HAMP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.53084393
2L-phenylalanine catabolic process (GO:0006559)7.53084393
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.25535309
4L-phenylalanine metabolic process (GO:0006558)7.25535309
5aromatic amino acid family catabolic process (GO:0009074)6.81512886
6exogenous drug catabolic process (GO:0042738)6.74542999
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.62044127
8tryptophan catabolic process (GO:0006569)6.21331264
9indole-containing compound catabolic process (GO:0042436)6.21331264
10indolalkylamine catabolic process (GO:0046218)6.21331264
11kynurenine metabolic process (GO:0070189)6.00836383
12high-density lipoprotein particle remodeling (GO:0034375)5.99248173
13tryptophan metabolic process (GO:0006568)5.81967761
14bile acid biosynthetic process (GO:0006699)5.81042257
15negative regulation of fibrinolysis (GO:0051918)5.69615728
16urea metabolic process (GO:0019627)5.68247355
17urea cycle (GO:0000050)5.68247355
18omega-hydroxylase P450 pathway (GO:0097267)5.63309371
19regulation of cholesterol esterification (GO:0010872)5.60821981
20glyoxylate metabolic process (GO:0046487)5.55283960
21regulation of fibrinolysis (GO:0051917)5.42878367
22alpha-linolenic acid metabolic process (GO:0036109)5.39139236
23protein carboxylation (GO:0018214)5.33286698
24peptidyl-glutamic acid carboxylation (GO:0017187)5.33286698
25epoxygenase P450 pathway (GO:0019373)5.30249063
26nitrogen cycle metabolic process (GO:0071941)5.21947225
27regulation of protein activation cascade (GO:2000257)5.20928499
28sulfur amino acid catabolic process (GO:0000098)5.17254271
29complement activation, alternative pathway (GO:0006957)5.16026652
30phospholipid efflux (GO:0033700)5.11771502
31cysteine metabolic process (GO:0006534)5.10419367
32protein-lipid complex remodeling (GO:0034368)5.08848373
33macromolecular complex remodeling (GO:0034367)5.08848373
34plasma lipoprotein particle remodeling (GO:0034369)5.08848373
35regulation of triglyceride catabolic process (GO:0010896)5.08831955
36negative regulation of cholesterol transport (GO:0032375)5.04718378
37negative regulation of sterol transport (GO:0032372)5.04718378
38serine family amino acid catabolic process (GO:0009071)4.99230401
39reverse cholesterol transport (GO:0043691)4.99036742
40bile acid metabolic process (GO:0008206)4.96316239
41aromatic amino acid family metabolic process (GO:0009072)4.95164520
42oxidative demethylation (GO:0070989)4.93961476
43S-adenosylmethionine metabolic process (GO:0046500)4.89809027
44fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.82384746
45regulation of complement activation (GO:0030449)4.80824309
46tyrosine metabolic process (GO:0006570)4.78101339
47plasma lipoprotein particle clearance (GO:0034381)4.63439228
48alpha-amino acid catabolic process (GO:1901606)4.57813160
49triglyceride homeostasis (GO:0070328)4.57630607
50acylglycerol homeostasis (GO:0055090)4.57630607
51homocysteine metabolic process (GO:0050667)4.53648770
52lysine catabolic process (GO:0006554)4.47936960
53lysine metabolic process (GO:0006553)4.47936960
54cholesterol efflux (GO:0033344)4.47689036
55amino-acid betaine metabolic process (GO:0006577)4.41067634
56indolalkylamine metabolic process (GO:0006586)4.37395436
57drug metabolic process (GO:0017144)4.37047038
58coenzyme catabolic process (GO:0009109)4.36837206
59plasma lipoprotein particle assembly (GO:0034377)4.34644370
60cellular biogenic amine catabolic process (GO:0042402)4.31427153
61amine catabolic process (GO:0009310)4.31427153
62benzene-containing compound metabolic process (GO:0042537)4.28679738
63very-low-density lipoprotein particle assembly (GO:0034379)4.26723853
64imidazole-containing compound metabolic process (GO:0052803)4.24393993
65glycine metabolic process (GO:0006544)4.20471228
66cellular amino acid catabolic process (GO:0009063)4.18662052
67bile acid and bile salt transport (GO:0015721)4.17764317
68cellular glucuronidation (GO:0052695)4.16642742
69drug catabolic process (GO:0042737)4.16563793
70heme transport (GO:0015886)4.13873245
71negative regulation of lipase activity (GO:0060192)4.13409804
72cellular ketone body metabolic process (GO:0046950)4.13394263
73low-density lipoprotein particle remodeling (GO:0034374)4.12728794
74glutamate metabolic process (GO:0006536)4.11389938
75arginine metabolic process (GO:0006525)4.06413372
76fibrinolysis (GO:0042730)4.03109475
77behavioral response to nicotine (GO:0035095)4.01641386
78serine family amino acid metabolic process (GO:0009069)4.01158351
79ketone body metabolic process (GO:1902224)4.00723319
80positive regulation of lipid catabolic process (GO:0050996)3.97441105
81dicarboxylic acid biosynthetic process (GO:0043650)3.95200437
82cellular modified amino acid catabolic process (GO:0042219)3.91918516
83aldehyde catabolic process (GO:0046185)3.91203736
84positive regulation of lipoprotein lipase activity (GO:0051006)3.90181726
85positive regulation of triglyceride lipase activity (GO:0061365)3.90181726
86cofactor catabolic process (GO:0051187)3.88171435
87protein-lipid complex assembly (GO:0065005)3.88115154
88acute-phase response (GO:0006953)3.87671466
89ethanol metabolic process (GO:0006067)3.85948807
90ethanol oxidation (GO:0006069)3.85928060
91serine family amino acid biosynthetic process (GO:0009070)3.85880771
92plasma lipoprotein particle organization (GO:0071827)3.84280382
93opsonization (GO:0008228)3.82491007
94blood coagulation, intrinsic pathway (GO:0007597)3.79203257
95alkaloid metabolic process (GO:0009820)3.79137288
96complement activation, classical pathway (GO:0006958)3.71760980
97cholesterol homeostasis (GO:0042632)3.71690151
98uronic acid metabolic process (GO:0006063)3.69637684
99glucuronate metabolic process (GO:0019585)3.69637684
100regulation of bile acid biosynthetic process (GO:0070857)3.68345410
101short-chain fatty acid metabolic process (GO:0046459)3.67478522
102NAD biosynthetic process (GO:0009435)3.66712126
103protein activation cascade (GO:0072376)3.66501750
104positive regulation of fatty acid beta-oxidation (GO:0032000)3.66228505
105sterol homeostasis (GO:0055092)3.65267842
106complement activation (GO:0006956)3.65266875
107organic acid catabolic process (GO:0016054)3.64543571
108carboxylic acid catabolic process (GO:0046395)3.64543571
109phenylpropanoid metabolic process (GO:0009698)3.63843628
110protein-lipid complex subunit organization (GO:0071825)3.60512707
111water-soluble vitamin biosynthetic process (GO:0042364)3.59390353
112flavonoid metabolic process (GO:0009812)3.58540656
113positive regulation of fatty acid transport (GO:2000193)3.25056542
114L-methionine salvage (GO:0071267)3.24922475
115L-methionine biosynthetic process (GO:0071265)3.24922475
116amino acid salvage (GO:0043102)3.24922475
117indole-containing compound metabolic process (GO:0042430)3.24397283
118cytolysis (GO:0019835)3.19279898
119sodium-independent organic anion transport (GO:0043252)3.18724757
120positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.16802414
121detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.14154638
122killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.08414028
123disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.08414028
124positive regulation of icosanoid secretion (GO:0032305)3.06904881
125vitamin biosynthetic process (GO:0009110)2.96107502
126regulation of humoral immune response (GO:0002920)2.95522967
127regulation of plasminogen activation (GO:0010755)2.90706745
128xenobiotic catabolic process (GO:0042178)2.90548265
129negative regulation of protein activation cascade (GO:2000258)2.86720549
130L-fucose catabolic process (GO:0042355)2.79374364
131fucose catabolic process (GO:0019317)2.79374364
132L-fucose metabolic process (GO:0042354)2.79374364
133regulation of glucokinase activity (GO:0033131)2.78959581
134regulation of hexokinase activity (GO:1903299)2.78959581
135pyrimidine nucleobase catabolic process (GO:0006208)2.77390326

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.30675614
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.13833887
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse7.08315516
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.44056998
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.31851706
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.25124080
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.09201978
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.08940111
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.02441975
10ZNF274_21170338_ChIP-Seq_K562_Hela3.69043577
11VDR_22108803_ChIP-Seq_LS180_Human2.75799392
12GBX2_23144817_ChIP-Seq_PC3_Human2.57961809
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.39346394
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21236956
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14210038
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.04963782
17EZH2_22144423_ChIP-Seq_EOC_Human2.03470992
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02208629
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9459515
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.97825807
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90919243
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.87209344
23IGF1R_20145208_ChIP-Seq_DFB_Human1.86305991
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83887448
25ER_23166858_ChIP-Seq_MCF-7_Human1.83418824
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66499655
27P300_19829295_ChIP-Seq_ESCs_Human1.65934280
28FOXA2_19822575_ChIP-Seq_HepG2_Human1.58062097
29CLOCK_20551151_ChIP-Seq_293T_Human1.56914237
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54417415
31HTT_18923047_ChIP-ChIP_STHdh_Human1.51735193
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49265857
33FOXA1_25329375_ChIP-Seq_VCAP_Human1.46878841
34FOXA1_27270436_Chip-Seq_PROSTATE_Human1.46878841
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46440942
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.45881642
37FUS_26573619_Chip-Seq_HEK293_Human1.45301470
38NANOG_19829295_ChIP-Seq_ESCs_Human1.43878040
39SOX2_19829295_ChIP-Seq_ESCs_Human1.43878040
40CBP_20019798_ChIP-Seq_JUKART_Human1.43552158
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43552158
42EWS_26573619_Chip-Seq_HEK293_Human1.41757716
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41376660
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40513541
45GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.39238329
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39213723
47HNF4A_19822575_ChIP-Seq_HepG2_Human1.38552796
48IRF1_19129219_ChIP-ChIP_H3396_Human1.38451085
49GATA1_22025678_ChIP-Seq_K562_Human1.38252096
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36889508
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36889508
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36868436
53ETV2_25802403_ChIP-Seq_MESCs_Mouse1.36128439
54TP53_22573176_ChIP-Seq_HFKS_Human1.34308249
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.33704182
56AR_25329375_ChIP-Seq_VCAP_Human1.31565849
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30290772
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30185046
59FOXA1_21572438_ChIP-Seq_LNCaP_Human1.28912865
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27570187
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27279167
62NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26737945
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.26091486
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.25764538
65STAT3_23295773_ChIP-Seq_U87_Human1.25242815
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.24491933
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.24367814
68TCF4_22108803_ChIP-Seq_LS180_Human1.23776838
69MYC_19829295_ChIP-Seq_ESCs_Human1.21448962
70TCF4_23295773_ChIP-Seq_U87_Human1.21365221
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19702341
72RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18259168
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17914819
74REST_21632747_ChIP-Seq_MESCs_Mouse1.16503491
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13382271
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11274618
77SMAD4_21799915_ChIP-Seq_A2780_Human1.10824916
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09798526
79RUNX2_22187159_ChIP-Seq_PCA_Human1.08353777
80SMAD4_21741376_ChIP-Seq_EPCs_Human1.08222337
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07835206
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07550527
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07413282
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07360468
85ERA_21632823_ChIP-Seq_H3396_Human1.04202737
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.04161043
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.03701402
88ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03276871
89NANOG_20526341_ChIP-Seq_ESCs_Human1.03275398
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03139332
91MYC_18940864_ChIP-ChIP_HL60_Human1.02631013
92IRF8_22096565_ChIP-ChIP_GC-B_Human1.02294258
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01944851
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01815893
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99725643
96OCT4_20526341_ChIP-Seq_ESCs_Human0.98708098
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98166832
98CBX2_27304074_Chip-Seq_ESCs_Mouse0.96898334
99PHF8_20622853_ChIP-Seq_HELA_Human0.96296392
100HOXB7_26014856_ChIP-Seq_BT474_Human0.95938698
101RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95092222
102RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93521296
103SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88483868
104AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83163170
105PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82362269
106* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78084979
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76494814
108ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76004765
109GATA4_25053715_ChIP-Seq_YYC3_Human0.75839331
110NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.75439395
111RARA_24833708_ChIP-Seq_LIVER_Mouse0.75311741
112ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.74965282
113SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74068068
114E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.73359536
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70765706
116Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70382682
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69359491
118SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68234992
119ZNF263_19887448_ChIP-Seq_K562_Human0.66837896
120ESR2_21235772_ChIP-Seq_MCF-7_Human0.64738216
121* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63955331
122NRF2_20460467_ChIP-Seq_MEFs_Mouse0.63946310
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.63946310
124NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.63288953
125RARB_24833708_ChIP-Seq_LIVER_Mouse0.62572456
126AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.62259387
127RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61472409
128PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.59027221
129* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.56860378
130CEBPB_22108803_ChIP-Seq_LS180_Human0.56447511
131* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.55152249
132LXR_22292898_ChIP-Seq_THP-1_Human0.54682035
133EGR1_19032775_ChIP-ChIP_M12_Human0.51918464
134STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51324864
135MYC_19915707_ChIP-ChIP_AK7_Human0.49204512
136FOXA1_25552417_ChIP-Seq_VCAP_Human0.48470537
137* AR_20517297_ChIP-Seq_VCAP_Human0.48084972
138ESET_19884257_ChIP-Seq_ESCs_Mouse0.47095986
139FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.46519666
140CDX2_20551321_ChIP-Seq_CACO-2_Human0.46334744
141P53_21459846_ChIP-Seq_SAOS-2_Human0.45823374
142CBP_21632823_ChIP-Seq_H3396_Human0.45673479
143FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.45154396
144PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44659363
145PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43502117
146STAT1_17558387_ChIP-Seq_HELA_Human0.43068291
147BCAT_22108803_ChIP-Seq_LS180_Human0.42123322
148ESR1_21235772_ChIP-Seq_MCF-7_Human0.41691589
149GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.41407492
150TAF15_26573619_Chip-Seq_HEK293_Human0.41390343
151* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40996248
152STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.40240940
153TRIM28_21343339_ChIP-Seq_HEK293_Human0.39364924
154PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.39349720
155FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.39155475
156FOXO3_23340844_ChIP-Seq_DLD1_Human0.38304216
157TAF2_19829295_ChIP-Seq_ESCs_Human0.38013065
158GATA1_19941827_ChIP-Seq_MEL_Mouse0.37897687
159GATA2_19941826_ChIP-Seq_K562_Human0.37073373
160GATA1_19941826_ChIP-Seq_K562_Human0.36858864
161NCOR_22424771_ChIP-Seq_293T_Human0.36654926
162SPI1_26923725_Chip-Seq_HPCs_Mouse0.36537036
163MYC_27129775_Chip-Seq_CORNEA_Mouse0.36405194
164GATA6_25053715_ChIP-Seq_YYC3_Human0.36137634
165CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.35384522
166ERG_21242973_ChIP-ChIP_JURKAT_Human0.34827496
167PPAR_26484153_Chip-Seq_NCI-H1993_Human0.34169645
168* FOXH1_21741376_ChIP-Seq_EPCs_Human0.33885622
169LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.33884512
170SOX2_20726797_ChIP-Seq_SW620_Human0.33703218
171CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.33314912
172CDX2_22108803_ChIP-Seq_LS180_Human0.33254027
173CSB_26484114_Chip-Seq_FIBROBLAST_Human0.32537295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.55325033
2MP0005360_urolithiasis7.47437852
3MP0005085_abnormal_gallbladder_physiolo6.43681329
4MP0005365_abnormal_bile_salt6.33584863
5MP0008875_abnormal_xenobiotic_pharmacok5.15531003
6MP0003806_abnormal_nucleotide_metabolis4.09901171
7MP0003252_abnormal_bile_duct3.81798876
8MP0010329_abnormal_lipoprotein_level3.57773596
9MP0009840_abnormal_foam_cell3.47777878
10MP0005083_abnormal_biliary_tract2.94038846
11MP0003195_calcinosis2.93701816
12MP0005332_abnormal_amino_acid2.77531354
13MP0001666_abnormal_nutrient_absorption2.55326925
14MP0005377_hearing/vestibular/ear_phenot2.53526431
15MP0003878_abnormal_ear_physiology2.53526431
16MP0003191_abnormal_cellular_cholesterol2.32547645
17MP0001986_abnormal_taste_sensitivity2.16446486
18MP0000609_abnormal_liver_physiology2.14330212
19MP0002118_abnormal_lipid_homeostasis2.09867904
20MP0004019_abnormal_vitamin_homeostasis2.05537288
21MP0002138_abnormal_hepatobiliary_system2.02599033
22MP0003136_yellow_coat_color1.92607757
23MP0005551_abnormal_eye_electrophysiolog1.89296301
24MP0005319_abnormal_enzyme/_coenzyme1.80717704
25MP0003868_abnormal_feces_composition1.78341918
26MP0001764_abnormal_homeostasis1.71129347
27MP0009697_abnormal_copulation1.69045016
28MP0001485_abnormal_pinna_reflex1.66415856
29MP0002102_abnormal_ear_morphology1.56323637
30MP0000569_abnormal_digit_pigmentation1.56132231
31MP0003646_muscle_fatigue1.53622468
32MP0005584_abnormal_enzyme/coenzyme_acti1.51747030
33MP0004142_abnormal_muscle_tone1.42070328
34MP0005451_abnormal_body_composition1.37709418
35MP0003011_delayed_dark_adaptation1.33777541
36MP0008877_abnormal_DNA_methylation1.32786646
37MP0001501_abnormal_sleep_pattern1.32487770
38MP0006292_abnormal_olfactory_placode1.32274912
39MP0005253_abnormal_eye_physiology1.31347711
40MP0009643_abnormal_urine_homeostasis1.26151338
41MP0009745_abnormal_behavioral_response1.25461141
42MP0001968_abnormal_touch/_nociception1.24809049
43MP0006072_abnormal_retinal_apoptosis1.23942835
44MP0003186_abnormal_redox_activity1.23098330
45MP0004043_abnormal_pH_regulation1.22548567
46MP0002736_abnormal_nociception_after1.20543435
47MP0002638_abnormal_pupillary_reflex1.18113346
48MP0003656_abnormal_erythrocyte_physiolo1.17990548
49MP0003283_abnormal_digestive_organ1.16378804
50MP0000598_abnormal_liver_morphology1.14128097
51MP0000604_amyloidosis1.14113216
52MP0009046_muscle_twitch1.13697110
53MP0005647_abnormal_sex_gland1.12857867
54MP0009764_decreased_sensitivity_to1.10787897
55MP0003705_abnormal_hypodermis_morpholog1.07310984
56MP0001486_abnormal_startle_reflex1.04660508
57MP0009763_increased_sensitivity_to1.03280897
58MP0009785_altered_susceptibility_to1.02860414
59MP0002653_abnormal_ependyma_morphology1.02288720
60MP0002938_white_spotting1.00829257
61MP0004742_abnormal_vestibular_system0.99680776
62MP0005174_abnormal_tail_pigmentation0.99114382
63MP0002234_abnormal_pharynx_morphology0.97016304
64MP0002254_reproductive_system_inflammat0.95801139
65MP0008469_abnormal_protein_level0.93549205
66MP0005646_abnormal_pituitary_gland0.93368290
67MP0004885_abnormal_endolymph0.93161574
68MP0002277_abnormal_respiratory_mucosa0.92895475
69MP0010368_abnormal_lymphatic_system0.92655535
70MP0005645_abnormal_hypothalamus_physiol0.91029150
71MP0002272_abnormal_nervous_system0.90210340
72MP0000372_irregular_coat_pigmentation0.89585255
73* MP0005636_abnormal_mineral_homeostasis0.88558120
74* MP0009642_abnormal_blood_homeostasis0.87837675
75MP0005671_abnormal_response_to0.87714552
76MP0001324_abnormal_eye_pigmentation0.87582644
77MP0002064_seizures0.86237968
78MP0005670_abnormal_white_adipose0.83406158
79MP0001919_abnormal_reproductive_system0.83065082
80MP0005084_abnormal_gallbladder_morpholo0.81900327
81MP0002282_abnormal_trachea_morphology0.81472247
82MP0005386_behavior/neurological_phenoty0.80989925
83MP0004924_abnormal_behavior0.80989925
84MP0005376_homeostasis/metabolism_phenot0.80423712
85MP0005408_hypopigmentation0.79410651
86MP0005171_absent_coat_pigmentation0.78504773
87MP0006036_abnormal_mitochondrial_physio0.78462532
88MP0004147_increased_porphyrin_level0.77656366
89MP0009765_abnormal_xenobiotic_induced0.77156550
90MP0002876_abnormal_thyroid_physiology0.75474084
91MP0002078_abnormal_glucose_homeostasis0.75428427
92MP0003690_abnormal_glial_cell0.75281593
93MP0005195_abnormal_posterior_eye0.72658289
94MP0003137_abnormal_impulse_conducting0.72282019
95MP0002971_abnormal_brown_adipose0.71788654
96MP0009053_abnormal_anal_canal0.71340745
97MP0003329_amyloid_beta_deposits0.71284040
98MP0004215_abnormal_myocardial_fiber0.70864950
99MP0005410_abnormal_fertilization0.69808440
100MP0004133_heterotaxia0.68910549
101MP0002735_abnormal_chemical_nociception0.68664978
102MP0005334_abnormal_fat_pad0.68434061
103MP0000026_abnormal_inner_ear0.68149432
104MP0001963_abnormal_hearing_physiology0.67924806
105MP0005220_abnormal_exocrine_pancreas0.67037667
106MP0002229_neurodegeneration0.66886817
107MP0010386_abnormal_urinary_bladder0.66859315
108MP0001529_abnormal_vocalization0.65069813
109MP0005389_reproductive_system_phenotype0.64897677
110MP0005535_abnormal_body_temperature0.64617765
111MP0002148_abnormal_hypersensitivity_rea0.64460375
112MP0004130_abnormal_muscle_cell0.64406761
113MP0002557_abnormal_social/conspecific_i0.63903953
114MP0002572_abnormal_emotion/affect_behav0.62427107
115MP0005266_abnormal_metabolism0.62005034
116MP0000639_abnormal_adrenal_gland0.59815190
117MP0005464_abnormal_platelet_physiology0.59192974
118MP0001756_abnormal_urination0.57361147
119MP0001661_extended_life_span0.56958884
120MP0005448_abnormal_energy_balance0.52769868
121MP0008874_decreased_physiological_sensi0.50468946
122MP0002822_catalepsy0.48197075
123MP0003638_abnormal_response/metabolism_0.47305231
124MP0002136_abnormal_kidney_physiology0.46888982
125MP0005395_other_phenotype0.46647690
126MP0006035_abnormal_mitochondrial_morpho0.46593870
127MP0003724_increased_susceptibility_to0.46570644
128MP0008873_increased_physiological_sensi0.46360642
129MP0003075_altered_response_to0.43376296
130MP0003436_decreased_susceptibility_to0.42288370
131MP0002928_abnormal_bile_duct0.42018445
132MP0003718_maternal_effect0.40772002
133MP0004782_abnormal_surfactant_physiolog0.40565258
134MP0003953_abnormal_hormone_level0.39996236
135MP0005166_decreased_susceptibility_to0.39063809
136MP0008872_abnormal_physiological_respon0.38171246
137MP0002837_dystrophic_cardiac_calcinosis0.38101050
138MP0000579_abnormal_nail_morphology0.37793312
139MP0005248_abnormal_Harderian_gland0.35284058
140MP0001881_abnormal_mammary_gland0.35110402
141MP0005666_abnormal_adipose_tissue0.34575044
142MP0000249_abnormal_blood_vessel0.33786458
143MP0009115_abnormal_fat_cell0.33427704
144MP0006082_CNS_inflammation0.32080433
145MP0002168_other_aberrant_phenotype0.31939393
146MP0004883_abnormal_blood_vessel0.31667173
147MP0009672_abnormal_birth_weight0.31304044
148MP0001243_abnormal_dermal_layer0.30706481
149MP0002970_abnormal_white_adipose0.29688116
150MP0001853_heart_inflammation0.29369869
151MP0000230_abnormal_systemic_arterial0.29115326
152MP0001845_abnormal_inflammatory_respons0.28785793
153MP0002796_impaired_skin_barrier0.27415260
154MP0005164_abnormal_response_to0.27155628
155MP0009384_cardiac_valve_regurgitation0.27018653
156MP0004381_abnormal_hair_follicle0.26544261
157MP0005167_abnormal_blood-brain_barrier0.26364949
158MP0002132_abnormal_respiratory_system0.24273456
159MP0002135_abnormal_kidney_morphology0.23316053

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.51857750
2Deep venous thrombosis (HP:0002625)7.39669767
3Intrahepatic cholestasis (HP:0001406)7.14031503
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.95321097
5Prolonged partial thromboplastin time (HP:0003645)6.64176988
6Hypobetalipoproteinemia (HP:0003563)6.60626266
7Xanthomatosis (HP:0000991)6.27433637
8Hyperlipoproteinemia (HP:0010980)5.75503696
9Complement deficiency (HP:0004431)5.25436182
10Joint hemorrhage (HP:0005261)4.88100964
11Hypolipoproteinemia (HP:0010981)4.87259122
12Hyperammonemia (HP:0001987)4.59149941
13Abnormality of the common coagulation pathway (HP:0010990)4.56456790
14Epidermoid cyst (HP:0200040)4.49371671
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.43908031
16Abnormality of methionine metabolism (HP:0010901)4.35220163
17Ketosis (HP:0001946)4.27550622
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.26972070
19Hypoalphalipoproteinemia (HP:0003233)4.26033706
20Hyperglycinemia (HP:0002154)4.23507821
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.17508227
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.13374891
23Fat malabsorption (HP:0002630)4.08327967
24Abnormality of pyrimidine metabolism (HP:0004353)4.05821133
25Hypoglycemic coma (HP:0001325)4.01671184
26Abnormality of complement system (HP:0005339)3.82971382
27Hyperglycinuria (HP:0003108)3.82192465
28Abnormality of glycine metabolism (HP:0010895)3.76460190
29Abnormality of serine family amino acid metabolism (HP:0010894)3.76460190
30Abnormality of the intrinsic pathway (HP:0010989)3.73809745
31Hypercholesterolemia (HP:0003124)3.68707389
32Conjugated hyperbilirubinemia (HP:0002908)3.60479320
33Congenital stationary night blindness (HP:0007642)3.45645886
34Spontaneous abortion (HP:0005268)3.35185035
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.33579135
36Hyperbilirubinemia (HP:0002904)3.32636423
37Abnormality of fatty-acid metabolism (HP:0004359)3.27444041
38Pancreatic cysts (HP:0001737)3.19542641
39Steatorrhea (HP:0002570)3.14671612
40Abnormality of nucleobase metabolism (HP:0010932)3.14613058
41Ketoacidosis (HP:0001993)3.08612404
42True hermaphroditism (HP:0010459)3.08198004
43Myocardial infarction (HP:0001658)3.00897222
44Delayed CNS myelination (HP:0002188)2.99870388
45Fair hair (HP:0002286)2.98945110
46Abnormality of serum amino acid levels (HP:0003112)2.98921530
47Abnormality of midbrain morphology (HP:0002418)2.92586883
48Molar tooth sign on MRI (HP:0002419)2.92586883
49Pancreatic fibrosis (HP:0100732)2.89976251
50Hepatocellular carcinoma (HP:0001402)2.83034028
51Hypochromic microcytic anemia (HP:0004840)2.81594751
52Hyperventilation (HP:0002883)2.77677013
53Skin nodule (HP:0200036)2.76487675
54Abnormality of the renal cortex (HP:0011035)2.72780077
55Systemic lupus erythematosus (HP:0002725)2.70371599
56Metabolic acidosis (HP:0001942)2.69946992
57Hypoglycemic seizures (HP:0002173)2.69774601
58Vascular calcification (HP:0004934)2.69078351
59Abnormality of purine metabolism (HP:0004352)2.69009020
60Mitral stenosis (HP:0001718)2.63196476
61Lethargy (HP:0001254)2.63071202
62Amyloidosis (HP:0011034)2.55578635
63Cerebral edema (HP:0002181)2.53057774
64Abolished electroretinogram (ERG) (HP:0000550)2.49537096
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.48983188
66Dicarboxylic aciduria (HP:0003215)2.48983188
67Spastic diplegia (HP:0001264)2.48031526
68Glomerulonephritis (HP:0000099)2.46430561
69Nephronophthisis (HP:0000090)2.45797653
70Gingival bleeding (HP:0000225)2.45206960
71Abnormal gallbladder morphology (HP:0012437)2.42313654
72Chronic hepatic failure (HP:0100626)2.41390470
73Irritability (HP:0000737)2.39744450
74Attenuation of retinal blood vessels (HP:0007843)2.39549741
75Late onset (HP:0003584)2.39308173
76Cardiovascular calcification (HP:0011915)2.38940200
77Neonatal onset (HP:0003623)2.37538624
78Bile duct proliferation (HP:0001408)2.37537158
79Abnormal biliary tract physiology (HP:0012439)2.37537158
80Cholelithiasis (HP:0001081)2.36860268
81Type II lissencephaly (HP:0007260)2.35175603
82Recurrent gram-negative bacterial infections (HP:0005420)2.34766932
83Acanthocytosis (HP:0001927)2.34573807
84Decreased central vision (HP:0007663)2.33190522
85Gout (HP:0001997)2.26912281
86Abnormality of alanine metabolism (HP:0010916)2.26324927
87Hyperalaninemia (HP:0003348)2.26324927
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26324927
89Hypothermia (HP:0002045)2.25644598
90Hyperinsulinemic hypoglycemia (HP:0000825)2.23351919
91Generalized hypopigmentation of hair (HP:0011358)2.22667687
92Abnormality of the renal medulla (HP:0100957)2.19470207
93Cholecystitis (HP:0001082)2.19397117
94Abnormal gallbladder physiology (HP:0012438)2.19397117
95Menorrhagia (HP:0000132)2.18889814
96Abnormal drinking behavior (HP:0030082)2.18735103
97Polydipsia (HP:0001959)2.18735103
98Thrombophlebitis (HP:0004418)2.17423563
99Brushfield spots (HP:0001088)2.17407331
100Medial flaring of the eyebrow (HP:0010747)2.14769936
101Malnutrition (HP:0004395)2.12605904
102Esophageal varix (HP:0002040)2.11775886
103Congenital, generalized hypertrichosis (HP:0004540)2.11593421
104Pancreatitis (HP:0001733)2.09066949
1053-Methylglutaconic aciduria (HP:0003535)2.08658968
106Sensorimotor neuropathy (HP:0007141)2.07897381
107Vomiting (HP:0002013)2.07094001
108Opisthotonus (HP:0002179)2.04903774
109Abnormality of urine glucose concentration (HP:0011016)2.04149611
110Glycosuria (HP:0003076)2.04149611
111Pendular nystagmus (HP:0012043)2.03677832
112Enlarged kidneys (HP:0000105)2.01954137
113Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01272761
114Inability to walk (HP:0002540)1.99112955
115Poikilocytosis (HP:0004447)1.98748865
116Hemorrhage of the eye (HP:0011885)1.97675531
117Cystic liver disease (HP:0006706)1.97271717
118Mitochondrial inheritance (HP:0001427)1.95463663
119Acute encephalopathy (HP:0006846)1.95400902
120Abnormality of the gallbladder (HP:0005264)1.94961756
121Generalized aminoaciduria (HP:0002909)1.94437549
122Rickets (HP:0002748)1.92775970
123Increased CSF lactate (HP:0002490)1.91945348
124Hypophosphatemic rickets (HP:0004912)1.91100530
125Hyperglycemia (HP:0003074)1.90796791
126Tubular atrophy (HP:0000092)1.87875072
127Dynein arm defect of respiratory motile cilia (HP:0012255)1.87457895
128Absent/shortened dynein arms (HP:0200106)1.87457895
129Abnormality of proline metabolism (HP:0010907)1.87101157
130Hydroxyprolinuria (HP:0003080)1.87101157
131Abnormal rod and cone electroretinograms (HP:0008323)1.86740599
132Decreased circulating renin level (HP:0003351)1.85035514
133Acute necrotizing encephalopathy (HP:0006965)1.84865213
134Abnormal cartilage morphology (HP:0002763)1.83257102
135Nephritis (HP:0000123)1.82995738
136Alkalosis (HP:0001948)1.82919919
137Polyuria (HP:0000103)1.82060430
138Methylmalonic acidemia (HP:0002912)1.81610413
139Keratoconus (HP:0000563)1.79212648
140Increased corneal curvature (HP:0100692)1.79212648
141Elevated hepatic transaminases (HP:0002910)1.76846816
142Mesangial abnormality (HP:0001966)1.76149007
143Abnormal urine output (HP:0012590)1.75933514
144Renal cortical cysts (HP:0000803)1.75377186
145Lipid accumulation in hepatocytes (HP:0006561)1.75372243
146Symptomatic seizures (HP:0011145)1.75361398
147Reticulocytosis (HP:0001923)1.75046893
148Hepatic necrosis (HP:0002605)1.74196279
149Status epilepticus (HP:0002133)1.74030221
150Abnormal enzyme/coenzyme activity (HP:0012379)1.73596547
151Optic disc pallor (HP:0000543)1.70823620
152Abnormality of vitamin metabolism (HP:0100508)1.69966991
153Male pseudohermaphroditism (HP:0000037)1.69050133
154Congenital sensorineural hearing impairment (HP:0008527)1.66932439
155Methylmalonic aciduria (HP:0012120)1.66265149
156Thyroiditis (HP:0100646)1.65866579
157Progressive inability to walk (HP:0002505)1.63818398
158Progressive cerebellar ataxia (HP:0002073)1.63528708
159Arthropathy (HP:0003040)1.63454932
160Focal motor seizures (HP:0011153)1.63292983
161CNS demyelination (HP:0007305)1.62088847
162Hepatocellular necrosis (HP:0001404)1.61936621

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.07521795
2FGFR44.67441920
3SIK14.67333343
4ERN14.51364000
5ADRBK23.72025311
6TAOK33.35118091
7ERBB42.90017514
8MAP4K22.87780962
9INSRR2.80322075
10ZAK2.79292137
11WNK32.67270159
12BMPR1B2.61905913
13TXK2.58127344
14WNK42.55281874
15ACVR1B2.46983297
16DAPK22.40943498
17MAP2K42.22513567
18PIK3CG2.03587627
19MST1R1.96803479
20PKN21.96128750
21MAPK131.87075053
22MAPK111.81052468
23FLT31.74577822
24TRIB31.68858572
25TLK11.67849969
26TYK21.64706226
27PNCK1.60222674
28GRK71.59659401
29CAMKK21.57618758
30NUAK11.55665178
31PTK61.51791913
32OXSR11.49290840
33ABL21.47561207
34LATS11.39867119
35STK391.35482757
36FRK1.33343707
37JAK21.25840772
38KDR1.25557023
39ADRBK11.25127848
40NEK91.23752021
41FGFR21.21982142
42TBK11.19063243
43MAP3K41.15380764
44MAP3K141.10852512
45TGFBR11.09339592
46MAP3K71.09235844
47GRK61.09216665
48MAPK151.06844610
49IKBKB1.05554561
50CASK1.04330737
51PRKAA21.03716510
52CCNB11.03326833
53EPHB11.02969882
54ERBB21.00893370
55VRK11.00754993
56PINK11.00090628
57JAK10.99135671
58DYRK20.96389398
59MAP2K30.94788756
60MAPK40.93922565
61MUSK0.91556343
62EPHA30.90510197
63PRKCZ0.90364274
64BRSK20.90148915
65MAPKAPK30.89526405
66MAP3K110.89115758
67MAPK120.87311653
68PDK20.84262971
69CAMK2G0.84136216
70PRKCE0.82743138
71TSSK60.80475281
72PRKACG0.80113078
73TNIK0.78796178
74MET0.78578149
75MAP3K100.78475854
76MAP2K60.77630656
77MAP3K30.76598989
78NTRK30.76156868
79WEE10.75877162
80DYRK1B0.75857564
81CSK0.74553400
82NTRK20.73487049
83TIE10.73199224
84TEC0.71775050
85EPHA40.71385504
86CDK60.71100107
87TNK20.68820971
88PIK3CA0.67741634
89MAPKAPK50.67514340
90SYK0.67034561
91RIPK10.66489351
92CAMK1D0.66428270
93CHUK0.66397695
94IKBKE0.63497542
95STK38L0.62116028
96PHKG20.60699065
97PHKG10.60699065
98MKNK20.60592050
99GSK3A0.60315151
100PRKAA10.55799745
101PDPK10.55107106
102MAP2K10.54848124
103MAP4K10.54786998
104PTK20.54760873
105CSF1R0.54271631
106SGK30.54100985
107NLK0.53899681
108MAPK70.53758288
109IRAK10.53332240
110CSNK1G10.51408318
111LYN0.49991181
112TGFBR20.49861819
113TAOK20.49516640
114PRKG10.49388048
115PRKCQ0.48970539
116IRAK30.48931617
117FGFR30.47856548
118MAP3K130.47086323
119IGF1R0.46917941
120MARK10.46697817
121ITK0.46447455
122BLK0.46418120
123RPS6KA50.44788345
124PRKCG0.44651348
125PKN10.44154507
126TRIM280.40162198
127ICK0.40103914
128CAMK2A0.39799157
129STK110.39608587
130CAMK40.39292667
131CSNK1A10.39093150
132CSNK1G30.37613245
133GRK10.37248023
134CSNK1G20.36995554
135SGK20.36584771
136VRK20.36329666
137MAP2K70.36033614
138EGFR0.35943468
139RET0.35433791
140CDK40.35216334
141MTOR0.35069503
142MAP3K50.34827362
143FER0.34765062
144PDK10.34229675
145LCK0.34219237
146ABL10.33881935
147GRK50.32376280
148CSNK1D0.30451068
149JAK30.30420450
150PRKCA0.29272326
151MAP2K20.29164882
152CSNK1A1L0.28105669
153MAP3K10.27563779
154MKNK10.26935359
155PRKACB0.25384503
156PAK30.25052849
157PBK0.24777808
158SGK2230.24400337
159SGK4940.24400337
160LATS20.22844885
161KIT0.22462107
162MAPK30.20993437
163BMX0.19776797
164MAP3K60.19744896
165PRKACA0.18682810

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.55146426
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.44525948
3Nitrogen metabolism_Homo sapiens_hsa009103.36021093
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.35616985
5Arginine biosynthesis_Homo sapiens_hsa002203.12337127
6Complement and coagulation cascades_Homo sapiens_hsa046102.80239595
7Tryptophan metabolism_Homo sapiens_hsa003802.72027115
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.64109281
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.56232411
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.54081181
11Fatty acid degradation_Homo sapiens_hsa000712.39991393
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.34619180
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32991853
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25731255
15Chemical carcinogenesis_Homo sapiens_hsa052042.13598895
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.10426025
17Peroxisome_Homo sapiens_hsa041462.10213323
18Butanoate metabolism_Homo sapiens_hsa006502.07773143
19Histidine metabolism_Homo sapiens_hsa003401.93562858
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.90495518
21Caffeine metabolism_Homo sapiens_hsa002321.90138952
22PPAR signaling pathway_Homo sapiens_hsa033201.87951847
23Propanoate metabolism_Homo sapiens_hsa006401.85924998
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.80200385
25Staphylococcus aureus infection_Homo sapiens_hsa051501.79567558
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74594156
27Fatty acid metabolism_Homo sapiens_hsa012121.71540864
28Retinol metabolism_Homo sapiens_hsa008301.69490677
29beta-Alanine metabolism_Homo sapiens_hsa004101.66491011
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64919970
31Phenylalanine metabolism_Homo sapiens_hsa003601.61408473
32Selenocompound metabolism_Homo sapiens_hsa004501.56536252
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51386009
34Bile secretion_Homo sapiens_hsa049761.48029148
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48022609
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47912662
37Tyrosine metabolism_Homo sapiens_hsa003501.45841366
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.34651275
39Sulfur metabolism_Homo sapiens_hsa009201.31971349
40Pyruvate metabolism_Homo sapiens_hsa006201.31717077
41Folate biosynthesis_Homo sapiens_hsa007901.29916166
42Starch and sucrose metabolism_Homo sapiens_hsa005001.28984336
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27645239
44Fatty acid elongation_Homo sapiens_hsa000621.24672629
45Biosynthesis of amino acids_Homo sapiens_hsa012301.19815446
46Fat digestion and absorption_Homo sapiens_hsa049751.19653779
47ABC transporters_Homo sapiens_hsa020101.19541863
48Steroid biosynthesis_Homo sapiens_hsa001001.17301282
49Carbon metabolism_Homo sapiens_hsa012001.09285248
50Phototransduction_Homo sapiens_hsa047441.08609805
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.07670417
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05141833
53Arginine and proline metabolism_Homo sapiens_hsa003300.99642939
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.98655627
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97940704
56Oxidative phosphorylation_Homo sapiens_hsa001900.95768441
57Sulfur relay system_Homo sapiens_hsa041220.95541829
58Vitamin B6 metabolism_Homo sapiens_hsa007500.91045290
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90821632
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82880315
61Vitamin digestion and absorption_Homo sapiens_hsa049770.81991980
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81115031
63Glutathione metabolism_Homo sapiens_hsa004800.79374530
64Ether lipid metabolism_Homo sapiens_hsa005650.78764347
65Lysine degradation_Homo sapiens_hsa003100.77382993
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.76598154
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74665575
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74030639
69One carbon pool by folate_Homo sapiens_hsa006700.70063482
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69768649
71Glycerolipid metabolism_Homo sapiens_hsa005610.63600206
72Asthma_Homo sapiens_hsa053100.62897143
73Protein export_Homo sapiens_hsa030600.62123486
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57622327
75Parkinsons disease_Homo sapiens_hsa050120.55880689
76Pentose phosphate pathway_Homo sapiens_hsa000300.54307957
77Nicotine addiction_Homo sapiens_hsa050330.53904344
78Fatty acid biosynthesis_Homo sapiens_hsa000610.46840330
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46232914
80Metabolic pathways_Homo sapiens_hsa011000.44804295
81Serotonergic synapse_Homo sapiens_hsa047260.40414291
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40054404
83Homologous recombination_Homo sapiens_hsa034400.39331691
84Mineral absorption_Homo sapiens_hsa049780.39309962
85RNA polymerase_Homo sapiens_hsa030200.37909265
86Taste transduction_Homo sapiens_hsa047420.37350970
87Fanconi anemia pathway_Homo sapiens_hsa034600.36507803
88Prion diseases_Homo sapiens_hsa050200.34716889
89Graft-versus-host disease_Homo sapiens_hsa053320.33368239
90Primary immunodeficiency_Homo sapiens_hsa053400.32268945
91Rheumatoid arthritis_Homo sapiens_hsa053230.30508797
92Allograft rejection_Homo sapiens_hsa053300.30204715
93Type I diabetes mellitus_Homo sapiens_hsa049400.30173840
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30162636
95Basal transcription factors_Homo sapiens_hsa030220.29935072
96Autoimmune thyroid disease_Homo sapiens_hsa053200.27609119
97Galactose metabolism_Homo sapiens_hsa000520.27386955
98Fructose and mannose metabolism_Homo sapiens_hsa000510.24020004
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.23968461
100Alzheimers disease_Homo sapiens_hsa050100.23214568
101Huntingtons disease_Homo sapiens_hsa050160.21909077
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20866031
103Insulin resistance_Homo sapiens_hsa049310.20697452
104Linoleic acid metabolism_Homo sapiens_hsa005910.20297107
105GABAergic synapse_Homo sapiens_hsa047270.19954339
106Collecting duct acid secretion_Homo sapiens_hsa049660.19034459
107Olfactory transduction_Homo sapiens_hsa047400.18850680
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.18832433
109Morphine addiction_Homo sapiens_hsa050320.16201598
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.13388918
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12771349
112Glucagon signaling pathway_Homo sapiens_hsa049220.10297393
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.2538022
114Type II diabetes mellitus_Homo sapiens_hsa04930-0.2507052
115Pertussis_Homo sapiens_hsa05133-0.2470352
116Amoebiasis_Homo sapiens_hsa05146-0.2297627
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2289477
118Bladder cancer_Homo sapiens_hsa05219-0.2096180
119Renin-angiotensin system_Homo sapiens_hsa04614-0.1972882
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1955178
121Hepatitis C_Homo sapiens_hsa05160-0.1835573
122Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1806183
123Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1746306
124Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1727830
125Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1659719
126Regulation of autophagy_Homo sapiens_hsa04140-0.1599881
127Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1555846
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1555392
129African trypanosomiasis_Homo sapiens_hsa05143-0.1244415
130Insulin signaling pathway_Homo sapiens_hsa04910-0.1080310
131Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0885066
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0489987
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0208591
134AMPK signaling pathway_Homo sapiens_hsa04152-0.0008944

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