HAUS6P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NIK/NF-kappaB signaling (GO:0038061)8.43220070
2urinary tract smooth muscle contraction (GO:0014848)6.96465199
3behavioral response to nicotine (GO:0035095)6.84053889
4cytoplasmic mRNA processing body assembly (GO:0033962)6.24611190
5response to pheromone (GO:0019236)6.24023995
6pharyngeal system development (GO:0060037)6.04531881
7regulation of gene silencing by RNA (GO:0060966)5.20245180
8regulation of posttranscriptional gene silencing (GO:0060147)5.20245180
9regulation of gene silencing by miRNA (GO:0060964)5.20245180
10spinal cord association neuron differentiation (GO:0021527)5.09907123
11necroptotic process (GO:0070266)5.08605031
12positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)5.04800061
13regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)5.04800061
14tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.96135257
15RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.96135257
16phosphatidylinositol acyl-chain remodeling (GO:0036149)4.63153992
17cerebellar Purkinje cell differentiation (GO:0021702)4.62925498
18regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)4.59916797
19positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO4.59916797
20DNA deamination (GO:0045006)4.57957684
21phosphatidylserine acyl-chain remodeling (GO:0036150)4.43538155
22purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)4.40127707
23lymph node development (GO:0048535)4.31671263
24gamma-aminobutyric acid signaling pathway (GO:0007214)4.30533841
25regulation of action potential (GO:0098900)4.24306368
26kynurenine metabolic process (GO:0070189)4.20709746
27postsynaptic membrane organization (GO:0001941)4.19737206
28peristalsis (GO:0030432)4.17576059
29negative regulation of nitric-oxide synthase activity (GO:0051001)4.15277093
30aggressive behavior (GO:0002118)4.10380547
31cell proliferation in forebrain (GO:0021846)4.09026816
32histone H4-K12 acetylation (GO:0043983)4.07679512
33positive regulation of action potential (GO:0045760)4.06998856
34regulation of T cell mediated cytotoxicity (GO:0001914)4.03336159
35behavioral response to pain (GO:0048266)4.01766058
36indole-containing compound catabolic process (GO:0042436)3.98954212
37indolalkylamine catabolic process (GO:0046218)3.98954212
38tryptophan catabolic process (GO:0006569)3.98954212
39serotonin metabolic process (GO:0042428)3.77606026
40regulation of cellular extravasation (GO:0002691)3.75548499
41activated T cell proliferation (GO:0050798)3.74745594
42GMP metabolic process (GO:0046037)3.73341107
43interkinetic nuclear migration (GO:0022027)3.69762046
44embryonic skeletal joint morphogenesis (GO:0060272)3.61950170
45positive regulation of mRNA catabolic process (GO:0061014)3.60115039
46tachykinin receptor signaling pathway (GO:0007217)3.59468760
47positive regulation of mRNA 3-end processing (GO:0031442)3.56199699
48opioid receptor signaling pathway (GO:0038003)3.54328572
49positive regulation of uterine smooth muscle contraction (GO:0070474)3.50629265
50tryptophan metabolic process (GO:0006568)3.42386833
51negative regulation by host of viral transcription (GO:0043922)3.38135339
52regulation of rhodopsin mediated signaling pathway (GO:0022400)3.37813349
53T cell homeostasis (GO:0043029)3.36870875
54signal peptide processing (GO:0006465)3.35349493
55oogenesis (GO:0048477)3.35251005
56positive regulation of synaptic transmission, GABAergic (GO:0032230)3.34063152
57forebrain neuron differentiation (GO:0021879)3.33806606
58cornea development in camera-type eye (GO:0061303)3.33594542
59spleen development (GO:0048536)3.32932768
60regulation of short-term neuronal synaptic plasticity (GO:0048172)3.31031072
61programmed necrotic cell death (GO:0097300)3.27730600
62necrotic cell death (GO:0070265)3.27613315
63regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.26097101
64negative regulation of monooxygenase activity (GO:0032769)3.23929733
65indole-containing compound metabolic process (GO:0042430)3.23054665
66phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.19619532
67regulation of germinal center formation (GO:0002634)3.19246857
68piRNA metabolic process (GO:0034587)3.18348815
69DNA methylation involved in gamete generation (GO:0043046)3.12375767
70seminiferous tubule development (GO:0072520)3.12039273
71negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.11076362
72negative regulation of translation, ncRNA-mediated (GO:0040033)3.11076362
73regulation of translation, ncRNA-mediated (GO:0045974)3.11076362
74regulation of female gonad development (GO:2000194)3.09463027
75positive regulation by host of viral transcription (GO:0043923)3.09054174
76primary amino compound metabolic process (GO:1901160)3.08332392
77neuronal action potential (GO:0019228)3.05179782
78rhodopsin mediated signaling pathway (GO:0016056)3.01641765
79drinking behavior (GO:0042756)3.00369587
80sodium-independent organic anion transport (GO:0043252)2.92512864
81positive regulation of renal sodium excretion (GO:0035815)2.89260201
82regulation of necroptotic process (GO:0060544)2.89084431
83regulation of mRNA catabolic process (GO:0061013)2.88180053
84regulation of double-strand break repair via homologous recombination (GO:0010569)2.85296222
85regulation of uterine smooth muscle contraction (GO:0070472)2.84852529
86regulation of mRNA 3-end processing (GO:0031440)2.84123732
87purine deoxyribonucleotide catabolic process (GO:0009155)2.81821495
88locomotory exploration behavior (GO:0035641)2.81594160
89musculoskeletal movement (GO:0050881)2.81414186
90multicellular organismal movement (GO:0050879)2.81414186
91multicellular organism reproduction (GO:0032504)2.79701321
92endoderm formation (GO:0001706)2.79679489
93positive regulation of digestive system process (GO:0060456)2.77861912
94alanine transport (GO:0032328)2.76280207
95regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.75573346
96pantothenate metabolic process (GO:0015939)2.73507623
97behavioral response to ethanol (GO:0048149)2.73034522
98S-adenosylmethionine metabolic process (GO:0046500)2.72737297
99indolalkylamine metabolic process (GO:0006586)2.72669495
100sequestering of extracellular ligand from receptor (GO:0035581)2.69590011

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.58094801
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.91511746
3ZNF274_21170338_ChIP-Seq_K562_Hela3.53406009
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.49304575
5IGF1R_20145208_ChIP-Seq_DFB_Human3.37944130
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36448321
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.29428280
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.26909546
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23853430
10GBX2_23144817_ChIP-Seq_PC3_Human2.03869656
11REST_21632747_ChIP-Seq_MESCs_Mouse1.97756510
12VDR_22108803_ChIP-Seq_LS180_Human1.97384493
13PCGF2_27294783_Chip-Seq_NPCs_Mouse1.89571787
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.88554802
15AR_21572438_ChIP-Seq_LNCaP_Human1.86342737
16ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80794477
17PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78995249
18DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.77825906
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.77365970
20CBX2_27304074_Chip-Seq_ESCs_Mouse1.76348720
21DROSHA_22980978_ChIP-Seq_HELA_Human1.71759889
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71221465
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68912164
24UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66820016
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65172455
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.61280830
27EWS_26573619_Chip-Seq_HEK293_Human1.57609217
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.55840170
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.54649728
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54531502
31KLF5_20875108_ChIP-Seq_MESCs_Mouse1.53097922
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52952947
33TAF15_26573619_Chip-Seq_HEK293_Human1.51540233
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.51163396
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50544260
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47607524
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43892867
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.42730292
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42245757
40RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.41117309
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38952286
42FUS_26573619_Chip-Seq_HEK293_Human1.37796482
43TP53_22573176_ChIP-Seq_HFKS_Human1.37332287
44SOX2_19829295_ChIP-Seq_ESCs_Human1.37326459
45NANOG_19829295_ChIP-Seq_ESCs_Human1.37326459
46STAT3_23295773_ChIP-Seq_U87_Human1.36828483
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36507574
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.33542979
49ER_23166858_ChIP-Seq_MCF-7_Human1.33327568
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.31905110
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31905110
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30601521
53P300_19829295_ChIP-Seq_ESCs_Human1.28643983
54RNF2_27304074_Chip-Seq_NSC_Mouse1.26767846
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26284727
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.26026041
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25753265
58BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24984669
59TCF4_23295773_ChIP-Seq_U87_Human1.24857031
60NCOR_22424771_ChIP-Seq_293T_Human1.24561721
61HOXB7_26014856_ChIP-Seq_BT474_Human1.23707813
62BCAT_22108803_ChIP-Seq_LS180_Human1.23357222
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.23227790
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22492240
65RNF2_18974828_ChIP-Seq_MESCs_Mouse1.21608289
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.21608289
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21297631
68FOXH1_21741376_ChIP-Seq_EPCs_Human1.21158539
69RUNX2_22187159_ChIP-Seq_PCA_Human1.18533606
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18287384
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18287384
72GATA1_26923725_Chip-Seq_HPCs_Mouse1.15031005
73AR_25329375_ChIP-Seq_VCAP_Human1.14070723
74SMAD4_21799915_ChIP-Seq_A2780_Human1.13610435
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12663825
76OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11657655
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.11536952
78TDRD3_21172665_ChIP-Seq_MCF-7_Human1.11140781
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.11054999
80GATA3_21878914_ChIP-Seq_MCF-7_Human1.10730110
81AR_20517297_ChIP-Seq_VCAP_Human1.10539722
82SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10448281
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10431154
84SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09950562
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08642514
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06900795
87CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06603964
88SMAD4_21741376_ChIP-Seq_EPCs_Human1.05602599
89SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05227914
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04289234
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03545428
92RNF2_27304074_Chip-Seq_ESCs_Mouse1.02905129
93SMAD3_21741376_ChIP-Seq_ESCs_Human1.01863108
94EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00633374
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.00581208
96NOTCH1_21737748_ChIP-Seq_TLL_Human0.99439858
97MTF2_20144788_ChIP-Seq_MESCs_Mouse0.99430717
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98647949
99ESR1_20079471_ChIP-ChIP_T-47D_Human0.97454547
100TP53_20018659_ChIP-ChIP_R1E_Mouse0.97075802

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.51307930
2MP0001968_abnormal_touch/_nociception3.97711928
3MP0003136_yellow_coat_color3.79162497
4MP0002736_abnormal_nociception_after3.32287732
5MP0003646_muscle_fatigue2.93351774
6MP0005671_abnormal_response_to2.50753132
7MP0005083_abnormal_biliary_tract2.50367907
8MP0006082_CNS_inflammation2.42635457
9MP0002734_abnormal_mechanical_nocicepti2.38302928
10MP0001661_extended_life_span2.36429192
11MP0004885_abnormal_endolymph2.33952901
12MP0002277_abnormal_respiratory_mucosa2.31885756
13MP0001764_abnormal_homeostasis2.29891224
14MP0001986_abnormal_taste_sensitivity2.28666918
15MP0008877_abnormal_DNA_methylation2.07698495
16MP0010368_abnormal_lymphatic_system2.07579033
17MP0004142_abnormal_muscle_tone1.93231963
18MP0005551_abnormal_eye_electrophysiolog1.90934906
19MP0001529_abnormal_vocalization1.88981417
20MP0009745_abnormal_behavioral_response1.75770179
21MP0001501_abnormal_sleep_pattern1.75315616
22MP0002876_abnormal_thyroid_physiology1.68378545
23MP0006292_abnormal_olfactory_placode1.65669585
24MP0004133_heterotaxia1.65008405
25MP0002163_abnormal_gland_morphology1.61333663
26MP0008875_abnormal_xenobiotic_pharmacok1.59830797
27MP0008872_abnormal_physiological_respon1.56399485
28MP0002933_joint_inflammation1.55962858
29MP0002735_abnormal_chemical_nociception1.55091598
30MP0000685_abnormal_immune_system1.53539240
31MP0009046_muscle_twitch1.50120827
32MP0002272_abnormal_nervous_system1.48833508
33MP0001485_abnormal_pinna_reflex1.47996777
34MP0005423_abnormal_somatic_nervous1.46731034
35MP0005253_abnormal_eye_physiology1.45548502
36MP0006276_abnormal_autonomic_nervous1.45397440
37MP0003195_calcinosis1.43561649
38MP0008874_decreased_physiological_sensi1.42692097
39MP0002837_dystrophic_cardiac_calcinosis1.39584995
40MP0000569_abnormal_digit_pigmentation1.38674537
41MP0002132_abnormal_respiratory_system1.34880047
42MP0004084_abnormal_cardiac_muscle1.33064408
43MP0005220_abnormal_exocrine_pancreas1.31649883
44MP0002557_abnormal_social/conspecific_i1.28556406
45MP0003183_abnormal_peptide_metabolism1.28503838
46MP0008057_abnormal_DNA_replication1.26304057
47MP0005646_abnormal_pituitary_gland1.22819678
48MP0002572_abnormal_emotion/affect_behav1.22453300
49MP0000013_abnormal_adipose_tissue1.22113010
50MP0005075_abnormal_melanosome_morpholog1.19610610
51MP0001970_abnormal_pain_threshold1.15171246
52MP0004381_abnormal_hair_follicle1.12585192
53MP0003638_abnormal_response/metabolism_1.08440294
54MP0004145_abnormal_muscle_electrophysio1.05046804
55MP0002064_seizures1.03356361
56MP0003283_abnormal_digestive_organ1.01688792
57MP0001486_abnormal_startle_reflex1.00156612
58MP0000778_abnormal_nervous_system0.96944306
59MP0009384_cardiac_valve_regurgitation0.95848461
60MP0001800_abnormal_humoral_immune0.94295684
61MP0002063_abnormal_learning/memory/cond0.92515726
62MP0004019_abnormal_vitamin_homeostasis0.91978151
63MP0002234_abnormal_pharynx_morphology0.91656874
64MP0004924_abnormal_behavior0.90910795
65MP0005386_behavior/neurological_phenoty0.90910795
66MP0008569_lethality_at_weaning0.90428966
67MP0000631_abnormal_neuroendocrine_gland0.90263744
68MP0003690_abnormal_glial_cell0.89804392
69MP0001440_abnormal_grooming_behavior0.89281316
70MP0001790_abnormal_immune_system0.86434001
71MP0005387_immune_system_phenotype0.86434001
72MP0000230_abnormal_systemic_arterial0.85567983
73MP0002067_abnormal_sensory_capabilities0.83763410
74MP0001502_abnormal_circadian_rhythm0.83301816
75MP0003763_abnormal_thymus_physiology0.82644878
76MP0002693_abnormal_pancreas_physiology0.82599304
77MP0002210_abnormal_sex_determination0.81542218
78MP0005195_abnormal_posterior_eye0.81300068
79MP0005376_homeostasis/metabolism_phenot0.81041231
80MP0003943_abnormal_hepatobiliary_system0.81028061
81MP0003866_abnormal_defecation0.79470361
82MP0000026_abnormal_inner_ear0.79307726
83MP0003137_abnormal_impulse_conducting0.78727341
84MP0002733_abnormal_thermal_nociception0.77977249
85MP0003635_abnormal_synaptic_transmissio0.77412364
86MP0003950_abnormal_plasma_membrane0.76462250
87MP0003045_fibrosis0.76022474
88MP0003119_abnormal_digestive_system0.75178232
89MP0004043_abnormal_pH_regulation0.73893590
90MP0005410_abnormal_fertilization0.73615871
91MP0001324_abnormal_eye_pigmentation0.72816292
92MP0008004_abnormal_stomach_pH0.71259676
93MP0004147_increased_porphyrin_level0.70912495
94MP0001929_abnormal_gametogenesis0.69512114
95MP0001765_abnormal_ion_homeostasis0.68014287
96MP0005266_abnormal_metabolism0.67573643
97MP0005379_endocrine/exocrine_gland_phen0.67246253
98MP0005167_abnormal_blood-brain_barrier0.65760141
99MP0001963_abnormal_hearing_physiology0.65575577
100MP0000639_abnormal_adrenal_gland0.65524864

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the pons (HP:0007361)6.49747141
2Hypoplasia of the pons (HP:0012110)6.35632399
3Biconcave vertebral bodies (HP:0004586)4.61885623
4Congenital stationary night blindness (HP:0007642)4.37321751
5Abnormality of the vertebral endplates (HP:0005106)4.33780753
6Cerebral palsy (HP:0100021)3.56547214
7Hyperventilation (HP:0002883)3.46609512
8Poor suck (HP:0002033)3.46131754
9Type II lissencephaly (HP:0007260)3.35811478
10Hyperlipoproteinemia (HP:0010980)3.35063577
11Pancreatic fibrosis (HP:0100732)3.33322908
12Acute lymphatic leukemia (HP:0006721)3.17698862
13Attenuation of retinal blood vessels (HP:0007843)3.14075640
14Abnormality of the femoral head (HP:0003368)3.01464749
15Irregular vertebral endplates (HP:0003301)2.97461228
16Abnormality of cochlea (HP:0000375)2.93781661
17Decreased electroretinogram (ERG) amplitude (HP:0000654)2.87916308
18True hermaphroditism (HP:0010459)2.86286509
19Flat capital femoral epiphysis (HP:0003370)2.84706960
20Broad-based gait (HP:0002136)2.82265217
21Abnormality of the renal collecting system (HP:0004742)2.79586887
22Pancreatic cysts (HP:0001737)2.76618889
23Visual hallucinations (HP:0002367)2.75711189
24Duplicated collecting system (HP:0000081)2.72968185
25Neurodegeneration (HP:0002180)2.71196412
26Abnormality of secondary sexual hair (HP:0009888)2.67437415
27Abnormality of the axillary hair (HP:0100134)2.67437415
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.67335872
29Abnormality of alanine metabolism (HP:0010916)2.67335872
30Hyperalaninemia (HP:0003348)2.67335872
31Type 2 muscle fiber atrophy (HP:0003554)2.67079615
32Hypoproteinemia (HP:0003075)2.66997374
33Dyskinesia (HP:0100660)2.62842852
34Morphological abnormality of the inner ear (HP:0011390)2.60665686
35J-shaped sella turcica (HP:0002680)2.57806814
36Broad face (HP:0000283)2.56261706
37Inability to walk (HP:0002540)2.54541178
38Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.52058237
39Chin dimple (HP:0010751)2.51359300
40Genetic anticipation (HP:0003743)2.50437081
41Abnormality of the epiphysis of the femoral head (HP:0010574)2.47407587
42Dysautonomia (HP:0002459)2.47239984
43Impaired smooth pursuit (HP:0007772)2.46447812
44Cerebellar dysplasia (HP:0007033)2.46318758
45Molar tooth sign on MRI (HP:0002419)2.46267596
46Abnormality of midbrain morphology (HP:0002418)2.46267596
47Abnormality of proline metabolism (HP:0010907)2.45601959
48Hydroxyprolinuria (HP:0003080)2.45601959
49Ulnar claw (HP:0001178)2.42004645
50Chorioretinal atrophy (HP:0000533)2.38948202
51Opisthotonus (HP:0002179)2.36541136
52Increased serum ferritin (HP:0003281)2.34364492
53Irregular epiphyses (HP:0010582)2.34118723
54Nonprogressive disorder (HP:0003680)2.28622339
55Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.22329984
56Abnormality of femoral epiphyses (HP:0006499)2.22329984
57Muscle fiber atrophy (HP:0100295)2.19079797
58Pendular nystagmus (HP:0012043)2.18763261
59Patellar aplasia (HP:0006443)2.15908105
60Fair hair (HP:0002286)2.15786868
61Progressive cerebellar ataxia (HP:0002073)2.13294339
62Hypoplasia of the odontoid process (HP:0003311)2.13269200
63Restlessness (HP:0000711)2.12091035
64Abolished electroretinogram (ERG) (HP:0000550)2.08350529
65Epidermoid cyst (HP:0200040)2.08133033
66Hyperparathyroidism (HP:0000843)2.06805997
67Aplasia/Hypoplasia of the patella (HP:0006498)2.04736795
68Impaired proprioception (HP:0010831)2.04638267
69Enlarged epiphyses (HP:0010580)2.03602063
70Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.02785107
71Clumsiness (HP:0002312)2.02105047
72Progressive microcephaly (HP:0000253)2.01351183
73Furrowed tongue (HP:0000221)2.00906022
74Cystic liver disease (HP:0006706)2.00058654
75Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.99747819
76Progressive inability to walk (HP:0002505)1.98767830
77Abnormality of the neuromuscular junction (HP:0003398)1.98298721
78Fatigable weakness (HP:0003473)1.98298721
79Hemiplegia (HP:0002301)1.96912531
80Abnormality of transition element cation homeostasis (HP:0011030)1.95078359
81Large for gestational age (HP:0001520)1.95055454
82Birth length less than 3rd percentile (HP:0003561)1.92554960
83Abnormality of ocular smooth pursuit (HP:0000617)1.92339048
84Aplasia/Hypoplasia of the spleen (HP:0010451)1.89318910
85Aplasia/Hypoplasia of the fovea (HP:0008060)1.89131893
86Hypoplasia of the fovea (HP:0007750)1.89131893
87Sclerocornea (HP:0000647)1.87989632
88Limited hip movement (HP:0008800)1.87921874
89Protruding tongue (HP:0010808)1.87905207
90Ventricular fibrillation (HP:0001663)1.87193953
91Easy fatigability (HP:0003388)1.86893572
92Hypoplasia of the brainstem (HP:0002365)1.86416860
93Aplasia/Hypoplasia of the brainstem (HP:0007362)1.86416860
94Aplasia/hypoplasia of the femur (HP:0005613)1.85710755
95Asplenia (HP:0001746)1.83556072
96Hip contracture (HP:0003273)1.81935508
97Difficulty walking (HP:0002355)1.81805146
98Autoimmune hemolytic anemia (HP:0001890)1.80571455
99Flared iliac wings (HP:0002869)1.80263841
100Scotoma (HP:0000575)1.79142306

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK17.46091452
2FRK5.68553020
3KDR3.92845975
4ADRBK23.25457763
5ZAK2.81704120
6DAPK22.80721454
7PNCK2.49854941
8MKNK22.21873191
9SIK22.07040482
10RIPK42.01301140
11MAP3K111.94458832
12EPHA41.93146354
13BLK1.91845767
14TIE11.87066513
15VRK21.81200166
16TRPM71.77752325
17NUAK11.63065621
18STK381.57376821
19TAF11.50297572
20DAPK11.48740889
21BMPR1B1.38806198
22SGK21.31524237
23PTK2B1.28116885
24TXK1.27519746
25MAP3K51.24339926
26LATS11.23994352
27FGR1.23764927
28ADRBK11.22103403
29INSRR1.19756833
30MAP4K11.15109042
31ACVR1B1.13806198
32ITK1.11407455
33MUSK1.06995079
34EIF2AK31.04477631
35MKNK11.02159786
36NEK91.01878815
37TGFBR10.95928918
38MELK0.90546319
39SGK4940.87309212
40SGK2230.87309212
41GRK50.85768486
42WNK30.83575109
43STK40.79290944
44ALK0.77956581
45NEK20.74986656
46ERBB30.73045923
47CSF1R0.72241791
48GRK10.69531304
49LYN0.67766288
50TNK20.65711693
51FES0.65074141
52ZAP700.62205662
53PRKCG0.60726974
54SYK0.60696256
55YES10.60235166
56CAMK40.60010858
57CAMK2A0.59787072
58FLT30.58797700
59CASK0.58382116
60KIT0.57747442
61DYRK30.54166765
62IKBKB0.53404653
63HCK0.51825807
64PRKCH0.51816977
65NTRK20.51816223
66IKBKE0.47852767
67SGK10.46747062
68CAMK10.46020375
69PRKCZ0.45604260
70RET0.42634065
71RPS6KB10.42595168
72GRK60.42227049
73VRK10.42013030
74SGK30.41708232
75DAPK30.41545291
76HIPK20.40884431
77TEC0.40086741
78TYK20.39202349
79MAPK110.37769657
80EIF2AK20.36998302
81GSK3A0.35764505
82PRKCQ0.33147389
83IGF1R0.32931705
84PDK10.31864159
85ABL10.31849436
86PRKCE0.30845802
87LCK0.29244178
88AURKA0.27433892
89PTK60.26336223
90DYRK20.26226662
91TSSK60.25582357
92PDK20.24761365
93TAOK10.24219494
94PKN10.23130421
95PLK10.21952529
96RPS6KA60.21623445
97PLK20.20948068
98CAMK2B0.20582360
99PRKG20.20457746
100SRC0.20325739

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.52217984
2Nicotine addiction_Homo sapiens_hsa050333.63720714
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.41607148
4Linoleic acid metabolism_Homo sapiens_hsa005913.33455641
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.71793765
6Morphine addiction_Homo sapiens_hsa050322.56214051
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.36127807
8Ether lipid metabolism_Homo sapiens_hsa005652.26099972
9GABAergic synapse_Homo sapiens_hsa047272.23422214
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.12877790
11Primary immunodeficiency_Homo sapiens_hsa053401.99900053
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.99825648
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.77459694
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.77129253
15ABC transporters_Homo sapiens_hsa020101.72258184
16Proteasome_Homo sapiens_hsa030501.71855207
17Olfactory transduction_Homo sapiens_hsa047401.44467615
18Glutamatergic synapse_Homo sapiens_hsa047241.43990628
19Histidine metabolism_Homo sapiens_hsa003401.40786480
20Caffeine metabolism_Homo sapiens_hsa002321.35621588
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29117063
22Graft-versus-host disease_Homo sapiens_hsa053321.27568139
23Circadian entrainment_Homo sapiens_hsa047131.26417549
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.26275289
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25546544
26Nitrogen metabolism_Homo sapiens_hsa009101.23361945
27Ovarian steroidogenesis_Homo sapiens_hsa049131.20710204
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.19340783
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17789128
30Tryptophan metabolism_Homo sapiens_hsa003801.17376933
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17253177
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16531703
33Serotonergic synapse_Homo sapiens_hsa047261.15272729
34Huntingtons disease_Homo sapiens_hsa050161.12555391
35Oxidative phosphorylation_Homo sapiens_hsa001901.12523958
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10041296
37Arachidonic acid metabolism_Homo sapiens_hsa005901.06046520
38Carbohydrate digestion and absorption_Homo sapiens_hsa049731.05107965
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02669157
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02491811
41Selenocompound metabolism_Homo sapiens_hsa004501.02014508
42Dorso-ventral axis formation_Homo sapiens_hsa043200.94296355
43Antigen processing and presentation_Homo sapiens_hsa046120.93979888
44Glycerolipid metabolism_Homo sapiens_hsa005610.93213883
45Calcium signaling pathway_Homo sapiens_hsa040200.89650019
46Sulfur relay system_Homo sapiens_hsa041220.88518999
47Glycerophospholipid metabolism_Homo sapiens_hsa005640.88257181
48RNA polymerase_Homo sapiens_hsa030200.85438953
49Hematopoietic cell lineage_Homo sapiens_hsa046400.83547017
50Renin-angiotensin system_Homo sapiens_hsa046140.81804411
51Long-term depression_Homo sapiens_hsa047300.81245649
52Regulation of autophagy_Homo sapiens_hsa041400.79829149
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77156474
54Autoimmune thyroid disease_Homo sapiens_hsa053200.77028013
55Insulin secretion_Homo sapiens_hsa049110.76120209
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75979039
57Chemical carcinogenesis_Homo sapiens_hsa052040.75950938
58Allograft rejection_Homo sapiens_hsa053300.75622889
59Retinol metabolism_Homo sapiens_hsa008300.75467132
60Basal cell carcinoma_Homo sapiens_hsa052170.71367572
61Type I diabetes mellitus_Homo sapiens_hsa049400.70819541
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70770862
63Mineral absorption_Homo sapiens_hsa049780.70754365
64Cardiac muscle contraction_Homo sapiens_hsa042600.68826376
65Parkinsons disease_Homo sapiens_hsa050120.68667786
66Butanoate metabolism_Homo sapiens_hsa006500.67326424
67Taste transduction_Homo sapiens_hsa047420.66422259
68beta-Alanine metabolism_Homo sapiens_hsa004100.66269125
69Fanconi anemia pathway_Homo sapiens_hsa034600.65114418
70Cholinergic synapse_Homo sapiens_hsa047250.64083125
71Homologous recombination_Homo sapiens_hsa034400.62275004
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59614148
73Synaptic vesicle cycle_Homo sapiens_hsa047210.59372745
74RNA degradation_Homo sapiens_hsa030180.59349650
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59174107
76One carbon pool by folate_Homo sapiens_hsa006700.58884932
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.58526381
78Basal transcription factors_Homo sapiens_hsa030220.55428202
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55416400
80Alzheimers disease_Homo sapiens_hsa050100.53011673
81Salivary secretion_Homo sapiens_hsa049700.52670405
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52332517
83Fat digestion and absorption_Homo sapiens_hsa049750.51607154
84Dopaminergic synapse_Homo sapiens_hsa047280.49404809
85Protein digestion and absorption_Homo sapiens_hsa049740.49043345
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48931836
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42818572
88Asthma_Homo sapiens_hsa053100.42646787
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.41412237
90Ribosome_Homo sapiens_hsa030100.40963776
91TNF signaling pathway_Homo sapiens_hsa046680.40100122
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39671681
93Starch and sucrose metabolism_Homo sapiens_hsa005000.34161423
94Pancreatic secretion_Homo sapiens_hsa049720.33396039
95Vitamin digestion and absorption_Homo sapiens_hsa049770.32901753
96African trypanosomiasis_Homo sapiens_hsa051430.32315105
97Hedgehog signaling pathway_Homo sapiens_hsa043400.31124051
98ECM-receptor interaction_Homo sapiens_hsa045120.29951487
99Systemic lupus erythematosus_Homo sapiens_hsa053220.27380674
100Shigellosis_Homo sapiens_hsa051310.26807344

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