HAT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.36964157
2DNA replication initiation (GO:0006270)5.22843195
3DNA strand elongation (GO:0022616)5.09827944
4telomere maintenance via semi-conservative replication (GO:0032201)5.02898386
5DNA unwinding involved in DNA replication (GO:0006268)4.84924769
6DNA replication checkpoint (GO:0000076)4.76720958
7telomere maintenance via recombination (GO:0000722)4.55991048
8DNA double-strand break processing (GO:0000729)4.51679426
9chromatin remodeling at centromere (GO:0031055)4.42922280
10nucleobase biosynthetic process (GO:0046112)4.42236610
11CENP-A containing nucleosome assembly (GO:0034080)4.38249747
12mitotic recombination (GO:0006312)4.37502352
13mitotic metaphase plate congression (GO:0007080)4.32876721
14formation of translation preinitiation complex (GO:0001731)4.31746212
15purine nucleobase biosynthetic process (GO:0009113)4.30090541
16protein localization to kinetochore (GO:0034501)4.25418859
17nuclear pore organization (GO:0006999)4.17231740
18telomere maintenance via telomere lengthening (GO:0010833)4.10035517
19maturation of SSU-rRNA (GO:0030490)4.08186482
20IMP biosynthetic process (GO:0006188)4.03236655
21nucleotide-excision repair, DNA gap filling (GO:0006297)4.02160234
22kinetochore organization (GO:0051383)3.95864354
23mitotic nuclear envelope disassembly (GO:0007077)3.95046672
24DNA ligation (GO:0006266)3.91282481
25ribosomal small subunit assembly (GO:0000028)3.90971714
26nuclear pore complex assembly (GO:0051292)3.87095438
27cullin deneddylation (GO:0010388)3.84933678
28attachment of spindle microtubules to kinetochore (GO:0008608)3.81617436
29metaphase plate congression (GO:0051310)3.81379899
30regulation of centriole replication (GO:0046599)3.80713831
31negative regulation of DNA-dependent DNA replication (GO:2000104)3.80046982
32* DNA replication-independent nucleosome assembly (GO:0006336)3.77935133
33* DNA replication-independent nucleosome organization (GO:0034724)3.77935133
34replication fork processing (GO:0031297)3.77748193
35mitotic sister chromatid cohesion (GO:0007064)3.76904577
36regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.76086058
37ribosome assembly (GO:0042255)3.73226762
38somatic diversification of immune receptors via somatic mutation (GO:0002566)3.72500112
39somatic hypermutation of immunoglobulin genes (GO:0016446)3.72500112
40histone exchange (GO:0043486)3.70067117
41folic acid-containing compound biosynthetic process (GO:0009396)3.67315323
42regulation of DNA endoreduplication (GO:0032875)3.66829614
43ribosome biogenesis (GO:0042254)3.66664644
44DNA catabolic process, exonucleolytic (GO:0000738)3.65411977
45nuclear envelope disassembly (GO:0051081)3.65373019
46membrane disassembly (GO:0030397)3.65373019
47double-strand break repair via nonhomologous end joining (GO:0006303)3.65172563
48non-recombinational repair (GO:0000726)3.65172563
49protein localization to chromosome, centromeric region (GO:0071459)3.63302695
50regulation of helicase activity (GO:0051095)3.60096329
51protein deneddylation (GO:0000338)3.59016030
52kinetochore assembly (GO:0051382)3.56944488
53* DNA replication-dependent nucleosome assembly (GO:0006335)3.55754873
54* DNA replication-dependent nucleosome organization (GO:0034723)3.55754873
55IMP metabolic process (GO:0046040)3.55652598
56ribosomal large subunit biogenesis (GO:0042273)3.54734142
57regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.52143646
58ribonucleoprotein complex biogenesis (GO:0022613)3.50650167
59regulation of mitotic spindle checkpoint (GO:1903504)3.47719333
60regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.47719333
61establishment of chromosome localization (GO:0051303)3.45173479
62mitotic chromosome condensation (GO:0007076)3.44433862
63synapsis (GO:0007129)3.43364838
64mitotic G2/M transition checkpoint (GO:0044818)3.43296761
65negative regulation of ligase activity (GO:0051352)3.39220058
66negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.39220058
67maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.38680892
68regulation of double-strand break repair via homologous recombination (GO:0010569)3.35284928
69mitotic sister chromatid segregation (GO:0000070)3.35134637
70transcription-coupled nucleotide-excision repair (GO:0006283)3.33709185
71DNA deamination (GO:0045006)3.30614592
72DNA geometric change (GO:0032392)3.30239253
73DNA duplex unwinding (GO:0032508)3.30107441
74meiotic chromosome segregation (GO:0045132)3.28650727
75regulation of nuclear cell cycle DNA replication (GO:0033262)3.28559462
76spliceosomal snRNP assembly (GO:0000387)3.27991849
77mismatch repair (GO:0006298)3.27647283
78translational termination (GO:0006415)3.25436454
79resolution of meiotic recombination intermediates (GO:0000712)3.24677789
80viral transcription (GO:0019083)3.24604174
81regulation of spindle organization (GO:0090224)3.24024235
82DNA topological change (GO:0006265)3.24020154
83proteasome assembly (GO:0043248)3.23857803
84rRNA processing (GO:0006364)3.22793778
85regulation of sister chromatid segregation (GO:0033045)3.22172871
86regulation of mitotic sister chromatid separation (GO:0010965)3.22172871
87regulation of mitotic sister chromatid segregation (GO:0033047)3.22172871
88telomere maintenance (GO:0000723)3.21954278
89telomere organization (GO:0032200)3.21942698
90recombinational repair (GO:0000725)3.20424592
91establishment of integrated proviral latency (GO:0075713)3.19652214
92G1/S transition of mitotic cell cycle (GO:0000082)3.19306960
93cell cycle G1/S phase transition (GO:0044843)3.19306960
94ribosomal small subunit biogenesis (GO:0042274)3.19221932
95double-strand break repair via homologous recombination (GO:0000724)3.19211810
96rRNA modification (GO:0000154)3.18003077
97regulation of centrosome cycle (GO:0046605)3.17823593
98anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.17688083
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16017540
100translational initiation (GO:0006413)3.14950948
101protein neddylation (GO:0045116)3.14667644
102protein K6-linked ubiquitination (GO:0085020)3.13735778
103negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.13660029
104nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.12357258
105rRNA metabolic process (GO:0016072)3.11886992
106negative regulation of DNA recombination (GO:0045910)3.11592495
107regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.10716746
108positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.10550299
109negative regulation of chromosome segregation (GO:0051985)3.08362059
110chromosome segregation (GO:0007059)3.08302207
111negative regulation of mitotic sister chromatid separation (GO:2000816)3.07616414
112negative regulation of mitotic sister chromatid segregation (GO:0033048)3.07616414
113negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.07616414
114negative regulation of sister chromatid segregation (GO:0033046)3.07616414
115pore complex assembly (GO:0046931)3.07466412
116spindle checkpoint (GO:0031577)3.07109268
117establishment of protein localization to mitochondrial membrane (GO:0090151)3.04603096
118positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.04120851
119sister chromatid segregation (GO:0000819)3.02994957
120translational elongation (GO:0006414)3.02838518
121intra-S DNA damage checkpoint (GO:0031573)3.02311983
122histone H2A acetylation (GO:0043968)3.01569274
123regulation of mitotic metaphase/anaphase transition (GO:0030071)3.01525549
124spindle assembly checkpoint (GO:0071173)3.00442561
125postreplication repair (GO:0006301)2.99037490
126negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.98648033
127regulation of chromosome segregation (GO:0051983)2.98072974
128mitotic spindle assembly checkpoint (GO:0007094)2.96823424
129regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.94733865
130spliceosomal complex assembly (GO:0000245)2.94013206
131* chromatin assembly or disassembly (GO:0006333)2.93642164
132positive regulation of chromosome segregation (GO:0051984)2.93523092
133somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.92961231
134somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.92961231
135isotype switching (GO:0045190)2.92961231
136mitotic spindle checkpoint (GO:0071174)2.92591000

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.81082485
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.35564600
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.91478332
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.85613631
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.43789427
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.23301413
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.11378740
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.10071907
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.96252568
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89552947
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.78857877
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.78701774
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.65627216
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.65074918
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.62577974
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.44480497
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.43095505
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.31666347
19* XRN2_22483619_ChIP-Seq_HELA_Human2.22816852
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.21592662
21* AR_21909140_ChIP-Seq_LNCAP_Human2.19260377
22* VDR_23849224_ChIP-Seq_CD4+_Human2.15883745
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.08332853
24* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08092551
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07729497
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07589669
27* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.97548171
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93408400
29DCP1A_22483619_ChIP-Seq_HELA_Human1.92850020
30* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91618697
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.89628837
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.89404253
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89377373
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.88036114
35FOXP3_21729870_ChIP-Seq_TREG_Human1.87183716
36TTF2_22483619_ChIP-Seq_HELA_Human1.77626422
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73786200
38EWS_26573619_Chip-Seq_HEK293_Human1.73174847
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72719677
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71364657
41* GABP_19822575_ChIP-Seq_HepG2_Human1.71094823
42VDR_22108803_ChIP-Seq_LS180_Human1.69967223
43ZNF274_21170338_ChIP-Seq_K562_Hela1.67539939
44* ELK1_19687146_ChIP-ChIP_HELA_Human1.67156074
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60895091
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55159729
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54957131
48* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54507209
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51972500
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.51490413
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50448896
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.49454584
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.49110670
54* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48053361
55SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.47124676
56FUS_26573619_Chip-Seq_HEK293_Human1.46225156
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44804031
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42143281
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38473948
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35601489
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34910837
62KDM5A_27292631_Chip-Seq_BREAST_Human1.34669543
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.32921605
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.31078580
65CIITA_25753668_ChIP-Seq_RAJI_Human1.30686152
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29923484
67IGF1R_20145208_ChIP-Seq_DFB_Human1.25741205
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21907701
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21703385
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18581779
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17505106
72KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.16213469
73KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.16213469
74KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.16213469
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16033245
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.13959267
77NANOG_16153702_ChIP-ChIP_HESCs_Human1.13705187
78TFEB_21752829_ChIP-Seq_HELA_Human1.13337335
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12345584
80* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12334956
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11184806
82* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09818382
83MYC_22102868_ChIP-Seq_BL_Human1.09480278
84TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09245961
85TP63_19390658_ChIP-ChIP_HaCaT_Human1.07944228
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07282383
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06715851
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06642058
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05286461
90IRF1_19129219_ChIP-ChIP_H3396_Human1.02357538
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02069475
92* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01891270
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01313115
94NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00271079
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98682135
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97545981
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95816051
98PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95080265
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94822870
100MYC_18940864_ChIP-ChIP_HL60_Human0.94357937
101ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93567194
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92699180
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91679780
104ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91230807
105* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90487142
106NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.90204436
107P300_19829295_ChIP-Seq_ESCs_Human0.89004928
108SOX2_18692474_ChIP-Seq_MEFs_Mouse0.88095377
109SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.87673356
110DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86780604
111SOX17_20123909_ChIP-Seq_XEN_Mouse0.86703257
112SOX2_16153702_ChIP-ChIP_HESCs_Human0.86486552
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86253785
114EZH2_27294783_Chip-Seq_NPCs_Mouse0.85346266
115OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85161847
116NANOG_21062744_ChIP-ChIP_HESCs_Human0.84498511
117NOTCH1_21737748_ChIP-Seq_TLL_Human0.82885958
118TAF15_26573619_Chip-Seq_HEK293_Human0.82508092
119TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82369956
120* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81906910
121SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80239578
122* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79914678
123SUZ12_27294783_Chip-Seq_NPCs_Mouse0.74539117
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74364776
125* ELK1_22589737_ChIP-Seq_MCF10A_Human0.74150923
126ER_23166858_ChIP-Seq_MCF-7_Human0.73525464
127NFE2_27457419_Chip-Seq_LIVER_Mouse0.71974755
128MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.69432239
129EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.67667691
130TP53_22573176_ChIP-Seq_HFKS_Human0.67106139
131HTT_18923047_ChIP-ChIP_STHdh_Human0.66816209
132SALL4_22934838_ChIP-ChIP_CD34+_Human0.64878324

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.51240140
2MP0010094_abnormal_chromosome_stability5.24800810
3MP0004957_abnormal_blastocyst_morpholog4.71175553
4MP0008057_abnormal_DNA_replication4.68765586
5MP0003111_abnormal_nucleus_morphology4.63485954
6MP0003077_abnormal_cell_cycle4.24287901
7MP0008058_abnormal_DNA_repair3.85261030
8MP0008007_abnormal_cellular_replicative2.95821079
9MP0008932_abnormal_embryonic_tissue2.89177975
10MP0008877_abnormal_DNA_methylation2.73937768
11MP0003123_paternal_imprinting2.52568109
12MP0001730_embryonic_growth_arrest2.42657800
13MP0010352_gastrointestinal_tract_polyps2.41024239
14MP0000350_abnormal_cell_proliferation2.37792528
15MP0003806_abnormal_nucleotide_metabolis2.17218923
16MP0003786_premature_aging2.13937585
17MP0002396_abnormal_hematopoietic_system2.13016123
18MP0010307_abnormal_tumor_latency2.10517183
19MP0006072_abnormal_retinal_apoptosis2.01416064
20MP0002102_abnormal_ear_morphology1.82350667
21MP0005380_embryogenesis_phenotype1.76101345
22MP0001672_abnormal_embryogenesis/_devel1.76101345
23MP0001697_abnormal_embryo_size1.74948189
24MP0003718_maternal_effect1.73572436
25MP0001529_abnormal_vocalization1.69991190
26MP0002080_prenatal_lethality1.58729318
27MP0000490_abnormal_crypts_of1.55883402
28MP0003984_embryonic_growth_retardation1.55812259
29MP0002085_abnormal_embryonic_tissue1.54308251
30MP0002088_abnormal_embryonic_growth/wei1.51699743
31MP0002210_abnormal_sex_determination1.51192430
32MP0000313_abnormal_cell_death1.50729361
33MP0004147_increased_porphyrin_level1.50074775
34MP0002084_abnormal_developmental_patter1.45390550
35MP0002019_abnormal_tumor_incidence1.42123720
36MP0004197_abnormal_fetal_growth/weight/1.41999665
37MP0002086_abnormal_extraembryonic_tissu1.40603197
38MP0003567_abnormal_fetal_cardiomyocyte1.39242346
39MP0000372_irregular_coat_pigmentation1.36291049
40MP0001293_anophthalmia1.35407169
41MP0003890_abnormal_embryonic-extraembry1.35017672
42MP0001145_abnormal_male_reproductive1.31551042
43MP0003941_abnormal_skin_development1.30254882
44MP0002938_white_spotting1.30254024
45MP0003121_genomic_imprinting1.26786295
46MP0003186_abnormal_redox_activity1.25898378
47MP0004808_abnormal_hematopoietic_stem1.24777737
48MP0003315_abnormal_perineum_morphology1.23737833
49MP0004133_heterotaxia1.22597282
50MP0005253_abnormal_eye_physiology1.20175906
51MP0001929_abnormal_gametogenesis1.15386357
52MP0008789_abnormal_olfactory_epithelium1.14227270
53MP0002160_abnormal_reproductive_system1.13631437
54MP0000653_abnormal_sex_gland1.11084278
55MP0005076_abnormal_cell_differentiation1.07493493
56MP0009333_abnormal_splenocyte_physiolog1.05060775
57MP0000647_abnormal_sebaceous_gland1.01639296
58MP0002233_abnormal_nose_morphology0.98468825
59MP0006292_abnormal_olfactory_placode0.98084019
60MP0005084_abnormal_gallbladder_morpholo0.98021379
61MP0002163_abnormal_gland_morphology0.94404710
62MP0005397_hematopoietic_system_phenotyp0.93387870
63MP0001545_abnormal_hematopoietic_system0.93387870
64MP0000703_abnormal_thymus_morphology0.91971840
65MP0003119_abnormal_digestive_system0.91661019
66MP0004215_abnormal_myocardial_fiber0.90849280
67MP0001119_abnormal_female_reproductive0.90824558
68MP0005389_reproductive_system_phenotype0.90678254
69MP0000358_abnormal_cell_content/0.89365657
70MP0002736_abnormal_nociception_after0.88672050
71MP0008995_early_reproductive_senescence0.87230925
72MP0001764_abnormal_homeostasis0.86259108
73MP0002398_abnormal_bone_marrow0.86013394
74MP0002722_abnormal_immune_system0.82939652
75MP0009053_abnormal_anal_canal0.81885246
76MP0002090_abnormal_vision0.81883265
77MP0005379_endocrine/exocrine_gland_phen0.81256261
78MP0005395_other_phenotype0.80811330
79MP0005384_cellular_phenotype0.80767511
80MP0005408_hypopigmentation0.79732151
81MP0010030_abnormal_orbit_morphology0.79521594
82MP0002653_abnormal_ependyma_morphology0.79374579
83MP0000689_abnormal_spleen_morphology0.79367604
84MP0003221_abnormal_cardiomyocyte_apopto0.78003504
85MP0000858_altered_metastatic_potential0.77704694
86MP0003763_abnormal_thymus_physiology0.76515497
87MP0005187_abnormal_penis_morphology0.76022899
88MP0001177_atelectasis0.75858043
89MP0001853_heart_inflammation0.75620520
90MP0003787_abnormal_imprinting0.75106127
91MP0002111_abnormal_tail_morphology0.74204521
92MP0000537_abnormal_urethra_morphology0.73876989
93MP0005621_abnormal_cell_physiology0.73844480
94MP0005266_abnormal_metabolism0.72488775
95MP0002751_abnormal_autonomic_nervous0.72268909
96MP0003136_yellow_coat_color0.71666439
97MP0003943_abnormal_hepatobiliary_system0.71282016
98MP0009672_abnormal_birth_weight0.70454531
99MP0002254_reproductive_system_inflammat0.70133330
100MP0002234_abnormal_pharynx_morphology0.69960865
101MP0002429_abnormal_blood_cell0.69490473
102MP0003937_abnormal_limbs/digits/tail_de0.69000142
103MP0003755_abnormal_palate_morphology0.68297572
104MP0002837_dystrophic_cardiac_calcinosis0.68247970
105MP0005023_abnormal_wound_healing0.68081378
106MP0005391_vision/eye_phenotype0.67308863
107MP0001286_abnormal_eye_development0.67205526
108MP0001915_intracranial_hemorrhage0.65969031
109MP0000427_abnormal_hair_cycle0.65556862
110MP0006036_abnormal_mitochondrial_physio0.64606356
111MP0003566_abnormal_cell_adhesion0.64243291
112MP0003448_altered_tumor_morphology0.64198164
113MP0005075_abnormal_melanosome_morpholog0.63718741
114MP0006054_spinal_hemorrhage0.63222330
115MP0009703_decreased_birth_body0.62056341
116MP0009697_abnormal_copulation0.61956950
117MP0005551_abnormal_eye_electrophysiolog0.61550172
118MP0001919_abnormal_reproductive_system0.59643132
119MP0003698_abnormal_male_reproductive0.59281169
120MP0000631_abnormal_neuroendocrine_gland0.58879458
121MP0006035_abnormal_mitochondrial_morpho0.57890768
122MP0000477_abnormal_intestine_morphology0.56299161
123MP0002092_abnormal_eye_morphology0.54973891
124MP0003936_abnormal_reproductive_system0.54570182
125MP0005367_renal/urinary_system_phenotyp0.53885203
126MP0000516_abnormal_urinary_system0.53885203
127MP0000716_abnormal_immune_system0.53276838
128MP0002075_abnormal_coat/hair_pigmentati0.53197426
129MP0005501_abnormal_skin_physiology0.52655368
130MP0002161_abnormal_fertility/fecundity0.50760778
131MP0003699_abnormal_female_reproductive0.47758586
132MP0002095_abnormal_skin_pigmentation0.46367724
133MP0002132_abnormal_respiratory_system0.44838805
134MP0001835_abnormal_antigen_presentation0.44600743

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.85682003
2Chromsome breakage (HP:0040012)4.56780558
3Breast hypoplasia (HP:0003187)4.43444409
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.33728927
5Reticulocytopenia (HP:0001896)4.24028866
6Colon cancer (HP:0003003)4.09142323
7Oral leukoplakia (HP:0002745)3.89001308
8Agnosia (HP:0010524)3.87358812
9Ependymoma (HP:0002888)3.81178359
10Medulloblastoma (HP:0002885)3.74612981
11Abnormality of chromosome stability (HP:0003220)3.57181697
12Volvulus (HP:0002580)3.47492336
13Abnormality of cells of the erythroid lineage (HP:0012130)3.43951327
14Meckel diverticulum (HP:0002245)3.42899208
15Selective tooth agenesis (HP:0001592)3.37590451
16Carpal bone hypoplasia (HP:0001498)3.37411732
17Patellar aplasia (HP:0006443)3.36824240
18Abnormality of the preputium (HP:0100587)3.34824156
19Abnormality of the anterior horn cell (HP:0006802)3.25492922
20Degeneration of anterior horn cells (HP:0002398)3.25492922
21Abnormality of the ileum (HP:0001549)3.22979653
22Abnormal number of erythroid precursors (HP:0012131)3.20143818
23Absent radius (HP:0003974)3.16841856
24Aplasia/Hypoplasia of the patella (HP:0006498)3.13237266
25Aplasia/Hypoplasia of the uvula (HP:0010293)3.06298215
26Rough bone trabeculation (HP:0100670)3.05181184
27Rhabdomyosarcoma (HP:0002859)3.03509894
28Absent thumb (HP:0009777)3.03214791
29Acute encephalopathy (HP:0006846)3.02045217
30Acute necrotizing encephalopathy (HP:0006965)2.97797221
31Aplasia involving forearm bones (HP:0009822)2.95806678
32Absent forearm bone (HP:0003953)2.95806678
33Abnormality of the labia minora (HP:0012880)2.90503015
34Supernumerary spleens (HP:0009799)2.87899195
35Cerebral hypomyelination (HP:0006808)2.84039536
36Small intestinal stenosis (HP:0012848)2.75766741
37Duodenal stenosis (HP:0100867)2.75766741
38Increased hepatocellular lipid droplets (HP:0006565)2.69665484
39Neoplasm of the pancreas (HP:0002894)2.69247611
40Increased CSF lactate (HP:0002490)2.68763763
41Myelodysplasia (HP:0002863)2.66420447
42Aplastic anemia (HP:0001915)2.65314665
43Impulsivity (HP:0100710)2.63797177
44Bone marrow hypocellularity (HP:0005528)2.61885263
45Macrocytic anemia (HP:0001972)2.61473087
46Abnormal mitochondria in muscle tissue (HP:0008316)2.61130544
47Abnormality of methionine metabolism (HP:0010901)2.58743216
48Premature graying of hair (HP:0002216)2.56219188
49Mitochondrial inheritance (HP:0001427)2.54205367
50Embryonal renal neoplasm (HP:0011794)2.50972662
5111 pairs of ribs (HP:0000878)2.49497927
52Horseshoe kidney (HP:0000085)2.48809549
53Increased serum pyruvate (HP:0003542)2.48763221
54Duplicated collecting system (HP:0000081)2.47454750
55Pallor (HP:0000980)2.45190795
56Lipid accumulation in hepatocytes (HP:0006561)2.44275520
57Progressive macrocephaly (HP:0004481)2.43158518
58Abnormal number of incisors (HP:0011064)2.41351803
59Amaurosis fugax (HP:0100576)2.40453827
60Sloping forehead (HP:0000340)2.38467005
61Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.38419669
62Hyperglycinemia (HP:0002154)2.37757061
63Microretrognathia (HP:0000308)2.35339910
64Ectopic kidney (HP:0000086)2.35262008
65Abnormality of the astrocytes (HP:0100707)2.34629903
66Astrocytoma (HP:0009592)2.34629903
67Glioma (HP:0009733)2.33286214
68Tracheoesophageal fistula (HP:0002575)2.31578586
69Biliary tract neoplasm (HP:0100574)2.29841106
70Triphalangeal thumb (HP:0001199)2.29185322
71Abnormal trabecular bone morphology (HP:0100671)2.28516037
72Abnormality of the duodenum (HP:0002246)2.28474664
73Abnormality of serum amino acid levels (HP:0003112)2.27672738
74Basal cell carcinoma (HP:0002671)2.27377443
75Hepatocellular necrosis (HP:0001404)2.27287884
76Abnormal lung lobation (HP:0002101)2.27247811
77Abnormality of glycolysis (HP:0004366)2.27160084
78Abnormality of aspartate family amino acid metabolism (HP:0010899)2.25403121
79Neoplasm of the oral cavity (HP:0100649)2.24772831
80Cerebral edema (HP:0002181)2.23258295
81Cleft eyelid (HP:0000625)2.22102889
82Type I transferrin isoform profile (HP:0003642)2.19192752
83Increased serum lactate (HP:0002151)2.19145237
84Methylmalonic acidemia (HP:0002912)2.19006938
85Neoplasm of the colon (HP:0100273)2.18545010
86Trismus (HP:0000211)2.17773143
87Cellular immunodeficiency (HP:0005374)2.17615903
88Atresia of the external auditory canal (HP:0000413)2.17032531
89Stenosis of the external auditory canal (HP:0000402)2.16646992
90Asplenia (HP:0001746)2.15652969
91Abnormality of the renal collecting system (HP:0004742)2.15605768
92Proximal placement of thumb (HP:0009623)2.11322383
93Abnormality of alanine metabolism (HP:0010916)2.07288928
94Hyperalaninemia (HP:0003348)2.07288928
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07288928
96Hepatic necrosis (HP:0002605)2.06908137
97Neoplasm of striated muscle (HP:0009728)2.06729303
98Abnormality of the carotid arteries (HP:0005344)2.04123312
99Short thumb (HP:0009778)2.02546423
100Intestinal atresia (HP:0011100)2.01805740
101Deviation of the thumb (HP:0009603)2.01546256
102Premature ovarian failure (HP:0008209)2.00925298
103Pancreatic fibrosis (HP:0100732)1.99501840
104Aplasia/Hypoplasia of the sacrum (HP:0008517)1.99332084
105Abnormality of pyrimidine metabolism (HP:0004353)1.98577787
106Hyperglycinuria (HP:0003108)1.98187484
107Pancreatic islet-cell hyperplasia (HP:0004510)1.97595387
108Clubbing of toes (HP:0100760)1.97405555
109Missing ribs (HP:0000921)1.96768292
110Aplasia/Hypoplasia of the spleen (HP:0010451)1.96280739
111Lymphoma (HP:0002665)1.96049720
112Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94658293
113Abnormal protein N-linked glycosylation (HP:0012347)1.94658293
114Abnormal protein glycosylation (HP:0012346)1.94658293
115Abnormal glycosylation (HP:0012345)1.94658293
116Aplasia/hypoplasia of the humerus (HP:0006507)1.93346199
117True hermaphroditism (HP:0010459)1.92995680
118Lactic acidosis (HP:0003128)1.92646735
119Abnormality of abdominal situs (HP:0011620)1.92167884
120Abdominal situs inversus (HP:0003363)1.92167884
121Cafe-au-lait spot (HP:0000957)1.92057187
122Pancreatic cysts (HP:0001737)1.91671234
123Abnormality of glycine metabolism (HP:0010895)1.91270109
124Abnormality of serine family amino acid metabolism (HP:0010894)1.91270109
125Ovarian neoplasm (HP:0100615)1.90574675
126Pancytopenia (HP:0001876)1.90057670
127Slender long bone (HP:0003100)1.88494753
128Multiple enchondromatosis (HP:0005701)1.87586535
129Increased nuchal translucency (HP:0010880)1.85241012
130Squamous cell carcinoma (HP:0002860)1.85119000
131Median cleft lip (HP:0000161)1.84444332
132Abnormal spermatogenesis (HP:0008669)1.84285622
133Atrophy/Degeneration involving motor neurons (HP:0007373)1.83547647
134Microvesicular hepatic steatosis (HP:0001414)1.83240180
135Aplasia/Hypoplasia of the sternum (HP:0006714)1.83216188
136Nephroblastoma (Wilms tumor) (HP:0002667)1.82149015
137Renal Fanconi syndrome (HP:0001994)1.82050186
138Secondary amenorrhea (HP:0000869)1.79177869
139Neoplasm of the rectum (HP:0100743)1.78646629
140Abnormality of midbrain morphology (HP:0002418)1.78530302
141Molar tooth sign on MRI (HP:0002419)1.78530302
142Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78478650
143Gonadotropin excess (HP:0000837)1.77777243
144Reduced antithrombin III activity (HP:0001976)1.77071677
145Megaloblastic anemia (HP:0001889)1.76390871
146Methylmalonic aciduria (HP:0012120)1.76279563
147Hypoplastic pelvis (HP:0008839)1.75931500
148Bifid tongue (HP:0010297)1.73958799
149Astigmatism (HP:0000483)1.67390433
150Postnatal microcephaly (HP:0005484)1.67370371
151Hypoplasia of the pons (HP:0012110)1.66216088
152Small hand (HP:0200055)1.64243920
153Cortical dysplasia (HP:0002539)1.63958909
154Neoplasm of the adrenal gland (HP:0100631)1.63238720
155Abnormality of the pons (HP:0007361)1.63130341
156Choanal atresia (HP:0000453)1.61514528
157Respiratory failure (HP:0002878)1.61316978

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.69849339
2CDC74.61682015
3BUB14.15723038
4EIF2AK13.65120967
5NEK13.33547764
6NEK22.76666694
7SRPK12.74612757
8ACVR1B2.73568320
9TTK2.51519595
10TRIM282.39923041
11PLK42.38675233
12TSSK62.33635947
13BRSK22.27594660
14EIF2AK32.21661642
15VRK22.13664738
16PLK12.11946372
17NUAK11.96125101
18NME21.90691959
19VRK11.90213103
20MKNK11.89558856
21ATR1.80830141
22PLK31.73716435
23PASK1.71103463
24AURKB1.70929857
25CDK71.69113823
26STK161.66534113
27RPS6KB21.64631152
28EPHA21.57811258
29BMPR1B1.56454096
30TLK11.53931461
31CHEK21.47587914
32WNK31.45355532
33PBK1.45070181
34TESK21.44192350
35CDK121.39324838
36MAP4K21.35614166
37DYRK31.34287257
38MKNK21.33044431
39BRSK11.32067614
40SCYL21.28424184
41ERBB31.27615993
42AURKA1.25922290
43RPS6KA41.25442914
44CHEK11.24997620
45PLK21.22192107
46TAF11.21788780
47MAP3K81.20756263
48CCNB11.20163664
49CDK41.17497880
50TNIK1.15799850
51ZAK1.14190301
52TGFBR11.12513231
53STK41.09652159
54PNCK1.06424609
55PAK40.98703822
56FRK0.97339219
57ATM0.97241709
58STK100.92248254
59STK390.88821211
60EIF2AK20.87221912
61CDK20.85713300
62FLT30.85042699
63MST40.84535489
64CSNK1G10.83699406
65CSNK2A20.76711518
66PIM10.76710237
67CSNK2A10.74732748
68CSNK1G30.74393632
69BRD40.72803377
70MAP3K40.70918047
71ALK0.68821123
72CSNK1G20.65374696
73CDK60.65222353
74MAPKAPK30.65053462
75CDK10.64740198
76MELK0.64613358
77TESK10.63749012
78BRAF0.62978149
79STK38L0.60148487
80CSNK1A1L0.57078649
81PRKCI0.56107917
82RPS6KA50.55912902
83ERBB40.55381765
84PAK10.54577114
85CDK80.53416720
86OXSR10.53331794
87PIM20.52225173
88MAP3K120.51823428
89KDR0.46960084
90PDK30.44682372
91PDK40.44682372
92FGFR10.42555418
93EEF2K0.41610629
94CLK10.41304127
95CDK30.39076074
96GRK10.38881635
97INSRR0.38144878
98PRKDC0.36333077
99DYRK20.34288432
100BCKDK0.33867255
101CSNK1E0.33158998
102LRRK20.32516787
103STK30.32141946
104NME10.31412159
105MAPK130.31180854
106MAP2K70.30212735
107YES10.29673509
108AKT30.27745616
109PDK20.27625558
110NEK90.27120284
111CSNK1D0.26819515
112DAPK10.26489854
113MAP2K30.25889263
114PINK10.25190051
115IRAK40.23932368
116SIK30.23812031
117MAP3K100.23494967
118MINK10.23174900
119MAPKAPK50.23016297
120MAP3K110.22435903
121LATS10.22369298
122WNK40.21318763
123TEC0.20565680
124LIMK10.20024365
125MAPK140.19832842
126CSNK1A10.18612101
127MET0.18097846
128CDK140.17633675
129AKT20.17326568
130BCR0.16278755
131TAOK20.16113414
132MAP3K30.15003140
133IKBKB0.14846052
134AKT10.14605679

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.45539214
2Mismatch repair_Homo sapiens_hsa034304.91376950
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.70717687
4Proteasome_Homo sapiens_hsa030503.59455989
5Homologous recombination_Homo sapiens_hsa034403.29729658
6Spliceosome_Homo sapiens_hsa030403.27535440
7Ribosome_Homo sapiens_hsa030103.25614835
8RNA polymerase_Homo sapiens_hsa030203.14947213
9RNA transport_Homo sapiens_hsa030133.10551787
10Nucleotide excision repair_Homo sapiens_hsa034203.09740833
11Base excision repair_Homo sapiens_hsa034103.08495996
12One carbon pool by folate_Homo sapiens_hsa006702.77394530
13Cell cycle_Homo sapiens_hsa041102.72959853
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.50303474
15Pyrimidine metabolism_Homo sapiens_hsa002402.47842334
16Fanconi anemia pathway_Homo sapiens_hsa034602.41208651
17Non-homologous end-joining_Homo sapiens_hsa034502.24963086
18Propanoate metabolism_Homo sapiens_hsa006402.03252822
19Basal transcription factors_Homo sapiens_hsa030221.97069478
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88140836
21RNA degradation_Homo sapiens_hsa030181.87146874
22mRNA surveillance pathway_Homo sapiens_hsa030151.61041015
23p53 signaling pathway_Homo sapiens_hsa041151.57144749
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42429236
25Steroid biosynthesis_Homo sapiens_hsa001001.41528887
26Pyruvate metabolism_Homo sapiens_hsa006201.38224603
27Purine metabolism_Homo sapiens_hsa002301.32897016
28Fatty acid elongation_Homo sapiens_hsa000621.31702550
29Epstein-Barr virus infection_Homo sapiens_hsa051691.19425788
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18430687
31Systemic lupus erythematosus_Homo sapiens_hsa053221.11943843
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93900338
33Butanoate metabolism_Homo sapiens_hsa006500.93518559
34Oocyte meiosis_Homo sapiens_hsa041140.91255713
35Antigen processing and presentation_Homo sapiens_hsa046120.90896392
36Herpes simplex infection_Homo sapiens_hsa051680.90457673
37Alzheimers disease_Homo sapiens_hsa050100.89510327
38Folate biosynthesis_Homo sapiens_hsa007900.86519694
39Viral carcinogenesis_Homo sapiens_hsa052030.86503682
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83117366
41Biosynthesis of amino acids_Homo sapiens_hsa012300.78223901
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.77802269
43Pentose phosphate pathway_Homo sapiens_hsa000300.73115294
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69998426
45Fatty acid metabolism_Homo sapiens_hsa012120.68749759
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.67487701
47Selenocompound metabolism_Homo sapiens_hsa004500.67351331
48Huntingtons disease_Homo sapiens_hsa050160.66882610
49Protein export_Homo sapiens_hsa030600.65747017
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.63951155
51HTLV-I infection_Homo sapiens_hsa051660.63292252
52Legionellosis_Homo sapiens_hsa051340.61302383
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60533547
54Glutathione metabolism_Homo sapiens_hsa004800.59537766
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56465322
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55343092
57beta-Alanine metabolism_Homo sapiens_hsa004100.54393678
58Peroxisome_Homo sapiens_hsa041460.50214290
59Parkinsons disease_Homo sapiens_hsa050120.49591752
60Carbon metabolism_Homo sapiens_hsa012000.48467922
61Nitrogen metabolism_Homo sapiens_hsa009100.48343466
62Fatty acid degradation_Homo sapiens_hsa000710.48063905
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47915914
64Sulfur metabolism_Homo sapiens_hsa009200.47318187
65Phototransduction_Homo sapiens_hsa047440.46662253
66Thyroid cancer_Homo sapiens_hsa052160.45451053
67MicroRNAs in cancer_Homo sapiens_hsa052060.44255088
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43075885
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41944582
70Small cell lung cancer_Homo sapiens_hsa052220.39754624
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39230594
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37986148
73Vitamin B6 metabolism_Homo sapiens_hsa007500.37686289
74Regulation of autophagy_Homo sapiens_hsa041400.37511691
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36611003
76Caffeine metabolism_Homo sapiens_hsa002320.36510788
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35919617
78Tryptophan metabolism_Homo sapiens_hsa003800.35790016
79Fructose and mannose metabolism_Homo sapiens_hsa000510.35477752
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35271220
81Apoptosis_Homo sapiens_hsa042100.35054431
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35048185
83TGF-beta signaling pathway_Homo sapiens_hsa043500.32494157
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32161008
85Allograft rejection_Homo sapiens_hsa053300.31535078
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30741241
87Measles_Homo sapiens_hsa051620.30183470
88Hippo signaling pathway_Homo sapiens_hsa043900.29039521
89Sulfur relay system_Homo sapiens_hsa041220.28579587
90Oxidative phosphorylation_Homo sapiens_hsa001900.27610994
91Primary immunodeficiency_Homo sapiens_hsa053400.25507432
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24931614
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.24682871
94* Alcoholism_Homo sapiens_hsa050340.23704265
95Arginine and proline metabolism_Homo sapiens_hsa003300.23311182
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23266776
97Shigellosis_Homo sapiens_hsa051310.21445131
98Colorectal cancer_Homo sapiens_hsa052100.21164113
99Metabolic pathways_Homo sapiens_hsa011000.21062119
100Influenza A_Homo sapiens_hsa051640.20838679
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20270411
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.19567318
103Olfactory transduction_Homo sapiens_hsa047400.19016995
104Hepatitis B_Homo sapiens_hsa051610.18855335
105Basal cell carcinoma_Homo sapiens_hsa052170.18783284
106HIF-1 signaling pathway_Homo sapiens_hsa040660.18592733
107Graft-versus-host disease_Homo sapiens_hsa053320.18149027
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18107326
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.17955298
110Galactose metabolism_Homo sapiens_hsa000520.17354340
111Lysine degradation_Homo sapiens_hsa003100.17353272
112Chemical carcinogenesis_Homo sapiens_hsa052040.17140658
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16789652
114Arachidonic acid metabolism_Homo sapiens_hsa005900.16441941
115Asthma_Homo sapiens_hsa053100.15473494
116Renin-angiotensin system_Homo sapiens_hsa046140.14949367
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14632380
118Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.14569124
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.14441475
120Pathways in cancer_Homo sapiens_hsa052000.14168557
121Cardiac muscle contraction_Homo sapiens_hsa042600.13646569
122Retinol metabolism_Homo sapiens_hsa008300.13049081
123Viral myocarditis_Homo sapiens_hsa054160.12749314
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.12578811
125Notch signaling pathway_Homo sapiens_hsa043300.12571710
126Type I diabetes mellitus_Homo sapiens_hsa049400.12222404
127N-Glycan biosynthesis_Homo sapiens_hsa005100.11996824
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.11194003
129Hematopoietic cell lineage_Homo sapiens_hsa046400.10105328
130Autoimmune thyroid disease_Homo sapiens_hsa053200.09638010
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.09585655
132Bladder cancer_Homo sapiens_hsa052190.09029566
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.08304337
134Fat digestion and absorption_Homo sapiens_hsa049750.07827464
135Wnt signaling pathway_Homo sapiens_hsa043100.07707125
136Adherens junction_Homo sapiens_hsa045200.07081244
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.05317716
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.04819743
139Vitamin digestion and absorption_Homo sapiens_hsa049770.04806763

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