

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | nuclear pore complex assembly (GO:0051292) | 5.34940803 |
| 2 | protein localization to kinetochore (GO:0034501) | 5.34302798 |
| 3 | nuclear pore organization (GO:0006999) | 5.33659467 |
| 4 | mitotic metaphase plate congression (GO:0007080) | 5.25228828 |
| 5 | DNA replication initiation (GO:0006270) | 4.71745286 |
| 6 | protein localization to chromosome, centromeric region (GO:0071459) | 4.63046181 |
| 7 | metaphase plate congression (GO:0051310) | 4.59741082 |
| 8 | DNA unwinding involved in DNA replication (GO:0006268) | 4.53001086 |
| 9 | DNA replication checkpoint (GO:0000076) | 4.51966921 |
| 10 | mitotic nuclear envelope disassembly (GO:0007077) | 4.41555152 |
| 11 | regulation of spindle organization (GO:0090224) | 4.39257015 |
| 12 | kinetochore organization (GO:0051383) | 4.36451761 |
| 13 | mitotic chromosome condensation (GO:0007076) | 4.32172976 |
| 14 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.29471589 |
| 15 | positive regulation of chromosome segregation (GO:0051984) | 4.19180130 |
| 16 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 4.18167167 |
| 17 | DNA ligation (GO:0006266) | 4.16069697 |
| 18 | mitotic sister chromatid segregation (GO:0000070) | 4.15633832 |
| 19 | membrane disassembly (GO:0030397) | 4.13221003 |
| 20 | nuclear envelope disassembly (GO:0051081) | 4.13221003 |
| 21 | DNA replication-dependent nucleosome organization (GO:0034723) | 4.10942364 |
| 22 | DNA replication-dependent nucleosome assembly (GO:0006335) | 4.10942364 |
| 23 | CENP-A containing nucleosome assembly (GO:0034080) | 4.10781636 |
| 24 | pore complex assembly (GO:0046931) | 4.08774861 |
| 25 | DNA strand elongation (GO:0022616) | 4.08416999 |
| 26 | chromatin remodeling at centromere (GO:0031055) | 4.08340900 |
| 27 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 4.06565197 |
| 28 | sister chromatid segregation (GO:0000819) | 4.05231395 |
| 29 | attachment of spindle microtubules to kinetochore (GO:0008608) | 4.02554008 |
| 30 | establishment of integrated proviral latency (GO:0075713) | 4.00952933 |
| 31 | establishment of chromosome localization (GO:0051303) | 3.98069775 |
| 32 | mitotic sister chromatid cohesion (GO:0007064) | 3.97211301 |
| 33 | nucleobase biosynthetic process (GO:0046112) | 3.96452888 |
| 34 | mitotic recombination (GO:0006312) | 3.93775678 |
| 35 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.92873148 |
| 36 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.92127370 |
| 37 | non-recombinational repair (GO:0000726) | 3.92127370 |
| 38 | regulation of mitotic spindle organization (GO:0060236) | 3.91189343 |
| 39 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.90341267 |
| 40 | DNA replication-independent nucleosome organization (GO:0034724) | 3.90341267 |
| 41 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.87672654 |
| 42 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.87672654 |
| 43 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.87672654 |
| 44 | telomere maintenance via recombination (GO:0000722) | 3.86552220 |
| 45 | purine nucleobase biosynthetic process (GO:0009113) | 3.84992568 |
| 46 | kinetochore assembly (GO:0051382) | 3.78946047 |
| 47 | regulation of DNA endoreduplication (GO:0032875) | 3.70690603 |
| 48 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.69225058 |
| 49 | ribosome assembly (GO:0042255) | 3.68079015 |
| 50 | IMP biosynthetic process (GO:0006188) | 3.66703038 |
| 51 | histone exchange (GO:0043486) | 3.66153291 |
| 52 | meiotic chromosome segregation (GO:0045132) | 3.63388110 |
| 53 | regulation of chromosome segregation (GO:0051983) | 3.55119365 |
| 54 | spindle checkpoint (GO:0031577) | 3.53714997 |
| 55 | protein K6-linked ubiquitination (GO:0085020) | 3.51340265 |
| 56 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.50219176 |
| 57 | protein localization to chromosome (GO:0034502) | 3.49529753 |
| 58 | mitotic G2/M transition checkpoint (GO:0044818) | 3.49492940 |
| 59 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.46942878 |
| 60 | regulation of sister chromatid cohesion (GO:0007063) | 3.46121801 |
| 61 | DNA double-strand break processing (GO:0000729) | 3.44239018 |
| 62 | DNA duplex unwinding (GO:0032508) | 3.44032061 |
| 63 | DNA geometric change (GO:0032392) | 3.43662421 |
| 64 | DNA packaging (GO:0006323) | 3.40087634 |
| 65 | regulation of centrosome cycle (GO:0046605) | 3.39165823 |
| 66 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.38831719 |
| 67 | heterochromatin organization (GO:0070828) | 3.38568159 |
| 68 | L-serine metabolic process (GO:0006563) | 3.37548695 |
| 69 | chromatin assembly or disassembly (GO:0006333) | 3.37397632 |
| 70 | regulation of RNA export from nucleus (GO:0046831) | 3.36360421 |
| 71 | replication fork processing (GO:0031297) | 3.33793465 |
| 72 | regulation of centrosome duplication (GO:0010824) | 3.32175411 |
| 73 | chromosome segregation (GO:0007059) | 3.32000169 |
| 74 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.31551464 |
| 75 | telomere maintenance via telomere lengthening (GO:0010833) | 3.31040932 |
| 76 | formation of translation preinitiation complex (GO:0001731) | 3.30541083 |
| 77 | negative regulation of chromosome segregation (GO:0051985) | 3.29027413 |
| 78 | ribosome biogenesis (GO:0042254) | 3.28567344 |
| 79 | spindle assembly checkpoint (GO:0071173) | 3.27628622 |
| 80 | nuclear envelope organization (GO:0006998) | 3.24382182 |
| 81 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.24227922 |
| 82 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.24227922 |
| 83 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.24227922 |
| 84 | negative regulation of sister chromatid segregation (GO:0033046) | 3.24227922 |
| 85 | regulation of centriole replication (GO:0046599) | 3.24140662 |
| 86 | regulation of histone H3-K9 methylation (GO:0051570) | 3.24131575 |
| 87 | mitotic spindle checkpoint (GO:0071174) | 3.23912401 |
| 88 | regulation of sister chromatid segregation (GO:0033045) | 3.23886617 |
| 89 | regulation of mitotic sister chromatid separation (GO:0010965) | 3.23886617 |
| 90 | regulation of mitotic sister chromatid segregation (GO:0033047) | 3.23886617 |
| 91 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.23776487 |
| 92 | IMP metabolic process (GO:0046040) | 3.23040229 |
| 93 | mitotic spindle assembly checkpoint (GO:0007094) | 3.18119785 |
| 94 | protein complex localization (GO:0031503) | 3.17076514 |
| 95 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.14777582 |
| 96 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.14399215 |
| 97 | ATP-dependent chromatin remodeling (GO:0043044) | 3.13920934 |
| 98 | mitochondrial RNA metabolic process (GO:0000959) | 3.13857353 |
| 99 | microtubule depolymerization (GO:0007019) | 3.13362484 |
| 100 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.11581500 |
| 101 | regulation of helicase activity (GO:0051095) | 3.09978642 |
| 102 | negative regulation of DNA recombination (GO:0045910) | 3.08468483 |
| 103 | chromosome condensation (GO:0030261) | 3.05808485 |
| 104 | DNA conformation change (GO:0071103) | 3.05769703 |
| 105 | negative regulation of histone methylation (GO:0031061) | 3.05298034 |
| 106 | cellular protein complex localization (GO:0034629) | 3.03927600 |
| 107 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.03809575 |
| 108 | pre-miRNA processing (GO:0031054) | 3.03193256 |
| 109 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.02621382 |
| 110 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.02621382 |
| 111 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.01604654 |
| 112 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.01604654 |
| 113 | sister chromatid cohesion (GO:0007062) | 2.98260315 |
| 114 | translesion synthesis (GO:0019985) | 2.95447191 |
| 115 | dosage compensation (GO:0007549) | 2.93157011 |
| 116 | maturation of SSU-rRNA (GO:0030490) | 2.91290391 |
| 117 | telomere maintenance (GO:0000723) | 2.90262370 |
| 118 | telomere organization (GO:0032200) | 2.88649848 |
| 119 | inner cell mass cell proliferation (GO:0001833) | 2.88169642 |
| 120 | DNA topological change (GO:0006265) | 2.88165185 |
| 121 | postreplication repair (GO:0006301) | 2.87053900 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 5.56877067 |
| 2 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 4.49169415 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.77593385 |
| 4 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.64476529 |
| 5 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.82024663 |
| 6 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.80332040 |
| 7 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.74960662 |
| 8 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.63379464 |
| 9 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.58884959 |
| 10 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.56047772 |
| 11 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.42877473 |
| 12 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.40608666 |
| 13 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.38978037 |
| 14 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.36961861 |
| 15 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.34379473 |
| 16 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.30089506 |
| 17 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.27540693 |
| 18 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.09557311 |
| 19 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.07497545 |
| 20 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.07368033 |
| 21 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.05862576 |
| 22 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.01553025 |
| 23 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.00636812 |
| 24 | E2F7_22180533_ChIP-Seq_HELA_Human | 10.6942207 |
| 25 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.96769238 |
| 26 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.91829390 |
| 27 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.88390984 |
| 28 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.85848626 |
| 29 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.79005845 |
| 30 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.78331490 |
| 31 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.73475239 |
| 32 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.69592145 |
| 33 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.68746984 |
| 34 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.66265876 |
| 35 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.66201984 |
| 36 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.65026789 |
| 37 | FUS_26573619_Chip-Seq_HEK293_Human | 1.63812511 |
| 38 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.61478025 |
| 39 | MYC_22102868_ChIP-Seq_BL_Human | 1.61374697 |
| 40 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.60732725 |
| 41 | EWS_26573619_Chip-Seq_HEK293_Human | 1.58554530 |
| 42 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.55157047 |
| 43 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.53185232 |
| 44 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.50917883 |
| 45 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.49755174 |
| 46 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.47148552 |
| 47 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.46864047 |
| 48 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.45016899 |
| 49 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.44528022 |
| 50 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.42065775 |
| 51 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.41790148 |
| 52 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.40458763 |
| 53 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.40219543 |
| 54 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.38654314 |
| 55 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.37478972 |
| 56 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.35949783 |
| 57 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.31532933 |
| 58 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.29643046 |
| 59 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.25071499 |
| 60 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.23661509 |
| 61 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.23635913 |
| 62 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.22969027 |
| 63 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.22765027 |
| 64 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.21722649 |
| 65 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.21600561 |
| 66 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.18334539 |
| 67 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.15620189 |
| 68 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.15308389 |
| 69 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.15253385 |
| 70 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.14679562 |
| 71 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.13545188 |
| 72 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.11633493 |
| 73 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.10640416 |
| 74 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.08880437 |
| 75 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.07450489 |
| 76 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.04750312 |
| 77 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.03926056 |
| 78 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.01371349 |
| 79 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.00589187 |
| 80 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.00304602 |
| 81 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.97878039 |
| 82 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.97061631 |
| 83 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.95292275 |
| 84 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.94109775 |
| 85 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.92577628 |
| 86 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 0.92091724 |
| 87 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.91189964 |
| 88 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 0.90217389 |
| 89 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.89292413 |
| 90 | * CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.88580407 |
| 91 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.87879061 |
| 92 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.87879061 |
| 93 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.87879061 |
| 94 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.87460488 |
| 95 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.86943594 |
| 96 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.86828368 |
| 97 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.86072160 |
| 98 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.85039030 |
| 99 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.83919865 |
| 100 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.81978929 |
| 101 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.81295820 |
| 102 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 0.80229319 |
| 103 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.79094988 |
| 104 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.78464381 |
| 105 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.78348411 |
| 106 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.77936321 |
| 107 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.77694673 |
| 108 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.77308880 |
| 109 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 0.77212112 |
| 110 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.76105808 |
| 111 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.75723621 |
| 112 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.74888689 |
| 113 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.74555109 |
| 114 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.74460369 |
| 115 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.72330923 |
| 116 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.70039242 |
| 117 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.69738923 |
| 118 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.69701120 |
| 119 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.68753144 |
| 120 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 0.68346401 |
| 121 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.66225843 |
| 122 | P300_19829295_ChIP-Seq_ESCs_Human | 0.63701066 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 4.93013482 |
| 2 | MP0010094_abnormal_chromosome_stability | 4.69331752 |
| 3 | MP0008057_abnormal_DNA_replication | 4.56512387 |
| 4 | MP0003111_abnormal_nucleus_morphology | 4.41797092 |
| 5 | MP0004957_abnormal_blastocyst_morpholog | 4.01825832 |
| 6 | MP0003077_abnormal_cell_cycle | 3.96530740 |
| 7 | MP0008058_abnormal_DNA_repair | 3.13720445 |
| 8 | MP0008007_abnormal_cellular_replicative | 2.89745526 |
| 9 | MP0010307_abnormal_tumor_latency | 2.58139461 |
| 10 | MP0009697_abnormal_copulation | 2.56472844 |
| 11 | MP0008932_abnormal_embryonic_tissue | 2.52026354 |
| 12 | MP0003123_paternal_imprinting | 2.47517132 |
| 13 | MP0001730_embryonic_growth_arrest | 2.46960382 |
| 14 | MP0000350_abnormal_cell_proliferation | 2.41862775 |
| 15 | MP0010352_gastrointestinal_tract_polyps | 2.34985361 |
| 16 | MP0008877_abnormal_DNA_methylation | 2.32168038 |
| 17 | MP0002396_abnormal_hematopoietic_system | 2.22927674 |
| 18 | MP0005380_embryogenesis_phenotype | 1.99305758 |
| 19 | MP0001672_abnormal_embryogenesis/_devel | 1.99305758 |
| 20 | MP0001697_abnormal_embryo_size | 1.85540457 |
| 21 | MP0003984_embryonic_growth_retardation | 1.78240787 |
| 22 | MP0003786_premature_aging | 1.77303981 |
| 23 | MP0002088_abnormal_embryonic_growth/wei | 1.75146148 |
| 24 | MP0005076_abnormal_cell_differentiation | 1.73479520 |
| 25 | MP0002085_abnormal_embryonic_tissue | 1.70630801 |
| 26 | MP0002084_abnormal_developmental_patter | 1.70492811 |
| 27 | MP0004808_abnormal_hematopoietic_stem | 1.69923072 |
| 28 | MP0002086_abnormal_extraembryonic_tissu | 1.63645222 |
| 29 | MP0004197_abnormal_fetal_growth/weight/ | 1.63291561 |
| 30 | MP0002080_prenatal_lethality | 1.60189100 |
| 31 | MP0003718_maternal_effect | 1.60018768 |
| 32 | MP0003121_genomic_imprinting | 1.57789913 |
| 33 | MP0000490_abnormal_crypts_of | 1.55288815 |
| 34 | MP0002938_white_spotting | 1.48643152 |
| 35 | MP0003567_abnormal_fetal_cardiomyocyte | 1.45741529 |
| 36 | MP0001293_anophthalmia | 1.42741478 |
| 37 | MP0000313_abnormal_cell_death | 1.36136024 |
| 38 | MP0002019_abnormal_tumor_incidence | 1.33731919 |
| 39 | MP0010030_abnormal_orbit_morphology | 1.33260684 |
| 40 | MP0001661_extended_life_span | 1.32711631 |
| 41 | MP0003890_abnormal_embryonic-extraembry | 1.27198265 |
| 42 | MP0002210_abnormal_sex_determination | 1.26037887 |
| 43 | MP0001545_abnormal_hematopoietic_system | 1.25041123 |
| 44 | MP0005397_hematopoietic_system_phenotyp | 1.25041123 |
| 45 | MP0004185_abnormal_adipocyte_glucose | 1.21883707 |
| 46 | MP0009053_abnormal_anal_canal | 1.16957675 |
| 47 | MP0003937_abnormal_limbs/digits/tail_de | 1.15621526 |
| 48 | MP0003705_abnormal_hypodermis_morpholog | 1.13181875 |
| 49 | MP0001145_abnormal_male_reproductive | 1.09056795 |
| 50 | MP0002233_abnormal_nose_morphology | 1.06662438 |
| 51 | MP0006072_abnormal_retinal_apoptosis | 1.06606960 |
| 52 | MP0003941_abnormal_skin_development | 1.04834529 |
| 53 | MP0003315_abnormal_perineum_morphology | 1.03578385 |
| 54 | MP0008995_early_reproductive_senescence | 1.02952576 |
| 55 | MP0000703_abnormal_thymus_morphology | 1.00242186 |
| 56 | MP0001929_abnormal_gametogenesis | 0.99670234 |
| 57 | MP0009333_abnormal_splenocyte_physiolog | 0.99327002 |
| 58 | MP0009672_abnormal_birth_weight | 0.95938408 |
| 59 | MP0000653_abnormal_sex_gland | 0.95694997 |
| 60 | MP0009703_decreased_birth_body | 0.94704717 |
| 61 | MP0000647_abnormal_sebaceous_gland | 0.92151074 |
| 62 | MP0002234_abnormal_pharynx_morphology | 0.91604843 |
| 63 | MP0000537_abnormal_urethra_morphology | 0.90892827 |
| 64 | MP0003221_abnormal_cardiomyocyte_apopto | 0.90786858 |
| 65 | MP0002398_abnormal_bone_marrow | 0.90528515 |
| 66 | MP0003385_abnormal_body_wall | 0.89617503 |
| 67 | MP0002092_abnormal_eye_morphology | 0.88784356 |
| 68 | MP0000733_abnormal_muscle_development | 0.86878349 |
| 69 | MP0000428_abnormal_craniofacial_morphol | 0.86167975 |
| 70 | MP0001119_abnormal_female_reproductive | 0.85458258 |
| 71 | MP0005621_abnormal_cell_physiology | 0.83813785 |
| 72 | MP0001915_intracranial_hemorrhage | 0.83795222 |
| 73 | MP0000432_abnormal_head_morphology | 0.82910170 |
| 74 | MP0002722_abnormal_immune_system | 0.82906037 |
| 75 | MP0003136_yellow_coat_color | 0.82451651 |
| 76 | MP0005391_vision/eye_phenotype | 0.81944761 |
| 77 | MP0002111_abnormal_tail_morphology | 0.80301247 |
| 78 | MP0006292_abnormal_olfactory_placode | 0.80007491 |
| 79 | MP0005384_cellular_phenotype | 0.79748983 |
| 80 | MP0000579_abnormal_nail_morphology | 0.79627320 |
| 81 | MP0006035_abnormal_mitochondrial_morpho | 0.79459675 |
| 82 | MP0000689_abnormal_spleen_morphology | 0.79037323 |
| 83 | MP0000358_abnormal_cell_content/ | 0.77765068 |
| 84 | MP0001286_abnormal_eye_development | 0.77297315 |
| 85 | MP0005499_abnormal_olfactory_system | 0.76721735 |
| 86 | MP0005394_taste/olfaction_phenotype | 0.76721735 |
| 87 | MP0003119_abnormal_digestive_system | 0.76718720 |
| 88 | MP0005187_abnormal_penis_morphology | 0.76602721 |
| 89 | MP0003942_abnormal_urinary_system | 0.76375112 |
| 90 | MP0000569_abnormal_digit_pigmentation | 0.76157145 |
| 91 | MP0000049_abnormal_middle_ear | 0.76122403 |
| 92 | MP0003763_abnormal_thymus_physiology | 0.75375195 |
| 93 | MP0003566_abnormal_cell_adhesion | 0.74931259 |
| 94 | MP0003698_abnormal_male_reproductive | 0.74447261 |
| 95 | MP0003935_abnormal_craniofacial_develop | 0.72556704 |
| 96 | MP0008789_abnormal_olfactory_epithelium | 0.72164180 |
| 97 | MP0009278_abnormal_bone_marrow | 0.71383971 |
| 98 | MP0002877_abnormal_melanocyte_morpholog | 0.71301374 |
| 99 | MP0002160_abnormal_reproductive_system | 0.69733250 |
| 100 | MP0001177_atelectasis | 0.69728134 |
| 101 | MP0001188_hyperpigmentation | 0.68934150 |
| 102 | MP0000383_abnormal_hair_follicle | 0.68441856 |
| 103 | MP0005023_abnormal_wound_healing | 0.67881862 |
| 104 | MP0001849_ear_inflammation | 0.67332233 |
| 105 | MP0000631_abnormal_neuroendocrine_gland | 0.66796498 |
| 106 | MP0002081_perinatal_lethality | 0.66376452 |
| 107 | MP0002925_abnormal_cardiovascular_devel | 0.65418154 |
| 108 | MP0002006_tumorigenesis | 0.65267243 |
| 109 | MP0003755_abnormal_palate_morphology | 0.65144923 |
| 110 | MP0004264_abnormal_extraembryonic_tissu | 0.65059224 |
| 111 | MP0004233_abnormal_muscle_weight | 0.64767738 |
| 112 | MP0005623_abnormal_meninges_morphology | 0.64324022 |
| 113 | MP0005367_renal/urinary_system_phenotyp | 0.64322362 |
| 114 | MP0000516_abnormal_urinary_system | 0.64322362 |
| 115 | MP0005253_abnormal_eye_physiology | 0.64214035 |
| 116 | MP0006054_spinal_hemorrhage | 0.63786663 |
| 117 | MP0002697_abnormal_eye_size | 0.62541698 |
| 118 | MP0000627_abnormal_mammary_gland | 0.62184927 |
| 119 | MP0002161_abnormal_fertility/fecundity | 0.62178518 |
| 120 | MP0002751_abnormal_autonomic_nervous | 0.62098632 |
| 121 | MP0003448_altered_tumor_morphology | 0.62063096 |
| 122 | MP0002009_preneoplasia | 0.61715368 |
| 123 | MP0002429_abnormal_blood_cell | 0.61563011 |
| 124 | MP0003115_abnormal_respiratory_system | 0.59813279 |
| 125 | MP0000858_altered_metastatic_potential | 0.59204507 |
| 126 | MP0000477_abnormal_intestine_morphology | 0.58451683 |
| 127 | MP0010678_abnormal_skin_adnexa | 0.58400975 |
| 128 | MP0010234_abnormal_vibrissa_follicle | 0.57932510 |
| 129 | MP0002166_altered_tumor_susceptibility | 0.57884129 |
| 130 | MP0003699_abnormal_female_reproductive | 0.57526855 |
| 131 | MP0003787_abnormal_imprinting | 0.57145949 |
| 132 | MP0005389_reproductive_system_phenotype | 0.56882123 |
| 133 | MP0003861_abnormal_nervous_system | 0.55864169 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 5.23431385 |
| 2 | Chromsome breakage (HP:0040012) | 4.39675965 |
| 3 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 4.12111864 |
| 4 | Breast hypoplasia (HP:0003187) | 3.85085282 |
| 5 | Impulsivity (HP:0100710) | 3.62415181 |
| 6 | Abnormality of chromosome stability (HP:0003220) | 3.57397190 |
| 7 | Patellar aplasia (HP:0006443) | 3.54497028 |
| 8 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.35089139 |
| 9 | Meckel diverticulum (HP:0002245) | 3.27081937 |
| 10 | Abnormality of the labia minora (HP:0012880) | 3.17058052 |
| 11 | Abnormality of the preputium (HP:0100587) | 3.12158889 |
| 12 | Selective tooth agenesis (HP:0001592) | 3.11455747 |
| 13 | Abnormality of the ileum (HP:0001549) | 3.08627121 |
| 14 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.04693858 |
| 15 | Ependymoma (HP:0002888) | 3.04117512 |
| 16 | Medulloblastoma (HP:0002885) | 3.01880960 |
| 17 | Cortical dysplasia (HP:0002539) | 2.90189897 |
| 18 | Colon cancer (HP:0003003) | 2.87520672 |
| 19 | Ectopic kidney (HP:0000086) | 2.82569631 |
| 20 | Absent radius (HP:0003974) | 2.74681542 |
| 21 | Small intestinal stenosis (HP:0012848) | 2.74364268 |
| 22 | Duodenal stenosis (HP:0100867) | 2.74364268 |
| 23 | Reticulocytopenia (HP:0001896) | 2.73779884 |
| 24 | Volvulus (HP:0002580) | 2.70131284 |
| 25 | Rhabdomyosarcoma (HP:0002859) | 2.69966029 |
| 26 | Myelodysplasia (HP:0002863) | 2.69719498 |
| 27 | Facial hemangioma (HP:0000329) | 2.62877769 |
| 28 | Deviation of the thumb (HP:0009603) | 2.62073640 |
| 29 | Carpal bone hypoplasia (HP:0001498) | 2.61511757 |
| 30 | Proximal placement of thumb (HP:0009623) | 2.60595824 |
| 31 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.59838518 |
| 32 | Abnormality of alanine metabolism (HP:0010916) | 2.59838518 |
| 33 | Hyperalaninemia (HP:0003348) | 2.59838518 |
| 34 | Absent forearm bone (HP:0003953) | 2.55066358 |
| 35 | Aplasia involving forearm bones (HP:0009822) | 2.55066358 |
| 36 | Increased nuchal translucency (HP:0010880) | 2.46233160 |
| 37 | Abnormality of the anterior horn cell (HP:0006802) | 2.45476132 |
| 38 | Degeneration of anterior horn cells (HP:0002398) | 2.45476132 |
| 39 | Prominent nose (HP:0000448) | 2.45373918 |
| 40 | Oral leukoplakia (HP:0002745) | 2.41187742 |
| 41 | Agnosia (HP:0010524) | 2.38460086 |
| 42 | Atresia of the external auditory canal (HP:0000413) | 2.37706914 |
| 43 | Absent thumb (HP:0009777) | 2.35591493 |
| 44 | Arteriovenous malformation (HP:0100026) | 2.35441192 |
| 45 | Sloping forehead (HP:0000340) | 2.34040761 |
| 46 | Short 4th metacarpal (HP:0010044) | 2.33418408 |
| 47 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.33418408 |
| 48 | Abnormality of the duodenum (HP:0002246) | 2.26341103 |
| 49 | Neoplasm of the pancreas (HP:0002894) | 2.25255687 |
| 50 | Astrocytoma (HP:0009592) | 2.23979325 |
| 51 | Abnormality of the astrocytes (HP:0100707) | 2.23979325 |
| 52 | Cafe-au-lait spot (HP:0000957) | 2.23317891 |
| 53 | Abnormal number of incisors (HP:0011064) | 2.22581414 |
| 54 | Rough bone trabeculation (HP:0100670) | 2.22511220 |
| 55 | Abnormality of the carotid arteries (HP:0005344) | 2.21659144 |
| 56 | Basal cell carcinoma (HP:0002671) | 2.21194231 |
| 57 | Short thumb (HP:0009778) | 2.16879125 |
| 58 | Bone marrow hypocellularity (HP:0005528) | 2.16722991 |
| 59 | Squamous cell carcinoma (HP:0002860) | 2.14051388 |
| 60 | Abnormality of the fetal cardiovascular system (HP:0010948) | 2.13935112 |
| 61 | Abnormal umbilical cord blood vessels (HP:0011403) | 2.13935112 |
| 62 | Single umbilical artery (HP:0001195) | 2.13935112 |
| 63 | Embryonal neoplasm (HP:0002898) | 2.13923276 |
| 64 | Supernumerary spleens (HP:0009799) | 2.13707011 |
| 65 | Premature graying of hair (HP:0002216) | 2.12100188 |
| 66 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.11168336 |
| 67 | Abnormal lung lobation (HP:0002101) | 2.11007700 |
| 68 | Glioma (HP:0009733) | 2.10263093 |
| 69 | Tracheoesophageal fistula (HP:0002575) | 2.09681084 |
| 70 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.08787596 |
| 71 | Hepatoblastoma (HP:0002884) | 2.03545511 |
| 72 | Neoplasm of the colon (HP:0100273) | 1.99555626 |
| 73 | Intestinal atresia (HP:0011100) | 1.99097352 |
| 74 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.99041613 |
| 75 | Embryonal renal neoplasm (HP:0011794) | 1.98750880 |
| 76 | Multiple enchondromatosis (HP:0005701) | 1.98733139 |
| 77 | High pitched voice (HP:0001620) | 1.98359391 |
| 78 | Abnormality of homocysteine metabolism (HP:0010919) | 1.97930196 |
| 79 | Homocystinuria (HP:0002156) | 1.97930196 |
| 80 | Aplasia/hypoplasia of the humerus (HP:0006507) | 1.97813161 |
| 81 | Abnormality of the fingertips (HP:0001211) | 1.96688686 |
| 82 | Long eyelashes (HP:0000527) | 1.96271140 |
| 83 | Horseshoe kidney (HP:0000085) | 1.95765404 |
| 84 | Neoplasm of striated muscle (HP:0009728) | 1.95545126 |
| 85 | Sparse lateral eyebrow (HP:0005338) | 1.94998509 |
| 86 | Neoplasm of the oral cavity (HP:0100649) | 1.94794517 |
| 87 | Acute myeloid leukemia (HP:0004808) | 1.93606044 |
| 88 | Amaurosis fugax (HP:0100576) | 1.92426937 |
| 89 | Abnormal number of erythroid precursors (HP:0012131) | 1.92392052 |
| 90 | Clubbing of toes (HP:0100760) | 1.92351100 |
| 91 | Biliary tract neoplasm (HP:0100574) | 1.91035557 |
| 92 | Cutaneous melanoma (HP:0012056) | 1.90361598 |
| 93 | Slender long bone (HP:0003100) | 1.89232567 |
| 94 | Triphalangeal thumb (HP:0001199) | 1.88980951 |
| 95 | Microtia (HP:0008551) | 1.88461135 |
| 96 | Neoplasm of the adrenal cortex (HP:0100641) | 1.88337444 |
| 97 | Breast aplasia (HP:0100783) | 1.87912414 |
| 98 | Entropion (HP:0000621) | 1.87305953 |
| 99 | Abnormality of serum amino acid levels (HP:0003112) | 1.86916273 |
| 100 | Aplastic anemia (HP:0001915) | 1.86529927 |
| 101 | Deep philtrum (HP:0002002) | 1.85263319 |
| 102 | Oligodactyly (HP:0012165) | 1.84795419 |
| 103 | Abnormality of cochlea (HP:0000375) | 1.84743115 |
| 104 | Leiomyosarcoma (HP:0100243) | 1.83791466 |
| 105 | Uterine leiomyosarcoma (HP:0002891) | 1.83791466 |
| 106 | 11 pairs of ribs (HP:0000878) | 1.83602881 |
| 107 | Pelvic girdle muscle weakness (HP:0003749) | 1.83391430 |
| 108 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.82463105 |
| 109 | Abnormality of DNA repair (HP:0003254) | 1.81258802 |
| 110 | Esophageal atresia (HP:0002032) | 1.80711859 |
| 111 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.79880905 |
| 112 | Duplicated collecting system (HP:0000081) | 1.78345805 |
| 113 | Sandal gap (HP:0001852) | 1.77462940 |
| 114 | Overlapping toe (HP:0001845) | 1.76536412 |
| 115 | Abnormality of methionine metabolism (HP:0010901) | 1.75942725 |
| 116 | Aplasia/Hypoplasia of the breasts (HP:0010311) | 1.75663119 |
| 117 | Short humerus (HP:0005792) | 1.74467861 |
| 118 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 1.74069525 |
| 119 | Gastrointestinal atresia (HP:0002589) | 1.73304717 |
| 120 | Duplication of thumb phalanx (HP:0009942) | 1.72842356 |
| 121 | Transitional cell carcinoma of the bladder (HP:0006740) | 1.71524759 |
| 122 | Facial cleft (HP:0002006) | 1.71461095 |
| 123 | Ankle contracture (HP:0006466) | 1.71238501 |
| 124 | Progressive external ophthalmoplegia (HP:0000590) | 1.70918586 |
| 125 | Cellular immunodeficiency (HP:0005374) | 1.70251371 |
| 126 | Abnormality of chromosome segregation (HP:0002916) | 1.69710599 |
| 127 | Choanal atresia (HP:0000453) | 1.69106319 |
| 128 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.68965891 |
| 129 | Gastrointestinal carcinoma (HP:0002672) | 1.68965891 |
| 130 | Abnormal trabecular bone morphology (HP:0100671) | 1.67551574 |
| 131 | High anterior hairline (HP:0009890) | 1.66850736 |
| 132 | Microvesicular hepatic steatosis (HP:0001414) | 1.66765176 |
| 133 | Missing ribs (HP:0000921) | 1.66264765 |
| 134 | Short middle phalanx of the 5th finger (HP:0004220) | 1.64133719 |
| 135 | Oligodactyly (hands) (HP:0001180) | 1.63785021 |
| 136 | Hereditary nonpolyposis colorectal carcinoma (HP:0006716) | 1.63155615 |
| 137 | Abnormality of the umbilical cord (HP:0010881) | 1.61659899 |
| 138 | Small hand (HP:0200055) | 1.61279443 |
| 139 | Diastasis recti (HP:0001540) | 1.59822531 |
| 140 | Uterine neoplasm (HP:0010784) | 1.59574910 |
| 141 | Abnormality of the septum pellucidum (HP:0007375) | 1.59155551 |
| 142 | Stenosis of the external auditory canal (HP:0000402) | 1.58657329 |
| 143 | Ovarian neoplasm (HP:0100615) | 1.57169494 |
| 144 | Bladder carcinoma (HP:0002862) | 1.55222634 |
| 145 | Bladder neoplasm (HP:0009725) | 1.55222634 |
| 146 | Intestinal polyposis (HP:0200008) | 1.52642131 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDC7 | 4.86202613 |
| 2 | WEE1 | 4.19409239 |
| 3 | BUB1 | 3.69876357 |
| 4 | NEK2 | 3.48641828 |
| 5 | CDK12 | 3.02337419 |
| 6 | SRPK1 | 2.63162577 |
| 7 | PBK | 2.62398264 |
| 8 | EIF2AK1 | 2.62193777 |
| 9 | TTK | 2.61209153 |
| 10 | NEK1 | 2.50191344 |
| 11 | BRSK2 | 2.47600663 |
| 12 | MKNK1 | 2.42993852 |
| 13 | PLK4 | 2.25850151 |
| 14 | MKNK2 | 2.22227844 |
| 15 | PLK1 | 2.17948927 |
| 16 | ACVR1B | 2.07014684 |
| 17 | PLK3 | 1.97304205 |
| 18 | TSSK6 | 1.89382305 |
| 19 | AURKB | 1.88233106 |
| 20 | TAF1 | 1.85519125 |
| 21 | ATR | 1.83798377 |
| 22 | CHEK2 | 1.80240504 |
| 23 | CDK7 | 1.69586531 |
| 24 | RPS6KA4 | 1.62286928 |
| 25 | CDK4 | 1.61758986 |
| 26 | EIF2AK3 | 1.61729735 |
| 27 | CHEK1 | 1.49202448 |
| 28 | TLK1 | 1.45516574 |
| 29 | STK3 | 1.44699731 |
| 30 | DYRK3 | 1.43659191 |
| 31 | VRK1 | 1.42432051 |
| 32 | RPS6KB2 | 1.38690291 |
| 33 | MAP3K8 | 1.36832005 |
| 34 | BRSK1 | 1.35291657 |
| 35 | STK10 | 1.33817788 |
| 36 | TRIM28 | 1.33782580 |
| 37 | LATS1 | 1.32890198 |
| 38 | CDK6 | 1.28466648 |
| 39 | PASK | 1.27448407 |
| 40 | STK4 | 1.27273569 |
| 41 | EEF2K | 1.25038076 |
| 42 | ZAK | 1.23861757 |
| 43 | TESK2 | 1.20161999 |
| 44 | ATM | 1.18166608 |
| 45 | TNIK | 1.13397918 |
| 46 | ERBB3 | 1.12901502 |
| 47 | VRK2 | 1.10427414 |
| 48 | BCR | 1.09625290 |
| 49 | PIM1 | 1.09162021 |
| 50 | ALK | 1.07694151 |
| 51 | BRD4 | 1.03984377 |
| 52 | CDK2 | 1.03959020 |
| 53 | BMPR1B | 0.99851867 |
| 54 | AURKA | 0.97610633 |
| 55 | NME2 | 0.97580365 |
| 56 | PLK2 | 0.96672361 |
| 57 | MST4 | 0.95031203 |
| 58 | MELK | 0.90762197 |
| 59 | EPHA2 | 0.89298344 |
| 60 | CCNB1 | 0.88138328 |
| 61 | SCYL2 | 0.83664431 |
| 62 | LATS2 | 0.81963886 |
| 63 | CDK1 | 0.81415843 |
| 64 | WNK3 | 0.77432750 |
| 65 | TGFBR1 | 0.76309117 |
| 66 | CAMK1G | 0.75965311 |
| 67 | ERBB4 | 0.75915340 |
| 68 | PAK4 | 0.72484721 |
| 69 | STK38L | 0.71824284 |
| 70 | EIF2AK2 | 0.69926264 |
| 71 | MTOR | 0.69100088 |
| 72 | PKN2 | 0.65690923 |
| 73 | MAP3K10 | 0.62448564 |
| 74 | CSNK1G1 | 0.62372719 |
| 75 | MARK3 | 0.59206054 |
| 76 | CSNK2A2 | 0.58353730 |
| 77 | NEK9 | 0.56812778 |
| 78 | RPS6KA5 | 0.53403334 |
| 79 | CSNK2A1 | 0.51465266 |
| 80 | PAK1 | 0.48378342 |
| 81 | FLT3 | 0.47969624 |
| 82 | PNCK | 0.47891618 |
| 83 | CDK8 | 0.47535834 |
| 84 | SMG1 | 0.47351875 |
| 85 | CSNK1D | 0.41760954 |
| 86 | CSNK1E | 0.41357265 |
| 87 | MAP3K4 | 0.40315478 |
| 88 | PRKDC | 0.40271647 |
| 89 | MAPK14 | 0.40155267 |
| 90 | PDK2 | 0.38879094 |
| 91 | CSNK1A1L | 0.38770837 |
| 92 | STK16 | 0.38603886 |
| 93 | CSNK1G3 | 0.36863985 |
| 94 | AKT3 | 0.36687228 |
| 95 | PAK2 | 0.36490968 |
| 96 | LRRK2 | 0.36472799 |
| 97 | NUAK1 | 0.36353030 |
| 98 | STK39 | 0.35623650 |
| 99 | TTN | 0.35573306 |
| 100 | PRKCI | 0.35280537 |
| 101 | FGFR1 | 0.35124539 |
| 102 | CDK3 | 0.35095336 |
| 103 | CLK1 | 0.34539744 |
| 104 | RPS6KB1 | 0.33826552 |
| 105 | MAP4K1 | 0.32265456 |
| 106 | NLK | 0.32165821 |
| 107 | YES1 | 0.31785026 |
| 108 | AKT2 | 0.28363784 |
| 109 | MAPK1 | 0.28349188 |
| 110 | CSNK1G2 | 0.28150034 |
| 111 | CDK19 | 0.27045648 |
| 112 | AKT1 | 0.26869147 |
| 113 | MAP4K2 | 0.26738426 |
| 114 | NEK6 | 0.26474840 |
| 115 | BRAF | 0.26208064 |
| 116 | CDK9 | 0.26205216 |
| 117 | GSK3B | 0.25023933 |
| 118 | FRK | 0.24114050 |
| 119 | TEC | 0.24018326 |
| 120 | CAMK1D | 0.23848719 |
| 121 | CHUK | 0.21500880 |
| 122 | JAK3 | 0.20525560 |
| 123 | STK24 | 0.18877318 |
| 124 | CSF1R | 0.17882608 |
| 125 | MAPK10 | 0.15595321 |
| 126 | TESK1 | 0.14911665 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.72718953 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 4.06766008 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.80975021 |
| 4 | RNA transport_Homo sapiens_hsa03013 | 3.40367686 |
| 5 | Cell cycle_Homo sapiens_hsa04110 | 3.39994417 |
| 6 | Spliceosome_Homo sapiens_hsa03040 | 3.19989707 |
| 7 | Homologous recombination_Homo sapiens_hsa03440 | 3.11205559 |
| 8 | RNA polymerase_Homo sapiens_hsa03020 | 2.84069985 |
| 9 | Base excision repair_Homo sapiens_hsa03410 | 2.80247101 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.79804578 |
| 11 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.66302997 |
| 12 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.63120891 |
| 13 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.24042485 |
| 14 | Basal transcription factors_Homo sapiens_hsa03022 | 2.16797573 |
| 15 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.09966128 |
| 16 | p53 signaling pathway_Homo sapiens_hsa04115 | 2.07111965 |
| 17 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.06498488 |
| 18 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.05675088 |
| 19 | RNA degradation_Homo sapiens_hsa03018 | 1.98567299 |
| 20 | Ribosome_Homo sapiens_hsa03010 | 1.91904068 |
| 21 | Proteasome_Homo sapiens_hsa03050 | 1.77786310 |
| 22 | Protein export_Homo sapiens_hsa03060 | 1.59971708 |
| 23 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.50590901 |
| 24 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.50375258 |
| 25 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.36834193 |
| 26 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.30019394 |
| 27 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.29920416 |
| 28 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.27635936 |
| 29 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.26644183 |
| 30 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.23357136 |
| 31 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.17935466 |
| 32 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.16031421 |
| 33 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.15378882 |
| 34 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.13416477 |
| 35 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.13051831 |
| 36 | Purine metabolism_Homo sapiens_hsa00230 | 1.08401844 |
| 37 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.06330857 |
| 38 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.02255099 |
| 39 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.99633041 |
| 40 | HTLV-I infection_Homo sapiens_hsa05166 | 0.96789225 |
| 41 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.92877616 |
| 42 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.91052539 |
| 43 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.85125765 |
| 44 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.84718718 |
| 45 | Thyroid cancer_Homo sapiens_hsa05216 | 0.83941792 |
| 46 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.81491727 |
| 47 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.80027944 |
| 48 | Carbon metabolism_Homo sapiens_hsa01200 | 0.77321790 |
| 49 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.73056039 |
| 50 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.71358024 |
| 51 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.70859039 |
| 52 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.69203301 |
| 53 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.68135986 |
| 54 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.65371665 |
| 55 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.61912362 |
| 56 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.61579405 |
| 57 | Hepatitis B_Homo sapiens_hsa05161 | 0.60952518 |
| 58 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.60140088 |
| 59 | Colorectal cancer_Homo sapiens_hsa05210 | 0.59903082 |
| 60 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.59638656 |
| 61 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.55612255 |
| 62 | Measles_Homo sapiens_hsa05162 | 0.54422090 |
| 63 | Alcoholism_Homo sapiens_hsa05034 | 0.54177242 |
| 64 | Apoptosis_Homo sapiens_hsa04210 | 0.53150140 |
| 65 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.52496880 |
| 66 | Adherens junction_Homo sapiens_hsa04520 | 0.52305393 |
| 67 | Prostate cancer_Homo sapiens_hsa05215 | 0.51691482 |
| 68 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.50982074 |
| 69 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.50136547 |
| 70 | Legionellosis_Homo sapiens_hsa05134 | 0.49842324 |
| 71 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.49164042 |
| 72 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.46628316 |
| 73 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.44287942 |
| 74 | Influenza A_Homo sapiens_hsa05164 | 0.44169502 |
| 75 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.43934447 |
| 76 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.41873205 |
| 77 | Pathways in cancer_Homo sapiens_hsa05200 | 0.41446416 |
| 78 | Shigellosis_Homo sapiens_hsa05131 | 0.41327382 |
| 79 | Viral myocarditis_Homo sapiens_hsa05416 | 0.40932602 |
| 80 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.40686717 |
| 81 | Lysine degradation_Homo sapiens_hsa00310 | 0.40098491 |
| 82 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.39971623 |
| 83 | Bladder cancer_Homo sapiens_hsa05219 | 0.39787879 |
| 84 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.39398745 |
| 85 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.38994925 |
| 86 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.38648917 |
| 87 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.37735900 |
| 88 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.37364029 |
| 89 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.36400022 |
| 90 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.33821427 |
| 91 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.33675415 |
| 92 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.32885815 |
| 93 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.32309063 |
| 94 | Endometrial cancer_Homo sapiens_hsa05213 | 0.32004100 |
| 95 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.31918363 |
| 96 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.31274856 |
| 97 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.29287887 |
| 98 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.28246098 |
| 99 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.28121293 |
| 100 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.28097547 |
| 101 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.28007274 |
| 102 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.26605301 |
| 103 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.26172087 |
| 104 | Melanoma_Homo sapiens_hsa05218 | 0.26015724 |
| 105 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.25896764 |
| 106 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.25822567 |
| 107 | Metabolic pathways_Homo sapiens_hsa01100 | 0.25697394 |
| 108 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.24658354 |
| 109 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.23983628 |
| 110 | Tight junction_Homo sapiens_hsa04530 | 0.23943229 |
| 111 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.21827357 |
| 112 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.21285562 |
| 113 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.21206816 |
| 114 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.21062872 |
| 115 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.21001356 |
| 116 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.20627968 |
| 117 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.20532843 |
| 118 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.20482247 |
| 119 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.16910352 |
| 120 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.16839871 |
| 121 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.16698592 |
| 122 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.16618122 |
| 123 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.16195338 |
| 124 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.15313553 |
| 125 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.15272579 |
| 126 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.15039300 |
| 127 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.14855678 |
| 128 | Sulfur relay system_Homo sapiens_hsa04122 | 0.13227025 |
| 129 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.11695404 |
| 130 | Glioma_Homo sapiens_hsa05214 | 0.08971826 |
| 131 | Huntingtons disease_Homo sapiens_hsa05016 | 0.08441997 |
| 132 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.07636074 |

