HAS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1anterior/posterior axis specification, embryo (GO:0008595)6.52780966
2chondrocyte proliferation (GO:0035988)6.04700281
3primitive streak formation (GO:0090009)5.94945144
4collagen fibril organization (GO:0030199)5.54100910
5sequestering of extracellular ligand from receptor (GO:0035581)5.44080427
6negative regulation of axon guidance (GO:1902668)5.33300160
7bone trabecula formation (GO:0060346)4.81308663
8endoderm formation (GO:0001706)4.78302407
9regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901214.77615664
10regulation of mesoderm development (GO:2000380)4.65497176
11mesenchymal-epithelial cell signaling (GO:0060638)4.62141125
12anterior/posterior axis specification (GO:0009948)4.34588520
13endodermal cell differentiation (GO:0035987)4.25950129
14neuron projection extension involved in neuron projection guidance (GO:1902284)4.23640787
15axon extension involved in axon guidance (GO:0048846)4.23640787
16mitotic metaphase plate congression (GO:0007080)4.16628088
17regulation of axon extension involved in axon guidance (GO:0048841)4.13260164
18metanephric mesenchyme development (GO:0072075)4.12989631
19wound healing, spreading of epidermal cells (GO:0035313)4.07009550
20negative regulation of chondrocyte differentiation (GO:0032331)4.05797502
21protein heterotrimerization (GO:0070208)4.01005559
22cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.00150435
23regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.98925702
24midgut development (GO:0007494)3.97131744
25planar cell polarity pathway involved in neural tube closure (GO:0090179)3.96147903
26chondrocyte development (GO:0002063)3.93469230
27craniofacial suture morphogenesis (GO:0097094)3.92883846
28regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.89362972
29hippo signaling (GO:0035329)3.86841917
30paraxial mesoderm development (GO:0048339)3.85166300
31kidney mesenchyme development (GO:0072074)3.78300292
32cell surface receptor signaling pathway involved in heart development (GO:0061311)3.78269052
33regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.77094790
34negative regulation of activin receptor signaling pathway (GO:0032926)3.75344405
35regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393)3.73883202
36cell migration involved in gastrulation (GO:0042074)3.71541374
37ventricular cardiac muscle cell development (GO:0055015)3.70993218
38pericardium development (GO:0060039)3.70701515
39CENP-A containing nucleosome assembly (GO:0034080)3.68768224
40uterus development (GO:0060065)3.66464691
41dorsal/ventral axis specification (GO:0009950)3.66188982
42outer ear morphogenesis (GO:0042473)3.65633073
43G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.65363953
44response to BMP (GO:0071772)3.62590708
45cellular response to BMP stimulus (GO:0071773)3.62590708
46female gonad development (GO:0008585)3.59626457
47regulation of axon guidance (GO:1902667)3.58426388
48metaphase plate congression (GO:0051310)3.58414173
49embryonic foregut morphogenesis (GO:0048617)3.57060948
50chromatin remodeling at centromere (GO:0031055)3.56605784
51embryonic cranial skeleton morphogenesis (GO:0048701)3.55848534
52signal transduction involved in regulation of gene expression (GO:0023019)3.49531716
53kinetochore organization (GO:0051383)3.49169780
54cell adhesion mediated by integrin (GO:0033627)3.48136968
55negative regulation of fatty acid transport (GO:2000192)3.47479624
56embryonic skeletal joint morphogenesis (GO:0060272)3.45631890
57embryonic axis specification (GO:0000578)3.44922303
58mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.43746865
59extracellular regulation of signal transduction (GO:1900115)3.42126113
60extracellular negative regulation of signal transduction (GO:1900116)3.42126113
61protein localization to kinetochore (GO:0034501)3.41911328
62skin morphogenesis (GO:0043589)3.41492149
63middle ear morphogenesis (GO:0042474)3.41453357
64cranial suture morphogenesis (GO:0060363)3.41166035
65positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)3.40794117
66negative regulation of cartilage development (GO:0061037)3.38433236
67negative regulation of cardiac muscle tissue development (GO:0055026)3.36844500
68mesodermal cell differentiation (GO:0048333)3.34477160
69negative regulation of embryonic development (GO:0045992)3.34136349
70organ formation (GO:0048645)3.33028844
71regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.31817783
72negative regulation of hormone biosynthetic process (GO:0032353)3.30652526
73endocardial cushion development (GO:0003197)3.30248883
74mesenchymal cell proliferation (GO:0010463)3.28883064
75regulation of cardioblast differentiation (GO:0051890)3.27332548
76dermatan sulfate biosynthetic process (GO:0030208)3.25032741
77gastrulation (GO:0007369)3.24485181
78positive regulation of cardiac muscle tissue development (GO:0055025)3.23872072
79limb bud formation (GO:0060174)3.22400912
80negative regulation of stem cell proliferation (GO:2000647)3.20779066
81cellular response to vitamin D (GO:0071305)3.18759111
82regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.18590392
83epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.17282449
84body morphogenesis (GO:0010171)3.16422207
85histone exchange (GO:0043486)3.15990046
86negative regulation of BMP signaling pathway (GO:0030514)3.15322032
87peptidyl-proline hydroxylation (GO:0019511)3.14565117
88wound healing, spreading of cells (GO:0044319)3.14429368
89notochord development (GO:0030903)3.13372319
90regulation of heart morphogenesis (GO:2000826)3.12557493
91collagen metabolic process (GO:0032963)3.12391382
92establishment of chromosome localization (GO:0051303)3.11904272
93positive regulation of epithelial to mesenchymal transition (GO:0010718)3.11778732
94cell proliferation involved in metanephros development (GO:0072203)3.11513269
95positive regulation of SMAD protein import into nucleus (GO:0060391)3.11366682
96kinetochore assembly (GO:0051382)3.10178003
97vagina development (GO:0060068)3.08094280
98regulation of cardiac muscle tissue development (GO:0055024)3.07176703
99regulation of cardiac muscle cell differentiation (GO:2000725)3.05791116
100DNA double-strand break processing (GO:0000729)3.05639664
101female genitalia development (GO:0030540)3.05573826
102positive regulation of cardiac muscle cell proliferation (GO:0060045)3.04935199
103regulation of cartilage development (GO:0061035)3.04848815
104regulation of centriole replication (GO:0046599)3.04321754
105mitotic G2/M transition checkpoint (GO:0044818)3.02186000
106collagen catabolic process (GO:0030574)3.01868385
107regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.01820777
108negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.01732409
109embryonic body morphogenesis (GO:0010172)3.01344668
110proteasome assembly (GO:0043248)3.01171530
111neural crest cell development (GO:0014032)3.00898193
112type B pancreatic cell development (GO:0003323)3.00795647
113cell proliferation involved in kidney development (GO:0072111)3.00128108
114endothelial cell proliferation (GO:0001935)3.00101774
115positive regulation of p38MAPK cascade (GO:1900745)2.99025868
116* epithelial to mesenchymal transition (GO:0001837)2.98717045
117regulation of activin receptor signaling pathway (GO:0032925)2.98709339
118positive regulation of cardiac muscle cell differentiation (GO:2000727)2.97734166
119positive regulation of macrophage activation (GO:0043032)2.96623342
120positive regulation of endothelial cell apoptotic process (GO:2000353)2.96490880
121cartilage morphogenesis (GO:0060536)2.93937231
122negative regulation of DNA repair (GO:0045738)2.93882702
123positive regulation of cartilage development (GO:0061036)2.91809631
124Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.91467914
125cochlea morphogenesis (GO:0090103)2.90432616
126positive regulation of mesenchymal cell proliferation (GO:0002053)2.90355207
127mesenchyme development (GO:0060485)2.89931689
128regulation of chondrocyte differentiation (GO:0032330)2.88290296
129mesenchyme morphogenesis (GO:0072132)2.87991995
130dermatan sulfate metabolic process (GO:0030205)2.87774794
131negative regulation of axon extension involved in axon guidance (GO:0048843)2.87653442
132regulation of gastrulation (GO:0010470)2.87614682
133positive regulation of protein autophosphorylation (GO:0031954)2.87300738
134multicellular organismal macromolecule metabolic process (GO:0044259)2.85672819
135negative regulation of catenin import into nucleus (GO:0035414)2.85621223
136regulation of establishment of planar polarity (GO:0090175)2.84421671
137lateral sprouting from an epithelium (GO:0060601)2.84413378
138regulation of cardiac muscle cell proliferation (GO:0060043)2.84214139
139positive regulation of T cell chemotaxis (GO:0010820)2.82252997
140regulation of T cell chemotaxis (GO:0010819)2.82252997
141negative chemotaxis (GO:0050919)2.81902544
142UDP-N-acetylglucosamine metabolic process (GO:0006047)2.81149452
143protein localization to cell surface (GO:0034394)2.81141554
144polarized epithelial cell differentiation (GO:0030859)2.80839953
145regulation of tight junction assembly (GO:2000810)2.80520003
146branch elongation of an epithelium (GO:0060602)2.79785888
147regulation of mesenchymal cell proliferation (GO:0010464)2.79300692
148cell migration involved in heart development (GO:0060973)2.79210850
149protein hydroxylation (GO:0018126)2.79090529
150regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.78604178
151cellular response to vitamin (GO:0071295)2.78407955
152regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.76984115
153negative regulation of hormone metabolic process (GO:0032351)2.76821407
154regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.76214246
155DNA replication-independent nucleosome assembly (GO:0006336)2.75798261
156DNA replication-independent nucleosome organization (GO:0034724)2.75798261
157organ induction (GO:0001759)2.74944774
158positive regulation of astrocyte differentiation (GO:0048711)2.73672987
159purine nucleobase biosynthetic process (GO:0009113)2.72843916
160mesoderm formation (GO:0001707)2.71858517
161substrate-dependent cell migration (GO:0006929)2.71223463
162protein localization to chromosome, centromeric region (GO:0071459)2.69665002
163lung morphogenesis (GO:0060425)2.69484444
164multicellular organismal catabolic process (GO:0044243)2.69209416
165regulation of glucocorticoid metabolic process (GO:0031943)2.69171841
166mesonephric tubule development (GO:0072164)2.68656339
167multicellular organismal metabolic process (GO:0044236)2.67961439
168mitotic G2 DNA damage checkpoint (GO:0007095)2.66019432
169positive regulation of cardiac muscle tissue growth (GO:0055023)2.65752899
170ureteric bud development (GO:0001657)2.63942584
171negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.63690420
172myoblast migration (GO:0051451)2.63552845
173extracellular matrix disassembly (GO:0022617)2.63323960
174cell migration involved in sprouting angiogenesis (GO:0002042)2.63035390
175mesenchymal cell development (GO:0014031)2.62336978
176regulation of transforming growth factor beta2 production (GO:0032909)2.62139221
177axis specification (GO:0009798)2.61286340
178ganglion development (GO:0061548)2.61068822
179SMAD protein signal transduction (GO:0060395)2.60395312
180lymphangiogenesis (GO:0001946)2.59217536
181replication fork processing (GO:0031297)2.55728183

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.46819212
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.93972827
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.50953519
4WT1_19549856_ChIP-ChIP_CCG9911_Human3.36009817
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.30874381
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.21153595
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.97661658
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.96326976
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.95522211
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.88408320
11* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.81907701
12HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.67587509
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.55132187
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.46317868
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.44805894
16* BRD4_25478319_ChIP-Seq_HGPS_Human2.42246351
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.40114900
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.39104995
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.38228912
20RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.33592945
21HIF1A_21447827_ChIP-Seq_MCF-7_Human2.30187151
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27099032
23CJUN_26792858_Chip-Seq_BT549_Human2.26838275
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19873374
25* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.13346947
26CLOCK_20551151_ChIP-Seq_293T_Human2.04421214
27ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.03677076
28* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.01839988
29P300_19829295_ChIP-Seq_ESCs_Human1.99670952
30SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.96609954
31SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.96609954
32TP53_18474530_ChIP-ChIP_U2OS_Human1.94298074
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.93985550
34* SMAD3_21741376_ChIP-Seq_EPCs_Human1.89507798
35TP53_20018659_ChIP-ChIP_R1E_Mouse1.88232671
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.87908172
37CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.86743247
38* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.83653801
39E2F7_22180533_ChIP-Seq_HELA_Human1.82991927
40VDR_22108803_ChIP-Seq_LS180_Human1.82671227
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.80633544
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.78172240
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.76368631
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.75823553
45KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.75810684
46KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.75810684
47KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.75810684
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75035629
49AR_21909140_ChIP-Seq_LNCAP_Human1.74150987
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.72955622
51SMAD3_21741376_ChIP-Seq_HESCs_Human1.72180919
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.71313877
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.71200347
54TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.70314004
55* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.68668559
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67407495
57* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.66669573
58* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.66669573
59* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66154065
60TP53_16413492_ChIP-PET_HCT116_Human1.66034753
61* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64270883
62TAF15_26573619_Chip-Seq_HEK293_Human1.60911484
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58448002
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.58431866
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58005091
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50002434
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48966251
68UBF1/2_26484160_Chip-Seq_HMECs_Human1.48963585
69NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.48527974
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44651423
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.43738814
72ZNF274_21170338_ChIP-Seq_K562_Hela1.42908418
73RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.42363865
74SALL4_18804426_ChIP-ChIP_XEN_Mouse1.41285588
75* ISL1_27105846_Chip-Seq_CPCs_Mouse1.38387195
76GBX2_23144817_ChIP-Seq_PC3_Human1.36527111
77* EOMES_21245162_ChIP-Seq_HESCs_Human1.35369293
78SMAD4_21741376_ChIP-Seq_EPCs_Human1.35254261
79* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35114489
80* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32454560
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31576095
82* BCAT_22108803_ChIP-Seq_LS180_Human1.31003559
83TCF4_18268006_ChIP-ChIP_LS174T_Human1.30935033
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30288833
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30219541
86* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29989262
87SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29789748
88* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27956763
89* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27956763
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27276917
91* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26660011
92SMAD4_21799915_ChIP-Seq_A2780_Human1.26287242
93SMAD4_21741376_ChIP-Seq_HESCs_Human1.25231706
94EZH2_27304074_Chip-Seq_ESCs_Mouse1.24899243
95* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.23609575
96* NANOG_16153702_ChIP-ChIP_HESCs_Human1.23238321
97ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.23176716
98E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20714288
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20223510
100ESR1_21235772_ChIP-Seq_MCF-7_Human1.19825555
101ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.17025854
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.16372353
103EWS_26573619_Chip-Seq_HEK293_Human1.15567765
104SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15473609
105SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15386465
106PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15229320
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14966745
108* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.14380557
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13911728
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13480120
111TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13296416
112* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13072340
113FUS_26573619_Chip-Seq_HEK293_Human1.12762081
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12115848
115CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11915153
116JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11548832
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10930913
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10726405
119JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09522454
120FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.09374036
121CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08370218
122E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08321742
123SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07848425
124SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07577608
125ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06760555
126MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.06405520
127SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06164968
128CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04937766
129TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04574951
130CRX_20693478_ChIP-Seq_RETINA_Mouse1.04350736
131NFE2_27457419_Chip-Seq_LIVER_Mouse1.04218407
132TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04059944
133SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.03598430
134EST1_17652178_ChIP-ChIP_JURKAT_Human1.02889648
135* SOX2_20726797_ChIP-Seq_SW620_Human1.01850142
136* ELK1_22589737_ChIP-Seq_MCF10A_Human1.01358757
137* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01229506
138ELK1_19687146_ChIP-ChIP_HELA_Human1.01124857
139* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99878523
140FLI1_21867929_ChIP-Seq_TH2_Mouse0.98831890
141PIAS1_25552417_ChIP-Seq_VCAP_Human0.98826647
142* TCF4_22108803_ChIP-Seq_LS180_Human0.97726072
143* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97224191
144KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97135449
145EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97067504
146TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96656977
147GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96485545
148TP53_23651856_ChIP-Seq_MEFs_Mouse0.96463421
149FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95722591
150KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94637295
151* SA1_22415368_ChIP-Seq_MEFs_Mouse0.94403167
152* RING1B_27294783_Chip-Seq_NPCs_Mouse0.93910346
153NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93560396
154* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93060526
155JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93001107
156NFI_21473784_ChIP-Seq_ESCs_Mouse0.92475745
157SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90958658
158MYC_18555785_ChIP-Seq_MESCs_Mouse0.90404315
159SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90121114
160TP53_22127205_ChIP-Seq_IMR90_Human0.89255689

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.95394580
2MP0003890_abnormal_embryonic-extraembry5.07850941
3MP0005503_abnormal_tendon_morphology4.48365460
4MP0010030_abnormal_orbit_morphology3.77260521
5MP0005275_abnormal_skin_tensile3.76164313
6MP0003705_abnormal_hypodermis_morpholog3.20859178
7MP0003279_aneurysm2.96822233
8MP0009053_abnormal_anal_canal2.69352991
9MP0009384_cardiac_valve_regurgitation2.66159983
10MP0009250_abnormal_appendicular_skeleto2.64217727
11MP0003385_abnormal_body_wall2.57183788
12MP0003119_abnormal_digestive_system2.42395679
13MP0004272_abnormal_basement_membrane2.39967641
14MP0002102_abnormal_ear_morphology2.32231565
15MP0010352_gastrointestinal_tract_polyps2.27740750
16MP0003195_calcinosis2.14207605
17MP0005508_abnormal_skeleton_morphology2.13629647
18MP0005623_abnormal_meninges_morphology2.11981698
19MP0005257_abnormal_intraocular_pressure2.06801226
20MP0000049_abnormal_middle_ear1.97765841
21MP0003942_abnormal_urinary_system1.93471062
22MP0003755_abnormal_palate_morphology1.89925520
23MP0003950_abnormal_plasma_membrane1.89794913
24MP0003122_maternal_imprinting1.88745569
25MP0002282_abnormal_trachea_morphology1.85270615
26MP0000733_abnormal_muscle_development1.79467759
27MP0001299_abnormal_eye_distance/1.77552656
28MP0003566_abnormal_cell_adhesion1.77385700
29* MP0003937_abnormal_limbs/digits/tail_de1.76075519
30MP0001958_emphysema1.75277404
31MP0003941_abnormal_skin_development1.68972217
32MP0000762_abnormal_tongue_morphology1.68314114
33MP0005023_abnormal_wound_healing1.65972179
34MP0002249_abnormal_larynx_morphology1.64420250
35MP0000534_abnormal_ureter_morphology1.62606042
36MP0010094_abnormal_chromosome_stability1.59321405
37* MP0002932_abnormal_joint_morphology1.58729048
38MP0004134_abnormal_chest_morphology1.56959827
39MP0004957_abnormal_blastocyst_morpholog1.56519532
40MP0000537_abnormal_urethra_morphology1.54819912
41MP0004215_abnormal_myocardial_fiber1.54491520
42MP0000428_abnormal_craniofacial_morphol1.53965921
43MP0002060_abnormal_skin_morphology1.53011933
44* MP0000163_abnormal_cartilage_morphology1.51597034
45MP0002896_abnormal_bone_mineralization1.51128279
46MP0002127_abnormal_cardiovascular_syste1.48952520
47MP0003935_abnormal_craniofacial_develop1.48326746
48MP0003123_paternal_imprinting1.48114409
49MP0006054_spinal_hemorrhage1.46317442
50MP0008775_abnormal_heart_ventricle1.45995534
51MP0002233_abnormal_nose_morphology1.44516564
52MP0004084_abnormal_cardiac_muscle1.43152913
53MP0003567_abnormal_fetal_cardiomyocyte1.40541544
54MP0000432_abnormal_head_morphology1.39685513
55MP0003091_abnormal_cell_migration1.39442161
56MP0002116_abnormal_craniofacial_bone1.34929057
57* MP0002115_abnormal_skeleton_extremities1.33552453
58MP0002938_white_spotting1.33543395
59MP0004133_heterotaxia1.33272981
60MP0000516_abnormal_urinary_system1.32602422
61MP0005367_renal/urinary_system_phenotyp1.32602422
62* MP0005380_embryogenesis_phenotype1.32021486
63* MP0001672_abnormal_embryogenesis/_devel1.32021486
64* MP0002109_abnormal_limb_morphology1.31856166
65MP0002108_abnormal_muscle_morphology1.30628951
66MP0008057_abnormal_DNA_replication1.29927958
67* MP0002113_abnormal_skeleton_development1.29308225
68MP0003011_delayed_dark_adaptation1.25831293
69MP0000749_muscle_degeneration1.25790340
70MP0003121_genomic_imprinting1.24719629
71MP0003115_abnormal_respiratory_system1.24509404
72MP0001348_abnormal_lacrimal_gland1.21927428
73MP0002111_abnormal_tail_morphology1.20417239
74MP0010368_abnormal_lymphatic_system1.17133439
75MP0001243_abnormal_dermal_layer1.16134270
76MP0000767_abnormal_smooth_muscle1.15301193
77MP0001346_abnormal_lacrimal_gland1.15124829
78MP0000538_abnormal_urinary_bladder1.15053959
79MP0005390_skeleton_phenotype1.14187276
80MP0001177_atelectasis1.12322316
81MP0005248_abnormal_Harderian_gland1.12042314
82MP0000566_synostosis1.11617734
83MP0003077_abnormal_cell_cycle1.11189778
84MP0005076_abnormal_cell_differentiation1.10867559
85MP0002177_abnormal_outer_ear1.09121228
86MP0004145_abnormal_muscle_electrophysio1.08166341
87MP0006072_abnormal_retinal_apoptosis1.07790231
88MP0001730_embryonic_growth_arrest1.06829460
89MP0002295_abnormal_pulmonary_circulatio1.06735795
90MP0001542_abnormal_bone_strength1.05210380
91MP0000678_abnormal_parathyroid_gland1.03542006
92MP0008058_abnormal_DNA_repair1.02462651
93MP0002114_abnormal_axial_skeleton1.02223664
94MP0009697_abnormal_copulation1.02022681
95MP0002160_abnormal_reproductive_system1.01574746
96MP0001293_anophthalmia0.97175682
97MP0001697_abnormal_embryo_size0.96374971
98MP0000462_abnormal_digestive_system0.94372104
99* MP0002086_abnormal_extraembryonic_tissu0.93417914
100MP0005187_abnormal_penis_morphology0.92984175
101MP0004197_abnormal_fetal_growth/weight/0.91859175
102MP0001340_abnormal_eyelid_morphology0.91027287
103MP0008007_abnormal_cellular_replicative0.90993133
104MP0002933_joint_inflammation0.88473392
105* MP0002925_abnormal_cardiovascular_devel0.88468403
106MP0005171_absent_coat_pigmentation0.87683840
107MP0003943_abnormal_hepatobiliary_system0.87657499
108MP0005394_taste/olfaction_phenotype0.86139671
109MP0005499_abnormal_olfactory_system0.86139671
110MP0002877_abnormal_melanocyte_morpholog0.85398222
111MP0003936_abnormal_reproductive_system0.82946343
112MP0002697_abnormal_eye_size0.81554512
113MP0001879_abnormal_lymphatic_vessel0.80774186
114* MP0002085_abnormal_embryonic_tissue0.80603424
115MP0008004_abnormal_stomach_pH0.80200956
116* MP0001614_abnormal_blood_vessel0.79862262
117MP0000750_abnormal_muscle_regeneration0.77034419
118MP0003283_abnormal_digestive_organ0.76604329
119* MP0002084_abnormal_developmental_patter0.76331114
120MP0001175_abnormal_lung_morphology0.76209367
121MP0001286_abnormal_eye_development0.76157288
122MP0008932_abnormal_embryonic_tissue0.75236275
123MP0002751_abnormal_autonomic_nervous0.75131669
124MP0002254_reproductive_system_inflammat0.74669035
125MP0002234_abnormal_pharynx_morphology0.74653085
126MP0002128_abnormal_blood_circulation0.72767708
127MP0002089_abnormal_postnatal_growth/wei0.72393398
128MP0005197_abnormal_uvea_morphology0.72252722
129MP0000372_irregular_coat_pigmentation0.71608044
130MP0002092_abnormal_eye_morphology0.69357058
131MP0003795_abnormal_bone_structure0.68489894
132MP0001270_distended_abdomen0.68309793
133MP0001915_intracranial_hemorrhage0.66169754
134MP0009703_decreased_birth_body0.65880987
135MP0006138_congestive_heart_failure0.65317165
136MP0003938_abnormal_ear_development0.65276414
137MP0000350_abnormal_cell_proliferation0.63545935
138* MP0002088_abnormal_embryonic_growth/wei0.60974903
139* MP0003984_embryonic_growth_retardation0.60155863

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.59034597
2Protrusio acetabuli (HP:0003179)6.52337467
3Abnormality of the fetal cardiovascular system (HP:0010948)5.62910300
4Abnormal umbilical cord blood vessels (HP:0011403)5.62910300
5Single umbilical artery (HP:0001195)5.62910300
6Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)4.86399978
7Abnormality of the middle phalanx of the 5th finger (HP:0004219)4.79595017
8Abnormality of the umbilical cord (HP:0010881)4.44336147
9Abnormality of the phalanges of the 5th finger (HP:0004213)4.43445315
10Shallow orbits (HP:0000586)4.15014261
11Aortic dissection (HP:0002647)3.99675647
12Bifid tongue (HP:0010297)3.99192904
13Atrophic scars (HP:0001075)3.98647446
14Soft skin (HP:0000977)3.98427321
15Hypoplastic pelvis (HP:0008839)3.62540329
16Neonatal short-limb short stature (HP:0008921)3.55493369
17Abnormality of dentin (HP:0010299)3.55406308
18Peritonitis (HP:0002586)3.53807260
19Myelomeningocele (HP:0002475)3.48839670
20Short 4th metacarpal (HP:0010044)3.45758655
21Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.45758655
22Fragile skin (HP:0001030)3.28298001
23Ankle contracture (HP:0006466)3.10687464
24Abnormalities of placenta or umbilical cord (HP:0001194)3.10166718
25Dilatation of the ascending aorta (HP:0005111)3.08521082
26Genu recurvatum (HP:0002816)3.06961217
27Aortic aneurysm (HP:0004942)2.98950515
28Bladder diverticulum (HP:0000015)2.98208555
29Short hallux (HP:0010109)2.94941817
30Follicular hyperkeratosis (HP:0007502)2.89680107
31Syringomyelia (HP:0003396)2.83568218
32Spinal cord lesions (HP:0100561)2.83568218
33Abnormal pancreas size (HP:0012094)2.83502085
34Abnormal lung lobation (HP:0002101)2.83193257
35Wormian bones (HP:0002645)2.80412088
36Mesomelia (HP:0003027)2.79979324
37Cervical subluxation (HP:0003308)2.78752191
38Abnormality of the middle phalanges of the toes (HP:0010183)2.75150271
39Abnormal vertebral ossification (HP:0100569)2.73395218
40Microglossia (HP:0000171)2.69684776
41Aplasia/Hypoplasia of the hallux (HP:0008362)2.66977360
42Mitral valve prolapse (HP:0001634)2.66592730
43Blue sclerae (HP:0000592)2.65786662
44Short humerus (HP:0005792)2.65403259
45Aplasia/hypoplasia of the humerus (HP:0006507)2.63555631
46Coronal craniosynostosis (HP:0004440)2.59157732
47Abnormality of the lumbar spine (HP:0100712)2.59140870
48Septo-optic dysplasia (HP:0100842)2.59050408
49Abnormality of the 4th metacarpal (HP:0010012)2.59007107
50Biconcave vertebral bodies (HP:0004586)2.58916149
51Volvulus (HP:0002580)2.57607138
52Vertebral compression fractures (HP:0002953)2.53459339
53Broad metatarsal (HP:0001783)2.52493229
54Hypoplastic labia majora (HP:0000059)2.49545605
55Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.48954185
56Abnormality of abdominal situs (HP:0011620)2.46869728
57Abdominal situs inversus (HP:0003363)2.46869728
58Cerebral aneurysm (HP:0004944)2.46212009
59Short middle phalanx of finger (HP:0005819)2.39995837
60Broad long bones (HP:0005622)2.37320116
61Spinal rigidity (HP:0003306)2.36583808
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.34064771
63Wide anterior fontanel (HP:0000260)2.33099337
64Small hand (HP:0200055)2.31935980
65Short middle phalanx of the 5th finger (HP:0004220)2.31567788
66Abnormality of the right ventricle (HP:0001707)2.29545740
67Increased density of long bones (HP:0006392)2.29125692
68Embryonal renal neoplasm (HP:0011794)2.27280862
69Abnormality of the middle phalanges of the hand (HP:0009833)2.26668556
70Abnormality of the labia majora (HP:0012881)2.26247729
71Overgrowth (HP:0001548)2.26047038
72Type 1 muscle fiber predominance (HP:0003803)2.23735474
73Disproportionate short-trunk short stature (HP:0003521)2.23512361
74Wrist flexion contracture (HP:0001239)2.22624670
75Missing ribs (HP:0000921)2.22447981
76Asplenia (HP:0001746)2.20853257
77Proximal placement of thumb (HP:0009623)2.19823630
78Intestinal atresia (HP:0011100)2.18787833
79Elbow flexion contracture (HP:0002987)2.18201121
80Infantile muscular hypotonia (HP:0008947)2.17771573
81Deviation of the thumb (HP:0009603)2.17483753
82Deviation of the hallux (HP:0010051)2.17270303
83Aplasia/Hypoplasia of the spleen (HP:0010451)2.17025814
84Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.13923233
85Bowel diverticulosis (HP:0005222)2.13480635
86Preaxial foot polydactyly (HP:0001841)2.13335039
87Supernumerary spleens (HP:0009799)2.13128715
88Meckel diverticulum (HP:0002245)2.11981692
89Mild short stature (HP:0003502)2.11564503
90Short 1st metacarpal (HP:0010034)2.11469313
91Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.11469313
92Short tibia (HP:0005736)2.09800470
93Abnormality of the acetabulum (HP:0003170)2.09788538
94Broad ribs (HP:0000885)2.09062888
95Hyperextensible skin (HP:0000974)2.08092642
96Hypoplastic ischia (HP:0003175)2.07235366
97Hallux valgus (HP:0001822)2.06462780
98Congenital malformation of the right heart (HP:0011723)2.06207791
99Double outlet right ventricle (HP:0001719)2.06207791
100Vitreoretinal degeneration (HP:0000655)2.06130684
101Broad phalanx (HP:0006009)2.05588837
102Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.05568006
103Bell-shaped thorax (HP:0001591)2.02175019
104Abnormal auditory evoked potentials (HP:0006958)2.01634935
105Morphological abnormality of the middle ear (HP:0008609)2.00470220
106Abnormality of the ileum (HP:0001549)2.00022225
107Aplasia/Hypoplasia of the tibia (HP:0005772)1.99902748
108Joint laxity (HP:0001388)1.99256496
109Broad thumb (HP:0011304)1.99115257
110Increased connective tissue (HP:0009025)1.98801512
111Abnormal delivery (HP:0001787)1.98734618
112Epiphyseal dysplasia (HP:0002656)1.98573105
113Abnormality of chromosome stability (HP:0003220)1.96241387
114Abnormality of the peritoneum (HP:0002585)1.95793547
115Broad toe (HP:0001837)1.95781453
116Short nail (HP:0001799)1.94460652
117Limited elbow extension (HP:0001377)1.94161470
118Tibial bowing (HP:0002982)1.94013851
119Small intestinal stenosis (HP:0012848)1.93888957
120Duodenal stenosis (HP:0100867)1.93888957
121Adrenal hypoplasia (HP:0000835)1.93876574
122Osteoarthritis (HP:0002758)1.93026682
123Renal duplication (HP:0000075)1.92904515
124Broad phalanges of the hand (HP:0009768)1.90040384
125Natal tooth (HP:0000695)1.89646636
126Patent foramen ovale (HP:0001655)1.88203630
127Ulnar bowing (HP:0003031)1.87683952
128Ectopic anus (HP:0004397)1.87405080
129Labial hypoplasia (HP:0000066)1.86969170
130Abnormality of the 2nd finger (HP:0004100)1.86707186
131Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.86084656
132Abnormality of the duodenum (HP:0002246)1.85572954
133Periauricular skin pits (HP:0100277)1.85355273
134Preauricular pit (HP:0004467)1.85355273
135Ectopia lentis (HP:0001083)1.84638684
136Broad finger (HP:0001500)1.84531490
137Vascular tortuosity (HP:0004948)1.82471188
138Enlarged kidneys (HP:0000105)1.82269156
139Hypoplastic female external genitalia (HP:0012815)1.82055877
140Short 5th finger (HP:0009237)1.81765157
141Abnormality of the distal phalanx of the thumb (HP:0009617)1.80821386
142Asymmetry of the thorax (HP:0001555)1.80517861
143Abnormality of the 1st metacarpal (HP:0010009)1.80068825
144Absent radius (HP:0003974)1.79143870
145Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79098926
146Abnormality of the distal phalanges of the toes (HP:0010182)1.78566817
147Camptodactyly of toe (HP:0001836)1.78530206
148Decreased skull ossification (HP:0004331)1.78365399
149Anal stenosis (HP:0002025)1.78131361
150Spinal cord compression (HP:0002176)1.77410948
151Scapular winging (HP:0003691)1.76649778
152Arteriovenous malformation (HP:0100026)1.76201059
153Selective tooth agenesis (HP:0001592)1.75723441
154Anal atresia (HP:0002023)1.75321079
155Increased number of teeth (HP:0011069)1.74921767
156Abnormality of the calcaneus (HP:0008364)1.74914436
157Chorioretinal atrophy (HP:0000533)1.74714413
158Cortical dysplasia (HP:0002539)1.74714149
159Abnormality of the ischium (HP:0003174)1.74599643
160Abnormality of the parietal bone (HP:0002696)1.74135665
161Tracheomalacia (HP:0002779)1.73695076
162Gonadotropin excess (HP:0000837)1.73653795
163Coxa vara (HP:0002812)1.73475212
164Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.73302065
165Radial bowing (HP:0002986)1.72884158
166Delayed gross motor development (HP:0002194)1.72770126
167Long nose (HP:0003189)1.72496241
168Slender build (HP:0001533)1.72134011
169Pulmonic stenosis (HP:0001642)1.71571145
170Absent frontal sinuses (HP:0002688)1.71447662
171Arterial tortuosity (HP:0005116)1.71294283
172Cupped ribs (HP:0000887)1.70695999
173Knee flexion contracture (HP:0006380)1.69902095
174Dislocated radial head (HP:0003083)1.68224323
175Pterygium (HP:0001059)1.67315672
176Abnormality of the phalanges of the 2nd finger (HP:0009541)1.66853241
177Abnormality of the phalanges of the hallux (HP:0010057)1.66206194
178Shawl scrotum (HP:0000049)1.65856361
179Breech presentation (HP:0001623)1.65804326
180Buphthalmos (HP:0000557)1.65656741
181Aplasia involving forearm bones (HP:0009822)1.65641264

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.49844618
2LATS14.43743649
3PLK44.42564247
4EPHA33.63547811
5LATS23.29894657
6ACVR1B3.22381755
7TTN3.17538508
8WEE13.07565434
9EIF2AK33.07285147
10WNK32.77415678
11TRIM282.67504496
12PDGFRA2.62751787
13EPHB22.54054306
14NEK12.36601076
15TSSK62.33358674
16FRK2.17259835
17MKNK12.14479565
18EPHA22.10450736
19MST42.10392751
20STK38L2.02439190
21STK32.01786936
22ERBB31.89310527
23PNCK1.88796857
24RPS6KA41.84689586
25TNIK1.82272532
26PAK21.79749972
27FER1.73487843
28FGFR11.69135792
29PBK1.64003158
30SIK11.63495386
31MAP3K31.57488741
32PTK21.56037619
33TRPM71.55464256
34TGFBR11.54988875
35TESK11.51601013
36PIK3CA1.43191469
37PAK41.42924223
38TAOK21.41807382
39PKN21.40971168
40RIPK11.39855319
41ZAK1.39440263
42NUAK11.39237783
43DMPK1.37285780
44LIMK11.35713418
45PAK31.29741251
46BMX1.26246627
47TRIB31.26102530
48MAP3K41.25573484
49EPHA41.25235169
50PLK31.21975718
51MKNK21.18918505
52NEK91.17816802
53BRSK11.17074463
54BRAF1.16940305
55OBSCN1.13524686
56CDK81.12732736
57TGFBR21.10830542
58TAF10.98775834
59CDC70.98632512
60PLK20.95194084
61MET0.94301533
62PDGFRB0.93666331
63CDK120.91295069
64MTOR0.89491674
65ROCK10.89031650
66PTK60.85775347
67MAP4K20.85319239
68PTK2B0.80849744
69MAP3K80.79574226
70CDK70.79283591
71CDK60.78969701
72PRKD30.76444883
73BMPR1B0.73810925
74STK100.70247771
75MOS0.69932173
76MAP3K100.68207960
77AURKB0.65715436
78INSR0.65253207
79LRRK20.64620252
80STK390.64436912
81VRK10.62659155
82PIK3CG0.62022273
83TTK0.60182781
84PRKG20.59376334
85MUSK0.58633181
86SRPK10.57961815
87EIF2AK10.57106948
88BRSK20.54577899
89ILK0.54411734
90MAP2K30.54073418
91MYLK0.53925733
92SIK30.53628085
93ERBB20.51449102
94STK160.50707752
95EIF2AK20.50389325
96BCR0.49684082
97NEK20.49185911
98PLK10.48788431
99BRD40.48348334
100CASK0.48331931
101ERBB40.46829786
102BUB10.46713005
103PASK0.46229661
104TESK20.46218991
105FLT30.46032367
106ROCK20.44745839
107FGFR20.44486116
108CDK90.41908947
109CHEK20.41844820
110ATR0.41832220
111ADRBK10.41685621
112PAK60.40568650
113MAPK10.39371247
114DYRK30.39214636
115MELK0.39033798
116CAMK1D0.38437257
117ATM0.38329318
118PAK10.38182550
119CHEK10.38132280
120CDC42BPA0.36014444
121MAP3K120.35390598
122ALK0.34134326
123TIE10.33678564
124SRC0.32822411
125SCYL20.32470969
126PRKCE0.32024015
127KSR10.31700516
128IGF1R0.31170745
129NLK0.30639270
130MAP3K60.30567773
131OXSR10.28410588
132MINK10.28365579
133AKT30.27399904
134CLK10.27186294
135MAP2K10.26586039
136ERN10.26381472
137CCNB10.25869920
138CSNK1G10.24607233
139WNK40.23503155
140MAPK130.22999192
141GRK10.22304463
142PDK20.22004790

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.86310121
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.17342032
3Protein export_Homo sapiens_hsa030603.11244638
4Steroid biosynthesis_Homo sapiens_hsa001003.06812914
5Focal adhesion_Homo sapiens_hsa045102.69359624
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.64918142
7TGF-beta signaling pathway_Homo sapiens_hsa043502.59518704
8Proteasome_Homo sapiens_hsa030502.57398682
9Basal cell carcinoma_Homo sapiens_hsa052172.55872255
10Hippo signaling pathway_Homo sapiens_hsa043902.51514452
11Adherens junction_Homo sapiens_hsa045202.47128162
12Proteoglycans in cancer_Homo sapiens_hsa052052.35068895
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29568814
14MicroRNAs in cancer_Homo sapiens_hsa052062.27056657
15Basal transcription factors_Homo sapiens_hsa030222.12918806
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.11200760
17Bladder cancer_Homo sapiens_hsa052192.08806740
18Propanoate metabolism_Homo sapiens_hsa006402.06113005
19Small cell lung cancer_Homo sapiens_hsa052222.05099601
20Hedgehog signaling pathway_Homo sapiens_hsa043402.02980257
21Protein digestion and absorption_Homo sapiens_hsa049741.95465955
22Sulfur metabolism_Homo sapiens_hsa009201.92312554
23Fanconi anemia pathway_Homo sapiens_hsa034601.90675621
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.86672366
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.85551106
26Cell cycle_Homo sapiens_hsa041101.81347260
27p53 signaling pathway_Homo sapiens_hsa041151.79565815
28Malaria_Homo sapiens_hsa051441.78665130
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.77678849
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.65124397
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.63926324
32Dilated cardiomyopathy_Homo sapiens_hsa054141.63784910
33Melanoma_Homo sapiens_hsa052181.62611071
34Mismatch repair_Homo sapiens_hsa034301.60417377
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.58185997
36PI3K-Akt signaling pathway_Homo sapiens_hsa041511.56412856
37Wnt signaling pathway_Homo sapiens_hsa043101.55431083
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49333562
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43604941
40HTLV-I infection_Homo sapiens_hsa051661.40561836
41Amoebiasis_Homo sapiens_hsa051461.36313229
42Prostate cancer_Homo sapiens_hsa052151.35551890
43Axon guidance_Homo sapiens_hsa043601.35317768
44One carbon pool by folate_Homo sapiens_hsa006701.35245026
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.32435804
46RNA transport_Homo sapiens_hsa030131.31324842
47Pathways in cancer_Homo sapiens_hsa052001.30027300
48Regulation of actin cytoskeleton_Homo sapiens_hsa048101.29078359
49Pyruvate metabolism_Homo sapiens_hsa006201.28144650
50Chronic myeloid leukemia_Homo sapiens_hsa052201.27840937
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.24572857
52Shigellosis_Homo sapiens_hsa051311.15623871
53TNF signaling pathway_Homo sapiens_hsa046681.15467449
54Viral myocarditis_Homo sapiens_hsa054161.12583174
55Tight junction_Homo sapiens_hsa045301.08142633
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08060980
57Rap1 signaling pathway_Homo sapiens_hsa040151.03978175
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02828785
59Viral carcinogenesis_Homo sapiens_hsa052031.02623665
60Leukocyte transendothelial migration_Homo sapiens_hsa046701.01671469
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01166473
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99933593
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99571380
64Vitamin B6 metabolism_Homo sapiens_hsa007500.98684720
65Colorectal cancer_Homo sapiens_hsa052100.91560630
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91285984
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.89899450
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88788681
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86301446
70Pancreatic cancer_Homo sapiens_hsa052120.86125566
71Base excision repair_Homo sapiens_hsa034100.84118377
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83804905
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83492481
74Melanogenesis_Homo sapiens_hsa049160.81129500
75Hepatitis B_Homo sapiens_hsa051610.80826540
76Systemic lupus erythematosus_Homo sapiens_hsa053220.80246894
77HIF-1 signaling pathway_Homo sapiens_hsa040660.79648139
78Glioma_Homo sapiens_hsa052140.78713694
79Glutathione metabolism_Homo sapiens_hsa004800.78577153
80Thyroid cancer_Homo sapiens_hsa052160.77400197
81mRNA surveillance pathway_Homo sapiens_hsa030150.76844822
82Spliceosome_Homo sapiens_hsa030400.75689250
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73374520
84Renal cell carcinoma_Homo sapiens_hsa052110.71332693
85RNA polymerase_Homo sapiens_hsa030200.71006755
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70216317
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.69051099
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68613624
89Toxoplasmosis_Homo sapiens_hsa051450.68585143
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67957706
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67790280
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67516522
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67380953
94Fatty acid metabolism_Homo sapiens_hsa012120.66171190
95Platelet activation_Homo sapiens_hsa046110.65445097
96Notch signaling pathway_Homo sapiens_hsa043300.64562332
97FoxO signaling pathway_Homo sapiens_hsa040680.64281981
98Endometrial cancer_Homo sapiens_hsa052130.61659601
99Gap junction_Homo sapiens_hsa045400.60650624
100Nucleotide excision repair_Homo sapiens_hsa034200.59740592
101Purine metabolism_Homo sapiens_hsa002300.59271567
102Salmonella infection_Homo sapiens_hsa051320.58040314
103RNA degradation_Homo sapiens_hsa030180.57712024
104Apoptosis_Homo sapiens_hsa042100.54292284
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52187231
106Phagosome_Homo sapiens_hsa041450.51512640
107Fatty acid elongation_Homo sapiens_hsa000620.51375565
108Nitrogen metabolism_Homo sapiens_hsa009100.50753925
109MAPK signaling pathway_Homo sapiens_hsa040100.49728515
110Selenocompound metabolism_Homo sapiens_hsa004500.48557654
111Ras signaling pathway_Homo sapiens_hsa040140.48012680
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47634587
113Non-homologous end-joining_Homo sapiens_hsa034500.47406159
114Non-small cell lung cancer_Homo sapiens_hsa052230.46885920
115Renin-angiotensin system_Homo sapiens_hsa046140.46542974
116Fatty acid degradation_Homo sapiens_hsa000710.45286196
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44958986
118Epstein-Barr virus infection_Homo sapiens_hsa051690.43624228
119ErbB signaling pathway_Homo sapiens_hsa040120.42894192
120Lysine degradation_Homo sapiens_hsa003100.41939503
121Pyrimidine metabolism_Homo sapiens_hsa002400.41098463
122Butanoate metabolism_Homo sapiens_hsa006500.39880396
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.39678417
124Retinol metabolism_Homo sapiens_hsa008300.38949249
125Legionellosis_Homo sapiens_hsa051340.38045676
126Leishmaniasis_Homo sapiens_hsa051400.37504169
127mTOR signaling pathway_Homo sapiens_hsa041500.37218503
128Ovarian steroidogenesis_Homo sapiens_hsa049130.37054632
129Primary bile acid biosynthesis_Homo sapiens_hsa001200.36530592
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.36169621
131Hematopoietic cell lineage_Homo sapiens_hsa046400.36154399
132Alcoholism_Homo sapiens_hsa050340.35906572
133Fatty acid biosynthesis_Homo sapiens_hsa000610.35308301
134N-Glycan biosynthesis_Homo sapiens_hsa005100.33346885
135Estrogen signaling pathway_Homo sapiens_hsa049150.32817491
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32278807
137Biosynthesis of amino acids_Homo sapiens_hsa012300.32212511
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30353926
139Oocyte meiosis_Homo sapiens_hsa041140.30224772
140DNA replication_Homo sapiens_hsa030300.28643592
141Circadian rhythm_Homo sapiens_hsa047100.28440224
142cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27344142
143Homologous recombination_Homo sapiens_hsa034400.27195722
144NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27103656
145Metabolic pathways_Homo sapiens_hsa011000.24554332
146Mineral absorption_Homo sapiens_hsa049780.24058302
147Folate biosynthesis_Homo sapiens_hsa007900.23023608
148SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21193907

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