HAUS1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)6.10331677
2positive regulation of actin cytoskeleton reorganization (GO:2000251)5.96272087
3cytidine metabolic process (GO:0046087)5.67893956
4cytidine catabolic process (GO:0006216)5.67893956
5cytidine deamination (GO:0009972)5.67893956
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.19582139
7enteric nervous system development (GO:0048484)5.07573830
8DNA deamination (GO:0045006)5.04811740
9pyrimidine ribonucleoside catabolic process (GO:0046133)4.95187549
10lateral ventricle development (GO:0021670)4.85596755
11epithelial cilium movement (GO:0003351)4.80973136
12axonemal dynein complex assembly (GO:0070286)4.71628581
13artery smooth muscle contraction (GO:0014824)4.68863920
14positive regulation of gamma-delta T cell activation (GO:0046645)4.51036826
15detection of temperature stimulus involved in sensory perception (GO:0050961)4.41082771
16detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.41082771
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.29757730
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.25268412
19platelet dense granule organization (GO:0060155)4.24636243
20left/right pattern formation (GO:0060972)4.20684986
21detection of temperature stimulus (GO:0016048)4.19214913
22cilium or flagellum-dependent cell motility (GO:0001539)4.15008078
23induction of positive chemotaxis (GO:0050930)4.14881657
24positive regulation of interleukin-8 secretion (GO:2000484)4.10148960
25regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.08518882
26urinary tract smooth muscle contraction (GO:0014848)4.04769670
27sleep (GO:0030431)4.00406098
28tonic smooth muscle contraction (GO:0014820)3.89340765
29mannosylation (GO:0097502)3.88449856
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.63927610
31negative regulation of cell killing (GO:0031342)3.63927610
32positive T cell selection (GO:0043368)3.61227688
33purine nucleotide salvage (GO:0032261)3.59425172
34fucosylation (GO:0036065)3.52971352
35negative regulation by host of viral transcription (GO:0043922)3.49231897
36RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.43477833
37tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.43477833
38positive thymic T cell selection (GO:0045059)3.41982575
39detection of molecule of bacterial origin (GO:0032490)3.41476473
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.41038758
41modulation by symbiont of host immune response (GO:0052553)3.41038758
42positive regulation by symbiont of host defense response (GO:0052509)3.41038758
43modulation by symbiont of host defense response (GO:0052031)3.41038758
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.41038758
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.41038758
46response to interleukin-15 (GO:0070672)3.40048487
47synaptic transmission, dopaminergic (GO:0001963)3.37394168
48regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.34179598
49cellular response to interleukin-15 (GO:0071350)3.32264894
50regulation of B cell receptor signaling pathway (GO:0050855)3.30037567
51positive regulation of TOR signaling (GO:0032008)3.29936709
52negative regulation of granulocyte differentiation (GO:0030853)3.29454989
53cilium movement (GO:0003341)3.24449337
54response to xenobiotic stimulus (GO:0009410)3.24324678
55cellular ketone body metabolic process (GO:0046950)3.22302773
56negative regulation of T-helper cell differentiation (GO:0045623)3.21795192
57negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.21795192
58regulation of regulatory T cell differentiation (GO:0045589)3.15230861
59negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.15066088
60serotonin receptor signaling pathway (GO:0007210)3.13741160
61negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.12625781
62microglial cell activation (GO:0001774)3.04634332
63mechanoreceptor differentiation (GO:0042490)3.02199682
64positive regulation of natural killer cell mediated immunity (GO:0002717)3.01563633
65positive regulation of receptor internalization (GO:0002092)2.98080861
66cellular extravasation (GO:0045123)2.96680189
67regulation of natural killer cell mediated immunity (GO:0002715)2.95730593
68regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.95730593
69regulation of interleukin-12 biosynthetic process (GO:0045075)2.93153934
70regulation of phospholipid biosynthetic process (GO:0071071)2.91334820
71lymphocyte chemotaxis (GO:0048247)2.89338850
72cellular response to gamma radiation (GO:0071480)2.89230783
73response to host (GO:0075136)2.88984612
74response to host defenses (GO:0052200)2.88984612
75response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.88984612
76intraciliary transport (GO:0042073)2.88856843
77macrophage activation involved in immune response (GO:0002281)2.88140611
78positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.87407167
79positive regulation of interleukin-1 beta secretion (GO:0050718)2.86810365
80regulation of gamma-delta T cell differentiation (GO:0045586)2.85643380
81ketone body metabolic process (GO:1902224)2.85490729
82regulation of interleukin-8 secretion (GO:2000482)2.83564707
83regulation of gamma-delta T cell activation (GO:0046643)2.83085157
84regulation of receptor internalization (GO:0002090)2.80654566
85T cell migration (GO:0072678)2.75964455
86negative regulation of interleukin-12 production (GO:0032695)2.75108003
87macrophage chemotaxis (GO:0048246)2.70952255
88vascular smooth muscle contraction (GO:0014829)2.70433141
89positive regulation of interleukin-1 secretion (GO:0050716)2.68914366
90negative T cell selection (GO:0043383)2.68644410
91regulation of interleukin-1 beta secretion (GO:0050706)2.64566922
92positive regulation of interleukin-1 beta production (GO:0032731)2.64264571
93response to host immune response (GO:0052572)2.63362780
94response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.63362780
95detection of external biotic stimulus (GO:0098581)2.63021697
96positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.61891195
97positive regulation of interleukin-1 production (GO:0032732)2.60776577
98granulocyte activation (GO:0036230)2.58889341
99cytolysis (GO:0019835)2.58663113
100dendritic cell migration (GO:0036336)2.58137114

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.35019454
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.94147855
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.20504789
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.44154257
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.34117623
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.28969197
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.92620604
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.71104587
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.60931865
10TAF15_26573619_Chip-Seq_HEK293_Human2.50563343
11RUNX_20019798_ChIP-Seq_JUKART_Human2.31342756
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.26166559
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18901828
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.10065931
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04663670
16LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.00760516
17SPI1_23547873_ChIP-Seq_NB4_Human1.98867156
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.94689616
19FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.89315791
20ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85297563
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77357015
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.76631489
23EZH2_22144423_ChIP-Seq_EOC_Human1.72615796
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66869131
25TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.64632510
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64453275
27GATA3_27048872_Chip-Seq_THYMUS_Human1.63761933
28IRF1_19129219_ChIP-ChIP_H3396_Human1.61752465
29PRDM14_20953172_ChIP-Seq_ESCs_Human1.61374959
30SCL_19346495_ChIP-Seq_HPC-7_Human1.58311812
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.57839598
32VDR_23849224_ChIP-Seq_CD4+_Human1.57605926
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.57238603
34MYB_26560356_Chip-Seq_TH2_Human1.56323172
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55663693
36PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49094471
37EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.49014656
38GATA3_26560356_Chip-Seq_TH2_Human1.44415509
39SPI1_23127762_ChIP-Seq_K562_Human1.42057287
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.41953099
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.40615593
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.38908444
43ER_23166858_ChIP-Seq_MCF-7_Human1.36356292
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.31444150
45BCAT_22108803_ChIP-Seq_LS180_Human1.31173268
46GATA1_22025678_ChIP-Seq_K562_Human1.30537106
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29760773
48STAT1_20625510_ChIP-Seq_HELA_Human1.29520559
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29173665
50NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.29075673
51P300_19829295_ChIP-Seq_ESCs_Human1.27736774
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26977306
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26163209
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24684469
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.24656636
56CEBPB_22108803_ChIP-Seq_LS180_Human1.23853101
57SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23476216
58GBX2_23144817_ChIP-Seq_PC3_Human1.22145056
59EST1_17652178_ChIP-ChIP_JURKAT_Human1.18392088
60TCF4_18268006_ChIP-ChIP_LS174T_Human1.17529174
61FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16873811
62EWS_26573619_Chip-Seq_HEK293_Human1.13017429
63CBP_20019798_ChIP-Seq_JUKART_Human1.12443048
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12443048
65PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10378652
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10123381
67TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.09822745
68P300_18555785_Chip-Seq_ESCs_Mouse1.07960218
69CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05317489
70LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04288874
71RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.02118087
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01640037
73ELK1_19687146_ChIP-ChIP_HELA_Human1.01013743
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98560496
75SMAD3_21741376_ChIP-Seq_HESCs_Human0.95455587
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95294335
77CBP_21632823_ChIP-Seq_H3396_Human0.94164591
78EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94090426
79SOX2_19829295_ChIP-Seq_ESCs_Human0.93807684
80NANOG_19829295_ChIP-Seq_ESCs_Human0.93807684
81UTX_26944678_Chip-Seq_JUKART_Human0.89347582
82PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88555037
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87962129
84SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.87129100
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86693736
86CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86441512
87VDR_24787735_ChIP-Seq_THP-1_Human0.86216839
88NANOG_18555785_Chip-Seq_ESCs_Mouse0.85860814
89AR_20517297_ChIP-Seq_VCAP_Human0.85697713
90FOXH1_21741376_ChIP-Seq_EPCs_Human0.85619129
91GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.85317527
92RUNX1_27457419_Chip-Seq_LIVER_Mouse0.84713425
93CMYC_18555785_Chip-Seq_ESCs_Mouse0.84626103
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84618994
95NFYA_21822215_ChIP-Seq_K562_Human0.82219117
96P53_22387025_ChIP-Seq_ESCs_Mouse0.81184790
97ELK1_22589737_ChIP-Seq_MCF10A_Human0.81074318
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81003396
99KDM2B_26808549_Chip-Seq_REH_Human0.80566812
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.80227278

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003828_pulmonary_edema4.75523991
2MP0009379_abnormal_foot_pigmentation4.29271074
3MP0003724_increased_susceptibility_to4.06436167
4MP0005671_abnormal_response_to3.55325796
5MP0002295_abnormal_pulmonary_circulatio3.09972026
6MP0009785_altered_susceptibility_to2.93178217
7MP0001835_abnormal_antigen_presentation2.77286761
8MP0010030_abnormal_orbit_morphology2.47827134
9MP0002148_abnormal_hypersensitivity_rea2.37499896
10MP0005025_abnormal_response_to2.13599948
11MP0001800_abnormal_humoral_immune2.13492402
12MP0002166_altered_tumor_susceptibility2.12025975
13MP0000685_abnormal_immune_system2.03220216
14MP0006082_CNS_inflammation1.92609549
15MP0002138_abnormal_hepatobiliary_system1.91744009
16MP0002723_abnormal_immune_serum1.89912914
17MP0003806_abnormal_nucleotide_metabolis1.88307001
18MP0005000_abnormal_immune_tolerance1.87430783
19MP0005084_abnormal_gallbladder_morpholo1.86946798
20MP0001188_hyperpigmentation1.83374224
21MP0002127_abnormal_cardiovascular_syste1.81737823
22MP0002419_abnormal_innate_immunity1.79973598
23MP0002420_abnormal_adaptive_immunity1.76314156
24MP0003866_abnormal_defecation1.75107517
25MP0003787_abnormal_imprinting1.74885745
26MP0001819_abnormal_immune_cell1.73259745
27MP0010155_abnormal_intestine_physiology1.71743366
28MP0002452_abnormal_antigen_presenting1.71487229
29MP0003252_abnormal_bile_duct1.68072701
30MP0002396_abnormal_hematopoietic_system1.67798430
31MP0004883_abnormal_blood_vessel1.57951233
32MP0001984_abnormal_olfaction1.57718282
33MP0006276_abnormal_autonomic_nervous1.54923614
34MP0000579_abnormal_nail_morphology1.54675904
35MP0002006_tumorigenesis1.50795686
36MP0001790_abnormal_immune_system1.49957007
37MP0005387_immune_system_phenotype1.49957007
38MP0009764_decreased_sensitivity_to1.48717796
39MP0003436_decreased_susceptibility_to1.45900394
40MP0002090_abnormal_vision1.43923123
41MP0002108_abnormal_muscle_morphology1.43813227
42MP0001270_distended_abdomen1.39697558
43MP0008877_abnormal_DNA_methylation1.38903039
44MP0000858_altered_metastatic_potential1.37715105
45MP0005197_abnormal_uvea_morphology1.37128561
46MP0000372_irregular_coat_pigmentation1.36920021
47MP0005377_hearing/vestibular/ear_phenot1.35718805
48MP0003878_abnormal_ear_physiology1.35718805
49MP0005464_abnormal_platelet_physiology1.33936930
50MP0005174_abnormal_tail_pigmentation1.32672583
51MP0000716_abnormal_immune_system1.30421500
52MP0002405_respiratory_system_inflammati1.30090500
53MP0002398_abnormal_bone_marrow1.29872593
54MP0000490_abnormal_crypts_of1.26857855
55MP0000767_abnormal_smooth_muscle1.25282201
56MP0001845_abnormal_inflammatory_respons1.23711774
57MP0005503_abnormal_tendon_morphology1.21915198
58MP0002933_joint_inflammation1.17997089
59MP0002751_abnormal_autonomic_nervous1.17553990
60MP0002653_abnormal_ependyma_morphology1.12722939
61MP0005075_abnormal_melanosome_morpholog1.10995552
62MP0002102_abnormal_ear_morphology1.10693370
63MP0003763_abnormal_thymus_physiology1.07321641
64MP0003448_altered_tumor_morphology1.06945800
65MP0001533_abnormal_skeleton_physiology1.06068740
66MP0000689_abnormal_spleen_morphology1.06033115
67MP0002722_abnormal_immune_system1.05096685
68MP0008469_abnormal_protein_level1.03615127
69MP0001764_abnormal_homeostasis1.03297979
70MP0004264_abnormal_extraembryonic_tissu1.02240107
71MP0006054_spinal_hemorrhage1.01856741
72MP0002429_abnormal_blood_cell1.00684246
73MP0005423_abnormal_somatic_nervous0.99231758
74MP0002277_abnormal_respiratory_mucosa0.98086676
75MP0002132_abnormal_respiratory_system0.96508444
76MP0002009_preneoplasia0.94563405
77MP0000015_abnormal_ear_pigmentation0.94376770
78MP0001324_abnormal_eye_pigmentation0.94098017
79MP0000703_abnormal_thymus_morphology0.92546367
80MP0004484_altered_response_of0.92097710
81MP0002233_abnormal_nose_morphology0.88782724
82MP0001348_abnormal_lacrimal_gland0.87258586
83MP0005085_abnormal_gallbladder_physiolo0.86477170
84MP0000343_altered_response_to0.85725485
85MP0005388_respiratory_system_phenotype0.85456181
86MP0002133_abnormal_respiratory_system0.85456181
87MP0002095_abnormal_skin_pigmentation0.82198052
88MP0002184_abnormal_innervation0.80879976
89MP0002234_abnormal_pharynx_morphology0.80618405
90MP0003186_abnormal_redox_activity0.79939557
91MP0006072_abnormal_retinal_apoptosis0.79058340
92MP0005166_decreased_susceptibility_to0.76752494
93MP0005376_homeostasis/metabolism_phenot0.74346369
94MP0002928_abnormal_bile_duct0.72529282
95MP0005390_skeleton_phenotype0.71915880
96MP0008995_early_reproductive_senescence0.71903563
97MP0010368_abnormal_lymphatic_system0.71898925
98MP0006035_abnormal_mitochondrial_morpho0.69913274
99MP0005164_abnormal_response_to0.66661294
100MP0002269_muscular_atrophy0.65462578

Predicted human phenotypes

RankGene SetZ-score
1Polyphagia (HP:0002591)6.20421047
2Abnormal drinking behavior (HP:0030082)4.73339768
3Polydipsia (HP:0001959)4.73339768
4Chronic sinusitis (HP:0011109)4.27617451
5Abnormal delayed hypersensitivity skin test (HP:0002963)3.96300302
6Panhypogammaglobulinemia (HP:0003139)3.91005441
7Muscle fiber splitting (HP:0003555)3.87572345
8Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.49798154
9Recurrent cutaneous fungal infections (HP:0011370)3.45924133
10Chronic mucocutaneous candidiasis (HP:0002728)3.45924133
11Recurrent bacterial skin infections (HP:0005406)3.41634225
12Abnormal respiratory motile cilium morphology (HP:0005938)3.40826115
13Abnormal respiratory epithelium morphology (HP:0012253)3.40826115
14Abnormal eating behavior (HP:0100738)3.36128631
15Glycosuria (HP:0003076)3.31712023
16Abnormality of urine glucose concentration (HP:0011016)3.31712023
17Abnormal biliary tract physiology (HP:0012439)3.28989688
18Bile duct proliferation (HP:0001408)3.28989688
19Recurrent gram-negative bacterial infections (HP:0005420)3.27200996
20Concave nail (HP:0001598)3.26714607
21Polyuria (HP:0000103)3.21738967
22Encephalitis (HP:0002383)3.13627894
23IgM deficiency (HP:0002850)3.12654345
24Thoracolumbar scoliosis (HP:0002944)3.11627292
25Bifid tongue (HP:0010297)3.11156141
26Agammaglobulinemia (HP:0004432)3.06457376
27Recurrent abscess formation (HP:0002722)3.02595942
28Abnormal ciliary motility (HP:0012262)2.94725723
29Abnormality of the labia minora (HP:0012880)2.91790788
30Abnormality of midbrain morphology (HP:0002418)2.86381609
31Molar tooth sign on MRI (HP:0002419)2.86381609
32Stomatitis (HP:0010280)2.72597965
33T lymphocytopenia (HP:0005403)2.72009901
34Neuroendocrine neoplasm (HP:0100634)2.71131646
35Recurrent fungal infections (HP:0002841)2.70090782
36Testicular atrophy (HP:0000029)2.65568826
37Recurrent skin infections (HP:0001581)2.64895138
38Elevated erythrocyte sedimentation rate (HP:0003565)2.64804766
39Short nail (HP:0001799)2.62832077
40Abnormal urine output (HP:0012590)2.61780676
41Mesomelia (HP:0003027)2.61659901
42Myositis (HP:0100614)2.60623732
43Meningitis (HP:0001287)2.58148547
44Recurrent bronchitis (HP:0002837)2.54968386
45Abnormal respiratory motile cilium physiology (HP:0012261)2.52699122
463-Methylglutaconic aciduria (HP:0003535)2.52612406
47Abnormality of T cell number (HP:0011839)2.46609905
48Optic neuritis (HP:0100653)2.46606840
49Retrobulbar optic neuritis (HP:0100654)2.46606840
50Abnormality of T cells (HP:0002843)2.46121560
51Chronic otitis media (HP:0000389)2.41881527
52Microvesicular hepatic steatosis (HP:0001414)2.41578641
53Abnormality of glycolipid metabolism (HP:0010969)2.40011642
54Abnormality of liposaccharide metabolism (HP:0010968)2.40011642
55Abnormality of glycosphingolipid metabolism (HP:0004343)2.40011642
56Short middle phalanx of the 5th finger (HP:0004220)2.39528654
57Abnormality of oral frenula (HP:0000190)2.37371796
58Recurrent viral infections (HP:0004429)2.36337255
59Orchitis (HP:0100796)2.32584910
60Tinnitus (HP:0000360)2.31654733
61Rhinitis (HP:0012384)2.31050765
62Gastrointestinal infarctions (HP:0005244)2.27528067
63Abnormality of renal excretion (HP:0011036)2.19992465
64Cone-rod dystrophy (HP:0000548)2.16890974
65Aplastic anemia (HP:0001915)2.15680379
66Absent phalangeal crease (HP:0006109)2.10833133
67Congenital, generalized hypertrichosis (HP:0004540)2.07948502
68Bronchiectasis (HP:0002110)2.07397581
69Abnormality of T cell physiology (HP:0011840)2.05319105
70Long foot (HP:0001833)2.00227519
71Pulmonary artery stenosis (HP:0004415)1.97681084
72Aplasia of the musculature (HP:0100854)1.97558384
73Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.94715150
74Anorexia (HP:0002039)1.94006143
75Severe combined immunodeficiency (HP:0004430)1.91823469
76Megaloblastic anemia (HP:0001889)1.87620856
77Type I transferrin isoform profile (HP:0003642)1.87450230
78Vasculitis (HP:0002633)1.86573304
79Partial duplication of the phalanx of hand (HP:0009999)1.85943756
80Hypoproteinemia (HP:0003075)1.85684941
81Keratoconjunctivitis sicca (HP:0001097)1.85101551
82Colitis (HP:0002583)1.85049940
83Acute hepatic failure (HP:0006554)1.84516358
84Eczematoid dermatitis (HP:0000976)1.82947101
85Recurrent corneal erosions (HP:0000495)1.82875208
86Inflammation of the large intestine (HP:0002037)1.81140322
87Acute necrotizing encephalopathy (HP:0006965)1.80160255
88Gangrene (HP:0100758)1.79275991
89Arterial thrombosis (HP:0004420)1.78109932
90Obstructive lung disease (HP:0006536)1.77314643
91Chronic obstructive pulmonary disease (HP:0006510)1.77314643
92Viral hepatitis (HP:0006562)1.76205946
93Rib fusion (HP:0000902)1.74578314
94Pheochromocytoma (HP:0002666)1.72129265
95Pulmonary embolism (HP:0002204)1.71434783
96Generalized hypopigmentation (HP:0007513)1.71236970
97Autoamputation (HP:0001218)1.70951855
98Abnormal gallbladder physiology (HP:0012438)1.69816299
99Cholecystitis (HP:0001082)1.69816299
100Hematochezia (HP:0002573)1.68540438

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK16.39382507
2TAOK33.84207638
3TXK3.09455288
4VRK22.22484563
5MAP3K112.18702906
6RIPK42.14885530
7KDR2.05651943
8IRAK42.04539717
9MAP3K122.03615700
10STK162.00749505
11BLK1.96501838
12MATK1.94942148
13MAP3K131.88020073
14ITK1.65438280
15MAP3K31.64616206
16BCKDK1.61723267
17PINK11.54362417
18FES1.48338322
19BTK1.44035588
20MAP3K61.42888493
21MAP4K21.39549660
22PNCK1.39111818
23PIK3CA1.38931270
24SMG11.38428003
25PIK3CG1.36532779
26MAP3K51.33954513
27MELK1.33337993
28KSR21.30905351
29CSK1.29513947
30WNK11.28560674
31BMPR21.27122731
32MAP4K11.26879511
33JAK31.25348033
34IKBKE1.22457050
35MAP3K141.20716343
36FGFR21.14649876
37GRK61.12726619
38MAP2K41.12235553
39ZAK1.08647150
40EIF2AK21.08533350
41MST41.07537332
42SYK1.04790319
43TYK21.04754579
44DYRK21.04701116
45MAP2K31.03422929
46MAP3K71.03325369
47CSNK1A1L1.02468086
48MOS1.01410551
49LCK0.99527728
50TEC0.99303455
51LRRK20.98852842
52ZAP700.96611785
53PKN10.91247274
54ADRBK20.91102527
55PRKCQ0.90745081
56GRK70.90497117
57LYN0.90088662
58TAF10.88301102
59JAK10.84649141
60CSNK1G20.84082287
61CDK80.83229148
62CDK90.79164859
63CSNK1G30.77863552
64IRAK20.74925979
65ADRBK10.74897942
66MAP3K10.74164298
67TBK10.74133598
68GRK10.73610157
69VRK10.71391529
70PASK0.71281234
71GRK50.70219599
72RAF10.69739179
73HCK0.69669407
74RET0.60911375
75ARAF0.58421780
76TNK20.58212072
77PTK2B0.57970799
78FGR0.57558951
79DYRK1B0.56634529
80MAP2K60.54342169
81IKBKB0.52738657
82KIT0.50688587
83BUB10.49839051
84NUAK10.49367228
85CSF1R0.46655245
86SIK30.45800208
87TESK20.43380368
88IRAK10.43140911
89MAP3K20.42394204
90DYRK1A0.42268251
91FRK0.39666165
92IGF1R0.38230566
93NTRK10.37343611
94CLK10.36988808
95MAPKAPK20.36842700
96MARK30.36773356
97SRPK10.33311046
98MAP3K40.32446995
99DAPK30.31562406
100STK110.30802983

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.46633882
2Proteasome_Homo sapiens_hsa030503.20347426
3Ribosome_Homo sapiens_hsa030102.90344267
4Graft-versus-host disease_Homo sapiens_hsa053322.73830884
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.66950999
6Oxidative phosphorylation_Homo sapiens_hsa001902.50250761
7Antigen processing and presentation_Homo sapiens_hsa046122.45385165
8Allograft rejection_Homo sapiens_hsa053302.43928241
9Autoimmune thyroid disease_Homo sapiens_hsa053202.36820003
10Leishmaniasis_Homo sapiens_hsa051402.27861828
11Hematopoietic cell lineage_Homo sapiens_hsa046402.25330974
12Parkinsons disease_Homo sapiens_hsa050122.19840700
13Staphylococcus aureus infection_Homo sapiens_hsa051501.93279486
14Malaria_Homo sapiens_hsa051441.92295221
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.92128917
16Rheumatoid arthritis_Homo sapiens_hsa053231.86030100
17Type I diabetes mellitus_Homo sapiens_hsa049401.83568115
18Thyroid cancer_Homo sapiens_hsa052161.83391684
19Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.83312922
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.83015424
21Protein export_Homo sapiens_hsa030601.76564600
22Alzheimers disease_Homo sapiens_hsa050101.74863143
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.65836591
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.65144258
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.62250572
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.60495299
27Huntingtons disease_Homo sapiens_hsa050161.59593222
28N-Glycan biosynthesis_Homo sapiens_hsa005101.52152614
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50986860
30Salmonella infection_Homo sapiens_hsa051321.45232215
31Tuberculosis_Homo sapiens_hsa051521.40288003
32T cell receptor signaling pathway_Homo sapiens_hsa046601.39286749
33Osteoclast differentiation_Homo sapiens_hsa043801.36945495
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30470906
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.23406819
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22094080
37Measles_Homo sapiens_hsa051621.16963652
38Chemokine signaling pathway_Homo sapiens_hsa040621.15308076
39Legionellosis_Homo sapiens_hsa051341.13678701
40Asthma_Homo sapiens_hsa053101.12822081
41Propanoate metabolism_Homo sapiens_hsa006401.03837418
42Neurotrophin signaling pathway_Homo sapiens_hsa047220.97593140
43NF-kappa B signaling pathway_Homo sapiens_hsa040640.97255431
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97251481
45Intestinal immune network for IgA production_Homo sapiens_hsa046720.94166707
46Arachidonic acid metabolism_Homo sapiens_hsa005900.83058613
47Butanoate metabolism_Homo sapiens_hsa006500.80643170
48Vitamin digestion and absorption_Homo sapiens_hsa049770.72085050
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71446473
50Cardiac muscle contraction_Homo sapiens_hsa042600.71207046
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66824220
52Viral myocarditis_Homo sapiens_hsa054160.66664586
53Phagosome_Homo sapiens_hsa041450.66542009
54Hepatitis B_Homo sapiens_hsa051610.64373784
55Herpes simplex infection_Homo sapiens_hsa051680.60509007
56Nucleotide excision repair_Homo sapiens_hsa034200.60271149
57RNA polymerase_Homo sapiens_hsa030200.59769347
58Basal cell carcinoma_Homo sapiens_hsa052170.59179545
59Serotonergic synapse_Homo sapiens_hsa047260.58489262
60TNF signaling pathway_Homo sapiens_hsa046680.57262567
61African trypanosomiasis_Homo sapiens_hsa051430.56522444
62RNA degradation_Homo sapiens_hsa030180.54686715
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.54537013
64Non-small cell lung cancer_Homo sapiens_hsa052230.53406326
65Caffeine metabolism_Homo sapiens_hsa002320.53213476
66Toxoplasmosis_Homo sapiens_hsa051450.52512250
67B cell receptor signaling pathway_Homo sapiens_hsa046620.51112990
68HTLV-I infection_Homo sapiens_hsa051660.49777684
69Renal cell carcinoma_Homo sapiens_hsa052110.48761592
70Apoptosis_Homo sapiens_hsa042100.46927562
71Influenza A_Homo sapiens_hsa051640.46217363
72Pancreatic cancer_Homo sapiens_hsa052120.45194242
73Notch signaling pathway_Homo sapiens_hsa043300.44523444
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44415683
75Glutathione metabolism_Homo sapiens_hsa004800.41498443
76Phototransduction_Homo sapiens_hsa047440.41474604
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.39670114
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38986955
79Nitrogen metabolism_Homo sapiens_hsa009100.37262709
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35932259
81Melanogenesis_Homo sapiens_hsa049160.35325781
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34534639
83Olfactory transduction_Homo sapiens_hsa047400.33408955
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33040834
85Systemic lupus erythematosus_Homo sapiens_hsa053220.32721829
86Pertussis_Homo sapiens_hsa051330.32429798
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.31523732
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31298674
89Hepatitis C_Homo sapiens_hsa051600.29678618
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29539749
91Long-term potentiation_Homo sapiens_hsa047200.28690363
92MAPK signaling pathway_Homo sapiens_hsa040100.28055516
93Peroxisome_Homo sapiens_hsa041460.27446328
94Epstein-Barr virus infection_Homo sapiens_hsa051690.26634285
95Amoebiasis_Homo sapiens_hsa051460.25365905
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24086506
97Cholinergic synapse_Homo sapiens_hsa047250.22131617
98Purine metabolism_Homo sapiens_hsa002300.20305586
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.19499019
100Chemical carcinogenesis_Homo sapiens_hsa052040.18696161

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