HAUS6P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)5.37677378
2DNA double-strand break processing (GO:0000729)5.37500602
3negative regulation of DNA-dependent DNA replication (GO:2000104)5.28182467
4CENP-A containing nucleosome assembly (GO:0034080)5.04878417
5DNA replication checkpoint (GO:0000076)4.75266583
6replication fork processing (GO:0031297)4.45697924
7histone exchange (GO:0043486)4.45695211
8protein localization to kinetochore (GO:0034501)4.22499070
9regulation of nuclear cell cycle DNA replication (GO:0033262)4.02026327
10cullin deneddylation (GO:0010388)3.95572959
11proteasome assembly (GO:0043248)3.88595649
12DNA replication-independent nucleosome organization (GO:0034724)3.85857562
13DNA replication-independent nucleosome assembly (GO:0006336)3.85857562
14DNA catabolic process, exonucleolytic (GO:0000738)3.75168961
15maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.75153334
16regulation of DNA endoreduplication (GO:0032875)3.68999607
17DNA damage response, detection of DNA damage (GO:0042769)3.66500328
18peptidyl-histidine modification (GO:0018202)3.64012663
19protein deneddylation (GO:0000338)3.63654955
20DNA replication-dependent nucleosome assembly (GO:0006335)3.59523827
21DNA replication-dependent nucleosome organization (GO:0034723)3.59523827
22exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.53315099
23DNA ligation (GO:0006266)3.50853863
24nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.39901688
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.35827505
26NADH dehydrogenase complex assembly (GO:0010257)3.35827505
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35827505
28centriole replication (GO:0007099)3.35453895
29mitochondrial respiratory chain complex assembly (GO:0033108)3.33329888
30postreplication repair (GO:0006301)3.31168427
31kinetochore organization (GO:0051383)3.29966785
32protein complex biogenesis (GO:0070271)3.28284434
33mitotic metaphase plate congression (GO:0007080)3.27027049
34protein neddylation (GO:0045116)3.26360165
35kinetochore assembly (GO:0051382)3.19466242
36respiratory chain complex IV assembly (GO:0008535)3.19219219
37establishment of protein localization to mitochondrial membrane (GO:0090151)3.18881251
38regulation of centriole replication (GO:0046599)3.18433451
39platelet dense granule organization (GO:0060155)3.15097761
40protein localization to cilium (GO:0061512)3.14267698
41purine nucleobase biosynthetic process (GO:0009113)3.10457933
42spindle checkpoint (GO:0031577)3.08269586
43metaphase plate congression (GO:0051310)3.06734275
44recombinational repair (GO:0000725)3.05648034
45double-strand break repair via homologous recombination (GO:0000724)3.05392157
46protein K6-linked ubiquitination (GO:0085020)3.04970016
47organelle disassembly (GO:1903008)3.03518407
48nucleobase biosynthetic process (GO:0046112)2.99873849
49regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.96254973
50rRNA modification (GO:0000154)2.95278921
51negative regulation of telomere maintenance (GO:0032205)2.94336141
52intraciliary transport (GO:0042073)2.93043341
53telomere maintenance via telomerase (GO:0007004)2.92802420
54regulation of meiosis I (GO:0060631)2.92617203
55behavioral response to nicotine (GO:0035095)2.92405375
56transcription from mitochondrial promoter (GO:0006390)2.91697828
57mitotic spindle checkpoint (GO:0071174)2.89019592
58negative regulation of mitotic sister chromatid separation (GO:2000816)2.87882594
59negative regulation of sister chromatid segregation (GO:0033046)2.87882594
60negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.87882594
61negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.87882594
62negative regulation of mitotic sister chromatid segregation (GO:0033048)2.87882594
63water-soluble vitamin biosynthetic process (GO:0042364)2.87872010
64protein localization to chromosome, centromeric region (GO:0071459)2.87793704
65negative regulation of chromosome segregation (GO:0051985)2.86906884
66negative regulation of DNA recombination (GO:0045910)2.86811193
67mitotic G2/M transition checkpoint (GO:0044818)2.86422863
68negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.86396405
69histone mRNA metabolic process (GO:0008334)2.86230735
70mitochondrial RNA metabolic process (GO:0000959)2.85414926
71somite rostral/caudal axis specification (GO:0032525)2.84906744
72regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.84261832
73regulation of mitotic metaphase/anaphase transition (GO:0030071)2.84261832
74IMP biosynthetic process (GO:0006188)2.83991058
75telomere maintenance via semi-conservative replication (GO:0032201)2.83932274
76attachment of spindle microtubules to kinetochore (GO:0008608)2.83789418
77RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.83651239
78transcription elongation from RNA polymerase I promoter (GO:0006362)2.83511358
79spindle assembly checkpoint (GO:0071173)2.81427486
80DNA strand renaturation (GO:0000733)2.80269325
81rRNA methylation (GO:0031167)2.80210018
82microtubule polymerization or depolymerization (GO:0031109)2.79811339
83cytochrome complex assembly (GO:0017004)2.78416472
84anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.76723227
85transcription elongation from RNA polymerase III promoter (GO:0006385)2.76282762
86termination of RNA polymerase III transcription (GO:0006386)2.76282762
87establishment of integrated proviral latency (GO:0075713)2.74012737
88centrosome organization (GO:0051297)2.72839791
89sister chromatid segregation (GO:0000819)2.72653823
90positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.71797568
91resolution of meiotic recombination intermediates (GO:0000712)2.71569275
92histone H2A acetylation (GO:0043968)2.70307463
93regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.69109045
94regulation of double-strand break repair via homologous recombination (GO:0010569)2.68917014
95telomere maintenance via telomere lengthening (GO:0010833)2.67776741
96regulation of mitotic spindle checkpoint (GO:1903504)2.67338389
97regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.67338389
98somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.67250077
99somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.67250077
100isotype switching (GO:0045190)2.67250077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.25704327
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.55193647
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.34773809
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.21912453
5ZNF274_21170338_ChIP-Seq_K562_Hela3.01527135
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.78716437
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.77905955
8E2F7_22180533_ChIP-Seq_HELA_Human2.72123149
9VDR_22108803_ChIP-Seq_LS180_Human2.69076914
10ELK1_19687146_ChIP-ChIP_HELA_Human2.49674895
11EWS_26573619_Chip-Seq_HEK293_Human2.45266767
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.43517470
13FUS_26573619_Chip-Seq_HEK293_Human2.29722982
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.28740506
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.20585998
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18249746
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17925599
18VDR_23849224_ChIP-Seq_CD4+_Human2.08510030
19IGF1R_20145208_ChIP-Seq_DFB_Human2.05173381
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.04449017
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.01705306
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98752107
23FOXM1_23109430_ChIP-Seq_U2OS_Human1.93168706
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.92581517
25POU5F1_16153702_ChIP-ChIP_HESCs_Human1.91353578
26TAF15_26573619_Chip-Seq_HEK293_Human1.91340949
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89754195
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86518520
29P300_19829295_ChIP-Seq_ESCs_Human1.84622971
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81912323
31FOXP3_21729870_ChIP-Seq_TREG_Human1.81191307
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.73381024
33MYC_18940864_ChIP-ChIP_HL60_Human1.73362619
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72825612
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.72687478
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71073065
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68748090
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.64479540
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.55423510
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55402256
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54590265
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48408263
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42723389
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.39091699
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38417355
46DCP1A_22483619_ChIP-Seq_HELA_Human1.37441679
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35029821
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34185033
49AR_21909140_ChIP-Seq_LNCAP_Human1.33049383
50NANOG_16153702_ChIP-ChIP_HESCs_Human1.31289310
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29979261
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28401709
53NANOG_19829295_ChIP-Seq_ESCs_Human1.26686132
54SOX2_19829295_ChIP-Seq_ESCs_Human1.26686132
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24635576
56GBX2_23144817_ChIP-Seq_PC3_Human1.23705805
57GABP_19822575_ChIP-Seq_HepG2_Human1.23463668
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23078712
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21655406
60BCAT_22108803_ChIP-Seq_LS180_Human1.21418920
61RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21144346
62IRF1_19129219_ChIP-ChIP_H3396_Human1.20171016
63SOX2_16153702_ChIP-ChIP_HESCs_Human1.19773422
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19033011
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.18690245
66TTF2_22483619_ChIP-Seq_HELA_Human1.17977613
67ER_23166858_ChIP-Seq_MCF-7_Human1.16394617
68CBP_20019798_ChIP-Seq_JUKART_Human1.16088228
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16088228
70FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15410838
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.15090378
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15002665
73MYCN_18555785_ChIP-Seq_MESCs_Mouse1.14726675
74E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12843282
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12381979
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12268202
77AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10251067
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09989481
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09121184
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09121184
81MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09097382
82HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08499667
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08347774
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07951949
85TP53_22573176_ChIP-Seq_HFKS_Human1.07202079
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.07155146
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07155146
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06977083
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05313474
90NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04834469
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04551404
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.04464126
93TCF4_22108803_ChIP-Seq_LS180_Human1.03084235
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02957027
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02725338
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01222639
97MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00751461
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.00443041
99SMAD4_21741376_ChIP-Seq_EPCs_Human0.98656972
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97907437

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001529_abnormal_vocalization3.15210042
2MP0006292_abnormal_olfactory_placode3.13401428
3MP0010094_abnormal_chromosome_stability3.08678360
4MP0009697_abnormal_copulation2.96997452
5MP0003195_calcinosis2.89247520
6MP0002102_abnormal_ear_morphology2.81187431
7MP0008058_abnormal_DNA_repair2.57710819
8MP0006072_abnormal_retinal_apoptosis2.38876675
9MP0008877_abnormal_DNA_methylation2.36835735
10MP0003693_abnormal_embryo_hatching2.36478747
11MP0003890_abnormal_embryonic-extraembry2.35494967
12MP0001984_abnormal_olfaction2.33194103
13MP0001188_hyperpigmentation2.15495564
14MP0006054_spinal_hemorrhage2.15292790
15MP0008057_abnormal_DNA_replication2.14464137
16MP0004957_abnormal_blastocyst_morpholog2.08650524
17MP0002254_reproductive_system_inflammat2.04418112
18MP0002938_white_spotting2.03160732
19MP0003111_abnormal_nucleus_morphology1.93246848
20MP0003786_premature_aging1.90887476
21MP0001293_anophthalmia1.88678239
22MP0008932_abnormal_embryonic_tissue1.81120677
23MP0003077_abnormal_cell_cycle1.74447434
24MP0002751_abnormal_autonomic_nervous1.72386382
25MP0008789_abnormal_olfactory_epithelium1.69980083
26MP0008007_abnormal_cellular_replicative1.68901224
27MP0004133_heterotaxia1.68143342
28MP0005394_taste/olfaction_phenotype1.66939053
29MP0005499_abnormal_olfactory_system1.66939053
30MP0002090_abnormal_vision1.64943071
31MP0003119_abnormal_digestive_system1.64474539
32MP0003121_genomic_imprinting1.62267643
33MP0003718_maternal_effect1.57393632
34MP0005253_abnormal_eye_physiology1.55930821
35MP0003806_abnormal_nucleotide_metabolis1.53955346
36MP0005187_abnormal_penis_morphology1.50674105
37MP0005367_renal/urinary_system_phenotyp1.46686088
38MP0000516_abnormal_urinary_system1.46686088
39MP0001485_abnormal_pinna_reflex1.44099222
40MP0004885_abnormal_endolymph1.42306487
41MP0003567_abnormal_fetal_cardiomyocyte1.39563411
42MP0003880_abnormal_central_pattern1.39208616
43MP0003937_abnormal_limbs/digits/tail_de1.37843391
44MP0006035_abnormal_mitochondrial_morpho1.36514409
45MP0003787_abnormal_imprinting1.35708892
46MP0000631_abnormal_neuroendocrine_gland1.35325430
47MP0006036_abnormal_mitochondrial_physio1.32450956
48MP0002163_abnormal_gland_morphology1.28485228
49MP0003941_abnormal_skin_development1.28433902
50MP0005551_abnormal_eye_electrophysiolog1.27666018
51MP0002736_abnormal_nociception_after1.26632097
52MP0000647_abnormal_sebaceous_gland1.25304271
53MP0000049_abnormal_middle_ear1.21099981
54MP0004215_abnormal_myocardial_fiber1.19109564
55MP0002653_abnormal_ependyma_morphology1.13368766
56MP0001929_abnormal_gametogenesis1.08775743
57MP0000372_irregular_coat_pigmentation1.08529349
58MP0003136_yellow_coat_color1.08467625
59MP0003123_paternal_imprinting1.08163128
60MP0008872_abnormal_physiological_respon1.07193289
61MP0004043_abnormal_pH_regulation1.05845444
62MP0002234_abnormal_pharynx_morphology1.05499994
63MP0003011_delayed_dark_adaptation1.04698240
64MP0002210_abnormal_sex_determination1.04542077
65MP0003122_maternal_imprinting1.03325263
66MP0002160_abnormal_reproductive_system1.00178599
67MP0001764_abnormal_homeostasis0.98518455
68MP0002837_dystrophic_cardiac_calcinosis0.96990663
69MP0003137_abnormal_impulse_conducting0.96796777
70MP0004142_abnormal_muscle_tone0.96219684
71MP0008995_early_reproductive_senescence0.95824379
72MP0000653_abnormal_sex_gland0.94878524
73MP0001286_abnormal_eye_development0.94643852
74MP0005379_endocrine/exocrine_gland_phen0.94006181
75MP0005391_vision/eye_phenotype0.92675154
76MP0009745_abnormal_behavioral_response0.91982768
77MP0001968_abnormal_touch/_nociception0.90557384
78MP0004147_increased_porphyrin_level0.90548638
79MP0005389_reproductive_system_phenotype0.90070428
80MP0004145_abnormal_muscle_electrophysio0.87838569
81MP0001119_abnormal_female_reproductive0.86935176
82MP0002638_abnormal_pupillary_reflex0.86412751
83MP0003698_abnormal_male_reproductive0.85158309
84MP0001145_abnormal_male_reproductive0.84620367
85MP0003186_abnormal_redox_activity0.83890357
86MP0005645_abnormal_hypothalamus_physiol0.81809488
87MP0002084_abnormal_developmental_patter0.81679815
88MP0003221_abnormal_cardiomyocyte_apopto0.80071970
89MP0004085_abnormal_heartbeat0.78960851
90MP0000427_abnormal_hair_cycle0.78581638
91MP0001486_abnormal_startle_reflex0.78152461
92MP0001177_atelectasis0.78151348
93MP0002085_abnormal_embryonic_tissue0.75721368
94MP0010030_abnormal_orbit_morphology0.74993091
95MP0009046_muscle_twitch0.70698966
96MP0005195_abnormal_posterior_eye0.69798249
97MP0002282_abnormal_trachea_morphology0.68957022
98MP0002111_abnormal_tail_morphology0.68767817
99MP0005380_embryogenesis_phenotype0.68707264
100MP0001672_abnormal_embryogenesis/_devel0.68707264

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the uvula (HP:0010293)3.39846107
2Meckel diverticulum (HP:0002245)3.33532331
3Abnormality of the labia minora (HP:0012880)3.32236452
4Abnormality of the ileum (HP:0001549)3.15676698
5Pancreatic cysts (HP:0001737)3.11156229
6Abnormality of chromosome stability (HP:0003220)3.08396631
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.04102761
8True hermaphroditism (HP:0010459)2.99567232
9Hyperinsulinemic hypoglycemia (HP:0000825)2.98173316
10Increased serum pyruvate (HP:0003542)2.97458613
11Molar tooth sign on MRI (HP:0002419)2.89565276
12Abnormality of midbrain morphology (HP:0002418)2.89565276
13Nephronophthisis (HP:0000090)2.83184123
14Chromsome breakage (HP:0040012)2.82905124
15Abnormality of the preputium (HP:0100587)2.82161977
16Pancreatic fibrosis (HP:0100732)2.81759607
17Abnormality of glycolysis (HP:0004366)2.67231197
18Acute necrotizing encephalopathy (HP:0006965)2.65131585
19Small intestinal stenosis (HP:0012848)2.50498026
20Duodenal stenosis (HP:0100867)2.50498026
21Abnormal lung lobation (HP:0002101)2.48896522
22Acute encephalopathy (HP:0006846)2.48399763
23Abnormality of the duodenum (HP:0002246)2.44676549
24Progressive macrocephaly (HP:0004481)2.41947077
25Progressive inability to walk (HP:0002505)2.40406155
26Hypoglycemic seizures (HP:0002173)2.36020944
27Methylmalonic acidemia (HP:0002912)2.35780986
28Triphalangeal thumb (HP:0001199)2.33586198
29Colon cancer (HP:0003003)2.32885135
30Clubbing of toes (HP:0100760)2.32772252
31Increased CSF lactate (HP:0002490)2.32671990
32Abnormality of alanine metabolism (HP:0010916)2.32601225
33Hyperalaninemia (HP:0003348)2.32601225
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32601225
35Volvulus (HP:0002580)2.32331607
36Prominent metopic ridge (HP:0005487)2.28097028
37Septo-optic dysplasia (HP:0100842)2.24855419
38Mitochondrial inheritance (HP:0001427)2.24678176
39Abnormality of the metopic suture (HP:0005556)2.23269759
403-Methylglutaconic aciduria (HP:0003535)2.20666684
41Intestinal atresia (HP:0011100)2.19369820
42Abnormality of the renal medulla (HP:0100957)2.19031742
43Congenital, generalized hypertrichosis (HP:0004540)2.18732239
44Hepatocellular necrosis (HP:0001404)2.18316525
45Abnormal mitochondria in muscle tissue (HP:0008316)2.16334910
46Inability to walk (HP:0002540)2.16056091
47Postaxial foot polydactyly (HP:0001830)2.13663197
48Increased serum lactate (HP:0002151)2.11813159
49Sloping forehead (HP:0000340)2.10487282
50Increased hepatocellular lipid droplets (HP:0006565)2.09276951
51Aplasia/Hypoplasia of the tongue (HP:0010295)2.08363854
52Adrenal hypoplasia (HP:0000835)2.07817360
53Median cleft lip (HP:0000161)2.07673111
54Hepatic necrosis (HP:0002605)2.07269141
55Abnormality of the renal cortex (HP:0011035)2.07246892
56Supernumerary spleens (HP:0009799)2.03921614
57Hypoglycemic coma (HP:0001325)2.03500262
58Medial flaring of the eyebrow (HP:0010747)2.03237476
59Birth length less than 3rd percentile (HP:0003561)2.02083736
60Abolished electroretinogram (ERG) (HP:0000550)2.00795027
61Absent/shortened dynein arms (HP:0200106)2.00574403
62Dynein arm defect of respiratory motile cilia (HP:0012255)2.00574403
63Lipid accumulation in hepatocytes (HP:0006561)2.00102825
64Abnormality of serum amino acid levels (HP:0003112)1.99598302
65Abnormal respiratory motile cilium morphology (HP:0005938)1.95567832
66Abnormal respiratory epithelium morphology (HP:0012253)1.95567832
67Bile duct proliferation (HP:0001408)1.93687930
68Abnormal biliary tract physiology (HP:0012439)1.93687930
69Hyperglycinemia (HP:0002154)1.93021775
70Male pseudohermaphroditism (HP:0000037)1.87288690
71Disproportionate short-trunk short stature (HP:0003521)1.84354889
72Hypothermia (HP:0002045)1.82668860
73Anencephaly (HP:0002323)1.81181883
74Dandy-Walker malformation (HP:0001305)1.79324298
75Renal cortical cysts (HP:0000803)1.78866375
76Sclerocornea (HP:0000647)1.78786240
77Abnormality of the carotid arteries (HP:0005344)1.78654036
78Absent septum pellucidum (HP:0001331)1.78265221
79Cerebral edema (HP:0002181)1.77524019
80Type 2 muscle fiber atrophy (HP:0003554)1.75895335
81Methylmalonic aciduria (HP:0012120)1.75349768
82Short tibia (HP:0005736)1.74232897
83Abnormal respiratory motile cilium physiology (HP:0012261)1.73706890
84Abnormality of aspartate family amino acid metabolism (HP:0010899)1.73645748
85Cystic liver disease (HP:0006706)1.72958084
86Poor suck (HP:0002033)1.72827416
87Hypomagnesemia (HP:0002917)1.72534217
88Aplasia/Hypoplasia of the tibia (HP:0005772)1.71975885
89Abnormal ciliary motility (HP:0012262)1.71793889
90Genital tract atresia (HP:0001827)1.71701700
91Anophthalmia (HP:0000528)1.69715722
92Oligodactyly (hands) (HP:0001180)1.67730671
93Myelodysplasia (HP:0002863)1.66993879
94Embryonal renal neoplasm (HP:0011794)1.66384395
95Preaxial hand polydactyly (HP:0001177)1.66107323
96Neoplasm of the adrenal gland (HP:0100631)1.65943024
97Cortical dysplasia (HP:0002539)1.65729639
98Aqueductal stenosis (HP:0002410)1.65549563
99Oligohydramnios (HP:0001562)1.65420173
100Abnormality of the anterior horn cell (HP:0006802)1.64988457

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.69190803
2NUAK13.26310062
3TRIM283.16703319
4PLK42.95859254
5TSSK62.91343355
6BUB12.84381674
7WNK32.68877181
8CDC72.51180549
9MKNK22.44553389
10WEE12.35918435
11ZAK2.27769466
12LATS12.25592855
13FRK2.23775255
14BMPR1B2.23630982
15NEK12.20815907
16MST42.19629239
17TTK2.14032209
18ERBB32.07630208
19PLK32.03923537
20SRPK11.99704031
21ACVR1B1.92931559
22BCR1.92153507
23TNIK1.88150049
24EIF2AK31.83496472
25EIF2AK11.83213564
26MKNK11.83084983
27PLK21.79247376
28INSRR1.65662337
29ADRBK21.64430706
30VRK21.55824553
31BRSK21.52690687
32DYRK31.34397111
33PLK11.30905047
34AKT31.26123559
35VRK11.25305826
36CSNK1G11.15364567
37CSNK1G31.14408284
38CSNK1G21.10924035
39PBK1.10483645
40PNCK1.05134113
41STK161.01094868
42MAP3K41.00333301
43GRK10.96447125
44STK30.95562907
45MAPK130.91199843
46TAF10.90648884
47OXSR10.88168486
48BRAF0.85563753
49CSNK1A1L0.85072258
50CDK190.84216525
51WNK40.82646163
52EIF2AK20.78691159
53ATR0.77911866
54BRSK10.77621273
55SIK30.75875214
56PINK10.73688184
57DYRK20.73029567
58BCKDK0.70950495
59STK390.69262365
60MUSK0.68283906
61TGFBR10.63585719
62RPS6KA40.59255596
63PRKCG0.55567663
64TLK10.52938490
65AURKB0.51558276
66PKN10.51379243
67NLK0.49807302
68ATM0.47544998
69MAP2K70.47350378
70FGFR10.46412199
71CASK0.45527759
72FLT30.45125490
73EPHA40.44370419
74DAPK20.44069121
75PRKCE0.43503441
76PASK0.42380725
77IRAK10.42042209
78CHEK20.41587312
79CDK30.39688504
80NEK20.36681388
81CHEK10.36269703
82CSNK2A10.34904547
83FGFR20.34258389
84CCNB10.32939933
85PRKD30.32492001
86LIMK10.31427226
87STK38L0.29839759
88NEK90.29344070
89ADRBK10.29278825
90MINK10.29156221
91MAPKAPK50.28938246
92ERBB40.28752190
93CSNK1A10.26609534
94CSNK1E0.26110723
95STK100.25848854
96CSNK2A20.25241807
97FER0.24119671
98RPS6KA50.21024289
99PAK30.20569602
100NME20.20290204

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.60478766
2Proteasome_Homo sapiens_hsa030503.11087557
3Homologous recombination_Homo sapiens_hsa034402.77573859
4Mismatch repair_Homo sapiens_hsa034302.71199081
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.58544408
6Non-homologous end-joining_Homo sapiens_hsa034502.49403574
7DNA replication_Homo sapiens_hsa030302.43186941
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.42837442
9Fanconi anemia pathway_Homo sapiens_hsa034602.33818575
10RNA polymerase_Homo sapiens_hsa030202.21461692
11Propanoate metabolism_Homo sapiens_hsa006402.20726008
12Basal transcription factors_Homo sapiens_hsa030222.17371084
13Oxidative phosphorylation_Homo sapiens_hsa001902.07022877
14RNA degradation_Homo sapiens_hsa030181.99533826
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.87862445
16Fatty acid elongation_Homo sapiens_hsa000621.80922469
17Steroid biosynthesis_Homo sapiens_hsa001001.78863345
18Nucleotide excision repair_Homo sapiens_hsa034201.77947812
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77065292
20Butanoate metabolism_Homo sapiens_hsa006501.76950816
21Vitamin B6 metabolism_Homo sapiens_hsa007501.75967894
22Parkinsons disease_Homo sapiens_hsa050121.74928141
23One carbon pool by folate_Homo sapiens_hsa006701.70541526
24RNA transport_Homo sapiens_hsa030131.61918461
25Cell cycle_Homo sapiens_hsa041101.60286169
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59454464
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59034218
28Spliceosome_Homo sapiens_hsa030401.49390822
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.48717763
30Base excision repair_Homo sapiens_hsa034101.39208692
31Phototransduction_Homo sapiens_hsa047441.36638158
32Huntingtons disease_Homo sapiens_hsa050161.31895682
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.31417541
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31400275
35Pyruvate metabolism_Homo sapiens_hsa006201.29571744
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28702843
37Selenocompound metabolism_Homo sapiens_hsa004501.26111405
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23898438
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19871140
40Pyrimidine metabolism_Homo sapiens_hsa002401.18361128
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.16869364
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11033469
43Oocyte meiosis_Homo sapiens_hsa041141.08778033
44Purine metabolism_Homo sapiens_hsa002301.03297420
45Alzheimers disease_Homo sapiens_hsa050100.99268357
46Caffeine metabolism_Homo sapiens_hsa002320.99123071
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97899943
48Regulation of autophagy_Homo sapiens_hsa041400.97240239
49Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93197853
50Peroxisome_Homo sapiens_hsa041460.91683361
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89037332
52Linoleic acid metabolism_Homo sapiens_hsa005910.86831136
53Ether lipid metabolism_Homo sapiens_hsa005650.83151311
54Fatty acid degradation_Homo sapiens_hsa000710.82432384
55p53 signaling pathway_Homo sapiens_hsa041150.81997891
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80940848
57beta-Alanine metabolism_Homo sapiens_hsa004100.80939451
58Nitrogen metabolism_Homo sapiens_hsa009100.80322732
59Tryptophan metabolism_Homo sapiens_hsa003800.80217011
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77953046
61Nicotine addiction_Homo sapiens_hsa050330.75141486
62Retinol metabolism_Homo sapiens_hsa008300.72067218
63Ribosome_Homo sapiens_hsa030100.71026769
64Fat digestion and absorption_Homo sapiens_hsa049750.70848746
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70705431
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70403508
67Fatty acid metabolism_Homo sapiens_hsa012120.70093014
68mRNA surveillance pathway_Homo sapiens_hsa030150.70018949
69Vitamin digestion and absorption_Homo sapiens_hsa049770.68031678
70Metabolic pathways_Homo sapiens_hsa011000.67361554
71Chemical carcinogenesis_Homo sapiens_hsa052040.66803535
72Glutathione metabolism_Homo sapiens_hsa004800.66249684
73Hedgehog signaling pathway_Homo sapiens_hsa043400.66206231
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64594541
75Folate biosynthesis_Homo sapiens_hsa007900.62342483
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61853041
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58180342
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57249658
79Collecting duct acid secretion_Homo sapiens_hsa049660.56940127
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.55608040
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54993811
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53537418
83Olfactory transduction_Homo sapiens_hsa047400.53427530
84TGF-beta signaling pathway_Homo sapiens_hsa043500.51117964
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.50856080
86Cardiac muscle contraction_Homo sapiens_hsa042600.48393006
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47419400
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.46797531
89Carbon metabolism_Homo sapiens_hsa012000.44608961
90Basal cell carcinoma_Homo sapiens_hsa052170.43638811
91Wnt signaling pathway_Homo sapiens_hsa043100.43527879
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42661711
93Arginine and proline metabolism_Homo sapiens_hsa003300.41549994
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40073134
95Sulfur metabolism_Homo sapiens_hsa009200.37186892
96Arachidonic acid metabolism_Homo sapiens_hsa005900.34736852
97Hippo signaling pathway_Homo sapiens_hsa043900.32658859
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31540613
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.30548111
100Glycerolipid metabolism_Homo sapiens_hsa005610.28590493

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