HAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.51290258
2synaptic vesicle maturation (GO:0016188)6.42396716
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)6.21747353
4locomotory exploration behavior (GO:0035641)5.55302547
5behavioral response to nicotine (GO:0035095)5.42982449
6regulation of synaptic vesicle exocytosis (GO:2000300)5.21942484
7vocalization behavior (GO:0071625)4.96636225
8synaptic vesicle exocytosis (GO:0016079)4.88325305
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.80834130
10neurotransmitter secretion (GO:0007269)4.73952762
11multicellular organism reproduction (GO:0032504)4.73161805
12regulation of synaptic vesicle transport (GO:1902803)4.59788057
13regulation of acrosome reaction (GO:0060046)4.58388541
14glutamate secretion (GO:0014047)4.50599348
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.49141616
16regulation of glutamate receptor signaling pathway (GO:1900449)4.45776670
17layer formation in cerebral cortex (GO:0021819)4.42051977
18neuron cell-cell adhesion (GO:0007158)4.41834813
19gamma-aminobutyric acid transport (GO:0015812)4.37674911
20neuromuscular process controlling posture (GO:0050884)4.37218682
21exploration behavior (GO:0035640)4.24178701
22activation of protein kinase A activity (GO:0034199)4.21221621
23ionotropic glutamate receptor signaling pathway (GO:0035235)4.17637891
24piRNA metabolic process (GO:0034587)4.15264619
25protein localization to synapse (GO:0035418)4.15158671
26proline transport (GO:0015824)4.14775771
27regulation of neuronal synaptic plasticity (GO:0048168)4.13410815
28cellular potassium ion homeostasis (GO:0030007)4.05863419
29dendritic spine morphogenesis (GO:0060997)4.05766209
30synaptic vesicle docking involved in exocytosis (GO:0016081)4.03373108
31fucose catabolic process (GO:0019317)4.00465766
32L-fucose metabolic process (GO:0042354)4.00465766
33L-fucose catabolic process (GO:0042355)4.00465766
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.95107908
35neurotransmitter transport (GO:0006836)3.94908941
36sodium ion export (GO:0071436)3.93696529
37cerebellar Purkinje cell layer development (GO:0021680)3.93010356
38DNA deamination (GO:0045006)3.89150799
39DNA methylation involved in gamete generation (GO:0043046)3.84514134
40glycine transport (GO:0015816)3.77422380
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.76618228
42cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.74896686
43regulation of synapse structural plasticity (GO:0051823)3.65032867
44neuron recognition (GO:0008038)3.57276702
45cell communication by electrical coupling (GO:0010644)3.57188782
46synaptic transmission, glutamatergic (GO:0035249)3.56221560
47regulation of neurotransmitter levels (GO:0001505)3.56118396
48retinal cone cell development (GO:0046549)3.55208631
49neuronal action potential propagation (GO:0019227)3.52314481
50long-term memory (GO:0007616)3.51812570
51transmission of nerve impulse (GO:0019226)3.51266986
52detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.50499634
53neuronal ion channel clustering (GO:0045161)3.49578143
54glutamate receptor signaling pathway (GO:0007215)3.49080191
55neuromuscular process controlling balance (GO:0050885)3.47639819
56cerebellar Purkinje cell differentiation (GO:0021702)3.44648858
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.43407656
58protein polyglutamylation (GO:0018095)3.43095145
59positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.41836347
60regulation of vesicle fusion (GO:0031338)3.41626283
61positive regulation of membrane potential (GO:0045838)3.35134422
62regulation of calcium ion-dependent exocytosis (GO:0017158)3.34626856
63regulation of female gonad development (GO:2000194)3.34333243
64response to pheromone (GO:0019236)3.33983986
65potassium ion homeostasis (GO:0055075)3.32913098
66mating behavior (GO:0007617)3.31836477
67epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.31757101
68membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.31343439
69synaptic vesicle endocytosis (GO:0048488)3.31019912
70negative regulation of synaptic transmission, GABAergic (GO:0032229)3.30586490
71neuron-neuron synaptic transmission (GO:0007270)3.29614580
72prepulse inhibition (GO:0060134)3.25403049
73axonal fasciculation (GO:0007413)3.24906442
74response to auditory stimulus (GO:0010996)3.23369331
75kidney morphogenesis (GO:0060993)3.23189613
76negative regulation of telomere maintenance (GO:0032205)3.17770812
77presynaptic membrane assembly (GO:0097105)3.16867146
78neurotransmitter-gated ion channel clustering (GO:0072578)3.15250814
79regulation of neurotransmitter secretion (GO:0046928)3.14641518
80regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.13255688
81gamma-aminobutyric acid signaling pathway (GO:0007214)3.12329552
82auditory behavior (GO:0031223)3.11658806
83dendrite morphogenesis (GO:0048813)3.11453060
84positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.11420447
85potassium ion import (GO:0010107)3.10696608
86social behavior (GO:0035176)3.10619051
87intraspecies interaction between organisms (GO:0051703)3.10619051
88postsynaptic membrane organization (GO:0001941)3.08886911
89* positive regulation of synaptic transmission, GABAergic (GO:0032230)3.08022138
90membrane depolarization during action potential (GO:0086010)3.07572283
91regulation of excitatory postsynaptic membrane potential (GO:0060079)3.05432783
92nonmotile primary cilium assembly (GO:0035058)3.03403722
93regulation of ARF protein signal transduction (GO:0032012)3.01041801
94regulation of postsynaptic membrane potential (GO:0060078)3.00684738
95regulation of female receptivity (GO:0045924)3.00467937
96chemosensory behavior (GO:0007635)3.00287052
97detection of light stimulus involved in sensory perception (GO:0050962)2.99385710
98detection of light stimulus involved in visual perception (GO:0050908)2.99385710
99innervation (GO:0060384)2.98370653
100regulation of synaptic plasticity (GO:0048167)2.97943349
101positive regulation of potassium ion transmembrane transport (GO:1901381)2.97397279
102membrane hyperpolarization (GO:0060081)2.96412082
103positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.95644966
104kynurenine metabolic process (GO:0070189)2.94889823
105signal release (GO:0023061)2.94714034
106preassembly of GPI anchor in ER membrane (GO:0016254)2.94534555
107pyrimidine nucleobase catabolic process (GO:0006208)2.94262768
108regulation of cilium movement (GO:0003352)2.91766725
109epithelial cilium movement (GO:0003351)2.91244495
110regulation of neurotransmitter transport (GO:0051588)2.90805985
111cellular ketone body metabolic process (GO:0046950)2.90071287
112tryptophan catabolic process (GO:0006569)2.89475388
113indole-containing compound catabolic process (GO:0042436)2.89475388
114indolalkylamine catabolic process (GO:0046218)2.89475388
115indolalkylamine metabolic process (GO:0006586)2.89416000
116reproduction (GO:0000003)2.89044660
117neuromuscular process (GO:0050905)2.87147562
118regulation of glutamate secretion (GO:0014048)2.87038488
119suckling behavior (GO:0001967)2.86566386
120axoneme assembly (GO:0035082)2.85807796
121synapse assembly (GO:0007416)2.85581073
122regulation of synaptic transmission, glutamatergic (GO:0051966)2.85272822
123regulation of cAMP-dependent protein kinase activity (GO:2000479)2.84308700
124primary amino compound metabolic process (GO:1901160)2.82776737
125calcium ion-dependent exocytosis (GO:0017156)2.82100536
126dopamine receptor signaling pathway (GO:0007212)2.81629950
127neuronal action potential (GO:0019228)2.81629761
128female mating behavior (GO:0060180)2.80471833
129synapse organization (GO:0050808)2.79428568
130presynaptic membrane organization (GO:0097090)2.79275008
131long-term synaptic potentiation (GO:0060291)2.78874690
132regulation of action potential (GO:0098900)2.78464390
133water-soluble vitamin biosynthetic process (GO:0042364)2.77558042
134serotonin metabolic process (GO:0042428)2.76382149
135positive regulation of exocytosis (GO:0045921)2.75735715
136synaptic transmission, cholinergic (GO:0007271)2.74752027
137membrane repolarization (GO:0086009)2.74702763
138negative regulation of cytosolic calcium ion concentration (GO:0051481)2.74334425
139dendritic spine organization (GO:0097061)2.74234773
140cellular response to glucagon stimulus (GO:0071377)2.73523412
141behavioral response to ethanol (GO:0048149)2.72929583
142regulation of neurotransmitter uptake (GO:0051580)2.72633122
143platelet dense granule organization (GO:0060155)2.69018818
144regulation of mesoderm development (GO:2000380)2.68128005
145reflex (GO:0060004)2.67085631
146positive regulation of oligodendrocyte differentiation (GO:0048714)2.60525926
147positive regulation of meiosis (GO:0045836)2.59790637
148nucleobase catabolic process (GO:0046113)2.59041637
149regulation of hippo signaling (GO:0035330)2.57174153
150indole-containing compound metabolic process (GO:0042430)2.56918042
151positive regulation of sodium ion transmembrane transport (GO:1902307)2.56453988
152negative regulation of mast cell activation (GO:0033004)2.55680000
153cilium morphogenesis (GO:0060271)2.55632095
154regulation of meiosis I (GO:0060631)2.55352438
155ketone body metabolic process (GO:1902224)2.54198002
156NADH dehydrogenase complex assembly (GO:0010257)2.54033417
157mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.54033417
158mitochondrial respiratory chain complex I assembly (GO:0032981)2.54033417
159axon ensheathment in central nervous system (GO:0032291)2.52126770
160central nervous system myelination (GO:0022010)2.52126770
161peristalsis (GO:0030432)2.50333934
162protein localization to cilium (GO:0061512)2.49971530
163protein complex biogenesis (GO:0070271)2.48752558
164positive regulation of meiotic cell cycle (GO:0051446)2.48623106
165G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.48359650
166auditory receptor cell stereocilium organization (GO:0060088)2.47326298
167cornea development in camera-type eye (GO:0061303)2.45449888
168protein-cofactor linkage (GO:0018065)2.45011403
169cAMP catabolic process (GO:0006198)2.44011897
170pseudouridine synthesis (GO:0001522)2.43722755
171male meiosis I (GO:0007141)2.43453613
172tryptophan metabolic process (GO:0006568)2.42592972
173photoreceptor cell development (GO:0042461)2.42548146
174cilium movement (GO:0003341)2.42234406
175regulation of telomere maintenance (GO:0032204)2.41714697
176regulation of rhodopsin mediated signaling pathway (GO:0022400)2.41537552
177photoreceptor cell maintenance (GO:0045494)2.41490237
178DNA double-strand break processing (GO:0000729)2.41026343
179rhodopsin mediated signaling pathway (GO:0016056)2.39856248
180meiotic cell cycle (GO:0051321)2.39800631
181sulfation (GO:0051923)2.39565044
182startle response (GO:0001964)2.39233282
183cilium organization (GO:0044782)2.39004637
184neuromuscular synaptic transmission (GO:0007274)2.38005963
185L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.36920332

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.11390979
2REST_21632747_ChIP-Seq_MESCs_Mouse3.12412890
3CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.07015219
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.85359406
5VDR_22108803_ChIP-Seq_LS180_Human2.84540872
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82452480
7GBX2_23144817_ChIP-Seq_PC3_Human2.74065953
8* RARB_27405468_Chip-Seq_BRAIN_Mouse2.73155380
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.70278272
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.69106598
11DROSHA_22980978_ChIP-Seq_HELA_Human2.66221049
12* REST_18959480_ChIP-ChIP_MESCs_Mouse2.59126566
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.57413476
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48874960
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42931995
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41696997
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41696997
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.41277208
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.40568390
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.37778739
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31399794
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29481595
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28355492
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27561878
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27413982
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.24889080
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.21360511
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07684625
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.06308486
30EED_16625203_ChIP-ChIP_MESCs_Mouse2.04462295
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03635587
32RNF2_27304074_Chip-Seq_ESCs_Mouse2.03604876
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90115708
34ZNF274_21170338_ChIP-Seq_K562_Hela1.81340565
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.80778215
36EWS_26573619_Chip-Seq_HEK293_Human1.77644564
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76831911
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76499243
39FUS_26573619_Chip-Seq_HEK293_Human1.74951269
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.71059156
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.66740625
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66228306
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63768465
44RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.62387010
45ER_23166858_ChIP-Seq_MCF-7_Human1.59231641
46TP53_22573176_ChIP-Seq_HFKS_Human1.56029503
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55654215
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55654215
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.54467431
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.54366033
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51821866
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.50523463
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50226805
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50033335
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49640991
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49251646
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48644790
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48189372
59AR_21572438_ChIP-Seq_LNCaP_Human1.47305546
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45554287
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44921046
62SMAD4_21799915_ChIP-Seq_A2780_Human1.44806738
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44329090
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43589603
65IRF1_19129219_ChIP-ChIP_H3396_Human1.40589849
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39685432
67CBP_20019798_ChIP-Seq_JUKART_Human1.39685432
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.38361106
69BCAT_22108803_ChIP-Seq_LS180_Human1.34923751
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34153985
71EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33090029
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32149526
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.29503058
74KDM2B_26808549_Chip-Seq_K562_Human1.29171516
75NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26767598
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26707670
77FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26487414
78FOXA1_25329375_ChIP-Seq_VCAP_Human1.26487414
79TCF4_22108803_ChIP-Seq_LS180_Human1.26209123
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26194074
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25925078
82SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25863689
83AR_19668381_ChIP-Seq_PC3_Human1.25556403
84SMAD4_21741376_ChIP-Seq_EPCs_Human1.25188926
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24561200
86MYC_18940864_ChIP-ChIP_HL60_Human1.23427472
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23426359
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22631697
89IGF1R_20145208_ChIP-Seq_DFB_Human1.21857399
90* GATA3_21878914_ChIP-Seq_MCF-7_Human1.20846664
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19786455
92HOXB7_26014856_ChIP-Seq_BT474_Human1.17150548
93STAT3_23295773_ChIP-Seq_U87_Human1.16065244
94NANOG_19829295_ChIP-Seq_ESCs_Human1.15638150
95SOX2_19829295_ChIP-Seq_ESCs_Human1.15638150
96PRDM14_20953172_ChIP-Seq_ESCs_Human1.15460856
97NCOR_22424771_ChIP-Seq_293T_Human1.14549761
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13516612
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11955943
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11698219
101RING1B_27294783_Chip-Seq_NPCs_Mouse1.09458384
102ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09277337
103TAF15_26573619_Chip-Seq_HEK293_Human1.08583883
104PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08340347
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07926889
106WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07854488
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06197903
108YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05280523
109OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04950632
110CTCF_27219007_Chip-Seq_Bcells_Human1.04857111
111SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04688799
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.04522514
113* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03630381
114BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03628300
115GABP_17652178_ChIP-ChIP_JURKAT_Human1.03490520
116FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03228728
117SMAD3_21741376_ChIP-Seq_ESCs_Human1.02578203
118EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02168584
119FLI1_21867929_ChIP-Seq_TH2_Mouse1.01523071
120AR_25329375_ChIP-Seq_VCAP_Human1.00862293
121EST1_17652178_ChIP-ChIP_JURKAT_Human1.00672163
122MYC_19829295_ChIP-Seq_ESCs_Human1.00102639
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99711551
124RNF2_27304074_Chip-Seq_NSC_Mouse0.99004651
125NFE2_27457419_Chip-Seq_LIVER_Mouse0.98843019
126TET1_21490601_ChIP-Seq_MESCs_Mouse0.98443584
127DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97510997
128RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97285262
129PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96808579
130CBX2_27304074_Chip-Seq_ESCs_Mouse0.96112936
131SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95318099
132CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95273637
133TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94989563
134PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94725238
135TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94572130
136P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93380930
137* TCF4_23295773_ChIP-Seq_U87_Human0.92890002
138ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91583025
139P300_19829295_ChIP-Seq_ESCs_Human0.91344702
140TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.91049258
141ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90726713
142SMAD4_21741376_ChIP-Seq_HESCs_Human0.90562584
143ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88662191
144OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86278210
145PIAS1_25552417_ChIP-Seq_VCAP_Human0.85308969
146AHR_22903824_ChIP-Seq_MCF-7_Human0.84492879
147KLF4_19829295_ChIP-Seq_ESCs_Human0.84485590
148SMC4_20622854_ChIP-Seq_HELA_Human0.84233855
149CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83725072
150RUNX2_22187159_ChIP-Seq_PCA_Human0.83597481
151ARNT_22903824_ChIP-Seq_MCF-7_Human0.83185574
152NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82789864
153* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81669604
154SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80909859
155SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.80895063

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.29979293
2MP0003880_abnormal_central_pattern4.29204073
3MP0003635_abnormal_synaptic_transmissio3.74977342
4MP0005423_abnormal_somatic_nervous3.17663494
5MP0004270_analgesia3.14819421
6MP0003122_maternal_imprinting3.07672503
7MP0009745_abnormal_behavioral_response3.04564192
8MP0002064_seizures2.89273505
9MP0002063_abnormal_learning/memory/cond2.86848349
10MP0005645_abnormal_hypothalamus_physiol2.84719175
11MP0009046_muscle_twitch2.76722812
12MP0002909_abnormal_adrenal_gland2.73562286
13MP0003283_abnormal_digestive_organ2.69513963
14MP0002102_abnormal_ear_morphology2.54191674
15MP0002572_abnormal_emotion/affect_behav2.49440397
16MP0001968_abnormal_touch/_nociception2.44938674
17MP0002734_abnormal_mechanical_nocicepti2.37683168
18MP0002272_abnormal_nervous_system2.31775859
19MP0009780_abnormal_chondrocyte_physiolo2.28862078
20MP0003718_maternal_effect2.25027087
21MP0003787_abnormal_imprinting2.23555665
22MP0001501_abnormal_sleep_pattern2.16537540
23MP0003195_calcinosis2.15592876
24MP0001486_abnormal_startle_reflex2.14963572
25MP0002822_catalepsy2.09501818
26MP0005646_abnormal_pituitary_gland2.04865785
27MP0002733_abnormal_thermal_nociception1.99616445
28MP0000013_abnormal_adipose_tissue1.94725137
29MP0006276_abnormal_autonomic_nervous1.93876240
30MP0004147_increased_porphyrin_level1.90195403
31MP0001440_abnormal_grooming_behavior1.85153878
32MP0001970_abnormal_pain_threshold1.84203224
33MP0006292_abnormal_olfactory_placode1.82729488
34MP0001485_abnormal_pinna_reflex1.81137712
35MP0003136_yellow_coat_color1.77770637
36MP0004858_abnormal_nervous_system1.73193663
37MP0002557_abnormal_social/conspecific_i1.71001077
38MP0002067_abnormal_sensory_capabilities1.69779285
39MP0002184_abnormal_innervation1.66482951
40MP0004811_abnormal_neuron_physiology1.64075327
41MP0008961_abnormal_basal_metabolism1.62671690
42MP0003329_amyloid_beta_deposits1.61491331
43MP0004885_abnormal_endolymph1.61220683
44MP0000427_abnormal_hair_cycle1.60953293
45MP0000955_abnormal_spinal_cord1.60484923
46MP0001502_abnormal_circadian_rhythm1.59239100
47MP0003123_paternal_imprinting1.58194610
48MP0002736_abnormal_nociception_after1.55992841
49MP0001986_abnormal_taste_sensitivity1.55490255
50MP0004924_abnormal_behavior1.53802739
51MP0005386_behavior/neurological_phenoty1.53802739
52MP0001984_abnormal_olfaction1.49028134
53MP0004742_abnormal_vestibular_system1.48861256
54MP0004133_heterotaxia1.48361409
55MP0008569_lethality_at_weaning1.47890727
56MP0003646_muscle_fatigue1.47544812
57MP0000778_abnormal_nervous_system1.47174749
58MP0002876_abnormal_thyroid_physiology1.45954085
59MP0003121_genomic_imprinting1.40402631
60MP0006072_abnormal_retinal_apoptosis1.40121070
61MP0008789_abnormal_olfactory_epithelium1.39618954
62MP0002735_abnormal_chemical_nociception1.36838112
63MP0008875_abnormal_xenobiotic_pharmacok1.34747734
64MP0002882_abnormal_neuron_morphology1.33857176
65* MP0002066_abnormal_motor_capabilities/c1.31545488
66MP0010386_abnormal_urinary_bladder1.31126907
67MP0000383_abnormal_hair_follicle1.30740916
68MP0003879_abnormal_hair_cell1.29200995
69MP0004142_abnormal_muscle_tone1.27465694
70MP0003119_abnormal_digestive_system1.25203451
71MP0003633_abnormal_nervous_system1.22841546
72MP0004043_abnormal_pH_regulation1.18848850
73MP0001529_abnormal_vocalization1.18516145
74MP0002638_abnormal_pupillary_reflex1.18468080
75MP0005379_endocrine/exocrine_gland_phen1.18253682
76MP0005389_reproductive_system_phenotype1.16230011
77MP0000631_abnormal_neuroendocrine_gland1.16074764
78MP0003878_abnormal_ear_physiology1.14561342
79MP0005377_hearing/vestibular/ear_phenot1.14561342
80MP0001919_abnormal_reproductive_system1.11669498
81MP0001929_abnormal_gametogenesis1.06396747
82* MP0002152_abnormal_brain_morphology1.04568616
83MP0003890_abnormal_embryonic-extraembry1.03321834
84MP0004145_abnormal_muscle_electrophysio1.02223493
85MP0005195_abnormal_posterior_eye1.01490790
86MP0001963_abnormal_hearing_physiology1.00679486
87MP0003634_abnormal_glial_cell1.00456449
88* MP0002069_abnormal_eating/drinking_beha1.00175083
89MP0002938_white_spotting1.00164030
90MP0002751_abnormal_autonomic_nervous0.99798921
91* MP0002229_neurodegeneration0.99560756
92MP0003011_delayed_dark_adaptation0.99337233
93MP0005551_abnormal_eye_electrophysiolog0.98439885
94MP0003172_abnormal_lysosome_physiology0.98247915
95MP0000026_abnormal_inner_ear0.97546866
96MP0003690_abnormal_glial_cell0.96403099
97MP0002210_abnormal_sex_determination0.94994994
98MP0005174_abnormal_tail_pigmentation0.94006715
99MP0000751_myopathy0.93872874
100MP0003631_nervous_system_phenotype0.93613529
101MP0002160_abnormal_reproductive_system0.92337760
102MP0005535_abnormal_body_temperature0.90719372
103MP0010234_abnormal_vibrissa_follicle0.90671652
104MP0001905_abnormal_dopamine_level0.88584817
105MP0008058_abnormal_DNA_repair0.87645632
106MP0005394_taste/olfaction_phenotype0.87470707
107MP0005499_abnormal_olfactory_system0.87470707
108MP0001944_abnormal_pancreas_morphology0.86302499
109MP0001299_abnormal_eye_distance/0.84741181
110MP0002653_abnormal_ependyma_morphology0.84701449
111MP0002693_abnormal_pancreas_physiology0.84235623
112MP0003698_abnormal_male_reproductive0.83253326
113MP0005253_abnormal_eye_physiology0.83057755
114MP0000569_abnormal_digit_pigmentation0.82575878
115MP0002837_dystrophic_cardiac_calcinosis0.82548764
116MP0000003_abnormal_adipose_tissue0.82455012
117MP0002928_abnormal_bile_duct0.81527448
118MP0000653_abnormal_sex_gland0.80240337
119MP0003183_abnormal_peptide_metabolism0.79156099
120MP0000230_abnormal_systemic_arterial0.79125709
121MP0005167_abnormal_blood-brain_barrier0.76907631
122MP0005410_abnormal_fertilization0.75201901
123MP0008872_abnormal_physiological_respon0.75061527
124MP0002234_abnormal_pharynx_morphology0.74822224
125MP0002078_abnormal_glucose_homeostasis0.74430850
126MP0004085_abnormal_heartbeat0.73923997
127MP0001177_atelectasis0.72733260
128MP0004233_abnormal_muscle_weight0.72297449
129MP0002163_abnormal_gland_morphology0.69093554
130MP0002752_abnormal_somatic_nervous0.67392258
131MP0003632_abnormal_nervous_system0.65940463
132MP0002090_abnormal_vision0.65689908
133MP0008877_abnormal_DNA_methylation0.65497443
134MP0003075_altered_response_to0.64528616
135MP0003137_abnormal_impulse_conducting0.64077538
136MP0005623_abnormal_meninges_morphology0.63920760
137* MP0003953_abnormal_hormone_level0.63126296
138MP0000639_abnormal_adrenal_gland0.62267737

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.62666548
2Visual hallucinations (HP:0002367)5.44958490
3Myokymia (HP:0002411)5.21058726
4Focal seizures (HP:0007359)4.69994702
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.49019173
6Pancreatic cysts (HP:0001737)4.24530125
7Type II lissencephaly (HP:0007260)4.22914954
8Molar tooth sign on MRI (HP:0002419)4.14110866
9Abnormality of midbrain morphology (HP:0002418)4.14110866
10Supranuclear gaze palsy (HP:0000605)3.93118826
11Absence seizures (HP:0002121)3.77371898
12Pancreatic fibrosis (HP:0100732)3.75533848
13True hermaphroditism (HP:0010459)3.71384806
14Ankle clonus (HP:0011448)3.68980271
15Atonic seizures (HP:0010819)3.66275851
16Depression (HP:0000716)3.59586561
17Congenital stationary night blindness (HP:0007642)3.58687533
18Nephronophthisis (HP:0000090)3.54826221
19Papilledema (HP:0001085)3.53668138
20Generalized tonic-clonic seizures (HP:0002069)3.47811540
21Epileptic encephalopathy (HP:0200134)3.47442251
22Agitation (HP:0000713)3.44665831
23Progressive cerebellar ataxia (HP:0002073)3.43425111
24Dialeptic seizures (HP:0011146)3.32029221
25Action tremor (HP:0002345)3.22574425
26Anxiety (HP:0000739)3.21333636
27Febrile seizures (HP:0002373)3.15140400
28Postural instability (HP:0002172)3.12920285
29Abnormality of the renal medulla (HP:0100957)3.08821567
30Birth length less than 3rd percentile (HP:0003561)3.08095980
31Mutism (HP:0002300)3.06677226
32Abnormal eating behavior (HP:0100738)3.03283413
33Medial flaring of the eyebrow (HP:0010747)3.03066422
34Hyperventilation (HP:0002883)2.98778231
35Abnormality of the renal cortex (HP:0011035)2.93793219
36Cerebellar dysplasia (HP:0007033)2.93078340
37Failure to thrive in infancy (HP:0001531)2.89097065
38Insomnia (HP:0100785)2.86233947
39Lissencephaly (HP:0001339)2.80160538
40Abnormality of calcium-phosphate metabolism (HP:0100530)2.80070840
41Ventricular fibrillation (HP:0001663)2.78534022
42Anterior segment dysgenesis (HP:0007700)2.77604561
43Gait imbalance (HP:0002141)2.77189844
44Pheochromocytoma (HP:0002666)2.75855197
45Abnormality of the lower motor neuron (HP:0002366)2.74606107
46Truncal ataxia (HP:0002078)2.73488391
47Urinary bladder sphincter dysfunction (HP:0002839)2.73440458
48Menstrual irregularities (HP:0000858)2.72882988
49Impaired vibration sensation in the lower limbs (HP:0002166)2.71394180
50Hemiparesis (HP:0001269)2.69994205
51Inability to walk (HP:0002540)2.69214133
52Hypercortisolism (HP:0001578)2.65035299
53Hemiplegia (HP:0002301)2.64359210
54Neurofibrillary tangles (HP:0002185)2.62174428
55Chronic hepatic failure (HP:0100626)2.61244894
56Pendular nystagmus (HP:0012043)2.60699413
57Attenuation of retinal blood vessels (HP:0007843)2.59443712
58Dysdiadochokinesis (HP:0002075)2.59121606
59Cystic liver disease (HP:0006706)2.55742224
60Polyphagia (HP:0002591)2.54983771
61Congenital primary aphakia (HP:0007707)2.53776820
62Cerebral inclusion bodies (HP:0100314)2.50567694
63Spastic gait (HP:0002064)2.49013081
64Poor eye contact (HP:0000817)2.48982135
65Tubular atrophy (HP:0000092)2.48783165
66Abolished electroretinogram (ERG) (HP:0000550)2.48516307
67Large for gestational age (HP:0001520)2.47259858
68Neoplasm of the heart (HP:0100544)2.45990697
69Bradykinesia (HP:0002067)2.45809738
70EEG with generalized epileptiform discharges (HP:0011198)2.45406956
71Dysmetria (HP:0001310)2.43421547
72Genetic anticipation (HP:0003743)2.42548330
73Patellar aplasia (HP:0006443)2.42163560
74Impaired social interactions (HP:0000735)2.42111270
75Abnormal social behavior (HP:0012433)2.42111270
76Epileptiform EEG discharges (HP:0011182)2.38898637
77Retinal dysplasia (HP:0007973)2.37486817
78Hypsarrhythmia (HP:0002521)2.37380833
79Drooling (HP:0002307)2.37242612
80Excessive salivation (HP:0003781)2.37242612
81Polydipsia (HP:0001959)2.35492588
82Abnormal drinking behavior (HP:0030082)2.35492588
83Torticollis (HP:0000473)2.33037749
84Macroorchidism (HP:0000053)2.32573365
85Aplasia/Hypoplasia of the patella (HP:0006498)2.30742738
86Optic nerve hypoplasia (HP:0000609)2.29357547
87Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.29214859
88Neuroendocrine neoplasm (HP:0100634)2.28819870
89Nephrogenic diabetes insipidus (HP:0009806)2.28632759
90Progressive inability to walk (HP:0002505)2.28339095
91Duplicated collecting system (HP:0000081)2.26107829
92Limb dystonia (HP:0002451)2.25941321
93Impaired smooth pursuit (HP:0007772)2.25317553
94Hypoventilation (HP:0002791)2.22827844
95Abnormality of the pons (HP:0007361)2.21852845
96Clonus (HP:0002169)2.21314996
97Broad-based gait (HP:0002136)2.20348359
98Severe muscular hypotonia (HP:0006829)2.19363203
99Abnormality of the renal collecting system (HP:0004742)2.19354855
100Abnormality of the labia minora (HP:0012880)2.19279397
101Psychosis (HP:0000709)2.18722259
102Aplasia/Hypoplasia of the fovea (HP:0008060)2.18407655
103Hypoplasia of the fovea (HP:0007750)2.18407655
104Lower limb muscle weakness (HP:0007340)2.16837241
105Intention tremor (HP:0002080)2.16228473
106Aplasia/Hypoplasia of the tibia (HP:0005772)2.16039941
107Sclerocornea (HP:0000647)2.14888732
108Urinary urgency (HP:0000012)2.13928628
109Neuronal loss in central nervous system (HP:0002529)2.12929282
110Amblyopia (HP:0000646)2.08991020
111Abnormal EKG (HP:0003115)2.08335140
112Aplasia/Hypoplasia of the tongue (HP:0010295)2.07865932
113Megalencephaly (HP:0001355)2.07060663
114Genital tract atresia (HP:0001827)2.05961001
115Abnormal rod and cone electroretinograms (HP:0008323)2.05797969
116Chorioretinal atrophy (HP:0000533)2.03867953
117Hypoplasia of the pons (HP:0012110)2.03248081
118Focal dystonia (HP:0004373)2.02273880
119Anencephaly (HP:0002323)2.01938253
120Hyperparathyroidism (HP:0000843)1.99850468
121Abnormality of ocular smooth pursuit (HP:0000617)1.99692490
122Amyotrophic lateral sclerosis (HP:0007354)1.99465904
123Pachygyria (HP:0001302)1.98767429
124Postural tremor (HP:0002174)1.98429045
125Oligodactyly (hands) (HP:0001180)1.97678388
126Vaginal atresia (HP:0000148)1.96809834
127Status epilepticus (HP:0002133)1.96033490
128Renal cortical cysts (HP:0000803)1.95646361
129Hyperacusis (HP:0010780)1.94507514
130Postaxial foot polydactyly (HP:0001830)1.93106282
131Increased corneal curvature (HP:0100692)1.92336013
132Keratoconus (HP:0000563)1.92336013
133Abnormal respiratory motile cilium morphology (HP:0005938)1.91759665
134Abnormal respiratory epithelium morphology (HP:0012253)1.91759665
135Restlessness (HP:0000711)1.91022373
136Polyuria (HP:0000103)1.90266219
137Diplopia (HP:0000651)1.89675617
138Abnormality of binocular vision (HP:0011514)1.89675617
139Gaze-evoked nystagmus (HP:0000640)1.89624210
140Increased circulating renin level (HP:0000848)1.89249157
141Anosmia (HP:0000458)1.89211851
142Abnormality of alanine metabolism (HP:0010916)1.88609518
143Hyperalaninemia (HP:0003348)1.88609518
144Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88609518
145Craniofacial dystonia (HP:0012179)1.88435660
146Pointed chin (HP:0000307)1.87875161
147Ankyloglossia (HP:0010296)1.87790710
148Absent/shortened dynein arms (HP:0200106)1.87718356
149Dynein arm defect of respiratory motile cilia (HP:0012255)1.87718356
150Hyperinsulinemic hypoglycemia (HP:0000825)1.86883863
151Prolonged QT interval (HP:0001657)1.86246104
152Abnormality of the corticospinal tract (HP:0002492)1.86090934
153Adrenal overactivity (HP:0002717)1.85864697
154Resting tremor (HP:0002322)1.85130757
155Rapidly progressive (HP:0003678)1.83470006
156Bile duct proliferation (HP:0001408)1.83247569
157Abnormal biliary tract physiology (HP:0012439)1.83247569
158Aplasia/Hypoplasia of the sternum (HP:0006714)1.83100452
159Tetraplegia (HP:0002445)1.82450401
160Decreased circulating renin level (HP:0003351)1.82199648
161Poor coordination (HP:0002370)1.81343543
162Aplasia/Hypoplasia of the uvula (HP:0010293)1.80351169
163Congenital sensorineural hearing impairment (HP:0008527)1.79929717
164Hyperthyroidism (HP:0000836)1.79772130
165Scanning speech (HP:0002168)1.79612902
166Furrowed tongue (HP:0000221)1.79132181
167Methylmalonic acidemia (HP:0002912)1.79070566
168Rigidity (HP:0002063)1.78419328
169Blue irides (HP:0000635)1.78183441
170Aplasia/Hypoplasia involving the musculature (HP:0001460)1.77905253
171Absent thumb (HP:0009777)1.77863615
172Protruding tongue (HP:0010808)1.77824189
173Short tibia (HP:0005736)1.77451527
174Stomach cancer (HP:0012126)1.76965058
175Abnormality of the fovea (HP:0000493)1.76955851
176Congenital hepatic fibrosis (HP:0002612)1.76038819
177Male pseudohermaphroditism (HP:0000037)1.75938373
178Generalized myoclonic seizures (HP:0002123)1.75066322
179Postaxial hand polydactyly (HP:0001162)1.74744549
180Open mouth (HP:0000194)1.74463182
181Testicular neoplasm (HP:0010788)1.73769908
182Elfin facies (HP:0004428)1.73397107
183Ectopic kidney (HP:0000086)1.72365314
184Decreased central vision (HP:0007663)1.71579647
185Methylmalonic aciduria (HP:0012120)1.71258880
186Abnormal ciliary motility (HP:0012262)1.70419413
187Dandy-Walker malformation (HP:0001305)1.69480512
188Occipital encephalocele (HP:0002085)1.69250782

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.91052289
2FRK4.23093021
3MAP3K94.12677713
4BMPR1B3.67012721
5ACVR1B3.35896224
6MARK13.23745338
7ADRBK22.88745491
8MAP3K42.85942750
9NTRK22.74395015
10EPHA42.61292808
11ZAK2.61117443
12MINK12.57322841
13PRKD32.42060293
14PAK62.38978378
15NTRK12.34233394
16MAP4K22.33162059
17TLK12.23985489
18KSR22.15529701
19GRK12.10395044
20TAOK32.10329599
21UHMK12.04648895
22MAP2K71.93383236
23MAP3K121.79713548
24MAP2K41.78289580
25NUAK11.76495737
26CAMKK11.65858044
27TGFBR11.61297602
28PNCK1.57703408
29CDK51.52734163
30ARAF1.51470601
31MAP3K21.51454649
32STK391.50658374
33DAPK21.49290875
34OXSR11.48309432
35STK381.44871981
36NME11.42235963
37TNIK1.39352396
38KSR11.38498076
39ALK1.36782400
40MKNK21.30585108
41TRIM281.30286917
42TXK1.29319787
43TYRO31.28829914
44PRKCH1.27745385
45GRK51.27689092
46WNK31.25886025
47PAK31.23706227
48SCYL21.19675148
49PHKG21.17671013
50PHKG11.17671013
51FES1.17653045
52SIK21.16355999
53MAPK131.16137310
54INSRR1.15334932
55CDC42BPA1.12949544
56DYRK21.12450311
57MAP3K11.12239929
58PRKCG1.09698688
59MAP3K131.06303854
60TIE11.05390315
61LATS21.04828498
62ADRBK11.03508255
63TAOK11.01174683
64CDK191.00591576
65MAPK150.98972526
66STK38L0.98839806
67LMTK20.96231959
68TNK20.93202532
69VRK10.90953827
70HIPK20.90214731
71RET0.87378732
72CAMKK20.85949225
73STK110.85735294
74SGK2230.85367075
75SGK4940.85367075
76CDK140.83347291
77CDK150.82583565
78CDK180.81512052
79CSNK1G10.81395281
80TSSK60.80570058
81FER0.80347299
82DAPK10.79715782
83CAMK2A0.79378763
84PKN10.77794422
85CAMK1G0.77557519
86PLK20.76731432
87FGFR20.75301215
88CSNK1G30.75278130
89PRKCI0.74910663
90CDK11A0.72620499
91PINK10.71362883
92MARK20.71337188
93CAMK10.70711720
94PDGFRA0.70497078
95PLK30.69174502
96MST40.68289696
97NEK10.68146062
98DYRK1A0.67732513
99CSNK1A1L0.67362591
100CSNK1G20.66999125
101MAP2K60.64925493
102SGK30.63545010
103ICK0.63494624
104CAMK2B0.62420725
105BRSK10.62188494
106WNK10.62148297
107RIPK40.61992870
108SGK10.61858191
109RPS6KA30.60278551
110PTK2B0.59997549
111MUSK0.59832572
112SGK20.59606588
113MAPK100.59037130
114PRPF4B0.57205317
115MAPKAPK50.56633486
116BCKDK0.56329079
117MAPKAPK30.56326732
118NEK20.54462221
119WNK40.54315265
120PIK3CA0.54158707
121CASK0.52763057
122RIPK10.52085674
123CAMK2D0.52006774
124IRAK10.51639919
125CAMK1D0.49808036
126CSNK1D0.49800773
127BRSK20.49277666
128NEK60.48165550
129MAP2K20.48150716
130MAP2K10.48009513
131PASK0.47949254
132RPS6KA50.47692415
133WEE10.47353061
134RPS6KA20.47077585
135RAF10.46711705
136MKNK10.44757752
137PRKACA0.44736970
138PRKCZ0.44125175
139PRKCQ0.43501170
140PRKD20.42928799
141PDPK10.41916095
142NLK0.41483105
143CAMK2G0.41322100
144CSNK1A10.41303982
145BCR0.40404331
146PRKAA10.39032499
147PRKCE0.38926699
148DDR20.38769062
149CAMK40.38389941
150PDK10.37627068
151FYN0.37383895
152BRAF0.36408594
153PLK10.35348015
154CSNK1E0.34642652
155PRKCB0.33869571
156ERBB30.33785564
157TEC0.32451941
158CHUK0.31704276
159EPHA30.31013123
160AURKA0.30347461
161PRKG10.29965057

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.53353538
2Synaptic vesicle cycle_Homo sapiens_hsa047213.36516737
3* GABAergic synapse_Homo sapiens_hsa047272.96236497
4Insulin secretion_Homo sapiens_hsa049112.61379456
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.61267897
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.50221904
7Olfactory transduction_Homo sapiens_hsa047402.49792218
8Circadian entrainment_Homo sapiens_hsa047132.49418478
9Morphine addiction_Homo sapiens_hsa050322.44434087
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.40690576
11Linoleic acid metabolism_Homo sapiens_hsa005912.39804482
12Amphetamine addiction_Homo sapiens_hsa050312.33790316
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.33468299
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.33093314
15Glutamatergic synapse_Homo sapiens_hsa047242.26763593
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.25044893
17Long-term potentiation_Homo sapiens_hsa047202.24947113
18Cocaine addiction_Homo sapiens_hsa050302.12659335
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.09840937
20Dopaminergic synapse_Homo sapiens_hsa047282.07408318
21Taste transduction_Homo sapiens_hsa047421.93771692
22Caffeine metabolism_Homo sapiens_hsa002321.90883842
23Basal transcription factors_Homo sapiens_hsa030221.87511534
24Salivary secretion_Homo sapiens_hsa049701.86030989
25Oxidative phosphorylation_Homo sapiens_hsa001901.79664968
26Selenocompound metabolism_Homo sapiens_hsa004501.79660165
27Gastric acid secretion_Homo sapiens_hsa049711.79137861
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76808077
29Cholinergic synapse_Homo sapiens_hsa047251.76222193
30Type II diabetes mellitus_Homo sapiens_hsa049301.71330488
31Protein export_Homo sapiens_hsa030601.68407487
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66687519
33Tryptophan metabolism_Homo sapiens_hsa003801.63897321
34Serotonergic synapse_Homo sapiens_hsa047261.62527291
35Ether lipid metabolism_Homo sapiens_hsa005651.61089957
36Renin secretion_Homo sapiens_hsa049241.60517392
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58131643
38Fanconi anemia pathway_Homo sapiens_hsa034601.56504597
39RNA polymerase_Homo sapiens_hsa030201.54550800
40Homologous recombination_Homo sapiens_hsa034401.50509772
41Long-term depression_Homo sapiens_hsa047301.44252274
42GnRH signaling pathway_Homo sapiens_hsa049121.39860004
43ABC transporters_Homo sapiens_hsa020101.39220809
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.38931649
45Oxytocin signaling pathway_Homo sapiens_hsa049211.36482228
46Type I diabetes mellitus_Homo sapiens_hsa049401.36141036
47RNA degradation_Homo sapiens_hsa030181.35520348
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35490617
49Collecting duct acid secretion_Homo sapiens_hsa049661.33012530
50Gap junction_Homo sapiens_hsa045401.31948894
51Vibrio cholerae infection_Homo sapiens_hsa051101.31886519
52Nitrogen metabolism_Homo sapiens_hsa009101.31029514
53Estrogen signaling pathway_Homo sapiens_hsa049151.29925448
54Calcium signaling pathway_Homo sapiens_hsa040201.27312473
55Parkinsons disease_Homo sapiens_hsa050121.27083906
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24953031
57cAMP signaling pathway_Homo sapiens_hsa040241.19351716
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17805788
59Propanoate metabolism_Homo sapiens_hsa006401.14648623
60Regulation of autophagy_Homo sapiens_hsa041401.13274739
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13124785
62Dorso-ventral axis formation_Homo sapiens_hsa043201.01709651
63Melanogenesis_Homo sapiens_hsa049161.01112373
64Thyroid hormone synthesis_Homo sapiens_hsa049181.00559581
65Pancreatic secretion_Homo sapiens_hsa049720.99869302
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99641822
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98781258
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97919485
69Peroxisome_Homo sapiens_hsa041460.94500354
70Cardiac muscle contraction_Homo sapiens_hsa042600.91839516
71Glioma_Homo sapiens_hsa052140.90422569
72ErbB signaling pathway_Homo sapiens_hsa040120.87272484
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86039271
74Axon guidance_Homo sapiens_hsa043600.85878360
75Huntingtons disease_Homo sapiens_hsa050160.85702342
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.85491735
77Oocyte meiosis_Homo sapiens_hsa041140.85144230
78Prion diseases_Homo sapiens_hsa050200.84443639
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83069229
80Chemical carcinogenesis_Homo sapiens_hsa052040.81673937
81Alzheimers disease_Homo sapiens_hsa050100.81580808
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80045631
83beta-Alanine metabolism_Homo sapiens_hsa004100.79869462
84Alcoholism_Homo sapiens_hsa050340.79508888
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.78843136
86Glycerolipid metabolism_Homo sapiens_hsa005610.76349279
87Glucagon signaling pathway_Homo sapiens_hsa049220.75100061
88Arachidonic acid metabolism_Homo sapiens_hsa005900.74422249
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74000129
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73310453
91Dilated cardiomyopathy_Homo sapiens_hsa054140.71385674
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.70524678
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69097988
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67232379
95Bile secretion_Homo sapiens_hsa049760.66850155
96MAPK signaling pathway_Homo sapiens_hsa040100.66023139
97One carbon pool by folate_Homo sapiens_hsa006700.65723110
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64796089
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.63891994
100Histidine metabolism_Homo sapiens_hsa003400.63813991
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.63207319
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.62159174
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61458147
104Retinol metabolism_Homo sapiens_hsa008300.61441569
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60732511
106Phototransduction_Homo sapiens_hsa047440.60532216
107mTOR signaling pathway_Homo sapiens_hsa041500.58184341
108Insulin signaling pathway_Homo sapiens_hsa049100.57961540
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56737560
110Circadian rhythm_Homo sapiens_hsa047100.54613074
111Purine metabolism_Homo sapiens_hsa002300.54165130
112Choline metabolism in cancer_Homo sapiens_hsa052310.53774806
113Mineral absorption_Homo sapiens_hsa049780.53273457
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52502405
115Primary immunodeficiency_Homo sapiens_hsa053400.52262353
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52151365
117Arginine and proline metabolism_Homo sapiens_hsa003300.51745954
118Ovarian steroidogenesis_Homo sapiens_hsa049130.50430516
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49687309
120Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48390013
121Metabolic pathways_Homo sapiens_hsa011000.48057060
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47721628
123Inositol phosphate metabolism_Homo sapiens_hsa005620.46983466
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.46946550
125Ras signaling pathway_Homo sapiens_hsa040140.46926294
126Endocytosis_Homo sapiens_hsa041440.46748143
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46338622
128Endometrial cancer_Homo sapiens_hsa052130.45405865
129Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44177096
130Steroid biosynthesis_Homo sapiens_hsa001000.43950511
131Renal cell carcinoma_Homo sapiens_hsa052110.43931416
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43783152
133Lysine degradation_Homo sapiens_hsa003100.42950284
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42541777
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42113237
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40300564
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39396032
138VEGF signaling pathway_Homo sapiens_hsa043700.38786079
139SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38329794
140Fat digestion and absorption_Homo sapiens_hsa049750.37827124
141Wnt signaling pathway_Homo sapiens_hsa043100.37517157
142Prolactin signaling pathway_Homo sapiens_hsa049170.35435211
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.35179622
144Hedgehog signaling pathway_Homo sapiens_hsa043400.35070462
145Rap1 signaling pathway_Homo sapiens_hsa040150.33905470
146Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33397846
147Butanoate metabolism_Homo sapiens_hsa006500.32641307
148Sphingolipid signaling pathway_Homo sapiens_hsa040710.31023785
149Basal cell carcinoma_Homo sapiens_hsa052170.30237281
150Non-small cell lung cancer_Homo sapiens_hsa052230.30145991
151Sulfur relay system_Homo sapiens_hsa041220.29794205
152Lysosome_Homo sapiens_hsa041420.29785170
153Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28546040
154Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28211091
155Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27688181
156Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24787463

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