HAPLN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.63586288
2synaptic vesicle docking involved in exocytosis (GO:0016081)7.14015334
3glutamate secretion (GO:0014047)6.73042135
4synaptic vesicle exocytosis (GO:0016079)6.20101730
5myelin maintenance (GO:0043217)6.18609584
6axon ensheathment (GO:0008366)6.00112469
7ensheathment of neurons (GO:0007272)6.00112469
8myelination (GO:0042552)5.96826350
9regulation of synaptic vesicle exocytosis (GO:2000300)5.83510773
10long-chain fatty acid biosynthetic process (GO:0042759)5.77141534
11response to methylmercury (GO:0051597)5.63425785
12regulation of short-term neuronal synaptic plasticity (GO:0048172)5.51981685
13sodium ion export (GO:0071436)5.44846625
14membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.24093071
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.22098734
16neuronal ion channel clustering (GO:0045161)5.01535740
17L-amino acid import (GO:0043092)4.98716194
18regulation of synaptic vesicle transport (GO:1902803)4.95825580
19establishment of mitochondrion localization (GO:0051654)4.93554019
20neurotransmitter secretion (GO:0007269)4.93096927
21regulation of neuronal synaptic plasticity (GO:0048168)4.90411255
22negative regulation of protein localization to cell surface (GO:2000009)4.76471638
23negative regulation of neurotransmitter transport (GO:0051589)4.63761153
24locomotory exploration behavior (GO:0035641)4.62962511
25potassium ion homeostasis (GO:0055075)4.59743312
26amyloid precursor protein metabolic process (GO:0042982)4.54477725
27postsynaptic membrane organization (GO:0001941)4.41357323
28glycine transport (GO:0015816)4.40428227
29regulation of lipoprotein metabolic process (GO:0050746)4.32848207
30cholesterol biosynthetic process (GO:0006695)4.28608050
31negative regulation of synaptic transmission, GABAergic (GO:0032229)4.26886043
32creatine metabolic process (GO:0006600)4.24149130
33regulation of collateral sprouting (GO:0048670)4.23492387
34positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.20742460
35cerebellar granule cell differentiation (GO:0021707)4.20622908
36regulation of long-term neuronal synaptic plasticity (GO:0048169)4.14420717
37positive regulation of oligodendrocyte differentiation (GO:0048714)4.12373694
38long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.12134626
39neurotransmitter transport (GO:0006836)4.07808527
40positive regulation of synapse maturation (GO:0090129)4.06532643
41vocalization behavior (GO:0071625)4.04185623
42cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.01987855
43long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.01616332
44regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.00923243
45ionotropic glutamate receptor signaling pathway (GO:0035235)3.98506269
46sterol biosynthetic process (GO:0016126)3.85781893
47exploration behavior (GO:0035640)3.85120775
48neurotransmitter uptake (GO:0001504)3.83967621
49acidic amino acid transport (GO:0015800)3.80634932
50negative regulation of neurotransmitter secretion (GO:0046929)3.80040842
51regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.79475305
52regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.74833987
53regulation of synaptic plasticity (GO:0048167)3.74427856
54regulation of neurotransmitter levels (GO:0001505)3.73538830
55positive regulation of dendritic spine development (GO:0060999)3.69870519
56oligodendrocyte differentiation (GO:0048709)3.69128401
57neuromuscular process controlling balance (GO:0050885)3.68390191
58amino acid import (GO:0043090)3.67305435
59import into cell (GO:0098657)3.66092634
60regulation of glutamate receptor signaling pathway (GO:1900449)3.65968903
61membrane tubulation (GO:0097320)3.64365403
62eye photoreceptor cell differentiation (GO:0001754)3.59607320
63photoreceptor cell differentiation (GO:0046530)3.59607320
64regulation of neurotransmitter secretion (GO:0046928)3.58888117
65fatty-acyl-CoA biosynthetic process (GO:0046949)3.57181392
66adult walking behavior (GO:0007628)3.56684287
67regulation of synapse structural plasticity (GO:0051823)3.55915039
68response to lipoprotein particle (GO:0055094)3.53954078
69regulation of voltage-gated calcium channel activity (GO:1901385)3.53720305
70positive regulation of membrane potential (GO:0045838)3.53213919
71synaptic transmission, glutamatergic (GO:0035249)3.50219593
72regulation of ARF protein signal transduction (GO:0032012)3.50089515
73cell communication by electrical coupling (GO:0010644)3.46319975
74regulation of excitatory postsynaptic membrane potential (GO:0060079)3.46209522
75cellular sodium ion homeostasis (GO:0006883)3.44430588
76neurotransmitter-gated ion channel clustering (GO:0072578)3.44412453
77fatty-acyl-CoA metabolic process (GO:0035337)3.43753512
78L-glutamate transport (GO:0015813)3.41911294
79long-term synaptic potentiation (GO:0060291)3.40745563
80regulation of neurotransmitter transport (GO:0051588)3.39771360
81cerebellar Purkinje cell differentiation (GO:0021702)3.36620110
82isoprenoid biosynthetic process (GO:0008299)3.36417747
83peptidyl-tyrosine autophosphorylation (GO:0038083)3.33970686
84presynaptic membrane organization (GO:0097090)3.33153151
85very long-chain fatty acid metabolic process (GO:0000038)3.32742327
86synaptic vesicle endocytosis (GO:0048488)3.32373753
87apical protein localization (GO:0045176)3.26391145
88glycerophospholipid catabolic process (GO:0046475)3.25820306
89neuron remodeling (GO:0016322)3.25806237
90regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.25802092
91regulation of dendritic spine morphogenesis (GO:0061001)3.25293659
92astrocyte development (GO:0014002)3.22245666
93neuronal action potential propagation (GO:0019227)3.21607697
94positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.21023455
95asymmetric protein localization (GO:0008105)3.20577446
96gamma-aminobutyric acid transport (GO:0015812)3.20555794
97regulation of dendritic spine development (GO:0060998)3.19391943
98substantia nigra development (GO:0021762)3.18297584
99protein localization to synapse (GO:0035418)3.16047981
100regulation of synapse maturation (GO:0090128)3.15348502
101regulation of postsynaptic membrane potential (GO:0060078)3.14544286
102neuron-neuron synaptic transmission (GO:0007270)3.11894525
103long-term memory (GO:0007616)3.10313882
104glutamate receptor signaling pathway (GO:0007215)3.09461657
105protein palmitoylation (GO:0018345)3.09181839
106transmission of nerve impulse (GO:0019226)3.09181387
107synaptic vesicle maturation (GO:0016188)3.07368181
108regulation of synaptic transmission (GO:0050804)3.07327659
109gamma-aminobutyric acid signaling pathway (GO:0007214)3.07073870
110negative regulation of dendrite morphogenesis (GO:0050774)3.05828693
111axon development (GO:0061564)3.05772135
112substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.03585029
113substrate-independent telencephalic tangential migration (GO:0021826)3.03585029
114positive regulation of neurotransmitter transport (GO:0051590)3.03207372
115positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.01506172
116auditory behavior (GO:0031223)3.01315296
117regulation of vesicle fusion (GO:0031338)2.97018878
118detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.95651456
119detection of temperature stimulus involved in sensory perception (GO:0050961)2.95651456
120positive regulation of neurotransmitter secretion (GO:0001956)2.95179948
121positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.93165713
122iron coordination entity transport (GO:1901678)2.92875649
123cerebellar Purkinje cell layer development (GO:0021680)2.92253379
124cytoskeletal anchoring at plasma membrane (GO:0007016)2.91874052
125neural nucleus development (GO:0048857)2.91711155
126positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.90605564
127detection of calcium ion (GO:0005513)2.87837078
128magnesium ion transport (GO:0015693)2.87756958
129regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.87678936
130negative regulation of execution phase of apoptosis (GO:1900118)2.85714672
131negative regulation of macroautophagy (GO:0016242)2.83113130
132acyl-CoA biosynthetic process (GO:0071616)2.81373151
133thioester biosynthetic process (GO:0035384)2.81373151
134response to redox state (GO:0051775)2.81257712
135negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.80779737
136nerve growth factor signaling pathway (GO:0038180)2.79328689
137negative regulation of axonogenesis (GO:0050771)2.78317516
138heme transport (GO:0015886)2.76911265
139positive regulation of glial cell differentiation (GO:0045687)2.76620915
140cerebral cortex radially oriented cell migration (GO:0021799)2.75308028
141limb bud formation (GO:0060174)2.75094099
142astrocyte differentiation (GO:0048708)2.74459775
143enteric nervous system development (GO:0048484)2.73666256
144potassium ion import (GO:0010107)2.72658812
145positive regulation of gliogenesis (GO:0014015)2.72203332
146glycosylceramide metabolic process (GO:0006677)2.72161561
147peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.69075511
148amyloid precursor protein catabolic process (GO:0042987)2.65925352
149peripheral nervous system axon ensheathment (GO:0032292)2.63473987
150myelination in peripheral nervous system (GO:0022011)2.63473987
151regulation of catecholamine metabolic process (GO:0042069)2.63281805
152regulation of dopamine metabolic process (GO:0042053)2.63281805
153peptidyl-cysteine modification (GO:0018198)2.61665623
154regulation of autophagic vacuole assembly (GO:2000785)2.61288693
155mechanosensory behavior (GO:0007638)2.59898843
156GPI anchor biosynthetic process (GO:0006506)2.59240012
157neuron recognition (GO:0008038)2.59045071
158tissue regeneration (GO:0042246)2.58526457
159organ growth (GO:0035265)2.57025088
160regulation of vacuole organization (GO:0044088)2.55058142
161GPI anchor metabolic process (GO:0006505)2.53418928
162Golgi to endosome transport (GO:0006895)2.52191836
163dendritic spine morphogenesis (GO:0060997)2.50658041
164negative regulation of inclusion body assembly (GO:0090084)2.50125742
165presynaptic membrane assembly (GO:0097105)2.49914602
166peripheral nervous system development (GO:0007422)2.49838279
167regulation of neurotransmitter uptake (GO:0051580)2.48503936
168neuromuscular process controlling posture (GO:0050884)2.48369690
169cellular potassium ion homeostasis (GO:0030007)2.47436932
170negative regulation of chemokine production (GO:0032682)2.46234974
171neuron cell-cell adhesion (GO:0007158)2.46208562
172adult locomotory behavior (GO:0008344)2.45983006
173axon ensheathment in central nervous system (GO:0032291)12.6781772
174central nervous system myelination (GO:0022010)12.6781772

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.53040783
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.16416226
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.95758941
4GBX2_23144817_ChIP-Seq_PC3_Human2.74659125
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.61593783
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61092651
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.58023096
8SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.45783697
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.37193241
10AR_21572438_ChIP-Seq_LNCaP_Human2.28977326
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24479245
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21771162
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.19305861
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.19305861
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13448673
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11563632
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07829703
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.01797942
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97281282
20* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.96422161
21OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.95938718
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.94866375
23RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.92691507
24* EZH2_27294783_Chip-Seq_ESCs_Mouse1.91366864
25* KDM2B_26808549_Chip-Seq_K562_Human1.90707492
26* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.83133312
27RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.83112746
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82496308
29DROSHA_22980978_ChIP-Seq_HELA_Human1.76173073
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76035603
31* RNF2_27304074_Chip-Seq_ESCs_Mouse1.71655980
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71069288
33TAF15_26573619_Chip-Seq_HEK293_Human1.66956107
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66104362
35RARB_27405468_Chip-Seq_BRAIN_Mouse1.65976150
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61488243
37EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.59628647
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57823030
39* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56629850
40ZFP281_27345836_Chip-Seq_ESCs_Mouse1.50651766
41LXR_22292898_ChIP-Seq_THP-1_Human1.46813997
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43339732
43CTCF_27219007_Chip-Seq_Bcells_Human1.41238140
44* REST_21632747_ChIP-Seq_MESCs_Mouse1.40676813
45TET1_21490601_ChIP-Seq_MESCs_Mouse1.39631376
46OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.39323891
47ER_23166858_ChIP-Seq_MCF-7_Human1.37870300
48STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.37430696
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.35967167
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35808134
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.34858956
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.34636319
53TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33853820
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.32801562
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32393073
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32087302
57VDR_22108803_ChIP-Seq_LS180_Human1.31932466
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29094038
59SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26981077
60LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24057316
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.23604879
62ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22104488
63OCT4_19829295_ChIP-Seq_ESCs_Human1.21624577
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20917634
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18244478
66P300_19829295_ChIP-Seq_ESCs_Human1.17925584
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16857226
68WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15900705
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15423949
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15216065
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14686309
72PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.14124981
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.12785585
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12783608
75NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12783608
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12014888
77STAT3_23295773_ChIP-Seq_U87_Human1.11205446
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10696331
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10400169
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09219737
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08510895
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.08252307
83SMC4_20622854_ChIP-Seq_HELA_Human1.07381427
84* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05961503
85EP300_21415370_ChIP-Seq_HL-1_Mouse1.05537508
86GATA1_26923725_Chip-Seq_HPCs_Mouse1.04315784
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03876229
88KDM2B_26808549_Chip-Seq_DND41_Human1.03684602
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02435075
90SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01611983
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.00160645
92SMAD4_21799915_ChIP-Seq_A2780_Human0.99483644
93SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99439512
94EOMES_21245162_ChIP-Seq_HESCs_Human0.98680461
95* PRDM14_20953172_ChIP-Seq_ESCs_Human0.98668472
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98542000
97* AR_19668381_ChIP-Seq_PC3_Human0.98257345
98ERG_21242973_ChIP-ChIP_JURKAT_Human0.97770417
99POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97433383
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97138831
101P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96785158
102GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96764517
103TAL1_26923725_Chip-Seq_HPCs_Mouse0.96316292
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96255902
105IGF1R_20145208_ChIP-Seq_DFB_Human0.96176477
106DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96159795
107CMYC_18555785_Chip-Seq_ESCs_Mouse0.95401850
108SMAD4_21741376_ChIP-Seq_EPCs_Human0.94881811
109* DPY_21335234_ChIP-Seq_ESCs_Mouse0.94150142
110NANOG_19829295_ChIP-Seq_ESCs_Human0.93174709
111SOX2_19829295_ChIP-Seq_ESCs_Human0.93174709
112* RING1B_27294783_Chip-Seq_ESCs_Mouse0.93056337
113TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92982710
114EGR1_19032775_ChIP-ChIP_M12_Human0.92897505
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92265647
116TP53_16413492_ChIP-PET_HCT116_Human0.91945189
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91896872
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91882984
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91558861
120CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91536109
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91139353
122TCF4_23295773_ChIP-Seq_U87_Human0.91027985
123NANOG_18555785_Chip-Seq_ESCs_Mouse0.90565371
124HTT_18923047_ChIP-ChIP_STHdh_Human0.89690009
125SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.89565059
126* RING1B_27294783_Chip-Seq_NPCs_Mouse0.89234401
127SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89200586
128TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86781898
129SMAD4_21741376_ChIP-Seq_ESCs_Human0.86672651
130ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86619726
131P68_20966046_ChIP-Seq_HELA_Human0.86559052
132EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86428925
133SOX2_21211035_ChIP-Seq_LN229_Gbm0.86006099
134GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.85148554
135* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84705309
136AHR_22903824_ChIP-Seq_MCF-7_Human0.84490834
137* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84234933
138* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.83746555
139* KDM2B_26808549_Chip-Seq_JURKAT_Human0.83721808
140P300_18555785_Chip-Seq_ESCs_Mouse0.83645260
141KLF4_19829295_ChIP-Seq_ESCs_Human0.83464270
142RNF2_27304074_Chip-Seq_NSC_Mouse0.83437053
143CREB1_26743006_Chip-Seq_LNCaP_Human0.83065747
144* MYC_19915707_ChIP-ChIP_AK7_Human0.80783824
145TP53_23651856_ChIP-Seq_MEFs_Mouse0.80594738
146DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.79347444
147UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.78586325
148* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.78522657
149MITF_21258399_ChIP-Seq_MELANOMA_Human0.78176948
150YAP1_20516196_ChIP-Seq_MESCs_Mouse0.77821292
151RUNX1_26923725_Chip-Seq_HPCs_Mouse0.75660922
152SMAD3_21741376_ChIP-Seq_ESCs_Human0.74663469
153CTCF_20526341_ChIP-Seq_ESCs_Human0.73912219
154SRY_22984422_ChIP-ChIP_TESTIS_Rat0.71569664
155SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.71181632

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.14183411
2MP0003880_abnormal_central_pattern4.29423441
3MP0003950_abnormal_plasma_membrane3.59939798
4MP0004270_analgesia3.18319517
5MP0003690_abnormal_glial_cell3.06321641
6MP0003329_amyloid_beta_deposits2.91556326
7MP0002272_abnormal_nervous_system2.82738352
8MP0001529_abnormal_vocalization2.79310974
9MP0005423_abnormal_somatic_nervous2.71528235
10MP0004859_abnormal_synaptic_plasticity2.68480109
11MP0001486_abnormal_startle_reflex2.63769543
12MP0004885_abnormal_endolymph2.61060767
13MP0005171_absent_coat_pigmentation2.58152850
14MP0004142_abnormal_muscle_tone2.55974768
15MP0002064_seizures2.52162201
16MP0004742_abnormal_vestibular_system2.26056533
17MP0001905_abnormal_dopamine_level2.23134945
18MP0003634_abnormal_glial_cell2.21369340
19MP0003635_abnormal_synaptic_transmissio2.20507870
20MP0005410_abnormal_fertilization2.10721990
21MP0004043_abnormal_pH_regulation2.08320094
22MP0009745_abnormal_behavioral_response2.07697772
23MP0009046_muscle_twitch2.01706558
24MP0002822_catalepsy1.92012349
25MP0000778_abnormal_nervous_system1.89362411
26MP0009780_abnormal_chondrocyte_physiolo1.87754366
27MP0003879_abnormal_hair_cell1.87418395
28MP0002734_abnormal_mechanical_nocicepti1.81343856
29MP0008569_lethality_at_weaning1.80688378
30MP0002229_neurodegeneration1.80126623
31MP0001485_abnormal_pinna_reflex1.78658369
32MP0005409_darkened_coat_color1.78132113
33MP0002063_abnormal_learning/memory/cond1.77854849
34MP0003632_abnormal_nervous_system1.77407675
35MP0003136_yellow_coat_color1.76653581
36* MP0003631_nervous_system_phenotype1.68985537
37* MP0003633_abnormal_nervous_system1.67537130
38MP0002572_abnormal_emotion/affect_behav1.67115646
39MP0001970_abnormal_pain_threshold1.59952723
40MP0010678_abnormal_skin_adnexa1.59026040
41MP0008260_abnormal_autophagy1.57456190
42MP0000604_amyloidosis1.52948361
43MP0003787_abnormal_imprinting1.48361229
44MP0000955_abnormal_spinal_cord1.48326262
45MP0001984_abnormal_olfaction1.47291532
46MP0003195_calcinosis1.42568177
47MP0005167_abnormal_blood-brain_barrier1.38574906
48MP0002066_abnormal_motor_capabilities/c1.35470531
49MP0005623_abnormal_meninges_morphology1.34749340
50MP0002067_abnormal_sensory_capabilities1.34157556
51MP0004381_abnormal_hair_follicle1.32187335
52MP0001440_abnormal_grooming_behavior1.30208495
53MP0000462_abnormal_digestive_system1.29979756
54* MP0002882_abnormal_neuron_morphology1.28209335
55MP0000747_muscle_weakness1.26648839
56MP0002733_abnormal_thermal_nociception1.22002548
57MP0001177_atelectasis1.20349673
58MP0004134_abnormal_chest_morphology1.19203432
59MP0000383_abnormal_hair_follicle1.18992788
60MP0001968_abnormal_touch/_nociception1.16887148
61MP0009840_abnormal_foam_cell1.16323458
62MP0005386_behavior/neurological_phenoty1.11018595
63MP0004924_abnormal_behavior1.11018595
64MP0003123_paternal_imprinting1.07738593
65MP0003806_abnormal_nucleotide_metabolis1.05512572
66MP0006276_abnormal_autonomic_nervous1.03811146
67MP0001963_abnormal_hearing_physiology1.02917321
68MP0005058_abnormal_lysosome_morphology1.02271725
69* MP0005551_abnormal_eye_electrophysiolog1.01401599
70MP0001299_abnormal_eye_distance/0.97578874
71MP0008874_decreased_physiological_sensi0.96713250
72MP0003656_abnormal_erythrocyte_physiolo0.95919384
73MP0002752_abnormal_somatic_nervous0.95864438
74MP0000003_abnormal_adipose_tissue0.95200490
75MP0001501_abnormal_sleep_pattern0.94752160
76MP0004145_abnormal_muscle_electrophysio0.94509317
77MP0005451_abnormal_body_composition0.91767358
78MP0000566_synostosis0.90423788
79MP0003075_altered_response_to0.89195709
80MP0004811_abnormal_neuron_physiology0.85496800
81MP0002736_abnormal_nociception_after0.83879377
82MP0003122_maternal_imprinting0.83853013
83MP0000579_abnormal_nail_morphology0.83778929
84MP0002557_abnormal_social/conspecific_i0.83388124
85MP0004036_abnormal_muscle_relaxation0.82882551
86MP0002152_abnormal_brain_morphology0.82219416
87MP0000647_abnormal_sebaceous_gland0.82204313
88MP0002735_abnormal_chemical_nociception0.80789992
89MP0005195_abnormal_posterior_eye0.79886839
90MP0001346_abnormal_lacrimal_gland0.78982225
91MP0001502_abnormal_circadian_rhythm0.78394411
92MP0004147_increased_porphyrin_level0.77021342
93MP0000749_muscle_degeneration0.75895309
94MP0002184_abnormal_innervation0.75254466
95MP0006082_CNS_inflammation0.73720052
96MP0001986_abnormal_taste_sensitivity0.71741964
97MP0005535_abnormal_body_temperature0.71205759
98MP0005646_abnormal_pituitary_gland0.70470894
99MP0002295_abnormal_pulmonary_circulatio0.70368433
100MP0005645_abnormal_hypothalamus_physiol0.70091165
101MP0000762_abnormal_tongue_morphology0.68279335
102MP0001851_eye_inflammation0.66750181
103MP0004858_abnormal_nervous_system0.66498892
104MP0002069_abnormal_eating/drinking_beha0.66432045
105MP0003137_abnormal_impulse_conducting0.65115334
106MP0002090_abnormal_vision0.64537752
107MP0002133_abnormal_respiratory_system0.62390143
108MP0005388_respiratory_system_phenotype0.62390143
109MP0000639_abnormal_adrenal_gland0.61595478
110MP0004130_abnormal_muscle_cell0.61464957
111MP0003938_abnormal_ear_development0.61315784
112MP0005166_decreased_susceptibility_to0.61030656
113MP0003172_abnormal_lysosome_physiology0.59962177
114MP0005253_abnormal_eye_physiology0.59841870
115MP0002909_abnormal_adrenal_gland0.57089758
116MP0000026_abnormal_inner_ear0.55471678
117MP0001943_abnormal_respiration0.55377804
118MP0002638_abnormal_pupillary_reflex0.55130749
119MP0009250_abnormal_appendicular_skeleto0.54510415
120MP0010769_abnormal_survival0.53310039
121MP0010768_mortality/aging0.49694725
122MP0010770_preweaning_lethality0.48698153
123MP0002082_postnatal_lethality0.48698153
124MP0001348_abnormal_lacrimal_gland0.48569589
125MP0002089_abnormal_postnatal_growth/wei0.46427201
126MP0003956_abnormal_body_size0.45779912
127MP0003283_abnormal_digestive_organ0.44842908
128MP0002873_normal_phenotype0.44468979
129MP0003861_abnormal_nervous_system0.43182949
130MP0001731_abnormal_postnatal_growth0.42698179

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)6.39688688
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.98791472
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.98791472
4Peripheral hypomyelination (HP:0007182)5.12511021
5Focal seizures (HP:0007359)4.86327121
6Diplopia (HP:0000651)4.83223663
7Abnormality of binocular vision (HP:0011514)4.83223663
8Cerebral hypomyelination (HP:0006808)4.81074644
9Cerebral inclusion bodies (HP:0100314)4.76462427
10Abnormality of the corticospinal tract (HP:0002492)4.57593660
11Supranuclear gaze palsy (HP:0000605)4.49398903
12Onion bulb formation (HP:0003383)4.46609579
13Ankle clonus (HP:0011448)4.21639679
14Febrile seizures (HP:0002373)4.16577289
15Termporal pattern (HP:0011008)4.12788931
16Insidious onset (HP:0003587)4.12788931
17Epileptic encephalopathy (HP:0200134)4.09931650
18Segmental peripheral demyelination/remyelination (HP:0003481)4.03955268
19Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.96519210
20Myokymia (HP:0002411)3.94291359
21Atonic seizures (HP:0010819)3.93360331
22Abnormal auditory evoked potentials (HP:0006958)3.86628923
23Parakeratosis (HP:0001036)3.75904465
24Visual hallucinations (HP:0002367)3.62105413
25Abnormal eating behavior (HP:0100738)3.51111761
26Dysmetria (HP:0001310)3.43507405
27Spastic gait (HP:0002064)3.40745797
28Alacrima (HP:0000522)3.40461898
29Retinal dysplasia (HP:0007973)3.33833246
30Intention tremor (HP:0002080)3.32405003
31Generalized tonic-clonic seizures (HP:0002069)3.29021270
32Slow saccadic eye movements (HP:0000514)3.26778426
33Leukodystrophy (HP:0002415)3.22446204
34Axonal loss (HP:0003447)3.21551862
35CNS hypomyelination (HP:0003429)3.20378648
36Scanning speech (HP:0002168)3.13882327
37Urinary bladder sphincter dysfunction (HP:0002839)3.11394265
38Sensory axonal neuropathy (HP:0003390)3.11296054
39Postural instability (HP:0002172)3.09457588
40Action tremor (HP:0002345)3.06632904
41Delusions (HP:0000746)3.05120829
42Obstructive sleep apnea (HP:0002870)3.03511768
43Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.92025491
44Progressive cerebellar ataxia (HP:0002073)2.90731063
45Tetraplegia (HP:0002445)2.88351983
46Morphological abnormality of the inner ear (HP:0011390)2.85086300
47Mutism (HP:0002300)2.83953926
48Hemiplegia (HP:0002301)2.82663491
49Annular pancreas (HP:0001734)2.82384298
50Truncal ataxia (HP:0002078)2.81637841
51Spastic tetraparesis (HP:0001285)2.76070758
52Absence seizures (HP:0002121)2.72429675
53Insomnia (HP:0100785)2.71688078
54Papilledema (HP:0001085)2.71551737
55Decreased lacrimation (HP:0000633)2.66895046
56Pheochromocytoma (HP:0002666)2.65815225
57Impaired vibration sensation in the lower limbs (HP:0002166)2.62344977
58Depression (HP:0000716)2.61986928
59Dialeptic seizures (HP:0011146)2.61611996
60Anteriorly placed anus (HP:0001545)2.57540456
61Foot dorsiflexor weakness (HP:0009027)2.56614866
62Akinesia (HP:0002304)2.53773820
63Diaphragmatic weakness (HP:0009113)2.53419530
64Urinary urgency (HP:0000012)2.51546102
65Aplasia involving bones of the upper limbs (HP:0009823)2.49703362
66Aplasia of the phalanges of the hand (HP:0009802)2.49703362
67Aplasia involving bones of the extremities (HP:0009825)2.49703362
68Clumsiness (HP:0002312)2.48571168
69Apathy (HP:0000741)2.48090671
70Focal dystonia (HP:0004373)2.47502742
71Absent septum pellucidum (HP:0001331)2.47301239
72Hypoplasia of the iris (HP:0007676)2.46814051
73Increased circulating renin level (HP:0000848)2.45510765
74Sleep apnea (HP:0010535)2.44247368
75Hemiparesis (HP:0001269)2.41822841
76Metabolic alkalosis (HP:0200114)2.39893312
77Spastic paraparesis (HP:0002313)2.38860742
78Cerebral hemorrhage (HP:0001342)2.38639767
79Clonus (HP:0002169)2.38113785
80Abnormality of the foot musculature (HP:0001436)2.37599058
81Bradykinesia (HP:0002067)2.37376177
82Hypoplastic pelvis (HP:0008839)2.36867809
83Focal motor seizures (HP:0011153)2.35127039
84Rapidly progressive (HP:0003678)2.35091685
85Craniofacial dystonia (HP:0012179)2.33686305
86Lower limb muscle weakness (HP:0007340)2.33244739
87Stridor (HP:0010307)2.31903637
88Limb dystonia (HP:0002451)2.27294032
89Poor speech (HP:0002465)2.26621147
90Megalencephaly (HP:0001355)2.26219948
91Status epilepticus (HP:0002133)2.25989375
92Abnormality of glycolysis (HP:0004366)2.25103377
93Increased serum pyruvate (HP:0003542)2.25103377
94Choreoathetosis (HP:0001266)2.24058840
95Diminished motivation (HP:0000745)2.23603012
96Split foot (HP:0001839)2.21244569
97Decreased motor nerve conduction velocity (HP:0003431)2.20179987
98Poor eye contact (HP:0000817)2.19610872
99Hammertoe (HP:0001765)2.18798644
100Neuroendocrine neoplasm (HP:0100634)2.18234618
101Peripheral demyelination (HP:0011096)2.17743785
102Neuronal loss in central nervous system (HP:0002529)2.15281638
103White forelock (HP:0002211)2.14792395
104Coronal craniosynostosis (HP:0004440)2.11667158
105Paraparesis (HP:0002385)2.09890637
106Hypokalemic alkalosis (HP:0001949)2.09089880
107Distal sensory impairment (HP:0002936)2.07416393
108Abnormality of the phalanges of the 2nd finger (HP:0009541)2.06348205
109Epileptiform EEG discharges (HP:0011182)2.05845087
110Bundle branch block (HP:0011710)2.05248944
111Patchy hypopigmentation of hair (HP:0011365)2.04644667
112Abnormality of the septum pellucidum (HP:0007375)2.03734343
113Difficulty running (HP:0009046)2.03650001
114Memory impairment (HP:0002354)2.02417998
115Congenital ichthyosiform erythroderma (HP:0007431)2.00236982
116Muscle fiber splitting (HP:0003555)2.00108334
117Bowel incontinence (HP:0002607)1.98220319
118Thickened helices (HP:0000391)1.96836367
119Abnormality of the middle phalanges of the toes (HP:0010183)1.94844808
120Partial duplication of thumb phalanx (HP:0009944)1.92772722
121Urinary incontinence (HP:0000020)1.92000053
122Turricephaly (HP:0000262)1.91897114
123Morphological abnormality of the pyramidal tract (HP:0002062)1.91486856
124Premature skin wrinkling (HP:0100678)1.91027034
125Slow progression (HP:0003677)1.89885324
126Abnormality of saccadic eye movements (HP:0000570)1.89717411
127Hyporeflexia of lower limbs (HP:0002600)1.88068086
128Abnormality of the periventricular white matter (HP:0002518)1.87628831
129Dysdiadochokinesis (HP:0002075)1.87002470
130Spastic paraplegia (HP:0001258)1.86829474
131Impaired social interactions (HP:0000735)1.86240864
132Abnormal social behavior (HP:0012433)1.86240864
133Esophageal atresia (HP:0002032)1.86194411
134Gowers sign (HP:0003391)1.85333624
135Impaired vibratory sensation (HP:0002495)1.84256598
136Abnormal large intestine physiology (HP:0012700)1.83772523
137Hypomagnesemia (HP:0002917)1.83688979
138Loss of speech (HP:0002371)1.83606589
139Hyperlipoproteinemia (HP:0010980)1.83443456
140Abnormality of cochlea (HP:0000375)1.83417236
141Abnormality of the lower motor neuron (HP:0002366)1.83105646
142Paraplegia (HP:0010550)1.82177162
143Lower limb amyotrophy (HP:0007210)1.82174803
144Abnormality of the salivary glands (HP:0010286)1.82025444
145Methylmalonic acidemia (HP:0002912)1.80749293
146Hypophosphatemic rickets (HP:0004912)1.80030340
147Torticollis (HP:0000473)1.79767353
148Anxiety (HP:0000739)1.79372132
149Rigidity (HP:0002063)1.78982389

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.56271407
2MAPKAPK54.21660843
3OXSR13.81410087
4EPHB13.77820690
5DAPK23.02920785
6PKN13.00227998
7PBK2.40703785
8FGFR22.34958221
9UHMK12.25514982
10CAMKK12.19712265
11WNK42.14843445
12SGK4942.07068975
13SGK2232.07068975
14TESK21.99978095
15WNK11.94026121
16LIMK11.85062801
17NTRK11.81616629
18CDK191.81007443
19MET1.77081110
20CAMK2B1.74511954
21BCR1.73803799
22PLK21.69017465
23PNCK1.65696968
24ROCK21.56257167
25CLK11.51962624
26RIPK11.47554818
27RIPK41.40460369
28CASK1.39923237
29CAMK2D1.37811502
30PAK61.37511439
31PRKD31.33607731
32CSNK1G31.31500085
33CSNK1A1L1.30279803
34EPHA41.29559034
35MARK11.27139237
36NEK61.26096681
37MARK21.20031663
38CAMK2G1.16325997
39ALK1.14047631
40DYRK21.13682675
41LATS21.09823235
42PRKD11.09020250
43CSNK1G21.05902002
44PHKG21.05460110
45PHKG11.05460110
46PRKCG1.02512115
47PINK10.99877820
48CDK50.97597792
49DYRK1A0.97406425
50FGR0.97387030
51CSNK1G10.97274363
52TYRO30.96036304
53DAPK10.95782970
54CAMK2A0.95499903
55SGK20.92389703
56MUSK0.91573108
57TNK20.91029401
58MST40.88440095
59KSR20.87615364
60NTRK20.86775149
61STK380.85445905
62SIK20.83636785
63SGK30.83133293
64CDK140.80385359
65BRSK10.80020340
66MAP3K110.79813532
67CDK150.77983370
68NTRK30.76851333
69ILK0.75576441
70PRKCE0.73369101
71DAPK30.73257149
72MAPK150.73177568
73CDK180.72337126
74PAK30.71807636
75MAP3K130.70288641
76PRKCQ0.69713163
77PDPK10.68717630
78CDK11A0.67513783
79CAMK1G0.67430099
80BMPR20.65193664
81GSK3A0.63516842
82MAPK130.63177526
83PRKCZ0.62624544
84RPS6KA30.61597955
85GRK70.60347084
86MAP3K40.58971995
87RPS6KA50.56059061
88BRAF0.55636990
89MAP2K20.53594136
90FYN0.53373916
91CAMKK20.53009060
92TESK10.52700582
93MINK10.51410975
94MAP3K90.51345245
95PRKCH0.50955399
96CAMK40.50815084
97PRKG10.50514951
98TNIK0.49177004
99MAP3K20.48342881
100FES0.47912065
101LMTK20.47808588
102CSNK1A10.46759381
103GRK50.46074972
104ROCK10.46073204
105PRKACB0.45768529
106PDK10.44832056
107MKNK10.44261316
108STK110.43319320
109CSNK1D0.42985797
110KSR10.41810030
111IRAK20.41125836
112PRPF4B0.41120193
113MAP3K10.38820273
114RAF10.37948111
115RET0.37808671
116DDR20.36123945
117PRKCA0.35679135
118MAPK100.35618382
119BMX0.35488082
120PAK10.34972691
121PRKACA0.34651579
122DMPK0.34274939
123SGK10.34076468
124CAMK10.33024415
125MAP2K70.32865330
126ADRBK20.32786932
127PIK3CA0.32311930
128MAP2K40.32197718
129MAPK40.32037125
130MAPK120.31724809
131ERBB20.31710009
132ARAF0.31469795
133PDK20.31341055
134PRKG20.31326151
135PRKD20.30251710
136PAK20.29902481
137SRC0.29696994
138CSNK1E0.29291511
139BMPR1B0.29286224

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.06385618
2Fatty acid elongation_Homo sapiens_hsa000624.40817619
3Steroid biosynthesis_Homo sapiens_hsa001003.87990321
4Nitrogen metabolism_Homo sapiens_hsa009103.56344219
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.94792154
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.75896538
7Ether lipid metabolism_Homo sapiens_hsa005652.69565425
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.42552874
9Vitamin B6 metabolism_Homo sapiens_hsa007502.05752077
10Histidine metabolism_Homo sapiens_hsa003401.87898327
11GABAergic synapse_Homo sapiens_hsa047271.81519158
12Sulfur metabolism_Homo sapiens_hsa009201.81277664
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.73558455
14Glutamatergic synapse_Homo sapiens_hsa047241.67980966
15beta-Alanine metabolism_Homo sapiens_hsa004101.47288922
16Linoleic acid metabolism_Homo sapiens_hsa005911.45964193
17Cocaine addiction_Homo sapiens_hsa050301.36884796
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.36239042
19Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.34511561
20Morphine addiction_Homo sapiens_hsa050321.33989626
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.31450123
22Serotonergic synapse_Homo sapiens_hsa047261.30122616
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29064101
24Butanoate metabolism_Homo sapiens_hsa006501.28058334
25Axon guidance_Homo sapiens_hsa043601.26985978
26Circadian entrainment_Homo sapiens_hsa047131.24598522
27Estrogen signaling pathway_Homo sapiens_hsa049151.21329919
28Sphingolipid metabolism_Homo sapiens_hsa006001.16095414
29Long-term depression_Homo sapiens_hsa047301.13117807
30Gastric acid secretion_Homo sapiens_hsa049711.12894617
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12665273
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11986027
33Protein export_Homo sapiens_hsa030601.07152537
34Synaptic vesicle cycle_Homo sapiens_hsa047211.07056031
35Salivary secretion_Homo sapiens_hsa049701.07009937
36Oxidative phosphorylation_Homo sapiens_hsa001901.06561575
37Glioma_Homo sapiens_hsa052141.05897208
38Dopaminergic synapse_Homo sapiens_hsa047281.00695718
39Arginine and proline metabolism_Homo sapiens_hsa003301.00321012
40Nicotine addiction_Homo sapiens_hsa050330.99840817
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98683312
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98607887
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94468400
44cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93972680
45Parkinsons disease_Homo sapiens_hsa050120.91569816
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90032433
47Renal cell carcinoma_Homo sapiens_hsa052110.89279193
48Cholinergic synapse_Homo sapiens_hsa047250.87765330
49Alzheimers disease_Homo sapiens_hsa050100.86763780
50Inositol phosphate metabolism_Homo sapiens_hsa005620.86368410
51Thyroid hormone synthesis_Homo sapiens_hsa049180.86224807
52Amphetamine addiction_Homo sapiens_hsa050310.84287065
53Renin secretion_Homo sapiens_hsa049240.82987221
54Sphingolipid signaling pathway_Homo sapiens_hsa040710.82184016
55Rap1 signaling pathway_Homo sapiens_hsa040150.77140233
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.76943481
57Oocyte meiosis_Homo sapiens_hsa041140.75747999
58Glycerophospholipid metabolism_Homo sapiens_hsa005640.75318646
59Collecting duct acid secretion_Homo sapiens_hsa049660.74451352
60Olfactory transduction_Homo sapiens_hsa047400.74267508
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73915142
62Gap junction_Homo sapiens_hsa045400.73593232
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73368967
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72849408
65Cardiac muscle contraction_Homo sapiens_hsa042600.71984790
66Mineral absorption_Homo sapiens_hsa049780.71001247
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.70915025
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70638247
69Pancreatic secretion_Homo sapiens_hsa049720.70563668
70Vibrio cholerae infection_Homo sapiens_hsa051100.70004448
71Tight junction_Homo sapiens_hsa045300.68387424
72Dorso-ventral axis formation_Homo sapiens_hsa043200.68112659
73VEGF signaling pathway_Homo sapiens_hsa043700.67456724
74Fatty acid metabolism_Homo sapiens_hsa012120.67145629
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66835881
76MAPK signaling pathway_Homo sapiens_hsa040100.66103986
77Insulin secretion_Homo sapiens_hsa049110.64908236
78Endocytosis_Homo sapiens_hsa041440.64582547
79Ras signaling pathway_Homo sapiens_hsa040140.64091797
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62578378
81Propanoate metabolism_Homo sapiens_hsa006400.61532544
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60927277
83Ovarian steroidogenesis_Homo sapiens_hsa049130.60871525
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.60750939
85Taste transduction_Homo sapiens_hsa047420.60163706
86Lysosome_Homo sapiens_hsa041420.59316741
87Long-term potentiation_Homo sapiens_hsa047200.59250258
88Choline metabolism in cancer_Homo sapiens_hsa052310.58624815
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57563984
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56460832
91cAMP signaling pathway_Homo sapiens_hsa040240.51847033
92Vitamin digestion and absorption_Homo sapiens_hsa049770.50960849
93Type II diabetes mellitus_Homo sapiens_hsa049300.50615963
94Phototransduction_Homo sapiens_hsa047440.48795543
95Circadian rhythm_Homo sapiens_hsa047100.48769378
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48728295
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47983963
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47863778
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47557145
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46150092
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45790846
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44851728
103Arachidonic acid metabolism_Homo sapiens_hsa005900.44143140
104Fatty acid biosynthesis_Homo sapiens_hsa000610.41968126
105Glucagon signaling pathway_Homo sapiens_hsa049220.41938485
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41219536
107ErbB signaling pathway_Homo sapiens_hsa040120.41140428
108Prion diseases_Homo sapiens_hsa050200.40841246
109Oxytocin signaling pathway_Homo sapiens_hsa049210.40573667
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40052220
111ABC transporters_Homo sapiens_hsa020100.39369788
112Calcium signaling pathway_Homo sapiens_hsa040200.38613639
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37862023
114Glutathione metabolism_Homo sapiens_hsa004800.37395727
115Bile secretion_Homo sapiens_hsa049760.37133156
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37055234
117GnRH signaling pathway_Homo sapiens_hsa049120.36755052
118Phagosome_Homo sapiens_hsa041450.36269924
119Dilated cardiomyopathy_Homo sapiens_hsa054140.35126226
120Melanogenesis_Homo sapiens_hsa049160.33706889
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33001425
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32466270
123Rheumatoid arthritis_Homo sapiens_hsa053230.31763870
124Folate biosynthesis_Homo sapiens_hsa007900.31266496
125Alcoholism_Homo sapiens_hsa050340.30235712
126Arginine biosynthesis_Homo sapiens_hsa002200.29832593
127mTOR signaling pathway_Homo sapiens_hsa041500.28314009
128AMPK signaling pathway_Homo sapiens_hsa041520.26880790
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26542640
130Wnt signaling pathway_Homo sapiens_hsa043100.23788590
131Insulin signaling pathway_Homo sapiens_hsa049100.23081379

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