HAUS5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HAUS5 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.97798726
2telomere maintenance via semi-conservative replication (GO:0032201)5.92175543
3DNA strand elongation (GO:0022616)5.70613493
4telomere maintenance via recombination (GO:0000722)5.20723013
5DNA replication initiation (GO:0006270)5.08400513
6DNA unwinding involved in DNA replication (GO:0006268)5.06178029
7mitotic recombination (GO:0006312)4.96552329
8CENP-A containing nucleosome assembly (GO:0034080)4.63326153
9protein localization to kinetochore (GO:0034501)4.60901227
10ribosomal small subunit assembly (GO:0000028)4.59229034
11DNA replication checkpoint (GO:0000076)4.55088650
12telomere maintenance via telomere lengthening (GO:0010833)4.52957834
13nucleotide-excision repair, DNA gap filling (GO:0006297)4.52114230
14chromatin remodeling at centromere (GO:0031055)4.44964403
15replication fork processing (GO:0031297)4.16924486
16DNA replication-independent nucleosome organization (GO:0034724)4.16561067
17DNA replication-independent nucleosome assembly (GO:0006336)4.16561067
18regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.14635625
19kinetochore organization (GO:0051383)4.13971102
20mitotic metaphase plate congression (GO:0007080)4.13919664
21protein localization to chromosome, centromeric region (GO:0071459)4.13803285
22mitotic chromosome condensation (GO:0007076)4.07966270
23DNA deamination (GO:0045006)4.03750068
24maturation of SSU-rRNA (GO:0030490)3.95978717
25mitotic sister chromatid segregation (GO:0000070)3.91535969
26deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.90215708
27attachment of spindle microtubules to kinetochore (GO:0008608)3.89790149
28mitochondrial respiratory chain complex assembly (GO:0033108)3.76677952
29DNA strand renaturation (GO:0000733)3.72297464
30DNA replication-dependent nucleosome organization (GO:0034723)3.71637714
31DNA replication-dependent nucleosome assembly (GO:0006335)3.71637714
32protein complex biogenesis (GO:0070271)3.71537312
33nucleobase biosynthetic process (GO:0046112)3.70044461
34histone exchange (GO:0043486)3.69375528
35mitochondrial respiratory chain complex I assembly (GO:0032981)3.69070783
36NADH dehydrogenase complex assembly (GO:0010257)3.69070783
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.69070783
38metaphase plate congression (GO:0051310)3.68281441
39sister chromatid segregation (GO:0000819)3.65823844
40kinetochore assembly (GO:0051382)3.61936351
41mitotic nuclear envelope disassembly (GO:0007077)3.59401112
42viral transcription (GO:0019083)3.53646946
43somatic hypermutation of immunoglobulin genes (GO:0016446)3.49732520
44somatic diversification of immune receptors via somatic mutation (GO:0002566)3.49732520
45regulation of DNA endoreduplication (GO:0032875)3.48304461
46establishment of chromosome localization (GO:0051303)3.47937341
47telomere maintenance (GO:0000723)3.46806658
48telomere organization (GO:0032200)3.46438342
49translational termination (GO:0006415)3.44935616
50recombinational repair (GO:0000725)3.42492805
51double-strand break repair via homologous recombination (GO:0000724)3.41564061
52protein K6-linked ubiquitination (GO:0085020)3.39025557
53purine nucleobase biosynthetic process (GO:0009113)3.35991433
54ribosomal small subunit biogenesis (GO:0042274)3.34669127
55IMP biosynthetic process (GO:0006188)3.33942743
56meiotic chromosome segregation (GO:0045132)3.31215300
57regulation of double-strand break repair via homologous recombination (GO:0010569)3.28506301
58negative regulation of mRNA processing (GO:0050686)3.28237897
59mismatch repair (GO:0006298)3.27744979
60translesion synthesis (GO:0019985)3.27466712
61base-excision repair (GO:0006284)3.27283183
62viral mRNA export from host cell nucleus (GO:0046784)3.27050920
63nuclear envelope disassembly (GO:0051081)3.25933886
64membrane disassembly (GO:0030397)3.25933886
65formation of translation preinitiation complex (GO:0001731)3.23881632
66DNA double-strand break processing (GO:0000729)3.23457904
67DNA topological change (GO:0006265)3.20830116
68transcription-coupled nucleotide-excision repair (GO:0006283)3.18405470
69translational elongation (GO:0006414)3.18105476
70DNA geometric change (GO:0032392)3.17382150
71DNA duplex unwinding (GO:0032508)3.17321481
72synapsis (GO:0007129)3.17149921
73regulation of nuclear cell cycle DNA replication (GO:0033262)3.14109127
74chromatin assembly or disassembly (GO:0006333)3.12945458
75chromatin assembly (GO:0031497)3.12685954
76DNA ligation (GO:0006266)3.12060701
77pseudouridine synthesis (GO:0001522)3.11829514
78regulation of spindle organization (GO:0090224)3.11651072
79translational initiation (GO:0006413)3.11452063
80regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.09849299
81heterochromatin organization (GO:0070828)3.08163642
82histone H2A acetylation (GO:0043968)3.06473944
83negative regulation of B cell apoptotic process (GO:0002903)3.06231701
84maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.05253302
85DNA recombination (GO:0006310)3.04631324
86DNA catabolic process, exonucleolytic (GO:0000738)3.04388074
87negative regulation of chromosome segregation (GO:0051985)3.03165370
88SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.02342019
89cell cycle G1/S phase transition (GO:0044843)3.02258709
90G1/S transition of mitotic cell cycle (GO:0000082)3.02258709
91negative regulation of mitotic sister chromatid separation (GO:2000816)3.01959583
92negative regulation of mitotic sister chromatid segregation (GO:0033048)3.01959583
93negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.01959583
94negative regulation of sister chromatid segregation (GO:0033046)3.01959583
95nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01669719
96spindle checkpoint (GO:0031577)3.01471806
97ATP-dependent chromatin remodeling (GO:0043044)3.01440997
98chromosome segregation (GO:0007059)3.01179129
99folic acid-containing compound biosynthetic process (GO:0009396)3.01101404
100IMP metabolic process (GO:0046040)3.00897664
101mitochondrial RNA metabolic process (GO:0000959)3.00299353
102postreplication repair (GO:0006301)2.99618975
103cytochrome complex assembly (GO:0017004)2.97540952
104regulation of mitochondrial translation (GO:0070129)2.97495650
105respiratory chain complex IV assembly (GO:0008535)2.96282040
106ribosomal large subunit biogenesis (GO:0042273)2.95788027
107protein localization to chromosome (GO:0034502)2.95636665
108negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.95404993
109spliceosomal complex assembly (GO:0000245)2.95317164
110histone-serine phosphorylation (GO:0035404)2.95219732
111negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.94995764
112spindle assembly checkpoint (GO:0071173)2.94711945
113pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.94607794
114cotranslational protein targeting to membrane (GO:0006613)2.94408605
115exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93882455
116DNA conformation change (GO:0071103)2.93770631
117nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.93245294
118regulation of chromosome segregation (GO:0051983)2.92873518
119mitotic cell cycle (GO:0000278)2.92719893
120ribonucleoprotein complex biogenesis (GO:0022613)2.92384709
121spliceosomal snRNP assembly (GO:0000387)2.91619398
122protein targeting to ER (GO:0045047)2.91564961
123DNA replication (GO:0006260)2.91544689
124UTP biosynthetic process (GO:0006228)2.90692173
125pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.90011105
126anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.89199625
127mitotic spindle assembly checkpoint (GO:0007094)2.89060837
128rRNA processing (GO:0006364)2.88684411
129negative regulation of mRNA metabolic process (GO:1903312)2.88195185
130negative regulation of RNA splicing (GO:0033119)2.87524521
131nuclear pore organization (GO:0006999)2.86438569
132regulation of mitotic metaphase/anaphase transition (GO:0030071)2.84881503
133pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.83231097
134base-excision repair, AP site formation (GO:0006285)2.76619775
135double-strand break repair (GO:0006302)2.76335216
136GTP biosynthetic process (GO:0006183)2.72532675
137negative regulation of DNA-dependent DNA replication (GO:2000104)2.71502067
138pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.69881844
139V(D)J recombination (GO:0033151)2.69146539
140peptidyl-histidine modification (GO:0018202)2.69022119
141DNA synthesis involved in DNA repair (GO:0000731)2.68454482
142somatic diversification of immune receptors (GO:0002200)2.67881366
143resolution of meiotic recombination intermediates (GO:0000712)2.66860431
144DNA biosynthetic process (GO:0071897)2.64852647
145regulation of DNA-dependent DNA replication (GO:0090329)2.64406182
146centriole replication (GO:0007099)2.61894367
147termination of RNA polymerase II transcription (GO:0006369)2.60198369
148somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.58699807
149somatic cell DNA recombination (GO:0016444)2.58699807
150non-recombinational repair (GO:0000726)2.58307338
151double-strand break repair via nonhomologous end joining (GO:0006303)2.58307338
152tRNA modification (GO:0006400)2.58062641
153regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.56661494

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.81580118
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.67873064
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.04203964
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.69869262
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53993064
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.45886700
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.94120724
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.75943735
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.75140374
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.61446803
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.56841101
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55980341
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55303235
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.54294703
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.52521567
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.51153407
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39506324
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.39137290
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.35656994
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.28403276
21XRN2_22483619_ChIP-Seq_HELA_Human2.19496259
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16020762
23AR_21909140_ChIP-Seq_LNCAP_Human2.15657299
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.13006493
25VDR_23849224_ChIP-Seq_CD4+_Human2.07854282
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07489071
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02933168
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02445995
29FOXP3_21729870_ChIP-Seq_TREG_Human2.02200217
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.94656683
31DCP1A_22483619_ChIP-Seq_HELA_Human1.85178612
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82315672
33MYC_22102868_ChIP-Seq_BL_Human1.81969165
34GABP_19822575_ChIP-Seq_HepG2_Human1.77541720
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77204404
36* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.75676679
37* CIITA_25753668_ChIP-Seq_RAJI_Human1.74868705
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69411517
39ZNF274_21170338_ChIP-Seq_K562_Hela1.65390861
40* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64936035
41TTF2_22483619_ChIP-Seq_HELA_Human1.64421812
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62802861
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60919964
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58757642
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.57024736
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.56123335
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55873426
48* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55544146
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54365176
50VDR_21846776_ChIP-Seq_THP-1_Human1.51204091
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51171590
52ELK1_19687146_ChIP-ChIP_HELA_Human1.48909675
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.46586235
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44609133
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44441639
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.43098837
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41909189
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41623813
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37076686
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36384553
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35321483
62KDM5A_27292631_Chip-Seq_BREAST_Human1.33782099
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33645925
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29440191
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26784382
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24332594
67SPI1_23547873_ChIP-Seq_NB4_Human1.16614605
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15086380
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14575674
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13783965
71SCL_19346495_ChIP-Seq_HPC-7_Human1.10498548
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09053079
73IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.08581168
74IRF1_19129219_ChIP-ChIP_H3396_Human1.08163704
75* FOXP1_21924763_ChIP-Seq_HESCs_Human1.08080934
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04538136
77MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03924130
78TFEB_21752829_ChIP-Seq_HELA_Human1.03900818
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03459813
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.01375240
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00234459
82NOTCH1_21737748_ChIP-Seq_TLL_Human0.97553850
83SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96450532
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95574877
85POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94715224
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94411568
87ELF1_20517297_ChIP-Seq_JURKAT_Human0.94210596
88MYC_18940864_ChIP-ChIP_HL60_Human0.93937580
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93928700
90EWS_26573619_Chip-Seq_HEK293_Human0.92487959
91EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.91933395
92GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91147684
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90395045
94RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.89291003
95IGF1R_20145208_ChIP-Seq_DFB_Human0.88947471
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88835285
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88444489
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88104630
99RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.86172253
100PHF8_20622854_ChIP-Seq_HELA_Human0.85415979
101STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84889524
102MYB_21317192_ChIP-Seq_ERMYB_Mouse0.83638332
103* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82592754
104CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81746676
105E2F1_17053090_ChIP-ChIP_MCF-7_Human0.81744899
106P68_20966046_ChIP-Seq_HELA_Human0.81133679
107* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80865481
108* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80673749
109MYB_26560356_Chip-Seq_TH2_Human0.80178321
110ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79835900
111UTX_26944678_Chip-Seq_JUKART_Human0.79412458
112MYB_26560356_Chip-Seq_TH1_Human0.78338814
113SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.78336066
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78131170
115* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.77771574
116CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.77707338
117E2F1_20622854_ChIP-Seq_HELA_Human0.76841636
118SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.76709465
119ERA_21632823_ChIP-Seq_H3396_Human0.76550309
120GATA2_22383799_ChIP-Seq_G1ME_Mouse0.76352693
121CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.75449596

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.35227962
2MP0010094_abnormal_chromosome_stability5.02810776
3MP0003111_abnormal_nucleus_morphology4.69822555
4MP0008057_abnormal_DNA_replication4.33202721
5MP0003077_abnormal_cell_cycle4.05756990
6MP0004957_abnormal_blastocyst_morpholog3.91759945
7MP0008058_abnormal_DNA_repair3.39733357
8MP0002396_abnormal_hematopoietic_system2.99846889
9MP0008007_abnormal_cellular_replicative2.92415647
10MP0008995_early_reproductive_senescence2.60460798
11MP0008932_abnormal_embryonic_tissue2.46062531
12MP0000490_abnormal_crypts_of2.27279933
13MP0004808_abnormal_hematopoietic_stem2.02604595
14MP0002160_abnormal_reproductive_system2.00149389
15MP0000350_abnormal_cell_proliferation1.94822620
16MP0008877_abnormal_DNA_methylation1.93187076
17MP0003763_abnormal_thymus_physiology1.88853041
18MP0001730_embryonic_growth_arrest1.87750700
19MP0000372_irregular_coat_pigmentation1.76457346
20MP0009697_abnormal_copulation1.76272265
21MP0005646_abnormal_pituitary_gland1.69275685
22MP0010352_gastrointestinal_tract_polyps1.68844815
23MP0003786_premature_aging1.66870760
24MP0006072_abnormal_retinal_apoptosis1.64570703
25MP0002398_abnormal_bone_marrow1.62890383
26MP0010307_abnormal_tumor_latency1.61949051
27MP0002019_abnormal_tumor_incidence1.61195739
28MP0005174_abnormal_tail_pigmentation1.60960491
29MP0005075_abnormal_melanosome_morpholog1.57262523
30MP0000703_abnormal_thymus_morphology1.50618502
31MP0000313_abnormal_cell_death1.49830270
32MP0001545_abnormal_hematopoietic_system1.47188458
33MP0005397_hematopoietic_system_phenotyp1.47188458
34MP0002249_abnormal_larynx_morphology1.47077997
35MP0002722_abnormal_immune_system1.46855716
36MP0000049_abnormal_middle_ear1.43318133
37MP0000678_abnormal_parathyroid_gland1.43039710
38MP0000689_abnormal_spleen_morphology1.42780650
39MP0005389_reproductive_system_phenotype1.40861536
40MP0001697_abnormal_embryo_size1.36862744
41MP0009333_abnormal_splenocyte_physiolog1.36673221
42MP0001346_abnormal_lacrimal_gland1.36458913
43MP0001672_abnormal_embryogenesis/_devel1.36095536
44MP0005380_embryogenesis_phenotype1.36095536
45MP0002080_prenatal_lethality1.35783181
46MP0002102_abnormal_ear_morphology1.32771965
47MP0002163_abnormal_gland_morphology1.30168432
48MP0003123_paternal_imprinting1.29018684
49MP0005671_abnormal_response_to1.28254949
50MP0002429_abnormal_blood_cell1.27782404
51MP0000631_abnormal_neuroendocrine_gland1.26115546
52MP0000465_gastrointestinal_hemorrhage1.25684167
53MP0000015_abnormal_ear_pigmentation1.25471755
54MP0002132_abnormal_respiratory_system1.24320530
55MP0006054_spinal_hemorrhage1.24241599
56MP0000685_abnormal_immune_system1.24217248
57MP0002234_abnormal_pharynx_morphology1.23903220
58MP0005645_abnormal_hypothalamus_physiol1.23053848
59MP0003984_embryonic_growth_retardation1.21536900
60MP0006292_abnormal_olfactory_placode1.19861013
61MP0005220_abnormal_exocrine_pancreas1.19573647
62MP0001800_abnormal_humoral_immune1.18821927
63MP0000716_abnormal_immune_system1.18780278
64MP0002088_abnormal_embryonic_growth/wei1.17795560
65MP0002095_abnormal_skin_pigmentation1.17102993
66MP0006035_abnormal_mitochondrial_morpho1.16586623
67MP0001835_abnormal_antigen_presentation1.14555682
68MP0003698_abnormal_male_reproductive1.13808423
69MP0008872_abnormal_physiological_respon1.13099591
70MP0002085_abnormal_embryonic_tissue1.12202310
71MP0005187_abnormal_penis_morphology1.10558691
72MP0003567_abnormal_fetal_cardiomyocyte1.10156747
73MP0001919_abnormal_reproductive_system1.09802624
74MP0003937_abnormal_limbs/digits/tail_de1.09401242
75MP0004147_increased_porphyrin_level1.09341287
76MP0002420_abnormal_adaptive_immunity1.08661415
77MP0003718_maternal_effect1.07405796
78MP0001819_abnormal_immune_cell1.05506148
79MP0000681_abnormal_thyroid_gland1.05157396
80MP0002210_abnormal_sex_determination1.04117687
81MP0002086_abnormal_extraembryonic_tissu1.03200444
82MP0005367_renal/urinary_system_phenotyp1.01495254
83MP0000516_abnormal_urinary_system1.01495254
84MP0002138_abnormal_hepatobiliary_system0.99151308
85MP0002452_abnormal_antigen_presenting0.98983619
86MP0001853_heart_inflammation0.98844170
87MP0005464_abnormal_platelet_physiology0.97798287
88MP0001764_abnormal_homeostasis0.96603893
89MP0001661_extended_life_span0.96333719
90MP0003787_abnormal_imprinting0.95784213
91MP0001293_anophthalmia0.95408987
92MP0004133_heterotaxia0.95323641
93MP0002084_abnormal_developmental_patter0.91307092
94MP0010155_abnormal_intestine_physiology0.91230936
95MP0003806_abnormal_nucleotide_metabolis0.91207555
96MP0002723_abnormal_immune_serum0.89804154
97MP0001145_abnormal_male_reproductive0.89448463
98MP0001986_abnormal_taste_sensitivity0.88354905
99MP0001929_abnormal_gametogenesis0.86962370
100MP0003943_abnormal_hepatobiliary_system0.86658690
101MP0010030_abnormal_orbit_morphology0.86526951
102MP0009379_abnormal_foot_pigmentation0.84696700
103MP0004197_abnormal_fetal_growth/weight/0.83685790
104MP0005551_abnormal_eye_electrophysiolog0.83039403
105MP0003121_genomic_imprinting0.81678442
106MP0000858_altered_metastatic_potential0.81512313
107MP0003136_yellow_coat_color0.81307161
108MP0002075_abnormal_coat/hair_pigmentati0.81055294
109MP0002405_respiratory_system_inflammati0.80817395
110MP0002928_abnormal_bile_duct0.79721248
111MP0000613_abnormal_salivary_gland0.79465673
112MP0002282_abnormal_trachea_morphology0.79141159
113MP0005025_abnormal_response_to0.78511270
114MP0003315_abnormal_perineum_morphology0.77880599
115MP0009785_altered_susceptibility_to0.77536103
116MP0000653_abnormal_sex_gland0.77121302
117MP0000477_abnormal_intestine_morphology0.76870309
118MP0003866_abnormal_defecation0.75043518
119MP0005171_absent_coat_pigmentation0.75036886
120MP0001119_abnormal_female_reproductive0.74605157
121MP0001873_stomach_inflammation0.74247525
122MP0005000_abnormal_immune_tolerance0.74074398
123MP0002751_abnormal_autonomic_nervous0.74039807
124MP0005410_abnormal_fertilization0.73528002
125MP0002161_abnormal_fertility/fecundity0.72825913
126MP0001529_abnormal_vocalization0.72815456
127MP0009278_abnormal_bone_marrow0.72548796
128MP0005408_hypopigmentation0.72317085
129MP0001270_distended_abdomen0.71840974
130MP0003938_abnormal_ear_development0.71386906
131MP0003699_abnormal_female_reproductive0.71192957
132MP0002111_abnormal_tail_morphology0.70781260
133MP0002938_white_spotting0.70752185
134MP0001485_abnormal_pinna_reflex0.70458380
135MP0003436_decreased_susceptibility_to0.70354178
136MP0008260_abnormal_autophagy0.69896566
137MP0003186_abnormal_redox_activity0.68833322
138MP0002009_preneoplasia0.68809068
139MP0000371_diluted_coat_color0.68550604
140MP0005384_cellular_phenotype0.68131231
141MP0005621_abnormal_cell_physiology0.67323593
142MP0008789_abnormal_olfactory_epithelium0.66598414
143MP0000358_abnormal_cell_content/0.66324682
144MP0002837_dystrophic_cardiac_calcinosis0.64800108
145MP0001186_pigmentation_phenotype0.64606193
146MP0005084_abnormal_gallbladder_morpholo0.63989736
147MP0005076_abnormal_cell_differentiation0.63979351
148MP0000537_abnormal_urethra_morphology0.63652646
149MP0004264_abnormal_extraembryonic_tissu0.63622004
150MP0006036_abnormal_mitochondrial_physio0.63287506
151MP0003656_abnormal_erythrocyte_physiolo0.61815188

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.95837413
2Reticulocytopenia (HP:0001896)4.57893178
3Abnormal number of erythroid precursors (HP:0012131)4.14962476
4Abnormality of cells of the erythroid lineage (HP:0012130)4.13249997
5Chromsome breakage (HP:0040012)3.95266203
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.75177202
7Abnormality of chromosome stability (HP:0003220)3.40555999
8Aplastic anemia (HP:0001915)3.35275633
9Thrombocytosis (HP:0001894)3.33917551
10Patellar aplasia (HP:0006443)3.32700872
11Oral leukoplakia (HP:0002745)3.24624649
12Abnormality of the preputium (HP:0100587)3.22757864
13Breast hypoplasia (HP:0003187)3.20765284
14Meckel diverticulum (HP:0002245)3.17251285
15Aplasia/Hypoplasia of the patella (HP:0006498)3.11391290
16Myelodysplasia (HP:0002863)3.06023001
17Abnormality of the ileum (HP:0001549)3.05511350
18Colon cancer (HP:0003003)3.03539067
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.00237496
20Pallor (HP:0000980)2.98535459
21Medulloblastoma (HP:0002885)2.93528115
22Small intestinal stenosis (HP:0012848)2.90687883
23Duodenal stenosis (HP:0100867)2.90687883
24Macrocytic anemia (HP:0001972)2.90096104
25Selective tooth agenesis (HP:0001592)2.86388237
26Bone marrow hypocellularity (HP:0005528)2.78699859
27Ependymoma (HP:0002888)2.77637611
28IgM deficiency (HP:0002850)2.73330983
29Hepatocellular necrosis (HP:0001404)2.72216085
30Abnormal mitochondria in muscle tissue (HP:0008316)2.71205841
31Aplasia/Hypoplasia of the sacrum (HP:0008517)2.65644668
32Abnormality of the heme biosynthetic pathway (HP:0010472)2.62993552
33Pancreatic cysts (HP:0001737)2.61248049
34Pendular nystagmus (HP:0012043)2.61192228
35Carpal bone hypoplasia (HP:0001498)2.61025390
36Pancreatic fibrosis (HP:0100732)2.60041698
3711 pairs of ribs (HP:0000878)2.59652400
38Absent thumb (HP:0009777)2.57108611
39Sloping forehead (HP:0000340)2.53914867
40Agnosia (HP:0010524)2.53792224
41Petechiae (HP:0000967)2.52599992
42Mitochondrial inheritance (HP:0001427)2.50593986
43Premature graying of hair (HP:0002216)2.48852069
44Short thumb (HP:0009778)2.47749407
45Neoplasm of the adrenal cortex (HP:0100641)2.47265118
46Abnormality of cochlea (HP:0000375)2.45937423
47Lymphoma (HP:0002665)2.44063512
48Increased CSF lactate (HP:0002490)2.41767941
49Acute necrotizing encephalopathy (HP:0006965)2.41393006
50Abnormality of the anterior horn cell (HP:0006802)2.39932698
51Degeneration of anterior horn cells (HP:0002398)2.39932698
52Rough bone trabeculation (HP:0100670)2.39239500
53Abnormality of the duodenum (HP:0002246)2.37857391
54Optic nerve coloboma (HP:0000588)2.35514360
55Hepatic necrosis (HP:0002605)2.35129195
56Impulsivity (HP:0100710)2.34715774
57Type I transferrin isoform profile (HP:0003642)2.34311629
58Rhabdomyosarcoma (HP:0002859)2.33543926
59Panhypogammaglobulinemia (HP:0003139)2.32934815
60True hermaphroditism (HP:0010459)2.32826333
61Ectopic kidney (HP:0000086)2.32577978
62Cerebral hypomyelination (HP:0006808)2.32118292
63Abnormal lung lobation (HP:0002101)2.29456274
64Hypoplasia of the pons (HP:0012110)2.25605493
65Clubbing of toes (HP:0100760)2.24764900
66Duplicated collecting system (HP:0000081)2.24329411
67Hypoplasia of the capital femoral epiphysis (HP:0003090)2.23619064
68Muscle fiber atrophy (HP:0100295)2.23468647
69Increased nuchal translucency (HP:0010880)2.22751256
70Abnormality of the carotid arteries (HP:0005344)2.22539889
71Sclerocornea (HP:0000647)2.21299033
72Microretrognathia (HP:0000308)2.20995042
73Abnormality of B cell number (HP:0010975)2.19257743
74B lymphocytopenia (HP:0010976)2.19257743
75Triphalangeal thumb (HP:0001199)2.16551830
76Increased serum lactate (HP:0002151)2.16479292
77Amaurosis fugax (HP:0100576)2.16184822
78Cellular immunodeficiency (HP:0005374)2.15944537
79Abnormal number of incisors (HP:0011064)2.15197766
80Pancytopenia (HP:0001876)2.14872308
81Abnormality of midbrain morphology (HP:0002418)2.13206372
82Molar tooth sign on MRI (HP:0002419)2.13206372
83Microvesicular hepatic steatosis (HP:0001414)2.12552220
84Abnormality of the pons (HP:0007361)2.11316049
85Tracheoesophageal fistula (HP:0002575)2.11276049
86Congenital stationary night blindness (HP:0007642)2.11259583
87Squamous cell carcinoma (HP:0002860)2.10608066
88High anterior hairline (HP:0009890)2.09721449
89Absent radius (HP:0003974)2.09567299
90Progressive macrocephaly (HP:0004481)2.09137680
91Acute encephalopathy (HP:0006846)2.08461765
92Morphological abnormality of the inner ear (HP:0011390)2.07890237
93Abnormality of the renal collecting system (HP:0004742)2.07514650
94Basal cell carcinoma (HP:0002671)2.07170595
95Tubulointerstitial nephritis (HP:0001970)2.06093290
96Neoplasm of the pancreas (HP:0002894)2.05014917
97Absent rod-and cone-mediated responses on ERG (HP:0007688)2.02564630
98Abnormality of DNA repair (HP:0003254)2.02539307
99Leukopenia (HP:0001882)2.01292418
100Type 2 muscle fiber atrophy (HP:0003554)1.98996703
101Prominent nose (HP:0000448)1.98476733
102Cafe-au-lait spot (HP:0000957)1.98167964
103Megaloblastic anemia (HP:0001889)1.97680960
104High pitched voice (HP:0001620)1.97128279
105Preaxial hand polydactyly (HP:0001177)1.96247718
106Abnormality of reticulocytes (HP:0004312)1.94762551
107Duplication of thumb phalanx (HP:0009942)1.93943202
108Nephronophthisis (HP:0000090)1.93149373
109Pulmonary fibrosis (HP:0002206)1.92899901
110Abnormal glycosylation (HP:0012345)1.92174467
111Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92174467
112Abnormal protein N-linked glycosylation (HP:0012347)1.92174467
113Abnormal protein glycosylation (HP:0012346)1.92174467
114Aplasia involving forearm bones (HP:0009822)1.91634478
115Absent forearm bone (HP:0003953)1.91634478
116Retinal dysplasia (HP:0007973)1.91275811
117Acute lymphatic leukemia (HP:0006721)1.91273702
118Type II lissencephaly (HP:0007260)1.87867261
119Granulocytopenia (HP:0001913)1.86233164
120Volvulus (HP:0002580)1.85425522
121Nephroblastoma (Wilms tumor) (HP:0002667)1.84249930
122Horseshoe kidney (HP:0000085)1.82667973
123Cystic liver disease (HP:0006706)1.82580295
124Methylmalonic aciduria (HP:0012120)1.81583259
125Aplasia/Hypoplasia of the thymus (HP:0010515)1.80652558
126Progressive microcephaly (HP:0000253)1.80407942
127Abnormality of the columella (HP:0009929)1.80349503
128Lipid accumulation in hepatocytes (HP:0006561)1.78998826
129Atresia of the external auditory canal (HP:0000413)1.77765472
130Poikiloderma (HP:0001029)1.77116429
131Chronic hepatic failure (HP:0100626)1.77030904
132Abnormality of the prostate (HP:0008775)1.77010689
133Elevated erythrocyte sedimentation rate (HP:0003565)1.76744423
134Abnormality of T cell physiology (HP:0011840)1.76293403
135Cleft eyelid (HP:0000625)1.76143811
136IgG deficiency (HP:0004315)1.76111935
137Agammaglobulinemia (HP:0004432)1.75819241
138Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.75483958
139Slender long bone (HP:0003100)1.74174078
140Abnormality of T cells (HP:0002843)1.73953463
141Broad distal phalanx of finger (HP:0009836)1.73247772
142Abnormality of the fingertips (HP:0001211)1.72855847
143Prolonged bleeding time (HP:0003010)1.72301125
144Abnormality of pyrimidine metabolism (HP:0004353)1.72167426
145Acute myeloid leukemia (HP:0004808)1.72126805
146Severe visual impairment (HP:0001141)1.72028262
147Oligohydramnios (HP:0001562)1.71209973
148Asplenia (HP:0001746)1.70924930
149Methylmalonic acidemia (HP:0002912)1.68754332
150Decreased activity of mitochondrial respiratory chain (HP:0008972)1.68305331
151Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.68305331
152Arteriovenous malformation (HP:0100026)1.67946148

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.99431462
2VRK24.51297961
3CDC74.47334903
4WEE14.26103472
5NEK22.87582169
6FRK2.69491165
7MKNK22.50967128
8MKNK12.48115808
9BRSK22.38431918
10PLK42.37778517
11STK162.33566457
12CCNB12.32465871
13TAF12.23268879
14NUAK12.23158731
15MAP4K22.21869978
16TTK2.18819255
17VRK12.11680901
18MAP4K12.10046689
19SRPK12.07611509
20TRIM282.04279937
21EIF2AK32.01983068
22BRSK11.99094556
23BMPR1B1.96010292
24EIF2AK11.92896221
25GRK11.92396393
26PLK11.86858140
27TLK11.83814296
28ATR1.82726118
29TSSK61.79859325
30SMG11.77535147
31NME21.73130695
32CDK71.71486304
33AURKB1.70822129
34BCKDK1.68991666
35PASK1.58897658
36CSNK1G31.57300156
37ACVR1B1.53710531
38TESK21.52193401
39TGFBR11.51958584
40NEK11.44717496
41CDK41.44341519
42CSNK1A1L1.44293626
43STK101.41977019
44CDK81.39818275
45CHEK21.38803589
46MARK31.35685839
47EEF2K1.33759686
48CSNK1G11.33163328
49RPS6KB21.30105426
50NME11.24929273
51FGFR21.23000594
52RPS6KA41.21856142
53AURKA1.20941657
54PINK11.20841436
55MAP3K101.20194988
56STK41.17300974
57DYRK31.16184393
58MAP3K81.13584317
59PLK31.13304602
60CLK11.04543052
61BTK1.02876054
62CHEK11.02703761
63CSNK1G21.01245357
64MAPKAPK50.99153222
65CDK90.95653637
66ZAK0.93568927
67KIT0.91829462
68KDR0.88178772
69LRRK20.85173439
70DYRK20.81479957
71PIM10.80275124
72TEC0.79273435
73ATM0.79221709
74BLK0.78189760
75BRAF0.76585699
76EIF2AK20.76069200
77MAP2K30.74726936
78CDK20.73340423
79MST40.72245102
80ZAP700.68732350
81IRAK40.67036443
82PIM20.65570593
83PAK40.65329824
84WNK30.64850631
85WNK40.59954690
86CSF1R0.59551296
87SCYL20.58791438
88CDK10.58056017
89MELK0.58025962
90CDK190.57823341
91ADRBK20.57256733
92SIK30.56952557
93CSNK2A10.56911027
94NEK90.54148971
95TRIB30.53101165
96TXK0.52927887
97BRD40.52662301
98CSNK2A20.52334250
99CDK30.51617565
100TNIK0.51254681
101SIK20.50935261
102PAK10.50239577
103CDK120.49731481
104CDK60.48159872
105MAPK110.46248270
106MAPK150.46184093
107RPS6KA50.45891191
108MAP2K20.45211214
109SYK0.43386038
110GRK60.42497270
111FLT30.42265276
112LYN0.39591168
113TGFBR20.38974684
114YES10.38052951
115ICK0.36055564
116CSNK1A10.35220252
117JAK30.32742711
118PRKCI0.31989067
119MATK0.31718921
120RPS6KA60.31703351
121MAPKAPK30.30744179
122TESK10.29685808
123AKT20.29545802
124MAP3K110.29248534
125TYK20.29122561
126INSRR0.28675299
127PNCK0.26231469
128EPHA20.26085600
129DAPK10.25809693
130RPS6KC10.25796048
131RPS6KL10.25796048
132HIPK20.25743681
133PRKDC0.23980017
134ITK0.23849771
135LCK0.22696822
136TBK10.21275998
137IKBKB0.20918648

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030306.00976931
2Mismatch repair_Homo sapiens_hsa034305.01819585
3Base excision repair_Homo sapiens_hsa034103.92862436
4Homologous recombination_Homo sapiens_hsa034403.56642147
5Ribosome_Homo sapiens_hsa030103.14820045
6Spliceosome_Homo sapiens_hsa030403.07836495
7Nucleotide excision repair_Homo sapiens_hsa034203.01699299
8Cell cycle_Homo sapiens_hsa041102.82658645
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.63755613
10Proteasome_Homo sapiens_hsa030502.56296269
11RNA transport_Homo sapiens_hsa030132.51010234
12One carbon pool by folate_Homo sapiens_hsa006702.48772857
13RNA polymerase_Homo sapiens_hsa030202.46135099
14Pyrimidine metabolism_Homo sapiens_hsa002402.44797526
15Fanconi anemia pathway_Homo sapiens_hsa034602.38531557
16Non-homologous end-joining_Homo sapiens_hsa034502.28002263
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.07628987
18p53 signaling pathway_Homo sapiens_hsa041151.65907036
19RNA degradation_Homo sapiens_hsa030181.63941581
20Basal transcription factors_Homo sapiens_hsa030221.52512318
21Phototransduction_Homo sapiens_hsa047441.37682144
22Oxidative phosphorylation_Homo sapiens_hsa001901.33657787
23Parkinsons disease_Homo sapiens_hsa050121.30524536
24mRNA surveillance pathway_Homo sapiens_hsa030151.29903804
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25764159
26Purine metabolism_Homo sapiens_hsa002301.22543558
27Systemic lupus erythematosus_Homo sapiens_hsa053221.21035331
28Primary immunodeficiency_Homo sapiens_hsa053401.17952097
29Epstein-Barr virus infection_Homo sapiens_hsa051691.08181100
30Folate biosynthesis_Homo sapiens_hsa007901.05465763
31Herpes simplex infection_Homo sapiens_hsa051681.03912458
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03749676
33Pentose phosphate pathway_Homo sapiens_hsa000300.97449052
34Drug metabolism - other enzymes_Homo sapiens_hsa009830.88423061
35Viral carcinogenesis_Homo sapiens_hsa052030.82725948
36Antigen processing and presentation_Homo sapiens_hsa046120.82605935
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79435386
38Maturity onset diabetes of the young_Homo sapiens_hsa049500.78610762
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77543670
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76433850
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.73857106
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72769441
43HTLV-I infection_Homo sapiens_hsa051660.72716694
44Selenocompound metabolism_Homo sapiens_hsa004500.72001759
45Oocyte meiosis_Homo sapiens_hsa041140.71537443
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.71446055
47Nitrogen metabolism_Homo sapiens_hsa009100.69241516
48Sulfur relay system_Homo sapiens_hsa041220.68655615
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67478329
50Small cell lung cancer_Homo sapiens_hsa052220.67308469
51Protein export_Homo sapiens_hsa030600.66683587
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66627533
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66386430
54Biosynthesis of amino acids_Homo sapiens_hsa012300.65682537
55Alzheimers disease_Homo sapiens_hsa050100.61205626
56Measles_Homo sapiens_hsa051620.60780881
57Asthma_Homo sapiens_hsa053100.60709196
58Fatty acid elongation_Homo sapiens_hsa000620.59761095
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58554165
60Hedgehog signaling pathway_Homo sapiens_hsa043400.58403943
61Glutathione metabolism_Homo sapiens_hsa004800.58182311
62Legionellosis_Homo sapiens_hsa051340.57333997
63N-Glycan biosynthesis_Homo sapiens_hsa005100.57064968
64Butanoate metabolism_Homo sapiens_hsa006500.56114379
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56095702
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.54335530
67Vitamin B6 metabolism_Homo sapiens_hsa007500.53724401
68Apoptosis_Homo sapiens_hsa042100.53408345
69Olfactory transduction_Homo sapiens_hsa047400.52105187
70Propanoate metabolism_Homo sapiens_hsa006400.51890575
71Basal cell carcinoma_Homo sapiens_hsa052170.51764598
72Hematopoietic cell lineage_Homo sapiens_hsa046400.51176408
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51035762
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50366334
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.48911158
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48736919
77Peroxisome_Homo sapiens_hsa041460.48524343
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47745536
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47028580
80Hepatitis B_Homo sapiens_hsa051610.46357401
81Pyruvate metabolism_Homo sapiens_hsa006200.46283600
82Fructose and mannose metabolism_Homo sapiens_hsa000510.44458941
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43556612
84Shigellosis_Homo sapiens_hsa051310.42418626
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40087638
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38183251
87MicroRNAs in cancer_Homo sapiens_hsa052060.37841731
88Melanoma_Homo sapiens_hsa052180.36054628
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35147046
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33992398
91Chronic myeloid leukemia_Homo sapiens_hsa052200.33891705
92Galactose metabolism_Homo sapiens_hsa000520.33118411
93B cell receptor signaling pathway_Homo sapiens_hsa046620.33084433
94Other glycan degradation_Homo sapiens_hsa005110.32649991
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31904256
96Carbon metabolism_Homo sapiens_hsa012000.31805433
97Thyroid cancer_Homo sapiens_hsa052160.31369269
98Leishmaniasis_Homo sapiens_hsa051400.30617467
99Alcoholism_Homo sapiens_hsa050340.30455946
100Influenza A_Homo sapiens_hsa051640.29684518
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29432424
102Notch signaling pathway_Homo sapiens_hsa043300.28129109
103Steroid biosynthesis_Homo sapiens_hsa001000.26496427
104Acute myeloid leukemia_Homo sapiens_hsa052210.23530145
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23219489
106Non-small cell lung cancer_Homo sapiens_hsa052230.22771117
107Regulation of autophagy_Homo sapiens_hsa041400.22043885
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21946012
109Colorectal cancer_Homo sapiens_hsa052100.21587363
110Metabolic pathways_Homo sapiens_hsa011000.20764302
111Lysine degradation_Homo sapiens_hsa003100.18259962
112Bladder cancer_Homo sapiens_hsa052190.18166988
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.17977481
114Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.16824597
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.16572688
116Renin-angiotensin system_Homo sapiens_hsa046140.16222557
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.15542021
118Pancreatic cancer_Homo sapiens_hsa052120.15515268
119Tryptophan metabolism_Homo sapiens_hsa003800.15197270
120Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.14106149
121Huntingtons disease_Homo sapiens_hsa050160.14050317
1222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.13804455
123HIF-1 signaling pathway_Homo sapiens_hsa040660.12933370
124Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.11972800
125Pathways in cancer_Homo sapiens_hsa052000.11683970
126Viral myocarditis_Homo sapiens_hsa054160.11633482
127Wnt signaling pathway_Homo sapiens_hsa043100.10954128
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.09973901
129T cell receptor signaling pathway_Homo sapiens_hsa046600.09270825
130Glycerolipid metabolism_Homo sapiens_hsa005610.08855387
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.07770076
132Type I diabetes mellitus_Homo sapiens_hsa049400.07282790
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.06237491
134Autoimmune thyroid disease_Homo sapiens_hsa053200.06203730
135beta-Alanine metabolism_Homo sapiens_hsa004100.04384729
136Chemical carcinogenesis_Homo sapiens_hsa052040.02979541
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.01707372

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