HAO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of three related genes that have 2-hydroxyacid oxidase activity. The encoded protein localizes to the peroxisome has the highest activity toward the substrate 2-hydroxypalmitate. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)9.10521660
2omega-hydroxylase P450 pathway (GO:0097267)8.71440980
3complement activation, alternative pathway (GO:0006957)8.37584008
4regulation of protein activation cascade (GO:2000257)8.13682051
5regulation of fibrinolysis (GO:0051917)7.97524649
6lysine metabolic process (GO:0006553)7.75399794
7lysine catabolic process (GO:0006554)7.75399794
8regulation of complement activation (GO:0030449)7.64897309
9negative regulation of fibrinolysis (GO:0051918)7.46800813
10drug transmembrane transport (GO:0006855)7.29482072
11urate metabolic process (GO:0046415)7.11802279
12cysteine metabolic process (GO:0006534)6.73164112
13glyoxylate metabolic process (GO:0046487)6.61430693
14drug transport (GO:0015893)6.36111358
15fibrinolysis (GO:0042730)6.32875724
16peptidyl-glutamic acid carboxylation (GO:0017187)6.29401737
17protein carboxylation (GO:0018214)6.29401737
18aromatic amino acid family catabolic process (GO:0009074)6.18441310
19nitrogen cycle metabolic process (GO:0071941)6.17169942
20L-phenylalanine catabolic process (GO:0006559)6.14765112
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.14765112
22blood coagulation, intrinsic pathway (GO:0007597)6.09642314
23L-phenylalanine metabolic process (GO:0006558)6.08766986
24erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.08766986
25tryptophan catabolic process (GO:0006569)6.02638662
26indole-containing compound catabolic process (GO:0042436)6.02638662
27indolalkylamine catabolic process (GO:0046218)6.02638662
28organic cation transport (GO:0015695)5.89295721
29cellular ketone body metabolic process (GO:0046950)5.76044829
30oxidative demethylation (GO:0070989)5.75760771
31regulation of triglyceride catabolic process (GO:0010896)5.73172689
32tryptophan metabolic process (GO:0006568)5.64845334
33kynurenine metabolic process (GO:0070189)5.57401659
34ethanol metabolic process (GO:0006067)5.51596614
35aminoglycoside antibiotic metabolic process (GO:0030647)5.48601451
36phenylpropanoid metabolic process (GO:0009698)5.46291581
37phosphate ion transport (GO:0006817)5.42794221
38short-chain fatty acid metabolic process (GO:0046459)5.38103366
39protein activation cascade (GO:0072376)5.33042037
40glycine metabolic process (GO:0006544)5.31769078
41response to mercury ion (GO:0046689)5.29133243
42aspartate family amino acid catabolic process (GO:0009068)5.25910766
43sulfur amino acid catabolic process (GO:0000098)5.23772521
44regulation of plasminogen activation (GO:0010755)5.22251896
45complement activation (GO:0006956)5.17030573
46serine family amino acid catabolic process (GO:0009071)5.13877054
47homocysteine metabolic process (GO:0050667)5.12686365
48quaternary ammonium group transport (GO:0015697)5.07987353
49triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.07611718
50drug catabolic process (GO:0042737)5.06139212
51acute-phase response (GO:0006953)5.05238390
52complement activation, classical pathway (GO:0006958)5.03250792
53ketone body metabolic process (GO:1902224)4.98291534
542-oxoglutarate metabolic process (GO:0006103)4.96798490
55amino-acid betaine metabolic process (GO:0006577)4.92819352
56phosphate ion transmembrane transport (GO:0035435)4.91567975
57regulation of humoral immune response (GO:0002920)4.88336805
58opsonization (GO:0008228)4.86066909
59negative regulation of protein activation cascade (GO:2000258)4.77284788
60negative regulation of blood coagulation (GO:0030195)4.75539855
61negative regulation of hemostasis (GO:1900047)4.75539855
62fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.72827773
63glutamate metabolic process (GO:0006536)4.70044927
64S-adenosylmethionine metabolic process (GO:0046500)4.66989271
65acylglycerol homeostasis (GO:0055090)4.66109381
66triglyceride homeostasis (GO:0070328)4.66109381
67imidazole-containing compound metabolic process (GO:0052803)4.61002702
68cellular modified amino acid catabolic process (GO:0042219)4.56457585
69bile acid and bile salt transport (GO:0015721)4.54864962
70aromatic amino acid family metabolic process (GO:0009072)4.52662914
71tricarboxylic acid metabolic process (GO:0072350)4.52527755
72valine metabolic process (GO:0006573)4.51181085
73serine family amino acid metabolic process (GO:0009069)4.48407352
74flavonoid metabolic process (GO:0009812)4.45733185
75branched-chain amino acid metabolic process (GO:0009081)4.40810887
76positive regulation of lipoprotein lipase activity (GO:0051006)4.40223755
77positive regulation of triglyceride lipase activity (GO:0061365)4.40223755
78benzene-containing compound metabolic process (GO:0042537)4.37891155
79cytolysis (GO:0019835)4.35605333
80negative regulation of wound healing (GO:0061045)4.35104328
81excretion (GO:0007588)4.33630702
82negative regulation of coagulation (GO:0050819)4.31696631
83fatty acid beta-oxidation (GO:0006635)4.30939414
84amino-acid betaine transport (GO:0015838)4.30241924
85carnitine transport (GO:0015879)4.30241924
86alpha-amino acid catabolic process (GO:1901606)4.29852600
87carnitine metabolic process (GO:0009437)4.28375723
88acetyl-CoA metabolic process (GO:0006084)4.28138950
89cellular amino acid catabolic process (GO:0009063)4.26117838
90indolalkylamine metabolic process (GO:0006586)4.22189737
91exogenous drug catabolic process (GO:0042738)4.21312876
92hormone catabolic process (GO:0042447)4.21015748
93vitamin D metabolic process (GO:0042359)4.17799922
94phospholipid efflux (GO:0033700)4.17420290
95cellular glucuronidation (GO:0052695)4.14790260
96arginine metabolic process (GO:0006525)4.13636819
97alkaloid metabolic process (GO:0009820)4.13206005
98fructose metabolic process (GO:0006000)4.12904669
99bile acid biosynthetic process (GO:0006699)4.11825074
100plasma lipoprotein particle remodeling (GO:0034369)4.10973282
101protein-lipid complex remodeling (GO:0034368)4.10973282
102macromolecular complex remodeling (GO:0034367)4.10973282
103nonribosomal peptide biosynthetic process (GO:0019184)4.09858230
104negative regulation of complement activation (GO:0045916)4.09646664
105glucuronate metabolic process (GO:0019585)4.01787138
106uronic acid metabolic process (GO:0006063)4.01787138
107glucocorticoid biosynthetic process (GO:0006704)3.99038515
108alpha-linolenic acid metabolic process (GO:0036109)3.99021360
109amine catabolic process (GO:0009310)3.99014016
110cellular biogenic amine catabolic process (GO:0042402)3.99014016
111branched-chain amino acid catabolic process (GO:0009083)3.95777006
112killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.95630239
113disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.95630239
114serine family amino acid biosynthetic process (GO:0009070)3.93819455
115* fatty acid oxidation (GO:0019395)3.93291815
116cholesterol efflux (GO:0033344)3.92909125
117renal absorption (GO:0070293)3.88230252
118positive regulation of hemostasis (GO:1900048)3.87691067
119positive regulation of blood coagulation (GO:0030194)3.87691067
120carboxylic acid catabolic process (GO:0046395)3.86337343
121organic acid catabolic process (GO:0016054)3.86337343
122* lipid oxidation (GO:0034440)3.85559997
123negative regulation of lipase activity (GO:0060192)3.84285391
124response to phenylpropanoid (GO:0080184)3.82757134
125glutathione biosynthetic process (GO:0006750)3.82707769
126acute inflammatory response (GO:0002526)3.80116361
127high-density lipoprotein particle remodeling (GO:0034375)3.78049494
128monocarboxylic acid catabolic process (GO:0072329)3.76286033
129negative regulation of sterol transport (GO:0032372)3.76088420
130negative regulation of cholesterol transport (GO:0032375)3.76088420
131fatty acid catabolic process (GO:0009062)3.75917314
132regulation of cholesterol esterification (GO:0010872)3.74701674
133drug metabolic process (GO:0017144)3.71305451
134positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.66166820
135xenobiotic metabolic process (GO:0006805)3.66061441
136bile acid metabolic process (GO:0008206)3.65639354
137aldehyde catabolic process (GO:0046185)3.62797147
138proline metabolic process (GO:0006560)3.62605751
139steroid catabolic process (GO:0006706)3.62360309
140dicarboxylic acid metabolic process (GO:0043648)3.61330091
141positive regulation of coagulation (GO:0050820)3.57097322
142indole-containing compound metabolic process (GO:0042430)3.55837282
143ethanol oxidation (GO:0006069)3.53700436
144tyrosine metabolic process (GO:0006570)3.53389735
145reverse cholesterol transport (GO:0043691)3.52495203
146metanephric tubule development (GO:0072170)3.49375481
147metanephric nephron tubule development (GO:0072234)3.49375481
148regulation of acute inflammatory response (GO:0002673)3.47458246
149modified amino acid transport (GO:0072337)3.46899163
150positive regulation of lipid catabolic process (GO:0050996)3.46811853
151biotin metabolic process (GO:0006768)3.46583052
152response to growth hormone (GO:0060416)3.45160099
153heme transport (GO:0015886)3.42589871
154regulation of cholesterol homeostasis (GO:2000188)3.39900203
155vitamin transport (GO:0051180)3.37019073
156small molecule catabolic process (GO:0044282)3.35969304
157dicarboxylic acid biosynthetic process (GO:0043650)3.35512245
158glutathione derivative metabolic process (GO:1901685)3.26105868
159glutathione derivative biosynthetic process (GO:1901687)3.26105868
160glutathione metabolic process (GO:0006749)3.25822958
161urea metabolic process (GO:0019627)3.20844193
162urea cycle (GO:0000050)3.20844193
163L-ascorbic acid metabolic process (GO:0019852)3.20718143

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.28398710
2RXR_22158963_ChIP-Seq_LIVER_Mouse7.03666514
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.98673610
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.63236814
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.44512830
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.17088345
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.57552211
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.05691397
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.95866724
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.75222437
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.64025628
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.63370618
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.43963245
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.23486973
15CLOCK_20551151_ChIP-Seq_293T_Human1.99170372
16ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.96879265
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.95030759
18HTT_18923047_ChIP-ChIP_STHdh_Human1.93642243
19CDX2_20551321_ChIP-Seq_CACO-2_Human1.92065363
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.91971913
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.88479050
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83713328
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.68464379
24SOX2_27498859_Chip-Seq_STOMACH_Mouse1.63559956
25CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.57229378
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.56089529
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.51951014
28* HNF4A_19822575_ChIP-Seq_HepG2_Human1.50816622
29NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.50572340
30FOXA2_19822575_ChIP-Seq_HepG2_Human1.49840784
31ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.46900432
32* GATA4_25053715_ChIP-Seq_YYC3_Human1.44983270
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.42416330
34VDR_22108803_ChIP-Seq_LS180_Human1.34250620
35LXR_22292898_ChIP-Seq_THP-1_Human1.28538302
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23204589
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21919332
38ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18417315
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.18214815
40GATA6_25053715_ChIP-Seq_YYC3_Human1.16252551
41AR_21909140_ChIP-Seq_LNCAP_Human1.12511926
42GATA1_22025678_ChIP-Seq_K562_Human1.08569474
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07776743
44RACK7_27058665_Chip-Seq_MCF-7_Human1.06301036
45BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.05222706
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05137683
47PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00605566
48SOX2_20726797_ChIP-Seq_SW620_Human1.00503744
49FOXO3_23340844_ChIP-Seq_DLD1_Human0.98902031
50CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97611202
51EGR1_19032775_ChIP-ChIP_M12_Human0.97506792
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96723367
53* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.95552720
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94127788
55* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.93727340
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93450791
57IRF8_22096565_ChIP-ChIP_GC-B_Human0.91620363
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90877076
59RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90552661
60NFE2_27457419_Chip-Seq_LIVER_Mouse0.90032312
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89307228
62ZNF263_19887448_ChIP-Seq_K562_Human0.88698358
63* HNFA_21074721_ChIP-Seq_CACO-2_Human0.87540723
64ERG_21242973_ChIP-ChIP_JURKAT_Human0.85922688
65STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85874557
66* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.85428186
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84980898
68RXRA_24833708_ChIP-Seq_LIVER_Mouse0.84836621
69* PHF8_20622853_ChIP-Seq_HELA_Human0.83661727
70PPAR_26484153_Chip-Seq_NCI-H1993_Human0.82295247
71SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82262574
72BCAT_22108803_ChIP-Seq_LS180_Human0.81280502
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.78494303
74* GATA6_21074721_ChIP-Seq_CACO-2_Human0.77605810
75CBP_21632823_ChIP-Seq_H3396_Human0.76918761
76FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76464148
77MYC_19915707_ChIP-ChIP_AK7_Human0.75937082
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.75835164
79SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.74290312
80SOX2_21211035_ChIP-Seq_LN229_Human0.74056591
81IRF1_19129219_ChIP-ChIP_H3396_Human0.73105309
82EZH2_27294783_Chip-Seq_NPCs_Mouse0.72540138
83FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.71927533
84* NFYA_21822215_ChIP-Seq_K562_Human0.71552840
85* AR_20517297_ChIP-Seq_VCAP_Human0.71001852
86AUTS2_25519132_ChIP-Seq_293T-REX_Human0.70931907
87GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.70822343
88TBX20_22080862_ChIP-Seq_HEART_Mouse0.70181808
89TBX20_22328084_ChIP-Seq_HEART_Mouse0.70181808
90SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70136582
91GATA2_19941826_ChIP-Seq_K562_Human0.69141963
92NRF2_20460467_ChIP-Seq_MEFs_Mouse0.68794530
93NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.68794530
94PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.68400396
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.67371091
96CEBPB_22108803_ChIP-Seq_LS180_Human0.67034143
97ESR1_20079471_ChIP-ChIP_T-47D_Human0.66526113
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.65877347
99Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.65769973
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.65659169
101CREB1_26743006_Chip-Seq_LNCaP_Human0.65556193
102GATA1_19941826_ChIP-Seq_K562_Human0.65273368
103CDX2_22108803_ChIP-Seq_LS180_Human0.64828891
104CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.64794847
105TAF2_19829295_ChIP-Seq_ESCs_Human0.64695320
106* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.63882625
107SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.63494584
108ETV2_25802403_ChIP-Seq_MESCs_Mouse0.62467053
109FOXA1_25552417_ChIP-Seq_VCAP_Human0.62419505
110PIAS1_25552417_ChIP-Seq_VCAP_Human0.62318107
111SUZ12_27294783_Chip-Seq_NPCs_Mouse0.62261490
112* TP53_18474530_ChIP-ChIP_U2OS_Human0.62081066
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.61991509
114* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.61899733
115RAC3_21632823_ChIP-Seq_H3396_Human0.61889731
116SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.61525380
117CRX_20693478_ChIP-Seq_RETINA_Mouse0.61171395
118ESET_19884257_ChIP-Seq_ESCs_Mouse0.61135831
119RXR_22108803_ChIP-Seq_LS180_Human0.60800922
120P63_26484246_Chip-Seq_KERATINOCYTES_Human0.60068663
121P53_21459846_ChIP-Seq_SAOS-2_Human0.59465334
122TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.59389361
123KAP1_22055183_ChIP-Seq_ESCs_Mouse0.59241121
124SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.58993296
125ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.58568358
126CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.58493368
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.58353641
128SPI1_20517297_ChIP-Seq_HL60_Human0.58011645
129PCGF2_27294783_Chip-Seq_NPCs_Mouse0.57757576
130ATF3_27146783_Chip-Seq_COLON_Human0.57323639
131EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.57223331
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.56673494
133FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.56567413
134* ETV1_20927104_ChIP-Seq_GIST48_Human0.56567230
135SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.56193986
136OCT4_21477851_ChIP-Seq_ESCs_Mouse0.55977962
137SRY_22984422_ChIP-ChIP_TESTIS_Rat0.55753224
138RUNX1_27457419_Chip-Seq_LIVER_Mouse0.55371029
139SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.55218011
140OCT4_18555785_Chip-Seq_ESCs_Mouse0.55135844
141MYC_19829295_ChIP-Seq_ESCs_Human0.54395568
142ER_23166858_ChIP-Seq_MCF-7_Human0.54314835
143CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.54246517
144ESRRB_18555785_Chip-Seq_ESCs_Mouse0.53851180
145ERG_20517297_ChIP-Seq_VCAP_Human0.52821211
146SMAD1_18555785_Chip-Seq_ESCs_Mouse0.52748785
147GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.52601371
148CTCF_20526341_ChIP-Seq_ESCs_Human0.51337529
149SA1_27219007_Chip-Seq_Bcells_Human0.50760919
150DNAJC2_21179169_ChIP-ChIP_NT2_Human0.50611979
151* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.50375473

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.45451237
2MP0002139_abnormal_hepatobiliary_system6.50982798
3MP0005332_abnormal_amino_acid4.32158894
4MP0008875_abnormal_xenobiotic_pharmacok4.30990679
5MP0004043_abnormal_pH_regulation4.30498324
6MP0005365_abnormal_bile_salt4.18756266
7MP0003195_calcinosis4.15177268
8MP0004019_abnormal_vitamin_homeostasis4.02823671
9MP0005085_abnormal_gallbladder_physiolo3.99079461
10MP0009643_abnormal_urine_homeostasis3.21584711
11MP0009697_abnormal_copulation3.10631529
12MP0003252_abnormal_bile_duct3.08645943
13MP0002138_abnormal_hepatobiliary_system3.01486164
14MP0001765_abnormal_ion_homeostasis2.74933869
15MP0003806_abnormal_nucleotide_metabolis2.68612028
16MP0005636_abnormal_mineral_homeostasis2.61843768
17MP0001756_abnormal_urination2.55703168
18MP0010329_abnormal_lipoprotein_level2.15014936
19MP0002136_abnormal_kidney_physiology2.11650976
20MP0003878_abnormal_ear_physiology2.02260922
21MP0005377_hearing/vestibular/ear_phenot2.02260922
22MP0001666_abnormal_nutrient_absorption1.95611289
23MP0003191_abnormal_cellular_cholesterol1.88100713
24MP0005451_abnormal_body_composition1.82716141
25MP0005584_abnormal_enzyme/coenzyme_acti1.75489129
26MP0005319_abnormal_enzyme/_coenzyme1.70294715
27MP0003186_abnormal_redox_activity1.61376985
28MP0010368_abnormal_lymphatic_system1.60711671
29MP0002118_abnormal_lipid_homeostasis1.55151161
30MP0009840_abnormal_foam_cell1.47671006
31MP0000538_abnormal_urinary_bladder1.45405652
32MP0005083_abnormal_biliary_tract1.41345622
33MP0000609_abnormal_liver_physiology1.34525997
34MP0001764_abnormal_homeostasis1.33612918
35MP0002876_abnormal_thyroid_physiology1.30677540
36MP0005058_abnormal_lysosome_morphology1.28092293
37MP0001958_emphysema1.28037033
38MP0003300_gastrointestinal_ulcer1.26403461
39MP0002132_abnormal_respiratory_system1.18507214
40MP0008961_abnormal_basal_metabolism1.18106934
41MP0006036_abnormal_mitochondrial_physio1.12215619
42MP0000230_abnormal_systemic_arterial1.10531171
43MP0003283_abnormal_digestive_organ1.02957404
44MP0004264_abnormal_extraembryonic_tissu1.02397559
45MP0001661_extended_life_span0.99906148
46MP0005084_abnormal_gallbladder_morpholo0.99228030
47MP0010234_abnormal_vibrissa_follicle0.92667202
48MP0003868_abnormal_feces_composition0.92203473
49MP0002168_other_aberrant_phenotype0.90354356
50MP0005535_abnormal_body_temperature0.90072853
51MP0009642_abnormal_blood_homeostasis0.89783884
52MP0004885_abnormal_endolymph0.88707446
53MP0005187_abnormal_penis_morphology0.87809236
54MP0003638_abnormal_response/metabolism_0.87246427
55MP0002928_abnormal_bile_duct0.87167967
56MP0001915_intracranial_hemorrhage0.82300974
57MP0002135_abnormal_kidney_morphology0.81902866
58MP0009764_decreased_sensitivity_to0.80638095
59MP0005670_abnormal_white_adipose0.79852948
60MP0003705_abnormal_hypodermis_morpholog0.76946879
61MP0000598_abnormal_liver_morphology0.76883738
62MP0003011_delayed_dark_adaptation0.74176619
63MP0008469_abnormal_protein_level0.72155322
64MP0002282_abnormal_trachea_morphology0.71142311
65MP0005666_abnormal_adipose_tissue0.70675413
66MP0002078_abnormal_glucose_homeostasis0.65704878
67MP0005395_other_phenotype0.65178155
68MP0002896_abnormal_bone_mineralization0.64608088
69MP0000604_amyloidosis0.62094473
70MP0005647_abnormal_sex_gland0.61276082
71MP0008874_decreased_physiological_sensi0.60161149
72MP0002796_impaired_skin_barrier0.59549767
73MP0005220_abnormal_exocrine_pancreas0.59119992
74MP0003953_abnormal_hormone_level0.57013960
75MP0005408_hypopigmentation0.56952768
76MP0002249_abnormal_larynx_morphology0.56587450
77MP0006035_abnormal_mitochondrial_morpho0.56146166
78MP0005376_homeostasis/metabolism_phenot0.55218582
79MP0003329_amyloid_beta_deposits0.54174291
80MP0005464_abnormal_platelet_physiology0.53645358
81MP0005167_abnormal_blood-brain_barrier0.52072221
82MP0002089_abnormal_postnatal_growth/wei0.50794021
83MP0003959_abnormal_lean_body0.50267054
84MP0009785_altered_susceptibility_to0.49436611
85MP0001663_abnormal_digestive_system0.49362287
86MP0004130_abnormal_muscle_cell0.49006304
87MP0004147_increased_porphyrin_level0.45831424
88MP0009765_abnormal_xenobiotic_induced0.44505851
89MP0003879_abnormal_hair_cell0.43406913
90MP0000249_abnormal_blood_vessel0.42890975
91MP0003075_altered_response_to0.42665792
92MP0005023_abnormal_wound_healing0.41781841
93MP0002909_abnormal_adrenal_gland0.41076244
94MP0005266_abnormal_metabolism0.41018174
95MP0002971_abnormal_brown_adipose0.40459623
96MP0003646_muscle_fatigue0.40002051
97MP0005381_digestive/alimentary_phenotyp0.39855699
98MP0009780_abnormal_chondrocyte_physiolo0.38252370
99MP0009763_increased_sensitivity_to0.38130685
100MP0002069_abnormal_eating/drinking_beha0.37147327
101MP0005334_abnormal_fat_pad0.36831035
102MP0002090_abnormal_vision0.34577594
103MP0003724_increased_susceptibility_to0.34409726
104MP0003690_abnormal_glial_cell0.34184930
105MP0009053_abnormal_anal_canal0.33451364
106MP0005166_decreased_susceptibility_to0.33195505
107MP0001845_abnormal_inflammatory_respons0.33116633
108MP0003315_abnormal_perineum_morphology0.32191351
109MP0002332_abnormal_exercise_endurance0.31658947
110MP0002822_catalepsy0.31487035
111MP0000467_abnormal_esophagus_morphology0.30982653
112MP0008872_abnormal_physiological_respon0.30795462
113MP0003656_abnormal_erythrocyte_physiolo0.30119739
114MP0004782_abnormal_surfactant_physiolog0.29614085
115MP0005501_abnormal_skin_physiology0.28836541
116MP0010155_abnormal_intestine_physiology0.27810465
117MP0005448_abnormal_energy_balance0.27762471
118MP0005164_abnormal_response_to0.26787170
119MP0001664_abnormal_digestion0.26684683
120MP0004883_abnormal_blood_vessel0.25856684
121MP0009115_abnormal_fat_cell0.25079342
122MP0010386_abnormal_urinary_bladder0.22209216
123MP0003718_maternal_effect0.19316241
124MP0008873_increased_physiological_sensi0.18838011
125MP0001851_eye_inflammation0.17582200
126MP0009672_abnormal_birth_weight0.17569417
127MP0005197_abnormal_uvea_morphology0.17118720
128MP0002970_abnormal_white_adipose0.17054387
129MP0000566_synostosis0.15775266
130MP0001986_abnormal_taste_sensitivity0.14900737
131MP0004272_abnormal_basement_membrane0.14789710
132MP0002128_abnormal_blood_circulation0.14571172

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of complement system (HP:0005339)8.13550772
2Systemic lupus erythematosus (HP:0002725)6.68218589
3Metabolic alkalosis (HP:0200114)6.65515185
4Increased circulating renin level (HP:0000848)6.28603477
5Gout (HP:0001997)5.97380839
6Hyperactive renin-angiotensin system (HP:0000841)5.91993748
7Conjugated hyperbilirubinemia (HP:0002908)5.88667637
8Hypokalemic alkalosis (HP:0001949)5.77283084
9Hypomagnesemia (HP:0002917)5.51627083
10Hyperglycinuria (HP:0003108)5.35092728
11Glomerulonephritis (HP:0000099)5.22727806
12Abnormality of glutamine family amino acid metabolism (HP:0010902)5.21455867
13Recurrent gram-negative bacterial infections (HP:0005420)5.16425575
14Abnormality of pyrimidine metabolism (HP:0004353)5.09394699
15Abnormality of chloride homeostasis (HP:0011422)5.08545280
16Polyuria (HP:0000103)5.08078201
17Abnormal urine output (HP:0012590)4.94954847
18Alkalosis (HP:0001948)4.73879870
19Proximal tubulopathy (HP:0000114)4.73800547
20Abnormality of magnesium homeostasis (HP:0004921)4.71338757
21Hyperuricemia (HP:0002149)4.64786394
22Increased purine levels (HP:0004368)4.64786394
23Abnormality of serine family amino acid metabolism (HP:0010894)4.58516840
24Abnormality of glycine metabolism (HP:0010895)4.58516840
25Abnormality of the common coagulation pathway (HP:0010990)4.58200823
26Abnormality of renal excretion (HP:0011036)4.57679286
27Abnormality of renin-angiotensin system (HP:0000847)4.55755003
28Hypolipoproteinemia (HP:0010981)4.46014044
29Renal salt wasting (HP:0000127)4.33956808
30Hyperaldosteronism (HP:0000859)4.26616933
31Abnormality of purine metabolism (HP:0004352)4.26067822
32Spontaneous abortion (HP:0005268)4.19862966
33Abnormal drinking behavior (HP:0030082)4.11047902
34Polydipsia (HP:0001959)4.11047902
35Abnormality of aromatic amino acid family metabolism (HP:0004338)4.10683442
36Ketoacidosis (HP:0001993)4.10630131
37Ketosis (HP:0001946)4.05286428
38Abnormality of the intrinsic pathway (HP:0010989)4.01939743
39Tetany (HP:0001281)3.97145608
40Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.83550584
41Nephritis (HP:0000123)3.77815282
42Abnormality of fatty-acid metabolism (HP:0004359)3.74429590
43Abnormality of aspartate family amino acid metabolism (HP:0010899)3.63430760
44Generalized aminoaciduria (HP:0002909)3.61559018
45Hyperglycinemia (HP:0002154)3.61444256
46Hyperammonemia (HP:0001987)3.53944684
47Abnormality of nucleobase metabolism (HP:0010932)3.41500891
48Delayed CNS myelination (HP:0002188)3.36652030
49Hypoalphalipoproteinemia (HP:0003233)3.34727456
50Abnormality of sulfur amino acid metabolism (HP:0004339)3.22729121
51Abnormality of urine glucose concentration (HP:0011016)3.22588455
52Glycosuria (HP:0003076)3.22588455
53Hypokalemia (HP:0002900)3.21826955
54Dicarboxylic aciduria (HP:0003215)3.17030309
55Abnormality of dicarboxylic acid metabolism (HP:0010995)3.17030309
56Hydroxyprolinuria (HP:0003080)3.13121060
57Abnormality of proline metabolism (HP:0010907)3.13121060
58Renal tubular acidosis (HP:0001947)3.12581322
59Xanthomatosis (HP:0000991)3.11399960
60Abnormality of monocarboxylic acid metabolism (HP:0010996)3.01852177
61Intrahepatic cholestasis (HP:0001406)2.97846242
62Hypercalciuria (HP:0002150)2.95630691
63Vascular calcification (HP:0004934)2.92848036
64Reduced antithrombin III activity (HP:0001976)2.89719572
65Gingival bleeding (HP:0000225)2.87426479
66Metabolic acidosis (HP:0001942)2.86427118
67Osteomalacia (HP:0002749)2.76162274
68Hypoglycemic coma (HP:0001325)2.72042763
69Hyperphosphaturia (HP:0003109)2.71119903
70Abnormality of potassium homeostasis (HP:0011042)2.69813364
71Deep venous thrombosis (HP:0002625)2.69546264
72Hypercholesterolemia (HP:0003124)2.69215028
73Malnutrition (HP:0004395)2.67409043
74Vomiting (HP:0002013)2.63803414
75Cardiovascular calcification (HP:0011915)2.60580544
76Neonatal hypoglycemia (HP:0001998)2.59178273
77Nephrolithiasis (HP:0000787)2.57902113
78Epidermoid cyst (HP:0200040)2.56956542
79Thrombophlebitis (HP:0004418)2.55595190
80Lethargy (HP:0001254)2.53765303
81Decreased circulating renin level (HP:0003351)2.51410657
82Purpura (HP:0000979)2.48941995
83Abnormal urine phosphate concentration (HP:0012599)2.47180942
84Rickets (HP:0002748)2.45334460
85Pulmonary embolism (HP:0002204)2.44986197
86Abnormal tarsal ossification (HP:0008369)2.37593525
87Mitral stenosis (HP:0001718)2.35650704
88Hypophosphatemia (HP:0002148)2.35552218
89Nephrocalcinosis (HP:0000121)2.32400551
90Steatorrhea (HP:0002570)2.31356136
91Hemorrhage of the eye (HP:0011885)2.30145605
92Enlarged kidneys (HP:0000105)2.29590610
93Dehydration (HP:0001944)2.28245291
94Menorrhagia (HP:0000132)2.27634046
95Neonatal onset (HP:0003623)2.27021104
96Fair hair (HP:0002286)2.26084740
97Abnormal gallbladder physiology (HP:0012438)2.18809241
98Cholecystitis (HP:0001082)2.18809241
99Irritability (HP:0000737)2.15920561
100Confusion (HP:0001289)2.15605228
101Methylmalonic aciduria (HP:0012120)2.14842983
102Abnormality of serum amino acid levels (HP:0003112)2.14072284
103Widely patent fontanelles and sutures (HP:0004492)2.13974682
104Abnormality of sodium homeostasis (HP:0010931)2.10203767
105Delayed epiphyseal ossification (HP:0002663)2.09279994
106Vacuolated lymphocytes (HP:0001922)2.08122012
107Cholelithiasis (HP:0001081)2.07923821
108Joint hemorrhage (HP:0005261)2.07512191
109Nausea (HP:0002018)2.07033943
110Hypobetalipoproteinemia (HP:0003563)2.06317640
111Hyponatremia (HP:0002902)2.05185721
112Elevated alkaline phosphatase (HP:0003155)2.03107110
113Arthropathy (HP:0003040)2.03002674
114Abnormal enzyme/coenzyme activity (HP:0012379)2.01866869
115Complement deficiency (HP:0004431)10.1108922
116Gangrene (HP:0100758)1.97313114
117Abnormal gallbladder morphology (HP:0012437)1.96438648
118Renal tubular dysfunction (HP:0000124)1.94836945
119Cerebral edema (HP:0002181)1.94513720
120Hepatocellular carcinoma (HP:0001402)1.93919398
121Abnormality of iron homeostasis (HP:0011031)1.93675895
122Adrenal overactivity (HP:0002717)1.91901371
123Abnormality of the Achilles tendon (HP:0005109)1.90919378
124Hyperlipoproteinemia (HP:0010980)1.90652596
125Potter facies (HP:0002009)1.90169494
126Facial shape deformation (HP:0011334)1.90169494
127Increased serum ferritin (HP:0003281)1.89934274
128Abnormality of alkaline phosphatase activity (HP:0004379)1.89482213
129Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.88900758
130Fat malabsorption (HP:0002630)1.83941853
131Late onset (HP:0003584)1.83740287
132Chondrocalcinosis (HP:0000934)1.83338806
133Prolonged partial thromboplastin time (HP:0003645)1.80489882
134Sensorimotor neuropathy (HP:0007141)1.80439726
135Abnormality of vitamin metabolism (HP:0100508)1.77994459
136Spastic diplegia (HP:0001264)1.75928171
137Atrioventricular block (HP:0001678)1.74723368
138Abnormality of methionine metabolism (HP:0010901)1.74605728
139Abnormality of transition element cation homeostasis (HP:0011030)1.73947804
140Hyperbilirubinemia (HP:0002904)1.73941943
141Myocardial infarction (HP:0001658)1.73583161
142Abnormality of carpal bone ossification (HP:0006257)1.72605737
143Poikilocytosis (HP:0004447)1.70725540
144Joint swelling (HP:0001386)1.69106546
145Impaired platelet aggregation (HP:0003540)1.68246345
146Abnormal platelet function (HP:0011869)1.68246345
147Hypophosphatemic rickets (HP:0004912)1.64838316
148Increased mean platelet volume (HP:0011877)1.63372804
149Cerebral palsy (HP:0100021)1.63352055
150Pancreatitis (HP:0001733)1.62572922
151Epistaxis (HP:0000421)1.60627854
152Abnormal biliary tract physiology (HP:0012439)1.56182129
153Bile duct proliferation (HP:0001408)1.56182129

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK38.25382018
2WNK46.99157057
3OXSR16.50173639
4BCKDK4.40610906
5STK393.03910449
6PRPF4B2.44664950
7STK38L2.40682910
8MST1R2.20768591
9FGFR41.87539513
10MAP3K71.79589158
11ERN11.73653890
12PDK31.71739077
13PDK41.71739077
14NEK11.68835292
15SGK4941.67530981
16SGK2231.67530981
17EPHA31.65917578
18PRKCG1.53967319
19TNK21.36883162
20SIK11.36103928
21NTRK31.35647006
22PDK21.34058795
23IGF1R1.24281883
24WNK11.23411658
25FRK1.19862646
26JAK11.13505057
27FGFR31.05891440
28PTK61.05652214
29PINK11.04441749
30STK381.04414751
31TRIB31.02948779
32MST41.02081294
33INSRR0.97562640
34NLK0.97492125
35ARAF0.96582747
36SGK30.95140148
37GRK60.94821043
38PRKG10.92402995
39SGK20.91660315
40MAP3K60.89120268
41TAOK20.86918352
42TIE10.85834566
43LRRK20.85387256
44PRKAA20.85005607
45EPHB10.81727871
46DYRK1B0.79844767
47PKN20.79468553
48MAP3K120.79272782
49ABL20.79009142
50GSK3A0.77556741
51PRKAA10.77277477
52MAPK70.76401142
53MAP3K10.74596918
54CSF1R0.74264042
55PIK3CG0.69060881
56MAPK110.67345503
57MET0.65950129
58CDK60.65780853
59MAP2K20.65724072
60RET0.64811428
61TGFBR20.64638032
62PTK20.62634351
63SCYL20.61772469
64PDPK10.61754431
65CSNK1D0.60652071
66PRKCB0.60506648
67MYLK0.60472333
68CAMKK10.59331963
69ZAP700.58529096
70BLK0.57427680
71RIPK10.56637856
72RPS6KA30.56068385
73STK160.55998998
74LATS10.51510047
75TESK20.50685707
76MAP3K30.50645805
77CSNK1A10.50420719
78JAK20.49518457
79SRC0.49367654
80PRKACB0.48774720
81EPHB20.47130352
82TYK20.47083737
83CDK40.46948952
84KDR0.46068671
85PRKACG0.45198595
86CAMK1D0.44651871
87PRKCZ0.44610140
88SGK10.44230944
89PAK40.43742543
90CAMK2G0.43074558
91PDK10.42730034
92DAPK20.41191258
93MAP3K20.40576114
94TAOK30.39906647
95FER0.39451618
96MAP2K40.38663552
97STK110.36771769
98MAP3K140.36687044
99CSNK1E0.36404256
100CSNK2A20.36169909
101PAK30.34778261
102CAMK1G0.34133083
103MAPKAPK30.33621216
104CSK0.33131503
105CSNK2A10.32634463
106PIM20.31609410
107IKBKE0.31559009
108MAPK30.30517162
109PRKCI0.28931911
110MAP2K10.27947424
111MTOR0.26993609
112ERBB40.25653223
113MAP2K30.25482404
114PRKCA0.24868788
115MAPK120.23335672
116KSR20.22493879
117PTK2B0.21380778
118PRKD20.21290697
119MAPK150.21061636
120PIK3CA0.20807002
121PRKCQ0.20788210
122PRKCD0.20574569
123ERBB20.19905891
124MAP3K110.19677045
125EPHA40.19350221
126TBK10.18639684
127TAOK10.17114802
128MAP2K60.16882074
129PRKACA0.15826551
130MAPK40.15807366
131STK100.15751702
132PRKG20.15121515
133AKT20.14669713
134LMTK20.13377442
135FLT30.12440801
136NEK90.11941791
137ICK0.11478997
138CAMKK20.10975311
139MAP3K130.10637611
140NTRK10.10272948
141PRKCH0.09443017

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.71299062
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.33193922
3Butanoate metabolism_Homo sapiens_hsa006503.21525498
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.08739806
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.87681358
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.77964812
7Propanoate metabolism_Homo sapiens_hsa006402.77788868
8* Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.73707840
9Fatty acid degradation_Homo sapiens_hsa000712.60129025
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.56319774
11Tryptophan metabolism_Homo sapiens_hsa003802.54625698
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.47282012
13Nitrogen metabolism_Homo sapiens_hsa009102.41420013
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.34228098
15Primary bile acid biosynthesis_Homo sapiens_hsa001202.28776504
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.28058866
17Sulfur metabolism_Homo sapiens_hsa009202.25844363
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.18317460
19* Peroxisome_Homo sapiens_hsa041462.13885951
20Arginine biosynthesis_Homo sapiens_hsa002202.07642036
21Pyruvate metabolism_Homo sapiens_hsa006201.97412247
22Fatty acid metabolism_Homo sapiens_hsa012121.96325543
23Bile secretion_Homo sapiens_hsa049761.87926451
24beta-Alanine metabolism_Homo sapiens_hsa004101.85531874
25Vitamin digestion and absorption_Homo sapiens_hsa049771.77055957
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.76683825
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.76216535
28PPAR signaling pathway_Homo sapiens_hsa033201.69135465
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.68793356
30Chemical carcinogenesis_Homo sapiens_hsa052041.51546316
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.48300005
32* Carbon metabolism_Homo sapiens_hsa012001.46333503
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.45506985
34Histidine metabolism_Homo sapiens_hsa003401.41693162
35Prion diseases_Homo sapiens_hsa050201.31389340
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30699782
37Selenocompound metabolism_Homo sapiens_hsa004501.27473926
38Glutathione metabolism_Homo sapiens_hsa004801.25511983
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.25192604
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.23090143
41Starch and sucrose metabolism_Homo sapiens_hsa005001.22274691
42Biosynthesis of amino acids_Homo sapiens_hsa012301.17732321
43Arginine and proline metabolism_Homo sapiens_hsa003301.16121252
44Fatty acid elongation_Homo sapiens_hsa000621.14550017
45Retinol metabolism_Homo sapiens_hsa008301.12442758
46Lysine degradation_Homo sapiens_hsa003101.11648607
47Phenylalanine metabolism_Homo sapiens_hsa003601.09476032
48Complement and coagulation cascades_Homo sapiens_hsa046100.99434048
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.98235196
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97473901
51Folate biosynthesis_Homo sapiens_hsa007900.94626715
52Tyrosine metabolism_Homo sapiens_hsa003500.90908278
53Glycerolipid metabolism_Homo sapiens_hsa005610.84118867
54Collecting duct acid secretion_Homo sapiens_hsa049660.76768491
55Fructose and mannose metabolism_Homo sapiens_hsa000510.76074236
56Mineral absorption_Homo sapiens_hsa049780.70360903
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.70203884
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68594162
59Pentose phosphate pathway_Homo sapiens_hsa000300.68033972
60Sulfur relay system_Homo sapiens_hsa041220.67964825
61Fat digestion and absorption_Homo sapiens_hsa049750.67242845
62ABC transporters_Homo sapiens_hsa020100.65648774
63Steroid biosynthesis_Homo sapiens_hsa001000.63861192
64Protein digestion and absorption_Homo sapiens_hsa049740.60688543
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59914671
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55210601
67* Metabolic pathways_Homo sapiens_hsa011000.54853518
68Staphylococcus aureus infection_Homo sapiens_hsa051500.52221805
69Oxidative phosphorylation_Homo sapiens_hsa001900.52095569
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50207693
71Other glycan degradation_Homo sapiens_hsa005110.49278914
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45294402
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43193265
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40669919
75Caffeine metabolism_Homo sapiens_hsa002320.38782147
76Pertussis_Homo sapiens_hsa051330.35346040
77Renin-angiotensin system_Homo sapiens_hsa046140.34218724
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32121964
79Parkinsons disease_Homo sapiens_hsa050120.29226011
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28903136
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22240147
82Thyroid hormone synthesis_Homo sapiens_hsa049180.22201501
83Arachidonic acid metabolism_Homo sapiens_hsa005900.21851881
84Galactose metabolism_Homo sapiens_hsa000520.20531868
85Lysosome_Homo sapiens_hsa041420.19337619
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.18917167
87One carbon pool by folate_Homo sapiens_hsa006700.18426002
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.16998572
89Insulin resistance_Homo sapiens_hsa049310.16889855
90Systemic lupus erythematosus_Homo sapiens_hsa053220.14386476
91Alzheimers disease_Homo sapiens_hsa050100.10782191
92Linoleic acid metabolism_Homo sapiens_hsa005910.09285881
93Ovarian steroidogenesis_Homo sapiens_hsa049130.02194676
94AMPK signaling pathway_Homo sapiens_hsa041520.01804244
95Glucagon signaling pathway_Homo sapiens_hsa049220.01330229
96Fatty acid biosynthesis_Homo sapiens_hsa000610.00187493
97Cocaine addiction_Homo sapiens_hsa05030-0.2755961
98Type II diabetes mellitus_Homo sapiens_hsa04930-0.2667159
99Circadian rhythm_Homo sapiens_hsa04710-0.2487800
100N-Glycan biosynthesis_Homo sapiens_hsa00510-0.2428291
101Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2387301
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.2257082
103Sphingolipid metabolism_Homo sapiens_hsa00600-0.2113381
104Insulin signaling pathway_Homo sapiens_hsa04910-0.1650705
105African trypanosomiasis_Homo sapiens_hsa05143-0.1180352
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.0829992
107Huntingtons disease_Homo sapiens_hsa05016-0.0702191
108Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0544260
109Vitamin B6 metabolism_Homo sapiens_hsa00750-0.0469043
110Cardiac muscle contraction_Homo sapiens_hsa04260-0.0440959
111Gastric acid secretion_Homo sapiens_hsa04971-0.0329277
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0240745
113Serotonergic synapse_Homo sapiens_hsa04726-0.0052082
114Amoebiasis_Homo sapiens_hsa05146-0.0011847

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