ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of glucokinase activity (GO:0033131)	4.46201124
2	regulation of hexokinase activity (GO:1903299)	4.46201124
3	L-phenylalanine catabolic process (GO:0006559)	4.41802112
4	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	4.41802112
5	nonmotile primary cilium assembly (GO:0035058)	4.36553553
6	brain morphogenesis (GO:0048854)	4.25387529
7	signal peptide processing (GO:0006465)	4.21947748
8	cellular ketone body metabolic process (GO:0046950)	4.21303256
9	COPII vesicle coating (GO:0048208)	3.88802638
10	ketone body metabolic process (GO:1902224)	3.69340187
11	L-phenylalanine metabolic process (GO:0006558)	3.60083604
12	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.60083604
13	aromatic amino acid family catabolic process (GO:0009074)	3.45711205
14	pancreas development (GO:0031016)	3.37781754
15	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	3.33953408
16	preassembly of GPI anchor in ER membrane (GO:0016254)	3.31989422
17	positive regulation of growth hormone secretion (GO:0060124)	3.26957180
18	retina layer formation (GO:0010842)	3.25876423
19	regulation of type B pancreatic cell apoptotic process (GO:2000674)	3.21649005
20	somite rostral/caudal axis specification (GO:0032525)	3.17935998
21	dopamine transport (GO:0015872)	3.16777746
22	platelet dense granule organization (GO:0060155)	3.14413199
23	endocrine pancreas development (GO:0031018)	3.14121280
24	C-terminal protein amino acid modification (GO:0018410)	3.14053695
25	magnesium ion transport (GO:0015693)	3.05646673
26	regulation of autophagic vacuole assembly (GO:2000785)	3.04196139
27	C-terminal protein lipidation (GO:0006501)	3.03821713
28	neuron fate determination (GO:0048664)	3.03637214
29	adaptation of signaling pathway (GO:0023058)	3.02112345
30	positive regulation of gluconeogenesis (GO:0045722)	2.98207998
31	regulation of cilium movement (GO:0003352)	2.97655450
32	indolalkylamine metabolic process (GO:0006586)	2.97468446
33	mannosylation (GO:0097502)	2.96065512
34	peptidyl-histidine modification (GO:0018202)	2.93581309
35	exocrine pancreas development (GO:0031017)	2.92172367
36	serotonin metabolic process (GO:0042428)	2.91455897
37	GPI anchor biosynthetic process (GO:0006506)	2.91213756
38	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.91185464
39	GPI anchor metabolic process (GO:0006505)	2.90557954
40	protein localization to cilium (GO:0061512)	2.89807425
41	toxin metabolic process (GO:0009404)	2.88531140
42	photoreceptor cell maintenance (GO:0045494)	2.86745271
43	tyrosine metabolic process (GO:0006570)	2.85643669
44	protein polyglutamylation (GO:0018095)	2.83942173
45	inositol phosphate catabolic process (GO:0071545)	2.81134231
46	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	2.80870951
47	insulin secretion (GO:0030073)	2.80766261
48	intraciliary transport (GO:0042073)	2.80568244
49	regulation of vacuole organization (GO:0044088)	2.78190286
50	protein localization to Golgi apparatus (GO:0034067)	2.77294529
51	Golgi to endosome transport (GO:0006895)	2.71541913
52	attachment of spindle microtubules to kinetochore (GO:0008608)	2.69008741
53	aromatic amino acid family metabolic process (GO:0009072)	2.66937993
54	ubiquinone metabolic process (GO:0006743)	2.64642292
55	nephron tubule morphogenesis (GO:0072078)	2.61949545
56	nephron epithelium morphogenesis (GO:0072088)	2.61949545
57	positive regulation of insulin secretion (GO:0032024)	2.61419675
58	protein complex biogenesis (GO:0070271)	2.60397796
59	indolalkylamine catabolic process (GO:0046218)	2.60297066
60	tryptophan catabolic process (GO:0006569)	2.60297066
61	indole-containing compound catabolic process (GO:0042436)	2.60297066
62	neural tube formation (GO:0001841)	2.59825955
63	cilium morphogenesis (GO:0060271)	2.58790426
64	indole-containing compound metabolic process (GO:0042430)	2.58763585
65	intra-Golgi vesicle-mediated transport (GO:0006891)	2.57207325
66	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.56991795
67	regulation of translation, ncRNA-mediated (GO:0045974)	2.56991795
68	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.56991795
69	primary amino compound metabolic process (GO:1901160)	2.56511486
70	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.56351142
71	NADH dehydrogenase complex assembly (GO:0010257)	2.56351142
72	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.56351142
73	L-fucose catabolic process (GO:0042355)	2.55195170
74	fucose catabolic process (GO:0019317)	2.55195170
75	L-fucose metabolic process (GO:0042354)	2.55195170
76	peptidyl-glutamic acid modification (GO:0018200)	2.51908342
77	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.51816061
78	negative regulation of execution phase of apoptosis (GO:1900118)	2.51391633
79	L-methionine salvage (GO:0071267)	2.50719852
80	L-methionine biosynthetic process (GO:0071265)	2.50719852
81	amino acid salvage (GO:0043102)	2.50719852
82	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.50513570
83	ubiquinone biosynthetic process (GO:0006744)	2.50018520
84	auditory behavior (GO:0031223)	2.49421343
85	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.48962308
86	inositol phosphate dephosphorylation (GO:0046855)	2.48962308
87	intracellular pH reduction (GO:0051452)	2.48276192
88	protein prenylation (GO:0018342)	2.48220936
89	prenylation (GO:0097354)	2.48220936
90	reflex (GO:0060004)	2.48144289
91	kynurenine metabolic process (GO:0070189)	2.45115336
92	dorsal/ventral neural tube patterning (GO:0021904)	2.44827644
93	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.44452543
94	mitochondrial respiratory chain complex assembly (GO:0033108)	2.39622028
95	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.39050516
96	microtubule anchoring (GO:0034453)	2.38214819
97	positive regulation of peptide hormone secretion (GO:0090277)	2.37879597
98	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.37538906
99	neurotransmitter uptake (GO:0001504)	2.36683784
100	catecholamine transport (GO:0051937)	2.36600957

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.74220721
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.27384159
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.16263759
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	3.08329540
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.97039081
6	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.59481837
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.56703273
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.52959418
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.32317036
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.25984717
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.19631862
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.13259671
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.12669153
14	FUS_26573619_Chip-Seq_HEK293_Human	1.98346169
15	P300_19829295_ChIP-Seq_ESCs_Human	1.98339485
16	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.97172280
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.95353273
18	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.90992727
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.87477304
20	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.86180194
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.84192723
22	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.82219968
23	EWS_26573619_Chip-Seq_HEK293_Human	1.82067323
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.80251150
25	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.74756108
26	VDR_22108803_ChIP-Seq_LS180_Human	1.72070783
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.71896154
28	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.71856665
29	EZH2_22144423_ChIP-Seq_EOC_Human	1.68309730
30	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.66573714
31	AR_25329375_ChIP-Seq_VCAP_Human	1.65820907
32	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.62330414
33	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.60831900
34	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.57444765
35	STAT3_23295773_ChIP-Seq_U87_Human	1.56647519
36	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.54719599
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.52101034
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.52101034
39	IGF1R_20145208_ChIP-Seq_DFB_Human	1.49299948
40	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.47221717
41	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.46589764
42	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.46063715
43	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.45332202
44	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.45021053
45	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.44762362
46	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.41880741
47	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.41434617
48	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.40747579
49	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.40423682
50	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.40153291
51	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.39906122
52	TP53_22573176_ChIP-Seq_HFKS_Human	1.38327506
53	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38269377
54	TCF4_23295773_ChIP-Seq_U87_Human	1.35103055
55	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.34527240
56	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.34190588
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34095342
58	P53_22387025_ChIP-Seq_ESCs_Mouse	1.32757886
59	BCAT_22108803_ChIP-Seq_LS180_Human	1.31588292
60	REST_21632747_ChIP-Seq_MESCs_Mouse	1.29049145
61	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.26864998
62	CDX2_22108803_ChIP-Seq_LS180_Human	1.25065089
63	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.24545108
64	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.24329181
65	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.22660358
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21665466
67	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21665466
68	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.20470148
69	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.19848877
70	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.19061987
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18192971
72	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17784859
73	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.17639001
74	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.17173239
75	TCF4_22108803_ChIP-Seq_LS180_Human	1.17018212
76	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.16621923
77	HTT_18923047_ChIP-ChIP_STHdh_Human	1.16388884
78	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.13195131
79	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12864052
80	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12466480
81	RNF2_27304074_Chip-Seq_NSC_Mouse	1.11307587
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.09813198
83	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.09593003
84	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.09546307
85	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.08836676
86	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.08836676
87	VDR_23849224_ChIP-Seq_CD4+_Human	1.06986010
88	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.06785206
89	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04416736
90	P300_18555785_Chip-Seq_ESCs_Mouse	1.03876089
91	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.02937946
92	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.02654804
93	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.01607248
94	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.01333547
95	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01083807
96	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.00903529
97	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99531403
98	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.98864829
99	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.98285936
100	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.98052295

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	3.96046355
2	MP0008057_abnormal_DNA_replication	3.52744592
3	MP0004270_analgesia	3.00286162
4	MP0002837_dystrophic_cardiac_calcinosis	2.79582524
5	MP0003880_abnormal_central_pattern	2.79116531
6	MP0000569_abnormal_digit_pigmentation	2.61678469
7	MP0005646_abnormal_pituitary_gland	2.61644993
8	MP0003787_abnormal_imprinting	2.55849232
9	MP0002009_preneoplasia	2.43154509
10	MP0006072_abnormal_retinal_apoptosis	2.31791724
11	MP0003122_maternal_imprinting	2.22440280
12	MP0005379_endocrine/exocrine_gland_phen	2.19837537
13	MP0003195_calcinosis	2.13342199
14	MP0008877_abnormal_DNA_methylation	2.12683504
15	MP0001501_abnormal_sleep_pattern	2.02129319
16	MP0002909_abnormal_adrenal_gland	1.98782776
17	MP0009046_muscle_twitch	1.98704794
18	MP0003890_abnormal_embryonic-extraembry	1.96700190
19	MP0010386_abnormal_urinary_bladder	1.94813569
20	MP0000631_abnormal_neuroendocrine_gland	1.90402588
21	MP0002638_abnormal_pupillary_reflex	1.86220224
22	MP0002254_reproductive_system_inflammat	1.83475722
23	MP0005645_abnormal_hypothalamus_physiol	1.82576739
24	MP0001944_abnormal_pancreas_morphology	1.71078256
25	MP0005551_abnormal_eye_electrophysiolog	1.67207953
26	MP0001529_abnormal_vocalization	1.65149480
27	MP0005423_abnormal_somatic_nervous	1.60501028
28	MP0002693_abnormal_pancreas_physiology	1.57505219
29	MP0004510_myositis	1.56776210
30	MP0002734_abnormal_mechanical_nocicepti	1.55677155
31	MP0005085_abnormal_gallbladder_physiolo	1.54451252
32	MP0005220_abnormal_exocrine_pancreas	1.54211202
33	MP0000013_abnormal_adipose_tissue	1.53656024
34	MP0005248_abnormal_Harderian_gland	1.50657812
35	MP0005253_abnormal_eye_physiology	1.50531977
36	MP0001984_abnormal_olfaction	1.41832676
37	MP0010329_abnormal_lipoprotein_level	1.41806179
38	MP0009780_abnormal_chondrocyte_physiolo	1.39394382
39	MP0002557_abnormal_social/conspecific_i	1.38004305
40	MP0004133_heterotaxia	1.34975990
41	MP0005187_abnormal_penis_morphology	1.33477238
42	MP0002139_abnormal_hepatobiliary_system	1.33370616
43	MP0002822_catalepsy	1.33314936
44	MP0009745_abnormal_behavioral_response	1.30277012
45	MP0005367_renal/urinary_system_phenotyp	1.30121537
46	MP0000516_abnormal_urinary_system	1.30121537
47	MP0002572_abnormal_emotion/affect_behav	1.27445457
48	MP0002078_abnormal_glucose_homeostasis	1.26886480
49	MP0004142_abnormal_muscle_tone	1.25916811
50	MP0002938_white_spotting	1.25711148
51	MP0002064_seizures	1.24984404
52	MP0002272_abnormal_nervous_system	1.24956554
53	MP0001905_abnormal_dopamine_level	1.24688549
54	MP0005448_abnormal_energy_balance	1.22746039
55	MP0002163_abnormal_gland_morphology	1.19979413
56	MP0005332_abnormal_amino_acid	1.19227230
57	MP0004924_abnormal_behavior	1.15681479
58	MP0005386_behavior/neurological_phenoty	1.15681479
59	MP0008872_abnormal_physiological_respon	1.14727084
60	MP0002090_abnormal_vision	1.14548629
61	MP0001486_abnormal_startle_reflex	1.11959616
62	MP0002736_abnormal_nociception_after	1.08324520
63	MP0003879_abnormal_hair_cell	1.06401691
64	MP0000427_abnormal_hair_cycle	1.05619813
65	MP0002733_abnormal_thermal_nociception	1.05560376
66	MP0000778_abnormal_nervous_system	1.02839420
67	MP0003635_abnormal_synaptic_transmissio	1.02478844
68	MP0001764_abnormal_homeostasis	1.02061996
69	MP0002876_abnormal_thyroid_physiology	1.01532689
70	MP0002067_abnormal_sensory_capabilities	1.01134587
71	MP0006276_abnormal_autonomic_nervous	1.00778264
72	MP0005266_abnormal_metabolism	0.99257780
73	MP0001968_abnormal_touch/_nociception	0.97692059
74	MP0004085_abnormal_heartbeat	0.95912707
75	MP0005084_abnormal_gallbladder_morpholo	0.95507184
76	MP0004043_abnormal_pH_regulation	0.94288518
77	MP0001756_abnormal_urination	0.94094144
78	MP0003121_genomic_imprinting	0.93474964
79	MP0002229_neurodegeneration	0.92950139
80	MP0002751_abnormal_autonomic_nervous	0.92124537
81	MP0000230_abnormal_systemic_arterial	0.90402794
82	MP0001970_abnormal_pain_threshold	0.90313833
83	MP0003633_abnormal_nervous_system	0.90050651
84	MP0002234_abnormal_pharynx_morphology	0.89019808
85	MP0002928_abnormal_bile_duct	0.87495316
86	MP0000647_abnormal_sebaceous_gland	0.87277876
87	MP0000639_abnormal_adrenal_gland	0.85750200
88	MP0008995_early_reproductive_senescence	0.84189947
89	MP0002069_abnormal_eating/drinking_beha	0.83995686
90	MP0004859_abnormal_synaptic_plasticity	0.83726497
91	MP0002063_abnormal_learning/memory/cond	0.83156779
92	MP0004215_abnormal_myocardial_fiber	0.80848871
93	MP0003953_abnormal_hormone_level	0.79748230
94	MP0002295_abnormal_pulmonary_circulatio	0.78612876
95	MP0002102_abnormal_ear_morphology	0.77585416
96	MP0002166_altered_tumor_susceptibility	0.77085913
97	MP0001664_abnormal_digestion	0.76190544
98	MP0008058_abnormal_DNA_repair	0.73933132
99	MP0003137_abnormal_impulse_conducting	0.73595045
100	MP0001986_abnormal_taste_sensitivity	0.73203795

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Medial flaring of the eyebrow (HP:0010747)	3.63711378
2	Gait imbalance (HP:0002141)	3.55694858
3	Congenital primary aphakia (HP:0007707)	3.50518382
4	Large for gestational age (HP:0001520)	3.45712066
5	Vacuolated lymphocytes (HP:0001922)	3.42362448
6	Hypothermia (HP:0002045)	3.34138744
7	Arthropathy (HP:0003040)	3.26536184
8	Pancreatic cysts (HP:0001737)	3.17266289
9	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.16234544
10	Nephrogenic diabetes insipidus (HP:0009806)	3.04191151
11	Prolonged partial thromboplastin time (HP:0003645)	2.98937000
12	Chronic hepatic failure (HP:0100626)	2.97342523
13	Vascular calcification (HP:0004934)	2.96906115
14	Hyperventilation (HP:0002883)	2.92782761
15	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.91834730
16	Abnormal protein N-linked glycosylation (HP:0012347)	2.91834730
17	Abnormal protein glycosylation (HP:0012346)	2.91834730
18	Abnormal glycosylation (HP:0012345)	2.91834730
19	Molar tooth sign on MRI (HP:0002419)	2.86837653
20	Abnormality of midbrain morphology (HP:0002418)	2.86837653
21	Limb dystonia (HP:0002451)	2.84085159
22	Pancreatic fibrosis (HP:0100732)	2.83103952
23	True hermaphroditism (HP:0010459)	2.79519264
24	Renal cortical cysts (HP:0000803)	2.77860470
25	Abnormality of the renal cortex (HP:0011035)	2.74792783
26	Mitral stenosis (HP:0001718)	2.67673300
27	Tubulointerstitial nephritis (HP:0001970)	2.66082020
28	Acute necrotizing encephalopathy (HP:0006965)	2.64073414
29	Progressive macrocephaly (HP:0004481)	2.62341126
30	Vaginal atresia (HP:0000148)	2.50751154
31	Ketoacidosis (HP:0001993)	2.49046949
32	Agitation (HP:0000713)	2.48722087
33	Progressive cerebellar ataxia (HP:0002073)	2.47473665
34	Genital tract atresia (HP:0001827)	2.46184879
35	Cardiovascular calcification (HP:0011915)	2.45919736
36	Hemiparesis (HP:0001269)	2.45803811
37	Poor coordination (HP:0002370)	2.45239950
38	Intestinal atresia (HP:0011100)	2.43979921
39	Abnormality of alanine metabolism (HP:0010916)	2.43075134
40	Hyperalaninemia (HP:0003348)	2.43075134
41	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.43075134
42	Broad-based gait (HP:0002136)	2.37438617
43	Gaze-evoked nystagmus (HP:0000640)	2.35922375
44	Papillary thyroid carcinoma (HP:0002895)	2.35041168
45	EEG with generalized epileptiform discharges (HP:0011198)	2.34926343
46	Type II lissencephaly (HP:0007260)	2.34727023
47	Epileptiform EEG discharges (HP:0011182)	2.34457960
48	Attenuation of retinal blood vessels (HP:0007843)	2.33047403
49	Hypsarrhythmia (HP:0002521)	2.31584418
50	Nephronophthisis (HP:0000090)	2.26566010
51	Methylmalonic acidemia (HP:0002912)	2.25130774
52	Constricted visual fields (HP:0001133)	2.23861035
53	Thyroid carcinoma (HP:0002890)	2.22478131
54	Abnormality of vitamin B metabolism (HP:0004340)	2.20237156
55	Optic nerve hypoplasia (HP:0000609)	2.20149954
56	Inability to walk (HP:0002540)	2.17064940
57	Abnormality of the renal medulla (HP:0100957)	2.15903285
58	Polyphagia (HP:0002591)	2.14538823
59	Acute encephalopathy (HP:0006846)	2.13905583
60	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.11453947
61	Abnormality of the labia minora (HP:0012880)	2.07294664
62	Thyroid-stimulating hormone excess (HP:0002925)	2.04002538
63	Type I transferrin isoform profile (HP:0003642)	2.03091402
64	Left ventricular hypertrophy (HP:0001712)	2.00056617
65	Abnormal mitochondria in muscle tissue (HP:0008316)	1.98367265
66	Short chin (HP:0000331)	1.97223287
67	Hyperinsulinemic hypoglycemia (HP:0000825)	1.96564022
68	Methylmalonic aciduria (HP:0012120)	1.96057236
69	Abnormal drinking behavior (HP:0030082)	1.94488692
70	Polydipsia (HP:0001959)	1.94488692
71	Amelogenesis imperfecta (HP:0000705)	1.92670486
72	Furrowed tongue (HP:0000221)	1.92614196
73	Congenital sensorineural hearing impairment (HP:0008527)	1.91237249
74	Genetic anticipation (HP:0003743)	1.90234112
75	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.90133720
76	Abnormality of dental color (HP:0011073)	1.89114432
77	Tongue fasciculations (HP:0001308)	1.88409676
78	Diminished movement (HP:0002374)	1.88320311
79	Cystic liver disease (HP:0006706)	1.87916809
80	Neuroendocrine neoplasm (HP:0100634)	1.86986736
81	Increased CSF lactate (HP:0002490)	1.85813673
82	Pancreatic islet-cell hyperplasia (HP:0004510)	1.85710172
83	Neoplasm of the adrenal cortex (HP:0100641)	1.84157737
84	Hypokinesia (HP:0002375)	1.84140127
85	Mitochondrial inheritance (HP:0001427)	1.83434083
86	Cerebellar dysplasia (HP:0007033)	1.82932459
87	Postural tremor (HP:0002174)	1.80415059
88	Volvulus (HP:0002580)	1.80178641
89	Bile duct proliferation (HP:0001408)	1.80104117
90	Abnormal biliary tract physiology (HP:0012439)	1.80104117
91	Central scotoma (HP:0000603)	1.79267533
92	Congenital malformation of the right heart (HP:0011723)	1.77374428
93	Double outlet right ventricle (HP:0001719)	1.77374428
94	Type I diabetes mellitus (HP:0100651)	1.76407155
95	Abnormal eating behavior (HP:0100738)	1.76284208
96	Generalized myoclonic seizures (HP:0002123)	1.75804324
97	Lissencephaly (HP:0001339)	1.75801092
98	Abdominal situs inversus (HP:0003363)	1.75589914
99	Abnormality of abdominal situs (HP:0011620)	1.75589914
100	Broad foot (HP:0001769)	1.75236707

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.42436088
2	MAP4K2	4.28405274
3	EPHA4	3.48197325
4	ACVR1B	2.88358380
5	EIF2AK3	2.67897780
6	WNK3	2.36908129
7	BMPR1B	2.27976836
8	PHKG1	2.24825781
9	PHKG2	2.24825781
10	MAP3K4	2.20350933
11	CSNK1G1	2.01489284
12	SRPK1	1.91687156
13	AKT3	1.84695178
14	CASK	1.80832611
15	CSNK1G3	1.80331431
16	MST4	1.77296747
17	MKNK2	1.71523797
18	NTRK3	1.66735592
19	CSNK1G2	1.58245944
20	ERBB3	1.57566205
21	EPHA3	1.54073850
22	ZAK	1.52279105
23	TNIK	1.46778859
24	CSNK1A1L	1.45058123
25	MAPK13	1.38887746
26	PNCK	1.37436123
27	GRK1	1.36034096
28	MARK1	1.34199882
29	NLK	1.27287262
30	MAPKAPK3	1.26446228
31	TSSK6	1.18680887
32	DAPK2	1.15042890
33	PIM2	1.13155615
34	FGFR2	1.10708759
35	MAPK15	1.10390608
36	MAP3K12	1.07172434
37	TRPM7	1.07067908
38	INSRR	1.04746412
39	STK38L	1.04123146
40	EIF2AK1	1.01576750
41	VRK1	0.99598134
42	BRSK2	0.99005052
43	TLK1	0.97802872
44	BRD4	0.94416432
45	ADRBK2	0.94279295
46	EIF2AK2	0.93336802
47	OXSR1	0.91114250
48	PAK3	0.90064950
49	SGK2	0.89941278
50	TGFBR1	0.88658922
51	PINK1	0.85497482
52	CAMKK2	0.82113657
53	WEE1	0.80073709
54	PRKCE	0.79815672
55	OBSCN	0.78354032
56	STK39	0.78311214
57	NUAK1	0.77038030
58	CCNB1	0.74771262
59	PRKCG	0.72969997
60	MKNK1	0.72011416
61	PIM1	0.70408771
62	CSNK1A1	0.68512275
63	PDK2	0.60847092
64	IRAK2	0.58871884
65	TRIM28	0.56825534
66	SGK494	0.56324664
67	SGK223	0.56324664
68	MAP2K7	0.56036319
69	UHMK1	0.54942071
70	CSNK1D	0.51598250
71	DAPK3	0.51388323
72	CHUK	0.47223277
73	PRKG1	0.46609870
74	YES1	0.45375114
75	CAMK1G	0.45301040
76	EEF2K	0.44807521
77	PLK3	0.44051912
78	ADRBK1	0.42147848
79	BCR	0.41864620
80	PASK	0.40036288
81	DYRK1B	0.39050485
82	PRKAA2	0.38533395
83	MAP3K2	0.37384113
84	MAPKAPK5	0.37359495
85	SGK3	0.35740257
86	TAOK1	0.35364754
87	PLK2	0.35165071
88	CAMK2A	0.35094437
89	PRKAA1	0.34920735
90	CAMK1D	0.33819049
91	ATM	0.32625666
92	SIK2	0.31658568
93	FGFR3	0.31337952
94	CSNK1E	0.30603928
95	MYLK	0.28294140
96	PRKACA	0.26858997
97	CDK6	0.26040245
98	IKBKE	0.25157090
99	RPS6KA3	0.24974867
100	PRKCB	0.24819240

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.89173162
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.56303521
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.96776633
4	Selenocompound metabolism_Homo sapiens_hsa00450	2.93301648
5	Butanoate metabolism_Homo sapiens_hsa00650	2.83294222
6	Steroid biosynthesis_Homo sapiens_hsa00100	2.61980193
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.54227587
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.52007850
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.43326634
10	Sulfur metabolism_Homo sapiens_hsa00920	2.31643526
11	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.94388796
12	Collecting duct acid secretion_Homo sapiens_hsa04966	1.91988928
13	Folate biosynthesis_Homo sapiens_hsa00790	1.78417414
14	Insulin secretion_Homo sapiens_hsa04911	1.76360856
15	Propanoate metabolism_Homo sapiens_hsa00640	1.76135466
16	Parkinsons disease_Homo sapiens_hsa05012	1.70947610
17	Circadian rhythm_Homo sapiens_hsa04710	1.63789226
18	Nicotine addiction_Homo sapiens_hsa05033	1.49560965
19	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.46663010
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.45205408
21	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.36095178
22	GABAergic synapse_Homo sapiens_hsa04727	1.33379388
23	Alzheimers disease_Homo sapiens_hsa05010	1.23536432
24	Phototransduction_Homo sapiens_hsa04744	1.22788647
25	Taste transduction_Homo sapiens_hsa04742	1.21807301
26	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.21043332
27	Circadian entrainment_Homo sapiens_hsa04713	1.20699199
28	Dopaminergic synapse_Homo sapiens_hsa04728	1.20635094
29	Peroxisome_Homo sapiens_hsa04146	1.20085082
30	Amphetamine addiction_Homo sapiens_hsa05031	1.18883488
31	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.16212490
32	Regulation of autophagy_Homo sapiens_hsa04140	1.15883352
33	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.15742236
34	Cocaine addiction_Homo sapiens_hsa05030	1.15652129
35	Vibrio cholerae infection_Homo sapiens_hsa05110	1.09622159
36	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.07649883
37	ABC transporters_Homo sapiens_hsa02010	1.06721766
38	Basal transcription factors_Homo sapiens_hsa03022	1.05469990
39	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.05384568
40	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.02870246
41	Huntingtons disease_Homo sapiens_hsa05016	1.02428640
42	Renin secretion_Homo sapiens_hsa04924	0.98532751
43	Serotonergic synapse_Homo sapiens_hsa04726	0.97550858
44	Sphingolipid metabolism_Homo sapiens_hsa00600	0.97535357
45	Ether lipid metabolism_Homo sapiens_hsa00565	0.96082448
46	Salivary secretion_Homo sapiens_hsa04970	0.95726130
47	Fatty acid elongation_Homo sapiens_hsa00062	0.95663101
48	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.94825177
49	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.94548089
50	Fanconi anemia pathway_Homo sapiens_hsa03460	0.94321787
51	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.93108835
52	Cardiac muscle contraction_Homo sapiens_hsa04260	0.92075427
53	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.90569280
54	Morphine addiction_Homo sapiens_hsa05032	0.90320649
55	Olfactory transduction_Homo sapiens_hsa04740	0.89139857
56	Nitrogen metabolism_Homo sapiens_hsa00910	0.87650030
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.86875070
58	Fatty acid metabolism_Homo sapiens_hsa01212	0.86831915
59	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.83691457
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.81930134
61	Glutamatergic synapse_Homo sapiens_hsa04724	0.77739524
62	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.74785968
63	RNA polymerase_Homo sapiens_hsa03020	0.72322963
64	Histidine metabolism_Homo sapiens_hsa00340	0.70301893
65	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.69693899
66	Mineral absorption_Homo sapiens_hsa04978	0.67891749
67	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.67573811
68	Metabolic pathways_Homo sapiens_hsa01100	0.67305431
69	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.65957059
70	Linoleic acid metabolism_Homo sapiens_hsa00591	0.64150243
71	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.61574812
72	RNA degradation_Homo sapiens_hsa03018	0.59423087
73	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.58198123
74	Long-term depression_Homo sapiens_hsa04730	0.55573431
75	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.54053822
76	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.53675636
77	cAMP signaling pathway_Homo sapiens_hsa04024	0.52871827
78	Chemical carcinogenesis_Homo sapiens_hsa05204	0.51923444
79	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.49037554
80	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.46613195
81	One carbon pool by folate_Homo sapiens_hsa00670	0.46255927
82	Other glycan degradation_Homo sapiens_hsa00511	0.45600031
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44982411
84	Purine metabolism_Homo sapiens_hsa00230	0.44880060
85	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.44849495
86	Tyrosine metabolism_Homo sapiens_hsa00350	0.44512838
87	Oocyte meiosis_Homo sapiens_hsa04114	0.44005652
88	Retinol metabolism_Homo sapiens_hsa00830	0.42930431
89	Bile secretion_Homo sapiens_hsa04976	0.42909827
90	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.42558790
91	Type I diabetes mellitus_Homo sapiens_hsa04940	0.40830524
92	Glucagon signaling pathway_Homo sapiens_hsa04922	0.40469188
93	Homologous recombination_Homo sapiens_hsa03440	0.38715116
94	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.38619349
95	Calcium signaling pathway_Homo sapiens_hsa04020	0.38231095
96	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.38097912
97	Cholinergic synapse_Homo sapiens_hsa04725	0.37538436
98	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.37523902
99	Non-homologous end-joining_Homo sapiens_hsa03450	0.34348065
100	Alcoholism_Homo sapiens_hsa05034	0.31588322

HADHAP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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