HAUS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HAUS1 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.99169159
2telomere maintenance via semi-conservative replication (GO:0032201)4.82524934
3DNA strand elongation (GO:0022616)4.73705484
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.63724616
5DNA replication initiation (GO:0006270)4.63567028
6ribosomal small subunit assembly (GO:0000028)4.56458891
7CENP-A containing nucleosome assembly (GO:0034080)4.52988019
8chromatin remodeling at centromere (GO:0031055)4.50051903
9telomere maintenance via recombination (GO:0000722)4.40242340
10DNA replication checkpoint (GO:0000076)4.40232082
11nucleobase biosynthetic process (GO:0046112)4.30032374
12DNA double-strand break processing (GO:0000729)4.28165207
13purine nucleobase biosynthetic process (GO:0009113)4.21953557
14chaperone-mediated protein transport (GO:0072321)4.20044827
15mitotic metaphase plate congression (GO:0007080)4.16923497
16mitotic recombination (GO:0006312)4.14461419
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.13037880
18DNA deamination (GO:0045006)4.12295794
19energy coupled proton transport, down electrochemical gradient (GO:0015985)4.08737461
20ATP synthesis coupled proton transport (GO:0015986)4.08737461
21maturation of SSU-rRNA (GO:0030490)4.06008275
22protein localization to kinetochore (GO:0034501)3.95146672
23kinetochore organization (GO:0051383)3.94171954
24DNA replication-independent nucleosome assembly (GO:0006336)3.94025236
25DNA replication-independent nucleosome organization (GO:0034724)3.94025236
26formation of translation preinitiation complex (GO:0001731)3.90195931
27DNA unwinding involved in DNA replication (GO:0006268)3.88621311
28histone exchange (GO:0043486)3.86157561
29protein neddylation (GO:0045116)3.82945115
30telomere maintenance via telomere lengthening (GO:0010833)3.79145560
31ribosomal large subunit biogenesis (GO:0042273)3.76337293
32DNA ligation (GO:0006266)3.76130887
33DNA replication-dependent nucleosome assembly (GO:0006335)3.71666407
34DNA replication-dependent nucleosome organization (GO:0034723)3.71666407
35nucleotide-excision repair, DNA gap filling (GO:0006297)3.71409039
36proteasome assembly (GO:0043248)3.69922783
37metaphase plate congression (GO:0051310)3.69743214
38exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.65475635
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.64019327
40kinetochore assembly (GO:0051382)3.62567188
41negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.60812661
42replication fork processing (GO:0031297)3.53454589
43IMP biosynthetic process (GO:0006188)3.52722402
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.52688367
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.52344877
46protein localization to chromosome, centromeric region (GO:0071459)3.52079990
47negative regulation of DNA-dependent DNA replication (GO:2000104)3.50161523
48ribonucleoprotein complex biogenesis (GO:0022613)3.49225947
49attachment of spindle microtubules to kinetochore (GO:0008608)3.48246083
50ribosome biogenesis (GO:0042254)3.48094955
51viral transcription (GO:0019083)3.47378845
52translational termination (GO:0006415)3.47005285
53spliceosomal snRNP assembly (GO:0000387)3.45071554
54positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.43767771
55ribosomal small subunit biogenesis (GO:0042274)3.42448164
56establishment of chromosome localization (GO:0051303)3.40380556
57deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.38765710
58mitotic nuclear envelope disassembly (GO:0007077)3.37911609
59transcription-coupled nucleotide-excision repair (GO:0006283)3.37617432
60DNA catabolic process, exonucleolytic (GO:0000738)3.36791834
61regulation of mitotic spindle checkpoint (GO:1903504)3.33043949
62regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.33043949
63rRNA modification (GO:0000154)3.32731379
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.32293247
65negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.31163490
66negative regulation of ligase activity (GO:0051352)3.31163490
67rRNA processing (GO:0006364)3.30497403
68viral mRNA export from host cell nucleus (GO:0046784)3.29907187
69mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.29184964
70translational elongation (GO:0006414)3.28919580
71mitochondrial respiratory chain complex assembly (GO:0033108)3.28416955
72protein complex biogenesis (GO:0070271)3.27927232
73somatic hypermutation of immunoglobulin genes (GO:0016446)3.25661134
74somatic diversification of immune receptors via somatic mutation (GO:0002566)3.25661134
75regulation of helicase activity (GO:0051095)3.24632149
76establishment of integrated proviral latency (GO:0075713)3.24584345
77cell cycle G1/S phase transition (GO:0044843)3.22146062
78G1/S transition of mitotic cell cycle (GO:0000082)3.22146062
79DNA damage response, detection of DNA damage (GO:0042769)3.21764218
80ribosome assembly (GO:0042255)3.21602210
81cullin deneddylation (GO:0010388)3.20786544
82mitotic sister chromatid segregation (GO:0000070)3.20093326
83rRNA metabolic process (GO:0016072)3.19681400
84establishment of viral latency (GO:0019043)3.18251838
85respiratory chain complex IV assembly (GO:0008535)3.17741944
86translational initiation (GO:0006413)3.16771071
87IMP metabolic process (GO:0046040)3.14862380
88regulation of mitochondrial translation (GO:0070129)3.13476209
89mitochondrial respiratory chain complex I assembly (GO:0032981)3.13381586
90NADH dehydrogenase complex assembly (GO:0010257)3.13381586
91mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.13381586
92mitotic chromosome condensation (GO:0007076)3.13183390
93nuclear pore organization (GO:0006999)3.13013355
94double-strand break repair via nonhomologous end joining (GO:0006303)3.12201284
95non-recombinational repair (GO:0000726)3.12201284
96DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.11222563
97pseudouridine synthesis (GO:0001522)3.08677327
98respiratory electron transport chain (GO:0022904)3.08204867
99signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.08090332
100intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.08090332
101histone mRNA metabolic process (GO:0008334)3.08072321
102protein deneddylation (GO:0000338)3.08069946
103deoxyribonucleotide biosynthetic process (GO:0009263)3.08061316
104meiotic chromosome segregation (GO:0045132)3.07820440
105nuclear envelope disassembly (GO:0051081)3.07015570
106membrane disassembly (GO:0030397)3.07015570
107negative regulation of mitotic sister chromatid segregation (GO:0033048)3.06824525
108negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.06824525
109negative regulation of sister chromatid segregation (GO:0033046)3.06824525
110negative regulation of mitotic sister chromatid separation (GO:2000816)3.06824525
111tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.06443291
112RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.06443291
113signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.06338420
114signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.06338420
115signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.06338420
116DNA strand renaturation (GO:0000733)3.06207822
117transcription elongation from RNA polymerase III promoter (GO:0006385)3.06100560
118termination of RNA polymerase III transcription (GO:0006386)3.06100560
119spindle checkpoint (GO:0031577)3.05664399
120SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.05161733
121negative regulation of chromosome segregation (GO:0051985)3.04828201
1227-methylguanosine mRNA capping (GO:0006370)3.04737981
123positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.03291874
124telomere organization (GO:0032200)3.01885105
125maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.01658299
126telomere maintenance (GO:0000723)3.01469497
127signal transduction involved in DNA integrity checkpoint (GO:0072401)3.01369784
128signal transduction involved in DNA damage checkpoint (GO:0072422)3.01369784
129electron transport chain (GO:0022900)3.01173855
130histone H2A acetylation (GO:0043968)2.99055630
131regulation of double-strand break repair via homologous recombination (GO:0010569)2.99005085
1327-methylguanosine RNA capping (GO:0009452)2.98850059
133RNA capping (GO:0036260)2.98850059
134negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.97922019
135cotranslational protein targeting to membrane (GO:0006613)2.97841197
136signal transduction involved in cell cycle checkpoint (GO:0072395)2.97371780
137regulation of nuclear cell cycle DNA replication (GO:0033262)2.96694687
138mitotic spindle checkpoint (GO:0071174)2.96512914
139regulation of cellular amino acid metabolic process (GO:0006521)2.95723012
140protein K6-linked ubiquitination (GO:0085020)2.93974115

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.37989648
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.33847682
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.82524778
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.76490607
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.58936918
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.56485425
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.41819023
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.27826748
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.18941248
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.18564692
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.98453290
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.96542223
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.94805800
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.91612214
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88027064
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.78284003
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.67978512
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.67291410
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.58107895
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.40077013
21VDR_23849224_ChIP-Seq_CD4+_Human2.34353334
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.33341908
23XRN2_22483619_ChIP-Seq_HELA_Human2.30224353
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18270742
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14531702
26FOXP3_21729870_ChIP-Seq_TREG_Human2.14322941
27AR_21909140_ChIP-Seq_LNCAP_Human2.13580641
28DCP1A_22483619_ChIP-Seq_HELA_Human2.09464868
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.01533988
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.97444981
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96298332
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.95604048
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.95264977
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.95062600
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.92755514
36GABP_19822575_ChIP-Seq_HepG2_Human1.92656886
37TTF2_22483619_ChIP-Seq_HELA_Human1.90036490
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88360893
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87090624
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.84228078
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.83366342
42ELK1_19687146_ChIP-ChIP_HELA_Human1.82538189
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78378999
44ZNF274_21170338_ChIP-Seq_K562_Hela1.76061702
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74828550
46EWS_26573619_Chip-Seq_HEK293_Human1.72974242
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.71498126
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.69625444
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.68096063
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67414038
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65532702
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65343929
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60857211
54KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.57135222
55FUS_26573619_Chip-Seq_HEK293_Human1.53469615
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50857641
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50262436
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47269022
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.45891367
60VDR_22108803_ChIP-Seq_LS180_Human1.43827900
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42825891
62IRF1_19129219_ChIP-ChIP_H3396_Human1.41647789
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37470809
64CIITA_25753668_ChIP-Seq_RAJI_Human1.37434453
65SOX2_16153702_ChIP-ChIP_HESCs_Human1.36650232
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33931172
67IGF1R_20145208_ChIP-Seq_DFB_Human1.33694960
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32115910
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30755400
70KDM5A_27292631_Chip-Seq_BREAST_Human1.29448932
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26095973
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25038418
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.21151690
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19882653
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17598374
76ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14604878
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13024482
78MYC_18940864_ChIP-ChIP_HL60_Human1.11438093
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08681735
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05556166
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05396134
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04243154
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02486573
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01533302
85TAF15_26573619_Chip-Seq_HEK293_Human1.00051486
86TFEB_21752829_ChIP-Seq_HELA_Human0.99718491
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98108634
88SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98001813
89P300_19829295_ChIP-Seq_ESCs_Human0.97437546
90CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96521081
91TP63_19390658_ChIP-ChIP_HaCaT_Human0.96258963
92SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94670067
93EGR1_19374776_ChIP-ChIP_THP-1_Human0.94396813
94PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92635589
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.92490179
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92117411
97NOTCH1_21737748_ChIP-Seq_TLL_Human0.91218759
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90747975
99CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89484100
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87982668
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86745637
102HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86620278
103CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86218376
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86185105
105EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.84325762
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83128674
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82864095
108SPI1_23547873_ChIP-Seq_NB4_Human0.82096298
109SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.78409561
110TP53_22573176_ChIP-Seq_HFKS_Human0.76402171
111GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.76171838
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75814257
113CTBP1_25329375_ChIP-Seq_LNCAP_Human0.75430357
114ZFP57_27257070_Chip-Seq_ESCs_Mouse0.75070718
115NANOG_21062744_ChIP-ChIP_HESCs_Human0.75002201
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.73807164
117SOX17_20123909_ChIP-Seq_XEN_Mouse0.73132472
118MYC_22102868_ChIP-Seq_BL_Human0.72213493
119TBX5_21415370_ChIP-Seq_HL-1_Mouse0.71433543
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.71365032
121FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.71315704
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.70228100
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.70098152
124CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.69874535
125CTBP2_25329375_ChIP-Seq_LNCAP_Human0.69827748
126NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.68679250
127CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.68485960
128FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67532611
129SOX2_18692474_ChIP-Seq_MEFs_Mouse0.67204585

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.66383468
2MP0010094_abnormal_chromosome_stability4.98743644
3MP0004957_abnormal_blastocyst_morpholog4.50203681
4MP0008057_abnormal_DNA_replication4.44280613
5MP0003111_abnormal_nucleus_morphology4.38298624
6MP0003077_abnormal_cell_cycle4.09886161
7MP0008058_abnormal_DNA_repair3.83114015
8MP0008877_abnormal_DNA_methylation3.15780697
9MP0008007_abnormal_cellular_replicative3.09981131
10MP0008932_abnormal_embryonic_tissue2.86216989
11MP0003123_paternal_imprinting2.63485553
12MP0002396_abnormal_hematopoietic_system2.33630801
13MP0003786_premature_aging2.22813635
14MP0001730_embryonic_growth_arrest2.14369076
15MP0003806_abnormal_nucleotide_metabolis2.09096641
16MP0000350_abnormal_cell_proliferation1.96599394
17MP0008789_abnormal_olfactory_epithelium1.88371054
18MP0006072_abnormal_retinal_apoptosis1.78313361
19MP0003136_yellow_coat_color1.72562966
20MP0010352_gastrointestinal_tract_polyps1.72050640
21MP0003718_maternal_effect1.71505434
22MP0002210_abnormal_sex_determination1.69480151
23MP0001929_abnormal_gametogenesis1.60754693
24MP0002736_abnormal_nociception_after1.57026252
25MP0003315_abnormal_perineum_morphology1.56071029
26MP0001697_abnormal_embryo_size1.54851913
27MP0005380_embryogenesis_phenotype1.54705149
28MP0001672_abnormal_embryogenesis/_devel1.54705149
29MP0009697_abnormal_copulation1.52931308
30MP0000490_abnormal_crypts_of1.50492774
31MP0001145_abnormal_male_reproductive1.47433914
32MP0003186_abnormal_redox_activity1.45954902
33MP0000313_abnormal_cell_death1.44999322
34MP0005394_taste/olfaction_phenotype1.44602196
35MP0005499_abnormal_olfactory_system1.44602196
36MP0004808_abnormal_hematopoietic_stem1.43826636
37MP0002080_prenatal_lethality1.43487256
38MP0005410_abnormal_fertilization1.40030227
39MP0003121_genomic_imprinting1.38486115
40MP0010307_abnormal_tumor_latency1.38283596
41MP0003984_embryonic_growth_retardation1.38171820
42MP0002088_abnormal_embryonic_growth/wei1.34292458
43MP0002019_abnormal_tumor_incidence1.30716883
44MP0001188_hyperpigmentation1.30051602
45MP0006036_abnormal_mitochondrial_physio1.29220594
46MP0000653_abnormal_sex_gland1.28642101
47MP0001286_abnormal_eye_development1.27890505
48MP0002160_abnormal_reproductive_system1.27341713
49MP0002085_abnormal_embryonic_tissue1.25471331
50MP0005084_abnormal_gallbladder_morpholo1.24879750
51MP0003567_abnormal_fetal_cardiomyocyte1.24681900
52MP0005397_hematopoietic_system_phenotyp1.22658547
53MP0001545_abnormal_hematopoietic_system1.22658547
54MP0000049_abnormal_middle_ear1.20011126
55MP0008995_early_reproductive_senescence1.18931030
56MP0002234_abnormal_pharynx_morphology1.18533350
57MP0002751_abnormal_autonomic_nervous1.18054350
58MP0003787_abnormal_imprinting1.15758580
59MP0002086_abnormal_extraembryonic_tissu1.12893932
60MP0002132_abnormal_respiratory_system1.12010007
61MP0001485_abnormal_pinna_reflex1.11626466
62MP0002233_abnormal_nose_morphology1.11259045
63MP0003698_abnormal_male_reproductive1.11211651
64MP0005253_abnormal_eye_physiology1.10164954
65MP0004197_abnormal_fetal_growth/weight/1.09597082
66MP0006292_abnormal_olfactory_placode1.09483204
67MP0009333_abnormal_splenocyte_physiolog1.09057118
68MP0002084_abnormal_developmental_patter1.08756284
69MP0001293_anophthalmia1.07426107
70MP0005389_reproductive_system_phenotype1.07081366
71MP0004133_heterotaxia1.05191608
72MP0009379_abnormal_foot_pigmentation1.04621706
73MP0001119_abnormal_female_reproductive1.03513833
74MP0003880_abnormal_central_pattern1.03459569
75MP0003941_abnormal_skin_development1.01699396
76MP0003763_abnormal_thymus_physiology0.99957268
77MP0005075_abnormal_melanosome_morpholog0.98700205
78MP0002697_abnormal_eye_size0.96505203
79MP0000631_abnormal_neuroendocrine_gland0.95694753
80MP0010030_abnormal_orbit_morphology0.93203735
81MP0006035_abnormal_mitochondrial_morpho0.92917806
82MP0000358_abnormal_cell_content/0.91288422
83MP0000703_abnormal_thymus_morphology0.90925970
84MP0002837_dystrophic_cardiac_calcinosis0.90397656
85MP0002938_white_spotting0.90079633
86MP0003195_calcinosis0.89558962
87MP0004147_increased_porphyrin_level0.89313967
88MP0005391_vision/eye_phenotype0.87638407
89MP0000647_abnormal_sebaceous_gland0.86676752
90MP0003890_abnormal_embryonic-extraembry0.86023033
91MP0005551_abnormal_eye_electrophysiolog0.85184283
92MP0002398_abnormal_bone_marrow0.84982795
93MP0001968_abnormal_touch/_nociception0.84124204
94MP0000689_abnormal_spleen_morphology0.82800185
95MP0002722_abnormal_immune_system0.81642441
96MP0008872_abnormal_physiological_respon0.81520520
97MP0002163_abnormal_gland_morphology0.80957030
98MP0001764_abnormal_homeostasis0.80699930
99MP0001346_abnormal_lacrimal_gland0.79895892
100MP0001984_abnormal_olfaction0.79153809
101MP0003011_delayed_dark_adaptation0.78741770
102MP0003221_abnormal_cardiomyocyte_apopto0.78219535
103MP0001919_abnormal_reproductive_system0.76939019
104MP0002161_abnormal_fertility/fecundity0.76068400
105MP0001324_abnormal_eye_pigmentation0.75900221
106MP0001853_heart_inflammation0.73730899
107MP0002095_abnormal_skin_pigmentation0.73317458
108MP0002102_abnormal_ear_morphology0.73176302
109MP0005195_abnormal_posterior_eye0.72245203
110MP0006054_spinal_hemorrhage0.71452066
111MP0006276_abnormal_autonomic_nervous0.71363368
112MP0005266_abnormal_metabolism0.71072853
113MP0003861_abnormal_nervous_system0.70578263
114MP0001986_abnormal_taste_sensitivity0.69947908
115MP0002090_abnormal_vision0.69444684
116MP0005395_other_phenotype0.68818897
117MP0002429_abnormal_blood_cell0.68686716
118MP0005384_cellular_phenotype0.67098060
119MP0003950_abnormal_plasma_membrane0.66422382
120MP0003119_abnormal_digestive_system0.66077101
121MP0004084_abnormal_cardiac_muscle0.65546682
122MP0002111_abnormal_tail_morphology0.64388540
123MP0000372_irregular_coat_pigmentation0.64127995
124MP0000015_abnormal_ear_pigmentation0.63539460
125MP0000566_synostosis0.62539929
126MP0000858_altered_metastatic_potential0.60890921
127MP0005174_abnormal_tail_pigmentation0.58536155
128MP0005408_hypopigmentation0.58260979
129MP0001529_abnormal_vocalization0.56766441
130MP0002653_abnormal_ependyma_morphology0.56006506
131MP0002127_abnormal_cardiovascular_syste0.55277170
132MP0000716_abnormal_immune_system0.50142322
133MP0009672_abnormal_birth_weight0.49564073
134MP0003937_abnormal_limbs/digits/tail_de0.49547458
135MP0005621_abnormal_cell_physiology0.49176448
136MP0003699_abnormal_female_reproductive0.48200054
137MP0002075_abnormal_coat/hair_pigmentati0.47319766

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.26656236
2Abnormality of cells of the erythroid lineage (HP:0012130)4.16013870
3Reticulocytopenia (HP:0001896)4.14032836
4Abnormal number of erythroid precursors (HP:0012131)3.91927723
5Breast hypoplasia (HP:0003187)3.81882462
6Chromsome breakage (HP:0040012)3.67147753
7Aplastic anemia (HP:0001915)3.60947110
8Acute encephalopathy (HP:0006846)3.60643943
9Degeneration of anterior horn cells (HP:0002398)3.52645670
10Abnormality of the anterior horn cell (HP:0006802)3.52645670
11Abnormality of the labia minora (HP:0012880)3.52499676
12Colon cancer (HP:0003003)3.40191764
13Oral leukoplakia (HP:0002745)3.38905041
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.28570581
15Progressive macrocephaly (HP:0004481)3.25079986
16Carpal bone hypoplasia (HP:0001498)3.22766915
17Meckel diverticulum (HP:0002245)3.14321596
1811 pairs of ribs (HP:0000878)3.12209631
19Selective tooth agenesis (HP:0001592)3.11627895
20Patellar aplasia (HP:0006443)3.07200501
21Abnormality of chromosome stability (HP:0003220)3.05875745
22Medulloblastoma (HP:0002885)3.04255361
23Abnormality of the ileum (HP:0001549)2.98517089
24Abnormality of the preputium (HP:0100587)2.97274118
25Aplasia/Hypoplasia of the patella (HP:0006498)2.82309778
26Cerebral hypomyelination (HP:0006808)2.81908113
27Macrocytic anemia (HP:0001972)2.78182280
28Rough bone trabeculation (HP:0100670)2.77872262
29Abnormal lung lobation (HP:0002101)2.76733503
30Supernumerary spleens (HP:0009799)2.71389562
31Hyperglycinemia (HP:0002154)2.70317763
32Renal Fanconi syndrome (HP:0001994)2.69476619
33Cerebral edema (HP:0002181)2.67338986
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.66301304
35Methylmalonic acidemia (HP:0002912)2.65827228
36Absent thumb (HP:0009777)2.64909358
37Septo-optic dysplasia (HP:0100842)2.62337563
38Agnosia (HP:0010524)2.60555251
39Decreased activity of mitochondrial respiratory chain (HP:0008972)2.59672836
40Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.59672836
41Impulsivity (HP:0100710)2.59416992
42Microvesicular hepatic steatosis (HP:0001414)2.57916455
43Pallor (HP:0000980)2.57058624
44Premature graying of hair (HP:0002216)2.55810731
45Bone marrow hypocellularity (HP:0005528)2.54052665
46Hepatocellular necrosis (HP:0001404)2.52048828
47Small intestinal stenosis (HP:0012848)2.51589277
48Duodenal stenosis (HP:0100867)2.51589277
49Pancreatic fibrosis (HP:0100732)2.51142221
50Myelodysplasia (HP:0002863)2.51117432
51Increased serum lactate (HP:0002151)2.44437831
52Aplasia/Hypoplasia of the sacrum (HP:0008517)2.43612663
53Absent radius (HP:0003974)2.42910098
54True hermaphroditism (HP:0010459)2.42064208
55Pancreatic cysts (HP:0001737)2.38651591
56Increased CSF lactate (HP:0002490)2.38241549
57Acute necrotizing encephalopathy (HP:0006965)2.34557247
58Hepatic necrosis (HP:0002605)2.34412500
59Sloping forehead (HP:0000340)2.34019649
60Microretrognathia (HP:0000308)2.31867136
61Mitochondrial inheritance (HP:0001427)2.28557422
62Hypoplasia of the capital femoral epiphysis (HP:0003090)2.28294828
63Ependymoma (HP:0002888)2.27420804
64Nephroblastoma (Wilms tumor) (HP:0002667)2.27343453
65Pancytopenia (HP:0001876)2.26728701
66Type I transferrin isoform profile (HP:0003642)2.25522220
67Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.25305816
68Methylmalonic aciduria (HP:0012120)2.23007718
69Absent forearm bone (HP:0003953)2.22911571
70Aplasia involving forearm bones (HP:0009822)2.22911571
71Horseshoe kidney (HP:0000085)2.19559809
72Abnormality of methionine metabolism (HP:0010901)2.17469001
73Abnormal trabecular bone morphology (HP:0100671)2.17358798
74Abnormality of glycolysis (HP:0004366)2.17229843
75Increased serum pyruvate (HP:0003542)2.17229843
76Triphalangeal thumb (HP:0001199)2.15232232
77Abnormality of serum amino acid levels (HP:0003112)2.13818543
78Embryonal renal neoplasm (HP:0011794)2.13440634
79Lactic acidosis (HP:0003128)2.13283281
80Abnormality of midbrain morphology (HP:0002418)2.12771869
81Molar tooth sign on MRI (HP:0002419)2.12771869
82Abnormal mitochondria in muscle tissue (HP:0008316)2.12476868
83Volvulus (HP:0002580)2.12372195
84Neoplasm of the pancreas (HP:0002894)2.10786199
85Abnormality of the renal collecting system (HP:0004742)2.10681139
86Abnormal spermatogenesis (HP:0008669)2.10133274
87Cleft eyelid (HP:0000625)2.07790326
88Exertional dyspnea (HP:0002875)2.06886154
89Cellular immunodeficiency (HP:0005374)2.06289826
90Abnormality of the heme biosynthetic pathway (HP:0010472)2.04958696
91Increased intramyocellular lipid droplets (HP:0012240)2.04303852
92Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04003370
93Ectopic kidney (HP:0000086)2.03432743
94Duplicated collecting system (HP:0000081)2.03076752
95Abnormality of aspartate family amino acid metabolism (HP:0010899)2.01959262
96Abnormality of the duodenum (HP:0002246)2.01780388
97Thrombocytosis (HP:0001894)2.00328322
983-Methylglutaconic aciduria (HP:0003535)2.00155125
99Increased hepatocellular lipid droplets (HP:0006565)1.98267726
100Irregular epiphyses (HP:0010582)1.98087431
101Stenosis of the external auditory canal (HP:0000402)1.97762899
102Poor head control (HP:0002421)1.97719436
103Rhabdomyosarcoma (HP:0002859)1.97364486
104Secondary amenorrhea (HP:0000869)1.95234530
105Leukodystrophy (HP:0002415)1.94527846
106Abnormal number of incisors (HP:0011064)1.93707846
107Intestinal atresia (HP:0011100)1.93707469
108Absent septum pellucidum (HP:0001331)1.92656816
109Optic disc pallor (HP:0000543)1.91014074
110Asplenia (HP:0001746)1.90660210
111Congenital, generalized hypertrichosis (HP:0004540)1.89369507
112Sclerocornea (HP:0000647)1.88614281
113Tracheoesophageal fistula (HP:0002575)1.88052144
114Nephronophthisis (HP:0000090)1.87897655
115Respiratory difficulties (HP:0002880)1.87394410
116Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.86845408
117Atresia of the external auditory canal (HP:0000413)1.86676247
118Anencephaly (HP:0002323)1.85240763
119Abnormality of glycine metabolism (HP:0010895)1.84687823
120Abnormality of serine family amino acid metabolism (HP:0010894)1.84687823
121Neoplasm of the colon (HP:0100273)1.84005754
122Hypoplasia of the radius (HP:0002984)1.83765637
123Type 2 muscle fiber atrophy (HP:0003554)1.83509449
124Abnormality of the carotid arteries (HP:0005344)1.83482105
125Premature ovarian failure (HP:0008209)1.82822068
126Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.82758644
127Absent epiphyses (HP:0010577)1.82758644
128Exercise intolerance (HP:0003546)1.82572085
129Respiratory failure (HP:0002878)1.82523604
130Hypoplastic pelvis (HP:0008839)1.82030967
131Multiple enchondromatosis (HP:0005701)1.81999330
132Bifid tongue (HP:0010297)1.80921874
133Clubbing of toes (HP:0100760)1.79652873
134Facial cleft (HP:0002006)1.79555834
135Pendular nystagmus (HP:0012043)1.78781799
136Anophthalmia (HP:0000528)1.78778853
137Aplasia/Hypoplasia of the tongue (HP:0010295)1.78069971
138Optic nerve coloboma (HP:0000588)1.78007363
139Lipid accumulation in hepatocytes (HP:0006561)1.76526116
140Hyperglycinuria (HP:0003108)1.75738933
141Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74248061
142Abnormal protein N-linked glycosylation (HP:0012347)1.74248061
143Abnormal protein glycosylation (HP:0012346)1.74248061
144Abnormal glycosylation (HP:0012345)1.74248061
145Preaxial hand polydactyly (HP:0001177)1.73854262
146Abnormality of the septum pellucidum (HP:0007375)1.73843883
147Lethargy (HP:0001254)1.73820675

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.91614839
2WEE14.24028420
3EIF2AK14.23453189
4CDC74.14746642
5VRK23.89862563
6SRPK12.84186154
7STK162.77840842
8PLK42.63928161
9BRSK22.53393211
10EIF2AK32.33593892
11NEK22.28034480
12VRK12.27703807
13NEK12.25751668
14TTK2.14473384
15WNK32.13243191
16TAF12.11228628
17NME22.10942546
18PLK12.01337919
19TRIM282.00099701
20TSSK61.99488149
21MKNK11.95532861
22ACVR1B1.90889344
23BMPR1B1.87914921
24ATR1.81357238
25CCNB11.75692718
26AURKB1.65976487
27PLK31.63486410
28PDK41.57821421
29PDK31.57821421
30MAP4K21.56826399
31CDK71.56746127
32BRSK11.55162519
33PASK1.51885623
34TNIK1.48678845
35TESK21.40573513
36ZAK1.39759754
37PBK1.38088397
38TLK11.33558342
39MKNK21.30790551
40AURKA1.30338628
41CHEK21.29421221
42RPS6KB21.25391690
43CDK81.19891173
44BCR1.16785931
45TESK11.14505350
46PLK21.11311894
47EIF2AK21.09058526
48CHEK11.05876997
49RPS6KA41.04690011
50PIM21.03263372
51MAP3K81.02481339
52DYRK31.02453211
53STK41.00075880
54TGFBR10.97998309
55BRAF0.96800160
56GRK10.93203175
57PAK40.91875645
58CSNK1G10.89604501
59CDK40.88680610
60STK38L0.88068650
61CSNK1G30.83447943
62CSNK2A10.81919913
63ATM0.81907095
64PDK20.80000384
65EPHA20.77257172
66ADRBK20.77172229
67ERBB30.76967104
68CDK190.76777030
69CSNK1G20.76455193
70STK100.74857391
71PIM10.73317518
72CSNK2A20.73093490
73FRK0.71888652
74MAP3K40.70427826
75INSRR0.68508880
76MST40.67220953
77CDK20.66773274
78PAK10.62129934
79KDR0.62111244
80NME10.61261318
81FLT30.60999608
82MELK0.59276514
83OXSR10.57944526
84TEC0.57322531
85CSNK1A1L0.57110028
86CLK10.52609162
87CDK10.52552277
88SCYL20.50821543
89MAPK130.50085151
90MAP3K110.48453454
91MAP3K120.48388294
92TIE10.48315857
93PNCK0.47656262
94RPS6KA50.46484596
95ILK0.43887225
96STK390.42175153
97BCKDK0.41939511
98OBSCN0.41557489
99MAP4K10.41475458
100IRAK40.39280833
101NEK90.39122783
102CDK30.39033413
103MAP2K70.38721967
104CSNK1E0.36634037
105PRKCG0.35624884
106BTK0.34854513
107STK240.34374874
108ALK0.34345014
109YES10.33964160
110DYRK20.32828704
111MYLK0.32244744
112MINK10.32043986
113FGFR10.31195594
114MAPKAPK50.31038483
115STK30.30835006
116LIMK10.30782813
117ABL20.30345520
118LRRK20.29508000
119RPS6KA60.28166127
120PRKCI0.28114188
121TAOK20.28023768
122ERBB40.27878020
123RPS6KB10.27054993
124AKT30.26987006
125CSNK1A10.26180116
126ARAF0.25941269
127PINK10.25570270
128RPS6KC10.25568307
129RPS6KL10.25568307
130MAP2K30.25409160
131TXK0.24633161
132WNK40.21998858
133PRKDC0.21603340
134MAP2K60.21357720
135CASK0.21138098
136CDK180.21136492
137NUAK10.20796707
138DAPK10.20103328
139CDK60.19825957
140CDK140.19021669

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.14843512
2Mismatch repair_Homo sapiens_hsa034304.52579334
3Proteasome_Homo sapiens_hsa030503.96848990
4Ribosome_Homo sapiens_hsa030103.67446984
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.44394308
6RNA polymerase_Homo sapiens_hsa030203.40238650
7Homologous recombination_Homo sapiens_hsa034403.24284846
8Spliceosome_Homo sapiens_hsa030403.06401729
9Base excision repair_Homo sapiens_hsa034103.01648913
10RNA transport_Homo sapiens_hsa030132.88055772
11Nucleotide excision repair_Homo sapiens_hsa034202.87028608
12Pyrimidine metabolism_Homo sapiens_hsa002402.67766553
13Cell cycle_Homo sapiens_hsa041102.58369209
14Fanconi anemia pathway_Homo sapiens_hsa034602.32823430
15One carbon pool by folate_Homo sapiens_hsa006702.24916595
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.23167397
17Non-homologous end-joining_Homo sapiens_hsa034502.21725266
18Basal transcription factors_Homo sapiens_hsa030222.07881596
19RNA degradation_Homo sapiens_hsa030181.93835618
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76761456
21Purine metabolism_Homo sapiens_hsa002301.58549497
22mRNA surveillance pathway_Homo sapiens_hsa030151.41168320
23p53 signaling pathway_Homo sapiens_hsa041151.33263046
24Parkinsons disease_Homo sapiens_hsa050121.28538239
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28395588
26Protein export_Homo sapiens_hsa030601.28068014
27Huntingtons disease_Homo sapiens_hsa050161.27840570
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24794473
29Fatty acid elongation_Homo sapiens_hsa000621.15427770
30Oxidative phosphorylation_Homo sapiens_hsa001901.08945708
31Epstein-Barr virus infection_Homo sapiens_hsa051691.08332350
32Steroid biosynthesis_Homo sapiens_hsa001001.04881483
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02389300
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01961087
35Pentose phosphate pathway_Homo sapiens_hsa000300.98204952
36Cysteine and methionine metabolism_Homo sapiens_hsa002700.94458076
37Oocyte meiosis_Homo sapiens_hsa041140.91609090
38Systemic lupus erythematosus_Homo sapiens_hsa053220.90717783
39Butanoate metabolism_Homo sapiens_hsa006500.88232268
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84954719
41Folate biosynthesis_Homo sapiens_hsa007900.83257822
42Biosynthesis of amino acids_Homo sapiens_hsa012300.81467530
43Glutathione metabolism_Homo sapiens_hsa004800.79683646
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76522421
45Vitamin B6 metabolism_Homo sapiens_hsa007500.76417667
46Herpes simplex infection_Homo sapiens_hsa051680.76247123
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.72975804
48Carbon metabolism_Homo sapiens_hsa012000.71848700
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71799479
50Phototransduction_Homo sapiens_hsa047440.70148163
51Antigen processing and presentation_Homo sapiens_hsa046120.68040447
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64480267
53Peroxisome_Homo sapiens_hsa041460.64303556
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63079664
55Viral carcinogenesis_Homo sapiens_hsa052030.61438169
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61419170
57Fructose and mannose metabolism_Homo sapiens_hsa000510.56149892
58Selenocompound metabolism_Homo sapiens_hsa004500.55402922
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52728522
60Tryptophan metabolism_Homo sapiens_hsa003800.52503652
61Alzheimers disease_Homo sapiens_hsa050100.51301252
62HTLV-I infection_Homo sapiens_hsa051660.49471354
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49265923
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49261802
65N-Glycan biosynthesis_Homo sapiens_hsa005100.47712429
66Pyruvate metabolism_Homo sapiens_hsa006200.47065658
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46933852
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46689245
69Sulfur relay system_Homo sapiens_hsa041220.46678269
70Arachidonic acid metabolism_Homo sapiens_hsa005900.46677115
71Legionellosis_Homo sapiens_hsa051340.45617539
72Fatty acid metabolism_Homo sapiens_hsa012120.45394734
73Metabolic pathways_Homo sapiens_hsa011000.45094919
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44297335
75Caffeine metabolism_Homo sapiens_hsa002320.44199504
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.43133768
77Nitrogen metabolism_Homo sapiens_hsa009100.39801752
78Fatty acid degradation_Homo sapiens_hsa000710.39492917
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39145029
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37310832
81Galactose metabolism_Homo sapiens_hsa000520.37275782
82Thyroid cancer_Homo sapiens_hsa052160.36289145
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35069527
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30396613
85Sulfur metabolism_Homo sapiens_hsa009200.30215182
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29238970
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.28965829
88Primary immunodeficiency_Homo sapiens_hsa053400.28437726
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27150534
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25780495
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25418644
92Retinol metabolism_Homo sapiens_hsa008300.24360893
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23571693
94Vitamin digestion and absorption_Homo sapiens_hsa049770.22911962
95Chemical carcinogenesis_Homo sapiens_hsa052040.22680475
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22567714
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20611439
98Wnt signaling pathway_Homo sapiens_hsa043100.20210696
99Measles_Homo sapiens_hsa051620.19634703
100Ether lipid metabolism_Homo sapiens_hsa005650.18524366
101MicroRNAs in cancer_Homo sapiens_hsa052060.17631676
102Alcoholism_Homo sapiens_hsa050340.17501223
103Olfactory transduction_Homo sapiens_hsa047400.17236372
104Small cell lung cancer_Homo sapiens_hsa052220.17164590
105Apoptosis_Homo sapiens_hsa042100.16921784
106beta-Alanine metabolism_Homo sapiens_hsa004100.16413611
107TGF-beta signaling pathway_Homo sapiens_hsa043500.16186328
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16009385
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.15825935
110Linoleic acid metabolism_Homo sapiens_hsa005910.15680462
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15640202
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.14575393
113Nicotine addiction_Homo sapiens_hsa050330.13676627
114Cardiac muscle contraction_Homo sapiens_hsa042600.13500968
115Basal cell carcinoma_Homo sapiens_hsa052170.13295460
116Shigellosis_Homo sapiens_hsa051310.13037224
117Hepatitis B_Homo sapiens_hsa051610.11597224
118Propanoate metabolism_Homo sapiens_hsa006400.10080557
119HIF-1 signaling pathway_Homo sapiens_hsa040660.09822353
120Hippo signaling pathway_Homo sapiens_hsa043900.08059177
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.07837079
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.07690114
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.07560032
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.07558991
125Influenza A_Homo sapiens_hsa051640.07513757
126Arginine and proline metabolism_Homo sapiens_hsa003300.06126236
127Hematopoietic cell lineage_Homo sapiens_hsa046400.05360007
128Hedgehog signaling pathway_Homo sapiens_hsa043400.04280655
129Colorectal cancer_Homo sapiens_hsa052100.03361349
130Pathways in cancer_Homo sapiens_hsa052000.02831201
131Regulation of autophagy_Homo sapiens_hsa041400.01888067
132Intestinal immune network for IgA production_Homo sapiens_hsa046720.01408162

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