HAS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bundle of His cell to Purkinje myocyte communication (GO:0086069)7.39041952
2keratinocyte proliferation (GO:0043616)6.92382450
3surfactant homeostasis (GO:0043129)6.05018299
4establishment of skin barrier (GO:0061436)6.02434074
5negative regulation of keratinocyte proliferation (GO:0010839)5.94462838
6regulation of water loss via skin (GO:0033561)5.79596410
7chemical homeostasis within a tissue (GO:0048875)5.28089244
8gap junction assembly (GO:0016264)4.71742404
9keratinization (GO:0031424)4.70531325
10dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.69590432
11establishment of tissue polarity (GO:0007164)4.68143115
12establishment of planar polarity (GO:0001736)4.68143115
13layer formation in cerebral cortex (GO:0021819)4.64908059
14pyrimidine nucleobase catabolic process (GO:0006208)4.63160061
15regulation of keratinocyte proliferation (GO:0010837)4.57296428
16lateral sprouting from an epithelium (GO:0060601)4.47539685
17planar cell polarity pathway involved in neural tube closure (GO:0090179)4.44244058
18regulation of hair follicle development (GO:0051797)4.30540917
19keratinocyte differentiation (GO:0030216)4.23663700
20regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.17943169
21paraxial mesoderm development (GO:0048339)4.16463692
22pre-miRNA processing (GO:0031054)4.08589598
23cell migration in hindbrain (GO:0021535)4.06373980
24hemidesmosome assembly (GO:0031581)4.06122095
25regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.05602585
26negative regulation of cell fate specification (GO:0009996)4.04206379
27cell adhesion mediated by integrin (GO:0033627)4.04093736
28epidermis development (GO:0008544)3.96842436
29mesodermal cell differentiation (GO:0048333)3.91982426
30nucleobase catabolic process (GO:0046113)3.89079302
31multicellular organismal water homeostasis (GO:0050891)3.80479991
32intermediate filament organization (GO:0045109)3.80010082
33cellular response to vitamin D (GO:0071305)3.75879270
34central nervous system projection neuron axonogenesis (GO:0021952)3.65513576
35regulation of cell fate specification (GO:0042659)3.62881678
36mitotic sister chromatid cohesion (GO:0007064)3.62792406
37neuron projection extension involved in neuron projection guidance (GO:1902284)3.54864406
38axon extension involved in axon guidance (GO:0048846)3.54864406
39negative regulation of histone methylation (GO:0031061)3.54642037
40skin morphogenesis (GO:0043589)3.53487995
41negative regulation of chondrocyte differentiation (GO:0032331)3.53229101
42mitochondrion transport along microtubule (GO:0047497)3.48511822
43establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.48511822
44dendrite morphogenesis (GO:0048813)3.48399876
45regulation of posttranscriptional gene silencing (GO:0060147)3.45430749
46regulation of gene silencing by miRNA (GO:0060964)3.45430749
47regulation of gene silencing by RNA (GO:0060966)3.45430749
48epidermal cell differentiation (GO:0009913)3.28156742
49protein localization to endosome (GO:0036010)3.27454809
50axon extension (GO:0048675)3.26702844
51epithelial cell differentiation involved in prostate gland development (GO:0060742)3.22973129
52protein complex localization (GO:0031503)3.22470825
53Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.17115503
54ectoderm development (GO:0007398)3.14396584
55water homeostasis (GO:0030104)3.13306849
56adherens junction assembly (GO:0034333)3.13155958
57dendritic spine morphogenesis (GO:0060997)3.13091877
58positive regulation of epidermis development (GO:0045684)3.12499383
59nuclear pore complex assembly (GO:0051292)3.12404845
60negative regulation of epidermis development (GO:0045683)3.11941799
61cellular protein complex localization (GO:0034629)3.07401125
62negative regulation of cell fate commitment (GO:0010454)3.06933271
63cell-substrate adherens junction assembly (GO:0007045)3.06676132
64focal adhesion assembly (GO:0048041)3.06676132
65regulation of establishment of planar polarity (GO:0090175)3.06633595
66regulation of histone H3-K9 methylation (GO:0051570)3.04329987
67heterochromatin organization (GO:0070828)3.01600853
68notochord development (GO:0030903)3.01203049
69cytoplasmic mRNA processing body assembly (GO:0033962)2.99969106
70positive regulation of hair cycle (GO:0042635)2.99200254
71positive regulation of hair follicle development (GO:0051798)2.99200254
72cell junction assembly (GO:0034329)2.95979986
73endodermal cell differentiation (GO:0035987)2.95346839
74regulation of RNA export from nucleus (GO:0046831)2.94607632
75establishment of mitochondrion localization (GO:0051654)2.93728478
76hippo signaling (GO:0035329)2.93122189
77regulation of hair cycle (GO:0042634)2.93100895
78protein localization to microtubule (GO:0035372)2.92648323
79keratinocyte development (GO:0003334)2.91085530
80skin development (GO:0043588)2.90492443
81epithelial cell-cell adhesion (GO:0090136)2.90477982
82ganglion development (GO:0061548)2.88691866
83establishment of apical/basal cell polarity (GO:0035089)2.87776995
84positive regulation of epidermal cell differentiation (GO:0045606)2.87519039
85regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.86958791
86cell junction organization (GO:0034330)2.86718104
87neuron projection extension (GO:1990138)2.85589621
88ephrin receptor signaling pathway (GO:0048013)2.85534421
89central nervous system neuron axonogenesis (GO:0021955)2.85280929
90regulation of epidermis development (GO:0045682)2.83348880
91cell migration involved in sprouting angiogenesis (GO:0002042)2.83002852
92negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.82128745
93negative regulation of translation, ncRNA-mediated (GO:0040033)2.82128745
94regulation of translation, ncRNA-mediated (GO:0045974)2.82128745
95regulation of transcription from RNA polymerase I promoter (GO:0006356)2.80235255
96regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.76807397
97morphogenesis of embryonic epithelium (GO:0016331)2.76661370
98non-canonical Wnt signaling pathway (GO:0035567)2.74567792
99atrioventricular valve morphogenesis (GO:0003181)2.74443721
100renal system development (GO:0072001)2.73667349
101positive regulation of synapse maturation (GO:0090129)2.73613565
102convergent extension (GO:0060026)2.72090542
103cellular response to vitamin (GO:0071295)2.71124754
104exploration behavior (GO:0035640)2.70079223
105hair cycle (GO:0042633)2.70062314
106molting cycle (GO:0042303)2.70062314
107renal filtration (GO:0097205)2.69544977
108hypotonic response (GO:0006971)2.68797668
109establishment of nucleus localization (GO:0040023)2.68463151
110clathrin coat assembly (GO:0048268)2.68257402
111mammary gland development (GO:0030879)2.68068282
112regulation of clathrin-mediated endocytosis (GO:2000369)2.67990410
113establishment of integrated proviral latency (GO:0075713)2.67386364
114regulation of neuron migration (GO:2001222)2.66928625
115locomotory exploration behavior (GO:0035641)2.66098671
116regulation of cardioblast differentiation (GO:0051890)2.65658843
117nuclear pore organization (GO:0006999)2.65187057
118regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.64804930
119positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.64743713
120morphogenesis of an epithelial fold (GO:0060571)2.64040896
121proline transport (GO:0015824)2.63947558
122facial nerve structural organization (GO:0021612)2.62757826
123intestinal epithelial cell development (GO:0060576)2.62337893
124intermediate filament cytoskeleton organization (GO:0045104)2.62275234
125endothelial cell chemotaxis (GO:0035767)2.61460931
126regulation of short-term neuronal synaptic plasticity (GO:0048172)2.60762874
127peptidyl-lysine trimethylation (GO:0018023)2.59212478
128G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.58858181
129substrate-dependent cell migration (GO:0006929)2.58802176
130positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.58316518
131protein localization to kinetochore (GO:0034501)2.57310467
132semaphorin-plexin signaling pathway (GO:0071526)2.57097876
133gastrulation with mouth forming second (GO:0001702)2.55552658
134polarized epithelial cell differentiation (GO:0030859)2.55345699
135protein localization to synapse (GO:0035418)2.54230096
136axonal fasciculation (GO:0007413)2.53181318
137regulation of NFAT protein import into nucleus (GO:0051532)2.51111748
138neuron recognition (GO:0008038)2.50748346
139NLS-bearing protein import into nucleus (GO:0006607)2.50510386
140positive regulation of filopodium assembly (GO:0051491)2.49073954
141positive regulation of microtubule polymerization (GO:0031116)2.47578451
142regulation of nucleobase-containing compound transport (GO:0032239)2.46640041
143glial cell proliferation (GO:0014009)2.43413989
144regulation of axon extension involved in axon guidance (GO:0048841)2.43403301
145regulation of glutamate receptor signaling pathway (GO:1900449)2.42760809
146histone H3-K4 trimethylation (GO:0080182)2.41690868
147vocalization behavior (GO:0071625)2.41437168
148cell-substrate junction assembly (GO:0007044)2.39967882
149neuron cell-cell adhesion (GO:0007158)2.39806685
150histone lysine methylation (GO:0034968)2.38495166
151negative regulation of catenin import into nucleus (GO:0035414)2.38336937
152developmental cell growth (GO:0048588)2.38131924
153histone H3-K4 methylation (GO:0051568)2.37116288
154regulation of hippo signaling (GO:0035330)2.36559561
155plasma membrane repair (GO:0001778)2.36461313
156regulation of sister chromatid cohesion (GO:0007063)2.36395459
157negative regulation of Ras GTPase activity (GO:0034261)2.35623046
158spindle assembly involved in mitosis (GO:0090307)2.34441897
159head development (GO:0060322)2.33912470
160innervation (GO:0060384)2.33248713
161establishment of monopolar cell polarity (GO:0061162)2.33155691
162establishment or maintenance of monopolar cell polarity (GO:0061339)2.33155691
163positive regulation of axon extension (GO:0045773)2.32619905
164cytoskeletal anchoring at plasma membrane (GO:0007016)2.31972181
165stress granule assembly (GO:0034063)2.31726265
166peptidyl-threonine phosphorylation (GO:0018107)2.31599443
167synaptic vesicle maturation (GO:0016188)2.31106133
168epithelial cell fate commitment (GO:0072148)2.30873406
169homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.29178140
170regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.26782655
171organelle transport along microtubule (GO:0072384)2.26599249
172desmosome organization (GO:0002934)2.25531547
173regulation of dendritic spine morphogenesis (GO:0061001)2.22829772
174histone H2A monoubiquitination (GO:0035518)2.21884308
175regulation of transforming growth factor beta2 production (GO:0032909)2.20893021
176histone methylation (GO:0016571)2.20506208
177peptidyl-arginine methylation (GO:0018216)2.20418552
178peptidyl-arginine N-methylation (GO:0035246)2.20418552
179positive regulation of dendritic spine morphogenesis (GO:0061003)2.20063376
180regulation of Rac GTPase activity (GO:0032314)2.20021839
181cell-cell junction maintenance (GO:0045217)2.19639674
182cochlea development (GO:0090102)2.19075880
183regulation of cAMP-dependent protein kinase activity (GO:2000479)2.18202572
184nucleus localization (GO:0051647)2.18097032
185cell communication involved in cardiac conduction (GO:0086065)2.18053535
186regulation of catenin import into nucleus (GO:0035412)2.17795192
187peptidyl-threonine modification (GO:0018210)2.15271418
188peptidyl-lysine methylation (GO:0018022)2.15155006
189negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.14996401

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.63121193
2EZH2_22144423_ChIP-Seq_EOC_Human3.97975286
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.93194455
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.74938576
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.42332278
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.73931080
7SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.54680884
8SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.54680884
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.47793615
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42006986
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.39863345
12* TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.31230862
13HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.30330235
14* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.27351920
15* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.26465511
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.25774939
17AR_21909140_ChIP-Seq_LNCAP_Human2.13270021
18P63_26484246_Chip-Seq_KERATINOCYTES_Human2.09830627
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.09117689
20SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.00615901
21AR_21572438_ChIP-Seq_LNCaP_Human1.99982430
22KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.95495175
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.95495175
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.95495175
25* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.93017690
26TCF4_18268006_ChIP-ChIP_LS174T_Human1.92213593
27* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.90181471
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.82079346
29CLOCK_20551151_ChIP-Seq_293T_Human1.81509362
30SOX9_24532713_ChIP-Seq_HFSC_Mouse1.80037757
31NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.78246089
32* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.76604402
33KDM2B_26808549_Chip-Seq_K562_Human1.76496546
34* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75962978
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.69994944
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.68583676
37GBX2_23144817_ChIP-Seq_PC3_Human1.66581799
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.61762056
39FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.60203280
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59691442
41ATF3_27146783_Chip-Seq_COLON_Human1.58828429
42UBF1/2_26484160_Chip-Seq_HMECs_Human1.58290853
43TP53_16413492_ChIP-PET_HCT116_Human1.58282935
44DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.56452372
45* RARB_27405468_Chip-Seq_BRAIN_Mouse1.55554416
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55343236
47SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.53213480
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.52670006
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.52440167
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51915042
51AHR_22903824_ChIP-Seq_MCF-7_Human1.51792084
52* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.51479312
53ISL1_27105846_Chip-Seq_CPCs_Mouse1.50843969
54* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.50211223
55ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.48683917
56DROSHA_22980978_ChIP-Seq_HELA_Human1.47934723
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45940163
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45269779
59* KDM2B_26808549_Chip-Seq_JURKAT_Human1.44243866
60ESR1_21235772_ChIP-Seq_MCF-7_Human1.43481171
61* KDM2B_26808549_Chip-Seq_DND41_Human1.43152809
62ZNF274_21170338_ChIP-Seq_K562_Hela1.42091482
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41229674
64UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40659363
65ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.40562311
66ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39760579
67ZNF263_19887448_ChIP-Seq_K562_Human1.37827721
68* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37389975
69* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.36689871
70REST_21632747_ChIP-Seq_MESCs_Mouse1.35798773
71FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.35338381
72ESR1_20079471_ChIP-ChIP_T-47D_Human1.35051684
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.34284574
74MYC_19079543_ChIP-ChIP_MESCs_Mouse1.34066826
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33275847
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33275847
77* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31929616
78TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31279743
79* STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29939907
80YAP1_20516196_ChIP-Seq_MESCs_Mouse1.27351562
81SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27301113
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.27105016
83* ELK3_25401928_ChIP-Seq_HUVEC_Human1.22681455
84EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22344729
85HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21152072
86ESR2_21235772_ChIP-Seq_MCF-7_Human1.20721559
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20414944
88TCF7_22412390_ChIP-Seq_EML_Mouse1.20372390
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.20136307
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19617659
91FOXO3_23340844_ChIP-Seq_DLD1_Human1.19467107
92TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18813821
93RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18294384
94EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18294384
95* RACK7_27058665_Chip-Seq_MCF-7_Human1.17984921
96FUS_26573619_Chip-Seq_HEK293_Human1.16910817
97* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16828274
98AR_19668381_ChIP-Seq_PC3_Human1.16642023
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15650282
100CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15495907
101WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15489760
102KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15353598
103EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.14282897
104KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13987739
105* TP63_23658742_ChIP-Seq_EP156T_Human1.13396528
106SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13327982
107CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12811494
108RING1B_27294783_Chip-Seq_ESCs_Mouse1.12604827
109RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11807916
110P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11397769
111E2F7_22180533_ChIP-Seq_HELA_Human1.09971230
112* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.09833449
113NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09715022
114* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09535641
115CHD1_26751641_Chip-Seq_LNCaP_Human1.09504129
116ELK4_26923725_Chip-Seq_MESODERM_Mouse1.08556643
117* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08209007
118EZH2_27294783_Chip-Seq_ESCs_Mouse1.07338958
119RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06076663
120* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05697244
121* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05423861
122TP63_19390658_ChIP-ChIP_HaCaT_Human1.05280232
123SMAD_19615063_ChIP-ChIP_OVARY_Human1.05060163
124* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04131353
125GATA1_26923725_Chip-Seq_HPCs_Mouse1.03657854
126PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03329065
127SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03160530
128* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.01832413
129* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01639454
130JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01305812
131GATA6_25053715_ChIP-Seq_YYC3_Human1.01280929
132* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01183320
133* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01140613
134* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00923216
135ERG_21242973_ChIP-ChIP_JURKAT_Human0.99660829
136* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98942596
137CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98480268
138* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97764116
139NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97664720
140RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97456816
141SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97379014
142STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97345375
143STAT3_23295773_ChIP-Seq_U87_Human0.97293452
144* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97132513
145SMAD4_21799915_ChIP-Seq_A2780_Human0.96005388
146DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95941642
147NANOG_16153702_ChIP-ChIP_HESCs_Human0.95765877
148* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.95716723
149SMAD3_21741376_ChIP-Seq_HESCs_Human0.95588316
150* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95003144
151POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94907994
152MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94835029
153* SMAD3_21741376_ChIP-Seq_EPCs_Human0.94093986
154* SOX2_20726797_ChIP-Seq_SW620_Human0.91237114
155* KAP1_27257070_Chip-Seq_ESCs_Mouse0.90762959
156TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89873813
157EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.87630463
158* TP63_22573176_ChIP-Seq_HFKS_Human0.86288925
159* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.86001576
160HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84590277
161* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83178794
162ZFX_18555785_ChIP-Seq_MESCs_Mouse0.82934582
163KLF5_25053715_ChIP-Seq_YYC3_Human0.81826476
164* CJUN_26792858_Chip-Seq_BT549_Human0.81529564
165SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.80797652
166NANOG_21062744_ChIP-ChIP_HESCs_Human0.80180642
167MYCN_18555785_ChIP-Seq_MESCs_Mouse0.79647868
168HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.79623428
169ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.79243771
170EP300_21415370_ChIP-Seq_HL-1_Mouse0.78504280
171CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78392681
172TP53_18474530_ChIP-ChIP_U2OS_Human0.77464659
173MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.73457175
174CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72432758
175GATA3_24758297_ChIP-Seq_MCF-7_Human0.72045659

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.27394979
2MP0000579_abnormal_nail_morphology3.56249658
3MP0000566_synostosis3.50594258
4MP0003566_abnormal_cell_adhesion3.12194292
5MP0004859_abnormal_synaptic_plasticity2.91149863
6MP0002254_reproductive_system_inflammat2.72687636
7MP0002060_abnormal_skin_morphology2.61998593
8MP0005275_abnormal_skin_tensile2.59632185
9MP0003453_abnormal_keratinocyte_physiol2.56489166
10MP0003705_abnormal_hypodermis_morpholog2.48655960
11MP0004272_abnormal_basement_membrane2.36515949
12MP0004270_analgesia2.26962336
13MP0000383_abnormal_hair_follicle2.24766143
14MP0005076_abnormal_cell_differentiation2.20344712
15MP0000778_abnormal_nervous_system2.06685906
16MP0010678_abnormal_skin_adnexa1.99098834
17MP0010234_abnormal_vibrissa_follicle1.98368943
18MP0010030_abnormal_orbit_morphology1.88262157
19MP0010771_integument_phenotype1.86425696
20MP0004264_abnormal_extraembryonic_tissu1.84361021
21MP0004782_abnormal_surfactant_physiolog1.80741619
22MP0005248_abnormal_Harderian_gland1.78617385
23MP0005023_abnormal_wound_healing1.76167807
24MP0003890_abnormal_embryonic-extraembry1.75049220
25MP0003693_abnormal_embryo_hatching1.73346298
26MP0000537_abnormal_urethra_morphology1.64306896
27MP0000678_abnormal_parathyroid_gland1.62259983
28MP0002234_abnormal_pharynx_morphology1.58874265
29MP0004957_abnormal_blastocyst_morpholog1.58632448
30MP0000516_abnormal_urinary_system1.55503034
31MP0005367_renal/urinary_system_phenotyp1.55503034
32MP0003315_abnormal_perineum_morphology1.54041112
33MP0005187_abnormal_penis_morphology1.52782233
34MP0003755_abnormal_palate_morphology1.50943223
35MP0000647_abnormal_sebaceous_gland1.48804478
36MP0005409_darkened_coat_color1.48062474
37MP0002796_impaired_skin_barrier1.48020398
38MP0001849_ear_inflammation1.47134679
39MP0003635_abnormal_synaptic_transmissio1.46909383
40MP0008961_abnormal_basal_metabolism1.45459029
41MP0003119_abnormal_digestive_system1.45050766
42MP0003861_abnormal_nervous_system1.44844273
43MP0002184_abnormal_innervation1.42847929
44MP0003646_muscle_fatigue1.39248801
45MP0002063_abnormal_learning/memory/cond1.38709905
46MP0008932_abnormal_embryonic_tissue1.34471128
47MP0005257_abnormal_intraocular_pressure1.33608638
48MP0003935_abnormal_craniofacial_develop1.30705229
49MP0002084_abnormal_developmental_patter1.30552307
50MP0009672_abnormal_birth_weight1.28808463
51MP0003937_abnormal_limbs/digits/tail_de1.28563702
52MP0002734_abnormal_mechanical_nocicepti1.26654449
53MP0005423_abnormal_somatic_nervous1.26644890
54MP0001348_abnormal_lacrimal_gland1.25136386
55MP0000751_myopathy1.24029766
56MP0003941_abnormal_skin_development1.22728284
57MP0008789_abnormal_olfactory_epithelium1.21735261
58MP0010094_abnormal_chromosome_stability1.20954479
59MP0000427_abnormal_hair_cycle1.19899317
60MP0004233_abnormal_muscle_weight1.19706886
61MP0005623_abnormal_meninges_morphology1.18997634
62MP0003111_abnormal_nucleus_morphology1.17619463
63MP0008260_abnormal_autophagy1.17327679
64MP0000733_abnormal_muscle_development1.16471212
65MP0000467_abnormal_esophagus_morphology1.16317284
66MP0004197_abnormal_fetal_growth/weight/1.15996449
67MP0000762_abnormal_tongue_morphology1.14946573
68MP0005394_taste/olfaction_phenotype1.14863824
69MP0005499_abnormal_olfactory_system1.14863824
70MP0010352_gastrointestinal_tract_polyps1.14830364
71MP0009780_abnormal_chondrocyte_physiolo1.14604035
72MP0009931_abnormal_skin_appearance1.14312315
73MP0004858_abnormal_nervous_system1.13930821
74MP0002085_abnormal_embryonic_tissue1.12795202
75MP0000627_abnormal_mammary_gland1.12293471
76MP0009703_decreased_birth_body1.11551219
77MP0001299_abnormal_eye_distance/1.10539093
78MP0001346_abnormal_lacrimal_gland1.10172376
79MP0009053_abnormal_anal_canal1.09610695
80MP0002089_abnormal_postnatal_growth/wei1.09510306
81MP0004811_abnormal_neuron_physiology1.09493933
82MP0003123_paternal_imprinting1.09040896
83MP0003718_maternal_effect1.07326679
84MP0003121_genomic_imprinting1.06376957
85MP0000462_abnormal_digestive_system1.05519640
86MP0004381_abnormal_hair_follicle1.05426628
87MP0002152_abnormal_brain_morphology1.04806978
88MP0002098_abnormal_vibrissa_morphology1.04716294
89MP0003787_abnormal_imprinting1.01540774
90MP0001188_hyperpigmentation1.00148986
91MP0008770_decreased_survivor_rate0.99662173
92MP0000955_abnormal_spinal_cord0.99122437
93MP0003385_abnormal_body_wall0.98078378
94MP0005380_embryogenesis_phenotype0.96603373
95MP0001672_abnormal_embryogenesis/_devel0.96603373
96MP0000377_abnormal_hair_follicle0.95865802
97MP0003567_abnormal_fetal_cardiomyocyte0.95624701
98MP0002116_abnormal_craniofacial_bone0.95145205
99MP0003303_peritoneal_inflammation0.92611668
100MP0002081_perinatal_lethality0.91715620
101MP0001216_abnormal_epidermal_layer0.91394668
102MP0004185_abnormal_adipocyte_glucose0.90300104
103MP0003115_abnormal_respiratory_system0.90102266
104MP0003984_embryonic_growth_retardation0.89586827
105MP0002088_abnormal_embryonic_growth/wei0.89095887
106MP0001191_abnormal_skin_condition0.87829621
107MP0000428_abnormal_craniofacial_morphol0.87262153
108MP0002233_abnormal_nose_morphology0.86540232
109MP0000350_abnormal_cell_proliferation0.86272281
110MP0004885_abnormal_endolymph0.86151707
111MP0005501_abnormal_skin_physiology0.83535119
112MP0000432_abnormal_head_morphology0.83328818
113MP0001340_abnormal_eyelid_morphology0.82528984
114MP0002102_abnormal_ear_morphology0.81606185
115MP0001697_abnormal_embryo_size0.81471203
116MP0002086_abnormal_extraembryonic_tissu0.81114796
117MP0002111_abnormal_tail_morphology0.80993435
118MP0008877_abnormal_DNA_methylation0.80917061
119MP0002697_abnormal_eye_size0.80484628
120MP0004130_abnormal_muscle_cell0.80330427
121MP0004019_abnormal_vitamin_homeostasis0.80081211
122MP0002572_abnormal_emotion/affect_behav0.79576917
123MP0001293_anophthalmia0.79036794
124MP0001730_embryonic_growth_arrest0.78462812
125MP0004947_skin_inflammation0.74899497
126MP0005197_abnormal_uvea_morphology0.74853804
127MP0003091_abnormal_cell_migration0.70721855
128MP0001286_abnormal_eye_development0.69293769
129MP0000367_abnormal_coat/_hair0.67131424
130MP0000858_altered_metastatic_potential0.65774781
131MP0002080_prenatal_lethality0.64821992
132MP0006292_abnormal_olfactory_placode0.64496912
133MP0003950_abnormal_plasma_membrane0.63905678
134MP0002177_abnormal_outer_ear0.63390831
135MP0000534_abnormal_ureter_morphology0.62362911
136MP0002282_abnormal_trachea_morphology0.61219087
137MP0005621_abnormal_cell_physiology0.59520269
138MP0002925_abnormal_cardiovascular_devel0.57917489
139MP0002877_abnormal_melanocyte_morpholog0.57548439
140MP0003077_abnormal_cell_cycle0.55551218
141MP0005083_abnormal_biliary_tract0.53904063
142MP0010368_abnormal_lymphatic_system0.53293668

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)7.13124465
2Alopecia of scalp (HP:0002293)5.68406078
3Palmoplantar hyperkeratosis (HP:0000972)5.22772172
4Right ventricular cardiomyopathy (HP:0011663)4.82429433
5Selective tooth agenesis (HP:0001592)4.76357882
6Nail dystrophy (HP:0008404)4.59488173
7Ridged nail (HP:0001807)4.33761278
8Pterygium (HP:0001059)3.77507260
9Oral leukoplakia (HP:0002745)3.76820096
10Abnormality of the salivary glands (HP:0010286)3.69598653
11Abnormal hair laboratory examination (HP:0003328)3.65219616
12Absent eyelashes (HP:0000561)3.60577679
13Milia (HP:0001056)3.58694116
14Sparse eyelashes (HP:0000653)3.56330355
15Abnormal blistering of the skin (HP:0008066)3.51660915
16Short 4th metacarpal (HP:0010044)3.31723541
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.31723541
18Hypoplasia of dental enamel (HP:0006297)3.25802834
19Hyperacusis (HP:0010780)3.25275348
20Lip pit (HP:0100267)3.23923807
21Hypotrichosis (HP:0001006)3.20010079
22Fragile skin (HP:0001030)3.01072213
23Elfin facies (HP:0004428)2.99646118
24Natal tooth (HP:0000695)2.96037516
25Oligodontia (HP:0000677)2.91014462
26Renal duplication (HP:0000075)2.86049557
27Renovascular hypertension (HP:0100817)2.81710477
28Abnormality of placental membranes (HP:0011409)2.68099373
29Amniotic constriction ring (HP:0009775)2.68099373
30Popliteal pterygium (HP:0009756)2.67631850
31Overriding aorta (HP:0002623)2.66230319
32Aplasia cutis congenita (HP:0001057)2.65471723
33Insomnia (HP:0100785)2.64904261
34Heterotopia (HP:0002282)2.63925306
35Ankyloglossia (HP:0010296)2.63604414
36Breast hypoplasia (HP:0003187)2.61167108
37Abnormality of the axillary hair (HP:0100134)2.57920418
38Abnormality of secondary sexual hair (HP:0009888)2.57920418
39Neurofibrillary tangles (HP:0002185)2.54607123
40Facial hemangioma (HP:0000329)2.51391534
41Anonychia (HP:0001798)2.50726323
42Mutism (HP:0002300)2.49203431
43Esophageal atresia (HP:0002032)2.46766909
44Amyotrophic lateral sclerosis (HP:0007354)2.45518927
45Abnormality of the lacrimal duct (HP:0011481)2.45045881
46Increased nuchal translucency (HP:0010880)2.43332724
47Abnormality of the 4th metacarpal (HP:0010012)2.42973769
48Abnormality of the lower motor neuron (HP:0002366)2.42400013
49Blepharitis (HP:0000498)2.41541901
50Nasolacrimal duct obstruction (HP:0000579)2.40196372
51Corneal erosion (HP:0200020)2.38204464
52Abnormality of nail color (HP:0100643)2.35506803
53Abnormality of the astrocytes (HP:0100707)2.35419136
54Astrocytoma (HP:0009592)2.35419136
55Papillary thyroid carcinoma (HP:0002895)2.32995769
56Genetic anticipation (HP:0003743)2.28279199
57Palmoplantar keratoderma (HP:0000982)2.25296623
58Excessive salivation (HP:0003781)2.20897638
59Drooling (HP:0002307)2.20897638
60Absent hair (HP:0002298)2.19872007
61Fragile nails (HP:0001808)2.19285642
62Aqueductal stenosis (HP:0002410)2.18968318
63Inappropriate behavior (HP:0000719)2.17600232
64Macroorchidism (HP:0000053)2.17272493
65Dry hair (HP:0011359)2.15978108
66Thick nail (HP:0001805)2.15796578
67Sacral dimple (HP:0000960)2.15392029
68Pointed chin (HP:0000307)2.15262261
69Septate vagina (HP:0001153)2.14512151
70Abnormality of the labia minora (HP:0012880)2.14134408
71Carious teeth (HP:0000670)2.11996894
72Abnormality of the nasolacrimal system (HP:0000614)2.10453310
73Flat cornea (HP:0007720)2.09592660
74Medulloblastoma (HP:0002885)2.08774238
75Shallow orbits (HP:0000586)2.07882366
76Neoplasm of the oral cavity (HP:0100649)2.07394236
77Cortical dysplasia (HP:0002539)2.05033400
78Labial hypoplasia (HP:0000066)2.04907744
79Abnormality of oral frenula (HP:0000190)2.04754678
80Cerebral inclusion bodies (HP:0100314)2.04281527
81Atrophic scars (HP:0001075)2.02748278
82Obsessive-compulsive behavior (HP:0000722)2.02072949
83Hypoplastic female external genitalia (HP:0012815)2.02059049
84Urethral obstruction (HP:0000796)2.00828067
85Subacute progressive viral hepatitis (HP:0006572)1.99499766
86Hepatoblastoma (HP:0002884)1.98491415
87Coronal craniosynostosis (HP:0004440)1.98244345
88Obstructive sleep apnea (HP:0002870)1.97506268
89Trismus (HP:0000211)1.96798042
90Hypodontia (HP:0000668)1.95904888
91Ectropion (HP:0000656)1.95167588
92Megalocornea (HP:0000485)1.94637861
93Lower limb amyotrophy (HP:0007210)1.92331909
94Deviation of the thumb (HP:0009603)1.91318862
95Laryngomalacia (HP:0001601)1.90912351
96Split foot (HP:0001839)1.90493267
97Hyporeflexia of lower limbs (HP:0002600)1.89510457
98Follicular hyperkeratosis (HP:0007502)1.89343484
99Long eyelashes (HP:0000527)1.89283476
100Volvulus (HP:0002580)1.86653399
101Depressed nasal tip (HP:0000437)1.86279912
102Neoplasm of the adrenal cortex (HP:0100641)1.84550014
103Aplasia/Hypoplasia of the sternum (HP:0006714)1.84445443
104Insidious onset (HP:0003587)1.83977829
105Termporal pattern (HP:0011008)1.83977829
106Plantar hyperkeratosis (HP:0007556)1.83400570
107Abnormality of the diencephalon (HP:0010662)1.82098071
108Xerostomia (HP:0000217)1.81816896
109Broad-based gait (HP:0002136)1.80948790
110Curly hair (HP:0002212)1.79732570
111Abnormality of the neuromuscular junction (HP:0003398)1.79659563
112Fatigable weakness (HP:0003473)1.79659563
113Squamous cell carcinoma (HP:0002860)1.78795517
114Bowel diverticulosis (HP:0005222)1.78618764
115Abnormality of the dental root (HP:0006486)1.78039302
116Taurodontia (HP:0000679)1.78039302
117Abnormality of permanent molar morphology (HP:0011071)1.78039302
118Skull defect (HP:0001362)1.77549450
119Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.77533780
120Arterial tortuosity (HP:0005116)1.77194728
121Hypoplastic labia majora (HP:0000059)1.77065018
122Difficulty running (HP:0009046)1.76748510
123Congenital ichthyosiform erythroderma (HP:0007431)1.75729661
124Short phalanx of the thumb (HP:0009660)1.74771382
125Urinary urgency (HP:0000012)1.74418477
126Hypohidrosis (HP:0000966)1.74298578
127Woolly hair (HP:0002224)1.73557105
128Abnormality of the fingernails (HP:0001231)1.73553881
129Erythroderma (HP:0001019)1.72395686
130Vertebral arch anomaly (HP:0008438)1.71250461
131Ependymoma (HP:0002888)1.71107481
132Poikiloderma (HP:0001029)1.70780154
133Shoulder girdle muscle weakness (HP:0003547)1.70354424
134Bronchomalacia (HP:0002780)1.67648525
135Midline defect of the nose (HP:0004122)1.66333822
136Complete atrioventricular canal defect (HP:0001674)1.65746766
137Split hand (HP:0001171)1.65106585
138Apathy (HP:0000741)1.65035867
139Genu recurvatum (HP:0002816)1.64992097
140Glioma (HP:0009733)1.64887856
141Pili torti (HP:0003777)1.64378483
142Hyperhidrosis (HP:0000975)1.64148298
143Megalencephaly (HP:0001355)1.62737681
144Urinary bladder sphincter dysfunction (HP:0002839)1.62736890
145Multifactorial inheritance (HP:0001426)1.62444028
146Sandal gap (HP:0001852)1.62188378
147Sparse scalp hair (HP:0002209)1.61837440
148Hypoplastic ischia (HP:0003175)1.61529596
149Bladder carcinoma (HP:0002862)1.61179161
150Bladder neoplasm (HP:0009725)1.61179161
151Transitional cell carcinoma of the bladder (HP:0006740)1.61115935
152Abnormality of molar (HP:0011077)1.60793496
153Abnormality of molar morphology (HP:0011070)1.60793496
154Disinhibition (HP:0000734)1.60787253
155Abnormality of the labia (HP:0000058)1.60246811
156Palmar hyperkeratosis (HP:0010765)1.60076863
157Abnormality of the corticospinal tract (HP:0002492)1.59453112
158Erythema (HP:0010783)1.58063655
159Skin pits (HP:0100276)1.57718695
160Aplasia/Hypoplasia of the breasts (HP:0010311)1.56511919
161Advanced eruption of teeth (HP:0006288)1.56261923
162Ulnar bowing (HP:0003031)1.55979244
163Prominent nose (HP:0000448)1.55961556
164Proximal placement of thumb (HP:0009623)1.55904315
165Abnormality of the gastric mucosa (HP:0004295)1.55710947
166Increased connective tissue (HP:0009025)1.55517970
167Uterine leiomyosarcoma (HP:0002891)1.55266806
168Leiomyosarcoma (HP:0100243)1.55266806
169Abnormality of the pubic bones (HP:0003172)1.54329093
170Overgrowth (HP:0001548)1.53632639
171Neoplasm of the heart (HP:0100544)1.53360552
172Abnormality of the labia majora (HP:0012881)1.53003275
173Progressive cerebellar ataxia (HP:0002073)1.52534096
174Patellar dislocation (HP:0002999)1.52383369
175Abnormality of the dental pulp (HP:0006479)1.52327980
176Fibrous tissue neoplasm (HP:0012316)1.51523729
177Absent eyebrow (HP:0002223)1.51472327
178Dehydration (HP:0001944)1.48742082
179Abnormality of the distal phalanx of the thumb (HP:0009617)1.47400500
180Aplasia involving bones of the upper limbs (HP:0009823)1.46497233
181Aplasia of the phalanges of the hand (HP:0009802)1.46497233
182Aplasia involving bones of the extremities (HP:0009825)1.46497233

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.10949762
2MST1R5.87957718
3MET4.08265579
4CDK123.73022356
5MAP3K93.30530352
6LATS23.04993105
7NTRK12.95824755
8LMTK22.58762690
9PAK42.52262725
10EPHB12.37136260
11LATS12.37111400
12PHKG22.33472953
13PHKG12.33472953
14ARAF2.33067909
15SIK12.32248853
16PTK22.29913493
17NTRK22.23323294
18DYRK22.08821495
19TGFBR11.81912999
20CAMK1G1.79500640
21TAOK11.79194619
22STK241.68314084
23EPHA21.66565519
24TSSK61.61995519
25MAP3K41.58645049
26SMG11.54374505
27MAP3K61.53886333
28SIK21.53462566
29PNCK1.53173914
30RIPK11.51813675
31CAMK1D1.47906991
32BRD41.45938251
33MINK11.42312761
34MAPK131.37660029
35TTN1.33695478
36DMPK1.27927115
37NME21.23311439
38PKN21.19154443
39CSNK1A1L1.18403796
40PAK61.16793545
41ICK1.16421262
42MARK21.15111184
43EPHA41.13998368
44MTOR1.13191067
45PBK1.10957618
46STK38L1.10228020
47TYRO31.08802998
48MST41.08307081
49CSNK1G21.06506062
50FGFR21.06449189
51FLT31.06131553
52KSR11.04150379
53BUB11.01742155
54PTK61.01652345
55SRPK11.01342388
56NTRK31.00253263
57TAOK20.99742622
58STK110.97629071
59CHEK20.94804041
60PIM20.92779402
61ALK0.91693006
62TRIB30.91067597
63PDK40.90014903
64PDK30.90014903
65ERBB30.89485251
66MAP3K100.89270305
67BRSK20.87920580
68DYRK1A0.85986887
69PRKD30.84107928
70NEK20.82479921
71MKNK10.79731164
72STK30.78752237
73STK380.78455680
74CSNK1D0.77432687
75SCYL20.77043237
76BMX0.75900925
77EPHB20.75659580
78RET0.75477022
79CDC70.74871714
80MAP2K40.73813581
81MAP3K20.73805117
82PLK20.72769500
83KSR20.72486193
84BRAF0.71099120
85FGFR10.66490404
86PDGFRB0.66357414
87MAP3K70.66150783
88CDK50.66023474
89EIF2AK20.64321155
90MAPK120.63694545
91ERBB40.63486089
92PKN10.62949897
93CSNK1G30.62329264
94MAPK100.61629626
95CSNK1G10.60620449
96EEF2K0.59557345
97TTK0.58821409
98ATM0.58518857
99SGK10.58458130
100PRKCI0.58330468
101MKNK20.58096284
102MAP2K70.56393737
103NEK60.55594527
104AKT20.55503334
105ZAK0.54735902
106WNK10.52518323
107PRKAA10.51976509
108MAP3K130.51928079
109ERN10.51291861
110CDK90.50969265
111MAP3K30.50595016
112ROCK20.50554594
113PLK30.49965225
114MAPK90.49755158
115CDK20.49165054
116MAP3K80.49112422
117EIF2AK10.48931107
118MAPK80.48896682
119BRSK10.48780854
120CHEK10.47556839
121CDK10.47153057
122FGFR40.46885506
123TRIM280.46267423
124PRKDC0.45695386
125GSK3B0.45599544
126PLK10.44524528
127MAP2K60.44070150
128DAPK20.43593101
129PDGFRA0.43591391
130ATR0.42923603
131IRAK30.42317916
132DYRK30.42181282
133ERBB20.41820404
134CDC42BPA0.41214756
135RPS6KA20.39550098
136FER0.39510236
137FGFR30.39474029
138DDR20.38304621
139NME10.37290034
140PRKCZ0.37270486
141CDK60.36363590
142CSNK1E0.36215038
143CAMK40.36211296
144FRK0.35607443
145AURKB0.33905248
146RPS6KA40.33638377
147CDK70.33249529
148AURKA0.31947989
149RPS6KA10.31453757
150MELK0.31137238
151GSK3A0.30122621
152CDK80.29598314
153BCR0.29311174
154RAF10.29233111
155VRK20.24797462
156WEE10.24576535
157TAF10.23869671
158PAK20.23134516
159FGR0.22564519
160EIF2AK30.21583261

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001002.04726775
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.99428117
3Axon guidance_Homo sapiens_hsa043601.97791831
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.91641279
5Endometrial cancer_Homo sapiens_hsa052131.89546107
6Cell cycle_Homo sapiens_hsa041101.88104236
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.87633261
8Basal cell carcinoma_Homo sapiens_hsa052171.86179761
9Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.79693874
10p53 signaling pathway_Homo sapiens_hsa041151.74984959
11Long-term potentiation_Homo sapiens_hsa047201.70256192
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.69466058
13mTOR signaling pathway_Homo sapiens_hsa041501.66615922
14Dorso-ventral axis formation_Homo sapiens_hsa043201.58596634
15Nicotine addiction_Homo sapiens_hsa050331.58172059
16Amoebiasis_Homo sapiens_hsa051461.58050733
17Bladder cancer_Homo sapiens_hsa052191.56894895
18Colorectal cancer_Homo sapiens_hsa052101.54272490
19Glioma_Homo sapiens_hsa052141.46624191
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46500428
21Renal cell carcinoma_Homo sapiens_hsa052111.43552685
22MicroRNAs in cancer_Homo sapiens_hsa052061.43048336
23Lysine degradation_Homo sapiens_hsa003101.42658734
24Estrogen signaling pathway_Homo sapiens_hsa049151.41641087
25Hippo signaling pathway_Homo sapiens_hsa043901.41095012
26GnRH signaling pathway_Homo sapiens_hsa049121.41072149
27Type II diabetes mellitus_Homo sapiens_hsa049301.40565137
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.39603005
29ErbB signaling pathway_Homo sapiens_hsa040121.37821843
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.37743625
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.34713010
32Thyroid hormone signaling pathway_Homo sapiens_hsa049191.34344855
33RNA transport_Homo sapiens_hsa030131.33451662
34Hedgehog signaling pathway_Homo sapiens_hsa043401.32368147
35Circadian entrainment_Homo sapiens_hsa047131.31755718
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.31219308
37Oxytocin signaling pathway_Homo sapiens_hsa049211.27826923
38Melanogenesis_Homo sapiens_hsa049161.27036996
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.26253045
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26201379
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25765419
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.25104199
43Oocyte meiosis_Homo sapiens_hsa041141.24810783
44Adherens junction_Homo sapiens_hsa045201.22515262
45Gap junction_Homo sapiens_hsa045401.21314744
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.20857223
47Dopaminergic synapse_Homo sapiens_hsa047281.19113435
48VEGF signaling pathway_Homo sapiens_hsa043701.18748102
49Long-term depression_Homo sapiens_hsa047301.18533353
50Non-small cell lung cancer_Homo sapiens_hsa052231.18102295
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17458363
52Renin secretion_Homo sapiens_hsa049241.17077355
53Wnt signaling pathway_Homo sapiens_hsa043101.16753764
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16339384
55Glutamatergic synapse_Homo sapiens_hsa047241.15833776
56Spliceosome_Homo sapiens_hsa030401.15048046
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14525708
58Viral myocarditis_Homo sapiens_hsa054161.14053010
59Cholinergic synapse_Homo sapiens_hsa047251.13798505
60mRNA surveillance pathway_Homo sapiens_hsa030151.13131949
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13042367
62Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12270438
63Chronic myeloid leukemia_Homo sapiens_hsa052201.12091131
64Longevity regulating pathway - mammal_Homo sapiens_hsa042111.10271416
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09866298
66Insulin signaling pathway_Homo sapiens_hsa049101.09165178
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08355971
68Choline metabolism in cancer_Homo sapiens_hsa052311.06816770
69Amphetamine addiction_Homo sapiens_hsa050311.06429837
70Central carbon metabolism in cancer_Homo sapiens_hsa052301.06314778
71Alcoholism_Homo sapiens_hsa050341.06043407
72Notch signaling pathway_Homo sapiens_hsa043301.05749434
73Pancreatic cancer_Homo sapiens_hsa052121.04960300
74Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03489868
75Dilated cardiomyopathy_Homo sapiens_hsa054141.03394399
76MAPK signaling pathway_Homo sapiens_hsa040100.99333355
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.96695179
78Gastric acid secretion_Homo sapiens_hsa049710.96672317
79Focal adhesion_Homo sapiens_hsa045100.95471844
80Proteoglycans in cancer_Homo sapiens_hsa052050.95076191
81DNA replication_Homo sapiens_hsa030300.94285285
82PI3K-Akt signaling pathway_Homo sapiens_hsa041510.93862280
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93569401
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93045867
85Small cell lung cancer_Homo sapiens_hsa052220.92642020
86Sphingolipid metabolism_Homo sapiens_hsa006000.92526933
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.92342953
88cAMP signaling pathway_Homo sapiens_hsa040240.90967714
89Protein digestion and absorption_Homo sapiens_hsa049740.90862852
90AMPK signaling pathway_Homo sapiens_hsa041520.90683212
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90509794
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90453096
93Systemic lupus erythematosus_Homo sapiens_hsa053220.88044673
94Salivary secretion_Homo sapiens_hsa049700.87044485
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86528269
96TGF-beta signaling pathway_Homo sapiens_hsa043500.86166777
97Glucagon signaling pathway_Homo sapiens_hsa049220.85931653
98Mismatch repair_Homo sapiens_hsa034300.85233003
99Rap1 signaling pathway_Homo sapiens_hsa040150.85122671
100Insulin resistance_Homo sapiens_hsa049310.84741912
101Morphine addiction_Homo sapiens_hsa050320.82137239
102ECM-receptor interaction_Homo sapiens_hsa045120.80634598
103Pathways in cancer_Homo sapiens_hsa052000.79607004
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79035763
105Olfactory transduction_Homo sapiens_hsa047400.78870919
106Ras signaling pathway_Homo sapiens_hsa040140.78718320
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.78361238
108Tight junction_Homo sapiens_hsa045300.77807791
109Cocaine addiction_Homo sapiens_hsa050300.76975260
110Prolactin signaling pathway_Homo sapiens_hsa049170.76712264
111Prostate cancer_Homo sapiens_hsa052150.75347480
112Serotonergic synapse_Homo sapiens_hsa047260.74325849
113GABAergic synapse_Homo sapiens_hsa047270.73636391
114Acute myeloid leukemia_Homo sapiens_hsa052210.73302425
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.72054844
116Calcium signaling pathway_Homo sapiens_hsa040200.71913013
117HTLV-I infection_Homo sapiens_hsa051660.71804975
118Melanoma_Homo sapiens_hsa052180.71781008
119FoxO signaling pathway_Homo sapiens_hsa040680.71182126
120Thyroid cancer_Homo sapiens_hsa052160.70643008
121Basal transcription factors_Homo sapiens_hsa030220.70440449
122Circadian rhythm_Homo sapiens_hsa047100.69279756
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69069503
124Insulin secretion_Homo sapiens_hsa049110.67890082
125Biosynthesis of amino acids_Homo sapiens_hsa012300.67045823
126Inositol phosphate metabolism_Homo sapiens_hsa005620.65938871
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65763422
128RNA polymerase_Homo sapiens_hsa030200.64845818
129B cell receptor signaling pathway_Homo sapiens_hsa046620.64039734
130Shigellosis_Homo sapiens_hsa051310.60443489
131Selenocompound metabolism_Homo sapiens_hsa004500.60237017
132N-Glycan biosynthesis_Homo sapiens_hsa005100.59993885
133Prion diseases_Homo sapiens_hsa050200.54672873
134Galactose metabolism_Homo sapiens_hsa000520.52763072
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52504081
136Vitamin digestion and absorption_Homo sapiens_hsa049770.50357736
137Apoptosis_Homo sapiens_hsa042100.48056303
138Base excision repair_Homo sapiens_hsa034100.44709567
139AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44510604
140Nucleotide excision repair_Homo sapiens_hsa034200.42721992
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41587171
142Toxoplasmosis_Homo sapiens_hsa051450.39157747
143Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38527250
144Hepatitis C_Homo sapiens_hsa051600.38339840
145Non-homologous end-joining_Homo sapiens_hsa034500.38328788
146Phenylalanine metabolism_Homo sapiens_hsa003600.36788073
147Ovarian steroidogenesis_Homo sapiens_hsa049130.36215577
148Ether lipid metabolism_Homo sapiens_hsa005650.31615461
149Fructose and mannose metabolism_Homo sapiens_hsa000510.30036932

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