ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	adaptation of signaling pathway (GO:0023058)	6.33548445
2	auditory receptor cell differentiation (GO:0042491)	5.21251333
3	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	4.72620991
4	negative regulation of dendrite development (GO:2000171)	4.59478624
5	toxin metabolic process (GO:0009404)	4.44927434
6	behavioral response to nicotine (GO:0035095)	4.42146960
7	cornea development in camera-type eye (GO:0061303)	4.13986168
8	keratinocyte development (GO:0003334)	4.11107572
9	positive regulation of sodium ion transmembrane transport (GO:1902307)	4.05226347
10	retinal cone cell development (GO:0046549)	3.91767793
11	negative regulation of protein oligomerization (GO:0032460)	3.91048001
12	central nervous system projection neuron axonogenesis (GO:0021952)	3.86714470
13	protein K11-linked deubiquitination (GO:0035871)	3.80858151
14	protein prenylation (GO:0018342)	3.76351166
15	prenylation (GO:0097354)	3.76351166
16	negative regulation of activin receptor signaling pathway (GO:0032926)	3.68840822
17	DNA deamination (GO:0045006)	3.65568002
18	appendage development (GO:0048736)	3.64814362
19	limb development (GO:0060173)	3.64814362
20	proline transport (GO:0015824)	3.56546532
21	hindbrain development (GO:0030902)	3.53337160
22	cytidine deamination (GO:0009972)	3.52895800
23	cytidine metabolic process (GO:0046087)	3.52895800
24	cytidine catabolic process (GO:0006216)	3.52895800
25	pyrimidine nucleobase catabolic process (GO:0006208)	3.50637987
26	catecholamine transport (GO:0051937)	3.47136581
27	water-soluble vitamin biosynthetic process (GO:0042364)	3.44912567
28	eosinophil chemotaxis (GO:0048245)	3.44636673
29	negative regulation of histone acetylation (GO:0035067)	3.42884440
30	central nervous system neuron axonogenesis (GO:0021955)	3.42661912
31	inner ear receptor cell differentiation (GO:0060113)	3.39770925
32	insulin secretion (GO:0030073)	3.36752198
33	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.33391350
34	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.33391350
35	glycerophospholipid catabolic process (GO:0046475)	3.30598686
36	negative regulation of monooxygenase activity (GO:0032769)	3.29312099
37	response to dietary excess (GO:0002021)	3.25270092
38	Golgi to endosome transport (GO:0006895)	3.22894406
39	vitamin catabolic process (GO:0009111)	3.22468885
40	fat-soluble vitamin catabolic process (GO:0042363)	3.22468885
41	regulation of regulatory T cell differentiation (GO:0045589)	3.22104094
42	cerebellar Purkinje cell layer development (GO:0021680)	3.16521167
43	vitamin biosynthetic process (GO:0009110)	3.16293941
44	nucleobase catabolic process (GO:0046113)	3.14716471
45	regulation of collateral sprouting (GO:0048670)	3.10892136
46	eosinophil migration (GO:0072677)	3.09949511
47	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.06553109
48	glial cell proliferation (GO:0014009)	2.96562382
49	neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)	2.93691497
50	positive regulation of amino acid transport (GO:0051957)	2.89584859
51	fat-soluble vitamin biosynthetic process (GO:0042362)	2.87675315
52	regulation of glucokinase activity (GO:0033131)	2.86377520
53	regulation of hexokinase activity (GO:1903299)	2.86377520
54	photoreceptor cell maintenance (GO:0045494)	2.85736238
55	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.84857171
56	endocrine pancreas development (GO:0031018)	2.82977231
57	inositol phosphate catabolic process (GO:0071545)	2.79697024
58	negative regulation of glycoprotein biosynthetic process (GO:0010561)	2.70876344
59	neuromuscular synaptic transmission (GO:0007274)	2.70069039
60	negative regulation of axon extension (GO:0030517)	2.68572677
61	regulation of protein glycosylation (GO:0060049)	2.68258170
62	vitamin D metabolic process (GO:0042359)	2.66867031
63	mannosylation (GO:0097502)	2.62898866
64	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.62159189
65	mechanoreceptor differentiation (GO:0042490)	2.62116078
66	regulation of neurotransmitter uptake (GO:0051580)	2.60985591
67	renal tubule morphogenesis (GO:0061333)	2.60172239
68	lung secretory cell differentiation (GO:0061140)	2.60064653
69	nodal signaling pathway (GO:0038092)	2.58361732
70	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.57873842
71	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.57873842
72	regulation of glutamate secretion (GO:0014048)	2.57010514
73	adult feeding behavior (GO:0008343)	2.56733861
74	arginine catabolic process (GO:0006527)	2.56665020
75	zinc ion homeostasis (GO:0055069)	2.54804462
76	phosphatidylcholine biosynthetic process (GO:0006656)	2.53662801
77	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.53225563
78	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.52137622
79	glycosphingolipid biosynthetic process (GO:0006688)	2.51480269
80	alanine transport (GO:0032328)	2.51338631
81	hair cell differentiation (GO:0035315)	2.50819634
82	regulation of protein kinase C signaling (GO:0090036)	2.50281252
83	negative regulation of peptidyl-lysine acetylation (GO:2000757)	2.47682770
84	startle response (GO:0001964)	2.46532876
85	negative regulation of protein autophosphorylation (GO:0031953)	2.45476776
86	dopamine transport (GO:0015872)	2.45094001
87	sympathetic nervous system development (GO:0048485)	2.41964820
88	limb bud formation (GO:0060174)	2.41570064
89	replication fork processing (GO:0031297)	2.40218662
90	cardiolipin metabolic process (GO:0032048)	2.39745752
91	peptide hormone processing (GO:0016486)	2.39696160
92	sensory perception of light stimulus (GO:0050953)	2.39398571
93	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.37023721
94	protein polyglutamylation (GO:0018095)	2.36865452
95	dendrite development (GO:0016358)	2.36775869
96	presynaptic membrane assembly (GO:0097105)	2.36740921
97	regulation of action potential (GO:0098900)	2.36711711
98	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.35992605
99	estrogen biosynthetic process (GO:0006703)	2.34550613
100	cellular ketone body metabolic process (GO:0046950)	2.33376535

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	6.92465806
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.25623776
3	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.02219198
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.81007435
5	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.59544226
6	GATA1_22025678_ChIP-Seq_K562_Human	2.54488593
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.35730050
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.30961896
9	VDR_22108803_ChIP-Seq_LS180_Human	2.20175248
10	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.05163756
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.97532879
12	P300_19829295_ChIP-Seq_ESCs_Human	1.94744078
13	TAF15_26573619_Chip-Seq_HEK293_Human	1.93195277
14	SMAD4_21799915_ChIP-Seq_A2780_Human	1.92615073
15	ZNF274_21170338_ChIP-Seq_K562_Hela	1.90186851
16	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.84183146
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.83292948
18	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.81723455
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.81280762
20	FUS_26573619_Chip-Seq_HEK293_Human	1.80426478
21	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.80077113
22	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.78426252
23	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.71064779
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.69074749
25	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.61031458
26	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.56739179
27	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.53530236
28	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.52439470
29	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.52425558
30	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.51334892
31	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.50779236
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.50179429
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.50179429
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49911240
35	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.49617836
36	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.48876112
37	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.48826859
38	EWS_26573619_Chip-Seq_HEK293_Human	1.48240332
39	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.47099909
40	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.43755331
41	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.42583463
42	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.39537275
43	HTT_18923047_ChIP-ChIP_STHdh_Human	1.39203183
44	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.39050522
45	STAT3_23295773_ChIP-Seq_U87_Human	1.38361816
46	BCAT_22108803_ChIP-Seq_LS180_Human	1.37000302
47	ER_23166858_ChIP-Seq_MCF-7_Human	1.36563807
48	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.36493783
49	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.36493783
50	P53_22387025_ChIP-Seq_ESCs_Mouse	1.34508895
51	REST_21632747_ChIP-Seq_MESCs_Mouse	1.34146497
52	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.33969805
53	EZH2_22144423_ChIP-Seq_EOC_Human	1.33360747
54	TCF4_23295773_ChIP-Seq_U87_Human	1.33348226
55	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.29018532
56	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.28810466
57	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.27767220
58	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.26000112
59	AR_25329375_ChIP-Seq_VCAP_Human	1.24734413
60	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.24631480
61	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.24118572
62	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.23842569
63	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.23441989
64	ETV1_20927104_ChIP-Seq_GIST48_Human	1.23131099
65	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.20876316
66	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.20861150
67	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.18651280
68	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.18535141
69	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.18508939
70	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.17496841
71	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.15494251
72	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.15278381
73	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.14529323
74	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.14416358
75	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.13941249
76	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.13678213
77	RNF2_27304074_Chip-Seq_NSC_Mouse	1.13660571
78	TBL1_22424771_ChIP-Seq_293T_Human	1.12984246
79	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.11193770
80	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.11108339
81	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.10993816
82	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.10254947
83	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.10124562
84	NFYA_21822215_ChIP-Seq_K562_Human	1.10035427
85	SOX2_19829295_ChIP-Seq_ESCs_Human	1.09722596
86	NANOG_19829295_ChIP-Seq_ESCs_Human	1.09722596
87	CDX2_22108803_ChIP-Seq_LS180_Human	1.09224235
88	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08514513
89	NFYB_21822215_ChIP-Seq_K562_Human	1.08317246
90	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.08248102
91	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.08204526
92	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.07614656
93	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07530246
94	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.06564012
95	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.06198459
96	P300_18555785_Chip-Seq_ESCs_Mouse	1.05840188
97	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04906271
98	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.04614919
99	RBPJ_21746931_ChIP-Seq_IB4_Human	1.04490285
100	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.04338173

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005645_abnormal_hypothalamus_physiol	3.73385361
2	MP0009780_abnormal_chondrocyte_physiolo	3.65674266
3	MP0002638_abnormal_pupillary_reflex	3.65284546
4	MP0002837_dystrophic_cardiac_calcinosis	3.52044427
5	MP0000372_irregular_coat_pigmentation	3.11481081
6	MP0005551_abnormal_eye_electrophysiolog	2.54011468
7	MP0005253_abnormal_eye_physiology	2.51273332
8	MP0006276_abnormal_autonomic_nervous	2.17376076
9	MP0005386_behavior/neurological_phenoty	2.11608300
10	MP0004924_abnormal_behavior	2.11608300
11	MP0001968_abnormal_touch/_nociception	2.07358137
12	MP0008877_abnormal_DNA_methylation	2.00279632
13	MP0001944_abnormal_pancreas_morphology	1.95973474
14	MP0004270_analgesia	1.89905928
15	MP0006072_abnormal_retinal_apoptosis	1.88730472
16	MP0003195_calcinosis	1.87980283
17	MP0001485_abnormal_pinna_reflex	1.87349492
18	MP0001502_abnormal_circadian_rhythm	1.85027393
19	MP0002822_catalepsy	1.82940745
20	MP0003646_muscle_fatigue	1.81599508
21	MP0003787_abnormal_imprinting	1.75226449
22	MP0010386_abnormal_urinary_bladder	1.67900610
23	MP0000427_abnormal_hair_cycle	1.62925453
24	MP0003878_abnormal_ear_physiology	1.60508272
25	MP0005377_hearing/vestibular/ear_phenot	1.60508272
26	MP0002751_abnormal_autonomic_nervous	1.59835188
27	MP0002876_abnormal_thyroid_physiology	1.57204769
28	MP0006054_spinal_hemorrhage	1.57061714
29	MP0009046_muscle_twitch	1.56748662
30	MP0005367_renal/urinary_system_phenotyp	1.55724118
31	MP0000516_abnormal_urinary_system	1.55724118
32	MP0002736_abnormal_nociception_after	1.53834569
33	MP0010234_abnormal_vibrissa_follicle	1.51814239
34	MP0005379_endocrine/exocrine_gland_phen	1.50739377
35	MP0003890_abnormal_embryonic-extraembry	1.49004788
36	MP0000647_abnormal_sebaceous_gland	1.48528286
37	MP0003786_premature_aging	1.47310128
38	MP0002938_white_spotting	1.44233877
39	MP0001664_abnormal_digestion	1.43640886
40	MP0000631_abnormal_neuroendocrine_gland	1.42800133
41	MP0003122_maternal_imprinting	1.38789648
42	MP0005174_abnormal_tail_pigmentation	1.37349338
43	MP0001984_abnormal_olfaction	1.37256336
44	MP0003121_genomic_imprinting	1.37237821
45	MP0002734_abnormal_mechanical_nocicepti	1.36264823
46	MP0009745_abnormal_behavioral_response	1.35693783
47	MP0005365_abnormal_bile_salt	1.32356937
48	MP0008995_early_reproductive_senescence	1.30385987
49	MP0000013_abnormal_adipose_tissue	1.29917109
50	MP0005187_abnormal_penis_morphology	1.26949698
51	MP0002693_abnormal_pancreas_physiology	1.23714353
52	MP0010329_abnormal_lipoprotein_level	1.20414888
53	MP0003011_delayed_dark_adaptation	1.19738056
54	MP0002229_neurodegeneration	1.17900539
55	MP0002064_seizures	1.16797873
56	MP0002272_abnormal_nervous_system	1.16718091
57	MP0005646_abnormal_pituitary_gland	1.12691157
58	MP0002163_abnormal_gland_morphology	1.12629055
59	MP0001486_abnormal_startle_reflex	1.12419354
60	MP0003868_abnormal_feces_composition	1.12089774
61	MP0002067_abnormal_sensory_capabilities	1.10952017
62	MP0001501_abnormal_sleep_pattern	1.10562298
63	MP0002102_abnormal_ear_morphology	1.09936145
64	MP0008961_abnormal_basal_metabolism	1.09457142
65	MP0001756_abnormal_urination	1.09410714
66	MP0008872_abnormal_physiological_respon	1.07801060
67	MP0001529_abnormal_vocalization	1.04130894
68	MP0003137_abnormal_impulse_conducting	1.03034454
69	MP0003950_abnormal_plasma_membrane	1.02879015
70	MP0002572_abnormal_emotion/affect_behav	1.01400055
71	MP0002557_abnormal_social/conspecific_i	0.99863981
72	MP0005332_abnormal_amino_acid	0.98271146
73	MP0005391_vision/eye_phenotype	0.98257300
74	MP0002234_abnormal_pharynx_morphology	0.97889661
75	MP0004085_abnormal_heartbeat	0.97629107
76	MP0005535_abnormal_body_temperature	0.95243284
77	MP0002063_abnormal_learning/memory/cond	0.92806035
78	MP0005195_abnormal_posterior_eye	0.89838571
79	MP0004084_abnormal_cardiac_muscle	0.89726772
80	MP0003635_abnormal_synaptic_transmissio	0.89424622
81	MP0002078_abnormal_glucose_homeostasis	0.88772190
82	MP0003119_abnormal_digestive_system	0.88668496
83	MP0004742_abnormal_vestibular_system	0.87942963
84	MP0000003_abnormal_adipose_tissue	0.87496357
85	MP0000778_abnormal_nervous_system	0.86073657
86	MP0001765_abnormal_ion_homeostasis	0.86021119
87	MP0001324_abnormal_eye_pigmentation	0.85052676
88	MP0004142_abnormal_muscle_tone	0.84633084
89	MP0003567_abnormal_fetal_cardiomyocyte	0.84141661
90	MP0003283_abnormal_digestive_organ	0.84082115
91	MP0003953_abnormal_hormone_level	0.83836245
92	MP0005636_abnormal_mineral_homeostasis	0.82176930
93	MP0001970_abnormal_pain_threshold	0.78708035
94	MP0002735_abnormal_chemical_nociception	0.78669628
95	MP0001661_extended_life_span	0.77870329
96	MP0002069_abnormal_eating/drinking_beha	0.77553003
97	MP0005084_abnormal_gallbladder_morpholo	0.77309298
98	MP0002882_abnormal_neuron_morphology	0.76298997
99	MP0004145_abnormal_muscle_electrophysio	0.74915959
100	MP0004019_abnormal_vitamin_homeostasis	0.74807348

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Intestinal atresia (HP:0011100)	6.22688550
2	Generalized aminoaciduria (HP:0002909)	4.79877670
3	Hyperventilation (HP:0002883)	4.25123736
4	3-Methylglutaconic aciduria (HP:0003535)	4.13054124
5	Posterior subcapsular cataract (HP:0007787)	4.02504476
6	Constricted visual fields (HP:0001133)	3.81526507
7	Renal cortical cysts (HP:0000803)	3.49198236
8	Flat occiput (HP:0005469)	3.45590933
9	Hemiparesis (HP:0001269)	3.33923842
10	Nephronophthisis (HP:0000090)	3.27911291
11	Thyroiditis (HP:0100646)	3.20773286
12	Acute necrotizing encephalopathy (HP:0006965)	3.16941237
13	Pancreatic cysts (HP:0001737)	3.06815919
14	Progressive macrocephaly (HP:0004481)	3.05143248
15	Molar tooth sign on MRI (HP:0002419)	3.05092552
16	Abnormality of midbrain morphology (HP:0002418)	3.05092552
17	Absent speech (HP:0001344)	3.04607544
18	Tubulointerstitial nephritis (HP:0001970)	3.04460154
19	Protruding tongue (HP:0010808)	3.02932311
20	Hypothermia (HP:0002045)	2.98853116
21	Subcapsular cataract (HP:0000523)	2.95481575
22	Ependymoma (HP:0002888)	2.94359604
23	Fair hair (HP:0002286)	2.90501329
24	True hermaphroditism (HP:0010459)	2.83691163
25	Gastrointestinal atresia (HP:0002589)	2.75645644
26	Abnormality of chromosome segregation (HP:0002916)	2.74481271
27	Abnormality of the renal medulla (HP:0100957)	2.71441099
28	Pancreatic fibrosis (HP:0100732)	2.63949583
29	Abnormal mitochondria in muscle tissue (HP:0008316)	2.63515799
30	Acute encephalopathy (HP:0006846)	2.62122184
31	Exotropia (HP:0000577)	2.53028751
32	Tubular atrophy (HP:0000092)	2.52591726
33	Abnormality of the renal cortex (HP:0011035)	2.52248500
34	Poor head control (HP:0002421)	2.51364448
35	Progressive microcephaly (HP:0000253)	2.51224769
36	Hypoproteinemia (HP:0003075)	2.50436649
37	Clumsiness (HP:0002312)	2.50189408
38	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.49337814
39	Progressive cerebellar ataxia (HP:0002073)	2.45968819
40	Congenital stationary night blindness (HP:0007642)	2.41104817
41	Tubulointerstitial abnormality (HP:0001969)	2.40571739
42	Broad-based gait (HP:0002136)	2.35236107
43	Cerebral edema (HP:0002181)	2.29001186
44	Attenuation of retinal blood vessels (HP:0007843)	2.28375050
45	Glioma (HP:0009733)	2.27126901
46	Mitochondrial inheritance (HP:0001427)	2.26712075
47	Generalized hypopigmentation of hair (HP:0011358)	2.24911034
48	Abnormality of the astrocytes (HP:0100707)	2.23098279
49	Astrocytoma (HP:0009592)	2.23098279
50	Hematochezia (HP:0002573)	2.21868876
51	Congenital sensorineural hearing impairment (HP:0008527)	2.19590716
52	Focal seizures (HP:0007359)	2.18577645
53	Abnormality of renal resorption (HP:0011038)	2.17418359
54	Abolished electroretinogram (ERG) (HP:0000550)	2.15834794
55	Gaze-evoked nystagmus (HP:0000640)	2.13993596
56	Dialeptic seizures (HP:0011146)	2.12050662
57	Widely spaced teeth (HP:0000687)	2.08222154
58	Lipid accumulation in hepatocytes (HP:0006561)	2.05648541
59	Focal motor seizures (HP:0011153)	2.04451499
60	Volvulus (HP:0002580)	2.01452446
61	Intellectual disability, progressive (HP:0006887)	1.97447870
62	Abnormality of vitamin B metabolism (HP:0004340)	1.96812842
63	X-linked dominant inheritance (HP:0001423)	1.96438255
64	Agitation (HP:0000713)	1.96197834
65	Small hand (HP:0200055)	1.94669187
66	Symptomatic seizures (HP:0011145)	1.94541748
67	Furrowed tongue (HP:0000221)	1.93174395
68	Thyroid carcinoma (HP:0002890)	1.92964578
69	Asymmetry of the thorax (HP:0001555)	1.91562080
70	Increased CSF lactate (HP:0002490)	1.91255537
71	Dysautonomia (HP:0002459)	1.90331891
72	Enlarged epiphyses (HP:0010580)	1.89912562
73	Abnormal rod and cone electroretinograms (HP:0008323)	1.89477912
74	Polyphagia (HP:0002591)	1.88305213
75	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.88151115
76	Optic disc pallor (HP:0000543)	1.88075806
77	Neoplasm of the heart (HP:0100544)	1.87289500
78	Bony spicule pigmentary retinopathy (HP:0007737)	1.86981595
79	Prolonged QT interval (HP:0001657)	1.86940642
80	Hypoalbuminemia (HP:0003073)	1.85242917
81	Abnormal albumin level (HP:0012116)	1.85242917
82	Increased hepatocellular lipid droplets (HP:0006565)	1.85124839
83	Drooling (HP:0002307)	1.84360829
84	Proximal tubulopathy (HP:0000114)	1.82861054
85	Widely patent fontanelles and sutures (HP:0004492)	1.82074931
86	Cystic liver disease (HP:0006706)	1.81293465
87	Poor suck (HP:0002033)	1.79047393
88	Chromsome breakage (HP:0040012)	1.78954298
89	Hyperglycemia (HP:0003074)	1.78787398
90	Sclerocornea (HP:0000647)	1.78318009
91	Abnormality of the duodenum (HP:0002246)	1.77374128
92	Amblyopia (HP:0000646)	1.76994133
93	Narrow forehead (HP:0000341)	1.75961641
94	Type II lissencephaly (HP:0007260)	1.75010410
95	Tubulointerstitial fibrosis (HP:0005576)	1.74243591
96	Hypochromic microcytic anemia (HP:0004840)	1.73963316
97	Anteriorly placed anus (HP:0001545)	1.73791667
98	Irregular vertebral endplates (HP:0003301)	1.71695373
99	Generalized tonic-clonic seizures (HP:0002069)	1.69007711
100	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.68080063

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	5.09170536
2	FRK	4.40790084
3	ZAK	3.61311678
4	TRIM28	3.47503228
5	MARK1	3.20792370
6	UHMK1	2.65764642
7	STK24	2.58506382
8	MAP4K2	2.56515751
9	ADRBK2	2.56108816
10	ACVR1B	2.27184221
11	INSRR	2.22448003
12	YES1	2.18246793
13	BMPR1B	2.09216214
14	STK16	2.02477742
15	IRAK1	1.95121067
16	TLK1	1.93179836
17	GRK1	1.91866299
18	MST4	1.80231125
19	MAPK13	1.77066235
20	PRKD3	1.72537200
21	PAK3	1.67124688
22	PLK2	1.61093486
23	IRAK2	1.40325243
24	PRKCE	1.26663274
25	FGFR2	1.24504971
26	NTRK3	1.18436225
27	PTK2B	1.17747911
28	DYRK2	1.16957206
29	MAP2K7	1.14226556
30	CSNK1G1	1.11044885
31	CSNK1G3	1.04200979
32	ILK	1.03458579
33	KSR1	1.02707120
34	STK3	1.02098180
35	LATS1	1.01492836
36	MAP3K4	0.95727402
37	PRKCZ	0.93371956
38	CSNK1A1L	0.90628947
39	MAP3K9	0.83026210
40	ADRBK1	0.80403015
41	BUB1	0.79250858
42	NUAK1	0.79178884
43	FER	0.78751203
44	CSNK1G2	0.78383003
45	MET	0.76528310
46	TAOK3	0.74859732
47	CASK	0.72066832
48	TIE1	0.69580172
49	PRKCG	0.67984920
50	STK4	0.66233506
51	PAK6	0.66143548
52	PLK3	0.65227231
53	GSK3A	0.65020132
54	GRK6	0.63797107
55	WNK1	0.63764667
56	CSNK1A1	0.63013055
57	AKT3	0.62079270
58	DAPK2	0.61978448
59	RPS6KB1	0.60958184
60	PRKCH	0.58978493
61	PINK1	0.55963836
62	CSNK1D	0.55269532
63	CAMK2D	0.55125784
64	TXK	0.53194542
65	CDK5	0.50993278
66	BRAF	0.50204830
67	PHKG1	0.49328468
68	PHKG2	0.49328468
69	ROCK1	0.49317321
70	TAOK1	0.48924483
71	PIK3CG	0.47175682
72	CAMK2A	0.44161773
73	IGF1R	0.43419098
74	KDR	0.43000072
75	TGFBR1	0.42436949
76	NTRK1	0.42020896
77	PIK3CA	0.41695405
78	MAP2K1	0.40501666
79	RAF1	0.38356374
80	GRK7	0.38271494
81	ERBB3	0.36634467
82	FES	0.36206836
83	ARAF	0.35441442
84	PRKCA	0.35342937
85	PDK1	0.33665773
86	NTRK2	0.33282893
87	GRK5	0.33121364
88	PRKCQ	0.32256475
89	SRPK1	0.30880843
90	MYLK	0.30843415
91	KSR2	0.30762156
92	PRKCI	0.29945332
93	PKN1	0.29252993
94	OBSCN	0.27581173
95	AKT2	0.26885214
96	PRKACA	0.26768571
97	SGK1	0.25737229
98	PRKG1	0.25558186
99	PRKD2	0.24345288
100	STK38L	0.23874855

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.84071859
2	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	3.52358695
3	Steroid biosynthesis_Homo sapiens_hsa00100	3.23601453
4	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	3.10616955
5	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.72668877
6	Collecting duct acid secretion_Homo sapiens_hsa04966	2.42952830
7	Fatty acid elongation_Homo sapiens_hsa00062	2.29924336
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.26614986
9	Insulin secretion_Homo sapiens_hsa04911	2.24964157
10	Butanoate metabolism_Homo sapiens_hsa00650	2.23547730
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.12462770
12	Selenocompound metabolism_Homo sapiens_hsa00450	2.07318306
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.05079998
14	Oxidative phosphorylation_Homo sapiens_hsa00190	2.02276948
15	Ether lipid metabolism_Homo sapiens_hsa00565	1.87163662
16	Nicotine addiction_Homo sapiens_hsa05033	1.86672037
17	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.76613415
18	Circadian rhythm_Homo sapiens_hsa04710	1.59063185
19	Sulfur metabolism_Homo sapiens_hsa00920	1.52387972
20	Protein export_Homo sapiens_hsa03060	1.49593588
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.48889330
22	GABAergic synapse_Homo sapiens_hsa04727	1.47283536
23	Homologous recombination_Homo sapiens_hsa03440	1.45896598
24	Non-homologous end-joining_Homo sapiens_hsa03450	1.38600010
25	Phototransduction_Homo sapiens_hsa04744	1.38276245
26	Dopaminergic synapse_Homo sapiens_hsa04728	1.37599708
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.29112236
28	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.25222744
29	Long-term depression_Homo sapiens_hsa04730	1.24556905
30	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.22451955
31	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.22245909
32	Type I diabetes mellitus_Homo sapiens_hsa04940	1.17212834
33	Rheumatoid arthritis_Homo sapiens_hsa05323	1.16945808
34	Fatty acid metabolism_Homo sapiens_hsa01212	1.13311651
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.11195261
36	Glutamatergic synapse_Homo sapiens_hsa04724	1.11037198
37	Morphine addiction_Homo sapiens_hsa05032	1.08053345
38	Alcoholism_Homo sapiens_hsa05034	1.07879699
39	Cholinergic synapse_Homo sapiens_hsa04725	1.07614691
40	Parkinsons disease_Homo sapiens_hsa05012	1.07081906
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.07029476
42	Tryptophan metabolism_Homo sapiens_hsa00380	1.04294981
43	Retinol metabolism_Homo sapiens_hsa00830	1.03720529
44	Cardiac muscle contraction_Homo sapiens_hsa04260	0.96170150
45	Circadian entrainment_Homo sapiens_hsa04713	0.94632286
46	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.93371157
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.92134632
48	Amphetamine addiction_Homo sapiens_hsa05031	0.90601246
49	Peroxisome_Homo sapiens_hsa04146	0.88794938
50	Caffeine metabolism_Homo sapiens_hsa00232	0.86141251
51	Alzheimers disease_Homo sapiens_hsa05010	0.85370968
52	ABC transporters_Homo sapiens_hsa02010	0.84935150
53	Linoleic acid metabolism_Homo sapiens_hsa00591	0.84474779
54	Vibrio cholerae infection_Homo sapiens_hsa05110	0.83644147
55	Serotonergic synapse_Homo sapiens_hsa04726	0.82181666
56	Basal transcription factors_Homo sapiens_hsa03022	0.80816660
57	Taste transduction_Homo sapiens_hsa04742	0.78431207
58	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.78015541
59	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.77482181
60	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.75387885
61	Renin secretion_Homo sapiens_hsa04924	0.72221335
62	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.71047818
63	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.68399353
64	Cocaine addiction_Homo sapiens_hsa05030	0.67629558
65	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.66245306
66	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.66047909
67	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.63021357
68	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.61756857
69	Fatty acid degradation_Homo sapiens_hsa00071	0.61042592
70	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.55706318
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55498128
72	Salivary secretion_Homo sapiens_hsa04970	0.55364422
73	Regulation of autophagy_Homo sapiens_hsa04140	0.54848391
74	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.53981575
75	Gastric acid secretion_Homo sapiens_hsa04971	0.50717032
76	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.50120444
77	Primary immunodeficiency_Homo sapiens_hsa05340	0.48919434
78	Metabolic pathways_Homo sapiens_hsa01100	0.47233822
79	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.46945270
80	cAMP signaling pathway_Homo sapiens_hsa04024	0.46831376
81	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.45582021
82	Glutathione metabolism_Homo sapiens_hsa00480	0.43409776
83	Propanoate metabolism_Homo sapiens_hsa00640	0.43260821
84	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.42370644
85	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.42249163
86	Huntingtons disease_Homo sapiens_hsa05016	0.40645622
87	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.40515430
88	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.40255765
89	Arginine biosynthesis_Homo sapiens_hsa00220	0.40211943
90	Fanconi anemia pathway_Homo sapiens_hsa03460	0.39654029
91	Purine metabolism_Homo sapiens_hsa00230	0.38054031
92	Insulin resistance_Homo sapiens_hsa04931	0.37905679
93	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.37901564
94	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.36589366
95	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.36464648
96	Olfactory transduction_Homo sapiens_hsa04740	0.35245383
97	Mineral absorption_Homo sapiens_hsa04978	0.34998205
98	Type II diabetes mellitus_Homo sapiens_hsa04930	0.34571977
99	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.34164334
100	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.33748524

HAUS1P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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