HAUS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.17268328
2CENP-A containing nucleosome assembly (GO:0034080)4.07574444
3viral mRNA export from host cell nucleus (GO:0046784)4.05628774
4DNA replication initiation (GO:0006270)4.03813376
5telomere maintenance via semi-conservative replication (GO:0032201)3.95979277
6chromatin remodeling at centromere (GO:0031055)3.95007814
7telomere maintenance via recombination (GO:0000722)3.89178179
8regulation of double-strand break repair via homologous recombination (GO:0010569)3.87751227
9kinetochore organization (GO:0051383)3.85356964
10somatic diversification of immune receptors via somatic mutation (GO:0002566)3.79086713
11somatic hypermutation of immunoglobulin genes (GO:0016446)3.79086713
12regulation of nuclear cell cycle DNA replication (GO:0033262)3.74818438
13DNA strand elongation involved in DNA replication (GO:0006271)3.74486988
14kinetochore assembly (GO:0051382)3.73139692
15termination of RNA polymerase III transcription (GO:0006386)3.72430114
16transcription elongation from RNA polymerase III promoter (GO:0006385)3.72430114
17mitotic recombination (GO:0006312)3.62925379
18DNA strand elongation (GO:0022616)3.61956766
19protein localization to kinetochore (GO:0034501)3.57670357
20DNA replication checkpoint (GO:0000076)3.56956712
21recombinational repair (GO:0000725)3.53654459
22double-strand break repair via homologous recombination (GO:0000724)3.53102673
23maturation of 5.8S rRNA (GO:0000460)3.48874711
24cullin deneddylation (GO:0010388)3.45850949
25mitotic sister chromatid segregation (GO:0000070)3.44263460
26termination of RNA polymerase I transcription (GO:0006363)3.42890068
27DNA replication-independent nucleosome organization (GO:0034724)3.40588126
28DNA replication-independent nucleosome assembly (GO:0006336)3.40588126
29somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.40247160
30somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.40247160
31isotype switching (GO:0045190)3.40247160
32protein K6-linked ubiquitination (GO:0085020)3.37234332
33regulation of DNA endoreduplication (GO:0032875)3.35432792
347-methylguanosine mRNA capping (GO:0006370)3.34594259
35sister chromatid segregation (GO:0000819)3.34217454
36DNA replication-dependent nucleosome assembly (GO:0006335)3.33892735
37DNA replication-dependent nucleosome organization (GO:0034723)3.33892735
38transcription from RNA polymerase I promoter (GO:0006360)3.33222253
39DNA double-strand break processing (GO:0000729)3.32984109
407-methylguanosine RNA capping (GO:0009452)3.31703169
41RNA capping (GO:0036260)3.31703169
42telomere maintenance via telomere lengthening (GO:0010833)3.29392782
43mitotic metaphase plate congression (GO:0007080)3.28783589
44rRNA modification (GO:0000154)3.28185454
45synapsis (GO:0007129)3.27363212
46replication fork processing (GO:0031297)3.27007492
47maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.25375769
48regulation of centriole replication (GO:0046599)3.25160411
49deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.24829486
50pseudouridine synthesis (GO:0001522)3.23431500
51transcription elongation from RNA polymerase I promoter (GO:0006362)3.23346113
52protein-cofactor linkage (GO:0018065)3.23001747
53microtubule depolymerization (GO:0007019)3.22716907
54regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.20065440
55ribosome biogenesis (GO:0042254)3.20018669
56establishment of protein localization to mitochondrial membrane (GO:0090151)3.19219638
57DNA deamination (GO:0045006)3.19006796
58centriole replication (GO:0007099)3.18778786
59regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.18361990
60intra-S DNA damage checkpoint (GO:0031573)3.17353067
61mitochondrial RNA metabolic process (GO:0000959)3.15047309
62postreplication repair (GO:0006301)3.13889735
63histone exchange (GO:0043486)3.13226246
64somatic diversification of immunoglobulins (GO:0016445)3.12970662
65nucleotide-excision repair, DNA gap filling (GO:0006297)3.12554641
66protein localization to chromosome, centromeric region (GO:0071459)3.12079200
67spliceosomal snRNP assembly (GO:0000387)3.11796704
68transcription initiation from RNA polymerase I promoter (GO:0006361)3.11310434
69transcription-coupled nucleotide-excision repair (GO:0006283)3.10940760
70purine nucleobase biosynthetic process (GO:0009113)3.09928926
71RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.09758142
72somatic recombination of immunoglobulin gene segments (GO:0016447)3.09638818
73protein deneddylation (GO:0000338)3.08033748
74L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.07858752
75nucleobase biosynthetic process (GO:0046112)3.06409392
76negative regulation of DNA-dependent DNA replication (GO:2000104)3.05313434
77histone H2A acetylation (GO:0043968)3.03757387
78regulation of centrosome cycle (GO:0046605)3.03674113
79DNA catabolic process, exonucleolytic (GO:0000738)3.00219285
80tRNA methylation (GO:0030488)2.99784997
81rRNA methylation (GO:0031167)2.98367404
82spliceosomal complex assembly (GO:0000245)2.98019335
83DNA-dependent DNA replication (GO:0006261)2.94463712
84negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.93814888
85translesion synthesis (GO:0019985)2.93176434
86rRNA processing (GO:0006364)2.92083366
87resolution of meiotic recombination intermediates (GO:0000712)2.91864863
88DNA-templated transcription, termination (GO:0006353)2.90978066
89respiratory chain complex IV assembly (GO:0008535)2.89434806
90DNA ligation (GO:0006266)2.88047301
91regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.88040368
92mitotic G2/M transition checkpoint (GO:0044818)2.87962438
93nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.87329963
94ribonucleoprotein complex biogenesis (GO:0022613)2.84897595
95mismatch repair (GO:0006298)2.84587559
96rRNA metabolic process (GO:0016072)2.84154287
97positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83361178
98anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.81856383
99regulation of centrosome duplication (GO:0010824)2.81360540
100mitotic G2 DNA damage checkpoint (GO:0007095)2.80723364
101tRNA modification (GO:0006400)2.79320697
102spindle checkpoint (GO:0031577)2.79300921
103maturation of SSU-rRNA (GO:0030490)2.78881471
104reciprocal DNA recombination (GO:0035825)2.78770196
105reciprocal meiotic recombination (GO:0007131)2.78770196
106telomere organization (GO:0032200)2.78201549
107DNA recombination (GO:0006310)2.78076172
108regulation of mitotic spindle checkpoint (GO:1903504)2.77966878
109regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.77966878
110telomere maintenance (GO:0000723)2.77512585
111histone-serine phosphorylation (GO:0035404)2.77278138
112signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.75333919
113signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.75333919
114signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.75333919
115mitotic sister chromatid cohesion (GO:0007064)2.75220266
116metaphase plate congression (GO:0051310)2.74892011
117DNA synthesis involved in DNA repair (GO:0000731)2.74042072
118meiotic chromosome segregation (GO:0045132)2.73532477
119DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73265645
120regulation of helicase activity (GO:0051095)2.72948604
121water-soluble vitamin biosynthetic process (GO:0042364)2.72507051
122cell cycle G1/S phase transition (GO:0044843)2.72439133
123G1/S transition of mitotic cell cycle (GO:0000082)2.72439133
124exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72022774
125somatic diversification of immune receptors (GO:0002200)2.71385708
126mitochondrial respiratory chain complex assembly (GO:0033108)2.70843398
127histone mRNA metabolic process (GO:0008334)2.70810953
128deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.70733893
129tRNA processing (GO:0008033)2.70607138
130double-strand break repair (GO:0006302)2.70555620
131signal transduction involved in cell cycle checkpoint (GO:0072395)2.70518240
132non-recombinational repair (GO:0000726)2.70417286
133double-strand break repair via nonhomologous end joining (GO:0006303)2.70417286
134regulation of mitotic metaphase/anaphase transition (GO:0030071)2.68847478
135negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.68680848
136negative regulation of sister chromatid segregation (GO:0033046)2.68680848
137negative regulation of mitotic sister chromatid separation (GO:2000816)2.68680848
138negative regulation of mitotic sister chromatid segregation (GO:0033048)2.68680848
139signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.68628156
140intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.68628156
141folic acid-containing compound biosynthetic process (GO:0009396)2.68040709
142attachment of spindle microtubules to kinetochore (GO:0008608)2.67898629
143DNA unwinding involved in DNA replication (GO:0006268)2.67246063
144nuclear pore organization (GO:0006999)2.67206836
145behavioral response to nicotine (GO:0035095)2.66944333
146somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.65283064
147somatic cell DNA recombination (GO:0016444)2.65283064
148establishment of integrated proviral latency (GO:0075713)2.63507852
149nuclear pore complex assembly (GO:0051292)2.62221204

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.62455552
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.09975084
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.66403059
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.60157328
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.29825568
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.12656133
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.12640717
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.09621411
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.80319058
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.77366298
11ZNF274_21170338_ChIP-Seq_K562_Hela2.74613536
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.73843559
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.73383698
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.64922382
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.61831453
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.54699251
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.51306192
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46614163
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.45418543
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44661669
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.43649529
22* VDR_23849224_ChIP-Seq_CD4+_Human2.41393144
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.38771985
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.38616263
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.28636624
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.23662592
27ELK1_19687146_ChIP-ChIP_HELA_Human2.22717274
28FOXP3_21729870_ChIP-Seq_TREG_Human2.07532550
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03782969
30* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.99814427
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.98627343
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.98444448
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95190141
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94128348
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.91490826
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.91135738
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.85411884
38VDR_22108803_ChIP-Seq_LS180_Human1.83896184
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83718542
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82982616
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.80967918
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.77214769
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.72691681
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71313435
45TTF2_22483619_ChIP-Seq_HELA_Human1.68099035
46DCP1A_22483619_ChIP-Seq_HELA_Human1.67826617
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66143986
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.65311874
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62754397
50AR_21909140_ChIP-Seq_LNCAP_Human1.61963486
51XRN2_22483619_ChIP-Seq_HELA_Human1.58571187
52EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.58278050
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57364421
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57265596
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.57156051
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55680999
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.53314770
58GABP_19822575_ChIP-Seq_HepG2_Human1.52531147
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51244174
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48930517
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47770563
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46783112
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39524733
64ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.38795186
65GBX2_23144817_ChIP-Seq_PC3_Human1.38715862
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.38254503
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38038856
68IRF1_19129219_ChIP-ChIP_H3396_Human1.37934342
69FUS_26573619_Chip-Seq_HEK293_Human1.29914159
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29272123
71P300_19829295_ChIP-Seq_ESCs_Human1.23790176
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22579901
73TAF15_26573619_Chip-Seq_HEK293_Human1.18295032
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18261342
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11701263
76EWS_26573619_Chip-Seq_HEK293_Human1.09735870
77ER_23166858_ChIP-Seq_MCF-7_Human1.08380609
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08310455
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06671949
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05721381
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04833882
82* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04365650
83POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03466403
84TP53_22573176_ChIP-Seq_HFKS_Human1.02868186
85MYC_18940864_ChIP-ChIP_HL60_Human1.02523438
86CIITA_25753668_ChIP-Seq_RAJI_Human1.02436154
87NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.98745193
88NFE2_27457419_Chip-Seq_LIVER_Mouse0.97489288
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96715201
90PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94902162
91KDM5A_27292631_Chip-Seq_BREAST_Human0.94120172
92SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94065178
93SOX2_16153702_ChIP-ChIP_HESCs_Human0.93416448
94CBP_20019798_ChIP-Seq_JUKART_Human0.92350841
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92350841
96TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91212966
97SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90953705
98KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.89353413
99KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.89353413
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.89353413
101ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88432888
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87372694
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86684494
104NANOG_16153702_ChIP-ChIP_HESCs_Human0.85941743
105E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84995154
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84888664
107EZH2_27294783_Chip-Seq_NPCs_Mouse0.84765481
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83457727
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82448305
110ELK1_22589737_ChIP-Seq_MCF10A_Human0.82049758
111GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.81135275
112* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80732352
113CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.80078773
114FOXA1_25329375_ChIP-Seq_VCAP_Human0.80053844
115FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80053844
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80006413
117TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78966811
118KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78534804
119NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.77693763
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.77598252
121* STAT3_18555785_Chip-Seq_ESCs_Mouse0.76919948
122IGF1R_20145208_ChIP-Seq_DFB_Human0.76245813
123SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.75334277
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.74933427
125* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.74281344
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.71750035

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.86455432
2MP0003693_abnormal_embryo_hatching3.81928355
3MP0008057_abnormal_DNA_replication3.81622153
4MP0001188_hyperpigmentation3.66791470
5MP0008058_abnormal_DNA_repair3.35532480
6MP0003111_abnormal_nucleus_morphology3.29476664
7MP0004957_abnormal_blastocyst_morpholog3.10577682
8MP0003077_abnormal_cell_cycle2.91774118
9MP0003136_yellow_coat_color2.83054025
10MP0008007_abnormal_cellular_replicative2.73798320
11MP0006292_abnormal_olfactory_placode2.69188399
12MP0008932_abnormal_embryonic_tissue2.47666358
13MP0003941_abnormal_skin_development2.41968262
14MP0002837_dystrophic_cardiac_calcinosis2.30659981
15MP0009379_abnormal_foot_pigmentation2.17880005
16MP0000569_abnormal_digit_pigmentation2.08012177
17MP0008877_abnormal_DNA_methylation2.04011788
18MP0005171_absent_coat_pigmentation1.96814267
19MP0006072_abnormal_retinal_apoptosis1.93399345
20MP0005409_darkened_coat_color1.86815643
21MP0000015_abnormal_ear_pigmentation1.85097641
22MP0002132_abnormal_respiratory_system1.78050670
23MP0003786_premature_aging1.77554910
24MP0008260_abnormal_autophagy1.77203608
25MP0002396_abnormal_hematopoietic_system1.75269109
26MP0009697_abnormal_copulation1.75026923
27MP0003718_maternal_effect1.73473311
28MP0002095_abnormal_skin_pigmentation1.70812529
29MP0006035_abnormal_mitochondrial_morpho1.67403093
30MP0003646_muscle_fatigue1.67228920
31MP0002938_white_spotting1.61935168
32MP0002638_abnormal_pupillary_reflex1.61242267
33MP0001529_abnormal_vocalization1.60112462
34MP0002277_abnormal_respiratory_mucosa1.55775640
35MP0001986_abnormal_taste_sensitivity1.55555272
36MP0000427_abnormal_hair_cycle1.50572647
37MP0000566_synostosis1.48952659
38MP0005253_abnormal_eye_physiology1.46645256
39MP0003787_abnormal_imprinting1.46444024
40MP0000372_irregular_coat_pigmentation1.44752450
41MP0003195_calcinosis1.44377886
42MP0004381_abnormal_hair_follicle1.44300992
43MP0000490_abnormal_crypts_of1.38063105
44MP0005075_abnormal_melanosome_morpholog1.34578952
45MP0002160_abnormal_reproductive_system1.34340609
46MP0010307_abnormal_tumor_latency1.33490194
47MP0005389_reproductive_system_phenotype1.31958783
48MP0005551_abnormal_eye_electrophysiolog1.31441824
49MP0000350_abnormal_cell_proliferation1.31086943
50MP0005174_abnormal_tail_pigmentation1.29941700
51MP0003890_abnormal_embryonic-extraembry1.28774742
52MP0005646_abnormal_pituitary_gland1.28352579
53MP0006036_abnormal_mitochondrial_physio1.26917520
54MP0002210_abnormal_sex_determination1.25383764
55MP0000358_abnormal_cell_content/1.23492511
56MP0001293_anophthalmia1.20321530
57MP0003121_genomic_imprinting1.18328454
58MP0008872_abnormal_physiological_respon1.16987869
59MP0005084_abnormal_gallbladder_morpholo1.16881715
60MP0000647_abnormal_sebaceous_gland1.15071459
61MP0002234_abnormal_pharynx_morphology1.11823207
62MP0003315_abnormal_perineum_morphology1.10394459
63MP0002736_abnormal_nociception_after1.08784311
64MP0009046_muscle_twitch1.07658515
65MP0003123_paternal_imprinting1.07571295
66MP0002102_abnormal_ear_morphology1.05607175
67MP0002163_abnormal_gland_morphology1.04587065
68MP0008789_abnormal_olfactory_epithelium1.01673959
69MP0002009_preneoplasia1.01538348
70MP0001764_abnormal_homeostasis1.01492919
71MP0001919_abnormal_reproductive_system1.01292568
72MP0003950_abnormal_plasma_membrane0.98472614
73MP0005645_abnormal_hypothalamus_physiol0.98245072
74MP0004215_abnormal_myocardial_fiber0.97271936
75MP0003943_abnormal_hepatobiliary_system0.95484191
76MP0001145_abnormal_male_reproductive0.95443869
77MP0001286_abnormal_eye_development0.94152332
78MP0002084_abnormal_developmental_patter0.93911756
79MP0005410_abnormal_fertilization0.91480619
80MP0003698_abnormal_male_reproductive0.91186627
81MP0004133_heterotaxia0.89765205
82MP0000653_abnormal_sex_gland0.88781735
83MP0010386_abnormal_urinary_bladder0.88749752
84MP0008995_early_reproductive_senescence0.88529560
85MP0000383_abnormal_hair_follicle0.88465533
86MP0001968_abnormal_touch/_nociception0.87192213
87MP0001186_pigmentation_phenotype0.87096024
88MP0003567_abnormal_fetal_cardiomyocyte0.86007545
89MP0000313_abnormal_cell_death0.85880321
90MP0003763_abnormal_thymus_physiology0.83526135
91MP0001929_abnormal_gametogenesis0.83257914
92MP0001119_abnormal_female_reproductive0.82041574
93MP0010352_gastrointestinal_tract_polyps0.81888238
94MP0005266_abnormal_metabolism0.81369623
95MP0001485_abnormal_pinna_reflex0.81044207
96MP0001730_embryonic_growth_arrest0.80282750
97MP0005380_embryogenesis_phenotype0.80240192
98MP0001672_abnormal_embryogenesis/_devel0.80240192
99MP0009333_abnormal_splenocyte_physiolog0.80224544
100MP0001697_abnormal_embryo_size0.79936210
101MP0003937_abnormal_limbs/digits/tail_de0.79093949
102MP0002751_abnormal_autonomic_nervous0.78696262
103MP0005391_vision/eye_phenotype0.78497014
104MP0003186_abnormal_redox_activity0.78199316
105MP0003938_abnormal_ear_development0.77069486
106MP0005395_other_phenotype0.76579823
107MP0005195_abnormal_posterior_eye0.75898149
108MP0002876_abnormal_thyroid_physiology0.75233332
109MP0000631_abnormal_neuroendocrine_gland0.74983470
110MP0002075_abnormal_coat/hair_pigmentati0.74852533
111MP0004142_abnormal_muscle_tone0.74831809
112MP0002088_abnormal_embryonic_growth/wei0.74679145
113MP0003984_embryonic_growth_retardation0.74406061
114MP0002085_abnormal_embryonic_tissue0.74307879
115MP0004782_abnormal_surfactant_physiolog0.73571128
116MP0005671_abnormal_response_to0.73379542
117MP0001542_abnormal_bone_strength0.73153575
118MP0004134_abnormal_chest_morphology0.72901393
119MP0000681_abnormal_thyroid_gland0.71264713
120MP0004197_abnormal_fetal_growth/weight/0.70310114
121MP0004147_increased_porphyrin_level0.70106020
122MP0010678_abnormal_skin_adnexa0.69883094
123MP0001177_atelectasis0.69080017
124MP0003755_abnormal_palate_morphology0.68327080
125MP0004808_abnormal_hematopoietic_stem0.68214532
126MP0002019_abnormal_tumor_incidence0.67559664
127MP0002928_abnormal_bile_duct0.66940805
128MP0000026_abnormal_inner_ear0.66258340
129MP0004145_abnormal_muscle_electrophysio0.65751630
130MP0000703_abnormal_thymus_morphology0.65542526
131MP0005379_endocrine/exocrine_gland_phen0.64411543
132MP0003806_abnormal_nucleotide_metabolis0.64298748
133MP0001545_abnormal_hematopoietic_system0.64291015
134MP0005397_hematopoietic_system_phenotyp0.64291015
135MP0006276_abnormal_autonomic_nervous0.63257762
136MP0002177_abnormal_outer_ear0.62271306
137MP0008775_abnormal_heart_ventricle0.62262280
138MP0000049_abnormal_middle_ear0.62049640
139MP0001905_abnormal_dopamine_level0.60990653
140MP0002080_prenatal_lethality0.60603673

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.92716074
2Chromsome breakage (HP:0040012)4.83656157
3Birth length less than 3rd percentile (HP:0003561)3.94248039
43-Methylglutaconic aciduria (HP:0003535)3.46927871
5Breast hypoplasia (HP:0003187)3.37703122
6Molar tooth sign on MRI (HP:0002419)3.23874959
7Abnormality of midbrain morphology (HP:0002418)3.23874959
8Abnormality of the ileum (HP:0001549)3.10979092
9Abnormality of the preputium (HP:0100587)3.08016816
10Abnormality of chromosome stability (HP:0003220)2.96199415
11Duplicated collecting system (HP:0000081)2.95793715
12Aplastic anemia (HP:0001915)2.95480243
13Abnormality of the pons (HP:0007361)2.94204733
14Meckel diverticulum (HP:0002245)2.93452327
15Cerebral hypomyelination (HP:0006808)2.90428342
16Supernumerary spleens (HP:0009799)2.87461052
17Hypoplasia of the pons (HP:0012110)2.86119164
18Ectopic kidney (HP:0000086)2.80581070
19Volvulus (HP:0002580)2.78186312
20Cerebellar dysplasia (HP:0007033)2.70077459
21True hermaphroditism (HP:0010459)2.68931584
22Type II lissencephaly (HP:0007260)2.68488650
23Pancreatic cysts (HP:0001737)2.68272382
24Abnormality of the renal collecting system (HP:0004742)2.65425311
25Nephronophthisis (HP:0000090)2.65295781
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.64384221
27Type I transferrin isoform profile (HP:0003642)2.64314200
28Reticulocytopenia (HP:0001896)2.61306771
29Pancreatic fibrosis (HP:0100732)2.60573193
30Increased CSF lactate (HP:0002490)2.51205366
31Microvesicular hepatic steatosis (HP:0001414)2.48682325
32Abnormality of the renal cortex (HP:0011035)2.48008239
33Lipid accumulation in hepatocytes (HP:0006561)2.47907777
34Abnormality of the duodenum (HP:0002246)2.47496736
35Colon cancer (HP:0003003)2.46118648
36Abnormality of the labia minora (HP:0012880)2.42837241
37Abnormality of the anterior horn cell (HP:0006802)2.38207295
38Degeneration of anterior horn cells (HP:0002398)2.38207295
39Congenital stationary night blindness (HP:0007642)2.37275196
40Nephroblastoma (Wilms tumor) (HP:0002667)2.35909933
41Patellar aplasia (HP:0006443)2.35655824
42Acute encephalopathy (HP:0006846)2.35265160
43Optic nerve coloboma (HP:0000588)2.30488739
44Progressive macrocephaly (HP:0004481)2.29230342
45Mitochondrial inheritance (HP:0001427)2.27749360
46Renal cortical cysts (HP:0000803)2.26801653
47Abnormal number of erythroid precursors (HP:0012131)2.21844417
48Impulsivity (HP:0100710)2.19955838
49Premature graying of hair (HP:0002216)2.18619541
50Abnormality of the renal medulla (HP:0100957)2.18337417
51Abnormal lung lobation (HP:0002101)2.18174275
52Bone marrow hypocellularity (HP:0005528)2.18151505
53Clubbing of toes (HP:0100760)2.16595663
54Embryonal renal neoplasm (HP:0011794)2.16505324
55Abnormality of DNA repair (HP:0003254)2.15807081
56Aplasia/Hypoplasia of the patella (HP:0006498)2.14211585
57Progressive inability to walk (HP:0002505)2.13152600
58Abnormal mitochondria in muscle tissue (HP:0008316)2.12929718
59Septo-optic dysplasia (HP:0100842)2.11588384
60Intestinal atresia (HP:0011100)2.09506663
61Type 2 muscle fiber atrophy (HP:0003554)2.07759684
62Abnormality of the septum pellucidum (HP:0007375)2.07663586
63Sloping forehead (HP:0000340)2.05933547
64Adrenal hypoplasia (HP:0000835)2.04495676
65Reduced antithrombin III activity (HP:0001976)2.04061998
66Absent radius (HP:0003974)2.03924959
67Hepatocellular necrosis (HP:0001404)2.02183729
68Duodenal stenosis (HP:0100867)2.00138411
69Small intestinal stenosis (HP:0012848)2.00138411
70Glioma (HP:0009733)1.99268960
71Small hand (HP:0200055)1.99053831
72Methylmalonic acidemia (HP:0002912)1.97674566
73Abnormality of cells of the erythroid lineage (HP:0012130)1.97610727
74Muscle fiber atrophy (HP:0100295)1.96964857
75Medulloblastoma (HP:0002885)1.96190913
76Abnormal hair whorl (HP:0010721)1.95391145
77Neoplasm of the adrenal cortex (HP:0100641)1.94367340
78Abnormality of alanine metabolism (HP:0010916)1.93748170
79Hyperalaninemia (HP:0003348)1.93748170
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93748170
81Triphalangeal thumb (HP:0001199)1.93010193
82Aplasia/Hypoplasia of the tibia (HP:0005772)1.92226311
83Absent septum pellucidum (HP:0001331)1.91678616
84Aplasia/Hypoplasia of the sternum (HP:0006714)1.91216002
85Inability to walk (HP:0002540)1.90009664
86Lissencephaly (HP:0001339)1.89747078
87Attenuation of retinal blood vessels (HP:0007843)1.89483568
88Duplication of thumb phalanx (HP:0009942)1.89478231
89Tubular atrophy (HP:0000092)1.89179784
90Myelodysplasia (HP:0002863)1.88834215
91Rough bone trabeculation (HP:0100670)1.87608727
92Pancytopenia (HP:0001876)1.87327405
93Absent forearm bone (HP:0003953)1.87292757
94Aplasia involving forearm bones (HP:0009822)1.87292757
95Hepatic necrosis (HP:0002605)1.87146582
96Meningioma (HP:0002858)1.86971487
97Poor head control (HP:0002421)1.85006260
98Nephrogenic diabetes insipidus (HP:0009806)1.83199856
99Preaxial hand polydactyly (HP:0001177)1.82723385
100Postaxial foot polydactyly (HP:0001830)1.82278098
101Horseshoe kidney (HP:0000085)1.81019350
102Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78985499
103Abnormal protein N-linked glycosylation (HP:0012347)1.78985499
104Abnormal protein glycosylation (HP:0012346)1.78985499
105Abnormal glycosylation (HP:0012345)1.78985499
106Sparse eyelashes (HP:0000653)1.78864342
107Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78851715
108Asplenia (HP:0001746)1.78451539
109Aplasia/Hypoplasia of the tongue (HP:0010295)1.78353340
110Furrowed tongue (HP:0000221)1.78255970
111Astigmatism (HP:0000483)1.77909140
112Dandy-Walker malformation (HP:0001305)1.77794184
113Ependymoma (HP:0002888)1.77139285
114Oral leukoplakia (HP:0002745)1.75887703
115Increased hepatocellular lipid droplets (HP:0006565)1.72562335
116Abnormal spermatogenesis (HP:0008669)1.71959847
117Oligohydramnios (HP:0001562)1.71343998
118Lactic acidosis (HP:0003128)1.71324463
119Abolished electroretinogram (ERG) (HP:0000550)1.71052704
120Nasolacrimal duct obstruction (HP:0000579)1.70915337
121Optic nerve hypoplasia (HP:0000609)1.70893741
122Patchy hypopigmentation of hair (HP:0011365)1.69570264
123Congenital, generalized hypertrichosis (HP:0004540)1.69183278
124Abnormality of methionine metabolism (HP:0010901)1.68928448
125Abnormal respiratory motile cilium morphology (HP:0005938)1.68222060
126Abnormal respiratory epithelium morphology (HP:0012253)1.68222060
127Capillary hemangiomas (HP:0005306)1.68157604
128Retinal dysplasia (HP:0007973)1.68060934
129Aganglionic megacolon (HP:0002251)1.67114293
130Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.66991031
131CNS hypomyelination (HP:0003429)1.66912609
132Chronic hepatic failure (HP:0100626)1.66898495
133Aplasia/hypoplasia of the uterus (HP:0008684)1.66520386
134Anencephaly (HP:0002323)1.66463144
135Abnormality of the carotid arteries (HP:0005344)1.65886216
136Agnosia (HP:0010524)1.65857489
137Absent thumb (HP:0009777)1.65514821
138Large for gestational age (HP:0001520)1.63591125
139Oculomotor apraxia (HP:0000657)1.63276676
140Medial flaring of the eyebrow (HP:0010747)1.63110636
141Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.62771695
142Arteriovenous malformation (HP:0100026)1.62698958
143Increased serum lactate (HP:0002151)1.62620104
144White forelock (HP:0002211)1.61299393
145Acute necrotizing encephalopathy (HP:0006965)1.60110206
146Sclerocornea (HP:0000647)1.58629514
147Congenital primary aphakia (HP:0007707)1.58053050
148Pendular nystagmus (HP:0012043)1.57311036
149Lymphoma (HP:0002665)1.57101917
150Protruding tongue (HP:0010808)1.56879145
151Abnormal number of incisors (HP:0011064)1.56778429

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.62549647
2STK163.26333350
3EIF2AK13.00339731
4SRPK12.97804744
5WEE12.67869646
6BUB12.61131893
7ZAK2.56336508
8MKNK22.55483126
9CASK2.49163889
10MKNK12.47196493
11ACVR1B2.26793974
12BRSK22.25989292
13PLK42.22616787
14TRIM282.13052192
15NEK12.11356444
16EIF2AK32.05025391
17VRK12.04435401
18AKT32.03670352
19YES12.01067281
20CDC71.99073130
21TSSK61.98210209
22BMPR1B1.93775077
23WNK31.76330785
24TTK1.72685820
25CDK81.68704579
26NME21.48866030
27PLK31.48185287
28VRK21.47580688
29PBK1.46857458
30EIF2AK21.43160351
31ERBB31.40358592
32TXK1.36969214
33TLK11.34970393
34PLK11.34895534
35CDK71.34773468
36TAF11.31707162
37LATS11.27684800
38STK31.25962197
39IRAK31.25737795
40ADRBK21.24162096
41ATR1.21319602
42CHEK21.17328650
43MARK11.16161563
44MAP4K21.12750975
45TNIK1.11529487
46EPHA21.06041600
47STK38L1.03744073
48AURKB1.03519512
49NEK91.03452601
50CLK11.03281974
51CDK30.99503467
52DYRK20.99153375
53PRPF4B0.99037820
54BRSK10.98457386
55NEK60.94654597
56PINK10.92892328
57PASK0.92048363
58TEC0.91464339
59CCNB10.91249911
60DYRK30.91191021
61MAP3K40.91185992
62SGK20.84701875
63STK390.82645057
64MAP2K70.82527909
65NLK0.81568375
66GRK10.81079254
67IRAK40.75057374
68WNK40.74659561
69NEK20.74202586
70MUSK0.73521525
71BCR0.72661623
72CHEK10.71629500
73AURKA0.71371715
74ATM0.68935197
75STK40.65182153
76SGK2230.64620542
77SGK4940.64620542
78MST40.63554879
79STK240.63027704
80TAOK30.62468627
81INSRR0.62393507
82CSNK2A10.61423697
83NME10.61323462
84CSNK1G20.60440964
85TGFBR10.59791739
86PNCK0.59411742
87MAP3K140.58947310
88RPS6KA40.58620281
89ERBB40.57936426
90GRK70.57845191
91CSNK2A20.55161028
92NUAK10.54946575
93PDK20.54122801
94TIE10.53306406
95ADRBK10.53268027
96CDK20.51185478
97MAPKAPK50.51131872
98RPS6KB20.50714702
99CDK190.50353591
100CSNK1G30.49512809
101RPS6KA50.47877498
102PRKCI0.47553312
103CDK10.46757438
104MARK30.45447093
105FLT30.44087565
106BRAF0.43957162
107UHMK10.42841751
108MAP3K60.40135890
109PLK20.39465874
110TAOK20.38738482
111PRKCE0.37294686
112TRPM70.36432833
113MAP3K120.35701797
114CSNK1G10.35212330
115SIK30.34451047
116PIM10.33371705
117CSNK1A1L0.32713399
118PKN10.32198919
119PIM20.32149372
120BMPR20.30993313
121MELK0.29652399
122OXSR10.29615166
123MAPK130.29597782
124BRD40.28961299
125CSNK1E0.27786237
126NTRK20.27634309
127RPS6KC10.26971943
128PRKCG0.26729187
129CSNK1D0.26445976

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.11174277
2Mismatch repair_Homo sapiens_hsa034303.79583996
3RNA polymerase_Homo sapiens_hsa030203.68778885
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.50790952
5Homologous recombination_Homo sapiens_hsa034403.37498953
6Proteasome_Homo sapiens_hsa030503.27573044
7Fanconi anemia pathway_Homo sapiens_hsa034603.03414019
8Spliceosome_Homo sapiens_hsa030403.01315535
9Nucleotide excision repair_Homo sapiens_hsa034202.69172838
10Ribosome_Homo sapiens_hsa030102.64138491
11Basal transcription factors_Homo sapiens_hsa030222.57432351
12RNA transport_Homo sapiens_hsa030132.57378219
13Base excision repair_Homo sapiens_hsa034102.49011709
14Pyrimidine metabolism_Homo sapiens_hsa002402.47281514
15Cell cycle_Homo sapiens_hsa041102.41881155
16Non-homologous end-joining_Homo sapiens_hsa034502.31349374
17Selenocompound metabolism_Homo sapiens_hsa004502.23778823
18One carbon pool by folate_Homo sapiens_hsa006702.09230581
19Protein export_Homo sapiens_hsa030602.05801921
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93076577
21RNA degradation_Homo sapiens_hsa030181.89041179
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.84453425
23Vitamin B6 metabolism_Homo sapiens_hsa007501.70902141
24Purine metabolism_Homo sapiens_hsa002301.68634767
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64678644
26p53 signaling pathway_Homo sapiens_hsa041151.54352350
27Butanoate metabolism_Homo sapiens_hsa006501.45206837
28mRNA surveillance pathway_Homo sapiens_hsa030151.44869524
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44559907
30Propanoate metabolism_Homo sapiens_hsa006401.32893859
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.12714007
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09632355
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01624803
34Epstein-Barr virus infection_Homo sapiens_hsa051691.01601910
35Nitrogen metabolism_Homo sapiens_hsa009101.01071730
36Phototransduction_Homo sapiens_hsa047440.96033327
37Huntingtons disease_Homo sapiens_hsa050160.94533289
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93126540
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91062456
40Regulation of autophagy_Homo sapiens_hsa041400.83907477
41Parkinsons disease_Homo sapiens_hsa050120.83387514
42Folate biosynthesis_Homo sapiens_hsa007900.82074937
43Arachidonic acid metabolism_Homo sapiens_hsa005900.81792038
44Sphingolipid metabolism_Homo sapiens_hsa006000.81518887
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81345354
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80279776
47Oxidative phosphorylation_Homo sapiens_hsa001900.79200451
48Systemic lupus erythematosus_Homo sapiens_hsa053220.78283344
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77787200
50Tryptophan metabolism_Homo sapiens_hsa003800.77681320
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77034411
52Fatty acid elongation_Homo sapiens_hsa000620.76613225
53Herpes simplex infection_Homo sapiens_hsa051680.75205400
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.74107772
55Pyruvate metabolism_Homo sapiens_hsa006200.73836835
56Sulfur metabolism_Homo sapiens_hsa009200.70778253
57Primary immunodeficiency_Homo sapiens_hsa053400.69745143
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.66026170
59Thyroid cancer_Homo sapiens_hsa052160.62331409
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59023606
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58598789
62Olfactory transduction_Homo sapiens_hsa047400.57144423
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56851245
64Autoimmune thyroid disease_Homo sapiens_hsa053200.54898897
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53515347
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52455625
67Viral carcinogenesis_Homo sapiens_hsa052030.52004546
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51041997
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50795325
70Oocyte meiosis_Homo sapiens_hsa041140.47035010
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46779467
72Lysine degradation_Homo sapiens_hsa003100.46423034
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.45962125
74Alcoholism_Homo sapiens_hsa050340.44608723
75N-Glycan biosynthesis_Homo sapiens_hsa005100.43904477
76Measles_Homo sapiens_hsa051620.43635777
77Ether lipid metabolism_Homo sapiens_hsa005650.43145256
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.43018605
79Hematopoietic cell lineage_Homo sapiens_hsa046400.42221232
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42211036
81Steroid biosynthesis_Homo sapiens_hsa001000.42127652
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42063881
83Caffeine metabolism_Homo sapiens_hsa002320.41419160
84Peroxisome_Homo sapiens_hsa041460.40500367
85HTLV-I infection_Homo sapiens_hsa051660.39339355
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38099337
87TGF-beta signaling pathway_Homo sapiens_hsa043500.37105644
88Metabolic pathways_Homo sapiens_hsa011000.36806209
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36651716
90Antigen processing and presentation_Homo sapiens_hsa046120.36020851
91Allograft rejection_Homo sapiens_hsa053300.34174574
92Serotonergic synapse_Homo sapiens_hsa047260.33538665
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31415536
94Asthma_Homo sapiens_hsa053100.30002290
95Basal cell carcinoma_Homo sapiens_hsa052170.29919383
96Melanoma_Homo sapiens_hsa052180.28651178
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28644777
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28261004
99MicroRNAs in cancer_Homo sapiens_hsa052060.27723311
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27034958
101Alzheimers disease_Homo sapiens_hsa050100.26539247
102Legionellosis_Homo sapiens_hsa051340.25977556
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25865635
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.25725010
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.25119821
106Cardiac muscle contraction_Homo sapiens_hsa042600.24924577
107Pathways in cancer_Homo sapiens_hsa052000.24821357
108Prostate cancer_Homo sapiens_hsa052150.24796352
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24571732
110Linoleic acid metabolism_Homo sapiens_hsa005910.23491765
111Wnt signaling pathway_Homo sapiens_hsa043100.23216593
112Apoptosis_Homo sapiens_hsa042100.23181750
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23013014
114Other glycan degradation_Homo sapiens_hsa005110.22887526
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.21528475
116Sulfur relay system_Homo sapiens_hsa041220.20097362
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.19672657
118Hepatitis B_Homo sapiens_hsa051610.19662840
119Arginine and proline metabolism_Homo sapiens_hsa003300.19311482
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18693877
121beta-Alanine metabolism_Homo sapiens_hsa004100.17803163
122Hedgehog signaling pathway_Homo sapiens_hsa043400.17733307
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17083396
124Taste transduction_Homo sapiens_hsa047420.16443217
125Glutathione metabolism_Homo sapiens_hsa004800.16128408
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16019337
127Fatty acid metabolism_Homo sapiens_hsa012120.14987778
128Collecting duct acid secretion_Homo sapiens_hsa049660.14151307
129Nicotine addiction_Homo sapiens_hsa050330.13839790
130Circadian rhythm_Homo sapiens_hsa047100.13829147
131Hippo signaling pathway_Homo sapiens_hsa043900.12425949
132Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12400351
133Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.11838834

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