HAUS1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)7.64649021
2cytidine deamination (GO:0009972)7.33464414
3cytidine metabolic process (GO:0046087)7.33464414
4cytidine catabolic process (GO:0006216)7.33464414
5DNA deamination (GO:0045006)7.11263764
6pyrimidine ribonucleoside catabolic process (GO:0046133)6.28731408
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.25877730
8negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)5.68208740
9negative regulation by host of viral transcription (GO:0043922)4.66643987
10negative regulation of DNA-templated transcription, elongation (GO:0032785)4.62075383
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.55607265
12cellular ketone body metabolic process (GO:0046950)4.34064764
13platelet dense granule organization (GO:0060155)4.29772194
14positive T cell selection (GO:0043368)4.21459928
15positive regulation of interleukin-8 secretion (GO:2000484)4.20617612
16positive thymic T cell selection (GO:0045059)4.03467068
17DNA demethylation (GO:0080111)4.01035613
18establishment of protein localization to mitochondrial membrane (GO:0090151)3.95896189
19cytochrome complex assembly (GO:0017004)3.92096736
20respiratory chain complex IV assembly (GO:0008535)3.91320891
21ketone body metabolic process (GO:1902224)3.85797639
22positive regulation of defense response to virus by host (GO:0002230)3.85231596
23ATP synthesis coupled proton transport (GO:0015986)3.83070632
24energy coupled proton transport, down electrochemical gradient (GO:0015985)3.83070632
25protein-cofactor linkage (GO:0018065)3.81051168
26RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.70758769
27tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.70758769
28protein complex biogenesis (GO:0070271)3.69888194
29nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.63998691
30sequestering of actin monomers (GO:0042989)3.59944411
31eosinophil chemotaxis (GO:0048245)3.58497376
32exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.58048853
33respiratory electron transport chain (GO:0022904)3.55780707
34mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.55086141
35electron transport chain (GO:0022900)3.50829648
36positive regulation of T cell differentiation in thymus (GO:0033089)3.45446449
37mitochondrial respiratory chain complex assembly (GO:0033108)3.30010718
38DNA dealkylation (GO:0035510)3.28117628
39eosinophil migration (GO:0072677)3.24198028
40ribosomal small subunit assembly (GO:0000028)3.24146409
41signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.17845793
42signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.17845793
43signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.17845793
44DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.15937669
45iron-sulfur cluster assembly (GO:0016226)3.15724437
46metallo-sulfur cluster assembly (GO:0031163)3.15724437
47negative regulation of T cell apoptotic process (GO:0070233)3.15367105
48positive regulation of natural killer cell mediated immunity (GO:0002717)3.14193913
49protein neddylation (GO:0045116)3.11674234
50chaperone-mediated protein transport (GO:0072321)3.11552369
51cellular response to interleukin-15 (GO:0071350)3.10320348
52negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.06641813
53intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.05195175
54signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.05195175
55positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.04858607
56regulation of interleukin-8 secretion (GO:2000482)3.01943296
57signal transduction involved in DNA integrity checkpoint (GO:0072401)3.00004052
58signal transduction involved in DNA damage checkpoint (GO:0072422)3.00004052
59signal transduction involved in cell cycle checkpoint (GO:0072395)2.96606973
60rRNA catabolic process (GO:0016075)2.93031010
61regulation of cellular amino acid metabolic process (GO:0006521)2.92743469
62terpenoid biosynthetic process (GO:0016114)2.92590201
63regulation of activation of Janus kinase activity (GO:0010533)2.87874611
64proteasome assembly (GO:0043248)2.83790229
65purine nucleobase biosynthetic process (GO:0009113)2.82811684
66maturation of SSU-rRNA (GO:0030490)2.82142362
67pyrimidine nucleoside catabolic process (GO:0046135)2.78701797
68natural killer cell activation (GO:0030101)2.78142958
69negative regulation of thymocyte apoptotic process (GO:0070244)2.77450279
70mitochondrial DNA replication (GO:0006264)2.77387327
71positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.75950260
72regulation of memory T cell differentiation (GO:0043380)2.74699582
73negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.73862819
74negative regulation of ligase activity (GO:0051352)2.73862819
75kynurenine metabolic process (GO:0070189)2.72223814
76cytolysis (GO:0019835)2.71320981
77regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.70325065
78regulation of natural killer cell mediated immunity (GO:0002715)2.70325065
79postreplication repair (GO:0006301)2.69508738
80CENP-A containing nucleosome assembly (GO:0034080)2.69458607
81chromatin remodeling at centromere (GO:0031055)2.68085414
82regulation of meiosis I (GO:0060631)2.67260006
83positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.62903777
84maturation of 5.8S rRNA (GO:0000460)2.59907462
85modulation by host of symbiont transcription (GO:0052472)2.58423639
86modulation by host of viral transcription (GO:0043921)2.58423639
87regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.58187713
88S-adenosylmethionine metabolic process (GO:0046500)2.57999834
89regulation of leukocyte mediated cytotoxicity (GO:0001910)2.57965712
90regulation of cilium movement (GO:0003352)2.52712856
91mitochondrial respiratory chain complex I assembly (GO:0032981)2.50470654
92NADH dehydrogenase complex assembly (GO:0010257)2.50470654
93mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.50470654
94negative T cell selection (GO:0043383)2.49841611
95regulation of germinal center formation (GO:0002634)2.49511644
96antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.48813536
97nephron tubule morphogenesis (GO:0072078)2.47994818
98nephron epithelium morphogenesis (GO:0072088)2.47994818
99modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.47706316
100inner mitochondrial membrane organization (GO:0007007)2.47261370

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.31997034
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.11932117
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.98338556
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.62302979
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.54346665
6IGF1R_20145208_ChIP-Seq_DFB_Human3.12006624
7VDR_22108803_ChIP-Seq_LS180_Human3.03749936
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.95543622
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.85980691
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.84717274
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.83378044
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.72638660
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.58188086
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.47903161
15VDR_23849224_ChIP-Seq_CD4+_Human2.42942739
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.37615590
17ELK1_19687146_ChIP-ChIP_HELA_Human2.31647196
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.16285127
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13288679
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.07782784
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.02986444
22IRF8_21731497_ChIP-ChIP_J774_Mouse1.96488108
23IRF8_22096565_ChIP-ChIP_GC-B_Human1.90141138
24ZNF274_21170338_ChIP-Seq_K562_Hela1.87965794
25MYC_18940864_ChIP-ChIP_HL60_Human1.86501005
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.83844347
27FOXP3_21729870_ChIP-Seq_TREG_Human1.72426922
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65653565
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63478905
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.61361968
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60577065
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.58218246
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57816214
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48717059
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43334281
36TP53_22573176_ChIP-Seq_HFKS_Human1.39508519
37GATA3_26560356_Chip-Seq_TH2_Human1.34647331
38HTT_18923047_ChIP-ChIP_STHdh_Human1.34516951
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31180027
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.30887980
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30003593
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.29585896
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.28954010
44GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.28829953
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27165941
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26531531
47RBPJ_21746931_ChIP-Seq_IB4_Human1.25732206
48TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.23693685
49HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23614055
50EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22805897
51SOX2_19829295_ChIP-Seq_ESCs_Human1.22461052
52NANOG_19829295_ChIP-Seq_ESCs_Human1.22461052
53GATA3_27048872_Chip-Seq_THYMUS_Human1.22354511
54EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.21685589
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.19483662
56MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19455358
57GATA6_21074721_ChIP-Seq_CACO-2_Human1.19368896
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18864537
59FUS_26573619_Chip-Seq_HEK293_Human1.18712385
60FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18426797
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16804220
62MYB_26560356_Chip-Seq_TH2_Human1.16285515
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15294614
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.15294614
65P300_19829295_ChIP-Seq_ESCs_Human1.15283082
66PHF8_20622853_ChIP-Seq_HELA_Human1.14631919
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13493457
68AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13095013
69AR_20517297_ChIP-Seq_VCAP_Human1.12860516
70PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11543714
71MYC_18555785_ChIP-Seq_MESCs_Mouse1.11377141
72ETV1_20927104_ChIP-Seq_GIST48_Human1.10629677
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10234976
74RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09653901
75FOXH1_21741376_ChIP-Seq_EPCs_Human1.07822728
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07220662
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07088436
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06734189
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06147628
80CBP_20019798_ChIP-Seq_JUKART_Human1.06147628
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05413156
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05168739
83TAF2_19829295_ChIP-Seq_ESCs_Human1.04547137
84DCP1A_22483619_ChIP-Seq_HELA_Human1.03873132
85ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03620503
86NANOG_20526341_ChIP-Seq_ESCs_Human1.03508548
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03098385
88ER_23166858_ChIP-Seq_MCF-7_Human1.01117029
89NCOR_22424771_ChIP-Seq_293T_Human1.00429652
90EWS_26573619_Chip-Seq_HEK293_Human0.99588069
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98417228
92E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97970369
93MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97668710
94HNFA_21074721_ChIP-Seq_CACO-2_Human0.97612120
95CRX_20693478_ChIP-Seq_RETINA_Mouse0.97450645
96IRF1_19129219_ChIP-ChIP_H3396_Human0.95831647
97NFYB_21822215_ChIP-Seq_K562_Human0.94958468
98CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94294821
99GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.92510645
100CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.92191410

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.33581535
2MP0001188_hyperpigmentation4.07147788
3MP0005671_abnormal_response_to3.61356328
4MP0003011_delayed_dark_adaptation3.34289005
5MP0003786_premature_aging3.00330020
6MP0005377_hearing/vestibular/ear_phenot2.99183885
7MP0003878_abnormal_ear_physiology2.99183885
8MP0003195_calcinosis2.81018311
9MP0009785_altered_susceptibility_to2.72810451
10MP0002102_abnormal_ear_morphology2.42711790
11MP0002138_abnormal_hepatobiliary_system2.39789904
12MP0003763_abnormal_thymus_physiology2.22930146
13MP0000372_irregular_coat_pigmentation2.21395600
14MP0002234_abnormal_pharynx_morphology2.14343525
15MP0006082_CNS_inflammation2.01914607
16MP0008875_abnormal_xenobiotic_pharmacok2.00623959
17MP0005084_abnormal_gallbladder_morpholo1.97915137
18MP0004145_abnormal_muscle_electrophysio1.84137599
19MP0001835_abnormal_antigen_presentation1.82431101
20MP0002148_abnormal_hypersensitivity_rea1.82079165
21MP0002139_abnormal_hepatobiliary_system1.67907847
22MP0003283_abnormal_digestive_organ1.59026744
23MP0004043_abnormal_pH_regulation1.55599249
24MP0003567_abnormal_fetal_cardiomyocyte1.53312812
25MP0005645_abnormal_hypothalamus_physiol1.50746725
26MP0005075_abnormal_melanosome_morpholog1.49668621
27MP0001485_abnormal_pinna_reflex1.48037054
28MP0008872_abnormal_physiological_respon1.46088193
29MP0002876_abnormal_thyroid_physiology1.37001041
30MP0002166_altered_tumor_susceptibility1.34081926
31MP0005174_abnormal_tail_pigmentation1.33995052
32MP0005000_abnormal_immune_tolerance1.33991806
33MP0001800_abnormal_humoral_immune1.32132112
34MP0002736_abnormal_nociception_after1.29592800
35MP0001501_abnormal_sleep_pattern1.28111690
36MP0003724_increased_susceptibility_to1.25085498
37MP0001764_abnormal_homeostasis1.24248448
38MP0002723_abnormal_immune_serum1.23760582
39MP0002277_abnormal_respiratory_mucosa1.22292948
40MP0006036_abnormal_mitochondrial_physio1.20518263
41MP0001968_abnormal_touch/_nociception1.20279842
42MP0001984_abnormal_olfaction1.20143139
43MP0008877_abnormal_DNA_methylation1.18122887
44MP0008058_abnormal_DNA_repair1.18103680
45MP0002420_abnormal_adaptive_immunity1.17160622
46MP0004957_abnormal_blastocyst_morpholog1.16466890
47MP0001819_abnormal_immune_cell1.15419676
48MP0002006_tumorigenesis1.11733181
49MP0006276_abnormal_autonomic_nervous1.09683634
50MP0002837_dystrophic_cardiac_calcinosis1.09628459
51MP0006072_abnormal_retinal_apoptosis1.09037298
52MP0005025_abnormal_response_to1.08715737
53MP0003866_abnormal_defecation1.08447897
54MP0010155_abnormal_intestine_physiology1.07444746
55MP0009333_abnormal_splenocyte_physiolog1.05705008
56MP0004147_increased_porphyrin_level1.03093082
57MP0001661_extended_life_span1.02778203
58MP0003186_abnormal_redox_activity0.99529707
59MP0000689_abnormal_spleen_morphology0.99443845
60MP0008995_early_reproductive_senescence0.98868433
61MP0005551_abnormal_eye_electrophysiolog0.98511421
62MP0001529_abnormal_vocalization0.98447024
63MP0002638_abnormal_pupillary_reflex0.97995005
64MP0002398_abnormal_bone_marrow0.96488279
65MP0001919_abnormal_reproductive_system0.95424253
66MP0002722_abnormal_immune_system0.95416929
67MP0003693_abnormal_embryo_hatching0.93802562
68MP0000703_abnormal_thymus_morphology0.93120697
69MP0005167_abnormal_blood-brain_barrier0.92532281
70MP0003252_abnormal_bile_duct0.91100688
71MP0002452_abnormal_antigen_presenting0.90960922
72MP0002095_abnormal_skin_pigmentation0.89720850
73MP0000716_abnormal_immune_system0.89531735
74MP0001790_abnormal_immune_system0.89518313
75MP0005387_immune_system_phenotype0.89518313
76MP0005253_abnormal_eye_physiology0.89062890
77MP0005389_reproductive_system_phenotype0.87297267
78MP0005464_abnormal_platelet_physiology0.87226497
79MP0001986_abnormal_taste_sensitivity0.86580355
80MP0003646_muscle_fatigue0.86128309
81MP0001119_abnormal_female_reproductive0.83675082
82MP0003119_abnormal_digestive_system0.80560126
83MP0010386_abnormal_urinary_bladder0.80019865
84MP0002282_abnormal_trachea_morphology0.79461363
85MP0006035_abnormal_mitochondrial_morpho0.79391950
86MP0000013_abnormal_adipose_tissue0.78450756
87MP0002210_abnormal_sex_determination0.76400752
88MP0005379_endocrine/exocrine_gland_phen0.76328025
89MP0009764_decreased_sensitivity_to0.75377102
90MP0001765_abnormal_ion_homeostasis0.72093725
91MP0001293_anophthalmia0.71666821
92MP0000685_abnormal_immune_system0.71427248
93MP0002733_abnormal_thermal_nociception0.69468224
94MP0002429_abnormal_blood_cell0.69248765
95MP0002067_abnormal_sensory_capabilities0.67237369
96MP0003137_abnormal_impulse_conducting0.65423983
97MP0001970_abnormal_pain_threshold0.64932324
98MP0009745_abnormal_behavioral_response0.63541744
99MP0003936_abnormal_reproductive_system0.63532761
100MP0002405_respiratory_system_inflammati0.61647819

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)4.29970218
2Severe combined immunodeficiency (HP:0004430)4.27120298
3Acute necrotizing encephalopathy (HP:0006965)3.80115527
4Decreased activity of mitochondrial respiratory chain (HP:0008972)3.70981715
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.70981715
6Testicular atrophy (HP:0000029)3.50260476
7Combined immunodeficiency (HP:0005387)3.47337655
8Thyroiditis (HP:0100646)3.46663301
9Congenital, generalized hypertrichosis (HP:0004540)3.43494232
10Abnormal mitochondria in muscle tissue (HP:0008316)3.31587176
11Methylmalonic acidemia (HP:0002912)3.29174993
12Mitochondrial inheritance (HP:0001427)3.28049713
13Increased hepatocellular lipid droplets (HP:0006565)3.27834792
14T lymphocytopenia (HP:0005403)3.26556257
15Abnormality of T cell number (HP:0011839)3.13228445
16IgG deficiency (HP:0004315)3.05709704
17Increased intramyocellular lipid droplets (HP:0012240)3.05071657
18Abnormality of midbrain morphology (HP:0002418)3.03691669
19Molar tooth sign on MRI (HP:0002419)3.03691669
20Progressive macrocephaly (HP:0004481)2.99668476
21Pancreatic cysts (HP:0001737)2.96253517
22Acute encephalopathy (HP:0006846)2.93187246
23Abnormality of DNA repair (HP:0003254)2.89373294
24Lipid accumulation in hepatocytes (HP:0006561)2.86720766
25Congenital stationary night blindness (HP:0007642)2.86352710
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.85937177
27Increased CSF lactate (HP:0002490)2.85037766
28Bile duct proliferation (HP:0001408)2.80496850
29Abnormal biliary tract physiology (HP:0012439)2.80496850
30Renal Fanconi syndrome (HP:0001994)2.76003827
31Ketoacidosis (HP:0001993)2.72910014
32Abnormality of eosinophils (HP:0001879)2.68538624
33Abnormal number of erythroid precursors (HP:0012131)2.62018500
34Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.60782876
35Methylmalonic aciduria (HP:0012120)2.56250811
36Ketosis (HP:0001946)2.54949945
37Pancreatic fibrosis (HP:0100732)2.51193088
38Abnormality of the vitamin B12 metabolism (HP:0004341)2.45029230
39Homocystinuria (HP:0002156)2.44240765
40Abnormality of homocysteine metabolism (HP:0010919)2.44240765
41Aplasia/hypoplasia of the uterus (HP:0008684)2.41647113
42Metaphyseal dysplasia (HP:0100255)2.41058626
43Entropion (HP:0000621)2.38519021
44Cerebral edema (HP:0002181)2.38500662
45Increased muscle lipid content (HP:0009058)2.37334652
46Gout (HP:0001997)2.34781530
47Abolished electroretinogram (ERG) (HP:0000550)2.34089758
48Hypoplasia of the uterus (HP:0000013)2.34048503
49Prostate neoplasm (HP:0100787)2.33878590
50Abnormality of cells of the erythroid lineage (HP:0012130)2.32954192
51Renal cortical cysts (HP:0000803)2.31650042
52Dicarboxylic aciduria (HP:0003215)2.28099988
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.28099988
54True hermaphroditism (HP:0010459)2.26387653
55Elevated erythrocyte sedimentation rate (HP:0003565)2.26029467
56Abnormality of vitamin B metabolism (HP:0004340)2.25606733
57Dyschromatopsia (HP:0007641)2.23208837
58Hypoproteinemia (HP:0003075)2.22381099
59Abnormality of T cells (HP:0002843)2.22336899
60Stenosis of the external auditory canal (HP:0000402)2.22203076
61Megaloblastic anemia (HP:0001889)2.21489654
62Spastic paraparesis (HP:0002313)2.21416679
63Generalized aminoaciduria (HP:0002909)2.12905764
64Abnormality of macular pigmentation (HP:0008002)2.12087111
65Abnormality of the prostate (HP:0008775)2.12071253
66Panhypogammaglobulinemia (HP:0003139)2.08302855
67Sparse eyelashes (HP:0000653)2.05951555
68Hypothermia (HP:0002045)2.04721405
69Metabolic alkalosis (HP:0200114)2.03010581
70Exertional dyspnea (HP:0002875)2.02773994
71Abnormality of the renal cortex (HP:0011035)2.01283893
72Optic disc pallor (HP:0000543)1.99396325
73Hepatocellular necrosis (HP:0001404)1.94301874
74Encephalitis (HP:0002383)1.93310760
75Lethargy (HP:0001254)1.92329550
76Abnormal delayed hypersensitivity skin test (HP:0002963)1.90143358
77Abnormal rod and cone electroretinograms (HP:0008323)1.89928866
78Flat capital femoral epiphysis (HP:0003370)1.89664912
79Delayed CNS myelination (HP:0002188)1.88444892
80Unilateral renal agenesis (HP:0000122)1.88183360
81CNS hypomyelination (HP:0003429)1.87620928
82Carpal bone hypoplasia (HP:0001498)1.87015921
83Absent rod-and cone-mediated responses on ERG (HP:0007688)1.84781104
84Colon cancer (HP:0003003)1.84251108
85Increased serum lactate (HP:0002151)1.81915196
86Lactic acidosis (HP:0003128)1.81369360
87Bifid tongue (HP:0010297)1.79428333
88Hepatic necrosis (HP:0002605)1.79026322
89Cerebral hypomyelination (HP:0006808)1.78258520
90Abnormality of urine glucose concentration (HP:0011016)1.76621097
91Glycosuria (HP:0003076)1.76621097
92Tachypnea (HP:0002789)1.76170444
93Autoimmune hemolytic anemia (HP:0001890)1.75650584
94Shawl scrotum (HP:0000049)1.73641578
95Exercise intolerance (HP:0003546)1.73241726
96Type 2 muscle fiber atrophy (HP:0003554)1.72811312
97Hypokalemic alkalosis (HP:0001949)1.72403758
98Leukocytosis (HP:0001974)1.72188811
99Abnormal number of incisors (HP:0011064)1.69871561
100Eosinophilia (HP:0001880)1.69023399

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.97756027
2TXK3.67568551
3STK163.62700697
4ZAK3.55995654
5TESK23.38585373
6KDR3.10018846
7NUAK12.95052982
8TAOK32.64520853
9BUB12.63222616
10ADRBK22.39087191
11MAPKAPK32.30257875
12MUSK2.25544581
13TAF12.08087025
14EIF2AK32.02983088
15TRIM281.98408599
16GRK11.91907631
17VRK11.86473870
18CDC71.82236880
19BMPR1B1.74540233
20TNIK1.69660578
21SRPK11.66278272
22MAPKAPK51.61667692
23EEF2K1.56466606
24PIK3CA1.46216733
25MAP4K21.45167664
26DYRK21.37871379
27MAP3K121.36089031
28EIF2AK11.34392839
29PLK31.33408872
30EIF2AK21.26105895
31TRPM71.25860995
32WNK41.24651588
33NEK11.23929697
34MST41.18361342
35TLK11.11769281
36MYLK1.02940890
37GRK50.96859237
38BRSK20.93531783
39RPS6KB20.92879113
40NME10.92164123
41ITK0.91879136
42PLK20.88899413
43FRK0.87614858
44SMG10.87184343
45MAPK130.84471553
46LIMK10.83152468
47PRKCQ0.80104249
48AKT30.79319742
49MAP3K140.78374756
50MAP4K10.76813499
51SCYL20.75611698
52MATK0.74369795
53TBK10.72555653
54ADRBK10.72204883
55BCR0.71062467
56CSF1R0.70747809
57GRK70.68492674
58TIE10.67953169
59MAPK110.67699215
60BCKDK0.63683790
61TTK0.61826809
62WNK30.58302905
63MAP3K110.56806129
64DAPK10.56752240
65LCK0.54258194
66FES0.52824353
67CSNK1G30.51096750
68INSRR0.50699092
69AURKA0.49736239
70CASK0.49116012
71CHEK20.48736837
72CDK90.48516808
73PHKG10.46686042
74PHKG20.46686042
75NTRK10.45893662
76CLK10.44599008
77MAP2K60.44358686
78DAPK30.43013402
79SYK0.42720499
80IGF1R0.42226353
81CSNK1G20.41837737
82PBK0.41194163
83CSNK2A10.39716966
84CSNK1A1L0.39559540
85IKBKE0.38706890
86PLK10.38218299
87AURKB0.36474286
88CSNK1G10.36236375
89PLK40.36135561
90ERBB30.36071725
91GRK60.35834428
92ACVR1B0.35143373
93JAK10.33033992
94TEC0.31485932
95MAP3K40.30809426
96LRRK20.29379278
97PRKCE0.28893332
98BMPR20.28397717
99PINK10.27511076
100IKBKB0.27177870

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.48151828
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.00021644
3Oxidative phosphorylation_Homo sapiens_hsa001903.43499898
4Primary immunodeficiency_Homo sapiens_hsa053403.14531821
5Parkinsons disease_Homo sapiens_hsa050122.83151960
6Ribosome_Homo sapiens_hsa030102.42808696
7Graft-versus-host disease_Homo sapiens_hsa053322.25899049
8Protein export_Homo sapiens_hsa030602.24250958
9Nitrogen metabolism_Homo sapiens_hsa009102.16439709
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.05363808
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.05101060
12Butanoate metabolism_Homo sapiens_hsa006502.04494051
13Autoimmune thyroid disease_Homo sapiens_hsa053202.01538760
14Caffeine metabolism_Homo sapiens_hsa002322.00846334
15Mismatch repair_Homo sapiens_hsa034302.00344122
16Nucleotide excision repair_Homo sapiens_hsa034201.91522094
17Alzheimers disease_Homo sapiens_hsa050101.91302285
18Allograft rejection_Homo sapiens_hsa053301.90735143
19RNA polymerase_Homo sapiens_hsa030201.79004926
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78863428
21Huntingtons disease_Homo sapiens_hsa050161.78741397
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.76018934
23Rheumatoid arthritis_Homo sapiens_hsa053231.73374316
24DNA replication_Homo sapiens_hsa030301.67318121
25Homologous recombination_Homo sapiens_hsa034401.67251406
26Antigen processing and presentation_Homo sapiens_hsa046121.55562970
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.53661480
28Asthma_Homo sapiens_hsa053101.42958968
29Linoleic acid metabolism_Homo sapiens_hsa005911.42232525
30Type I diabetes mellitus_Homo sapiens_hsa049401.40233265
31RNA degradation_Homo sapiens_hsa030181.39761388
32Hematopoietic cell lineage_Homo sapiens_hsa046401.38604633
33Fanconi anemia pathway_Homo sapiens_hsa034601.34625029
34Cardiac muscle contraction_Homo sapiens_hsa042601.33341725
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27817121
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26876560
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.26144172
38Spliceosome_Homo sapiens_hsa030401.26102916
39Tryptophan metabolism_Homo sapiens_hsa003801.15186511
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03697737
41Non-homologous end-joining_Homo sapiens_hsa034501.02529559
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00143592
43RNA transport_Homo sapiens_hsa030131.00090305
44Propanoate metabolism_Homo sapiens_hsa006400.99053744
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94934009
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89825803
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89332187
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86253609
49One carbon pool by folate_Homo sapiens_hsa006700.84250698
50Chemical carcinogenesis_Homo sapiens_hsa052040.78507791
51Olfactory transduction_Homo sapiens_hsa047400.73122639
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71049147
53African trypanosomiasis_Homo sapiens_hsa051430.70577888
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70189364
55Malaria_Homo sapiens_hsa051440.70136407
56Purine metabolism_Homo sapiens_hsa002300.70078146
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69087243
58Pyrimidine metabolism_Homo sapiens_hsa002400.67564933
59Peroxisome_Homo sapiens_hsa041460.67390796
60Retinol metabolism_Homo sapiens_hsa008300.66242148
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64902262
62Measles_Homo sapiens_hsa051620.60314987
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58578218
64Ether lipid metabolism_Homo sapiens_hsa005650.57379811
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57194896
66Basal transcription factors_Homo sapiens_hsa030220.56533201
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56410818
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.55959985
69Fat digestion and absorption_Homo sapiens_hsa049750.55016707
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.54318646
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53986646
72Phototransduction_Homo sapiens_hsa047440.51816127
73Metabolic pathways_Homo sapiens_hsa011000.51565468
74Selenocompound metabolism_Homo sapiens_hsa004500.50405561
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.50279045
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50202144
77Systemic lupus erythematosus_Homo sapiens_hsa053220.46779268
78N-Glycan biosynthesis_Homo sapiens_hsa005100.45322604
79T cell receptor signaling pathway_Homo sapiens_hsa046600.44697341
80Collecting duct acid secretion_Homo sapiens_hsa049660.43296713
81Fatty acid degradation_Homo sapiens_hsa000710.43277995
82Glutathione metabolism_Homo sapiens_hsa004800.41365457
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40817596
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40371522
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39098375
86Arachidonic acid metabolism_Homo sapiens_hsa005900.36398336
87Pyruvate metabolism_Homo sapiens_hsa006200.35117464
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.33089943
89Herpes simplex infection_Homo sapiens_hsa051680.32783523
90Salmonella infection_Homo sapiens_hsa051320.32164042
91Viral myocarditis_Homo sapiens_hsa054160.32030155
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.30400632
93Staphylococcus aureus infection_Homo sapiens_hsa051500.30369951
94Epstein-Barr virus infection_Homo sapiens_hsa051690.27828519
95Vitamin digestion and absorption_Homo sapiens_hsa049770.26918551
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26096041
97p53 signaling pathway_Homo sapiens_hsa041150.23615841
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.23086809
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22956897
100Salivary secretion_Homo sapiens_hsa049700.21288404

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