HADHB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. The encoded protein can also bind RNA and decreases the stability of some mRNAs. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. Mutations in this gene result in trifunctional protein deficiency. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)7.01900262
2carnitine shuttle (GO:0006853)6.60104338
3fatty acid transmembrane transport (GO:1902001)6.30543502
4regulation of sequestering of triglyceride (GO:0010889)6.17233328
5regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)6.01695009
6* fatty acid beta-oxidation (GO:0006635)5.79805565
7actin-mediated cell contraction (GO:0070252)5.58808607
8regulation of acyl-CoA biosynthetic process (GO:0050812)5.48269003
9carnitine transmembrane transport (GO:1902603)5.25694026
10lysine metabolic process (GO:0006553)5.18402942
11lysine catabolic process (GO:0006554)5.18402942
12NADH metabolic process (GO:0006734)5.11485061
13* fatty acid oxidation (GO:0019395)5.05781777
14* fatty acid catabolic process (GO:0009062)5.05259801
15branched-chain amino acid catabolic process (GO:0009083)5.01656986
16sarcoplasmic reticulum calcium ion transport (GO:0070296)5.01037120
17* lipid oxidation (GO:0034440)4.98929335
18amino-acid betaine transport (GO:0015838)4.98706685
19carnitine transport (GO:0015879)4.98706685
20regulation of cofactor metabolic process (GO:0051193)4.98475070
21regulation of coenzyme metabolic process (GO:0051196)4.98475070
22regulation of fatty acid oxidation (GO:0046320)4.85848912
23acetyl-CoA metabolic process (GO:0006084)4.79812728
242-oxoglutarate metabolic process (GO:0006103)4.77640350
25biotin metabolic process (GO:0006768)4.76926732
26short-chain fatty acid metabolic process (GO:0046459)4.64343289
27succinate metabolic process (GO:0006105)4.63297899
28respiratory electron transport chain (GO:0022904)4.55109150
29aspartate family amino acid catabolic process (GO:0009068)4.54411709
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.53316340
31branched-chain amino acid metabolic process (GO:0009081)4.50648853
32valine metabolic process (GO:0006573)4.45238690
33electron transport chain (GO:0022900)4.42139552
34positive regulation of fatty acid oxidation (GO:0046321)4.41065224
35striated muscle contraction (GO:0006941)4.37969767
36carnitine metabolic process (GO:0009437)4.31712883
37* monocarboxylic acid catabolic process (GO:0072329)4.31592420
38skeletal muscle contraction (GO:0003009)4.28684197
39mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.26517053
40sarcomere organization (GO:0045214)4.26382659
41regulation of sulfur metabolic process (GO:0042762)4.22219658
42cellular ketone body metabolic process (GO:0046950)4.19371979
43tricarboxylic acid metabolic process (GO:0072350)4.16206094
44positive regulation of fatty acid beta-oxidation (GO:0032000)4.13938754
45negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.05344240
46actin filament-based movement (GO:0030048)4.04639308
47regulation of triglyceride catabolic process (GO:0010896)4.02901432
48quaternary ammonium group transport (GO:0015697)3.95423332
49oxidative phosphorylation (GO:0006119)3.94741199
50amino-acid betaine metabolic process (GO:0006577)3.93290113
51cardiac myofibril assembly (GO:0055003)3.90847167
52acyl-CoA biosynthetic process (GO:0071616)3.90715427
53thioester biosynthetic process (GO:0035384)3.90715427
54energy coupled proton transport, down electrochemical gradient (GO:0015985)3.88576594
55ATP synthesis coupled proton transport (GO:0015986)3.88576594
56fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.88186787
57regulation of cell communication by electrical coupling (GO:0010649)3.87181324
58regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.80682669
59alpha-linolenic acid metabolic process (GO:0036109)3.79602373
60response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.78686141
61glyoxylate metabolic process (GO:0046487)3.78593267
62regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.76512462
63heart contraction (GO:0060047)3.69526918
64heart process (GO:0003015)3.69526918
65response to muscle activity (GO:0014850)3.66163820
66ketone body metabolic process (GO:1902224)3.65599283
67cardiac muscle hypertrophy (GO:0003300)3.65352047
68regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.64446845
69negative regulation of potassium ion transmembrane transport (GO:1901380)3.59690729
70negative regulation of fatty acid biosynthetic process (GO:0045717)3.57185381
71actomyosin structure organization (GO:0031032)3.55865220
72thioester metabolic process (GO:0035383)3.55147278
73acyl-CoA metabolic process (GO:0006637)3.55147278
74oxaloacetate metabolic process (GO:0006107)3.54672819
75gluconeogenesis (GO:0006094)3.54101693
76intracellular lipid transport (GO:0032365)3.52735270
77glycogen catabolic process (GO:0005980)3.51793016
78myofibril assembly (GO:0030239)3.51383880
79bundle of His cell to Purkinje myocyte communication (GO:0086069)3.49705428
80fatty acid homeostasis (GO:0055089)3.48444133
81L-phenylalanine catabolic process (GO:0006559)3.48334201
82erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.48334201
83striated muscle hypertrophy (GO:0014897)3.47158283
84glucan catabolic process (GO:0009251)3.44105545
85regulation of relaxation of muscle (GO:1901077)3.43444261
86erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.42051003
87L-phenylalanine metabolic process (GO:0006558)3.42051003
88regulation of the force of heart contraction (GO:0002026)3.39154530
89positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.36239630
90ethanol oxidation (GO:0006069)3.35348442
91muscle filament sliding (GO:0030049)3.34757274
92actin-myosin filament sliding (GO:0033275)3.34757274
93creatine metabolic process (GO:0006600)3.34617732
94triglyceride catabolic process (GO:0019433)3.32149841
95cellular polysaccharide catabolic process (GO:0044247)3.31863292
96cardiac muscle contraction (GO:0060048)3.28701411
97cardiac muscle tissue morphogenesis (GO:0055008)3.27456021
98regulation of actin filament-based movement (GO:1903115)3.25721391
99* carboxylic acid catabolic process (GO:0046395)3.24590610
100* organic acid catabolic process (GO:0016054)3.24590610
101regulation of cholesterol metabolic process (GO:0090181)3.23917467
102regulation of fatty acid beta-oxidation (GO:0031998)3.23033170
103negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.21499574
104regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.21325614
105fructose metabolic process (GO:0006000)3.20550472
106hexose biosynthetic process (GO:0019319)3.19446646
107lipid particle organization (GO:0034389)3.18704057
108regulation of skeletal muscle contraction (GO:0014819)3.14794469
109triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.14639985
110brown fat cell differentiation (GO:0050873)3.14540532
111negative regulation of fatty acid metabolic process (GO:0045922)3.14531230
112muscle hypertrophy (GO:0014896)3.14163378
113regulation of fatty acid metabolic process (GO:0019217)3.12814999
114muscle contraction (GO:0006936)3.09805743
115positive regulation of lipid storage (GO:0010884)3.08634002
116neutral lipid catabolic process (GO:0046461)3.07906432
117acylglycerol catabolic process (GO:0046464)3.07906432
118ventricular cardiac muscle cell action potential (GO:0086005)3.07864701
119muscle tissue morphogenesis (GO:0060415)3.07122804
120positive regulation of lipid catabolic process (GO:0050996)3.05687125
121polysaccharide catabolic process (GO:0000272)3.05224900
122response to epinephrine (GO:0071871)3.04598600
123glycogen biosynthetic process (GO:0005978)3.04018053
124glucan biosynthetic process (GO:0009250)3.04018053
125epoxygenase P450 pathway (GO:0019373)3.01435016
126quinone biosynthetic process (GO:1901663)2.99538550
127ubiquinone biosynthetic process (GO:0006744)2.99538550
128regulation of striated muscle contraction (GO:0006942)2.98585536
129heart trabecula formation (GO:0060347)2.98031897
130low-density lipoprotein particle clearance (GO:0034383)2.95952247
131cardiac muscle cell development (GO:0055013)2.95017294
132long-chain fatty acid transport (GO:0015909)2.92578659
133regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.92408258
134monosaccharide biosynthetic process (GO:0046364)2.92117314
135phospholipid homeostasis (GO:0055091)2.91781618
136regulation of cholesterol esterification (GO:0010872)2.89996933
137fatty-acyl-CoA metabolic process (GO:0035337)2.89664672
138response to inactivity (GO:0014854)2.85616609
139dicarboxylic acid biosynthetic process (GO:0043650)2.83309736
140regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.83253264
141angiotensin maturation (GO:0002003)2.82965815
142ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.82805106
143adult heart development (GO:0007512)2.79960174
144muscle system process (GO:0003012)2.78051590
145cellular response to epinephrine stimulus (GO:0071872)2.76556551
146regulation of cardiac muscle cell contraction (GO:0086004)2.74495875
147peroxisome fission (GO:0016559)2.73997028

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.46203251
2TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse5.36015444
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.08141905
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.58703071
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.29230911
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.68223689
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.51726325
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.42314420
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.16162011
10* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.98359996
11CLOCK_20551151_ChIP-Seq_293T_Human2.60410792
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.60323731
13EP300_21415370_ChIP-Seq_HL-1_Mouse2.53379727
14GATA1_22025678_ChIP-Seq_K562_Human2.52124815
15TBX20_22328084_ChIP-Seq_HEART_Mouse2.14815695
16TBX20_22080862_ChIP-Seq_HEART_Mouse2.14815695
17* PPARG_19300518_ChIP-PET_3T3-L1_Mouse10.2153252
18RARG_19884340_ChIP-ChIP_MEFs_Mouse1.84404021
19* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.79694019
20* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.78241824
21ZNF263_19887448_ChIP-Seq_K562_Human1.74566360
22ESR1_20079471_ChIP-ChIP_T-47D_Human1.73679306
23ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.73343129
24CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59309345
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.51848339
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51780743
27TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.48777821
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.48759085
29* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.46755197
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.45396167
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43795489
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39620706
33MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.33893158
34BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29444943
35* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.26420404
36* FOXA2_19822575_ChIP-Seq_HepG2_Human1.19461813
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19441094
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14523320
39* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.12478306
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.10369611
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07811286
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06902136
43AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04591159
44NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04492520
45NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04492520
46HTT_18923047_ChIP-ChIP_STHdh_Human1.03955512
47* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03752313
48PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.03193629
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99079767
50NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98139977
51STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97972657
52EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96132407
53BCAT_22108803_ChIP-Seq_LS180_Human0.95913096
54EOMES_21245162_ChIP-Seq_HESCs_Human0.95776902
55NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95504741
56* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94900161
57* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94494958
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94236031
59NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94019246
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93991218
61SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90099462
62* HNF4A_19822575_ChIP-Seq_HepG2_Human0.89190152
63ESR2_21235772_ChIP-Seq_MCF-7_Human0.88482676
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87589063
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.86989101
66SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85797952
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85738601
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85390544
69AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84829214
70GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.83467554
71CDX2_20551321_ChIP-Seq_CACO-2_Human0.82101764
72NFIB_24661679_ChIP-Seq_LUNG_Mouse0.81826006
73ESR1_21235772_ChIP-Seq_MCF-7_Human0.80154429
74ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.79880436
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79784897
76HIF1A_21447827_ChIP-Seq_MCF-7_Human0.78731294
77FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78548776
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78290150
79GATA1_19941826_ChIP-Seq_K562_Human0.78241686
80TP63_17297297_ChIP-ChIP_HaCaT_Human0.77576237
81* SRF_21415370_ChIP-Seq_HL-1_Mouse0.76817761
82TRIM28_21343339_ChIP-Seq_HEK293_Human0.76524214
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.75395689
84CEBPB_22108803_ChIP-Seq_LS180_Human0.74666788
85TBX5_21415370_ChIP-Seq_HL-1_Mouse0.73714129
86GATA4_25053715_ChIP-Seq_YYC3_Human0.73422728
87PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.72566896
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72183705
89VDR_22108803_ChIP-Seq_LS180_Human0.71344510
90EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.71249708
91AR_20517297_ChIP-Seq_VCAP_Human0.71035563
92SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.70918996
93CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.69748102
94ERG_20517297_ChIP-Seq_VCAP_Human0.69155230
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.69136633
96TFEB_21752829_ChIP-Seq_HELA_Human0.69001409
97CBP_21632823_ChIP-Seq_H3396_Human0.68939308
98GATA2_21666600_ChIP-Seq_HMVEC_Human0.68538208
99HNFA_21074721_ChIP-Seq_CACO-2_Human0.68175290
100SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.66150881
101SALL4_18804426_ChIP-ChIP_XEN_Mouse0.66112450
102P63_26484246_Chip-Seq_KERATINOCYTES_Human0.65964109
103GATA2_19941826_ChIP-Seq_K562_Human0.65521606
104NR3C1_23031785_ChIP-Seq_PC12_Mouse0.64859621
105PIAS1_25552417_ChIP-Seq_VCAP_Human0.64841051
106FOXO3_23340844_ChIP-Seq_DLD1_Human0.63015747
107FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.62957750
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.61557452
109FOXH1_21741376_ChIP-Seq_ESCs_Human0.61063383
110* EGR1_19032775_ChIP-ChIP_M12_Human0.60779745
111GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.60455542
112GATA3_24758297_ChIP-Seq_MCF-7_Human0.60432966
113FOXA1_25552417_ChIP-Seq_VCAP_Human0.59481757
114SOX2_20726797_ChIP-Seq_SW620_Human0.58245923
115RAD21_21589869_ChIP-Seq_MESCs_Mouse0.58107593
116CJUN_26792858_Chip-Seq_BT549_Human0.57910312
117WT1_19549856_ChIP-ChIP_CCG9911_Human0.57333315
118TAF2_19829295_ChIP-Seq_ESCs_Human0.56501224
119CDX2_22108803_ChIP-Seq_LS180_Human0.56477878
120OCT4_20526341_ChIP-Seq_ESCs_Human0.54930954
121SOX9_24532713_ChIP-Seq_HFSC_Mouse0.53881686
122BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.52402036
123* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.52159411
124SOX2_19829295_ChIP-Seq_ESCs_Human0.52127524
125NANOG_19829295_ChIP-Seq_ESCs_Human0.52127524
126CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.51101307
127CBP_20019798_ChIP-Seq_JUKART_Human0.50918673
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.50918673
129LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.50156777

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.16746493
2MP0003646_muscle_fatigue4.36170138
3MP0004130_abnormal_muscle_cell3.67014298
4MP0005670_abnormal_white_adipose3.58036099
5MP0004084_abnormal_cardiac_muscle3.57454955
6MP0002139_abnormal_hepatobiliary_system3.45726763
7MP0004215_abnormal_myocardial_fiber3.42271541
8MP0000751_myopathy3.13183466
9* MP0005330_cardiomyopathy2.95811534
10MP0004036_abnormal_muscle_relaxation2.93118774
11MP0005666_abnormal_adipose_tissue2.91966451
12MP0005085_abnormal_gallbladder_physiolo2.91278460
13MP0005360_urolithiasis2.89918121
14MP0006036_abnormal_mitochondrial_physio2.78633937
15MP0005365_abnormal_bile_salt2.75597590
16MP0000749_muscle_degeneration2.59793132
17MP0003806_abnormal_nucleotide_metabolis2.57549032
18MP0008775_abnormal_heart_ventricle2.25110222
19MP0002972_abnormal_cardiac_muscle2.24667711
20* MP0004087_abnormal_muscle_fiber2.13775276
21MP0005332_abnormal_amino_acid2.12870257
22MP0004185_abnormal_adipocyte_glucose2.08805221
23MP0003195_calcinosis2.08302863
24MP0010329_abnormal_lipoprotein_level2.03972760
25MP0005620_abnormal_muscle_contractility2.00252110
26MP0008875_abnormal_xenobiotic_pharmacok1.93888584
27MP0005375_adipose_tissue_phenotype1.90354175
28* MP0002971_abnormal_brown_adipose1.89371955
29* MP0005385_cardiovascular_system_phenoty1.89348470
30* MP0001544_abnormal_cardiovascular_syste1.89348470
31MP0006138_congestive_heart_failure1.82761807
32MP0004484_altered_response_of1.77184417
33* MP0002118_abnormal_lipid_homeostasis1.75827145
34MP0005058_abnormal_lysosome_morphology1.72973454
35MP0000750_abnormal_muscle_regeneration1.71804372
36* MP0010630_abnormal_cardiac_muscle1.70393009
37MP0004043_abnormal_pH_regulation1.67582549
38MP0002106_abnormal_muscle_physiology1.66003439
39MP0003221_abnormal_cardiomyocyte_apopto1.65938380
40* MP0003137_abnormal_impulse_conducting1.63770073
41MP0002269_muscular_atrophy1.62671863
42MP0005535_abnormal_body_temperature1.57056993
43MP0000747_muscle_weakness1.49623673
44MP0006035_abnormal_mitochondrial_morpho1.47408402
45MP0003252_abnormal_bile_duct1.45164976
46MP0005584_abnormal_enzyme/coenzyme_acti1.41152588
47MP0002332_abnormal_exercise_endurance1.40634598
48MP0009840_abnormal_foam_cell1.39502469
49MP0000013_abnormal_adipose_tissue1.39209441
50MP0004145_abnormal_muscle_electrophysio1.36955756
51MP0009780_abnormal_chondrocyte_physiolo1.33945982
52MP0005319_abnormal_enzyme/_coenzyme1.33668233
53MP0005369_muscle_phenotype1.32046332
54MP0003950_abnormal_plasma_membrane1.31524681
55MP0003191_abnormal_cellular_cholesterol1.31313576
56MP0005451_abnormal_body_composition1.27602667
57MP0003828_pulmonary_edema1.26727914
58* MP0004085_abnormal_heartbeat1.26597257
59* MP0000609_abnormal_liver_physiology1.26546437
60* MP0000759_abnormal_skeletal_muscle1.24565305
61MP0000003_abnormal_adipose_tissue1.22630324
62* MP0002078_abnormal_glucose_homeostasis1.21464326
63MP0001661_extended_life_span1.18499865
64MP0009643_abnormal_urine_homeostasis1.18023080
65MP0005334_abnormal_fat_pad1.15704117
66MP0003186_abnormal_redox_activity1.15454622
67MP0001666_abnormal_nutrient_absorption1.11606140
68MP0003868_abnormal_feces_composition1.08838317
69MP0000230_abnormal_systemic_arterial1.08078081
70MP0005266_abnormal_metabolism1.04556765
71MP0003011_delayed_dark_adaptation1.03131029
72MP0005165_increased_susceptibility_to1.01757795
73MP0000343_altered_response_to1.00778691
74MP0005083_abnormal_biliary_tract0.99011796
75MP0004147_increased_porphyrin_level0.94337786
76MP0002127_abnormal_cardiovascular_syste0.94037154
77MP0009115_abnormal_fat_cell0.92572574
78MP0004233_abnormal_muscle_weight0.90279173
79MP0005166_decreased_susceptibility_to0.86790883
80MP0002970_abnormal_white_adipose0.86709302
81MP0003690_abnormal_glial_cell0.85524457
82MP0003075_altered_response_to0.82282321
83MP0010368_abnormal_lymphatic_system0.80474039
84MP0001764_abnormal_homeostasis0.79115864
85MP0008438_abnormal_cutaneous_collagen0.77680603
86MP0005448_abnormal_energy_balance0.73478965
87MP0001756_abnormal_urination0.71989545
88MP0000733_abnormal_muscle_development0.71160030
89MP0000372_irregular_coat_pigmentation0.69208704
90MP0005167_abnormal_blood-brain_barrier0.68745293
91MP0004019_abnormal_vitamin_homeostasis0.67512334
92MP0005452_abnormal_adipose_tissue0.63950525
93MP0005376_homeostasis/metabolism_phenot0.61410968
94MP0001853_heart_inflammation0.60837625
95MP0002876_abnormal_thyroid_physiology0.60622550
96MP0003329_amyloid_beta_deposits0.59832652
97MP0003941_abnormal_skin_development0.59674360
98MP0003567_abnormal_fetal_cardiomyocyte0.58037288
99MP0004272_abnormal_basement_membrane0.58003536
100MP0000604_amyloidosis0.57458884
101* MP0000266_abnormal_heart_morphology0.57398872
102MP0005275_abnormal_skin_tensile0.57388492
103MP0002108_abnormal_muscle_morphology0.56823141
104MP0000249_abnormal_blood_vessel0.56697690
105MP0001879_abnormal_lymphatic_vessel0.56595230
106MP0004510_myositis0.56363061
107MP0010234_abnormal_vibrissa_follicle0.55919742
108MP0003656_abnormal_erythrocyte_physiolo0.55618571
109* MP0009642_abnormal_blood_homeostasis0.55377663
110MP0009763_increased_sensitivity_to0.54427019
111MP0003953_abnormal_hormone_level0.54399679
112MP0005636_abnormal_mineral_homeostasis0.53758359
113MP0003279_aneurysm0.53683839
114MP0009697_abnormal_copulation0.53052863
115MP0003959_abnormal_lean_body0.51747441
116MP0002132_abnormal_respiratory_system0.50492500

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.40818738
2Nemaline bodies (HP:0003798)6.36255109
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.28005479
4Hypoglycemic coma (HP:0001325)5.37270230
5Type 1 muscle fiber predominance (HP:0003803)5.07308676
6* Myoglobinuria (HP:0002913)4.96934564
7Abnormality of fatty-acid metabolism (HP:0004359)4.96486801
8Sudden death (HP:0001699)4.60290841
9Abnormality of dicarboxylic acid metabolism (HP:0010995)4.57987297
10Dicarboxylic aciduria (HP:0003215)4.57987297
11Hepatic necrosis (HP:0002605)4.53849507
12Exercise-induced myalgia (HP:0003738)4.49559594
13Hyperglycinuria (HP:0003108)4.47554146
14Ketoacidosis (HP:0001993)4.37249140
15Ventricular tachycardia (HP:0004756)4.06917367
16Ketosis (HP:0001946)4.00231342
17Abnormality of glycine metabolism (HP:0010895)3.92348408
18Abnormality of serine family amino acid metabolism (HP:0010894)3.92348408
19* Rhabdomyolysis (HP:0003201)3.86016668
20Increased muscle lipid content (HP:0009058)3.85820056
21Distal lower limb muscle weakness (HP:0009053)3.79400390
22Cerebral edema (HP:0002181)3.79173367
23Palpitations (HP:0001962)3.78412021
24Acute encephalopathy (HP:0006846)3.78096048
25Abnormal mitochondria in muscle tissue (HP:0008316)3.75192383
26Calf muscle hypertrophy (HP:0008981)3.73516760
27Neck muscle weakness (HP:0000467)3.72279708
28Generalized aminoaciduria (HP:0002909)3.70691397
29Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.68365978
30Acute necrotizing encephalopathy (HP:0006965)3.65871764
31Centrally nucleated skeletal muscle fibers (HP:0003687)3.65705238
32* Hyperammonemia (HP:0001987)3.64469553
33Exercise-induced muscle cramps (HP:0003710)3.61662143
34Hepatocellular necrosis (HP:0001404)3.54139683
35Muscle hypertrophy of the lower extremities (HP:0008968)3.50847191
36Lipoatrophy (HP:0100578)3.40654537
37Atrial fibrillation (HP:0005110)3.36912180
38Right ventricular cardiomyopathy (HP:0011663)3.33385258
39Muscle fiber splitting (HP:0003555)3.25905133
40Hyporeflexia of lower limbs (HP:0002600)3.22953531
41Abnormality of skeletal muscle fiber size (HP:0012084)3.22811751
42Rimmed vacuoles (HP:0003805)3.15125167
43Progressive macrocephaly (HP:0004481)3.11977563
44Myopathic facies (HP:0002058)3.11832176
45Increased CSF lactate (HP:0002490)3.09107971
46Mitochondrial inheritance (HP:0001427)3.07090393
47Primary atrial arrhythmia (HP:0001692)3.04908208
48* Dilated cardiomyopathy (HP:0001644)3.03738967
49Hyperglycinemia (HP:0002154)3.02541394
50Abnormality of glycolysis (HP:0004366)3.02336856
51Increased serum pyruvate (HP:0003542)3.02336856
52Increased intramyocellular lipid droplets (HP:0012240)3.01660829
53* Lactic acidosis (HP:0003128)3.01565085
54Renal cortical cysts (HP:0000803)2.99460406
55Lethargy (HP:0001254)2.99309374
56Syncope (HP:0001279)2.98522906
57Distal arthrogryposis (HP:0005684)2.96931393
58Proximal tubulopathy (HP:0000114)2.93843902
59Supraventricular tachycardia (HP:0004755)2.93342907
60Nausea (HP:0002018)2.93143737
61Hypoalphalipoproteinemia (HP:0003233)2.91635272
62Supraventricular arrhythmia (HP:0005115)2.87279055
63Increased variability in muscle fiber diameter (HP:0003557)2.87173242
64Metabolic acidosis (HP:0001942)2.85195785
65Abnormality of the calf musculature (HP:0001430)2.84561898
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.77558544
67Abnormality of alanine metabolism (HP:0010916)2.77558544
68Hyperalaninemia (HP:0003348)2.77558544
69Lipid accumulation in hepatocytes (HP:0006561)2.75152621
70Xanthomatosis (HP:0000991)2.74483615
71Atrioventricular block (HP:0001678)2.72765562
72Round ear (HP:0100830)2.69902693
73Bundle branch block (HP:0011710)2.69878658
74Conjunctival hamartoma (HP:0100780)2.68579698
75Hyperinsulinemic hypoglycemia (HP:0000825)2.65347230
76Hyperlipoproteinemia (HP:0010980)2.65311948
77Muscle stiffness (HP:0003552)2.62515836
78Difficulty running (HP:0009046)2.60525564
79Heart block (HP:0012722)2.59348653
80Pheochromocytoma (HP:0002666)2.56438195
81EMG: neuropathic changes (HP:0003445)2.55858854
82Vomiting (HP:0002013)2.52451122
83Abnormality of serum amino acid levels (HP:0003112)2.52274939
84Methylmalonic aciduria (HP:0012120)2.50805133
85Asymmetric septal hypertrophy (HP:0001670)2.50460092
86Ulnar deviation of the wrist (HP:0003049)2.47431675
87Abnormality of aromatic amino acid family metabolism (HP:0004338)2.45317569
88Increased connective tissue (HP:0009025)2.44669228
89Exercise intolerance (HP:0003546)2.43608967
90Ventricular arrhythmia (HP:0004308)2.42716523
91Abnormal atrioventricular conduction (HP:0005150)2.39812967
92Complement deficiency (HP:0004431)2.39795566
93* Respiratory failure (HP:0002878)2.38061442
94Prolonged QT interval (HP:0001657)2.37971614
95Intrahepatic cholestasis (HP:0001406)2.37411911
96Frequent falls (HP:0002359)2.33606587
97Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.33460389
98Decreased activity of mitochondrial respiratory chain (HP:0008972)2.33460389
99Neuroendocrine neoplasm (HP:0100634)2.31612676
100Hypolipoproteinemia (HP:0010981)2.31347250
101Mildly elevated creatine phosphokinase (HP:0008180)2.30838131
102Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.30360889
103Glycosuria (HP:0003076)2.30168902
104Abnormality of urine glucose concentration (HP:0011016)2.30168902
105Ventricular fibrillation (HP:0001663)2.28342239
106Systemic lupus erythematosus (HP:0002725)2.27523549
107Areflexia of lower limbs (HP:0002522)2.26990115
108Methylmalonic acidemia (HP:0002912)2.24986234
109EMG: myopathic abnormalities (HP:0003458)2.19653420
110Ragged-red muscle fibers (HP:0003200)2.19587027
111Hyperglycemia (HP:0003074)2.18911018
112Oligomenorrhea (HP:0000876)2.17948471
113Subaortic stenosis (HP:0001682)2.17579685
114Abnormality of the left ventricular outflow tract (HP:0011103)2.17579685
115Hypoglycemic seizures (HP:0002173)2.15538164
116Increased serum lactate (HP:0002151)2.13553504
117Bulbar palsy (HP:0001283)2.12485110
118Insulin-resistant diabetes mellitus (HP:0000831)2.10225584
119Abnormality of aspartate family amino acid metabolism (HP:0010899)2.08909333
120Gowers sign (HP:0003391)2.05135369
121* Generalized muscle weakness (HP:0003324)2.05038154
122Neoplasm of the adrenal gland (HP:0100631)2.04566059
123Esophageal neoplasm (HP:0100751)2.03172153
124Neoplasm of head and neck (HP:0012288)2.03172153
125Skin nodule (HP:0200036)2.00999766
126Abnormality of the foot musculature (HP:0001436)1.97227513
127Distal lower limb amyotrophy (HP:0008944)1.95891558
128Abnormality of liposaccharide metabolism (HP:0010968)1.91520766
129Abnormality of glycosphingolipid metabolism (HP:0004343)1.91520766
130Abnormality of glycolipid metabolism (HP:0010969)1.91520766
131Abnormality of glutamine family amino acid metabolism (HP:0010902)1.89353166
132Progressive muscle weakness (HP:0003323)1.87826191
133Abnormality of complement system (HP:0005339)1.81544173
134Foot dorsiflexor weakness (HP:0009027)1.77236561
135Axonal loss (HP:0003447)1.75359280
136Abnormality of monocarboxylic acid metabolism (HP:0010996)1.73789878
137Limb-girdle muscle atrophy (HP:0003797)1.73405338
138Scapular winging (HP:0003691)1.73370615
139Myotonia (HP:0002486)1.73008091
140Weak cry (HP:0001612)1.71498674
141Hydroxyprolinuria (HP:0003080)1.69632382
142Abnormality of proline metabolism (HP:0010907)1.69632382

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.26321646
2PDK44.77494718
3PDK34.77494718
4TTN3.73141897
5LMTK23.48364108
6OBSCN3.48288951
7PDK23.18287060
8PHKG13.00013397
9PHKG23.00013397
10TRIB32.89216940
11PKN22.51957847
12MYLK2.49947653
13TIE12.28573109
14PINK12.18324988
15INSRR2.13120606
16WNK41.77772702
17PIK3CA1.77498384
18MUSK1.67091462
19LIMK11.65169279
20STK241.62238658
21NEK11.60627276
22SIK11.60037772
23STK391.49339517
24PRKAA21.48060831
25CAMK1D1.42888971
26DMPK1.42104131
27FLT31.41603942
28MAP3K121.39573232
29GRK71.38185468
30STK161.33589650
31TESK11.26237185
32SCYL21.21495555
33STK38L1.21461581
34NEK91.09180449
35EIF2AK31.08812229
36EPHB11.05500009
37CAMK2D1.02797827
38ZAK1.00784527
39MAP3K21.00255954
40FGFR40.98463722
41KDR0.95661110
42PRKAA10.95504473
43PRKD10.93649216
44PBK0.89018555
45ACVR1B0.88641345
46IRAK30.86753444
47ERBB30.85847895
48KSR20.85650183
49PAK30.84041632
50PIK3CG0.83522504
51MAPK120.80652620
52MAP2K60.78745419
53CAMK1G0.78323372
54PDPK10.77341740
55EPHA30.76175298
56TBK10.75612296
57MST1R0.74668576
58MAP3K70.70805507
59MAP2K30.70803883
60ILK0.68846131
61MOS0.68835138
62PKN10.68189845
63MAP3K30.67485439
64ERN10.66499557
65FGFR30.66000038
66EIF2AK10.65778219
67PRKACG0.61584031
68LATS10.60813834
69MAP3K60.60424792
70ROCK10.58656002
71WNK10.57918835
72IRAK10.57455622
73CAMK2G0.57406327
74PDK10.56653238
75ZAP700.53402699
76MAP3K10.52248781
77TGFBR20.51391035
78DAPK30.51198353
79LATS20.49431772
80RIPK10.48936992
81DDR20.48723766
82WNK30.47317068
83PRKACA0.46419506
84MAPK110.46173639
85IRAK20.45389054
86NME20.44667387
87MET0.44478666
88MAPK70.44342362
89JAK10.42686189
90PIM20.42634852
91FGFR20.42173683
92TRPM70.41927607
93CAMK2A0.39898216
94PTK60.39676547
95CAMK40.38360156
96OXSR10.38353160
97PRKCE0.38351508
98PRKG10.37761561
99FRK0.37583650
100CAMK2B0.36726810
101ABL20.36675880
102MAP2K10.36612619
103DYRK1B0.35667959
104MAPKAPK30.35473067
105STK40.35058118
106PRKCH0.34807631
107PRKACB0.34527799
108PRKCQ0.34273200
109CDK60.33904351
110CDC42BPA0.33787958
111PDGFRA0.33749858
112JAK20.32274695
113RAF10.31702491
114CAMK10.31156128
115MAP3K50.30662466
116TYK20.30615114
117MAP2K40.30467389
118PAK40.29344887
119PTK20.28967669
120CCNB10.28134441
121SGK2230.26626665
122SGK4940.26626665
123KIT0.26479709
124MAPK150.24061514
125ERBB40.23076544
126ROCK20.22030345
127GSK3A0.21684133
128IGF1R0.20484400
129SGK30.20393779
130AKT20.20089757
131FER0.19653631
132RET0.19054238
133MAPK40.18499957
134PRKG20.14959201

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.98579689
2Propanoate metabolism_Homo sapiens_hsa006404.33884036
3* Fatty acid degradation_Homo sapiens_hsa000713.81877445
4* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.55302489
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.54217301
6* Fatty acid metabolism_Homo sapiens_hsa012123.25084032
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.74101197
8Pyruvate metabolism_Homo sapiens_hsa006202.44935318
9Butanoate metabolism_Homo sapiens_hsa006502.44699857
10PPAR signaling pathway_Homo sapiens_hsa033202.44065886
11Carbon metabolism_Homo sapiens_hsa012002.43714304
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.31431829
13* Fatty acid elongation_Homo sapiens_hsa000622.29409045
14Oxidative phosphorylation_Homo sapiens_hsa001902.22837029
15Parkinsons disease_Homo sapiens_hsa050122.11070188
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.09644511
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05147419
18Tryptophan metabolism_Homo sapiens_hsa003801.97264070
19Peroxisome_Homo sapiens_hsa041461.90434589
20beta-Alanine metabolism_Homo sapiens_hsa004101.76571701
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.74762980
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.70553230
23Fatty acid biosynthesis_Homo sapiens_hsa000611.67599776
24Cardiac muscle contraction_Homo sapiens_hsa042601.66918761
25Alzheimers disease_Homo sapiens_hsa050101.53463722
26Nitrogen metabolism_Homo sapiens_hsa009101.53240327
27Other glycan degradation_Homo sapiens_hsa005111.52699311
28Arginine biosynthesis_Homo sapiens_hsa002201.42645204
29Sulfur metabolism_Homo sapiens_hsa009201.38799998
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29915668
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27263382
32Huntingtons disease_Homo sapiens_hsa050161.26365775
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18388665
34Biosynthesis of amino acids_Homo sapiens_hsa012301.15787411
35Starch and sucrose metabolism_Homo sapiens_hsa005001.13567727
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13370494
37Phenylalanine metabolism_Homo sapiens_hsa003601.12762528
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01129492
39Tyrosine metabolism_Homo sapiens_hsa003501.00767258
40Fat digestion and absorption_Homo sapiens_hsa049750.99958118
41Glycerolipid metabolism_Homo sapiens_hsa005610.99940945
42Dilated cardiomyopathy_Homo sapiens_hsa054140.96010208
43Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95877709
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93657616
45Renin-angiotensin system_Homo sapiens_hsa046140.92661386
46Adipocytokine signaling pathway_Homo sapiens_hsa049200.92420651
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90905033
48Glycosaminoglycan degradation_Homo sapiens_hsa005310.88700512
49Caffeine metabolism_Homo sapiens_hsa002320.85193618
50Complement and coagulation cascades_Homo sapiens_hsa046100.82694460
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81330215
52Arginine and proline metabolism_Homo sapiens_hsa003300.79821891
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77197657
54Histidine metabolism_Homo sapiens_hsa003400.76696008
55Lysine degradation_Homo sapiens_hsa003100.73796112
56Insulin resistance_Homo sapiens_hsa049310.73575947
57Chemical carcinogenesis_Homo sapiens_hsa052040.73467563
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73067816
59Mineral absorption_Homo sapiens_hsa049780.72280478
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70781787
61Glucagon signaling pathway_Homo sapiens_hsa049220.69474200
62ABC transporters_Homo sapiens_hsa020100.65998356
63Bile secretion_Homo sapiens_hsa049760.65962533
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.64383010
65* Metabolic pathways_Homo sapiens_hsa011000.62608615
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61544868
67AMPK signaling pathway_Homo sapiens_hsa041520.58319817
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57711404
69Selenocompound metabolism_Homo sapiens_hsa004500.57690791
70Retinol metabolism_Homo sapiens_hsa008300.57272015
71Lysosome_Homo sapiens_hsa041420.56340521
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54980565
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.53331963
74Glutathione metabolism_Homo sapiens_hsa004800.50853410
75Pentose phosphate pathway_Homo sapiens_hsa000300.50353928
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46391665
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43710044
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.42315056
79Insulin signaling pathway_Homo sapiens_hsa049100.42270332
80Folate biosynthesis_Homo sapiens_hsa007900.42191346
81Vitamin B6 metabolism_Homo sapiens_hsa007500.39694809
82Fructose and mannose metabolism_Homo sapiens_hsa000510.39172035
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38850513
84Galactose metabolism_Homo sapiens_hsa000520.37574840
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37337280
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.35861459
87Renin secretion_Homo sapiens_hsa049240.33470721
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.32336923
89Staphylococcus aureus infection_Homo sapiens_hsa051500.30636233
90Proteasome_Homo sapiens_hsa030500.28511769
91Sulfur relay system_Homo sapiens_hsa041220.28196446
92Linoleic acid metabolism_Homo sapiens_hsa005910.27833185
93Prion diseases_Homo sapiens_hsa050200.26830573
94Vitamin digestion and absorption_Homo sapiens_hsa049770.26570745
95Steroid biosynthesis_Homo sapiens_hsa001000.24943223
96Sphingolipid metabolism_Homo sapiens_hsa006000.21898386
97Viral myocarditis_Homo sapiens_hsa054160.19355329
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.16391857
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.16387846
100Protein digestion and absorption_Homo sapiens_hsa049740.15048237
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.13339201
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.12819719
103Ovarian steroidogenesis_Homo sapiens_hsa049130.08465273
104Arachidonic acid metabolism_Homo sapiens_hsa005900.07140298
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.06715536
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.03271874
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.02754630
108Circadian rhythm_Homo sapiens_hsa047100.02417268
109ECM-receptor interaction_Homo sapiens_hsa04512-0.0552145
110HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0303557
111Cyanoamino acid metabolism_Homo sapiens_hsa00460-0.0229297
112Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0056880

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »