HAPLN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the hyaluronan and proteoglycan binding link protein gene family. The protein encoded by this gene may function in hyaluronic acid binding and cell adhesion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1superoxide anion generation (GO:0042554)7.08730618
2response to gravity (GO:0009629)6.89993849
3notochord development (GO:0030903)5.37565436
4cellular response to type I interferon (GO:0071357)5.31428384
5type I interferon signaling pathway (GO:0060337)5.31428384
6response to type I interferon (GO:0034340)5.26616698
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.24083068
8positive regulation of gamma-delta T cell activation (GO:0046645)5.12207507
9endocardial cushion morphogenesis (GO:0003203)5.09217130
10negative regulation of cell killing (GO:0031342)5.06779893
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.06779893
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.02618840
13substrate-dependent cell migration (GO:0006929)4.94998250
14regulation of T cell tolerance induction (GO:0002664)4.92164031
15positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.74633479
16regulation of T-helper 1 cell differentiation (GO:0045625)4.68141588
17antigen processing and presentation of endogenous antigen (GO:0019883)4.68096572
18mesenchyme morphogenesis (GO:0072132)4.58911214
19glutamine family amino acid biosynthetic process (GO:0009084)4.58525132
20tolerance induction (GO:0002507)4.53202593
21limb bud formation (GO:0060174)4.46459232
22regulation of chronic inflammatory response (GO:0002676)4.42518735
23NIK/NF-kappaB signaling (GO:0038061)4.38861752
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.36233095
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.34961913
26T cell migration (GO:0072678)4.27402983
27regulation of dendritic cell antigen processing and presentation (GO:0002604)4.24639811
28regulation of type I interferon-mediated signaling pathway (GO:0060338)4.17981216
29negative regulation of interleukin-12 production (GO:0032695)4.11509298
30positive regulation of tolerance induction (GO:0002645)4.11150335
31negative regulation of axon extension involved in axon guidance (GO:0048843)4.10256206
32regulation of tolerance induction (GO:0002643)4.04899271
33positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.93437984
34negative thymic T cell selection (GO:0045060)3.93413410
35regulation of gamma-delta T cell activation (GO:0046643)3.92623754
36regulation of regulatory T cell differentiation (GO:0045589)3.91514851
37lateral sprouting from an epithelium (GO:0060601)3.86254045
38negative T cell selection (GO:0043383)3.85444449
39myeloid dendritic cell differentiation (GO:0043011)3.79404951
40regulation of interleukin-2 biosynthetic process (GO:0045076)3.77622427
41face development (GO:0060324)3.73786108
42negative regulation of T cell mediated immunity (GO:0002710)3.64193465
43positive regulation of smooth muscle cell migration (GO:0014911)3.63216907
44interferon-gamma-mediated signaling pathway (GO:0060333)3.61926890
45negative regulation of cytokine production involved in immune response (GO:0002719)3.61292808
46dermatan sulfate metabolic process (GO:0030205)3.59820393
47lung lobe morphogenesis (GO:0060463)3.57465570
48proline transport (GO:0015824)3.57416712
49positive regulation of type 2 immune response (GO:0002830)3.54258736
50regulation of gamma-delta T cell differentiation (GO:0045586)3.51021555
51thymic T cell selection (GO:0045061)3.50500607
52facial nerve structural organization (GO:0021612)3.48828411
53heart valve formation (GO:0003188)3.44707946
54dermatan sulfate biosynthetic process (GO:0030208)3.44267450
55negative regulation of viral genome replication (GO:0045071)3.43174769
56mesenchymal-epithelial cell signaling (GO:0060638)3.42560217
57regulation of interferon-alpha production (GO:0032647)3.42435279
58ganglion development (GO:0061548)3.39608605
59lymphangiogenesis (GO:0001946)3.38830454
60response to muramyl dipeptide (GO:0032495)3.38035844
61cellular response to virus (GO:0098586)3.37699946
62myeloid dendritic cell activation (GO:0001773)3.35950467
63regulation of non-canonical Wnt signaling pathway (GO:2000050)3.35272493
64response to interleukin-15 (GO:0070672)3.34249129
65lymph vessel development (GO:0001945)3.34236268
66leukocyte aggregation (GO:0070486)3.32069200
67immunoglobulin mediated immune response (GO:0016064)3.31407346
68positive thymic T cell selection (GO:0045059)3.30829665
69negative regulation of axon guidance (GO:1902668)3.26481820
70alanine transport (GO:0032328)3.26176242
71defense response to protozoan (GO:0042832)3.25891402
72T cell selection (GO:0045058)3.24755310
73metanephric mesenchyme development (GO:0072075)3.24301604
74response to interferon-alpha (GO:0035455)3.22141059
75regulation of alpha-beta T cell proliferation (GO:0046640)3.21850073
76germinal center formation (GO:0002467)3.20574712
77superoxide metabolic process (GO:0006801)3.19759709
78response to interferon-beta (GO:0035456)3.18550954
79negative regulation of innate immune response (GO:0045824)3.17944753
80regulation of antigen processing and presentation (GO:0002577)3.17732919
81lymphocyte chemotaxis (GO:0048247)3.17346998
82positive regulation of interferon-alpha production (GO:0032727)3.16610423
83JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.16533306
84positive regulation of antigen processing and presentation (GO:0002579)3.15245313
85heart valve morphogenesis (GO:0003179)3.14737655
86axon extension involved in axon guidance (GO:0048846)3.14466414
87neuron projection extension involved in neuron projection guidance (GO:1902284)3.14466414
88lipopolysaccharide-mediated signaling pathway (GO:0031663)3.13681296
89dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.13362905
90regulation of type 2 immune response (GO:0002828)3.13231508
91detection of other organism (GO:0098543)3.12694901
92kidney mesenchyme development (GO:0072074)3.12565342
93positive regulation of natural killer cell differentiation (GO:0032825)3.12528686
94positive regulation of smoothened signaling pathway (GO:0045880)3.12372218
95positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.11207876
96regulation of vitamin D biosynthetic process (GO:0060556)3.10122376
97detection of bacterium (GO:0016045)3.09836642
98positive regulation of cardiac muscle cell proliferation (GO:0060045)3.08863587
99positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.08805307
100cell proliferation involved in kidney development (GO:0072111)3.07654408
101regulation of isotype switching to IgG isotypes (GO:0048302)3.06769895
102cranial nerve structural organization (GO:0021604)3.06425128
103regulation of interferon-beta biosynthetic process (GO:0045357)3.06419290
104chondrocyte differentiation (GO:0002062)3.06341161
105cerebral cortex radially oriented cell migration (GO:0021799)3.06163395
106inositol phosphate-mediated signaling (GO:0048016)3.05882569
107macrophage activation involved in immune response (GO:0002281)3.05716814
108paraxial mesoderm development (GO:0048339)3.02824686
109regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.02616668
110interferon-gamma secretion (GO:0072643)3.02377690
111response to protozoan (GO:0001562)3.01767116
112C4-dicarboxylate transport (GO:0015740)3.00574679
113modulation by symbiont of host immune response (GO:0052553)3.00265696
114positive regulation by symbiont of host defense response (GO:0052509)3.00265696
115modulation by symbiont of host defense response (GO:0052031)3.00265696
116modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.00265696
117modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.00265696
118positive regulation by organism of defense response of other organism involved in symbiotic interact3.00265696
119negative regulation of type I interferon production (GO:0032480)2.99946230
120negative regulation of erythrocyte differentiation (GO:0045647)2.97574426
121regulation of axon extension involved in axon guidance (GO:0048841)2.95954653
122positive regulation of interleukin-2 production (GO:0032743)2.94897036
123cellular response to interferon-beta (GO:0035458)2.92707630
124regulation of cytokine secretion involved in immune response (GO:0002739)2.92438971
125mesenchymal cell proliferation (GO:0010463)2.91471481
126regulation of glucose import in response to insulin stimulus (GO:2001273)2.91345963
127cellular response to interleukin-15 (GO:0071350)2.91257835
128positive T cell selection (GO:0043368)2.91037300
129negative regulation of production of molecular mediator of immune response (GO:0002701)2.89139879
130lymphocyte migration (GO:0072676)2.88207305
131gap junction assembly (GO:0016264)2.88029312
132G-protein coupled receptor internalization (GO:0002031)2.87615936
133cellular response to interferon-gamma (GO:0071346)2.87610493
134atrioventricular valve morphogenesis (GO:0003181)2.87331930
135regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.86934959
136dendritic cell differentiation (GO:0097028)2.86597095
137cellular response to interferon-alpha (GO:0035457)2.86355140
138regulation of response to interferon-gamma (GO:0060330)2.86312030
139response to peptidoglycan (GO:0032494)2.85300168
140positive regulation of cartilage development (GO:0061036)2.84553291
141negative regulation of lymphocyte mediated immunity (GO:0002707)2.84316486
142positive regulation of neuroblast proliferation (GO:0002052)2.83692634
143positive regulation of alpha-beta T cell proliferation (GO:0046641)2.80327003
144regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.80029572
145regulation of natural killer cell mediated immunity (GO:0002715)2.80029572
146positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.79657134
147regulation of MHC class I biosynthetic process (GO:0045343)2.79236313
148positive regulation of protein kinase C signaling (GO:0090037)2.77606510
149cell aggregation (GO:0098743)2.77229746
150cartilage condensation (GO:0001502)2.77229746
151regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.77015020
152B cell mediated immunity (GO:0019724)2.76024837
153positive regulation of cardiac muscle tissue growth (GO:0055023)2.75763240
154positive regulation of isotype switching (GO:0045830)2.75702651
155Notch signaling involved in heart development (GO:0061314)2.72898949
156establishment of planar polarity (GO:0001736)2.72298483
157establishment of tissue polarity (GO:0007164)2.72298483
158cardiac right ventricle morphogenesis (GO:0003215)2.71135455
159retina vasculature morphogenesis in camera-type eye (GO:0061299)2.70320076
160endothelial cell morphogenesis (GO:0001886)2.68915323
161chondroitin sulfate biosynthetic process (GO:0030206)2.66821753
162endothelium development (GO:0003158)2.65393035
163regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.64330206
164cell proliferation involved in metanephros development (GO:0072203)2.62667112
165regulation of vasculogenesis (GO:2001212)2.61304178
166positive regulation of positive chemotaxis (GO:0050927)2.60366407
167negative chemotaxis (GO:0050919)2.59774244
168mesodermal cell differentiation (GO:0048333)2.58541189
169regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.58167206
170chondrocyte development (GO:0002063)2.57264223
171positive regulation of cardiac muscle tissue development (GO:0055025)2.55856106
172regulation of axon guidance (GO:1902667)2.55194939
173positive regulation of heart growth (GO:0060421)2.54118441
174regulation of timing of cell differentiation (GO:0048505)2.53827994
175lung-associated mesenchyme development (GO:0060484)2.52696751
176embryonic cranial skeleton morphogenesis (GO:0048701)2.52363998
177cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.52019287
178cell surface receptor signaling pathway involved in heart development (GO:0061311)2.50847238
179vascular endothelial growth factor signaling pathway (GO:0038084)2.50520826
180temperature homeostasis (GO:0001659)2.48406284
181retinal ganglion cell axon guidance (GO:0031290)2.47917790
182Rac protein signal transduction (GO:0016601)2.47182922
183mesenchymal cell differentiation involved in renal system development (GO:2001012)2.45959156
184mesenchymal cell differentiation involved in kidney development (GO:0072161)2.45959156
185regulation of inositol phosphate biosynthetic process (GO:0010919)2.45514883
186negative regulation of myoblast differentiation (GO:0045662)2.45295029
187regulation of positive chemotaxis (GO:0050926)2.44917112
188endoderm formation (GO:0001706)2.42938137
189negative regulation of astrocyte differentiation (GO:0048712)2.42700675
190embryonic skeletal joint morphogenesis (GO:0060272)2.40427228
191intra-S DNA damage checkpoint (GO:0031573)2.37795765
192cardiac ventricle morphogenesis (GO:0003208)2.37763114
193homocysteine metabolic process (GO:0050667)2.37313825
194regulation of neuroblast proliferation (GO:1902692)2.36748037
195outflow tract septum morphogenesis (GO:0003148)2.36633163
196glutamine metabolic process (GO:0006541)2.35742984
197negative regulation of complement activation (GO:0045916)2.34896029
198epithelial to mesenchymal transition (GO:0001837)2.34057138
199positive regulation of muscle tissue development (GO:1901863)2.33955907

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.61170051
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.38112312
3* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.06004854
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.94759727
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.93873693
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.35300160
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.08098044
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.04825939
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.88609725
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.86570837
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.76749469
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.76123133
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.73613849
14EZH2_22144423_ChIP-Seq_EOC_Human2.67257478
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.65596664
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58730199
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.57707530
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.54786954
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.50946683
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.49064758
21CBX2_27304074_Chip-Seq_ESCs_Mouse2.46192177
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.45347158
23MYC_22102868_ChIP-Seq_BL_Human2.43757655
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43185488
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.39858325
26* MAF_26560356_Chip-Seq_TH1_Human2.39216401
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.37873676
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.37713881
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.33056268
30VDR_21846776_ChIP-Seq_THP-1_Human2.30645094
31GBX2_23144817_ChIP-Seq_PC3_Human2.30166860
32RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29143556
33EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29143556
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28504854
35JARID2_20075857_ChIP-Seq_MESCs_Mouse2.24832853
36ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21180944
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20609270
38RUNX_20019798_ChIP-Seq_JUKART_Human2.18435544
39MYB_26560356_Chip-Seq_TH2_Human2.14897001
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.14026536
41KDM2B_26808549_Chip-Seq_SUP-B15_Human2.13267277
42AR_21572438_ChIP-Seq_LNCaP_Human2.13142644
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12276539
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.10773288
45RNF2_27304074_Chip-Seq_ESCs_Mouse2.10176233
46ELK3_25401928_ChIP-Seq_HUVEC_Human2.07285624
47IGF1R_20145208_ChIP-Seq_DFB_Human2.04357314
48UTX_26944678_Chip-Seq_JUKART_Human2.03783135
49MYB_21317192_ChIP-Seq_ERMYB_Mouse2.00562368
50TCF7_22412390_ChIP-Seq_EML_Mouse1.99191069
51FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.96316088
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95683244
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.93639308
54KDM2B_26808549_Chip-Seq_DND41_Human1.92664525
55MAF_26560356_Chip-Seq_TH2_Human1.92234795
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.91217467
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.90859733
58MYB_26560356_Chip-Seq_TH1_Human1.89605747
59TP53_18474530_ChIP-ChIP_U2OS_Human1.88756348
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87765016
61MTF2_20144788_ChIP-Seq_MESCs_Mouse1.86953019
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.84701285
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82777021
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.80803881
65VDR_24763502_ChIP-Seq_THP-1_Human1.80584828
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.73800375
67CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.73539292
68TP63_17297297_ChIP-ChIP_HaCaT_Human1.72833827
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.71788350
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.71036347
71TP53_20018659_ChIP-ChIP_R1E_Mouse1.68890660
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.68006873
73FUS_26573619_Chip-Seq_HEK293_Human1.67437525
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65962120
75KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.64936755
76KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.64936755
77KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.64936755
78RARG_19884340_ChIP-ChIP_MEFs_Mouse1.63314306
79P300_19829295_ChIP-Seq_ESCs_Human1.62833739
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62429439
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61927864
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.61867007
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.60394682
84LXR_22292898_ChIP-Seq_THP-1_Human1.60347416
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59747068
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.59747068
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59484576
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58414594
89IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57068273
90SPI1_23547873_ChIP-Seq_NB4_Human1.56124460
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47304005
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47196207
93TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.45047281
94SMAD4_21799915_ChIP-Seq_A2780_Human1.44972152
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43277299
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42883807
97TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.42716003
98FLI1_27457419_Chip-Seq_LIVER_Mouse1.42241243
99TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41457467
100NFE2_27457419_Chip-Seq_LIVER_Mouse1.40692590
101EWS_26573619_Chip-Seq_HEK293_Human1.40148897
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38901585
103RING1B_27294783_Chip-Seq_NPCs_Mouse1.37912001
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.37065577
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36998224
106RNF2_27304074_Chip-Seq_NSC_Mouse1.36325674
107SMAD3_21741376_ChIP-Seq_EPCs_Human1.36091186
108SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34723678
109SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34292218
110KDM2B_26808549_Chip-Seq_JURKAT_Human1.34119657
111CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33606625
112WT1_19549856_ChIP-ChIP_CCG9911_Human1.32944143
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32884524
114MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31726328
115CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31136340
116SPI1_23127762_ChIP-Seq_K562_Human1.30321065
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28478064
118SMAD_19615063_ChIP-ChIP_OVARY_Human1.28328912
119SCL_19346495_ChIP-Seq_HPC-7_Human1.28236833
120CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26034696
121EZH2_27294783_Chip-Seq_NPCs_Mouse1.25857567
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25847550
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24556366
124HTT_18923047_ChIP-ChIP_STHdh_Human1.24475135
125NANOG_18555785_Chip-Seq_ESCs_Mouse1.24100574
126PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23897546
127TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23066107
128LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22155254
129PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21964402
130GATA3_27048872_Chip-Seq_THYMUS_Human1.21641728
131POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21641182
132BCAT_22108803_ChIP-Seq_LS180_Human1.20895499
133RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19480953
134NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19358022
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19352481
136RING1B_27294783_Chip-Seq_ESCs_Mouse1.18840775
137* RACK7_27058665_Chip-Seq_MCF-7_Human1.17742818
138FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16929502
139STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16675193
140MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15031894
141TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14810373
142OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13903442
143POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13418597
144ER_23166858_ChIP-Seq_MCF-7_Human1.13101032
145SOX2_18555785_Chip-Seq_ESCs_Mouse1.12392889
146CJUN_26792858_Chip-Seq_BT549_Human1.12371803
147PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12250761
148SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12064354
149NMYC_18555785_Chip-Seq_ESCs_Mouse1.10686077
150PU_27001747_Chip-Seq_BMDM_Mouse1.10607495
151PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09230632
152STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08425616
153RXR_22108803_ChIP-Seq_LS180_Human1.08384747
154GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07636616
155TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06403312
156Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06212807
157GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06135192
158P53_22387025_ChIP-Seq_ESCs_Mouse1.06055006
159CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05903602
160ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05817184
161* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05509011
162TCF4_18268006_ChIP-ChIP_LS174T_Human1.03382923
163* SA1_27219007_Chip-Seq_ERYTHROID_Human1.03324198
164SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03137216
165CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02903588
166RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01981650
167STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01651328
168STAT3_18555785_Chip-Seq_ESCs_Mouse1.01408013
169EP300_21415370_ChIP-Seq_HL-1_Mouse1.00866410
170CMYC_18555785_Chip-Seq_ESCs_Mouse1.00632652
171TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00577808
172CDX2_20551321_ChIP-Seq_CACO-2_Human1.00011435
173ISL1_27105846_Chip-Seq_CPCs_Mouse0.99081167
174TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98835106
175AR_19668381_ChIP-Seq_PC3_Human0.98745999
176CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98715451
177AR_25329375_ChIP-Seq_VCAP_Human0.98647428
178SMAD3_21741376_ChIP-Seq_HESCs_Human0.98186467
179FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97957066
180* NCOR1_26117541_ChIP-Seq_K562_Human0.97199301
181CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96692165
182LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95719169
183GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95150115
184KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94365477
185KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92648823
186GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91789890
187KDM2B_26808549_Chip-Seq_K562_Human0.91095315
188VDR_24787735_ChIP-Seq_THP-1_Human0.88084320
189GATA1_19941827_ChIP-Seq_MEL_Mouse0.88067625
190GATA3_26560356_Chip-Seq_TH2_Human0.87372881
191CTCF_26484167_Chip-Seq_Bcells_Mouse0.86849735
192SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86536116
193ELF1_20517297_ChIP-Seq_JURKAT_Human0.86197779
194TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85589317
195BCOR_27268052_Chip-Seq_Bcells_Human0.85265553
196NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85182990
197CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83791059

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system5.06231678
2MP0003724_increased_susceptibility_to4.18211469
3MP0003303_peritoneal_inflammation4.15727534
4MP0010030_abnormal_orbit_morphology3.91842747
5MP0003436_decreased_susceptibility_to3.70187162
6MP0005257_abnormal_intraocular_pressure3.49826739
7MP0001346_abnormal_lacrimal_gland3.49589103
8MP0000566_synostosis3.32888608
9MP0001835_abnormal_antigen_presentation3.23858961
10MP0002254_reproductive_system_inflammat3.06581958
11MP0003763_abnormal_thymus_physiology3.05123790
12MP0005671_abnormal_response_to3.04651249
13MP0001879_abnormal_lymphatic_vessel3.03453395
14MP0006082_CNS_inflammation3.01751710
15MP0003300_gastrointestinal_ulcer2.97113430
16MP0009785_altered_susceptibility_to2.94083321
17MP0001299_abnormal_eye_distance/2.93242701
18MP0005000_abnormal_immune_tolerance2.86670926
19MP0002148_abnormal_hypersensitivity_rea2.77058115
20MP0001790_abnormal_immune_system2.75100088
21MP0005387_immune_system_phenotype2.75100088
22MP0002735_abnormal_chemical_nociception2.71313762
23MP0009250_abnormal_appendicular_skeleto2.63932269
24MP0001800_abnormal_humoral_immune2.63810210
25MP0004510_myositis2.60706796
26MP0005025_abnormal_response_to2.57260241
27MP0002723_abnormal_immune_serum2.39318686
28MP0000685_abnormal_immune_system2.38567571
29MP0009333_abnormal_splenocyte_physiolog2.38435013
30MP0000762_abnormal_tongue_morphology2.32503437
31MP0002452_abnormal_antigen_presenting2.32217501
32MP0004947_skin_inflammation2.30106474
33MP0002419_abnormal_innate_immunity2.26394409
34MP0009697_abnormal_copulation2.22006088
35MP0010155_abnormal_intestine_physiology2.19185233
36MP0001533_abnormal_skeleton_physiology2.16568238
37MP0001819_abnormal_immune_cell2.16139807
38MP0002420_abnormal_adaptive_immunity2.15084099
39MP0002249_abnormal_larynx_morphology2.11480870
40MP0003566_abnormal_cell_adhesion2.00498919
41MP0002876_abnormal_thyroid_physiology1.99847808
42MP0002282_abnormal_trachea_morphology1.99510682
43MP0004272_abnormal_basement_membrane1.95231067
44MP0001873_stomach_inflammation1.94709677
45MP0003941_abnormal_skin_development1.94479371
46MP0009384_cardiac_valve_regurgitation1.93957494
47MP0000049_abnormal_middle_ear1.89179241
48MP0002405_respiratory_system_inflammati1.85606800
49MP0001502_abnormal_circadian_rhythm1.85545170
50MP0004484_altered_response_of1.82862204
51MP0009278_abnormal_bone_marrow1.78229984
52MP0002127_abnormal_cardiovascular_syste1.77611092
53MP0002398_abnormal_bone_marrow1.72309752
54MP0000716_abnormal_immune_system1.70762492
55MP0008438_abnormal_cutaneous_collagen1.69754001
56MP0002163_abnormal_gland_morphology1.69126726
57MP0009053_abnormal_anal_canal1.68119721
58MP0004742_abnormal_vestibular_system1.67663339
59MP0001845_abnormal_inflammatory_respons1.64941701
60MP0003136_yellow_coat_color1.61929716
61MP0005083_abnormal_biliary_tract1.61774268
62MP0001853_heart_inflammation1.60155044
63MP0003448_altered_tumor_morphology1.55873787
64MP0005409_darkened_coat_color1.54549189
65MP0005058_abnormal_lysosome_morphology1.54194171
66MP0005451_abnormal_body_composition1.51576055
67MP0005310_abnormal_salivary_gland1.50900516
68MP0000163_abnormal_cartilage_morphology1.50543921
69MP0002138_abnormal_hepatobiliary_system1.49510723
70MP0000858_altered_metastatic_potential1.47611179
71MP0002233_abnormal_nose_morphology1.47395193
72MP0000703_abnormal_thymus_morphology1.46895123
73MP0002938_white_spotting1.44689588
74MP0006138_congestive_heart_failure1.44121031
75MP0004134_abnormal_chest_morphology1.41952329
76MP0005165_increased_susceptibility_to1.41666218
77MP0008469_abnormal_protein_level1.40138369
78MP0009840_abnormal_foam_cell1.39987895
79MP0002722_abnormal_immune_system1.39187450
80MP0003122_maternal_imprinting1.37462553
81MP0002429_abnormal_blood_cell1.36075996
82MP0002998_abnormal_bone_remodeling1.35977365
83MP0005646_abnormal_pituitary_gland1.35468027
84MP0000689_abnormal_spleen_morphology1.35028249
85MP0003453_abnormal_keratinocyte_physiol1.35023658
86MP0009764_decreased_sensitivity_to1.33515667
87MP0003866_abnormal_defecation1.32291259
88MP0001440_abnormal_grooming_behavior1.30739633
89MP0002972_abnormal_cardiac_muscle1.29921637
90MP0000026_abnormal_inner_ear1.28006045
91MP0001851_eye_inflammation1.27448401
92MP0000383_abnormal_hair_follicle1.26376703
93MP0003191_abnormal_cellular_cholesterol1.24956520
94MP0002277_abnormal_respiratory_mucosa1.24116944
95MP0006276_abnormal_autonomic_nervous1.23414065
96MP0008004_abnormal_stomach_pH1.23204024
97MP0005379_endocrine/exocrine_gland_phen1.21672619
98MP0005508_abnormal_skeleton_morphology1.19820056
99MP0000465_gastrointestinal_hemorrhage1.19712191
100MP0003279_aneurysm1.19102189
101MP0001270_distended_abdomen1.19095323
102MP0003385_abnormal_body_wall1.17160855
103MP0003755_abnormal_palate_morphology1.16847383
104MP0003646_muscle_fatigue1.16741178
105MP0000372_irregular_coat_pigmentation1.16452128
106MP0002177_abnormal_outer_ear1.14289606
107MP0003935_abnormal_craniofacial_develop1.13710313
108MP0000537_abnormal_urethra_morphology1.13444929
109MP0003937_abnormal_limbs/digits/tail_de1.13208457
110MP0005390_skeleton_phenotype1.12989158
111MP0003075_altered_response_to1.12061106
112MP0000767_abnormal_smooth_muscle1.11148565
113MP0006292_abnormal_olfactory_placode1.07275888
114MP0002734_abnormal_mechanical_nocicepti1.07061936
115MP0005503_abnormal_tendon_morphology1.06670062
116MP0002089_abnormal_postnatal_growth/wei1.05038989
117MP0000678_abnormal_parathyroid_gland1.04032207
118MP0000343_altered_response_to1.02722199
119MP0000749_muscle_degeneration1.02440236
120MP0000490_abnormal_crypts_of1.02390309
121MP0003172_abnormal_lysosome_physiology1.02246322
122MP0003137_abnormal_impulse_conducting1.02221844
123MP0005464_abnormal_platelet_physiology1.00984747
124MP0003705_abnormal_hypodermis_morpholog0.99557337
125MP0002166_altered_tumor_susceptibility0.99273639
126MP0006054_spinal_hemorrhage0.98597796
127MP0003828_pulmonary_edema0.98550625
128MP0002115_abnormal_skeleton_extremities0.97819322
129MP0002098_abnormal_vibrissa_morphology0.97283297
130MP0001986_abnormal_taste_sensitivity0.96782573
131MP0001663_abnormal_digestive_system0.96162186
132MP0002116_abnormal_craniofacial_bone0.94408683
133MP0002109_abnormal_limb_morphology0.94278131
134MP0001177_atelectasis0.93899363
135MP0002009_preneoplasia0.93518557
136MP0005171_absent_coat_pigmentation0.93142539
137MP0005620_abnormal_muscle_contractility0.92640589
138MP0000681_abnormal_thyroid_gland0.92261875
139MP0005084_abnormal_gallbladder_morpholo0.92247287
140MP0005330_cardiomyopathy0.91876367
141MP0001348_abnormal_lacrimal_gland0.91829597
142MP0000604_amyloidosis0.91497506
143MP0004084_abnormal_cardiac_muscle0.90881038
144MP0000432_abnormal_head_morphology0.90447847
145MP0010352_gastrointestinal_tract_polyps0.89988544
146MP0005023_abnormal_wound_healing0.89213319
147MP0003942_abnormal_urinary_system0.88973828
148MP0005166_decreased_susceptibility_to0.88351013
149MP0005595_abnormal_vascular_smooth0.87686507
150MP0004808_abnormal_hematopoietic_stem0.87199512
151MP0004085_abnormal_heartbeat0.87180052
152MP0001545_abnormal_hematopoietic_system0.87037837
153MP0005397_hematopoietic_system_phenotyp0.87037837
154MP0004036_abnormal_muscle_relaxation0.86749576
155MP0003938_abnormal_ear_development0.86744779
156MP0009763_increased_sensitivity_to0.86396881
157MP0002113_abnormal_skeleton_development0.85314189
158MP0004133_heterotaxia0.85179803
159MP0002006_tumorigenesis0.83806561
160MP0000428_abnormal_craniofacial_morphol0.82761026
161MP0000462_abnormal_digestive_system0.82634388
162MP0004215_abnormal_myocardial_fiber0.82595128
163MP0003091_abnormal_cell_migration0.82175086
164MP0002933_joint_inflammation0.81950559
165MP0008260_abnormal_autophagy0.80334043
166MP0002736_abnormal_nociception_after0.79733938
167MP0003119_abnormal_digestive_system0.78800976
168MP0005164_abnormal_response_to0.77593860
169MP0001542_abnormal_bone_strength0.75746793
170MP0001849_ear_inflammation0.74980886
171MP0002733_abnormal_thermal_nociception0.74925000
172MP0001963_abnormal_hearing_physiology0.74880440
173MP0005076_abnormal_cell_differentiation0.73991024
174MP0003795_abnormal_bone_structure0.73590707
175MP0001243_abnormal_dermal_layer0.73267048
176MP0003878_abnormal_ear_physiology0.70315319
177MP0005377_hearing/vestibular/ear_phenot0.70315319
178MP0002128_abnormal_blood_circulation0.68438151
179MP0002932_abnormal_joint_morphology0.68252494
180MP0004883_abnormal_blood_vessel0.67908777
181MP0003123_paternal_imprinting0.67859400
182MP0000249_abnormal_blood_vessel0.65591577
183MP0005381_digestive/alimentary_phenotyp0.63671086
184MP0002332_abnormal_exercise_endurance0.63107113
185MP0003690_abnormal_glial_cell0.61560196
186MP0009765_abnormal_xenobiotic_induced0.60680885
187MP0002396_abnormal_hematopoietic_system0.58778642
188MP0004381_abnormal_hair_follicle0.58474452
189MP0005167_abnormal_blood-brain_barrier0.55803585
190MP0002796_impaired_skin_barrier0.54791247
191MP0004858_abnormal_nervous_system0.54293226

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.49216133
2Mesomelia (HP:0003027)5.48718403
3Myositis (HP:0100614)5.03119617
4Stomatitis (HP:0010280)4.99046507
5Orchitis (HP:0100796)4.83068553
6Optic neuritis (HP:0100653)4.75839281
7Retrobulbar optic neuritis (HP:0100654)4.75839281
8Epiphyseal dysplasia (HP:0002656)4.60980527
9Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)4.60499876
10Vitreoretinal degeneration (HP:0000655)4.57073102
11T lymphocytopenia (HP:0005403)4.31931986
12Median cleft lip (HP:0000161)4.28905900
13Recurrent bacterial skin infections (HP:0005406)4.07413198
14Abnormality of T cell number (HP:0011839)4.05250279
15Abnormality of macrophages (HP:0004311)3.96390938
16Abnormality of the frontal sinuses (HP:0002687)3.90187530
17Irregular epiphyses (HP:0010582)3.86868641
18Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.79939342
19Recurrent abscess formation (HP:0002722)3.69787382
20Increased IgM level (HP:0003496)3.65205688
21Neonatal short-limb short stature (HP:0008921)3.50055723
22Autoimmune hemolytic anemia (HP:0001890)3.46285807
23Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.45859066
24Mediastinal lymphadenopathy (HP:0100721)3.41103955
25Abnormality of the columella (HP:0009929)3.40265374
26Keratoconjunctivitis sicca (HP:0001097)3.38826891
27Recurrent fungal infections (HP:0002841)3.38796429
28Increased IgE level (HP:0003212)3.35993340
29Recurrent viral infections (HP:0004429)3.34087658
30Abnormal tarsal ossification (HP:0008369)3.33698713
31Vasculitis (HP:0002633)3.30946695
32Pustule (HP:0200039)3.26510156
33Abnormality of the phalanges of the 2nd finger (HP:0009541)3.26394538
34Hypoplastic ischia (HP:0003175)3.26102646
35Gastrointestinal infarctions (HP:0005244)3.19620241
36Aplasia involving bones of the upper limbs (HP:0009823)3.15074032
37Aplasia of the phalanges of the hand (HP:0009802)3.15074032
38Aplasia involving bones of the extremities (HP:0009825)3.15074032
39Pulmonary infiltrates (HP:0002113)3.14322129
40Small epiphyses (HP:0010585)3.12019064
41Keratoconjunctivitis (HP:0001096)3.11837658
42Abnormal delayed hypersensitivity skin test (HP:0002963)3.11558560
43Abnormality of the ischium (HP:0003174)3.00775161
44Systemic lupus erythematosus (HP:0002725)2.99288478
45Hemoptysis (HP:0002105)2.96883011
46Flat capital femoral epiphysis (HP:0003370)2.95766739
47Onycholysis (HP:0001806)2.93316573
48Spontaneous hematomas (HP:0007420)2.90617133
49Abnormality of T cells (HP:0002843)2.87939625
50Hematochezia (HP:0002573)2.82582153
51Hypergammaglobulinemia (HP:0010702)2.81776618
52Meningitis (HP:0001287)2.79477710
53Abnormality of the incisor (HP:0000676)2.79197298
54High anterior hairline (HP:0009890)2.78144486
55Recurrent skin infections (HP:0001581)2.76070865
56Abnormality of incisor morphology (HP:0011063)2.71605952
57Distal lower limb muscle weakness (HP:0009053)2.71430797
58Congenital, generalized hypertrichosis (HP:0004540)2.67465506
59Encephalitis (HP:0002383)2.67329685
60Obstructive lung disease (HP:0006536)2.66740061
61Chronic obstructive pulmonary disease (HP:0006510)2.66740061
62Lymphopenia (HP:0001888)2.63845212
63Autoimmune thrombocytopenia (HP:0001973)2.62624822
64Facial cleft (HP:0002006)2.61167894
65Gingivitis (HP:0000230)2.60596877
66Abnormality of cells of the lymphoid lineage (HP:0012140)2.60353851
67Interstitial pulmonary disease (HP:0006530)2.59279696
68Recurrent cutaneous fungal infections (HP:0011370)2.58805737
69Chronic mucocutaneous candidiasis (HP:0002728)2.58805737
70Abnormality of the nasal mucosa (HP:0000433)2.58220057
71Recurrent bronchitis (HP:0002837)2.58181097
72Premature loss of primary teeth (HP:0006323)2.56877204
73IgA deficiency (HP:0002720)2.54850260
74Fibular hypoplasia (HP:0003038)2.53866242
75Premature rupture of membranes (HP:0001788)2.53565217
76Leukocytosis (HP:0001974)2.53077959
77Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.52278046
78Cupped ribs (HP:0000887)2.51801886
79Short middle phalanx of finger (HP:0005819)2.51368642
80Abnormal ciliary motility (HP:0012262)2.50678103
81Colitis (HP:0002583)2.49865436
82Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.47689170
83Absent epiphyses (HP:0010577)2.47689170
84Recurrent gram-negative bacterial infections (HP:0005420)2.47440733
85Loss of speech (HP:0002371)2.44632484
86Abnormality of liposaccharide metabolism (HP:0010968)2.43890197
87Abnormality of glycosphingolipid metabolism (HP:0004343)2.43890197
88Abnormality of glycolipid metabolism (HP:0010969)2.43890197
89Granulocytopenia (HP:0001913)2.43399114
90IgG deficiency (HP:0004315)2.42575407
91Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.42543794
92Short hallux (HP:0010109)2.42397837
93Short femoral neck (HP:0100864)2.41444461
94Arthropathy (HP:0003040)2.38786855
95Adrenal hypoplasia (HP:0000835)2.38717786
96Nasal polyposis (HP:0100582)2.37231834
97Delayed epiphyseal ossification (HP:0002663)2.36995159
98Gastrointestinal inflammation (HP:0004386)2.36846378
99Emphysema (HP:0002097)2.36472192
100Arterial thrombosis (HP:0004420)2.35596137
101Malnutrition (HP:0004395)2.35369497
102Inflammation of the large intestine (HP:0002037)2.35221820
103Dysostosis multiplex (HP:0000943)2.34638508
104Chronic otitis media (HP:0000389)2.33444072
105Humeroradial synostosis (HP:0003041)2.32613808
106Synostosis involving the elbow (HP:0003938)2.32613808
107Gangrene (HP:0100758)2.31916298
108Panhypogammaglobulinemia (HP:0003139)2.31222559
109Abnormality of the middle phalanges of the toes (HP:0010183)2.29653774
110Joint swelling (HP:0001386)2.29080719
111IgM deficiency (HP:0002850)2.26311982
112Chest pain (HP:0100749)2.26025327
113Gastrointestinal stroma tumor (HP:0100723)2.22792403
114Abnormality of the phalanges of the 5th finger (HP:0004213)2.22024333
115Coronal craniosynostosis (HP:0004440)2.21165271
116Anorexia (HP:0002039)2.19740499
117Eosinophilia (HP:0001880)2.19396174
118Pulmonary embolism (HP:0002204)2.16750098
119Abnormality of the pubic bones (HP:0003172)2.15844968
120Ectopic anus (HP:0004397)2.15808769
121Cellulitis (HP:0100658)2.15790208
122Segmental peripheral demyelination/remyelination (HP:0003481)2.15788957
123Severe combined immunodeficiency (HP:0004430)2.12187784
124Urticaria (HP:0001025)2.10040762
125Combined immunodeficiency (HP:0005387)2.08542808
126Increased connective tissue (HP:0009025)2.08341644
127Aplasia/Hypoplasia of the hallux (HP:0008362)2.08329348
128Bell-shaped thorax (HP:0001591)2.08249639
129Follicular hyperkeratosis (HP:0007502)2.06022924
130Abnormality of the middle phalanges of the hand (HP:0009833)2.04236482
131Mixed hearing impairment (HP:0000410)2.04005809
132Aplasia/hypoplasia of the femur (HP:0005613)2.03200026
133Abnormality of the pleura (HP:0002103)2.02812595
134Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.02598724
135Broad metatarsal (HP:0001783)2.02437798
136Neonatal hypoglycemia (HP:0001998)2.02112718
137Short middle phalanx of the 5th finger (HP:0004220)2.01631789
138Glomerulopathy (HP:0100820)2.00205828
139Abnormality of the 2nd finger (HP:0004100)2.00171175
140Abnormality of carpal bone ossification (HP:0006257)2.00105372
141Amaurosis fugax (HP:0100576)2.00067589
142Polygenic inheritance (HP:0010982)1.99859401
143Broad palm (HP:0001169)1.98638709
144Increased cerebral lipofuscin (HP:0011813)1.98501615
145Mild short stature (HP:0003502)1.98425171
146Hemiparesis (HP:0001269)1.98218473
147Abnormality of the pericardium (HP:0001697)1.98130448
148Abnormality of T cell physiology (HP:0011840)1.97202649
149Bronchomalacia (HP:0002780)1.97032140
150Metaphyseal dysplasia (HP:0100255)1.96471643
151Thin ribs (HP:0000883)1.95963653
152Lower limb amyotrophy (HP:0007210)1.95936496
153Absent eyebrow (HP:0002223)1.95908860
154Peritonitis (HP:0002586)1.95732250
155Patent foramen ovale (HP:0001655)1.94886989
156Rhizomelia (HP:0008905)1.94292459
157Parakeratosis (HP:0001036)1.93587228
158Abnormality of eosinophils (HP:0001879)1.93527547
159Aplasia of the musculature (HP:0100854)1.92795897
160Restrictive lung disease (HP:0002091)1.91781999
161Limited hip movement (HP:0008800)1.91752531
162Stomach cancer (HP:0012126)1.91136518
163Elevated erythrocyte sedimentation rate (HP:0003565)1.91131330
164Aplasia/Hypoplasia of the fibula (HP:0006492)1.90465646
165Arthralgia (HP:0002829)1.89984791
166Episodic fever (HP:0001954)1.89350365
167Tracheomalacia (HP:0002779)1.88776804
168Abnormality of the proximal phalanges of the hand (HP:0009834)1.88210629
169Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.87907528
170Midline defect of the nose (HP:0004122)1.87384954
171Abnormality of femoral epiphyses (HP:0006499)1.87384533
172Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.87384533
173Long clavicles (HP:0000890)1.87208164
174Keratitis (HP:0000491)1.86526977
175Irregular vertebral endplates (HP:0003301)1.86111828
176Acne (HP:0001061)1.86076227
177Abnormal foot bone ossification (HP:0010675)1.85487923
178Hypoplastic pelvis (HP:0008839)1.83280916
179Mildly elevated creatine phosphokinase (HP:0008180)1.83221129
180Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.81976636
181Turricephaly (HP:0000262)1.81473729
182Thin bony cortex (HP:0002753)1.80356443
183Skin ulcer (HP:0200042)1.80316055
184Septo-optic dysplasia (HP:0100842)1.79097897
185Slow saccadic eye movements (HP:0000514)1.78672529
186Dilatation of the ascending aorta (HP:0005111)1.78508133
187Flat acetabular roof (HP:0003180)1.77590387
188Abnormality of the endocardium (HP:0004306)1.77282311
189Hypoplastic scapulae (HP:0000882)1.76209170
190Aplasia/Hypoplasia of the scapulae (HP:0006713)1.76209170
191Hip contracture (HP:0003273)1.76025682
192Short clavicles (HP:0000894)1.74032052
193Abnormality of the vertebral endplates (HP:0005106)1.72482526
194Abnormality of the femoral head (HP:0003368)1.72063366
195Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.70468288
196Diaphragmatic weakness (HP:0009113)1.68424839
197Aplasia cutis congenita (HP:0001057)1.68277952
198Conical tooth (HP:0000698)1.67791442

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.91704857
2TYK23.48000281
3TIE13.27112179
4PRPF4B3.25884541
5BCR3.24545754
6TXK3.19681851
7EPHB23.17124505
8FGFR43.04714901
9IKBKE2.96236775
10TNIK2.69247259
11RIPK12.50635426
12OBSCN2.22477080
13MKNK22.20320575
14DAPK22.19699426
15MUSK2.12579206
16ERN12.12424858
17CDK82.05324759
18JAK12.03044465
19IRAK41.94567928
20TRIB31.93203988
21CSK1.92445843
22FGR1.88001960
23RIPK41.85566994
24NTRK31.85220980
25EPHA41.82520984
26ZAP701.82195373
27SIK31.72669678
28MAP3K21.69543187
29EIF2AK31.69490427
30FER1.67574025
31ERBB31.67325792
32SMG11.60033213
33IKBKB1.58572907
34PBK1.57910311
35MAP3K101.56836590
36EPHA31.52644352
37MST41.51271032
38GRK71.50308661
39ITK1.48195993
40ZAK1.47921611
41MAP2K71.46921894
42MKNK11.44219416
43EPHA21.43969789
44DDR21.43514739
45BLK1.36878708
46MAP3K111.36665771
47INSRR1.36285926
48FGFR31.35683005
49BTK1.31936757
50BMPR1B1.31900568
51FES1.30888045
52MAP2K31.30819211
53KDR1.30155286
54GRK11.29469772
55STK38L1.28398472
56MAP3K31.25876082
57LCK1.24193576
58NLK1.21558021
59TAOK11.21118322
60MAPK131.20473076
61EIF2AK21.20006389
62MET1.19339093
63YES11.18531653
64PINK11.13119822
65KIT1.08999025
66AKT31.07455008
67MAPK121.07366091
68HCK1.06963436
69PRKAA21.04904841
70MAP3K61.02173077
71HIPK21.01194143
72TESK21.00843407
73NUAK10.99932168
74CHUK0.98222185
75MATK0.98159360
76IRAK10.98025100
77JAK20.97862999
78TGFBR20.96333759
79MAP3K10.95428870
80PRKD30.93634635
81PASK0.93418988
82TYRO30.92897111
83STK30.91229877
84GRK60.91111128
85SYK0.88713841
86ADRBK10.88222576
87PLK20.87331214
88AKT20.86843306
89TNK20.86826926
90LYN0.86327676
91TEC0.85506046
92MAP3K130.85269154
93CAMK1D0.85153203
94FGFR20.84758718
95IGF1R0.84221753
96LATS20.83931723
97MAPK70.82878637
98CLK10.82360657
99STK100.78509759
100FGFR10.77597483
101MAP3K140.77299832
102STK240.77022649
103PIK3CA0.76759958
104LATS10.76201733
105CAMK1G0.76169322
106BMX0.74934574
107PIM10.74498391
108PRKCE0.73778583
109EPHB10.72753374
110ALK0.71656108
111TTN0.71325741
112TGFBR10.70932734
113NME20.70718530
114CAMK2A0.70305035
115CDK40.70300562
116NTRK20.69937117
117TBK10.68928291
118RPS6KB20.66967134
119NEK60.66854583
120CDK90.66287118
121MOS0.65366042
122IRAK30.62317467
123INSR0.60966099
124CDK120.60485401
125TRPM70.60156244
126JAK30.59611860
127MAP3K40.59502054
128MAPK110.56259816
129PAK30.55788164
130MARK20.55665968
131STK40.55367159
132KSR10.54221038
133PAK40.53946427
134SRC0.53832290
135TAOK20.53813114
136IRAK20.53599912
137WNK10.53472862
138PTK60.52674450
139PDGFRB0.52087754
140CAMK10.52049914
141MAP2K20.51743729
142PRKCD0.51025460
143PDGFRA0.49727380
144SIK10.48638502
145MYLK0.48308764
146ROCK10.47208255
147MARK30.47156260
148CDK60.46142362
149MAP2K40.45566315
150MST1R0.44852554
151RPS6KC10.44268283
152RPS6KL10.44268283
153SIK20.43766610
154PIM20.41893899
155CDC42BPA0.41854759
156CDK30.41214441
157PTK2B0.41165184
158DYRK20.41066431
159PRKD20.40753550
160PDK10.39747024
161CAMKK10.38982515
162DYRK1B0.37852931
163BRD40.36082590
164MAP3K70.36054752
165MELK0.34210623
166CSF1R0.33937013
167RPS6KA60.32784752
168MAPKAPK20.32753910
169EGFR0.31770514
170ICK0.29914869
171PRKCQ0.27984774
172TAOK30.27357002
173FYN0.26953592

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.23564404
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.85230556
3RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.72581229
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.68937618
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.65581960
6Primary immunodeficiency_Homo sapiens_hsa053402.59028976
7Osteoclast differentiation_Homo sapiens_hsa043802.54116635
8Graft-versus-host disease_Homo sapiens_hsa053322.46651198
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.44385424
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.35588544
11Measles_Homo sapiens_hsa051622.31921234
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.29788521
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.24554599
14Leishmaniasis_Homo sapiens_hsa051402.22658187
15Nicotine addiction_Homo sapiens_hsa050332.14162514
16Basal cell carcinoma_Homo sapiens_hsa052172.00797820
17Dilated cardiomyopathy_Homo sapiens_hsa054141.99269071
18Influenza A_Homo sapiens_hsa051641.97147562
19T cell receptor signaling pathway_Homo sapiens_hsa046601.93724146
20Glutamatergic synapse_Homo sapiens_hsa047241.92734364
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.91615352
22Herpes simplex infection_Homo sapiens_hsa051681.89358352
23Morphine addiction_Homo sapiens_hsa050321.88821497
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.85759482
25Protein digestion and absorption_Homo sapiens_hsa049741.82707511
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.81068657
27Focal adhesion_Homo sapiens_hsa045101.77797611
28Staphylococcus aureus infection_Homo sapiens_hsa051501.77664930
29Steroid biosynthesis_Homo sapiens_hsa001001.77289250
30Type I diabetes mellitus_Homo sapiens_hsa049401.77261576
31Acute myeloid leukemia_Homo sapiens_hsa052211.73352210
32Axon guidance_Homo sapiens_hsa043601.70714321
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.70160415
34Asthma_Homo sapiens_hsa053101.69432479
35Other glycan degradation_Homo sapiens_hsa005111.67607473
36Olfactory transduction_Homo sapiens_hsa047401.67300425
37Viral myocarditis_Homo sapiens_hsa054161.67246656
38Toxoplasmosis_Homo sapiens_hsa051451.65922794
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.65258426
40Hepatitis C_Homo sapiens_hsa051601.65037268
41Adherens junction_Homo sapiens_hsa045201.64284349
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.61202309
43Collecting duct acid secretion_Homo sapiens_hsa049661.59896721
44Antigen processing and presentation_Homo sapiens_hsa046121.59563365
45B cell receptor signaling pathway_Homo sapiens_hsa046621.58826856
46Circadian entrainment_Homo sapiens_hsa047131.56805052
47Phototransduction_Homo sapiens_hsa047441.56729287
48TGF-beta signaling pathway_Homo sapiens_hsa043501.55166611
49Tuberculosis_Homo sapiens_hsa051521.52141082
50Hedgehog signaling pathway_Homo sapiens_hsa043401.51420771
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.49773332
52Hepatitis B_Homo sapiens_hsa051611.48563219
53Cardiac muscle contraction_Homo sapiens_hsa042601.45819762
54Hematopoietic cell lineage_Homo sapiens_hsa046401.44511276
55Chemokine signaling pathway_Homo sapiens_hsa040621.44104051
56Pertussis_Homo sapiens_hsa051331.39018815
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.35665055
58HIF-1 signaling pathway_Homo sapiens_hsa040661.34192042
59Hippo signaling pathway_Homo sapiens_hsa043901.31815650
60Autoimmune thyroid disease_Homo sapiens_hsa053201.30677674
61Legionellosis_Homo sapiens_hsa051341.29966225
62Phagosome_Homo sapiens_hsa041451.28693968
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.26910293
64Rap1 signaling pathway_Homo sapiens_hsa040151.26694374
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26052363
66GABAergic synapse_Homo sapiens_hsa047271.25329609
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.24320941
68Ether lipid metabolism_Homo sapiens_hsa005651.22667964
69PI3K-Akt signaling pathway_Homo sapiens_hsa041511.21904271
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21735221
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.20494555
72Amoebiasis_Homo sapiens_hsa051461.20029461
73Apoptosis_Homo sapiens_hsa042101.15201952
74Ras signaling pathway_Homo sapiens_hsa040141.14395986
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13684515
76Pathways in cancer_Homo sapiens_hsa052001.11690634
77Epstein-Barr virus infection_Homo sapiens_hsa051691.09492029
78Shigellosis_Homo sapiens_hsa051311.09111839
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08986988
80Nitrogen metabolism_Homo sapiens_hsa009101.08666637
81Proteoglycans in cancer_Homo sapiens_hsa052051.07982425
82Wnt signaling pathway_Homo sapiens_hsa043101.07519418
83Prolactin signaling pathway_Homo sapiens_hsa049171.07078071
84Melanoma_Homo sapiens_hsa052181.06820632
85Leukocyte transendothelial migration_Homo sapiens_hsa046701.05608149
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04523946
87Small cell lung cancer_Homo sapiens_hsa052221.04437837
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02987198
89cAMP signaling pathway_Homo sapiens_hsa040241.02323915
90Salmonella infection_Homo sapiens_hsa051321.01547600
91Cholinergic synapse_Homo sapiens_hsa047251.01422520
92HTLV-I infection_Homo sapiens_hsa051660.98050548
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97594621
94Vibrio cholerae infection_Homo sapiens_hsa051100.96161858
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95372236
96Chronic myeloid leukemia_Homo sapiens_hsa052200.94767330
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91489145
98Melanogenesis_Homo sapiens_hsa049160.90864638
99VEGF signaling pathway_Homo sapiens_hsa043700.90107124
100Propanoate metabolism_Homo sapiens_hsa006400.89736455
101Ovarian steroidogenesis_Homo sapiens_hsa049130.88988959
102Calcium signaling pathway_Homo sapiens_hsa040200.88785290
103Serotonergic synapse_Homo sapiens_hsa047260.88422387
104Pancreatic cancer_Homo sapiens_hsa052120.87409260
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85192683
106Notch signaling pathway_Homo sapiens_hsa043300.85052981
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83215182
108Salivary secretion_Homo sapiens_hsa049700.80780185
109Lysosome_Homo sapiens_hsa041420.80474453
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.80335909
111Viral carcinogenesis_Homo sapiens_hsa052030.77941858
112Prion diseases_Homo sapiens_hsa050200.75364737
113Taste transduction_Homo sapiens_hsa047420.75211762
114Sphingolipid metabolism_Homo sapiens_hsa006000.74054012
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.73574249
116Malaria_Homo sapiens_hsa051440.73303880
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.71449002
118Vitamin digestion and absorption_Homo sapiens_hsa049770.68968186
119Rheumatoid arthritis_Homo sapiens_hsa053230.67912767
120African trypanosomiasis_Homo sapiens_hsa051430.67874908
121Bile secretion_Homo sapiens_hsa049760.66896192
122Arginine and proline metabolism_Homo sapiens_hsa003300.66884727
123Chemical carcinogenesis_Homo sapiens_hsa052040.66383441
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65848699
125Complement and coagulation cascades_Homo sapiens_hsa046100.64113963
126Cocaine addiction_Homo sapiens_hsa050300.63984524
127TNF signaling pathway_Homo sapiens_hsa046680.63732408
128Oxidative phosphorylation_Homo sapiens_hsa001900.58959206
129Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58461268
130Non-small cell lung cancer_Homo sapiens_hsa052230.57092554
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.55828891
132Bladder cancer_Homo sapiens_hsa052190.54085039
133FoxO signaling pathway_Homo sapiens_hsa040680.52704777
134Insulin secretion_Homo sapiens_hsa049110.51957519
135Colorectal cancer_Homo sapiens_hsa052100.51826809
136Platelet activation_Homo sapiens_hsa046110.51744039
137Renal cell carcinoma_Homo sapiens_hsa052110.50601897
138Fatty acid biosynthesis_Homo sapiens_hsa000610.50392900
139Prostate cancer_Homo sapiens_hsa052150.49629593
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49621540
141Gap junction_Homo sapiens_hsa045400.48988149
142Allograft rejection_Homo sapiens_hsa053300.48869028
143Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47638243
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.46279792
145beta-Alanine metabolism_Homo sapiens_hsa004100.45808789
146Endometrial cancer_Homo sapiens_hsa052130.45162620
147Insulin resistance_Homo sapiens_hsa049310.45074688
148Arachidonic acid metabolism_Homo sapiens_hsa005900.44627139
149MAPK signaling pathway_Homo sapiens_hsa040100.44539040
150Endocytosis_Homo sapiens_hsa041440.44147781
151Choline metabolism in cancer_Homo sapiens_hsa052310.44144159
152Sulfur metabolism_Homo sapiens_hsa009200.43892568
153Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42577393
154Tight junction_Homo sapiens_hsa045300.42420432
155Gastric acid secretion_Homo sapiens_hsa049710.42370607
156Mineral absorption_Homo sapiens_hsa049780.42202809
157Dorso-ventral axis formation_Homo sapiens_hsa043200.41611480
158GnRH signaling pathway_Homo sapiens_hsa049120.41592260
159Thyroid cancer_Homo sapiens_hsa052160.40975851
160Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38808519
161Phospholipase D signaling pathway_Homo sapiens_hsa040720.38737348
162Caffeine metabolism_Homo sapiens_hsa002320.38400031
163MicroRNAs in cancer_Homo sapiens_hsa052060.38344940
164Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36588874
165Type II diabetes mellitus_Homo sapiens_hsa049300.27898077
166mTOR signaling pathway_Homo sapiens_hsa041500.26043466
167Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24995369
168ErbB signaling pathway_Homo sapiens_hsa040120.22439362
169Galactose metabolism_Homo sapiens_hsa000520.22150102
170SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20279678
171Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19516993

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