HAND1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H2A monoubiquitination (GO:0035518)6.82534033
2negative regulation of cardiac muscle cell apoptotic process (GO:0010667)6.70614703
3regulation of cardioblast differentiation (GO:0051890)6.68902747
4purine nucleobase biosynthetic process (GO:0009113)6.62200681
5cell migration involved in heart development (GO:0060973)6.60835294
6ribosome assembly (GO:0042255)6.04991067
7nucleobase biosynthetic process (GO:0046112)5.92871846
8branching involved in labyrinthine layer morphogenesis (GO:0060670)5.62490082
9outflow tract septum morphogenesis (GO:0003148)5.61688393
10regulation of secondary heart field cardioblast proliferation (GO:0003266)5.39967689
11regulation of cardioblast proliferation (GO:0003264)5.39967689
12histone H2A ubiquitination (GO:0033522)5.39566686
13positive regulation of transcription regulatory region DNA binding (GO:2000679)5.38860007
14mesenchymal cell proliferation (GO:0010463)5.23719091
15negative regulation of striated muscle cell apoptotic process (GO:0010664)5.20400432
16keratinocyte development (GO:0003334)5.16498177
17lung-associated mesenchyme development (GO:0060484)5.16123633
18regulation of G0 to G1 transition (GO:0070316)5.04693884
19regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901214.93581815
20* trophectodermal cell differentiation (GO:0001829)4.89752834
21vitamin transmembrane transport (GO:0035461)4.76508743
22cranial suture morphogenesis (GO:0060363)4.62235162
23regulation of heart morphogenesis (GO:2000826)4.62123599
24mitotic metaphase plate congression (GO:0007080)4.56629371
25enteric nervous system development (GO:0048484)4.55003882
26coronary vasculature morphogenesis (GO:0060977)4.52798521
27* cardiac chamber formation (GO:0003207)4.49053862
28regulation of transforming growth factor beta2 production (GO:0032909)4.46348176
29regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.43131076
30placenta development (GO:0001890)4.31064655
31regulation of spindle organization (GO:0090224)4.30696718
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.26880331
33* cartilage morphogenesis (GO:0060536)4.21366761
34regulation of cell proliferation involved in heart morphogenesis (GO:2000136)4.20482078
35ribosome biogenesis (GO:0042254)4.14381176
36* cardiac ventricle formation (GO:0003211)4.09471207
37regulation of cardiac muscle cell apoptotic process (GO:0010665)4.03040446
38labyrinthine layer development (GO:0060711)4.02453341
39atrial septum morphogenesis (GO:0060413)4.02120961
40folic acid metabolic process (GO:0046655)3.99432427
41craniofacial suture morphogenesis (GO:0097094)3.97577328
42formation of translation preinitiation complex (GO:0001731)3.94992176
43sympathetic nervous system development (GO:0048485)3.92565742
44nuclear pore organization (GO:0006999)3.87490045
45mitotic sister chromatid segregation (GO:0000070)3.81432198
46peripheral nervous system neuron development (GO:0048935)3.78505979
47adult heart development (GO:0007512)3.77851011
48regulation of striated muscle cell apoptotic process (GO:0010662)3.77030055
49mitotic nuclear envelope disassembly (GO:0007077)3.72165599
50mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.69516942
51atrioventricular valve morphogenesis (GO:0003181)3.65495649
52* cardiac muscle tissue morphogenesis (GO:0055008)3.63852424
53histone monoubiquitination (GO:0010390)3.61612500
54positive regulation of SMAD protein import into nucleus (GO:0060391)3.59932315
55endocardial cushion morphogenesis (GO:0003203)3.59767747
56chaperone-mediated protein complex assembly (GO:0051131)3.58160724
57membrane disassembly (GO:0030397)3.56169108
58nuclear envelope disassembly (GO:0051081)3.56169108
59regulation of translational termination (GO:0006449)3.56020450
60positive regulation of cell size (GO:0045793)3.55268429
61IMP biosynthetic process (GO:0006188)3.54866904
62negative regulation of vascular permeability (GO:0043116)3.54235044
63* ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.54071340
64embryonic skeletal joint morphogenesis (GO:0060272)3.52777046
65folic acid-containing compound biosynthetic process (GO:0009396)3.52487359
66regulation of mitotic spindle organization (GO:0060236)3.50485493
67endocardial cushion development (GO:0003197)3.46280720
68nuclear pore complex assembly (GO:0051292)3.46271892
69desmosome organization (GO:0002934)3.44377104
70maturation of SSU-rRNA (GO:0030490)3.43928008
71metaphase plate congression (GO:0051310)3.43323118
72regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.42942014
73protein localization to kinetochore (GO:0034501)3.41138198
74negative regulation of smooth muscle cell differentiation (GO:0051151)3.39819681
75lung morphogenesis (GO:0060425)3.39141062
76hippo signaling (GO:0035329)3.39022232
77* muscle tissue morphogenesis (GO:0060415)3.36335090
78regulation of centrosome cycle (GO:0046605)3.36327437
79cellular response to BMP stimulus (GO:0071773)3.35523411
80response to BMP (GO:0071772)3.35523411
81pre-miRNA processing (GO:0031054)3.32464612
82bundle of His cell to Purkinje myocyte communication (GO:0086069)3.32339767
83* cardiac septum morphogenesis (GO:0060411)3.31400930
84cell migration in hindbrain (GO:0021535)3.29851931
85mitotic spindle checkpoint (GO:0071174)3.29598605
86spindle checkpoint (GO:0031577)3.29108872
87sister chromatid segregation (GO:0000819)3.28701196
88plasma membrane repair (GO:0001778)3.26979247
89folic acid transport (GO:0015884)3.26971787
90DNA replication checkpoint (GO:0000076)3.25408036
91cardiac myofibril assembly (GO:0055003)3.25230258
92positive regulation of chromosome segregation (GO:0051984)3.23591452
93exocrine pancreas development (GO:0031017)3.21967395
94cardiac muscle cell development (GO:0055013)3.19017831
95progesterone metabolic process (GO:0042448)3.16117796
96peptidyl-arginine omega-N-methylation (GO:0035247)3.15719969
97NLS-bearing protein import into nucleus (GO:0006607)3.14014101
98cytoskeletal anchoring at plasma membrane (GO:0007016)3.13464548
99outer ear morphogenesis (GO:0042473)3.12951402
100positive regulation of cardiac muscle tissue development (GO:0055025)3.12329610
101tongue development (GO:0043586)3.11959272
102positive regulation of cardiac muscle cell proliferation (GO:0060045)3.11957423
103mitotic G2 DNA damage checkpoint (GO:0007095)3.09065721
104* cell differentiation involved in embryonic placenta development (GO:0060706)3.08854572
105dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.07982201
106ribonucleoprotein complex biogenesis (GO:0022613)3.06982192
107regulation of lipoprotein metabolic process (GO:0050746)3.06297498
108mitotic spindle assembly checkpoint (GO:0007094)3.05312180
109* blastocyst development (GO:0001824)3.04893430
110embryonic foregut morphogenesis (GO:0048617)3.04184110
111nuclear envelope organization (GO:0006998)3.03247044
112regulation of smooth muscle cell differentiation (GO:0051150)3.02696731
113anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.01500660
114negative regulation of chromosome segregation (GO:0051985)3.01232546
115histone-serine phosphorylation (GO:0035404)3.00389951
116histone H4-K12 acetylation (GO:0043983)3.00325269
117gastrulation with mouth forming second (GO:0001702)2.99202217
118cell surface receptor signaling pathway involved in heart development (GO:0061311)2.98450494
119cell migration involved in gastrulation (GO:0042074)2.98033603
120negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96024079
121negative regulation of sister chromatid segregation (GO:0033046)2.96024079
122negative regulation of mitotic sister chromatid separation (GO:2000816)2.96024079
123negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96024079
124intestinal epithelial cell development (GO:0060576)2.95205366
125muscle cell fate commitment (GO:0042693)2.94856558
126spindle assembly checkpoint (GO:0071173)2.94094386
127establishment of protein localization to mitochondrial membrane (GO:0090151)2.94029052
128C21-steroid hormone biosynthetic process (GO:0006700)2.92765980
129rRNA processing (GO:0006364)2.92546618
130regulation of chromosome segregation (GO:0051983)2.91545169
131mesenchyme morphogenesis (GO:0072132)2.90354039
132mitotic G2/M transition checkpoint (GO:0044818)2.89873132
133cardiac cell development (GO:0055006)2.89312009
134histone ubiquitination (GO:0016574)2.88983943
135sarcomere organization (GO:0045214)2.87540529
136cardiac septum development (GO:0003279)2.87295142
137respiratory tube development (GO:0030323)2.87284597
138regulation of hair follicle development (GO:0051797)2.87040294
139positive regulation of hormone biosynthetic process (GO:0046886)2.86406933
140uterus development (GO:0060065)2.86392629
141ventricular septum morphogenesis (GO:0060412)2.84979781
142negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.84814931
143ventricular cardiac muscle cell action potential (GO:0086005)2.84583754
144rRNA metabolic process (GO:0016072)2.83687796
145spliceosomal snRNP assembly (GO:0000387)2.83654171
146DNA replication initiation (GO:0006270)2.83425383
147regulation of glycogen (starch) synthase activity (GO:2000465)2.82284023
148positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.82133146
149establishment of chromosome localization (GO:0051303)2.82041921
150heart morphogenesis (GO:0003007)2.81143160
151regulation of tight junction assembly (GO:2000810)2.80792595
152IMP metabolic process (GO:0046040)2.80654588
153negative regulation of epidermis development (GO:0045683)2.80257163
154regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.79714804
155regulation of mitotic metaphase/anaphase transition (GO:0030071)2.79367562
156embryonic digestive tract morphogenesis (GO:0048557)2.79197602
157phenol-containing compound catabolic process (GO:0019336)2.77627906
158paraxial mesoderm development (GO:0048339)2.77193969
159labyrinthine layer blood vessel development (GO:0060716)2.77105098
160ventricular cardiac muscle cell development (GO:0055015)2.76286202
161axis elongation (GO:0003401)2.76256483
162positive regulation of vasculogenesis (GO:2001214)2.76180111
163positive regulation of cardiac muscle tissue growth (GO:0055023)2.75327344
164basement membrane organization (GO:0071711)2.75230503
165regulation of cardiac muscle tissue development (GO:0055024)2.73562149
166regulation of organ formation (GO:0003156)2.73285696
167neural crest cell migration (GO:0001755)2.73192150
168peptidyl-arginine N-methylation (GO:0035246)2.73146766
169peptidyl-arginine methylation (GO:0018216)2.73146766
170negative regulation of cartilage development (GO:0061037)2.71792389
171organ formation (GO:0048645)2.71607308
172negative regulation of histone methylation (GO:0031061)2.71595301
173regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.71084505
174galactose catabolic process (GO:0019388)2.69842553
175wound healing, spreading of epidermal cells (GO:0035313)2.69462089
176regulation of cardiac muscle cell proliferation (GO:0060043)2.69291672
177myofibril assembly (GO:0030239)2.68017186
178apoptotic process involved in morphogenesis (GO:0060561)2.66601620
179hindlimb morphogenesis (GO:0035137)2.63028805
180cardiac muscle hypertrophy (GO:0003300)2.62420025
181cardiac right ventricle morphogenesis (GO:0003215)2.61181800
182SMAD protein signal transduction (GO:0060395)2.59731268
183branch elongation of an epithelium (GO:0060602)2.59486548
184behavioral response to ethanol (GO:0048149)2.58890280
185smooth muscle cell differentiation (GO:0051145)2.58707718
186branching involved in prostate gland morphogenesis (GO:0060442)2.58123045
187regulation of transcription regulatory region DNA binding (GO:2000677)2.57787072
188positive regulation of insulin receptor signaling pathway (GO:0046628)2.57142355
189dorsal/ventral axis specification (GO:0009950)2.56150610
190regulation of SMAD protein import into nucleus (GO:0060390)2.55816074
191notochord development (GO:0030903)2.54976967
192mesenchymal to epithelial transition (GO:0060231)2.54584629
193cell communication by electrical coupling (GO:0010644)2.53694555

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.80752270
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.17431095
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.89399883
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.60622752
5AR_21909140_ChIP-Seq_LNCAP_Human3.43822569
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.27746820
7CREB1_15753290_ChIP-ChIP_HEK293T_Human2.95208896
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75044784
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.64201227
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58252782
11NELFA_20434984_ChIP-Seq_ESCs_Mouse2.52557714
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.46841010
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.32297836
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.32251672
15ZNF263_19887448_ChIP-Seq_K562_Human2.31258669
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.29135864
17SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.27116433
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24831771
19* EZH2_27304074_Chip-Seq_ESCs_Mouse2.24334614
20XRN2_22483619_ChIP-Seq_HELA_Human2.23195764
21* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.22739749
22DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.16820063
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.15947205
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.13129504
25EGR1_19374776_ChIP-ChIP_THP-1_Human2.13040168
26* EOMES_20176728_ChIP-ChIP_TSCs_Mouse2.07161212
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.05185219
28* EED_16625203_ChIP-ChIP_MESCs_Mouse2.02699748
29GABP_17652178_ChIP-ChIP_JURKAT_Human2.00545398
30* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.99231764
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.98182623
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.96210193
33CLOCK_20551151_ChIP-Seq_293T_Human1.89615020
34KLF4_18555785_ChIP-Seq_MESCs_Mouse1.89342673
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.88663255
36* ISL1_27105846_Chip-Seq_CPCs_Mouse1.85025952
37GABP_19822575_ChIP-Seq_HepG2_Human1.84547738
38* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.82910353
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80408072
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78860558
41* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78324834
42* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78324834
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77762602
44HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.77708561
45DCP1A_22483619_ChIP-Seq_HELA_Human1.77298657
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77295128
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77201394
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.75852145
49* TP53_20018659_ChIP-ChIP_R1E_Mouse1.74780462
50* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.74214621
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.72980297
52MYC_22102868_ChIP-Seq_BL_Human1.69736117
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.65574205
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60891234
55TTF2_22483619_ChIP-Seq_HELA_Human1.60493805
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.57626435
57* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55793058
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55770775
59KDM5A_27292631_Chip-Seq_BREAST_Human1.54576504
60* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54487701
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.53158318
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.53015200
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52981366
64ESR2_21235772_ChIP-Seq_MCF-7_Human1.50686516
65TRIM28_21343339_ChIP-Seq_HEK293_Human1.49960520
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47831747
67SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.47246815
68VDR_23849224_ChIP-Seq_CD4+_Human1.43921278
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43328393
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41251666
71HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.39259189
72* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38384795
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38141911
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35307310
75ATF3_27146783_Chip-Seq_COLON_Human1.35034161
76* TP63_19390658_ChIP-ChIP_HaCaT_Human1.33295199
77TP63_17297297_ChIP-ChIP_HaCaT_Human1.32095011
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.30538306
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29205230
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27521792
81SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26698645
82* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25460796
83WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24867481
84* RING1B_27294783_Chip-Seq_NPCs_Mouse1.23986236
85* NANOG_16153702_ChIP-ChIP_HESCs_Human1.23898915
86* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.23703908
87KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23493114
88KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23493114
89KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23493114
90* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22789127
91RNF2_27304074_Chip-Seq_NSC_Mouse1.22745971
92OCT4_18692474_ChIP-Seq_MEFs_Mouse1.22077044
93NANOG_21062744_ChIP-ChIP_HESCs_Human1.20992170
94ELK3_25401928_ChIP-Seq_HUVEC_Human1.20385442
95THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20282713
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19859994
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19614392
98* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.18822080
99ELK1_22589737_ChIP-Seq_MCF10A_Human1.16981678
100ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16638707
101* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14411696
102STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.13630158
103EP300_21415370_ChIP-Seq_HL-1_Mouse1.13460066
104ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12609313
105CHD1_26751641_Chip-Seq_LNCaP_Human1.11952077
106YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11074944
107* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10928742
108GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.10172783
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08943738
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08505050
111RACK7_27058665_Chip-Seq_MCF-7_Human1.08410047
112ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08047636
113FOXP3_21729870_ChIP-Seq_TREG_Human1.07223072
114SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.05753713
115TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05443825
116* SOX17_20123909_ChIP-Seq_XEN_Mouse1.05283445
117PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04925252
118EZH2_22144423_ChIP-Seq_EOC_Human1.04471687
119WT1_19549856_ChIP-ChIP_CCG9911_Human1.04459799
120HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.03561401
121CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03490496
122* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.03248480
123SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01675575
124CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01549920
125MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.00743260
126CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00541128
127* RING1B_27294783_Chip-Seq_ESCs_Mouse1.00208151
128EOMES_21245162_ChIP-Seq_HESCs_Human0.99530264
129NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98023041
130* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97931880
131ELK1_19687146_ChIP-ChIP_HELA_Human0.97630209
132HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97174820
133* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.96299736
134SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95585967
135* RNF2_27304074_Chip-Seq_ESCs_Mouse0.95562366
136NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95494875
137ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94511336
138NANOG_18692474_ChIP-Seq_MEFs_Mouse0.92812405
139TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92776888
140SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92221586
141E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89951003
142KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89370485
143PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88860357
144POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.88089595
145SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86875048

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy6.28334570
2MP0003123_paternal_imprinting5.87268393
3MP0003693_abnormal_embryo_hatching4.18053673
4MP0003122_maternal_imprinting3.92465778
5MP0003705_abnormal_hypodermis_morpholog3.55629012
6MP0000516_abnormal_urinary_system3.41404581
7MP0005367_renal/urinary_system_phenotyp3.41404581
8MP0010030_abnormal_orbit_morphology3.38737551
9MP0004957_abnormal_blastocyst_morpholog3.25970355
10MP0003121_genomic_imprinting3.24416750
11MP0003111_abnormal_nucleus_morphology2.76230228
12MP0004084_abnormal_cardiac_muscle2.56660628
13MP0005076_abnormal_cell_differentiation2.52064539
14MP0003221_abnormal_cardiomyocyte_apopto2.51535228
15* MP0002086_abnormal_extraembryonic_tissu2.50682600
16MP0003566_abnormal_cell_adhesion2.50142336
17MP0003077_abnormal_cell_cycle2.42770882
18MP0004272_abnormal_basement_membrane2.39085800
19* MP0001730_embryonic_growth_arrest2.38914459
20* MP0005380_embryogenesis_phenotype2.31734682
21* MP0001672_abnormal_embryogenesis/_devel2.31734682
22* MP0003984_embryonic_growth_retardation2.31137836
23* MP0003567_abnormal_fetal_cardiomyocyte2.30172215
24* MP0002088_abnormal_embryonic_growth/wei2.28331505
25MP0003718_maternal_effect2.18029762
26* MP0004264_abnormal_extraembryonic_tissu2.14392281
27* MP0001697_abnormal_embryo_size2.06463650
28MP0004197_abnormal_fetal_growth/weight/2.01850611
29MP0010094_abnormal_chromosome_stability1.98406471
30MP0009840_abnormal_foam_cell1.98240931
31MP0003942_abnormal_urinary_system1.97028648
32MP0002751_abnormal_autonomic_nervous1.94169334
33MP0002837_dystrophic_cardiac_calcinosis1.91650035
34MP0000049_abnormal_middle_ear1.88016882
35MP0000534_abnormal_ureter_morphology1.83913750
36MP0010352_gastrointestinal_tract_polyps1.80819484
37MP0008932_abnormal_embryonic_tissue1.80390470
38MP0005623_abnormal_meninges_morphology1.76869929
39* MP0002080_prenatal_lethality1.75326791
40* MP0002084_abnormal_developmental_patter1.75219635
41MP0002249_abnormal_larynx_morphology1.69025479
42MP0000750_abnormal_muscle_regeneration1.60658060
43MP0008438_abnormal_cutaneous_collagen1.60341983
44MP0000013_abnormal_adipose_tissue1.59625950
45MP0008007_abnormal_cellular_replicative1.57770600
46MP0004215_abnormal_myocardial_fiber1.56959600
47MP0002638_abnormal_pupillary_reflex1.55004215
48MP0008775_abnormal_heart_ventricle1.54699881
49* MP0000350_abnormal_cell_proliferation1.52894963
50MP0010234_abnormal_vibrissa_follicle1.52653211
51MP0003119_abnormal_digestive_system1.50666631
52MP0002697_abnormal_eye_size1.50281246
53MP0000537_abnormal_urethra_morphology1.42708088
54MP0005023_abnormal_wound_healing1.39410992
55MP0009250_abnormal_appendicular_skeleto1.38269580
56* MP0002085_abnormal_embryonic_tissue1.37626790
57MP0004510_myositis1.30394605
58MP0003935_abnormal_craniofacial_develop1.28088572
59MP0009672_abnormal_birth_weight1.27870763
60MP0009333_abnormal_splenocyte_physiolog1.25261367
61MP0001293_anophthalmia1.22997276
62MP0005646_abnormal_pituitary_gland1.21967503
63MP0000747_muscle_weakness1.21098200
64MP0000762_abnormal_tongue_morphology1.21084305
65MP0009053_abnormal_anal_canal1.19997148
66MP0005330_cardiomyopathy1.16107822
67MP0003115_abnormal_respiratory_system1.14370957
68MP0006138_congestive_heart_failure1.14225688
69MP0000647_abnormal_sebaceous_gland1.14173654
70MP0010678_abnormal_skin_adnexa1.12981737
71MP0000462_abnormal_digestive_system1.12818818
72MP0001286_abnormal_eye_development1.12537033
73MP0002009_preneoplasia1.12493361
74MP0003283_abnormal_digestive_organ1.11159475
75MP0002932_abnormal_joint_morphology1.10172932
76MP0001346_abnormal_lacrimal_gland1.09454502
77* MP0000428_abnormal_craniofacial_morphol1.09308870
78MP0003878_abnormal_ear_physiology1.09192915
79MP0005377_hearing/vestibular/ear_phenot1.09192915
80MP0000566_synostosis1.07576994
81MP0010307_abnormal_tumor_latency1.07391103
82MP0000383_abnormal_hair_follicle1.06877306
83MP0004085_abnormal_heartbeat1.06396225
84MP0002269_muscular_atrophy1.05122322
85MP0005275_abnormal_skin_tensile1.04717910
86MP0008260_abnormal_autophagy1.04610034
87MP0000003_abnormal_adipose_tissue1.03066132
88MP0000538_abnormal_urinary_bladder1.02013448
89MP0004036_abnormal_muscle_relaxation1.01348576
90MP0001340_abnormal_eyelid_morphology1.00185499
91MP0003137_abnormal_impulse_conducting0.99901995
92MP0010368_abnormal_lymphatic_system0.99642850
93* MP0003937_abnormal_limbs/digits/tail_de0.99575972
94MP0009384_cardiac_valve_regurgitation0.99529786
95MP0009703_decreased_birth_body0.99315698
96MP0005187_abnormal_penis_morphology0.98240087
97MP0005503_abnormal_tendon_morphology0.97204204
98MP0003385_abnormal_body_wall0.97109373
99MP0005384_cellular_phenotype0.93943912
100MP0001756_abnormal_urination0.91235919
101MP0000751_myopathy0.89808070
102MP0002233_abnormal_nose_morphology0.89595756
103* MP0002925_abnormal_cardiovascular_devel0.89014605
104MP0004133_heterotaxia0.87125341
105MP0005621_abnormal_cell_physiology0.85991093
106MP0003890_abnormal_embryonic-extraembry0.85335270
107MP0000465_gastrointestinal_hemorrhage0.84209880
108MP0005197_abnormal_uvea_morphology0.83923449
109MP0008057_abnormal_DNA_replication0.83764628
110MP0003091_abnormal_cell_migration0.83668410
111MP0003453_abnormal_keratinocyte_physiol0.83228248
112MP0001915_intracranial_hemorrhage0.83161773
113MP0002796_impaired_skin_barrier0.82878231
114MP0003938_abnormal_ear_development0.82875588
115MP0000749_muscle_degeneration0.82847035
116MP0002092_abnormal_eye_morphology0.82505494
117MP0002653_abnormal_ependyma_morphology0.82302977
118MP0002109_abnormal_limb_morphology0.82050248
119MP0005083_abnormal_biliary_tract0.80805887
120MP0004233_abnormal_muscle_weight0.79558750
121* MP0000266_abnormal_heart_morphology0.78785902
122MP0005257_abnormal_intraocular_pressure0.78133938
123* MP0002127_abnormal_cardiovascular_syste0.78039179
124MP0003315_abnormal_perineum_morphology0.77678006
125MP0003786_premature_aging0.77276577
126* MP0003861_abnormal_nervous_system0.76685252
127MP0003943_abnormal_hepatobiliary_system0.76562682
128* MP0004087_abnormal_muscle_fiber0.76149928
129* MP0010630_abnormal_cardiac_muscle0.74124882
130MP0003755_abnormal_palate_morphology0.73715648
131MP0008770_decreased_survivor_rate0.73532914
132MP0006054_spinal_hemorrhage0.72500194
133MP0002160_abnormal_reproductive_system0.70629512
134MP0002111_abnormal_tail_morphology0.70106841
135MP0005451_abnormal_body_composition0.70065341
136MP0002116_abnormal_craniofacial_bone0.69780371
137MP0000627_abnormal_mammary_gland0.69714714
138MP0005193_abnormal_anterior_eye0.69449057
139MP0003279_aneurysm0.68646531
140MP0001727_abnormal_embryo_implantation0.67744151
141MP0008877_abnormal_DNA_methylation0.67607328
142MP0000377_abnormal_hair_follicle0.66458959
143MP0002972_abnormal_cardiac_muscle0.65493760
144* MP0001614_abnormal_blood_vessel0.64391285
145MP0004019_abnormal_vitamin_homeostasis0.64108548
146MP0000358_abnormal_cell_content/0.63188656
147* MP0005385_cardiovascular_system_phenoty0.62241101
148* MP0001544_abnormal_cardiovascular_syste0.62241101
149MP0003941_abnormal_skin_development0.61551527
150MP0000733_abnormal_muscle_development0.60485438

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber splitting (HP:0003555)5.53390920
2Pili torti (HP:0003777)5.05328319
3Myelomeningocele (HP:0002475)4.65063865
4Selective tooth agenesis (HP:0001592)4.62585523
5Neonatal hypoglycemia (HP:0001998)4.48392660
6Difficulty climbing stairs (HP:0003551)4.35179516
7Asymmetry of the thorax (HP:0001555)4.12426441
8Right ventricular cardiomyopathy (HP:0011663)3.85220015
9Abnormal pancreas size (HP:0012094)3.83405233
10Breast hypoplasia (HP:0003187)3.77720146
11Abnormality of the aortic arch (HP:0012303)3.75836500
12Abnormality of the phalanges of the 2nd finger (HP:0009541)3.69568384
13Abnormal ventriculo-arterial connection (HP:0011563)3.66939375
14Transposition of the great arteries (HP:0001669)3.66939375
15Abnormal connection of the cardiac segments (HP:0011545)3.66939375
16Submucous cleft hard palate (HP:0000176)3.66129900
17Ventricular tachycardia (HP:0004756)3.60881855
18Areflexia of lower limbs (HP:0002522)3.48176000
19Bilateral microphthalmos (HP:0007633)3.40252468
20Impulsivity (HP:0100710)3.39696403
21Birth length less than 3rd percentile (HP:0003561)3.27048032
22Bicornuate uterus (HP:0000813)3.20314703
23Septate vagina (HP:0001153)3.15195793
24Abnormality of the labia minora (HP:0012880)3.13514016
25Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.11593599
26Hypoplastic left heart (HP:0004383)3.08070118
27Cerebral hypomyelination (HP:0006808)3.06420152
28Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.05101421
29Abnormality of the middle phalanges of the toes (HP:0010183)2.95173168
30Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.92626040
31Abnormality of the parietal bone (HP:0002696)2.91412455
32Partial duplication of the phalanx of hand (HP:0009999)2.90967132
33Multiple enchondromatosis (HP:0005701)2.90334949
34Abnormality of the 2nd finger (HP:0004100)2.90276943
35Increased connective tissue (HP:0009025)2.89685219
36Short nail (HP:0001799)2.88486566
37Hypothermia (HP:0002045)2.88470381
38Abnormality of the phalanges of the 5th finger (HP:0004213)2.88416142
39Abnormal number of incisors (HP:0011064)2.86582142
40Preauricular pit (HP:0004467)2.83543568
41Periauricular skin pits (HP:0100277)2.83543568
42Abnormality of the umbilical cord (HP:0010881)2.82224504
43Micronodular cirrhosis (HP:0001413)2.80239663
44Abnormality of the proximal phalanges of the hand (HP:0009834)2.78331176
45Pelvic girdle muscle weakness (HP:0003749)2.77225674
46Abnormal hair laboratory examination (HP:0003328)2.77159580
47Short middle phalanx of the 5th finger (HP:0004220)2.76720398
48Bell-shaped thorax (HP:0001591)2.72834427
49Congenital malformation of the right heart (HP:0011723)2.68781138
50Double outlet right ventricle (HP:0001719)2.68781138
51Absent radius (HP:0003974)2.67710769
52Embryonal renal neoplasm (HP:0011794)2.67473388
53Carpal bone hypoplasia (HP:0001498)2.61559262
54Anal stenosis (HP:0002025)2.59696269
55Abnormal lung lobation (HP:0002101)2.57498593
56Fused cervical vertebrae (HP:0002949)2.56520802
57Progressive muscle weakness (HP:0003323)2.56312028
58Postnatal microcephaly (HP:0005484)2.54677208
59Aplasia involving forearm bones (HP:0009822)2.54173748
60Absent forearm bone (HP:0003953)2.54173748
61Anophthalmia (HP:0000528)2.53454568
62Aplasia/Hypoplasia of the patella (HP:0006498)2.50733886
63Palpitations (HP:0001962)2.50397941
64Cervical subluxation (HP:0003308)2.49994382
65Patent foramen ovale (HP:0001655)2.49285322
66Patellar aplasia (HP:0006443)2.47671423
67Cutaneous finger syndactyly (HP:0010554)2.47589716
68Shoulder girdle muscle weakness (HP:0003547)2.46937817
69Hyperglycinemia (HP:0002154)2.46575385
70Deviation of the thumb (HP:0009603)2.45761067
71Midline defect of the nose (HP:0004122)2.40465842
72Hyporeflexia of lower limbs (HP:0002600)2.39660686
73Abnormality of the nasolacrimal system (HP:0000614)2.38883513
74Abnormality of the parathyroid morphology (HP:0011766)2.36970412
75Lymphangioma (HP:0100764)2.36217162
76Abnormality of the hip-girdle musculature (HP:0001445)2.33222350
77Abnormality of the musculature of the pelvis (HP:0001469)2.33222350
7811 pairs of ribs (HP:0000878)2.32093432
79Sparse eyelashes (HP:0000653)2.32084215
80Aplasia/hypoplasia of the humerus (HP:0006507)2.31317740
81Rough bone trabeculation (HP:0100670)2.30659366
82Preauricular skin tag (HP:0000384)2.30302893
83Short middle phalanx of finger (HP:0005819)2.29754093
84Aplasia/Hypoplasia of the sacrum (HP:0008517)2.29531263
85Abnormality of the calcaneus (HP:0008364)2.29081311
86Cutaneous syndactyly (HP:0012725)2.27466344
87Exercise-induced muscle cramps (HP:0003710)2.27070465
88Partial duplication of thumb phalanx (HP:0009944)2.26906960
89Diastasis recti (HP:0001540)2.26628839
90Ankle contracture (HP:0006466)2.26604144
91Hypoplastic heart (HP:0001961)2.26407303
92Sudden death (HP:0001699)2.26208833
93Shallow orbits (HP:0000586)2.22919659
94Short 5th finger (HP:0009237)2.22478534
95Premature rupture of membranes (HP:0001788)2.21437123
96Abnormality of the lacrimal duct (HP:0011481)2.20007903
97Bifid tongue (HP:0010297)2.19941300
98Skin pits (HP:0100276)2.19490346
99Premature ovarian failure (HP:0008209)2.18774768
100Increased mean platelet volume (HP:0011877)2.16546044
101Gout (HP:0001997)2.16316035
102Muscle fibrillation (HP:0010546)2.15322344
103Missing ribs (HP:0000921)2.14148977
104Morphological abnormality of the middle ear (HP:0008609)2.13224915
105Orthostatic hypotension (HP:0001278)2.11902807
106Impaired pain sensation (HP:0007328)2.10447939
107Abnormality of pain sensation (HP:0010832)2.10447939
108Truncus arteriosus (HP:0001660)2.09863761
109Sparse lateral eyebrow (HP:0005338)2.09731094
110Preaxial foot polydactyly (HP:0001841)2.09478426
111Esophageal varix (HP:0002040)2.09415231
112Fibular aplasia (HP:0002990)2.06959366
113Hypoplastic toenails (HP:0001800)2.06731588
114Short hallux (HP:0010109)2.06465296
115Rimmed vacuoles (HP:0003805)2.06245788
116Annular pancreas (HP:0001734)2.05174687
117Short humerus (HP:0005792)2.05110240
118Coronal craniosynostosis (HP:0004440)2.05016718
119Atresia of the external auditory canal (HP:0000413)2.04157956
120Ectopic anus (HP:0004397)2.03495740
121Short clavicles (HP:0000894)2.01909931
122Syncope (HP:0001279)2.00968442
123Abnormality of the phalanges of the hallux (HP:0010057)2.00731060
124Meningocele (HP:0002435)2.00514888
125Hypoplastic pelvis (HP:0008839)1.99122709
126Oral leukoplakia (HP:0002745)1.96794458
127Enlarged penis (HP:0000040)1.96741483
128Ureteral duplication (HP:0000073)1.96408397
129Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.96345537
130Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.96180880
131Abnormal umbilical cord blood vessels (HP:0011403)1.95698909
132Single umbilical artery (HP:0001195)1.95698909
133Abnormality of the fetal cardiovascular system (HP:0010948)1.95698909
134Ventricular fibrillation (HP:0001663)1.95270482
135Secondary amenorrhea (HP:0000869)1.94295562
136Difficulty running (HP:0009046)1.94235734
137Oligodactyly (hands) (HP:0001180)1.92936946
138Atrioventricular block (HP:0001678)1.91591566
139Bundle branch block (HP:0011710)1.91160697
140Persistence of primary teeth (HP:0006335)1.90877321
141Renal duplication (HP:0000075)1.90470352
142Segmental peripheral demyelination/remyelination (HP:0003481)1.90103185
143Colon cancer (HP:0003003)1.88871481
144Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.88035490
145Neonatal death (HP:0003811)1.87579146
146Abnormal platelet volume (HP:0011876)1.86845228
147Anteriorly placed anus (HP:0001545)1.86710726
148Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86197441
149Abnormal autonomic nervous system physiology (HP:0012332)1.86013719
150Confusion (HP:0001289)1.85953521
151Bronchomalacia (HP:0002780)1.85558723
152Nephroblastoma (Wilms tumor) (HP:0002667)1.85468916
153CNS hypomyelination (HP:0003429)1.85449165
154Skin tags (HP:0010609)1.84947090
155Short 1st metacarpal (HP:0010034)1.84354608
156Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.84354608
157Hyperglycinuria (HP:0003108)1.83917581
158Proximal placement of thumb (HP:0009623)1.83725731
159Choanal stenosis (HP:0000452)1.82878724
160Vitreoretinal degeneration (HP:0000655)1.82532124
161Aplasia/Hypoplasia of the hallux (HP:0008362)1.81919202
162Shawl scrotum (HP:0000049)1.81393909
163Overriding aorta (HP:0002623)1.80677325
164Slender long bone (HP:0003100)1.79930367
165Broad toe (HP:0001837)1.79608884
166Hyperacusis (HP:0010780)1.79389986
167Tetraplegia (HP:0002445)1.79305909
168Oligodactyly (HP:0012165)1.78115970
169Aplasia/Hypoplasia of the clavicles (HP:0006710)1.77791422
170Broad distal phalanx of finger (HP:0009836)1.77080073
171Abnormality of the distal phalanx of the thumb (HP:0009617)1.76011594
172Abnormal trabecular bone morphology (HP:0100671)1.75813826
173Spinal cord compression (HP:0002176)1.75790909
174Skull defect (HP:0001362)1.73343847
175Abnormal vertebral ossification (HP:0100569)1.73176425
176Delayed CNS myelination (HP:0002188)1.73067762
177Anal atresia (HP:0002023)1.72866324
178Abnormal tarsal ossification (HP:0008369)1.71008712
179Hypoplasia of the iris (HP:0007676)1.69712317
180Underdeveloped supraorbital ridges (HP:0009891)1.69528852
181High anterior hairline (HP:0009890)1.69523707
182Short phalanx of the thumb (HP:0009660)1.68863785

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.85996976
2WEE14.04280905
3TSSK63.48887205
4STK103.05401483
5RPS6KB22.94984367
6NEK12.91588714
7FGFR22.85712793
8AKT32.63274847
9MST42.57968229
10ALK2.33309322
11NEK22.26878485
12LATS12.23211397
13MAP3K102.21081401
14DMPK2.16276237
15TRIB32.14511315
16PRKG22.10498122
17LATS22.04547968
18PLK32.03024206
19PNCK2.01227795
20EPHA22.00167848
21LIMK12.00165466
22TIE11.97824418
23PKN21.93860749
24DDR21.86844704
25EIF2AK11.78406374
26PDK21.77466606
27SCYL21.76983161
28PIK3CA1.74579249
29MAP3K81.73163378
30TRIM281.71677582
31TTK1.71555932
32LRRK21.66396520
33BRSK21.63543946
34TYRO31.60557889
35STK41.58280805
36CDK71.52722159
37MKNK11.50995597
38RET1.45236490
39SMG11.42188799
40PBK1.41411259
41PLK11.41219463
42MKNK21.41018777
43CDK121.40908256
44PRKCI1.34792876
45ICK1.34058025
46STK161.31864107
47CDC71.30092175
48MAP2K21.29183072
49MARK31.28181615
50FLT31.26520762
51ARAF1.23308701
52PTK21.22064962
53* PLK41.21956201
54GRK61.12869429
55VRK21.11161260
56BRSK11.10255705
57PAK41.07117939
58EEF2K1.06945466
59NME21.03534573
60SRPK11.00951370
61AURKA0.98490105
62AURKB0.97991673
63STK38L0.94026024
64RIPK10.93494919
65BRD40.92512154
66STK30.92131202
67EPHB20.91626683
68ERBB30.90586023
69PAK10.85653051
70ACVR1B0.85623633
71PASK0.83443063
72MAP3K90.82921941
73MAP2K10.82064059
74BRAF0.81230750
75PAK20.80774054
76CSNK1E0.80552860
77FER0.77071577
78MAP3K30.75038476
79MYLK0.74972822
80AKT20.73557227
81PTK60.73063816
82MTOR0.71781219
83CHEK10.71239407
84CDC42BPA0.68985887
85PRKD30.66049057
86MATK0.65679186
87DAPK30.64392875
88TLK10.64131727
89ATR0.63502060
90MAP2K30.61573886
91BCKDK0.60251954
92BCR0.60041296
93FGR0.59398637
94EIF2AK30.59302678
95PLK20.57425969
96PAK30.56808528
97CSNK1G30.56375938
98RAF10.56226237
99MET0.56094222
100MAP3K110.55881246
101PDGFRA0.55714148
102CDK20.52597758
103MAP3K50.51677831
104KSR20.51522415
105CSNK1G10.50936766
106ROCK10.49197940
107OBSCN0.48756593
108MELK0.47503944
109CHEK20.46939755
110PDK30.45793192
111PDK40.45793192
112EIF2AK20.45169218
113ILK0.44899112
114KSR10.44822741
115CDK40.44349700
116EPHB10.44304835
117STK240.44114433
118BMPR1B0.42777306
119TAF10.42429363
120KDR0.42194107
121CLK10.42191366
122PRKAA20.42156393
123FGFR10.41801342
124PDPK10.41079530
125NME10.39925579
126PRKD10.39914499
127TGFBR10.39134501
128CSNK2A10.37575689
129CSNK1A1L0.36600340
130CDK10.36477604
131ROCK20.36113449
132MAPKAPK30.35370387
133TESK20.34596598
134RPS6KA40.34193948
135DYRK30.33965796
136CSNK1G20.32670386
137ZAK0.31407372
138PIM20.30087497
139NTRK10.29881778
140CSNK2A20.28036943
141ATM0.27603591
142CAMK2B0.27376035

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.72751488
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.62261214
3RNA transport_Homo sapiens_hsa030133.80326226
4RNA polymerase_Homo sapiens_hsa030203.73503837
5Proteasome_Homo sapiens_hsa030503.31883208
6Spliceosome_Homo sapiens_hsa030402.64963532
7Cell cycle_Homo sapiens_hsa041102.60271224
8Sulfur relay system_Homo sapiens_hsa041222.40334321
9Nucleotide excision repair_Homo sapiens_hsa034202.08433688
10Cardiac muscle contraction_Homo sapiens_hsa042602.07779489
11Hippo signaling pathway_Homo sapiens_hsa043901.97916663
12Folate biosynthesis_Homo sapiens_hsa007901.97270054
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.87789370
14DNA replication_Homo sapiens_hsa030301.85099270
15Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.84998850
16Pyrimidine metabolism_Homo sapiens_hsa002401.83421956
17Non-homologous end-joining_Homo sapiens_hsa034501.81317132
18Oocyte meiosis_Homo sapiens_hsa041141.72486565
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67314771
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.62775241
21Parkinsons disease_Homo sapiens_hsa050121.61174755
22Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.50421779
23Biosynthesis of amino acids_Homo sapiens_hsa012301.50141211
24p53 signaling pathway_Homo sapiens_hsa041151.49205980
25Pentose phosphate pathway_Homo sapiens_hsa000301.45312434
26Tight junction_Homo sapiens_hsa045301.44663171
27Vitamin digestion and absorption_Homo sapiens_hsa049771.39272265
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.37815202
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.33378757
30One carbon pool by folate_Homo sapiens_hsa006701.33257506
31Basal transcription factors_Homo sapiens_hsa030221.29913563
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.28417279
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26123231
34mRNA surveillance pathway_Homo sapiens_hsa030151.22115796
35Thyroid cancer_Homo sapiens_hsa052161.22066866
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.21782876
37Huntingtons disease_Homo sapiens_hsa050161.21249519
38Protein digestion and absorption_Homo sapiens_hsa049741.21161387
39Mismatch repair_Homo sapiens_hsa034301.20293199
40Ribosome_Homo sapiens_hsa030101.19938770
41Epstein-Barr virus infection_Homo sapiens_hsa051691.19632236
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19186831
43Purine metabolism_Homo sapiens_hsa002301.17636171
44Antigen processing and presentation_Homo sapiens_hsa046121.16449624
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.13887161
46Glycerophospholipid metabolism_Homo sapiens_hsa005641.12414776
47Pyruvate metabolism_Homo sapiens_hsa006201.11744856
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10929458
49Renal cell carcinoma_Homo sapiens_hsa052111.09895527
50RNA degradation_Homo sapiens_hsa030181.09341984
51Oxidative phosphorylation_Homo sapiens_hsa001901.09072415
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.08311799
53Proteoglycans in cancer_Homo sapiens_hsa052051.07067877
54Steroid biosynthesis_Homo sapiens_hsa001001.06646348
55Adherens junction_Homo sapiens_hsa045201.05092360
56Tyrosine metabolism_Homo sapiens_hsa003501.04986911
57Base excision repair_Homo sapiens_hsa034101.02781377
58Fanconi anemia pathway_Homo sapiens_hsa034601.02539711
59Melanogenesis_Homo sapiens_hsa049160.97287932
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.95387235
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.94371753
62Galactose metabolism_Homo sapiens_hsa000520.91233818
63TGF-beta signaling pathway_Homo sapiens_hsa043500.89664697
64MicroRNAs in cancer_Homo sapiens_hsa052060.87044960
65* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85206670
66Homologous recombination_Homo sapiens_hsa034400.84829762
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83313571
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83187733
69Fatty acid elongation_Homo sapiens_hsa000620.80762834
70Carbon metabolism_Homo sapiens_hsa012000.79074259
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78557066
72HIF-1 signaling pathway_Homo sapiens_hsa040660.74839677
73Hedgehog signaling pathway_Homo sapiens_hsa043400.74365714
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74259310
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.74052943
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72226491
77Regulation of autophagy_Homo sapiens_hsa041400.69260810
78Alzheimers disease_Homo sapiens_hsa050100.68700157
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66692083
80Fructose and mannose metabolism_Homo sapiens_hsa000510.66260249
81Endometrial cancer_Homo sapiens_hsa052130.64652373
82Axon guidance_Homo sapiens_hsa043600.64393735
83Nitrogen metabolism_Homo sapiens_hsa009100.62853539
84mTOR signaling pathway_Homo sapiens_hsa041500.62846913
85Dilated cardiomyopathy_Homo sapiens_hsa054140.61795819
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61268668
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60165606
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59310106
89Viral carcinogenesis_Homo sapiens_hsa052030.58978632
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58070287
91N-Glycan biosynthesis_Homo sapiens_hsa005100.56833937
92Sulfur metabolism_Homo sapiens_hsa009200.55924937
93Prostate cancer_Homo sapiens_hsa052150.54748126
94Small cell lung cancer_Homo sapiens_hsa052220.54667889
95Focal adhesion_Homo sapiens_hsa045100.53535745
96HTLV-I infection_Homo sapiens_hsa051660.52442271
97Dorso-ventral axis formation_Homo sapiens_hsa043200.49902133
98Basal cell carcinoma_Homo sapiens_hsa052170.48990915
99Fatty acid metabolism_Homo sapiens_hsa012120.48846077
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47014894
101Arginine and proline metabolism_Homo sapiens_hsa003300.46544102
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46014927
103Bladder cancer_Homo sapiens_hsa052190.44616197
104Amoebiasis_Homo sapiens_hsa051460.42783472
105ECM-receptor interaction_Homo sapiens_hsa045120.42760909
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42675748
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41655690
108Vibrio cholerae infection_Homo sapiens_hsa051100.41468512
109Lysine degradation_Homo sapiens_hsa003100.40781462
110Notch signaling pathway_Homo sapiens_hsa043300.39439021
111Estrogen signaling pathway_Homo sapiens_hsa049150.37918017
112FoxO signaling pathway_Homo sapiens_hsa040680.37537832
113Selenocompound metabolism_Homo sapiens_hsa004500.36213010
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36071741
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34792729
116Wnt signaling pathway_Homo sapiens_hsa043100.34715604
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33787434
118Protein export_Homo sapiens_hsa030600.32857441
119Glycerolipid metabolism_Homo sapiens_hsa005610.31461055
120Phenylalanine metabolism_Homo sapiens_hsa003600.30892345
121Rap1 signaling pathway_Homo sapiens_hsa040150.28897518
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28650178
123Pathways in cancer_Homo sapiens_hsa052000.28347215
124VEGF signaling pathway_Homo sapiens_hsa043700.28109940
125Acute myeloid leukemia_Homo sapiens_hsa052210.27605117
126cAMP signaling pathway_Homo sapiens_hsa040240.26098713
127AMPK signaling pathway_Homo sapiens_hsa041520.25809027
128Linoleic acid metabolism_Homo sapiens_hsa005910.25734844
129Cyanoamino acid metabolism_Homo sapiens_hsa004600.24643662
130Endocytosis_Homo sapiens_hsa041440.22341772
131Colorectal cancer_Homo sapiens_hsa052100.20997703
132Glucagon signaling pathway_Homo sapiens_hsa049220.19361359
133Gap junction_Homo sapiens_hsa045400.17959459
134Prion diseases_Homo sapiens_hsa050200.16435611
135Insulin signaling pathway_Homo sapiens_hsa049100.15306404
136Chronic myeloid leukemia_Homo sapiens_hsa052200.15303582

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