HAGH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.19716350
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.19716350
3L-phenylalanine metabolic process (GO:0006558)6.86430676
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.86430676
5aromatic amino acid family catabolic process (GO:0009074)6.23132478
6tryptophan catabolic process (GO:0006569)5.40366416
7indole-containing compound catabolic process (GO:0042436)5.40366416
8indolalkylamine catabolic process (GO:0046218)5.40366416
9bile acid biosynthetic process (GO:0006699)5.33967935
10glyoxylate metabolic process (GO:0046487)5.26095544
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.24335244
12kynurenine metabolic process (GO:0070189)5.17773735
13tryptophan metabolic process (GO:0006568)5.07547126
14cysteine metabolic process (GO:0006534)5.03142427
15urea cycle (GO:0000050)4.79809966
16urea metabolic process (GO:0019627)4.79809966
17sulfur amino acid catabolic process (GO:0000098)4.75414958
18high-density lipoprotein particle remodeling (GO:0034375)4.68151518
19alpha-linolenic acid metabolic process (GO:0036109)4.67578471
20lysine metabolic process (GO:0006553)4.64347318
21lysine catabolic process (GO:0006554)4.64347318
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.55984011
23cellular ketone body metabolic process (GO:0046950)4.55947623
24aromatic amino acid family metabolic process (GO:0009072)4.53981255
25nitrogen cycle metabolic process (GO:0071941)4.53685695
26bile acid metabolic process (GO:0008206)4.48378519
27imidazole-containing compound metabolic process (GO:0052803)4.43842073
28negative regulation of fibrinolysis (GO:0051918)4.37952040
29coenzyme catabolic process (GO:0009109)4.35509017
30complement activation, alternative pathway (GO:0006957)4.33911340
31serine family amino acid catabolic process (GO:0009071)4.33828160
32tyrosine metabolic process (GO:0006570)4.33775686
33alpha-amino acid catabolic process (GO:1901606)4.33216306
34regulation of fibrinolysis (GO:0051917)4.30860845
35peptidyl-glutamic acid carboxylation (GO:0017187)4.28046457
36protein carboxylation (GO:0018214)4.28046457
37regulation of protein activation cascade (GO:2000257)4.24766620
38homocysteine metabolic process (GO:0050667)4.19441524
39amino-acid betaine metabolic process (GO:0006577)4.16089518
40regulation of cholesterol esterification (GO:0010872)4.15008084
41regulation of triglyceride catabolic process (GO:0010896)4.12096518
42reverse cholesterol transport (GO:0043691)4.05928334
43cellular amino acid catabolic process (GO:0009063)4.05573164
44acylglycerol homeostasis (GO:0055090)4.04622917
45triglyceride homeostasis (GO:0070328)4.04622917
46glutamate metabolic process (GO:0006536)4.01851899
47protein-lipid complex remodeling (GO:0034368)3.98290258
48macromolecular complex remodeling (GO:0034367)3.98290258
49plasma lipoprotein particle remodeling (GO:0034369)3.98290258
50regulation of complement activation (GO:0030449)3.96284367
51ketone body metabolic process (GO:1902224)3.93707904
52indolalkylamine metabolic process (GO:0006586)3.91331962
53aldehyde catabolic process (GO:0046185)3.85610944
54short-chain fatty acid metabolic process (GO:0046459)3.82012560
55aspartate family amino acid catabolic process (GO:0009068)3.81864074
56phospholipid efflux (GO:0033700)3.81377994
57cellular modified amino acid catabolic process (GO:0042219)3.79944030
58amine catabolic process (GO:0009310)3.79194242
59cellular biogenic amine catabolic process (GO:0042402)3.79194242
60bile acid and bile salt transport (GO:0015721)3.78557050
61drug catabolic process (GO:0042737)3.76628955
62cofactor catabolic process (GO:0051187)3.73829385
63drug transmembrane transport (GO:0006855)3.72845536
64behavioral response to nicotine (GO:0035095)3.69177709
65acetyl-CoA metabolic process (GO:0006084)3.67823815
66negative regulation of sterol transport (GO:0032372)3.67144498
67negative regulation of cholesterol transport (GO:0032375)3.67144498
68benzene-containing compound metabolic process (GO:0042537)3.65368578
69organic acid catabolic process (GO:0016054)3.63570903
70carboxylic acid catabolic process (GO:0046395)3.63570903
71serine family amino acid metabolic process (GO:0009069)3.63055303
72cholesterol efflux (GO:0033344)3.58853788
73plasma lipoprotein particle clearance (GO:0034381)3.58427941
74cellular glucuronidation (GO:0052695)3.58373804
75arginine metabolic process (GO:0006525)3.55384749
76ethanol oxidation (GO:0006069)3.55258501
77regulation of bile acid biosynthetic process (GO:0070857)3.52577654
78fatty acid beta-oxidation (GO:0006635)3.45406500
79monocarboxylic acid catabolic process (GO:0072329)3.45010361
80dicarboxylic acid biosynthetic process (GO:0043650)3.44881360
81fatty acid catabolic process (GO:0009062)3.41365487
82membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.39409013
83fatty acid oxidation (GO:0019395)3.38788437
84glycine metabolic process (GO:0006544)3.38091913
85exogenous drug catabolic process (GO:0042738)3.37917726
86urate metabolic process (GO:0046415)3.37209137
87serine family amino acid biosynthetic process (GO:0009070)3.35315465
882-oxoglutarate metabolic process (GO:0006103)3.33204542
89lipid oxidation (GO:0034440)3.32513896
90glucuronate metabolic process (GO:0019585)3.31594447
91uronic acid metabolic process (GO:0006063)3.31594447
92low-density lipoprotein particle remodeling (GO:0034374)3.29020045
93plasma lipoprotein particle assembly (GO:0034377)3.26958003
94positive regulation of lipoprotein lipase activity (GO:0051006)3.21302817
95positive regulation of triglyceride lipase activity (GO:0061365)3.21302817
96drug metabolic process (GO:0017144)3.21197830
97NAD biosynthetic process (GO:0009435)3.18061022
98very long-chain fatty acid metabolic process (GO:0000038)3.16796108
99carnitine metabolic process (GO:0009437)3.16232015
100branched-chain amino acid catabolic process (GO:0009083)3.15103244
101cholesterol homeostasis (GO:0042632)3.13963810
102nicotinamide nucleotide biosynthetic process (GO:0019359)3.13657387
103epoxygenase P450 pathway (GO:0019373)3.12565565
104protoporphyrinogen IX metabolic process (GO:0046501)3.05147987
105gamma-aminobutyric acid transport (GO:0015812)3.02890170
106alkaloid metabolic process (GO:0009820)3.02054218
107protoporphyrinogen IX biosynthetic process (GO:0006782)2.96599439
108oxygen transport (GO:0015671)2.92587584
109synaptic vesicle maturation (GO:0016188)2.92341702
110regulation of synapse structural plasticity (GO:0051823)2.89258264
111response to misfolded protein (GO:0051788)2.82890377
112positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.74994743
113hydrogen peroxide biosynthetic process (GO:0050665)2.72109644
114neuronal action potential propagation (GO:0019227)2.68335880
115dendritic spine morphogenesis (GO:0060997)2.65987131
116pyrimidine nucleobase catabolic process (GO:0006208)2.64582167
117alanine transport (GO:0032328)2.61434953
118oxidative demethylation (GO:0070989)2.60593713
119heme metabolic process (GO:0042168)2.59849461
120disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.57971131
121killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.57971131
122porphyrin-containing compound metabolic process (GO:0006778)2.57518850
123synaptic vesicle exocytosis (GO:0016079)2.54731326
124positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.53957983
125energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.53787771
126ATP hydrolysis coupled proton transport (GO:0015991)2.53787771
127gas transport (GO:0015669)2.52498434
128neurotransmitter catabolic process (GO:0042135)2.52164196
129neuromuscular process controlling posture (GO:0050884)2.47403372
130tetrapyrrole biosynthetic process (GO:0033014)2.47099855
131reactive oxygen species biosynthetic process (GO:1903409)2.46816496
132creatine metabolic process (GO:0006600)2.46389198
133positive regulation of synapse maturation (GO:0090129)2.43795275
134omega-hydroxylase P450 pathway (GO:0097267)2.42896945
135porphyrin-containing compound biosynthetic process (GO:0006779)2.42764981
136heme biosynthetic process (GO:0006783)2.41243270
137positive regulation of fatty acid transport (GO:2000193)2.39117511
138response to dietary excess (GO:0002021)2.37802204
139neuronal ion channel clustering (GO:0045161)2.36536800
140phenylpropanoid metabolic process (GO:0009698)2.35672552
141regulation of sequestering of triglyceride (GO:0010889)2.35518630
142primary amino compound metabolic process (GO:1901160)2.35212885
143negative regulation of cAMP-mediated signaling (GO:0043951)2.35135710
144membrane depolarization during action potential (GO:0086010)2.31840777
145iron coordination entity transport (GO:1901678)2.31396229
146regulation of hydrogen peroxide metabolic process (GO:0010310)2.31084712
147ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.30788972
148neurotransmitter secretion (GO:0007269)2.29134865
149glutamate secretion (GO:0014047)2.26167501
150positive regulation of triglyceride metabolic process (GO:0090208)2.23864422
151positive regulation of potassium ion transmembrane transport (GO:1901381)2.22917202
152regulation of synapse maturation (GO:0090128)2.22140425
153dopamine transport (GO:0015872)2.21738720
154positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.21344399
155nucleobase catabolic process (GO:0046113)2.21130676
156positive regulation of sodium ion transmembrane transport (GO:1902307)2.21060502
157macroautophagy (GO:0016236)2.20953664
158positive regulation of mitochondrial fission (GO:0090141)2.19910030
159neurotransmitter metabolic process (GO:0042133)2.19487290
160synaptic transmission, cholinergic (GO:0007271)2.19313390
161hemoglobin metabolic process (GO:0020027)2.18945936
162ethanol metabolic process (GO:0006067)2.17399584
163regulation of synaptic vesicle transport (GO:1902803)2.16237353
164regulation of neurotransmitter levels (GO:0001505)2.13432121
165regulation of triglyceride metabolic process (GO:0090207)2.12832040
166serotonin metabolic process (GO:0042428)2.11950703
167viral protein processing (GO:0019082)2.10531716

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.62041680
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.82843803
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.76836245
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.68682773
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.28689270
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.62690110
7EZH2_22144423_ChIP-Seq_EOC_Human4.51964175
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.22770898
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.13079314
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.37329550
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.24621599
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.59134879
13DROSHA_22980978_ChIP-Seq_HELA_Human2.20008334
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.01283694
15JARID2_20075857_ChIP-Seq_MESCs_Mouse1.74012435
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73484280
17DNAJC2_21179169_ChIP-ChIP_NT2_Human1.71660745
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.71051792
19ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.70677073
20HTT_18923047_ChIP-ChIP_STHdh_Human1.70100309
21TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.68945447
22BCL6_27268052_Chip-Seq_Bcells_Human1.65808917
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62403884
24CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.60965971
25P68_20966046_ChIP-Seq_HELA_Human1.54060067
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53403121
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53215975
28LXR_22292898_ChIP-Seq_THP-1_Human1.49278062
29ELF1_20517297_ChIP-Seq_JURKAT_Human1.44733092
30TAF15_26573619_Chip-Seq_HEK293_Human1.38693560
31YY1_22570637_ChIP-Seq_MALME-3M_Human1.38680201
32VDR_22108803_ChIP-Seq_LS180_Human1.38601105
33GATA1_22025678_ChIP-Seq_K562_Human1.36047163
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35530752
35* SA1_27219007_Chip-Seq_Bcells_Human1.34328978
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.33664170
37SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.33607501
38E2F1_20622854_ChIP-Seq_HELA_Human1.32428749
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32000502
40GATA1_19941826_ChIP-Seq_K562_Human1.31879123
41BCOR_27268052_Chip-Seq_Bcells_Human1.30104021
42* FOXA2_19822575_ChIP-Seq_HepG2_Human1.29482623
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29478668
44ERA_21632823_ChIP-Seq_H3396_Human1.29019361
45PHF8_20622854_ChIP-Seq_HELA_Human1.29013357
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.26283839
47CTCF_20526341_ChIP-Seq_ESCs_Human1.25616748
48* GATA1_19941827_ChIP-Seq_MEL_Mouse1.25613699
49RARB_27405468_Chip-Seq_BRAIN_Mouse1.24546779
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.22528279
51OCT4_19829295_ChIP-Seq_ESCs_Human1.22262711
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.22140595
53EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19926512
54SMC4_20622854_ChIP-Seq_HELA_Human1.19730756
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18243945
56GBX2_23144817_ChIP-Seq_PC3_Human1.17758052
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17259497
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.16898641
59NANOG_20526341_ChIP-Seq_ESCs_Human1.13620658
60* HNF4A_19822575_ChIP-Seq_HepG2_Human1.13487589
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09032134
62EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09019531
63RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09019531
64* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08929320
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08801563
66RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08696104
67RAC3_21632823_ChIP-Seq_H3396_Human1.08090385
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.07506322
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06776203
70RXRA_24833708_ChIP-Seq_LIVER_Mouse1.05843370
71MYC_19829295_ChIP-Seq_ESCs_Human1.04184169
72* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02525466
73STAT1_20625510_ChIP-Seq_HELA_Human1.02365584
74RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.01262392
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00139061
76SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00118252
77* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99741396
78KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.98863850
79SOX2_21211035_ChIP-Seq_LN229_Human0.98779701
80SA1_27219007_Chip-Seq_ERYTHROID_Human0.97824722
81FOXH1_21741376_ChIP-Seq_ESCs_Human0.97319366
82EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97273582
83RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95370671
84MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95157869
85PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93552909
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92193255
87* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91346346
88* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90854782
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89229508
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88360189
91* KDM2B_26808549_Chip-Seq_K562_Human0.87959557
92SPI1_20517297_ChIP-Seq_HL60_Human0.87919171
93E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.87645572
94P300_27268052_Chip-Seq_Bcells_Human0.87374944
95RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86930016
96ERG_21242973_ChIP-ChIP_JURKAT_Human0.86406970
97CTCF_21964334_ChIP-Seq_BJAB-B_Human0.86052328
98KAP1_22055183_ChIP-Seq_ESCs_Mouse0.85757346
99TP63_22573176_ChIP-Seq_HFKS_Human0.83465330
100CLOCK_20551151_ChIP-Seq_293T_Human0.82371806
101AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81683654
102* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.81426637
103REST_21632747_ChIP-Seq_MESCs_Mouse0.80684854
104EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.79386821
105* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.78986533
106* REST_18959480_ChIP-ChIP_MESCs_Mouse0.77996068
107SOX2_27498859_Chip-Seq_STOMACH_Mouse0.76970226
108STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.76364983
109MYC_19915707_ChIP-ChIP_AK7_Human0.76148699
110SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75744735
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75555486
112NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75196740
113NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75196740
114GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.74949415
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74553070
116ETV2_25802403_ChIP-Seq_MESCs_Mouse0.73905769
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73287021
118FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.73143721
119BCAT_22108803_ChIP-Seq_LS180_Human0.73092925
120RARA_24833708_ChIP-Seq_LIVER_Mouse0.71769881
121NCOR_22424771_ChIP-Seq_293T_Human0.70769296
122AR_20517297_ChIP-Seq_VCAP_Human0.70756055
123BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69408998
124ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.69321642
125MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.69279727
126GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.68960023
127TAF2_19829295_ChIP-Seq_ESCs_Human0.68694433
128CTBP1_25329375_ChIP-Seq_LNCAP_Human0.68590922
129ERG_20517297_ChIP-Seq_VCAP_Human0.68344236
130PIAS1_25552417_ChIP-Seq_VCAP_Human0.67294846
131* STAT1_17558387_ChIP-Seq_HELA_Human0.66906584
132MTF2_20144788_ChIP-Seq_MESCs_Mouse0.66330087
133P53_21459846_ChIP-Seq_SAOS-2_Human0.65758985
134OCT4_20526341_ChIP-Seq_ESCs_Human0.65648494
135RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.65437265
136CTBP2_25329375_ChIP-Seq_LNCAP_Human0.64982035
137CBP_21632823_ChIP-Seq_H3396_Human0.64017065
138CTCF_27219007_Chip-Seq_Bcells_Human0.62872661
139NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.62594747
140EGR1_19032775_ChIP-ChIP_M12_Human0.62075446
141CBP_20019798_ChIP-Seq_JUKART_Human0.61750600
142IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.61750600
143SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.61062823
144SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.60864480
145AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.58288823
146ESET_19884257_ChIP-Seq_ESCs_Mouse0.57919729
147NANOG_19829295_ChIP-Seq_ESCs_Human0.56758633
148SOX2_19829295_ChIP-Seq_ESCs_Human0.56758633
149PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.56732497
150ZFP57_27257070_Chip-Seq_ESCs_Mouse0.56587223
151GATA4_25053715_ChIP-Seq_YYC3_Human0.56352102
152LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.55686747
153RARB_24833708_ChIP-Seq_LIVER_Mouse0.54831808
154* CEBPB_22108803_ChIP-Seq_LS180_Human0.54433691
155SMAD4_21741376_ChIP-Seq_EPCs_Human0.53847303
156FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53584071
157EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.53537669
158KDM2B_26808549_Chip-Seq_REH_Human0.53472262
159SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.52468778
160ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.52461519
161SUZ12_27294783_Chip-Seq_ESCs_Mouse0.52271395
162P300_19829295_ChIP-Seq_ESCs_Human0.51230171
163PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.51113195
164P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.51041786
165FOXH1_21741376_ChIP-Seq_EPCs_Human0.50705327
166CRX_20693478_ChIP-Seq_RETINA_Mouse0.50436626

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.42770369
2MP0005360_urolithiasis6.93270042
3MP0005085_abnormal_gallbladder_physiolo5.71698148
4MP0005365_abnormal_bile_salt5.49534314
5MP0008875_abnormal_xenobiotic_pharmacok4.75021040
6MP0003806_abnormal_nucleotide_metabolis3.97371768
7MP0003195_calcinosis3.31667674
8MP0003252_abnormal_bile_duct3.27433138
9MP0010329_abnormal_lipoprotein_level3.12192150
10MP0005332_abnormal_amino_acid2.94409533
11MP0005083_abnormal_biliary_tract2.92346667
12MP0009840_abnormal_foam_cell2.56421768
13MP0001666_abnormal_nutrient_absorption2.47288374
14MP0003646_muscle_fatigue2.29182965
15MP0004859_abnormal_synaptic_plasticity2.17585469
16MP0002876_abnormal_thyroid_physiology2.11166990
17MP0004019_abnormal_vitamin_homeostasis2.10286057
18MP0002118_abnormal_lipid_homeostasis2.04946009
19MP0004145_abnormal_muscle_electrophysio1.97235063
20MP0001764_abnormal_homeostasis1.92926210
21MP0002138_abnormal_hepatobiliary_system1.92482511
22MP0005423_abnormal_somatic_nervous1.89370404
23MP0003191_abnormal_cellular_cholesterol1.85720526
24MP0003868_abnormal_feces_composition1.81391526
25MP0000609_abnormal_liver_physiology1.79441351
26MP0003635_abnormal_synaptic_transmissio1.72337152
27MP0005319_abnormal_enzyme/_coenzyme1.69360317
28MP0005584_abnormal_enzyme/coenzyme_acti1.65089863
29MP0001486_abnormal_startle_reflex1.54936756
30MP0001905_abnormal_dopamine_level1.53911505
31MP0002063_abnormal_learning/memory/cond1.51934016
32MP0009643_abnormal_urine_homeostasis1.49363802
33MP0003787_abnormal_imprinting1.48780601
34MP0003656_abnormal_erythrocyte_physiolo1.46731369
35MP0002653_abnormal_ependyma_morphology1.43851207
36MP0002254_reproductive_system_inflammat1.41154043
37MP0006036_abnormal_mitochondrial_physio1.40284564
38MP0003878_abnormal_ear_physiology1.39190796
39MP0005377_hearing/vestibular/ear_phenot1.39190796
40MP0002572_abnormal_emotion/affect_behav1.38563737
41MP0005636_abnormal_mineral_homeostasis1.35437897
42MP0004043_abnormal_pH_regulation1.34829168
43MP0002734_abnormal_mechanical_nocicepti1.32941330
44MP0009697_abnormal_copulation1.30628402
45MP0001986_abnormal_taste_sensitivity1.29650982
46MP0005167_abnormal_blood-brain_barrier1.28515448
47MP0002837_dystrophic_cardiac_calcinosis1.28024360
48MP0004885_abnormal_endolymph1.27082932
49MP0003186_abnormal_redox_activity1.24009604
50MP0001970_abnormal_pain_threshold1.21886203
51MP0005451_abnormal_body_composition1.20609647
52MP0002638_abnormal_pupillary_reflex1.20460373
53MP0005535_abnormal_body_temperature1.19335754
54MP0003329_amyloid_beta_deposits1.17952378
55MP0000604_amyloidosis1.16326908
56MP0002822_catalepsy1.13741101
57MP0004742_abnormal_vestibular_system1.13107842
58MP0002067_abnormal_sensory_capabilities1.12289457
59MP0002332_abnormal_exercise_endurance1.11075820
60MP0005647_abnormal_sex_gland1.10736531
61MP0003137_abnormal_impulse_conducting1.08369301
62MP0002078_abnormal_glucose_homeostasis1.05589429
63MP0000749_muscle_degeneration1.05283653
64MP0003172_abnormal_lysosome_physiology1.00856222
65MP0005084_abnormal_gallbladder_morpholo0.98899976
66MP0002557_abnormal_social/conspecific_i0.98610835
67MP0003011_delayed_dark_adaptation0.97627433
68MP0004924_abnormal_behavior0.95959570
69MP0005386_behavior/neurological_phenoty0.95959570
70MP0001529_abnormal_vocalization0.95864053
71MP0008961_abnormal_basal_metabolism0.95077286
72MP0003122_maternal_imprinting0.94258668
73MP0001485_abnormal_pinna_reflex0.88898358
74MP0003123_paternal_imprinting0.88855961
75MP0006035_abnormal_mitochondrial_morpho0.88836083
76MP0005670_abnormal_white_adipose0.88017181
77MP0001756_abnormal_urination0.87287518
78MP0003631_nervous_system_phenotype0.86600265
79MP0009764_decreased_sensitivity_to0.85857934
80MP0000598_abnormal_liver_morphology0.85378771
81MP0009642_abnormal_blood_homeostasis0.85346172
82MP0008569_lethality_at_weaning0.84810126
83MP0005376_homeostasis/metabolism_phenot0.84200447
84MP0000751_myopathy0.83933499
85MP0002066_abnormal_motor_capabilities/c0.82937333
86MP0003879_abnormal_hair_cell0.82427313
87MP0005448_abnormal_energy_balance0.81733515
88MP0002971_abnormal_brown_adipose0.81694503
89MP0002735_abnormal_chemical_nociception0.81351600
90MP0004147_increased_porphyrin_level0.79575294
91MP0005379_endocrine/exocrine_gland_phen0.79291472
92MP0008872_abnormal_physiological_respon0.78302477
93MP0001765_abnormal_ion_homeostasis0.77965779
94MP0005410_abnormal_fertilization0.74998714
95MP0005334_abnormal_fat_pad0.74710737
96MP0005266_abnormal_metabolism0.74458846
97MP0005220_abnormal_exocrine_pancreas0.74360508
98MP0008469_abnormal_protein_level0.70851235
99MP0003690_abnormal_glial_cell0.70703330
100MP0009763_increased_sensitivity_to0.70691018
101MP0004130_abnormal_muscle_cell0.70539562
102MP0009765_abnormal_xenobiotic_induced0.69347126
103MP0003953_abnormal_hormone_level0.66560347
104MP0001661_extended_life_span0.66457441
105MP0008874_decreased_physiological_sensi0.66301000
106MP0002736_abnormal_nociception_after0.65967655
107MP0003638_abnormal_response/metabolism_0.64852493
108MP0000230_abnormal_systemic_arterial0.64789979
109MP0006276_abnormal_autonomic_nervous0.64692626
110MP0001984_abnormal_olfaction0.64005899
111MP0005645_abnormal_hypothalamus_physiol0.63399389
112MP0000639_abnormal_adrenal_gland0.62636239
113MP0004142_abnormal_muscle_tone0.61584609
114MP0001968_abnormal_touch/_nociception0.59367933
115MP0003959_abnormal_lean_body0.58943487
116MP0005408_hypopigmentation0.57770735
117MP0005551_abnormal_eye_electrophysiolog0.57485092
118MP0001501_abnormal_sleep_pattern0.55808821
119MP0005646_abnormal_pituitary_gland0.55181698
120MP0002090_abnormal_vision0.52971672
121MP0002272_abnormal_nervous_system0.51616707
122MP0009745_abnormal_behavioral_response0.51076508
123MP0002069_abnormal_eating/drinking_beha0.50035835
124MP0002136_abnormal_kidney_physiology0.49760462
125MP0002064_seizures0.49647435
126MP0004270_analgesia0.47946758
127MP0002909_abnormal_adrenal_gland0.47015552
128MP0003880_abnormal_central_pattern0.45530453
129MP0001440_abnormal_grooming_behavior0.45382242
130MP0002733_abnormal_thermal_nociception0.44458986
131MP0001502_abnormal_circadian_rhythm0.44005578
132MP0003075_altered_response_to0.43833776
133MP0002229_neurodegeneration0.43715405
134MP0003633_abnormal_nervous_system0.42913517
135MP0001944_abnormal_pancreas_morphology0.42434603
136MP0000538_abnormal_urinary_bladder0.41160774
137MP0009046_muscle_twitch0.40955778
138MP0002928_abnormal_bile_duct0.40937095

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.82404938
2Intrahepatic cholestasis (HP:0001406)6.04957218
3Deep venous thrombosis (HP:0002625)5.49662680
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.29914051
5Prolonged partial thromboplastin time (HP:0003645)5.23114866
6Hypobetalipoproteinemia (HP:0003563)5.14963139
7Xanthomatosis (HP:0000991)5.06958580
8Hyperlipoproteinemia (HP:0010980)4.48263907
9Ketosis (HP:0001946)4.34511706
10Hyperammonemia (HP:0001987)4.17930504
11Complement deficiency (HP:0004431)4.07518948
12Abnormality of the heme biosynthetic pathway (HP:0010472)3.88154073
13Abnormality of glutamine family amino acid metabolism (HP:0010902)3.86552451
14Hypoglycemic coma (HP:0001325)3.82199905
15Hyperglycinuria (HP:0003108)3.80987216
16Hyperglycinemia (HP:0002154)3.80732234
17Abnormality of aspartate family amino acid metabolism (HP:0010899)3.79848665
18Hypolipoproteinemia (HP:0010981)3.77659742
19Abnormality of glycine metabolism (HP:0010895)3.69339538
20Abnormality of serine family amino acid metabolism (HP:0010894)3.69339538
21Myokymia (HP:0002411)3.65459944
22Ketoacidosis (HP:0001993)3.65127485
23Abnormality of methionine metabolism (HP:0010901)3.62519149
24Fat malabsorption (HP:0002630)3.59831805
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.54787276
26Joint hemorrhage (HP:0005261)3.53463065
27Epidermoid cyst (HP:0200040)3.48917775
28Abnormality of fatty-acid metabolism (HP:0004359)3.46652920
29Conjugated hyperbilirubinemia (HP:0002908)3.43344197
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.43071383
31Abnormality of the common coagulation pathway (HP:0010990)3.33472314
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.32118660
33Hypoalphalipoproteinemia (HP:0003233)3.21237038
34Cerebral edema (HP:0002181)3.20242810
35Abnormality of the intrinsic pathway (HP:0010989)3.20146435
36Gout (HP:0001997)3.15760764
37Hyperbilirubinemia (HP:0002904)3.15632033
38Hypochromic anemia (HP:0001931)3.01570229
39Metabolic acidosis (HP:0001942)2.97868792
40Lethargy (HP:0001254)2.92928503
41Abnormality of dicarboxylic acid metabolism (HP:0010995)2.91099104
42Dicarboxylic aciduria (HP:0003215)2.91099104
43Abnormal gallbladder morphology (HP:0012437)2.90498416
44Abnormal gallbladder physiology (HP:0012438)2.86596245
45Cholecystitis (HP:0001082)2.86596245
46Delayed CNS myelination (HP:0002188)2.84380348
47Abnormality of purine metabolism (HP:0004352)2.83042548
48Abnormality of complement system (HP:0005339)2.83013460
49Cholelithiasis (HP:0001081)2.82864749
50Abnormality of serum amino acid levels (HP:0003112)2.80300492
51Polyphagia (HP:0002591)2.79742028
52Abnormality of nucleobase metabolism (HP:0010932)2.79319958
53Steatorrhea (HP:0002570)2.73441314
54Hypoglycemic seizures (HP:0002173)2.72778171
55Abnormality of pyrimidine metabolism (HP:0004353)2.71874779
56Focal motor seizures (HP:0011153)2.61593768
57Hypercholesterolemia (HP:0003124)2.60525192
58Acute encephalopathy (HP:0006846)2.60234793
59Visual hallucinations (HP:0002367)2.60083535
60Postural instability (HP:0002172)2.59864467
61Generalized aminoaciduria (HP:0002909)2.59503367
62Vomiting (HP:0002013)2.44163295
63Hyperinsulinemic hypoglycemia (HP:0000825)2.41158498
64Irritability (HP:0000737)2.39277677
65Acanthocytosis (HP:0001927)2.37636424
66Limb dystonia (HP:0002451)2.37552938
67Brushfield spots (HP:0001088)2.36662398
68Hepatic necrosis (HP:0002605)2.35908311
69Agitation (HP:0000713)2.32493550
70Abnormality of the gallbladder (HP:0005264)2.29844861
71Skin nodule (HP:0200036)2.29462595
72Recurrent gram-negative bacterial infections (HP:0005420)2.28822149
73Alkalosis (HP:0001948)2.26501243
74Sensorimotor neuropathy (HP:0007141)2.24442675
75Vascular calcification (HP:0004934)2.22306026
76Malnutrition (HP:0004395)2.21784466
77Spontaneous abortion (HP:0005268)2.21595934
78Abnormality of urine glucose concentration (HP:0011016)2.20248719
79Glycosuria (HP:0003076)2.20248719
80Epileptic encephalopathy (HP:0200134)2.19688139
81Mitochondrial inheritance (HP:0001427)2.18251623
82Ventricular fibrillation (HP:0001663)2.17351279
83Febrile seizures (HP:0002373)2.17319951
84Hyperuricemia (HP:0002149)2.16750380
85Increased purine levels (HP:0004368)2.16750380
86Late onset (HP:0003584)2.16289002
87Hepatocellular carcinoma (HP:0001402)2.14956213
88Exercise-induced myalgia (HP:0003738)2.13299995
89Neonatal onset (HP:0003623)2.12834786
90Cerebral palsy (HP:0100021)2.12480748
91Proximal tubulopathy (HP:0000114)2.12390061
92Focal seizures (HP:0007359)2.11996156
93Poikilocytosis (HP:0004447)2.11780250
94Enlarged kidneys (HP:0000105)2.11662155
95Symptomatic seizures (HP:0011145)2.11203047
96Abnormal eating behavior (HP:0100738)2.10242255
97Microcytic anemia (HP:0001935)2.10241138
98Hypochromic microcytic anemia (HP:0004840)2.07634441
99Abnormal mitochondria in muscle tissue (HP:0008316)2.06301516
100Osteomalacia (HP:0002749)2.05968321
101Opisthotonus (HP:0002179)2.02906877
102Abnormality of transition element cation homeostasis (HP:0011030)2.02677010
103Confusion (HP:0001289)2.01861686
104Systemic lupus erythematosus (HP:0002725)2.01541771
105Polyuria (HP:0000103)2.01413421
106Pancreatitis (HP:0001733)1.98827050
107Abnormality of proline metabolism (HP:0010907)1.98105656
108Hydroxyprolinuria (HP:0003080)1.98105656
109Anxiety (HP:0000739)1.97876079
110Methylmalonic aciduria (HP:0012120)1.97088842
111Acute necrotizing encephalopathy (HP:0006965)1.96837846
112Hyperventilation (HP:0002883)1.94912327
113Abnormality of midbrain morphology (HP:0002418)1.93991777
114Molar tooth sign on MRI (HP:0002419)1.93991777
115Increased intramyocellular lipid droplets (HP:0012240)1.92923113
116Syncope (HP:0001279)1.92546455
117Acute hepatic failure (HP:0006554)1.92058863
118Abnormality of dental color (HP:0011073)1.91863681
119Reticulocytosis (HP:0001923)1.91759833
120Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91469216
121Abnormality of alanine metabolism (HP:0010916)1.91469216
122Hyperalaninemia (HP:0003348)1.91469216
123Increased serum pyruvate (HP:0003542)1.91182499
124Abnormality of glycolysis (HP:0004366)1.91182499
125Abnormality of iron homeostasis (HP:0011031)1.90748319
126Lactic acidosis (HP:0003128)1.90458931
127Increased serum ferritin (HP:0003281)1.90115949
128Abnormal urine output (HP:0012590)1.89567777
129Status epilepticus (HP:0002133)1.89211411
130Mitral stenosis (HP:0001718)1.89191967
131Diplopia (HP:0000651)1.88910107
132Abnormality of binocular vision (HP:0011514)1.88910107
133Hepatocellular necrosis (HP:0001404)1.88821021
134Increased muscle lipid content (HP:0009058)1.88250961
135Abnormality of vitamin metabolism (HP:0100508)1.88175123
136Toxemia of pregnancy (HP:0100603)1.87551758
137Cardiovascular calcification (HP:0011915)1.87318455
138Abnormal rod and cone electroretinograms (HP:0008323)1.85881040
139Rickets (HP:0002748)1.85432298
140Muscle fiber inclusion bodies (HP:0100299)1.83451704
141Progressive macrocephaly (HP:0004481)1.83260089
142Abnormality of magnesium homeostasis (HP:0004921)1.82538881
143Abnormality of renal resorption (HP:0011038)1.81978022
144Glomerulonephritis (HP:0000099)1.80954880
145Hypomagnesemia (HP:0002917)1.80180081
146Mutism (HP:0002300)1.79556286
147Retinal atrophy (HP:0001105)1.78903512
148Myoglobinuria (HP:0002913)1.78791030
149Amelogenesis imperfecta (HP:0000705)1.77735327
150Congenital stationary night blindness (HP:0007642)1.77418482
151Absent rod-and cone-mediated responses on ERG (HP:0007688)1.75289491
152Myopathic facies (HP:0002058)1.74843716
153Increased CSF lactate (HP:0002490)1.74463514
154Muscle fiber splitting (HP:0003555)1.74233242
155Decreased central vision (HP:0007663)1.73456853
156Absence seizures (HP:0002121)1.72420915
157Abnormality of liposaccharide metabolism (HP:0010968)1.72369627
158Abnormality of glycosphingolipid metabolism (HP:0004343)1.72369627
159Abnormality of glycolipid metabolism (HP:0010969)1.72369627
160Abnormal EKG (HP:0003115)1.71472387
161Prolonged QT interval (HP:0001657)1.70841563
162Abnormal hemoglobin (HP:0011902)1.70705848
163Generalized tonic-clonic seizures (HP:0002069)1.68840078
164Abnormality of renal excretion (HP:0011036)1.68561413
165Progressive cerebellar ataxia (HP:0002073)1.68509144
166Neurofibrillary tangles (HP:0002185)1.68346149
167Focal dystonia (HP:0004373)1.66584900
168Paralysis (HP:0003470)1.66471610
169Supranuclear gaze palsy (HP:0000605)1.65088593
170Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.64926386
171Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.63916935
172Abnormal drinking behavior (HP:0030082)1.62965207
173Polydipsia (HP:0001959)1.62965207

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.42038676
2INSRR3.30650434
3ERN12.82095918
4NTRK22.61418182
5FGFR42.59905761
6MAP2K42.50630542
7WNK42.39312361
8DAPK22.34733753
9MAPK152.20606379
10SIK12.20534955
11PDK32.19714565
12PDK42.19714565
13WNK31.99853029
14ERBB41.99486121
15OXSR11.96033992
16MARK11.95773202
17PINK11.85875629
18EPHA41.77018524
19PIK3CG1.73279489
20SIK21.71091754
21TAOK31.70349589
22TLK11.69771631
23ADRBK21.68598090
24RIPK41.61848125
25CAMKK11.60754836
26ARAF1.60069108
27MAP3K41.52110898
28CASK1.43990162
29CAMKK21.43475627
30GRK51.43111022
31TAOK11.37068449
32MAP4K11.35146057
33STK391.33013119
34MST1R1.31536777
35MAP2K71.30804930
36MUSK1.27528588
37CAMK2G1.24774864
38MAP3K121.23866927
39PAK61.23374372
40PDK21.22336929
41TNK21.21877044
42MAPK131.20615254
43CAMK11.20578060
44NME11.15370511
45NTRK31.14961961
46SGK4941.12622599
47SGK2231.12622599
48BLK1.12434246
49MAP4K21.08570665
50MAP2K31.07286171
51STK161.05926085
52PRKCG1.05326262
53NTRK11.04671870
54DYRK1B1.04528880
55TESK21.04433189
56MAPK111.04288881
57FES1.03377175
58ABL20.99960097
59GRK60.97448251
60CDK190.96790709
61DYRK20.90229670
62PRKCZ0.90225618
63PRKAA20.89564899
64MYLK0.87139552
65STK110.86923856
66FRK0.86149612
67SYK0.85342182
68UHMK10.84039577
69FLT30.82685017
70CAMK2A0.82581863
71LIMK10.81628761
72CAMK40.80825090
73MAPKAPK30.79932990
74MAP3K70.78988666
75STK38L0.78889287
76MARK20.78005649
77PTK2B0.77728669
78PRKACG0.77298162
79PDPK10.77109622
80BRAF0.76231036
81GRK70.75834179
82MAP3K140.75780982
83MAP3K30.75699387
84CAMK2B0.75327865
85MAP3K110.73931005
86MAP3K20.73404013
87JAK20.72993628
88MAP2K10.72695165
89TXK0.72099445
90MINK10.71227541
91TRIB30.69977038
92KSR20.69311364
93DAPK10.67565527
94BCR0.66252800
95BMPR20.64588328
96MET0.64088997
97PKN10.63485090
98MAP3K130.63400894
99PRKD20.61783938
100MAP2K60.61004519
101PRKCQ0.59938012
102MAPK40.58900274
103PRKAA10.58664268
104PIM20.58402159
105PRKACA0.57303084
106CAMK2D0.57076087
107DAPK30.56751915
108MAPK120.56207915
109SGK10.55374220
110MAP3K10.54687238
111PDK10.54071654
112PRKCA0.53298900
113AKT30.53224628
114PIK3CA0.53182385
115PRKCH0.53081244
116IRAK10.52935103
117OBSCN0.52355798
118TESK10.51947272
119STK380.51910575
120RPS6KA20.51686865
121ADRBK10.51321161
122PTK20.51283509
123TBK10.50242224
124PRKG10.50018289
125CSNK1G20.49471551
126PAK30.47691438
127SGK20.47409672
128TAOK20.47094893
129MAP3K50.45734552
130EPHB10.44717576
131PRKCE0.42849647
132MAPKAPK50.42470742
133TYK20.42361869
134IRAK20.40092832
135FER0.39390571
136GRK10.37911979
137PRKD30.36789571
138PBK0.36781583
139PTK60.36528498
140PHKG10.36473562
141PHKG20.36473562
142MAP2K20.35849030
143MAPK70.34528666
144DYRK1A0.34510269
145CDK50.33498549

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.99276784
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.44877341
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.86550647
4Nitrogen metabolism_Homo sapiens_hsa009102.78908155
5Arginine biosynthesis_Homo sapiens_hsa002202.70516406
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61697620
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.52778886
8Tryptophan metabolism_Homo sapiens_hsa003802.51066044
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.50995676
10Fatty acid degradation_Homo sapiens_hsa000712.37927097
11Butanoate metabolism_Homo sapiens_hsa006502.31574334
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.30721530
13Propanoate metabolism_Homo sapiens_hsa006402.23802852
14Peroxisome_Homo sapiens_hsa041462.10130912
15Complement and coagulation cascades_Homo sapiens_hsa046102.09657363
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.00097862
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99147903
18Histidine metabolism_Homo sapiens_hsa003401.98845752
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90992662
20Sulfur metabolism_Homo sapiens_hsa009201.80285490
21Fatty acid metabolism_Homo sapiens_hsa012121.78132017
22Chemical carcinogenesis_Homo sapiens_hsa052041.72573915
23* Pyruvate metabolism_Homo sapiens_hsa006201.71145123
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.70241978
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70038788
26PPAR signaling pathway_Homo sapiens_hsa033201.68779666
27Phenylalanine metabolism_Homo sapiens_hsa003601.67886177
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.63166435
29beta-Alanine metabolism_Homo sapiens_hsa004101.60992034
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58938918
31Fatty acid elongation_Homo sapiens_hsa000621.57620559
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55802666
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52111553
34Tyrosine metabolism_Homo sapiens_hsa003501.45671821
35Bile secretion_Homo sapiens_hsa049761.44879579
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.41587136
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.40841042
38Retinol metabolism_Homo sapiens_hsa008301.39984498
39Selenocompound metabolism_Homo sapiens_hsa004501.37601090
40Morphine addiction_Homo sapiens_hsa050321.36925372
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.35299047
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.32965172
43Carbon metabolism_Homo sapiens_hsa012001.29039830
44Caffeine metabolism_Homo sapiens_hsa002321.28794966
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27946621
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.26599033
47Folate biosynthesis_Homo sapiens_hsa007901.22769007
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19985034
49Biosynthesis of amino acids_Homo sapiens_hsa012301.19218909
50Starch and sucrose metabolism_Homo sapiens_hsa005001.18562646
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18026273
52Fat digestion and absorption_Homo sapiens_hsa049751.12677289
53ABC transporters_Homo sapiens_hsa020101.08280647
54Circadian entrainment_Homo sapiens_hsa047131.07789827
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07680263
56Steroid biosynthesis_Homo sapiens_hsa001001.07118075
57Staphylococcus aureus infection_Homo sapiens_hsa051501.06261269
58Phototransduction_Homo sapiens_hsa047441.03427388
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01315006
60Arginine and proline metabolism_Homo sapiens_hsa003301.00536571
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95626116
62Oxidative phosphorylation_Homo sapiens_hsa001900.95435418
63Glutamatergic synapse_Homo sapiens_hsa047240.94386388
64Vitamin B6 metabolism_Homo sapiens_hsa007500.93970069
65Olfactory transduction_Homo sapiens_hsa047400.92737377
66Cocaine addiction_Homo sapiens_hsa050300.91629886
67Vitamin digestion and absorption_Homo sapiens_hsa049770.90788073
68Amphetamine addiction_Homo sapiens_hsa050310.89992105
69Sulfur relay system_Homo sapiens_hsa041220.87688319
70Glycerolipid metabolism_Homo sapiens_hsa005610.77395069
71Dopaminergic synapse_Homo sapiens_hsa047280.74832031
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74682589
73Glutathione metabolism_Homo sapiens_hsa004800.73794149
74Ovarian steroidogenesis_Homo sapiens_hsa049130.72941694
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72254414
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70895982
77Gastric acid secretion_Homo sapiens_hsa049710.67324753
78Parkinsons disease_Homo sapiens_hsa050120.65451828
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64145381
80Serotonergic synapse_Homo sapiens_hsa047260.64095397
81Metabolic pathways_Homo sapiens_hsa011000.62817685
82Oxytocin signaling pathway_Homo sapiens_hsa049210.62392748
83Salivary secretion_Homo sapiens_hsa049700.61917471
84Cholinergic synapse_Homo sapiens_hsa047250.61809605
85Calcium signaling pathway_Homo sapiens_hsa040200.56402088
86Pentose phosphate pathway_Homo sapiens_hsa000300.56073606
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56044914
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53541030
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49144397
90Alzheimers disease_Homo sapiens_hsa050100.48145066
91Taste transduction_Homo sapiens_hsa047420.47865422
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47796644
93Collecting duct acid secretion_Homo sapiens_hsa049660.47542412
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45348915
95Fructose and mannose metabolism_Homo sapiens_hsa000510.44356614
96Linoleic acid metabolism_Homo sapiens_hsa005910.44319064
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43940839
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.43877268
99Fatty acid biosynthesis_Homo sapiens_hsa000610.42634705
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41737942
101Dilated cardiomyopathy_Homo sapiens_hsa054140.40729800
102Lysosome_Homo sapiens_hsa041420.39309806
103Lysine degradation_Homo sapiens_hsa003100.37627774
104Prion diseases_Homo sapiens_hsa050200.29793922
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.29667684
106Galactose metabolism_Homo sapiens_hsa000520.29660963
107Synaptic vesicle cycle_Homo sapiens_hsa047210.27154939
108Huntingtons disease_Homo sapiens_hsa050160.24723452
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22509361
110Glucagon signaling pathway_Homo sapiens_hsa049220.22017404
111Protein export_Homo sapiens_hsa030600.21911625
112GABAergic synapse_Homo sapiens_hsa047270.13454310
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.13033383
114Regulation of autophagy_Homo sapiens_hsa041400.10710338
115One carbon pool by folate_Homo sapiens_hsa006700.10115230
116Cardiac muscle contraction_Homo sapiens_hsa042600.08590207
117Vibrio cholerae infection_Homo sapiens_hsa051100.06479183
118Insulin secretion_Homo sapiens_hsa049110.05754689
119Insulin resistance_Homo sapiens_hsa049310.04675922
120Nicotine addiction_Homo sapiens_hsa050330.01811222
121Thyroid hormone synthesis_Homo sapiens_hsa049180.01677656
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.00974121
123Ether lipid metabolism_Homo sapiens_hsa005650.00301586
124Retrograde endocannabinoid signaling_Homo sapiens_hsa04723-0.0779302
125AMPK signaling pathway_Homo sapiens_hsa04152-0.0758631
126Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0391766
127Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0364691
128Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0015708

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