BCAT_22108803_ChIP-Seq_LS180_Human0.79437136
120ESR2_21235772_ChIP-Seq_MCF-7_Human0.79233871
121NANOG_19829295_ChIP-Seq_ESCs_Human0.78584945
122SOX2_19829295_ChIP-Seq_ESCs_Human0.78584945
123SRF_21415370_ChIP-Seq_HL-1_Mouse0.77483824
124RARA_24833708_ChIP-Seq_LIVER_Mouse0.76041053
125BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.75514191
126RARB_24833708_ChIP-Seq_LIVER_Mouse0.75151858
127PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.74947296
128FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.74523776
129SOX2_20726797_ChIP-Seq_SW620_Human0.74492708
130LXR_22292898_ChIP-Seq_THP-1_Human0.71766542
131RACK7_27058665_Chip-Seq_MCF-7_Human0.69917838
132EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.68724518
133NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.68546480
134FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.67576220
135FOXO3_23340844_ChIP-Seq_DLD1_Human0.67057034
136SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.66619799
137JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.66531453
138SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.66131236
139PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.65117169
140* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.64857265
141* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.63954041
142ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.63840565
143TBX5_21415370_ChIP-Seq_HL-1_Mouse0.63651684
144TET1_21451524_ChIP-Seq_MESCs_Mouse0.62671318
145ZFX_18555785_ChIP-Seq_MESCs_Mouse0.62389344
146PPAR_26484153_Chip-Seq_NCI-H1993_Human0.62109642
147PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.61934593
148SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.61863349
149GABP_17652178_ChIP-ChIP_JURKAT_Human0.60507647
150NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.59581682
151* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.58736658
152STAT3_1855785_ChIP-Seq_MESCs_Mouse0.58638165
153ATF3_27146783_Chip-Seq_COLON_Human0.57647721
154CREB1_15753290_ChIP-ChIP_HEK293T_Human0.57627553
155TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.56907577
156FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.56773177
157KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.56186776
158GATA4_21415370_ChIP-Seq_HL-1_Mouse0.55798540
159CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.55771127
160BCOR_27268052_Chip-Seq_Bcells_Human0.55542549
161CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.55294007
162TRIM28_21343339_ChIP-Seq_HEK293_Human0.54755238
163* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.54720739

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.15731574
2MP0005360_urolithiasis5.35342697
3MP0005365_abnormal_bile_salt4.66182720
4MP0005085_abnormal_gallbladder_physiolo4.44479508
5MP0003195_calcinosis3.90959505
6MP0003806_abnormal_nucleotide_metabolis3.45543450
7MP0008875_abnormal_xenobiotic_pharmacok3.37593340
8MP0004043_abnormal_pH_regulation3.28066654
9MP0003252_abnormal_bile_duct3.08468909
10MP0002837_dystrophic_cardiac_calcinosis3.00427866
11MP0010234_abnormal_vibrissa_follicle2.95956044
12MP0010329_abnormal_lipoprotein_level2.72831596
13MP0009840_abnormal_foam_cell2.67943908
14MP0005332_abnormal_amino_acid2.65261843
15MP0001666_abnormal_nutrient_absorption2.50190486
16MP0003123_paternal_imprinting2.44809964
17MP0003122_maternal_imprinting2.27393018
18MP0005670_abnormal_white_adipose2.26853849
19MP0003787_abnormal_imprinting2.25268735
20MP0003283_abnormal_digestive_organ2.23746148
21MP0002822_catalepsy2.22508816
22MP0002118_abnormal_lipid_homeostasis2.12706553
23MP0009643_abnormal_urine_homeostasis2.12228273
24MP0005083_abnormal_biliary_tract2.07170863
25MP0002877_abnormal_melanocyte_morpholog2.05171013
26MP0002693_abnormal_pancreas_physiology1.86826970
27MP0000609_abnormal_liver_physiology1.84800487
28MP0006036_abnormal_mitochondrial_physio1.83154289
29MP0004145_abnormal_muscle_electrophysio1.82453849
30* MP0002078_abnormal_glucose_homeostasis1.82183302
31MP0004019_abnormal_vitamin_homeostasis1.81733612
32MP0002138_abnormal_hepatobiliary_system1.81357802
33MP0003191_abnormal_cellular_cholesterol1.77621064
34MP0008877_abnormal_DNA_methylation1.75210143
35MP0005220_abnormal_exocrine_pancreas1.72255791
36MP0000751_myopathy1.70061018
37* MP0001944_abnormal_pancreas_morphology1.65791871
38MP0000013_abnormal_adipose_tissue1.60486011
39MP0005319_abnormal_enzyme/_coenzyme1.60224268
40MP0005666_abnormal_adipose_tissue1.59760962
41MP0004130_abnormal_muscle_cell1.58339808
42MP0009780_abnormal_chondrocyte_physiolo1.54955854
43MP0002163_abnormal_gland_morphology1.53894237
44MP0002638_abnormal_pupillary_reflex1.44278998
45MP0002909_abnormal_adrenal_gland1.43084834
46MP0005645_abnormal_hypothalamus_physiol1.40976394
47MP0001764_abnormal_homeostasis1.39981136
48MP0003868_abnormal_feces_composition1.39580560
49MP0005636_abnormal_mineral_homeostasis1.36705027
50MP0003186_abnormal_redox_activity1.36154883
51MP0000678_abnormal_parathyroid_gland1.33395273
52MP0003011_delayed_dark_adaptation1.32670766
53MP0002971_abnormal_brown_adipose1.31589582
54MP0005535_abnormal_body_temperature1.29921555
55MP0001756_abnormal_urination1.29505067
56MP0005584_abnormal_enzyme/coenzyme_acti1.29027351
57MP0001661_extended_life_span1.23322452
58MP0004264_abnormal_extraembryonic_tissu1.22599372
59MP0005375_adipose_tissue_phenotype1.22281149
60MP0003121_genomic_imprinting1.18016105
61MP0001727_abnormal_embryo_implantation1.17261437
62MP0005379_endocrine/exocrine_gland_phen1.15787569
63MP0004185_abnormal_adipocyte_glucose1.15165353
64MP0001765_abnormal_ion_homeostasis1.14993502
65MP0000003_abnormal_adipose_tissue1.13978526
66MP0002106_abnormal_muscle_physiology1.13057747
67MP0004147_increased_porphyrin_level1.11020684
68MP0002876_abnormal_thyroid_physiology1.06909470
69MP0005330_cardiomyopathy1.05158720
70MP0003953_abnormal_hormone_level1.04474610
71MP0005334_abnormal_fat_pad1.04292098
72MP0005058_abnormal_lysosome_morphology1.03778363
73MP0002090_abnormal_vision1.02600754
74MP0006072_abnormal_retinal_apoptosis1.00323211
75MP0005369_muscle_phenotype0.99569600
76MP0004036_abnormal_muscle_relaxation0.97235637
77MP0008775_abnormal_heart_ventricle0.96567706
78MP0005451_abnormal_body_composition0.96356157
79MP0009642_abnormal_blood_homeostasis0.95639725
80MP0005646_abnormal_pituitary_gland0.95533820
81MP0000230_abnormal_systemic_arterial0.95249869
82MP0000598_abnormal_liver_morphology0.94783173
83MP0005448_abnormal_energy_balance0.93934079
84MP0004084_abnormal_cardiac_muscle0.90920632
85MP0010386_abnormal_urinary_bladder0.90757418
86MP0003718_maternal_effect0.89785902
87MP0010352_gastrointestinal_tract_polyps0.89611691
88MP0000462_abnormal_digestive_system0.88436365
89MP0000747_muscle_weakness0.84797565
90MP0005408_hypopigmentation0.84454000
91MP0002928_abnormal_bile_duct0.84348616
92MP0002269_muscular_atrophy0.83789643
93MP0004510_myositis0.83366306
94MP0000759_abnormal_skeletal_muscle0.82593920
95MP0002938_white_spotting0.81394621
96MP0005367_renal/urinary_system_phenotyp0.81377287
97MP0000516_abnormal_urinary_system0.81377287
98MP0003646_muscle_fatigue0.80478368
99MP0008961_abnormal_basal_metabolism0.80423670
100MP0005266_abnormal_metabolism0.79543093
101MP0002970_abnormal_white_adipose0.77591708
102MP0003959_abnormal_lean_body0.77385946
103MP0001984_abnormal_olfaction0.76737772
104MP0002102_abnormal_ear_morphology0.75718639
105MP0005084_abnormal_gallbladder_morpholo0.75700837
106MP0009379_abnormal_foot_pigmentation0.73342531
107MP0003300_gastrointestinal_ulcer0.73139411
108MP0009697_abnormal_copulation0.68682558
109MP0004215_abnormal_myocardial_fiber0.68518078
110MP0002896_abnormal_bone_mineralization0.67684243
111MP0003183_abnormal_peptide_metabolism0.67302485
112MP0000749_muscle_degeneration0.67038757
113MP0009672_abnormal_birth_weight0.64710192
114MP0002136_abnormal_kidney_physiology0.64320671
115MP0003705_abnormal_hypodermis_morpholog0.63326651
116MP0002972_abnormal_cardiac_muscle0.62761632
117MP0005376_homeostasis/metabolism_phenot0.62473652
118MP0010368_abnormal_lymphatic_system0.61539575
119MP0006035_abnormal_mitochondrial_morpho0.59694512
120MP0009763_increased_sensitivity_to0.58792826
121MP0000639_abnormal_adrenal_gland0.55488183
122MP0001544_abnormal_cardiovascular_syste0.54301969
123MP0005385_cardiovascular_system_phenoty0.54301969
124MP0000613_abnormal_salivary_gland0.54049768
125MP0003221_abnormal_cardiomyocyte_apopto0.53705133
126MP0000538_abnormal_urinary_bladder0.53049378
127MP0006138_congestive_heart_failure0.52190674
128MP0004087_abnormal_muscle_fiber0.51960684
129MP0005452_abnormal_adipose_tissue0.51901447
130MP0008469_abnormal_protein_level0.51182761
131MP0004782_abnormal_surfactant_physiolog0.48398007
132MP0005620_abnormal_muscle_contractility0.48350356

Predicted human phenotypes

RankGene SetZ-score
1* Hypoglycemic coma (HP:0001325)5.98837850
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.49749742
3Ketoacidosis (HP:0001993)5.36533420
4Generalized aminoaciduria (HP:0002909)5.24480096
5Ketosis (HP:0001946)4.97571111
6Intrahepatic cholestasis (HP:0001406)4.58832820
7Hyperglycinuria (HP:0003108)4.56235511
8Xanthomatosis (HP:0000991)4.29604115
9Prominent metopic ridge (HP:0005487)4.26611664
10Abnormality of fatty-acid metabolism (HP:0004359)4.26381607
11* Hyperinsulinemic hypoglycemia (HP:0000825)4.13453411
12Abnormality of glycine metabolism (HP:0010895)4.06065554
13Abnormality of serine family amino acid metabolism (HP:0010894)4.06065554
14Hyperammonemia (HP:0001987)3.94746347
15Abnormality of monocarboxylic acid metabolism (HP:0010996)3.92261706
16Abnormality of the metopic suture (HP:0005556)3.79750856
17Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.76412771
18Late onset (HP:0003584)3.73819736
19Hyperglycemia (HP:0003074)3.72683319
20* Hypoglycemic seizures (HP:0002173)3.67643706
21Hyperglycinemia (HP:0002154)3.65091746
22Hypobetalipoproteinemia (HP:0003563)3.57234966
23Prolonged partial thromboplastin time (HP:0003645)3.53479278
24Gout (HP:0001997)3.51875382
25* Abnormality of dicarboxylic acid metabolism (HP:0010995)3.51484025
26* Dicarboxylic aciduria (HP:0003215)3.51484025
27Deep venous thrombosis (HP:0002625)3.43881552
28Abnormality of the intrinsic pathway (HP:0010989)3.43037660
29Hypomagnesemia (HP:0002917)3.35465038
30Abnormality of purine metabolism (HP:0004352)3.28707292
31* Symptomatic seizures (HP:0011145)3.27613001
32Exercise-induced myalgia (HP:0003738)3.21993200
33Abnormality of glutamine family amino acid metabolism (HP:0010902)3.21191982
34Glycosuria (HP:0003076)3.20843943
35Abnormality of urine glucose concentration (HP:0011016)3.20843943
36Insulin-resistant diabetes mellitus (HP:0000831)3.20530527
37Hyperlipoproteinemia (HP:0010980)3.18186282
38Abnormality of endocrine pancreas physiology (HP:0012093)3.13660578
39Abnormality of the pancreatic islet cells (HP:0006476)3.13660578
40Pancreatic islet-cell hyperplasia (HP:0004510)3.12150708
41Abnormality of magnesium homeostasis (HP:0004921)3.10227230
42Proximal tubulopathy (HP:0000114)3.04992605
43Hypolipoproteinemia (HP:0010981)3.04353807
44Conjugated hyperbilirubinemia (HP:0002908)3.04311198
45Abnormality of the common coagulation pathway (HP:0010990)3.03133297
46Metabolic acidosis (HP:0001942)2.97422162
47Hypoalphalipoproteinemia (HP:0003233)2.85846529
48Calf muscle hypertrophy (HP:0008981)2.85835423
49Muscle hypertrophy of the lower extremities (HP:0008968)2.85528129
50Epidermoid cyst (HP:0200040)2.85241706
51Lethargy (HP:0001254)2.80838819
52Cerebral edema (HP:0002181)2.79602260
53Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.79223359
54Nemaline bodies (HP:0003798)2.78772814
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.76656240
56Increased circulating renin level (HP:0000848)2.72347366
57Hyperphosphatemia (HP:0002905)2.72251742
58Abnormality of nucleobase metabolism (HP:0010932)2.71252513
59Fat malabsorption (HP:0002630)2.71077198
60Insulin resistance (HP:0000855)2.69841993
61Muscle fiber inclusion bodies (HP:0100299)2.68486562
62* Myoglobinuria (HP:0002913)2.64405148
63EEG with generalized epileptiform discharges (HP:0011198)2.60943272
64Skin nodule (HP:0200036)2.59737663
65Abnormality of sulfur amino acid metabolism (HP:0004339)2.58839338
66Progressive macrocephaly (HP:0004481)2.57996934
67Increased serum pyruvate (HP:0003542)2.56580146
68Hypsarrhythmia (HP:0002521)2.55477192
69Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.54588085
70Hyperbilirubinemia (HP:0002904)2.52818934
71Epileptiform EEG discharges (HP:0011182)2.52784333
72Acute necrotizing encephalopathy (HP:0006965)2.52491156
73Renal cortical cysts (HP:0000803)2.51794668
74* Hepatic necrosis (HP:0002605)2.51292219
75Abnormality of glycolysis (HP:0004366)2.47300586
76Enlarged penis (HP:0000040)2.47269066
77Large for gestational age (HP:0001520)2.45762696
78Increased purine levels (HP:0004368)2.45547725
79Hyperuricemia (HP:0002149)2.45547725
80Hepatocellular necrosis (HP:0001404)2.42836708
81Vomiting (HP:0002013)2.41228498
82Acute encephalopathy (HP:0006846)2.41227630
83Methylmalonic acidemia (HP:0002912)2.40839671
84Abnormality of serum amino acid levels (HP:0003112)2.39745609
85Irritability (HP:0000737)2.39622819
86Hypothermia (HP:0002045)2.39383133
87Exercise-induced muscle cramps (HP:0003710)2.37405526
88Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.36575419
89Rhabdomyolysis (HP:0003201)2.35990653
90Complement deficiency (HP:0004431)2.34803223
91Mitochondrial inheritance (HP:0001427)2.30054653
92Increased muscle lipid content (HP:0009058)2.29720478
93Abnormality of methionine metabolism (HP:0010901)2.28345666
94Pancreatitis (HP:0001733)2.27886254
95EMG: myopathic abnormalities (HP:0003458)2.26878399
96Nausea (HP:0002018)2.26546799
97Abnormality of the vitamin B12 metabolism (HP:0004341)2.26397530
98Joint hemorrhage (HP:0005261)2.26073688
99Abnormality of proline metabolism (HP:0010907)2.24674739
100Hydroxyprolinuria (HP:0003080)2.24674739
101Hyperactive renin-angiotensin system (HP:0000841)2.23828548
102Delayed CNS myelination (HP:0002188)2.23412939
103Abnormality of vitamin B metabolism (HP:0004340)2.22549908
104Hyperphosphaturia (HP:0003109)2.22526331
105Limb hypertonia (HP:0002509)2.21986939
106Increased CSF lactate (HP:0002490)2.21771915
107Bundle branch block (HP:0011710)2.19468379
108Abnormal pancreas size (HP:0012094)2.18995430
109Palpitations (HP:0001962)2.17668607
110Alkalosis (HP:0001948)2.16434328
111Megaloblastic anemia (HP:0001889)2.14114953
112Type I diabetes mellitus (HP:0100651)2.13529205
113Methylmalonic aciduria (HP:0012120)2.10205037
114Hypokalemia (HP:0002900)2.09356455
115Abnormal enzyme/coenzyme activity (HP:0012379)2.05939002
116Rimmed vacuoles (HP:0003805)2.05484391
117Neoplasm of the adrenal gland (HP:0100631)2.05004364
118Abnormal cartilage morphology (HP:0002763)2.04894678
119Abnormality of the calf musculature (HP:0001430)2.02499125
120Hypokalemic alkalosis (HP:0001949)2.01767595
121Hypokinesia (HP:0002375)2.01753401
122Decreased activity of mitochondrial respiratory chain (HP:0008972)2.01668021
123Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.01668021
124Brushfield spots (HP:0001088)2.01474751
125Enlarged kidneys (HP:0000105)2.01364043
126Decreased circulating renin level (HP:0003351)2.00566887
127Abnormality of vitamin metabolism (HP:0100508)1.99775515
128Respiratory failure (HP:0002878)1.98533285
129Increased intramyocellular lipid droplets (HP:0012240)1.98160184
130Exercise intolerance (HP:0003546)1.97576160
131Hypercholesterolemia (HP:0003124)1.97108885
132Abnormal gallbladder morphology (HP:0012437)1.96243752
133Hyperthyroidism (HP:0000836)1.95702462
134Villous atrophy (HP:0011473)1.94914577
135Abnormality of small intestinal villus morphology (HP:0011472)1.94914577
136Sudden death (HP:0001699)1.94895618
137Abnormality of alkaline phosphatase activity (HP:0004379)1.94116397
138Abnormal mitochondria in muscle tissue (HP:0008316)1.93979642
139Protuberant abdomen (HP:0001538)1.93633915
140Muscular hypotonia of the trunk (HP:0008936)1.93539259
141Mucopolysacchariduria (HP:0008155)1.92926931
142Urinary glycosaminoglycan excretion (HP:0003541)1.92926931
143Conjunctival hamartoma (HP:0100780)1.91871860
144Steatorrhea (HP:0002570)1.90710587
145Elevated alkaline phosphatase (HP:0003155)1.90351936
146Abnormal urine phosphate concentration (HP:0012599)1.88952328
147Hypophosphatemia (HP:0002148)1.88660622
148Tongue fasciculations (HP:0001308)1.86835319
149Lipid accumulation in hepatocytes (HP:0006561)1.86291328
150Abnormality of renin-angiotensin system (HP:0000847)1.84222698
151Lactic acidosis (HP:0003128)1.84097618

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.44600318
2BCKDK5.92952496
3PASK3.99945920
4ERN13.47873670
5FGFR23.25493740
6FLT32.89505307
7MAPK152.85533586
8TRIB32.60502431
9WNK42.56647559
10MST42.54555519
11SIK12.47530819
12TAOK32.06357019
13ACVR1B2.03668042
14FGFR41.98767171
15VRK21.90954226
16PDK31.90929096
17PDK41.90929096
18FRK1.89840186
19TESK11.75881694
20IRAK31.73308099
21PRKD31.64227026
22MET1.60978779
23PKN21.56900281
24MAP3K21.49761188
25HIPK21.48131763
26BUB11.46789119
27PLK31.38509949
28MAP3K31.35232028
29PTK61.31186593
30TIE11.29614348
31MAP4K21.26651382
32TTK1.25543711
33ZAK1.22392145
34EIF2AK11.19296989
35OBSCN1.17870359
36FGFR31.17612343
37PDGFRA1.17555278
38STK241.15911635
39STK38L1.12932908
40MAP2K21.09606989
41PINK11.09519888
42STK31.09379975
43LATS11.08372757
44NUAK11.06733236
45PDK21.06279153
46BMPR1B1.04198299
47MST1R1.03559255
48VRK11.01934536
49TNIK1.01421026
50EPHB11.01339999
51LMTK20.98920950
52PTK20.98301015
53LIMK10.96412622
54PRKAA20.96117766
55IRAK10.95587384
56EPHA30.93529519
57DYRK1B0.91967593
58CSNK1G10.91015484
59WNK30.90476296
60PLK10.88894184
61CDC70.85682209
62MYLK0.82903732
63TTN0.82378385
64PRKAA10.82101331
65PIK3CG0.81196193
66NTRK30.80042573
67PLK40.79990458
68MAPK110.78809865
69MUSK0.77720717
70TRPM70.77123639
71PAK30.77075183
72MAP3K10.76531240
73CAMK1D0.75685919
74CSNK1G30.75623207
75EIF2AK30.74654396
76STK40.73307179
77NTRK10.71982858
78WEE10.71485586
79KDR0.69029807
80TSSK60.68199124
81BRSK20.67260745
82AKT30.65826089
83CDC42BPA0.64920108
84ERBB30.64701456
85DAPK20.64101472
86EPHA20.63631560
87JAK20.63606061
88GSK3A0.62877549
89DMPK0.62269702
90PNCK0.61914976
91GRK10.61771251
92PRKACG0.61229214
93IRAK20.59153657
94MAP2K60.58681641
95PRKD10.56844336
96NEK10.53814085
97STK390.53585185
98ATM0.51542389
99MAP2K30.51420502
100CSNK2A20.50870343
101PIM20.50620083
102SCYL20.50505884
103NEK90.49721091
104CDK30.48428600
105CSNK1G20.48037921
106CCNB10.47316136
107PBK0.45895653
108PRKCH0.45445332
109AURKB0.45357724
110PIK3CA0.44935489
111DAPK10.44526442
112ITK0.44299556
113CAMK10.44173366
114PHKG20.43920348
115PHKG10.43920348
116NLK0.43695166
117ABL20.43462315
118PRKCG0.43352598
119PRKG10.43251587
120MTOR0.42709410
121PRKG20.42444902
122ERBB40.42205441
123PRKD20.41070116
124CAMK2D0.40380796
125FER0.40116530
126CSNK2A10.39954104
127ATR0.38963228
128AKT20.37769124
129MAP2K10.36449248
130PDPK10.36345799
131MAP3K120.35194244
132STK160.34855807
133RIPK10.34360755
134DAPK30.33722669
135NME10.33038894
136OXSR10.32453561
137IGF1R0.32370594
138PRKDC0.31949385
139TRIM280.31679154
140MAP3K70.31611717
141TGFBR20.31210099
142MKNK10.30814151
143PRKCA0.30746644
144CSNK1A10.30621234
145PRKACA0.30178869
146JAK10.28049520
147PRKCI0.27202867
148ZAP700.27030650
149MAP3K100.26030882
150MAPKAPK30.25785772
151CAMK2G0.25717093
152TYK20.25307448
153PRKCE0.24532887
154NME20.24017214
155CSK0.23450696
156WNK10.21834383
157JAK30.21162536
158SGK2230.20235582
159SGK4940.20235582

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.23792202
2* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.09957688
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.95332781
4* Fatty acid degradation_Homo sapiens_hsa000712.90038322
5Propanoate metabolism_Homo sapiens_hsa006402.87389620
6Sulfur metabolism_Homo sapiens_hsa009202.75231239
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.64063717
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.57569420
9* Tryptophan metabolism_Homo sapiens_hsa003802.47692888
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.43150708
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.21967573
12* Fatty acid metabolism_Homo sapiens_hsa012122.20821789
13Nitrogen metabolism_Homo sapiens_hsa009102.19172807
14* Butanoate metabolism_Homo sapiens_hsa006502.16661301
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.10963392
16Peroxisome_Homo sapiens_hsa041462.03566421
17Protein export_Homo sapiens_hsa030601.97173660
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.97067076
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.93401785
20Selenocompound metabolism_Homo sapiens_hsa004501.92972203
21PPAR signaling pathway_Homo sapiens_hsa033201.86048960
22Pyruvate metabolism_Homo sapiens_hsa006201.81675781
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.79328471
24Arginine biosynthesis_Homo sapiens_hsa002201.73135559
25Histidine metabolism_Homo sapiens_hsa003401.73013517
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70177569
27beta-Alanine metabolism_Homo sapiens_hsa004101.69402087
28Folate biosynthesis_Homo sapiens_hsa007901.67681953
29Carbon metabolism_Homo sapiens_hsa012001.64731046
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.61368263
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58550827
32Fat digestion and absorption_Homo sapiens_hsa049751.53379227
33Starch and sucrose metabolism_Homo sapiens_hsa005001.53335759
34* Fatty acid elongation_Homo sapiens_hsa000621.53269562
35Phenylalanine metabolism_Homo sapiens_hsa003601.50418676
36Complement and coagulation cascades_Homo sapiens_hsa046101.27373483
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.27260181
38Tyrosine metabolism_Homo sapiens_hsa003501.26541186
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24391117
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.22131754
41Chemical carcinogenesis_Homo sapiens_hsa052041.17248982
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.12916896
43ABC transporters_Homo sapiens_hsa020101.10410710
44Arginine and proline metabolism_Homo sapiens_hsa003301.08420295
45Biosynthesis of amino acids_Homo sapiens_hsa012301.04863424
46Mismatch repair_Homo sapiens_hsa034301.03399011
47Retinol metabolism_Homo sapiens_hsa008301.03176736
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03134181
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03045532
50Proteasome_Homo sapiens_hsa030501.02243411
51Bile secretion_Homo sapiens_hsa049761.02018755
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00431960
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99970202
54Caffeine metabolism_Homo sapiens_hsa002320.99056035
55Cardiac muscle contraction_Homo sapiens_hsa042600.97405467
56DNA replication_Homo sapiens_hsa030300.95693246
57Galactose metabolism_Homo sapiens_hsa000520.95565539
58Vitamin digestion and absorption_Homo sapiens_hsa049770.85183756
59Glycerolipid metabolism_Homo sapiens_hsa005610.84339756
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.81708037
61Steroid biosynthesis_Homo sapiens_hsa001000.78001288
62* Lysine degradation_Homo sapiens_hsa003100.74946036
63Base excision repair_Homo sapiens_hsa034100.72307700
64Glutathione metabolism_Homo sapiens_hsa004800.70609412
65Insulin resistance_Homo sapiens_hsa049310.70291687
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68896798
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67303148
68Fructose and mannose metabolism_Homo sapiens_hsa000510.66316105
69Oxidative phosphorylation_Homo sapiens_hsa001900.65138487
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64274530
71Homologous recombination_Homo sapiens_hsa034400.63945646
72* Metabolic pathways_Homo sapiens_hsa011000.63286223
73Sulfur relay system_Homo sapiens_hsa041220.62200825
74Purine metabolism_Homo sapiens_hsa002300.61818568
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60962508
76Mineral absorption_Homo sapiens_hsa049780.59705827
77Collecting duct acid secretion_Homo sapiens_hsa049660.59351083
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58245650
79Pentose phosphate pathway_Homo sapiens_hsa000300.57759785
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57694213
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.55651963
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55476399
83Ovarian steroidogenesis_Homo sapiens_hsa049130.54464092
84Fatty acid biosynthesis_Homo sapiens_hsa000610.54123923
85Pyrimidine metabolism_Homo sapiens_hsa002400.53186522
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52365677
87Staphylococcus aureus infection_Homo sapiens_hsa051500.52262318
88Parkinsons disease_Homo sapiens_hsa050120.51560124
89Glucagon signaling pathway_Homo sapiens_hsa049220.49789680
90Linoleic acid metabolism_Homo sapiens_hsa005910.48406896
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48228940
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.46753616
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44961424
94Type II diabetes mellitus_Homo sapiens_hsa049300.43062079
95Circadian rhythm_Homo sapiens_hsa047100.42961053
96Type I diabetes mellitus_Homo sapiens_hsa049400.42935398
97Ribosome_Homo sapiens_hsa030100.39947276
98Insulin secretion_Homo sapiens_hsa049110.37793995
99Fanconi anemia pathway_Homo sapiens_hsa034600.36946227
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36389132
101Alzheimers disease_Homo sapiens_hsa050100.35443144
102Regulation of autophagy_Homo sapiens_hsa041400.34758516
103Non-homologous end-joining_Homo sapiens_hsa034500.34546485
104Renin secretion_Homo sapiens_hsa049240.34407582
105AMPK signaling pathway_Homo sapiens_hsa041520.33923233
106Vitamin B6 metabolism_Homo sapiens_hsa007500.33842447
107Lysosome_Homo sapiens_hsa041420.29907646
108Other glycan degradation_Homo sapiens_hsa005110.29551477
109N-Glycan biosynthesis_Homo sapiens_hsa005100.28635211
110One carbon pool by folate_Homo sapiens_hsa006700.28515513
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.28511490
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.21061418
113Insulin signaling pathway_Homo sapiens_hsa049100.19751624
114Renin-angiotensin system_Homo sapiens_hsa046140.16777048
115Protein digestion and absorption_Homo sapiens_hsa049740.16511828
116Huntingtons disease_Homo sapiens_hsa050160.14722681
117Vibrio cholerae infection_Homo sapiens_hsa051100.14700829
118Prion diseases_Homo sapiens_hsa050200.13095987
119Arachidonic acid metabolism_Homo sapiens_hsa005900.09546425

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