HAPLN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1somite rostral/caudal axis specification (GO:0032525)9.62668498
2limb bud formation (GO:0060174)8.72078131
3notochord development (GO:0030903)8.71286711
4negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)8.22157184
5positive regulation of extracellular matrix organization (GO:1903055)8.18105337
6aggressive behavior (GO:0002118)7.64952197
7sphingomyelin metabolic process (GO:0006684)7.56334739
8apical protein localization (GO:0045176)7.11052950
9endoderm formation (GO:0001706)6.95824365
10collagen fibril organization (GO:0030199)6.89613214
11proteoglycan metabolic process (GO:0006029)6.42368280
12anterior/posterior axis specification (GO:0009948)6.29429458
13cartilage development (GO:0051216)6.10380950
14nucleotide-sugar biosynthetic process (GO:0009226)6.05154815
15chondroitin sulfate biosynthetic process (GO:0030206)5.98261237
16phospholipid scrambling (GO:0017121)5.83201612
17endochondral ossification (GO:0001958)5.80956390
18replacement ossification (GO:0036075)5.80956390
19behavioral response to ethanol (GO:0048149)5.59983779
20embryonic skeletal joint morphogenesis (GO:0060272)5.58186885
21cellular glucuronidation (GO:0052695)5.57930688
22regulation of extracellular matrix disassembly (GO:0010715)5.47677989
23negative regulation of gluconeogenesis (GO:0045721)5.47522294
24chondrocyte differentiation (GO:0002062)5.46384825
25protein retention in ER lumen (GO:0006621)5.35571547
26ventricular cardiac muscle cell development (GO:0055015)5.32349151
27keratan sulfate biosynthetic process (GO:0018146)5.32148496
28endothelial cell morphogenesis (GO:0001886)5.13725235
29regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901215.06196577
30primitive streak formation (GO:0090009)5.01657755
31regulation of mesoderm development (GO:2000380)4.99905244
32uronic acid metabolic process (GO:0006063)4.98453240
33glucuronate metabolic process (GO:0019585)4.98453240
34maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.94626027
35iron ion import (GO:0097286)4.90228046
36collagen catabolic process (GO:0030574)4.88544847
37protein localization to kinetochore (GO:0034501)4.82893914
38regulation of extracellular matrix organization (GO:1903053)4.82785757
39skeletal system development (GO:0001501)4.77952949
40embryonic axis specification (GO:0000578)4.73497476
41negative regulation of receptor activity (GO:2000272)4.70134302
42endocardial cushion morphogenesis (GO:0003203)4.69684202
43positive regulation of chondrocyte differentiation (GO:0032332)4.68874076
44synaptic transmission, dopaminergic (GO:0001963)4.67815725
45short-term memory (GO:0007614)4.66219988
46CENP-A containing nucleosome assembly (GO:0034080)4.61077527
47collagen metabolic process (GO:0032963)4.60733559
48regulation of plasminogen activation (GO:0010755)4.59026690
49sequestering of extracellular ligand from receptor (GO:0035581)4.58966132
50mitotic G2/M transition checkpoint (GO:0044818)4.54554436
51negative regulation of activin receptor signaling pathway (GO:0032926)4.50161833
52multicellular organismal catabolic process (GO:0044243)4.47136245
53segment specification (GO:0007379)4.45834309
54hypotonic response (GO:0006971)4.37444394
55establishment of endothelial barrier (GO:0061028)4.36679923
56regulation of type B pancreatic cell apoptotic process (GO:2000674)4.32989323
57lipopolysaccharide biosynthetic process (GO:0009103)4.32954694
58asymmetric protein localization (GO:0008105)4.32243281
59protein neddylation (GO:0045116)4.31250881
60multicellular organismal macromolecule metabolic process (GO:0044259)4.30216160
61keratan sulfate metabolic process (GO:0042339)4.29210273
62chromatin remodeling at centromere (GO:0031055)4.24495751
63detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.22316180
64negative regulation of smooth muscle cell differentiation (GO:0051151)4.21601452
65positive regulation of cartilage development (GO:0061036)4.20218490
66DNA ligation (GO:0006266)4.18984191
67peptidyl-proline hydroxylation (GO:0019511)4.16468444
68mitotic G2 DNA damage checkpoint (GO:0007095)4.15702518
69cellular response to estradiol stimulus (GO:0071392)4.15514982
70glycoprotein metabolic process (GO:0009100)4.15214127
71COPII vesicle coating (GO:0048208)4.11905482
72multicellular organismal metabolic process (GO:0044236)4.10961050
73connective tissue development (GO:0061448)4.09855250
74bone morphogenesis (GO:0060349)4.08331562
75cell migration involved in gastrulation (GO:0042074)4.07898096
76gastrulation (GO:0007369)4.07420192
77response to BMP (GO:0071772)4.05467659
78cellular response to BMP stimulus (GO:0071773)4.05467659
79proteasome assembly (GO:0043248)4.03565783
80female gonad development (GO:0008585)4.00614360
81UDP-N-acetylglucosamine metabolic process (GO:0006047)3.93899785
82cardiac epithelial to mesenchymal transition (GO:0060317)3.91502664
83uterus development (GO:0060065)3.90106354
84inositol metabolic process (GO:0006020)3.87662592
85histone exchange (GO:0043486)3.86022186
86glycosaminoglycan biosynthetic process (GO:0006024)3.83726981
87response to gravity (GO:0009629)3.79939031
88aminoglycan biosynthetic process (GO:0006023)3.78634930
89myelin assembly (GO:0032288)3.74121955
90anterior/posterior axis specification, embryo (GO:0008595)3.73091655
91extracellular matrix disassembly (GO:0022617)3.68722944
92chondroitin sulfate metabolic process (GO:0030204)3.68283560
93cranial suture morphogenesis (GO:0060363)3.67408008
94cellular response to ammonium ion (GO:0071242)3.65413320
95positive regulation of hormone biosynthetic process (GO:0046886)3.62972815
96lipopolysaccharide metabolic process (GO:0008653)3.61960209
97positive regulation of cardiac muscle tissue development (GO:0055025)3.59045406
98signal transduction involved in regulation of gene expression (GO:0023019)3.54724916
99negative regulation of chemokine production (GO:0032682)3.53601198
100branch elongation of an epithelium (GO:0060602)3.51836662
101axis specification (GO:0009798)3.47741550
102cell surface receptor signaling pathway involved in heart development (GO:0061311)3.46263956
103endothelial cell proliferation (GO:0001935)3.45862370
104mesenchyme morphogenesis (GO:0072132)3.45847270
105atrial cardiac muscle cell action potential (GO:0086014)3.44312400
106regulation of chondrocyte differentiation (GO:0032330)3.43837735
107positive regulation of gastrulation (GO:2000543)3.43811495
108regulation of cell maturation (GO:1903429)3.43787874
109sulfur compound catabolic process (GO:0044273)3.43466661
110glycosaminoglycan catabolic process (GO:0006027)3.43446428
111negative regulation of embryonic development (GO:0045992)3.42856189
112glomerulus development (GO:0032835)3.41992865
113DNA topological change (GO:0006265)3.40803647
114outflow tract septum morphogenesis (GO:0003148)3.39731602
115negative regulation of axon extension involved in axon guidance (GO:0048843)3.34803013
116otic vesicle formation (GO:0030916)3.34583365
117nucleotide-sugar metabolic process (GO:0009225)3.34292931
118positive regulation of cardiac muscle cell proliferation (GO:0060045)3.32732352
119protein localization to chromosome, centromeric region (GO:0071459)3.30839131
120kinetochore organization (GO:0051383)3.30561178
121endodermal cell differentiation (GO:0035987)3.29510360
122DNA replication-independent nucleosome organization (GO:0034724)3.28085524
123DNA replication-independent nucleosome assembly (GO:0006336)3.28085524
124regulation of steroid hormone biosynthetic process (GO:0090030)3.27453806
125regulation of cartilage development (GO:0061035)3.25857403
126aminoglycan catabolic process (GO:0006026)3.24009576
127protein hydroxylation (GO:0018126)3.22418404
128regulation of cardioblast differentiation (GO:0051890)3.21364643
129positive regulation of SMAD protein import into nucleus (GO:0060391)3.16979836
130negative regulation of glycogen biosynthetic process (GO:0045719)3.16793416
131negative regulation of NF-kappaB import into nucleus (GO:0042347)3.16574616
132vascular endothelial growth factor signaling pathway (GO:0038084)3.14834650
133mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.14257060
134regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.13732748
135negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.12093102
136proteoglycan biosynthetic process (GO:0030166)3.11066628
137negative regulation of cell fate specification (GO:0009996)3.09827970
138Rap protein signal transduction (GO:0032486)3.08352850
139organ formation (GO:0048645)3.07976296
140embryonic pattern specification (GO:0009880)3.07086852
141negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.05857353
142substrate adhesion-dependent cell spreading (GO:0034446)3.05772091
143regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.05256950
144endothelium development (GO:0003158)3.05155196
145ossification (GO:0001503)3.03101813
146embryonic foregut morphogenesis (GO:0048617)3.02668247
147endocardial cushion development (GO:0003197)3.02578027
148axon extension involved in axon guidance (GO:0048846)3.00712301
149neuron projection extension involved in neuron projection guidance (GO:1902284)3.00712301
150DNA replication-dependent nucleosome assembly (GO:0006335)2.99879183
151DNA replication-dependent nucleosome organization (GO:0034723)2.99879183
152positive regulation of urine volume (GO:0035810)2.99512345
153regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.98692865
154phagocytosis, engulfment (GO:0006911)2.98653227
155cellular response to estrogen stimulus (GO:0071391)2.98172652
156regulation of gastrulation (GO:0010470)2.97291194
157wound healing, spreading of epidermal cells (GO:0035313)2.97093064
158regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.96999051
159regulation of mitotic spindle checkpoint (GO:1903504)2.96999051
160embryonic viscerocranium morphogenesis (GO:0048703)2.96962570
161negative regulation of glycogen metabolic process (GO:0070874)2.96670822
162DNA replication checkpoint (GO:0000076)2.96653039
163ureteric bud development (GO:0001657)2.94677907
164replication fork processing (GO:0031297)2.94174642
165mucopolysaccharide metabolic process (GO:1903510)2.93981366
166dorsal/ventral axis specification (GO:0009950)2.91403785
167inositol phosphate-mediated signaling (GO:0048016)2.91162539
168regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393)2.90463034
169branched-chain amino acid catabolic process (GO:0009083)2.89995881
170negative regulation of cartilage development (GO:0061037)2.89639593
171positive regulation of cardiac muscle tissue growth (GO:0055023)2.88078574
172Golgi transport vesicle coating (GO:0048200)2.86769768
173COPI coating of Golgi vesicle (GO:0048205)2.86769768
174positive regulation of hair follicle development (GO:0051798)2.86336549
175positive regulation of hair cycle (GO:0042635)2.86336549
176positive regulation of striated muscle tissue development (GO:0045844)2.84993754
177positive regulation of muscle organ development (GO:0048636)2.84993754
178positive regulation of cardiac muscle cell differentiation (GO:2000727)2.84492205
179heart valve formation (GO:0003188)2.81484954
180hyperosmotic salinity response (GO:0042538)2.81240665
181regulation of integrin-mediated signaling pathway (GO:2001044)2.81195264
182positive regulation of male gonad development (GO:2000020)2.81095995
183* extracellular matrix organization (GO:0030198)2.80277809
184positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.80245492
185* extracellular structure organization (GO:0043062)2.79545721
186regulation of bone mineralization (GO:0030500)2.78166293
187protein K11-linked deubiquitination (GO:0035871)2.78134136
188positive regulation of endothelial cell differentiation (GO:0045603)2.77097822
189regulation of response to osmotic stress (GO:0047484)2.76127528
190cartilage development involved in endochondral bone morphogenesis (GO:0060351)12.9225870
191cell aggregation (GO:0098743)11.9556188
192cartilage condensation (GO:0001502)11.9556188
193chondrocyte development (GO:0002063)11.5304163
194keratan sulfate catabolic process (GO:0042340)11.3674201

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.31149153
2AR_21572438_ChIP-Seq_LNCaP_Human5.76010272
3* TRIM28_21343339_ChIP-Seq_HEK293_Human5.47489809
4SMAD_19615063_ChIP-ChIP_OVARY_Human4.48950947
5GATA1_22025678_ChIP-Seq_K562_Human3.53073173
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.36014118
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.22910614
8ESR1_21235772_ChIP-Seq_MCF-7_Human3.20463417
9SMAD3_21741376_ChIP-Seq_HESCs_Human2.92400527
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.90798585
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.88719321
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.69269279
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.61248773
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.61248773
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.61248773
16AR_21909140_ChIP-Seq_LNCAP_Human2.60752187
17ELK1_19687146_ChIP-ChIP_HELA_Human2.50989885
18EWS_26573619_Chip-Seq_HEK293_Human2.49991765
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.29621708
20HIF1A_21447827_ChIP-Seq_MCF-7_Human2.26875454
21HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.26513396
22EOMES_21245162_ChIP-Seq_HESCs_Human2.24998182
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.23873602
24ESR2_21235772_ChIP-Seq_MCF-7_Human2.22719858
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.16939769
26E2F4_17652178_ChIP-ChIP_JURKAT_Human2.16614864
27SMAD4_21741376_ChIP-Seq_HESCs_Human2.10273603
28SALL1_21062744_ChIP-ChIP_HESCs_Human2.09530027
29VDR_22108803_ChIP-Seq_LS180_Human2.04710939
30CJUN_26792858_Chip-Seq_BT549_Human2.03891723
31FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.98320075
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.97693269
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.97656478
34ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.97626162
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.94893622
36* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93446752
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89961367
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.89753572
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.83782106
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.80258767
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.77687002
42NANOG_16153702_ChIP-ChIP_HESCs_Human1.77486069
43RXR_22108803_ChIP-Seq_LS180_Human1.76351488
44TAF15_26573619_Chip-Seq_HEK293_Human1.76040118
45RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.73195301
46TP53_18474530_ChIP-ChIP_U2OS_Human1.71070235
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.70295197
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68130171
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65830435
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65092091
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62413323
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.53770439
53SMAD4_21741376_ChIP-Seq_EPCs_Human1.53614579
54FUS_26573619_Chip-Seq_HEK293_Human1.50094935
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48530616
56VDR_24787735_ChIP-Seq_THP-1_Human1.48063043
57SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47504764
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.46482889
59JARID2_20064375_ChIP-Seq_MESCs_Mouse1.46137356
60EGR1_19032775_ChIP-ChIP_M12_Human1.44755229
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44510742
62TCF3_18692474_ChIP-Seq_MEFs_Mouse1.43091521
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.42677203
64CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.42361945
65RNF2_27304074_Chip-Seq_NSC_Mouse1.41343749
66JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41051005
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37402985
68RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37355052
69EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37355052
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37336538
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36629551
72FOXM1_26456572_ChIP-Seq_MCF-7_Human1.36529234
73CREB1_15753290_ChIP-ChIP_HEK293T_Human1.32049653
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31443442
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30517401
76SOX2_20726797_ChIP-Seq_SW620_Human1.28639129
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28213831
78SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28118328
79* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28101681
80* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28101681
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.27630160
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27229824
83ISL1_27105846_Chip-Seq_CPCs_Mouse1.26794214
84SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26390400
85JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25525086
86TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25277167
87RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25119448
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24368827
89SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22628930
90JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22343177
91* SMAD3_21741376_ChIP-Seq_EPCs_Human1.21581795
92TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.21148202
93ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21114068
94GBX2_23144817_ChIP-Seq_PC3_Human1.21073404
95* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19443947
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.19375736
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18143760
98* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17139659
99* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17139659
100ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.15791163
101ELK1_22589737_ChIP-Seq_MCF10A_Human1.15783377
102CLOCK_20551151_ChIP-Seq_293T_Human1.15154428
103POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14914555
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14846854
105BCAT_22108803_ChIP-Seq_LS180_Human1.13511330
106NANOG_18555785_Chip-Seq_ESCs_Mouse1.13403439
107BRD4_25478319_ChIP-Seq_HGPS_Human1.12850662
108SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12605522
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.11855659
110TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11487713
111TBX3_20139965_ChIP-Seq_MESCs_Mouse1.11078519
112ZNF274_21170338_ChIP-Seq_K562_Hela1.10110368
113CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09948699
114PIAS1_25552417_ChIP-Seq_VCAP_Human1.07306463
115* GATA3_24758297_ChIP-Seq_MCF-7_Human1.07171117
116* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07075337
117EST1_17652178_ChIP-ChIP_JURKAT_Human1.07062121
118FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06456417
119REST_19997604_ChIP-ChIP_NEURONS_Mouse1.06336771
120TCF4_22108803_ChIP-Seq_LS180_Human1.06288173
121NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05216134
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05061817
123PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03586776
124* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02364562
125RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02153729
126SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01672371
127SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01672371
128RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01341355
129NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.01331679
130P53_22387025_ChIP-Seq_ESCs_Mouse1.01190474
131SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00175106
132KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99841752
133TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98171543
134ESR1_20079471_ChIP-ChIP_T-47D_Human0.98009603
135CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97411814
136* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97396893
137CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96046953
138RNF2_27304074_Chip-Seq_ESCs_Mouse0.95967293
139HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95882890
140BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95416215
141MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95379332
142TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94986580
143SMAD4_21799915_ChIP-Seq_A2780_Human0.93840197
144* SA1_22415368_ChIP-Seq_MEFs_Mouse0.93762549
145NANOG_19829295_ChIP-Seq_ESCs_Human0.92889815
146SOX2_19829295_ChIP-Seq_ESCs_Human0.92889815
147STAT3_18555785_Chip-Seq_ESCs_Mouse0.92141518
148P300_19829295_ChIP-Seq_ESCs_Human0.91732924
149MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91545425
150ERG_21242973_ChIP-ChIP_JURKAT_Human0.90959641
151SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.90901905
152NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90603918
153FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.90530093
154SOX17_20123909_ChIP-Seq_XEN_Mouse0.90446741
155MYC_18940864_ChIP-ChIP_HL60_Human0.89206158
156E2F1_18555785_Chip-Seq_ESCs_Mouse0.87206204
157TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86384858
158TP53_20018659_ChIP-ChIP_R1E_Mouse0.85638609
159SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.85260568
160EP300_21415370_ChIP-Seq_HL-1_Mouse0.85173997
161ER_23166858_ChIP-Seq_MCF-7_Human0.84511655

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry7.35362332
2MP0002933_joint_inflammation6.08816930
3MP0004134_abnormal_chest_morphology5.82963956
4MP0002282_abnormal_trachea_morphology5.63253656
5MP0003123_paternal_imprinting4.32057412
6MP0003646_muscle_fatigue4.12648865
7* MP0000163_abnormal_cartilage_morphology3.96664782
8MP0005503_abnormal_tendon_morphology3.82452117
9MP0009780_abnormal_chondrocyte_physiolo3.72886711
10* MP0009250_abnormal_appendicular_skeleto3.34742963
11MP0003787_abnormal_imprinting3.25646439
12* MP0002115_abnormal_skeleton_extremities3.20398907
13MP0010368_abnormal_lymphatic_system3.18791979
14MP0002163_abnormal_gland_morphology3.15330656
15MP0002909_abnormal_adrenal_gland2.85694818
16MP0002089_abnormal_postnatal_growth/wei2.73117677
17MP0002254_reproductive_system_inflammat2.70528075
18* MP0002113_abnormal_skeleton_development2.65645158
19MP0001485_abnormal_pinna_reflex2.65552099
20MP0000762_abnormal_tongue_morphology2.60995143
21MP0001270_distended_abdomen2.56875457
22MP0001879_abnormal_lymphatic_vessel2.50831468
23MP0002896_abnormal_bone_mineralization2.50633833
24MP0003656_abnormal_erythrocyte_physiolo2.48623657
25MP0001299_abnormal_eye_distance/2.46523858
26MP0000516_abnormal_urinary_system2.40585003
27MP0005367_renal/urinary_system_phenotyp2.40585003
28MP0001533_abnormal_skeleton_physiology2.23828492
29MP0002109_abnormal_limb_morphology2.17305045
30MP0009384_cardiac_valve_regurgitation2.13042166
31MP0001915_intracranial_hemorrhage2.03624085
32MP0006054_spinal_hemorrhage10.4471796
33MP0003283_abnormal_digestive_organ1.92387390
34MP0003795_abnormal_bone_structure1.89653735
35MP0000537_abnormal_urethra_morphology1.85519352
36* MP0005390_skeleton_phenotype1.82853891
37MP0005379_endocrine/exocrine_gland_phen1.81231284
38MP0003755_abnormal_palate_morphology1.74110766
39MP0005257_abnormal_intraocular_pressure1.72587525
40MP0003121_genomic_imprinting1.72449099
41MP0008004_abnormal_stomach_pH1.70623666
42MP0002084_abnormal_developmental_patter1.64626678
43MP0000751_myopathy1.62608196
44MP0005380_embryogenesis_phenotype1.60508979
45MP0001672_abnormal_embryogenesis/_devel1.60508979
46MP0009697_abnormal_copulation1.52709798
47MP0001542_abnormal_bone_strength1.51227825
48* MP0005508_abnormal_skeleton_morphology1.49814864
49MP0003315_abnormal_perineum_morphology1.43155750
50MP0005623_abnormal_meninges_morphology1.40627205
51MP0003984_embryonic_growth_retardation1.40364674
52* MP0002116_abnormal_craniofacial_bone1.39917478
53MP0005394_taste/olfaction_phenotype1.38495288
54MP0005499_abnormal_olfactory_system1.38495288
55MP0001663_abnormal_digestive_system1.37069378
56MP0002088_abnormal_embryonic_growth/wei1.35669204
57MP0004957_abnormal_blastocyst_morpholog1.33373852
58MP0004484_altered_response_of1.28477202
59MP0003122_maternal_imprinting1.28348886
60MP0002102_abnormal_ear_morphology1.27348546
61MP0000343_altered_response_to1.27097919
62MP0001293_anophthalmia1.25922394
63MP0005381_digestive/alimentary_phenotyp1.25900781
64MP0005084_abnormal_gallbladder_morpholo1.25509122
65MP0010094_abnormal_chromosome_stability1.25016994
66MP0003943_abnormal_hepatobiliary_system1.21382083
67MP0001730_embryonic_growth_arrest1.20927521
68MP0004272_abnormal_basement_membrane1.20492322
69MP0003436_decreased_susceptibility_to1.17814680
70MP0002086_abnormal_extraembryonic_tissu1.17600963
71MP0005076_abnormal_cell_differentiation1.15447481
72MP0002085_abnormal_embryonic_tissue1.15410831
73MP0003385_abnormal_body_wall1.13832270
74MP0003567_abnormal_fetal_cardiomyocyte1.11795913
75MP0002111_abnormal_tail_morphology1.10568913
76MP0008438_abnormal_cutaneous_collagen1.09911089
77MP0002108_abnormal_muscle_morphology1.05925638
78* MP0000432_abnormal_head_morphology1.05531031
79MP0002877_abnormal_melanocyte_morpholog1.05109184
80MP0008932_abnormal_embryonic_tissue1.04388631
81MP0004197_abnormal_fetal_growth/weight/1.02921139
82MP0005197_abnormal_uvea_morphology1.02491065
83MP0003937_abnormal_limbs/digits/tail_de1.01359879
84MP0002233_abnormal_nose_morphology0.98552431
85* MP0002114_abnormal_axial_skeleton0.98494508
86MP0001697_abnormal_embryo_size0.97800168
87MP0003566_abnormal_cell_adhesion0.97697754
88MP0004215_abnormal_myocardial_fiber0.97692254
89MP0002925_abnormal_cardiovascular_devel0.97021733
90MP0002127_abnormal_cardiovascular_syste0.97020942
91MP0000534_abnormal_ureter_morphology0.96900340
92MP0002998_abnormal_bone_remodeling0.92259311
93MP0004084_abnormal_cardiac_muscle0.91931345
94MP0003806_abnormal_nucleotide_metabolis0.91561384
95MP0002139_abnormal_hepatobiliary_system0.91463160
96MP0009053_abnormal_anal_canal0.90859699
97MP0005275_abnormal_skin_tensile0.90086183
98MP0000767_abnormal_smooth_muscle0.89859811
99MP0002249_abnormal_larynx_morphology0.89367283
100MP0003279_aneurysm0.89151226
101* MP0003935_abnormal_craniofacial_develop0.89072347
102MP0000465_gastrointestinal_hemorrhage0.87039997
103MP0002735_abnormal_chemical_nociception0.85350265
104MP0000372_irregular_coat_pigmentation0.85107428
105MP0006072_abnormal_retinal_apoptosis0.83617224
106MP0001963_abnormal_hearing_physiology0.82997915
107MP0005171_absent_coat_pigmentation0.82930514
108MP0005023_abnormal_wound_healing0.81385698
109MP0008058_abnormal_DNA_repair0.80314575
110MP0003942_abnormal_urinary_system0.79549339
111MP0004133_heterotaxia0.79161424
112MP0008057_abnormal_DNA_replication0.78864372
113MP0005164_abnormal_response_to0.75954079
114MP0008789_abnormal_olfactory_epithelium0.73757666
115MP0005187_abnormal_penis_morphology0.73279669
116MP0010030_abnormal_orbit_morphology0.73111656
117MP0003091_abnormal_cell_migration0.72413643
118MP0002697_abnormal_eye_size0.72406738
119MP0005166_decreased_susceptibility_to0.71149212
120MP0003119_abnormal_digestive_system0.70912522
121MP0001119_abnormal_female_reproductive0.68056638
122MP0005083_abnormal_biliary_tract0.67970963
123MP0003195_calcinosis0.67415877
124MP0002080_prenatal_lethality0.67379400
125MP0003950_abnormal_plasma_membrane0.67358425
126MP0001943_abnormal_respiration0.66846990
127MP0005193_abnormal_anterior_eye0.66504463
128MP0003077_abnormal_cell_cycle0.64847689
129MP0002128_abnormal_blood_circulation0.64796836
130MP0003221_abnormal_cardiomyocyte_apopto0.63193439
131MP0002177_abnormal_outer_ear0.61013373
132MP0001177_atelectasis0.59416538
133MP0000266_abnormal_heart_morphology0.57790115
134MP0002932_abnormal_joint_morphology0.56593348
135MP0001286_abnormal_eye_development0.54957307
136MP0003868_abnormal_feces_composition0.54475002
137MP0001784_abnormal_fluid_regulation0.53364263
138MP0001873_stomach_inflammation0.53028468
139MP0002133_abnormal_respiratory_system0.52649420
140MP0005388_respiratory_system_phenotype0.52649420
141MP0003938_abnormal_ear_development0.51435086
142MP0001666_abnormal_nutrient_absorption0.49985328
143MP0003705_abnormal_hypodermis_morpholog0.49091304
144MP0001958_emphysema0.46463477
145MP0000749_muscle_degeneration0.46380614
146MP0000230_abnormal_systemic_arterial0.45737375
147MP0005248_abnormal_Harderian_gland0.43328307
148MP0003075_altered_response_to0.42221278
149MP0000462_abnormal_digestive_system0.42014413
150MP0005646_abnormal_pituitary_gland0.40354017
151* MP0000049_abnormal_middle_ear0.38031158
152MP0004036_abnormal_muscle_relaxation0.37915827
153MP0000428_abnormal_craniofacial_morphol0.36304324
154MP0004185_abnormal_adipocyte_glucose0.35314225
155MP0002138_abnormal_hepatobiliary_system0.35189971
156MP0008775_abnormal_heart_ventricle0.35050232
157MP0002736_abnormal_nociception_after0.34236057
158MP0002972_abnormal_cardiac_muscle0.32400502
159MP0000427_abnormal_hair_cycle0.31405108
160MP0000026_abnormal_inner_ear0.29806457
161MP0003941_abnormal_skin_development0.28051742
162MP0005595_abnormal_vascular_smooth0.27902947
163MP0000639_abnormal_adrenal_gland0.27694049
164MP0006276_abnormal_autonomic_nervous0.27462897

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)9.93451012
2Irregular epiphyses (HP:0010582)9.47315502
3Vitreoretinal degeneration (HP:0000655)7.99569663
4Cupped ribs (HP:0000887)6.66680707
5Hypoplastic ischia (HP:0003175)6.60571772
6Small epiphyses (HP:0010585)6.53635607
7Abnormal tarsal ossification (HP:0008369)6.47100915
8Abnormality of the fetal cardiovascular system (HP:0010948)6.13089786
9Abnormal umbilical cord blood vessels (HP:0011403)6.13089786
10Single umbilical artery (HP:0001195)6.13089786
11Abnormality of the ischium (HP:0003174)5.84792216
12Aplasia/Hypoplasia of the pubic bone (HP:0009104)5.84000812
13Flat acetabular roof (HP:0003180)5.48836663
14Flat capital femoral epiphysis (HP:0003370)5.44745473
15Genu varum (HP:0002970)5.29116380
16Metaphyseal dysplasia (HP:0100255)5.07869640
17Metaphyseal cupping (HP:0003021)4.93510955
18Delayed epiphyseal ossification (HP:0002663)4.87146500
19Abnormality involving the epiphyses of the lower limbs (HP:0006500)4.81870214
20Abnormality of femoral epiphyses (HP:0006499)4.81870214
21Abnormal foot bone ossification (HP:0010675)4.75664502
22Abnormal pancreas size (HP:0012094)4.70073455
23Abnormality of the vertebral endplates (HP:0005106)4.63402258
24Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)4.51334922
25Absent epiphyses (HP:0010577)4.51334922
26Arthropathy (HP:0003040)4.43900564
27Gonadal dysgenesis (HP:0000133)4.43185308
28Ankyloglossia (HP:0010296)4.40407485
29Flattened epiphyses (HP:0003071)4.35930781
30Abnormality of the umbilical cord (HP:0010881)4.34261786
31Abnormality of the epiphysis of the femoral head (HP:0010574)4.32262660
32Coronal craniosynostosis (HP:0004440)4.15962232
33Mild short stature (HP:0003502)4.04713638
34Premature rupture of membranes (HP:0001788)4.02171306
35Neonatal short-limb short stature (HP:0008921)4.01679355
36Abnormality of the femoral head (HP:0003368)3.99641046
37Irregular vertebral endplates (HP:0003301)3.97080634
38Short femoral neck (HP:0100864)3.96326998
39Osteoarthritis (HP:0002758)3.84171857
40Metaphyseal irregularity (HP:0003025)3.72929088
41Myelomeningocele (HP:0002475)3.70084857
42Enlarged epiphyses (HP:0010580)3.66447637
43Double outlet right ventricle (HP:0001719)3.63381425
44Congenital malformation of the right heart (HP:0011723)3.63381425
45Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.61867865
46Coxa vara (HP:0002812)3.56385814
47Abnormality of oral frenula (HP:0000190)3.42379568
48Short tibia (HP:0005736)3.36173640
49Cortical dysplasia (HP:0002539)3.34545246
50Abnormality of the pubic bones (HP:0003172)3.32821027
51Protuberant abdomen (HP:0001538)3.31870603
52Abnormality of carpal bone ossification (HP:0006257)3.25744726
53Gonadotropin excess (HP:0000837)3.19577824
54Adrenal hypoplasia (HP:0000835)3.17471874
55Aplasia/Hypoplasia of the tibia (HP:0005772)3.12429445
56Abnormality of the phalanges of the 2nd finger (HP:0009541)3.07020404
57Abnormal vertebral ossification (HP:0100569)3.05538013
58Ureteral duplication (HP:0000073)3.00184178
59Waddling gait (HP:0002515)2.99584592
60Abnormalities of placenta or umbilical cord (HP:0001194)2.99370607
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.98343417
62Platyspondyly (HP:0000926)2.93923021
63Thoracolumbar scoliosis (HP:0002944)2.92503718
64Abnormality of incisor morphology (HP:0011063)2.91037492
65Abnormality of the proximal phalanges of the hand (HP:0009834)2.89769924
66Absent frontal sinuses (HP:0002688)2.88313300
67Ovoid vertebral bodies (HP:0003300)2.87270877
68Delayed CNS myelination (HP:0002188)2.86624252
69Meckel diverticulum (HP:0002245)2.86396440
70Missing ribs (HP:0000921)2.85932721
71Aplasia/hypoplasia of the femur (HP:0005613)2.80595083
72Barrel-shaped chest (HP:0001552)2.79668031
73Abnormal lung lobation (HP:0002101)2.75993640
74Limited elbow extension (HP:0001377)2.75422566
75Stillbirth (HP:0003826)2.74556120
76Thin ribs (HP:0000883)2.73138542
77Abnormality of the ileum (HP:0001549)2.70103464
78Cervical subluxation (HP:0003308)2.65891331
79Aplasia/hypoplasia of the humerus (HP:0006507)2.65116381
80Short humerus (HP:0005792)2.63691959
81Abnormality of chromosome stability (HP:0003220)2.63599169
82Vertebral clefting (HP:0008428)2.62920670
83Embryonal renal neoplasm (HP:0011794)2.61573318
84Deviation of the thumb (HP:0009603)2.61320748
85Abnormal hand bone ossification (HP:0010660)2.60665757
86Beaking of vertebral bodies (HP:0004568)2.57541968
87Long clavicles (HP:0000890)2.56419112
88Short middle phalanx of the 5th finger (HP:0004220)2.54482389
89Fibular hypoplasia (HP:0003038)2.53767194
90Proximal placement of thumb (HP:0009623)2.52450508
91Chromosomal breakage induced by crosslinking agents (HP:0003221)2.51626544
92Abnormal ossification of hand bones (HP:0005921)2.50423059
93Abnormality of the vitreous humor (HP:0004327)2.47430537
94Methylmalonic acidemia (HP:0002912)2.43447978
95Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.41489756
96Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.41109761
97Bell-shaped thorax (HP:0001591)2.40854714
98Limited hip movement (HP:0008800)2.37668234
99Exostoses (HP:0100777)2.37544154
100Lumbar hyperlordosis (HP:0002938)2.36255247
101Soft skin (HP:0000977)2.35848797
102Glossoptosis (HP:0000162)2.34310883
103Carpal bone hypoplasia (HP:0001498)2.33372788
104Vertebral hypoplasia (HP:0008417)2.32706851
105Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.32706851
106Hypoplasia of the capital femoral epiphysis (HP:0003090)2.27974685
107Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.26535856
108Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.25380761
109Short hallux (HP:0010109)2.25312744
110Abnormality of the lumbar spine (HP:0100712)2.25091661
111Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.22165087
112Abnormal ventriculo-arterial connection (HP:0011563)2.21667224
113Transposition of the great arteries (HP:0001669)2.21667224
114Abnormal connection of the cardiac segments (HP:0011545)2.21667224
115Hypoplasia of the odontoid process (HP:0003311)2.20291271
116Hip contracture (HP:0003273)2.17464052
117Micromelia (HP:0002983)2.16831110
118Peritonitis (HP:0002586)2.16637126
119Hepatoblastoma (HP:0002884)2.15458234
120Congenital, generalized hypertrichosis (HP:0004540)2.14138574
121Shawl scrotum (HP:0000049)2.12787020
122Septo-optic dysplasia (HP:0100842)2.12295585
123Spinal cord compression (HP:0002176)2.11608671
124Hypoplastic ilia (HP:0000946)2.10938659
125Hypoplastic pelvis (HP:0008839)2.10884413
126Testicular neoplasm (HP:0010788)2.10605265
127Small intestinal stenosis (HP:0012848)2.09539729
128Duodenal stenosis (HP:0100867)2.09539729
129Abnormality of the acetabulum (HP:0003170)2.08873584
130Broad phalanx (HP:0006009)2.08068027
131Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07265031
132Short middle phalanx of finger (HP:0005819)2.06544436
133Disproportionate short-trunk short stature (HP:0003521)2.06370550
134Abdominal situs inversus (HP:0003363)2.04649718
135Abnormality of abdominal situs (HP:0011620)2.04649718
136Abnormality of the 2nd finger (HP:0004100)2.04321698
137Bifid tongue (HP:0010297)2.03270894
138Mesomelia (HP:0003027)2.02994247
139Volvulus (HP:0002580)2.02547089
140Duplicated collecting system (HP:0000081)2.02417719
141Abnormality of the duodenum (HP:0002246)2.01870845
142Abnormality of the phalanges of the 5th finger (HP:0004213)2.00570526
143Abnormality of the preputium (HP:0100587)1.99507571
144Flat face (HP:0012368)1.99367566
145Facial diplegia (HP:0001349)1.97969122
146Patent foramen ovale (HP:0001655)1.97908343
147Preauricular pit (HP:0004467)1.97663390
148Periauricular skin pits (HP:0100277)1.97663390
149Anal stenosis (HP:0002025)1.97578456
150Arteriovenous malformation (HP:0100026)1.95371195
151Aplasia/Hypoplasia of the hallux (HP:0008362)1.95364241
152Radial bowing (HP:0002986)1.94697990
153Infantile muscular hypotonia (HP:0008947)1.94571558
154Chromsome breakage (HP:0040012)1.93589394
155Downturned corners of mouth (HP:0002714)1.93208175
156Broad long bones (HP:0005622)1.92977646
157Relative macrocephaly (HP:0004482)1.92693853
158Enlarged kidneys (HP:0000105)1.91568098
159Ulnar bowing (HP:0003031)1.87458117
160Triphalangeal thumb (HP:0001199)1.87220959
161Clubbing of toes (HP:0100760)1.86582227
162Dyschromatopsia (HP:0007641)1.85971376
163Oligohydramnios (HP:0001562)1.85239734
164Aortic dissection (HP:0002647)1.84836917
165Abnormality of the frontal sinuses (HP:0002687)1.83366137
166Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.83112770
167Abnormality of the septum pellucidum (HP:0007375)1.82978040
168Abnormal auditory evoked potentials (HP:0006958)1.82110129
169Pulmonary artery stenosis (HP:0004415)1.81095142
170Choroideremia (HP:0001139)1.80879651
171Abnormality of the odontoid process (HP:0003310)1.80778647
172Anophthalmia (HP:0000528)1.80365058
173Aplasia/Hypoplasia of the scapulae (HP:0006713)1.79637016
174Hypoplastic scapulae (HP:0000882)1.79637016
175Absent septum pellucidum (HP:0001331)1.79468380
176Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.78802842
177Genu valgum (HP:0002857)1.77084454
178Increased number of teeth (HP:0011069)1.76665977
179Abnormality of the pons (HP:0007361)1.75851234
180Mixed hearing impairment (HP:0000410)1.75713388
181Coxa valga (HP:0002673)1.75040021
182Neoplasm of the adrenal cortex (HP:0100641)1.74574473
183Rhizomelia (HP:0008905)1.74488580
184Microglossia (HP:0000171)1.74238011
185Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.72726397
186Short 1st metacarpal (HP:0010034)1.72726397
187Postnatal microcephaly (HP:0005484)1.72349135
188Hypoalphalipoproteinemia (HP:0003233)1.71943175

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K37.06737625
2STK106.67991544
3DDR26.19755457
4STK38L6.10129667
5STK245.92299364
6NME14.93997281
7WEE14.88577053
8LRRK23.72441188
9PRKG23.33856789
10TNIK3.26657498
11TRIM283.13103592
12PLK42.98415609
13MST42.88376333
14MAP3K82.62886187
15ACVR1B2.61070893
16ERBB32.21287607
17BMPR1B2.15044124
18PLK22.03723321
19DMPK1.98343225
20ROCK21.97541505
21TIE11.90031775
22STK31.79510238
23MUSK1.69460062
24LATS11.69375953
25DYRK1A1.64521034
26NEK11.62851216
27NUAK11.57796092
28MKNK21.56155501
29YES11.47979692
30TAF11.46982120
31EIF2AK31.41147580
32MAP3K101.34906078
33PNCK1.34472165
34TTK1.26468854
35PRKD31.26055183
36TAOK11.25543226
37PIK3CA1.25310315
38MAP3K121.17119065
39MAPK121.14301834
40NEK61.10683252
41BCR1.07706952
42MAPK71.00929318
43KDR0.99793084
44LIMK10.98692869
45MAPK130.98238067
46NEK20.96751192
47CAMKK20.96121645
48MKNK10.95500408
49EIF2AK10.90048125
50RAF10.89808247
51ROCK10.88666750
52MATK0.85835543
53EPHA20.84747480
54PDK20.82018730
55BRSK10.80207400
56TRPM70.79927943
57MAPK40.75861913
58PIM20.75102747
59GSK3A0.74476037
60LATS20.71809139
61WNK40.69485550
62KSR10.69288247
63ILK0.68262162
64TESK10.68236250
65BRAF0.68175498
66SRPK10.63839337
67NME20.63519389
68PLK30.62880431
69EPHA40.60982692
70SIK10.60493304
71BUB10.59255692
72SIK30.59059754
73DYRK30.58094013
74ERBB20.57891774
75MINK10.57812837
76VRK10.57689760
77MET0.57642611
78CASK0.54344390
79PLK10.53809594
80MAP2K30.51030152
81TAOK20.50278865
82ZAK0.49564324
83MARK30.45972909
84MAP3K40.45203662
85PRKAA20.43059679
86BMPR20.42367621
87STK390.42002250
88IRAK20.41461819
89PRKG10.40312868
90PIM10.39059270
91MAP3K90.39007909
92PRKACG0.38094654
93NLK0.37538734
94CDC70.37078920
95FGFR30.36561632
96EPHB20.34543094
97MAP3K110.33134106
98TGFBR20.31887119
99BRSK20.30848943
100TSSK60.29466329
101MAP3K50.28787868
102MAP3K60.28208600
103RPS6KB10.28108443
104MELK0.27328238
105PBK0.26229757
106PTK2B0.25981921
107CAMKK10.25375352
108PTK20.25178928
109MAPK100.25142216
110CSNK1A1L0.24645998
111SGK10.23337980
112PRKCH0.23030403
113FLT30.22291893
114SGK30.22181595
115PRKCD0.21406525
116CCNB10.20841179
117PRKCI0.20582052
118GRK50.19971560
119CDK70.19753907
120MAP2K70.19441905
121SGK20.19145184
122MYLK0.18810686
123FER0.18707273
124EIF2AK20.18558667
125ABL10.18387619
126AURKB0.18311779
127BRD40.18301237
128MAPK30.17781396
129PRKACA0.17404800
130IGF1R0.17370649
131PKN20.16427438
132FGFR10.15662840
133MOS0.14930217
134PHKG20.14929132
135PHKG10.14929132
136STK40.14202434
137CHEK10.13369270
138PDK10.13208566
139ABL20.12660347
140CDK50.12329899
141SGK2230.12014700
142SGK4940.12014700
143MAPK10.11902992
144PAK40.11769008
145CSK0.11617090
146MAP4K20.11395849
147ADRBK10.11333462
148PRKCG0.11306070
149CSNK1G10.11165974
150CAMK2D0.10918037
151PRKCQ0.10400518
152INSR0.10207011
153PRKCA0.10145131
154TGFBR10.10128784
155MAP3K140.10063317
156ERBB40.09711107
157TEC0.09686216
158PRKD10.09682312
159RET0.08807466
160MAP2K10.08715552
161CDK60.07752706
162WNK30.07721913
163PRKCE0.07666169
164MAPK140.07653181
165SCYL20.07603678

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005327.79405740
2Protein digestion and absorption_Homo sapiens_hsa049745.90873947
3ECM-receptor interaction_Homo sapiens_hsa045125.74410993
4Propanoate metabolism_Homo sapiens_hsa006403.30360960
5Sphingolipid metabolism_Homo sapiens_hsa006003.14353616
6Steroid biosynthesis_Homo sapiens_hsa001003.03993948
7Proteasome_Homo sapiens_hsa030503.00191730
8Sulfur metabolism_Homo sapiens_hsa009202.95122210
9Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.61114052
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.36035150
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.28589872
12Non-homologous end-joining_Homo sapiens_hsa034502.11458134
13Olfactory transduction_Homo sapiens_hsa047402.02987007
14Focal adhesion_Homo sapiens_hsa045102.02402347
15Fanconi anemia pathway_Homo sapiens_hsa034602.01245518
16Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.99777869
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.94860985
18Basal transcription factors_Homo sapiens_hsa030221.89119490
19Cell cycle_Homo sapiens_hsa041101.85081504
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75125471
21Protein export_Homo sapiens_hsa030601.73686359
22Pyruvate metabolism_Homo sapiens_hsa006201.71480466
23Starch and sucrose metabolism_Homo sapiens_hsa005001.70760078
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.63912985
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.61581217
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.61318171
27PI3K-Akt signaling pathway_Homo sapiens_hsa041511.57344336
28TGF-beta signaling pathway_Homo sapiens_hsa043501.50527619
29RNA transport_Homo sapiens_hsa030131.45409761
30Malaria_Homo sapiens_hsa051441.43133495
31RNA degradation_Homo sapiens_hsa030181.41490870
32Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.30355583
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25917161
34Selenocompound metabolism_Homo sapiens_hsa004501.19649426
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.16713601
36Hedgehog signaling pathway_Homo sapiens_hsa043401.11334750
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10654929
38Other glycan degradation_Homo sapiens_hsa005111.08310582
39Mismatch repair_Homo sapiens_hsa034301.06641070
40Homologous recombination_Homo sapiens_hsa034401.05241360
41Ovarian steroidogenesis_Homo sapiens_hsa049131.04733945
42mRNA surveillance pathway_Homo sapiens_hsa030151.00399868
43SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99301928
44Arginine and proline metabolism_Homo sapiens_hsa003300.99135349
45Base excision repair_Homo sapiens_hsa034100.98494543
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98153543
47Vitamin B6 metabolism_Homo sapiens_hsa007500.97790408
48Proteoglycans in cancer_Homo sapiens_hsa052050.97711924
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97694570
50p53 signaling pathway_Homo sapiens_hsa041150.96762289
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96534261
52Hippo signaling pathway_Homo sapiens_hsa043900.96279548
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96102630
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94183558
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92556093
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91525061
57Basal cell carcinoma_Homo sapiens_hsa052170.90983159
58Oocyte meiosis_Homo sapiens_hsa041140.88768873
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87696969
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84065042
61Inositol phosphate metabolism_Homo sapiens_hsa005620.82316517
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79278481
63MicroRNAs in cancer_Homo sapiens_hsa052060.78881303
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.76382870
65Vibrio cholerae infection_Homo sapiens_hsa051100.76361920
66Long-term depression_Homo sapiens_hsa047300.71943119
67Fatty acid metabolism_Homo sapiens_hsa012120.70544969
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69830728
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67086569
70Collecting duct acid secretion_Homo sapiens_hsa049660.67041271
71Salivary secretion_Homo sapiens_hsa049700.64675675
72Phagosome_Homo sapiens_hsa041450.64579692
73Galactose metabolism_Homo sapiens_hsa000520.64255164
74Pathways in cancer_Homo sapiens_hsa052000.63577613
75Circadian entrainment_Homo sapiens_hsa047130.63174536
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60471939
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60181802
78Wnt signaling pathway_Homo sapiens_hsa043100.59406502
79Morphine addiction_Homo sapiens_hsa050320.59187519
80Colorectal cancer_Homo sapiens_hsa052100.56251454
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55892326
82Dilated cardiomyopathy_Homo sapiens_hsa054140.54426517
83Oxytocin signaling pathway_Homo sapiens_hsa049210.54034230
84Fatty acid elongation_Homo sapiens_hsa000620.53061849
85N-Glycan biosynthesis_Homo sapiens_hsa005100.52130689
86Glutathione metabolism_Homo sapiens_hsa004800.51968898
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50682577
88Gap junction_Homo sapiens_hsa045400.50150184
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48728133
90Melanogenesis_Homo sapiens_hsa049160.48319229
91Arachidonic acid metabolism_Homo sapiens_hsa005900.47562812
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47268703
93Peroxisome_Homo sapiens_hsa041460.45911573
94Thyroid hormone synthesis_Homo sapiens_hsa049180.45691167
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45508218
96RNA polymerase_Homo sapiens_hsa030200.44365487
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43967758
98Folate biosynthesis_Homo sapiens_hsa007900.42255755
99Amoebiasis_Homo sapiens_hsa051460.40570113
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38665700
101Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38420927
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38160855
103Nitrogen metabolism_Homo sapiens_hsa009100.37768053
104Cocaine addiction_Homo sapiens_hsa050300.35847966
105Amphetamine addiction_Homo sapiens_hsa050310.35568613
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34521370
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.34249484
108HIF-1 signaling pathway_Homo sapiens_hsa040660.34198237
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.33461713
110Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.33406847
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32835455
112cAMP signaling pathway_Homo sapiens_hsa040240.32524619
113Tight junction_Homo sapiens_hsa045300.31599558
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.31581123
115Circadian rhythm_Homo sapiens_hsa047100.31175730
116Butanoate metabolism_Homo sapiens_hsa006500.30871296
117Alcoholism_Homo sapiens_hsa050340.29846303
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29480986
119Insulin secretion_Homo sapiens_hsa049110.29324217
120Parkinsons disease_Homo sapiens_hsa050120.29123625
121Cholinergic synapse_Homo sapiens_hsa047250.28124561
122Spliceosome_Homo sapiens_hsa030400.27119015
123Dorso-ventral axis formation_Homo sapiens_hsa043200.26878842
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25921636
125Phototransduction_Homo sapiens_hsa047440.24035350
126Renal cell carcinoma_Homo sapiens_hsa052110.23942721
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23123809
128Legionellosis_Homo sapiens_hsa051340.22050087
129Serotonergic synapse_Homo sapiens_hsa047260.22042438
130Metabolic pathways_Homo sapiens_hsa011000.21621245
131Carbon metabolism_Homo sapiens_hsa012000.21477642
132Shigellosis_Homo sapiens_hsa051310.21414922
133Vitamin digestion and absorption_Homo sapiens_hsa049770.21267174
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21084684
135Thyroid cancer_Homo sapiens_hsa052160.20446401
136ErbB signaling pathway_Homo sapiens_hsa040120.20369797
137Lysine degradation_Homo sapiens_hsa003100.20265770
138Small cell lung cancer_Homo sapiens_hsa052220.20213783
139Axon guidance_Homo sapiens_hsa043600.19782971
140Bile secretion_Homo sapiens_hsa049760.19731425
141Glutamatergic synapse_Homo sapiens_hsa047240.18994255
142GABAergic synapse_Homo sapiens_hsa047270.18753656
143Purine metabolism_Homo sapiens_hsa002300.18432188
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18020190
145Adherens junction_Homo sapiens_hsa045200.17813727
146Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.16394836
147Rap1 signaling pathway_Homo sapiens_hsa040150.16192965
148Complement and coagulation cascades_Homo sapiens_hsa046100.16028380
149Platelet activation_Homo sapiens_hsa046110.15318299
150Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14742391
151Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.13651509
152One carbon pool by folate_Homo sapiens_hsa006700.12282097
153Hematopoietic cell lineage_Homo sapiens_hsa046400.12066689
154Glioma_Homo sapiens_hsa052140.11705299
155Glucagon signaling pathway_Homo sapiens_hsa049220.11568274
156Regulation of actin cytoskeleton_Homo sapiens_hsa048100.11403305
157Ras signaling pathway_Homo sapiens_hsa040140.10851236
158Central carbon metabolism in cancer_Homo sapiens_hsa052300.10716301
159Dopaminergic synapse_Homo sapiens_hsa047280.10595083

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »