

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 5.84699218 |
| 2 | viral transcription (GO:0019083) | 5.12553197 |
| 3 | ribosomal small subunit biogenesis (GO:0042274) | 5.00203450 |
| 4 | translational termination (GO:0006415) | 4.98055956 |
| 5 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.89752951 |
| 6 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.78247472 |
| 7 | maturation of SSU-rRNA (GO:0030490) | 4.72303321 |
| 8 | DNA strand elongation (GO:0022616) | 4.66010495 |
| 9 | translational elongation (GO:0006414) | 4.54891446 |
| 10 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.46647124 |
| 11 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.36866213 |
| 12 | cotranslational protein targeting to membrane (GO:0006613) | 4.35478632 |
| 13 | chaperone-mediated protein transport (GO:0072321) | 4.32539071 |
| 14 | protein targeting to ER (GO:0045047) | 4.32420598 |
| 15 | formation of translation preinitiation complex (GO:0001731) | 4.30931222 |
| 16 | DNA replication initiation (GO:0006270) | 4.28136406 |
| 17 | regulation of mitochondrial translation (GO:0070129) | 4.27929711 |
| 18 | telomere maintenance via recombination (GO:0000722) | 4.23749436 |
| 19 | proteasome assembly (GO:0043248) | 4.21780579 |
| 20 | nucleobase biosynthetic process (GO:0046112) | 4.21213559 |
| 21 | translational initiation (GO:0006413) | 4.19776375 |
| 22 | DNA deamination (GO:0045006) | 4.16467764 |
| 23 | ribosomal large subunit biogenesis (GO:0042273) | 4.13693107 |
| 24 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.13158608 |
| 25 | purine nucleobase biosynthetic process (GO:0009113) | 4.12694581 |
| 26 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.11001780 |
| 27 | DNA unwinding involved in DNA replication (GO:0006268) | 4.09783132 |
| 28 | protein localization to endoplasmic reticulum (GO:0070972) | 4.08075544 |
| 29 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.07489135 |
| 30 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.02823470 |
| 31 | mitotic recombination (GO:0006312) | 4.00835080 |
| 32 | viral life cycle (GO:0019058) | 3.96557164 |
| 33 | ATP synthesis coupled proton transport (GO:0015986) | 3.96352970 |
| 34 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.96352970 |
| 35 | cellular protein complex disassembly (GO:0043624) | 3.96303022 |
| 36 | protein targeting to mitochondrion (GO:0006626) | 3.85841540 |
| 37 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.81331634 |
| 38 | CENP-A containing nucleosome assembly (GO:0034080) | 3.78151036 |
| 39 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.77469405 |
| 40 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.76806944 |
| 41 | chromatin remodeling at centromere (GO:0031055) | 3.74781758 |
| 42 | telomere maintenance via telomere lengthening (GO:0010833) | 3.74447180 |
| 43 | DNA replication checkpoint (GO:0000076) | 3.67944619 |
| 44 | ribosome biogenesis (GO:0042254) | 3.67127354 |
| 45 | oxidative phosphorylation (GO:0006119) | 3.65777793 |
| 46 | spliceosomal snRNP assembly (GO:0000387) | 3.62928791 |
| 47 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.61641577 |
| 48 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.61641577 |
| 49 | translation (GO:0006412) | 3.59638045 |
| 50 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.57905148 |
| 51 | establishment of integrated proviral latency (GO:0075713) | 3.57135854 |
| 52 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.56666799 |
| 53 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.55180093 |
| 54 | protein complex disassembly (GO:0043241) | 3.55000461 |
| 55 | protein complex biogenesis (GO:0070271) | 3.52107785 |
| 56 | establishment of protein localization to mitochondrion (GO:0072655) | 3.52070117 |
| 57 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.51928140 |
| 58 | respiratory electron transport chain (GO:0022904) | 3.51223533 |
| 59 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.50752297 |
| 60 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.50668514 |
| 61 | kinetochore organization (GO:0051383) | 3.50351271 |
| 62 | protein deneddylation (GO:0000338) | 3.50070227 |
| 63 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.48961157 |
| 64 | cullin deneddylation (GO:0010388) | 3.47724394 |
| 65 | protein localization to kinetochore (GO:0034501) | 3.46825149 |
| 66 | protein localization to mitochondrion (GO:0070585) | 3.46134228 |
| 67 | mitotic nuclear envelope disassembly (GO:0007077) | 3.45547956 |
| 68 | mitotic metaphase plate congression (GO:0007080) | 3.45378520 |
| 69 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.44411706 |
| 70 | negative regulation of ligase activity (GO:0051352) | 3.44411706 |
| 71 | rRNA processing (GO:0006364) | 3.42743576 |
| 72 | regulation of ligase activity (GO:0051340) | 3.42023636 |
| 73 | metallo-sulfur cluster assembly (GO:0031163) | 3.41590559 |
| 74 | iron-sulfur cluster assembly (GO:0016226) | 3.41590559 |
| 75 | electron transport chain (GO:0022900) | 3.40579410 |
| 76 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.39825254 |
| 77 | DNA replication-independent nucleosome organization (GO:0034724) | 3.37912555 |
| 78 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.37912555 |
| 79 | macromolecular complex disassembly (GO:0032984) | 3.37731021 |
| 80 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.33540467 |
| 81 | mitotic sister chromatid segregation (GO:0000070) | 3.32128972 |
| 82 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.31548592 |
| 83 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.31548592 |
| 84 | NADH dehydrogenase complex assembly (GO:0010257) | 3.31548592 |
| 85 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.31246014 |
| 86 | kinetochore assembly (GO:0051382) | 3.29937511 |
| 87 | rRNA metabolic process (GO:0016072) | 3.29371577 |
| 88 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.28550858 |
| 89 | protein maturation by protein folding (GO:0022417) | 3.27650536 |
| 90 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.25500970 |
| 91 | cellular component biogenesis (GO:0044085) | 3.25308821 |
| 92 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.24772440 |
| 93 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.24206932 |
| 94 | viral mRNA export from host cell nucleus (GO:0046784) | 3.21520897 |
| 95 | respiratory chain complex IV assembly (GO:0008535) | 3.19727884 |
| 96 | pseudouridine synthesis (GO:0001522) | 3.19577895 |
| 97 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.19296664 |
| 98 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.19296664 |
| 99 | membrane disassembly (GO:0030397) | 3.18000020 |
| 100 | nuclear envelope disassembly (GO:0051081) | 3.18000020 |
| 101 | inner mitochondrial membrane organization (GO:0007007) | 3.17722457 |
| 102 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.16453286 |
| 103 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.16453286 |
| 104 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.16453286 |
| 105 | base-excision repair (GO:0006284) | 3.16155592 |
| 106 | purine deoxyribonucleotide catabolic process (GO:0009155) | 3.15832618 |
| 107 | rRNA modification (GO:0000154) | 3.15669930 |
| 108 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.14878875 |
| 109 | spliceosomal complex assembly (GO:0000245) | 3.13916138 |
| 110 | deoxyribonucleotide catabolic process (GO:0009264) | 3.13092361 |
| 111 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.12755874 |
| 112 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.12755874 |
| 113 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.11281379 |
| 114 | base-excision repair, AP site formation (GO:0006285) | 3.10094349 |
| 115 | positive regulation of cell cycle arrest (GO:0071158) | 3.10056827 |
| 116 | cell cycle G1/S phase transition (GO:0044843) | 3.09534547 |
| 117 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.09534547 |
| 118 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.09529884 |
| 119 | mRNA catabolic process (GO:0006402) | 3.07774545 |
| 120 | cytochrome complex assembly (GO:0017004) | 3.07648436 |
| 121 | deoxyribose phosphate catabolic process (GO:0046386) | 3.07324494 |
| 122 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.06839674 |
| 123 | ribosome assembly (GO:0042255) | 3.04193741 |
| 124 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.03688690 |
| 125 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.02950194 |
| 126 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.00270952 |
| 127 | metaphase plate congression (GO:0051310) | 2.99663161 |
| 128 | IMP biosynthetic process (GO:0006188) | 2.98818572 |
| 129 | RNA catabolic process (GO:0006401) | 2.97220920 |
| 130 | histone exchange (GO:0043486) | 2.93453832 |
| 131 | mitotic chromosome condensation (GO:0007076) | 2.93432718 |
| 132 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.92842859 |
| 133 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.90834065 |
| 134 | termination of RNA polymerase III transcription (GO:0006386) | 2.90834065 |
| 135 | positive regulation of ligase activity (GO:0051351) | 2.88636943 |
| 136 | protein localization to chromosome, centromeric region (GO:0071459) | 2.88409671 |
| 137 | nucleobase-containing small molecule interconversion (GO:0015949) | 2.82164357 |
| 138 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.81655624 |
| 139 | establishment of viral latency (GO:0019043) | 2.81362187 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.76509649 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.59470633 |
| 3 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.09650407 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.84220606 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.31896537 |
| 6 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.24893181 |
| 7 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.23424433 |
| 8 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.17216922 |
| 9 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.13380415 |
| 10 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.09658239 |
| 11 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.02018595 |
| 12 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.01836996 |
| 13 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.95404606 |
| 14 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.92487060 |
| 15 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.86447621 |
| 16 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.76850275 |
| 17 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.76422829 |
| 18 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.56499211 |
| 19 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.51999615 |
| 20 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.48287260 |
| 21 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.45487283 |
| 22 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.31683543 |
| 23 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.30903653 |
| 24 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.28419379 |
| 25 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.26544681 |
| 26 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.15069257 |
| 27 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.06659705 |
| 28 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.05447285 |
| 29 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.01462863 |
| 30 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.96420562 |
| 31 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.96020280 |
| 32 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.95647585 |
| 33 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.92417591 |
| 34 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.78936170 |
| 35 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.78220343 |
| 36 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.77788684 |
| 37 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.75058582 |
| 38 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.74161864 |
| 39 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.72532003 |
| 40 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.72074820 |
| 41 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.70343410 |
| 42 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.70136015 |
| 43 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.66836469 |
| 44 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.66032668 |
| 45 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.64303087 |
| 46 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.62345143 |
| 47 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.61134219 |
| 48 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.56476485 |
| 49 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.54245039 |
| 50 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.47926327 |
| 51 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.45959783 |
| 52 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.41889674 |
| 53 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.40766188 |
| 54 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.40327900 |
| 55 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.36664572 |
| 56 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.30137769 |
| 57 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.28059980 |
| 58 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.26531047 |
| 59 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.25645539 |
| 60 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.24684659 |
| 61 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.23722226 |
| 62 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.22631429 |
| 63 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.21061273 |
| 64 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.20130040 |
| 65 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.18464435 |
| 66 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.18305863 |
| 67 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.18037684 |
| 68 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.15265728 |
| 69 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.14889168 |
| 70 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.12998456 |
| 71 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.12073516 |
| 72 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.10351128 |
| 73 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.10236117 |
| 74 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.08434672 |
| 75 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.06923334 |
| 76 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.05811911 |
| 77 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.05129810 |
| 78 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.04904584 |
| 79 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.04354376 |
| 80 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.03303550 |
| 81 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.03163502 |
| 82 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.01413379 |
| 83 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.99201662 |
| 84 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.99022213 |
| 85 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.98032889 |
| 86 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.97833097 |
| 87 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.97395153 |
| 88 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.95689435 |
| 89 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.94816548 |
| 90 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.94017528 |
| 91 | MYC_22102868_ChIP-Seq_BL_Human | 0.93888021 |
| 92 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.92316793 |
| 93 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.92294598 |
| 94 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.91959697 |
| 95 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.91471413 |
| 96 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.90027870 |
| 97 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.89860705 |
| 98 | * TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.88970519 |
| 99 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.87553436 |
| 100 | VDR_21846776_ChIP-Seq_THP-1_Human | 0.87172121 |
| 101 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.87045003 |
| 102 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.86871856 |
| 103 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.86647691 |
| 104 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.86456388 |
| 105 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.84912686 |
| 106 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.83489090 |
| 107 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.83468190 |
| 108 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.82211080 |
| 109 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.81213483 |
| 110 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.80168242 |
| 111 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.80064626 |
| 112 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.78869410 |
| 113 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.78360025 |
| 114 | * ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.76468612 |
| 115 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.74311546 |
| 116 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.74246338 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.12990193 |
| 2 | MP0010094_abnormal_chromosome_stability | 4.07469212 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 4.03769210 |
| 4 | MP0003111_abnormal_nucleus_morphology | 3.78491905 |
| 5 | MP0003077_abnormal_cell_cycle | 3.67445709 |
| 6 | MP0008058_abnormal_DNA_repair | 3.25936749 |
| 7 | MP0008057_abnormal_DNA_replication | 2.98673089 |
| 8 | MP0008932_abnormal_embryonic_tissue | 2.76940583 |
| 9 | MP0003806_abnormal_nucleotide_metabolis | 2.74608159 |
| 10 | MP0008007_abnormal_cellular_replicative | 2.66331448 |
| 11 | MP0003123_paternal_imprinting | 2.47125318 |
| 12 | MP0003786_premature_aging | 2.22311289 |
| 13 | MP0002396_abnormal_hematopoietic_system | 2.18534424 |
| 14 | MP0009379_abnormal_foot_pigmentation | 2.18497098 |
| 15 | MP0000372_irregular_coat_pigmentation | 2.16560222 |
| 16 | MP0010030_abnormal_orbit_morphology | 2.08956551 |
| 17 | MP0001730_embryonic_growth_arrest | 1.90250825 |
| 18 | MP0000350_abnormal_cell_proliferation | 1.85958402 |
| 19 | MP0002938_white_spotting | 1.75590597 |
| 20 | MP0003718_maternal_effect | 1.75232048 |
| 21 | MP0000490_abnormal_crypts_of | 1.56357204 |
| 22 | MP0006292_abnormal_olfactory_placode | 1.55369734 |
| 23 | MP0009697_abnormal_copulation | 1.54115134 |
| 24 | MP0004147_increased_porphyrin_level | 1.53168714 |
| 25 | MP0003315_abnormal_perineum_morphology | 1.52646478 |
| 26 | MP0001293_anophthalmia | 1.45988977 |
| 27 | MP0003186_abnormal_redox_activity | 1.43421462 |
| 28 | MP0003941_abnormal_skin_development | 1.37180742 |
| 29 | MP0002102_abnormal_ear_morphology | 1.34774227 |
| 30 | MP0003567_abnormal_fetal_cardiomyocyte | 1.34476719 |
| 31 | MP0001697_abnormal_embryo_size | 1.32673796 |
| 32 | MP0002080_prenatal_lethality | 1.29577729 |
| 33 | MP0005380_embryogenesis_phenotype | 1.27286412 |
| 34 | MP0001672_abnormal_embryogenesis/_devel | 1.27286412 |
| 35 | MP0002019_abnormal_tumor_incidence | 1.24235852 |
| 36 | MP0002234_abnormal_pharynx_morphology | 1.23922792 |
| 37 | MP0003121_genomic_imprinting | 1.21290152 |
| 38 | MP0003890_abnormal_embryonic-extraembry | 1.20799434 |
| 39 | MP0008438_abnormal_cutaneous_collagen | 1.20619710 |
| 40 | MP0000313_abnormal_cell_death | 1.18645953 |
| 41 | MP0002085_abnormal_embryonic_tissue | 1.18217295 |
| 42 | MP0004133_heterotaxia | 1.17449098 |
| 43 | MP0005075_abnormal_melanosome_morpholog | 1.17123668 |
| 44 | MP0000015_abnormal_ear_pigmentation | 1.16908609 |
| 45 | MP0003119_abnormal_digestive_system | 1.13323709 |
| 46 | MP0002163_abnormal_gland_morphology | 1.12669353 |
| 47 | MP0004197_abnormal_fetal_growth/weight/ | 1.12502127 |
| 48 | MP0009053_abnormal_anal_canal | 1.09828258 |
| 49 | MP0000049_abnormal_middle_ear | 1.09108692 |
| 50 | MP0003984_embryonic_growth_retardation | 1.09056795 |
| 51 | MP0002088_abnormal_embryonic_growth/wei | 1.07287632 |
| 52 | MP0002210_abnormal_sex_determination | 1.05187190 |
| 53 | MP0010352_gastrointestinal_tract_polyps | 1.04694146 |
| 54 | MP0008873_increased_physiological_sensi | 1.03891922 |
| 55 | MP0001853_heart_inflammation | 1.03786935 |
| 56 | MP0008877_abnormal_DNA_methylation | 1.02798428 |
| 57 | MP0008260_abnormal_autophagy | 1.01909095 |
| 58 | MP0005501_abnormal_skin_physiology | 1.01298758 |
| 59 | MP0002736_abnormal_nociception_after | 1.00232164 |
| 60 | MP0002084_abnormal_developmental_patter | 1.00069904 |
| 61 | MP0000566_synostosis | 1.00011243 |
| 62 | MP0002111_abnormal_tail_morphology | 0.97935671 |
| 63 | MP0005503_abnormal_tendon_morphology | 0.96237462 |
| 64 | MP0000537_abnormal_urethra_morphology | 0.95284631 |
| 65 | MP0005058_abnormal_lysosome_morphology | 0.94264660 |
| 66 | MP0001727_abnormal_embryo_implantation | 0.93521620 |
| 67 | MP0000858_altered_metastatic_potential | 0.93280638 |
| 68 | MP0001145_abnormal_male_reproductive | 0.92992427 |
| 69 | MP0002751_abnormal_autonomic_nervous | 0.92577564 |
| 70 | MP0002160_abnormal_reproductive_system | 0.92298453 |
| 71 | MP0000678_abnormal_parathyroid_gland | 0.92161739 |
| 72 | MP0001661_extended_life_span | 0.91607582 |
| 73 | MP0002086_abnormal_extraembryonic_tissu | 0.91513045 |
| 74 | MP0006036_abnormal_mitochondrial_physio | 0.90743465 |
| 75 | MP0009333_abnormal_splenocyte_physiolog | 0.90082591 |
| 76 | MP0005670_abnormal_white_adipose | 0.88587707 |
| 77 | MP0000358_abnormal_cell_content/ | 0.88518120 |
| 78 | MP0004808_abnormal_hematopoietic_stem | 0.88204560 |
| 79 | MP0005330_cardiomyopathy | 0.87372246 |
| 80 | MP0001346_abnormal_lacrimal_gland | 0.86330724 |
| 81 | MP0006054_spinal_hemorrhage | 0.83430788 |
| 82 | MP0001119_abnormal_female_reproductive | 0.83297233 |
| 83 | MP0001529_abnormal_vocalization | 0.83140862 |
| 84 | MP0002282_abnormal_trachea_morphology | 0.82559468 |
| 85 | MP0005023_abnormal_wound_healing | 0.81571093 |
| 86 | MP0002132_abnormal_respiratory_system | 0.80828229 |
| 87 | MP0002095_abnormal_skin_pigmentation | 0.79989911 |
| 88 | MP0000749_muscle_degeneration | 0.79662227 |
| 89 | MP0003942_abnormal_urinary_system | 0.77300931 |
| 90 | MP0000689_abnormal_spleen_morphology | 0.76421886 |
| 91 | MP0000653_abnormal_sex_gland | 0.75578650 |
| 92 | MP0006035_abnormal_mitochondrial_morpho | 0.75367671 |
| 93 | MP0002722_abnormal_immune_system | 0.75367463 |
| 94 | MP0005397_hematopoietic_system_phenotyp | 0.75060107 |
| 95 | MP0001545_abnormal_hematopoietic_system | 0.75060107 |
| 96 | MP0008789_abnormal_olfactory_epithelium | 0.74761053 |
| 97 | MP0005384_cellular_phenotype | 0.74086784 |
| 98 | MP0003698_abnormal_male_reproductive | 0.73544912 |
| 99 | MP0005266_abnormal_metabolism | 0.73033446 |
| 100 | MP0003221_abnormal_cardiomyocyte_apopto | 0.72905243 |
| 101 | MP0008995_early_reproductive_senescence | 0.72811422 |
| 102 | MP0005408_hypopigmentation | 0.72627308 |
| 103 | MP0003763_abnormal_thymus_physiology | 0.71941276 |
| 104 | MP0001243_abnormal_dermal_layer | 0.71438792 |
| 105 | MP0005174_abnormal_tail_pigmentation | 0.70267555 |
| 106 | MP0010307_abnormal_tumor_latency | 0.69092129 |
| 107 | MP0005394_taste/olfaction_phenotype | 0.68402792 |
| 108 | MP0005499_abnormal_olfactory_system | 0.68402792 |
| 109 | MP0001929_abnormal_gametogenesis | 0.68402608 |
| 110 | MP0003937_abnormal_limbs/digits/tail_de | 0.68357356 |
| 111 | MP0002398_abnormal_bone_marrow | 0.67423887 |
| 112 | MP0000703_abnormal_thymus_morphology | 0.67179103 |
| 113 | MP0009672_abnormal_birth_weight | 0.66867336 |
| 114 | MP0001286_abnormal_eye_development | 0.66744900 |
| 115 | MP0003136_yellow_coat_color | 0.65601581 |
| 116 | MP0002932_abnormal_joint_morphology | 0.65541183 |
| 117 | MP0002161_abnormal_fertility/fecundity | 0.64331623 |
| 118 | MP0001764_abnormal_homeostasis | 0.64037240 |
| 119 | MP0003656_abnormal_erythrocyte_physiolo | 0.63762471 |
| 120 | MP0005389_reproductive_system_phenotype | 0.63490046 |
| 121 | MP0000383_abnormal_hair_follicle | 0.62357106 |
| 122 | MP0003936_abnormal_reproductive_system | 0.60687691 |
| 123 | MP0002429_abnormal_blood_cell | 0.59329510 |
| 124 | MP0001881_abnormal_mammary_gland | 0.58279678 |
| 125 | MP0003137_abnormal_impulse_conducting | 0.55680997 |
| 126 | MP0002269_muscular_atrophy | 0.54331108 |
| 127 | MP0001186_pigmentation_phenotype | 0.53684595 |
| 128 | MP0005621_abnormal_cell_physiology | 0.50410658 |
| 129 | MP0002075_abnormal_coat/hair_pigmentati | 0.49930994 |
| 130 | MP0002177_abnormal_outer_ear | 0.49031121 |
| 131 | MP0003699_abnormal_female_reproductive | 0.48859363 |
| 132 | MP0005083_abnormal_biliary_tract | 0.48851819 |
| 133 | MP0002249_abnormal_larynx_morphology | 0.47519640 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.27163869 |
| 2 | Reticulocytopenia (HP:0001896) | 5.24660007 |
| 3 | Abnormal number of erythroid precursors (HP:0012131) | 5.08284383 |
| 4 | Birth length less than 3rd percentile (HP:0003561) | 4.42698344 |
| 5 | Progressive macrocephaly (HP:0004481) | 4.12387616 |
| 6 | Carpal bone hypoplasia (HP:0001498) | 3.63806308 |
| 7 | Oral leukoplakia (HP:0002745) | 3.63790035 |
| 8 | Breast hypoplasia (HP:0003187) | 3.56186353 |
| 9 | Increased intramyocellular lipid droplets (HP:0012240) | 3.54294435 |
| 10 | Macrocytic anemia (HP:0001972) | 3.45720932 |
| 11 | Cerebral edema (HP:0002181) | 3.44326868 |
| 12 | Lactic acidosis (HP:0003128) | 3.40949754 |
| 13 | Abnormality of the anterior horn cell (HP:0006802) | 3.33731767 |
| 14 | Degeneration of anterior horn cells (HP:0002398) | 3.33731767 |
| 15 | Selective tooth agenesis (HP:0001592) | 3.29525305 |
| 16 | Aplastic anemia (HP:0001915) | 3.23840980 |
| 17 | Pallor (HP:0000980) | 3.20636742 |
| 18 | Patellar aplasia (HP:0006443) | 3.15089036 |
| 19 | Exercise intolerance (HP:0003546) | 3.12952604 |
| 20 | Cholecystitis (HP:0001082) | 3.09810736 |
| 21 | Abnormal gallbladder physiology (HP:0012438) | 3.09810736 |
| 22 | Increased muscle lipid content (HP:0009058) | 3.05434428 |
| 23 | 11 pairs of ribs (HP:0000878) | 3.03679383 |
| 24 | Respiratory failure (HP:0002878) | 2.97902143 |
| 25 | Renal Fanconi syndrome (HP:0001994) | 2.95253494 |
| 26 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.91618463 |
| 27 | Colon cancer (HP:0003003) | 2.91133142 |
| 28 | Abnormality of glycolysis (HP:0004366) | 2.80612959 |
| 29 | Increased serum pyruvate (HP:0003542) | 2.80612959 |
| 30 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.76981836 |
| 31 | Rough bone trabeculation (HP:0100670) | 2.76130625 |
| 32 | Ragged-red muscle fibers (HP:0003200) | 2.71623968 |
| 33 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.69189336 |
| 34 | Premature graying of hair (HP:0002216) | 2.57200894 |
| 35 | Multiple enchondromatosis (HP:0005701) | 2.54675996 |
| 36 | Absent thumb (HP:0009777) | 2.51603659 |
| 37 | Progressive microcephaly (HP:0000253) | 2.50891840 |
| 38 | Progressive muscle weakness (HP:0003323) | 2.48880828 |
| 39 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.48140552 |
| 40 | Microretrognathia (HP:0000308) | 2.47679999 |
| 41 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.47501414 |
| 42 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.47501414 |
| 43 | Abnormal protein glycosylation (HP:0012346) | 2.47501414 |
| 44 | Abnormal glycosylation (HP:0012345) | 2.47501414 |
| 45 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.46357533 |
| 46 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.46357533 |
| 47 | Respiratory difficulties (HP:0002880) | 2.45487967 |
| 48 | Trismus (HP:0000211) | 2.43674313 |
| 49 | Testicular atrophy (HP:0000029) | 2.42903306 |
| 50 | Secondary amenorrhea (HP:0000869) | 2.41402228 |
| 51 | Type I transferrin isoform profile (HP:0003642) | 2.41109911 |
| 52 | Emotional lability (HP:0000712) | 2.40193097 |
| 53 | 3-Methylglutaconic aciduria (HP:0003535) | 2.39709007 |
| 54 | Hepatocellular necrosis (HP:0001404) | 2.39516447 |
| 55 | Increased CSF lactate (HP:0002490) | 2.36762432 |
| 56 | Leukodystrophy (HP:0002415) | 2.35232584 |
| 57 | Chromsome breakage (HP:0040012) | 2.32981356 |
| 58 | Increased serum lactate (HP:0002151) | 2.31544218 |
| 59 | Abnormality of the preputium (HP:0100587) | 2.29888797 |
| 60 | Mitochondrial inheritance (HP:0001427) | 2.29840937 |
| 61 | Sparse eyelashes (HP:0000653) | 2.28652059 |
| 62 | Abnormal lung lobation (HP:0002101) | 2.27353108 |
| 63 | Horseshoe kidney (HP:0000085) | 2.27094445 |
| 64 | CNS demyelination (HP:0007305) | 2.26194524 |
| 65 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.26078793 |
| 66 | Hepatic necrosis (HP:0002605) | 2.25648766 |
| 67 | Meckel diverticulum (HP:0002245) | 2.25540183 |
| 68 | Glossoptosis (HP:0000162) | 2.25227992 |
| 69 | Acute necrotizing encephalopathy (HP:0006965) | 2.23715546 |
| 70 | Abnormality of the ileum (HP:0001549) | 2.20612114 |
| 71 | Increased hepatocellular lipid droplets (HP:0006565) | 2.18142773 |
| 72 | Cerebral hypomyelination (HP:0006808) | 2.18098618 |
| 73 | Absent radius (HP:0003974) | 2.17272042 |
| 74 | Atresia of the external auditory canal (HP:0000413) | 2.16972725 |
| 75 | Triphalangeal thumb (HP:0001199) | 2.16494374 |
| 76 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 2.13405483 |
| 77 | Thrombocytosis (HP:0001894) | 2.12395120 |
| 78 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.12244249 |
| 79 | Irregular epiphyses (HP:0010582) | 2.07655977 |
| 80 | Aplasia involving forearm bones (HP:0009822) | 2.04137484 |
| 81 | Absent forearm bone (HP:0003953) | 2.04137484 |
| 82 | Cellular immunodeficiency (HP:0005374) | 2.02842155 |
| 83 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.01720888 |
| 84 | Abnormal trabecular bone morphology (HP:0100671) | 2.01667922 |
| 85 | Abnormality of the umbilical cord (HP:0010881) | 2.01341314 |
| 86 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.99471112 |
| 87 | Optic disc pallor (HP:0000543) | 1.98562145 |
| 88 | Delusions (HP:0000746) | 1.97653090 |
| 89 | Myelodysplasia (HP:0002863) | 1.96461217 |
| 90 | Ependymoma (HP:0002888) | 1.95368717 |
| 91 | Missing ribs (HP:0000921) | 1.95001564 |
| 92 | Lethargy (HP:0001254) | 1.93982806 |
| 93 | Microvesicular hepatic steatosis (HP:0001414) | 1.93232256 |
| 94 | Cleft eyelid (HP:0000625) | 1.91913992 |
| 95 | Lipid accumulation in hepatocytes (HP:0006561) | 1.91843378 |
| 96 | Abnormality of chromosome stability (HP:0003220) | 1.90134940 |
| 97 | Hypoplasia of the radius (HP:0002984) | 1.89709057 |
| 98 | Neoplasm of the adrenal gland (HP:0100631) | 1.89514541 |
| 99 | Redundant skin (HP:0001582) | 1.88796356 |
| 100 | Stenosis of the external auditory canal (HP:0000402) | 1.88767340 |
| 101 | Abnormality of the labia minora (HP:0012880) | 1.86779483 |
| 102 | Facial cleft (HP:0002006) | 1.86301207 |
| 103 | Slender long bone (HP:0003100) | 1.86093119 |
| 104 | Neoplasm of the pancreas (HP:0002894) | 1.84393954 |
| 105 | Hypokinesia (HP:0002375) | 1.83209908 |
| 106 | Pancytopenia (HP:0001876) | 1.82957423 |
| 107 | Premature ovarian failure (HP:0008209) | 1.82072836 |
| 108 | Unsteady gait (HP:0002317) | 1.81676712 |
| 109 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.80388929 |
| 110 | X-linked dominant inheritance (HP:0001423) | 1.80354019 |
| 111 | Squamous cell carcinoma (HP:0002860) | 1.79846893 |
| 112 | Small intestinal stenosis (HP:0012848) | 1.78992696 |
| 113 | Duodenal stenosis (HP:0100867) | 1.78992696 |
| 114 | Facial hemangioma (HP:0000329) | 1.77954668 |
| 115 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.77778564 |
| 116 | Increased nuchal translucency (HP:0010880) | 1.77660529 |
| 117 | Acute encephalopathy (HP:0006846) | 1.77491974 |
| 118 | Bone marrow hypocellularity (HP:0005528) | 1.76971844 |
| 119 | Abnormality of reticulocytes (HP:0004312) | 1.76955933 |
| 120 | Muscle fiber atrophy (HP:0100295) | 1.75976031 |
| 121 | Optic nerve coloboma (HP:0000588) | 1.75770700 |
| 122 | Biconcave vertebral bodies (HP:0004586) | 1.75534548 |
| 123 | Pulmonary fibrosis (HP:0002206) | 1.75377566 |
| 124 | Hyperalaninemia (HP:0003348) | 1.74750557 |
| 125 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.74750557 |
| 126 | Abnormality of alanine metabolism (HP:0010916) | 1.74750557 |
| 127 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 1.74436725 |
| 128 | Exertional dyspnea (HP:0002875) | 1.73415955 |
| 129 | Gonadal dysgenesis (HP:0000133) | 1.69588889 |
| 130 | Congenital, generalized hypertrichosis (HP:0004540) | 1.69279345 |
| 131 | Gliosis (HP:0002171) | 1.68867619 |
| 132 | Postnatal microcephaly (HP:0005484) | 1.68363221 |
| 133 | Wide cranial sutures (HP:0010537) | 1.68278554 |
| 134 | Abnormal number of incisors (HP:0011064) | 1.67697601 |
| 135 | Rectal fistula (HP:0100590) | 1.67479131 |
| 136 | Rectovaginal fistula (HP:0000143) | 1.67479131 |
| 137 | Medulloblastoma (HP:0002885) | 1.64675399 |
| 138 | Supernumerary spleens (HP:0009799) | 1.64203277 |
| 139 | Reduced antithrombin III activity (HP:0001976) | 1.63434024 |
| 140 | Depressed nasal ridge (HP:0000457) | 1.63114034 |
| 141 | Tracheoesophageal fistula (HP:0002575) | 1.62872075 |
| 142 | Aplasia/hypoplasia of the humerus (HP:0006507) | 1.62418761 |
| 143 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.62223523 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 6.43662487 |
| 2 | BUB1 | 4.65127786 |
| 3 | WEE1 | 4.22204927 |
| 4 | EIF2AK1 | 3.78313840 |
| 5 | CDC7 | 3.42364654 |
| 6 | SRPK1 | 2.82203410 |
| 7 | VRK1 | 2.74116746 |
| 8 | NME2 | 2.72602805 |
| 9 | STK16 | 2.67043525 |
| 10 | SMG1 | 2.41955644 |
| 11 | ACVR1B | 2.40122921 |
| 12 | EIF2AK3 | 2.14243278 |
| 13 | TESK2 | 2.11140291 |
| 14 | PIM2 | 2.04423952 |
| 15 | BRSK2 | 1.78089543 |
| 16 | PDK2 | 1.75793065 |
| 17 | PLK1 | 1.74521645 |
| 18 | CDK7 | 1.74483815 |
| 19 | PLK4 | 1.72490988 |
| 20 | NEK2 | 1.66433345 |
| 21 | RPS6KB2 | 1.63147839 |
| 22 | TTK | 1.60153926 |
| 23 | TLK1 | 1.57953907 |
| 24 | TAF1 | 1.56943898 |
| 25 | AURKB | 1.56348252 |
| 26 | PASK | 1.54071910 |
| 27 | TGFBR1 | 1.53086554 |
| 28 | TESK1 | 1.50045238 |
| 29 | ATR | 1.47078568 |
| 30 | MKNK1 | 1.41225871 |
| 31 | TSSK6 | 1.38479516 |
| 32 | CCNB1 | 1.37541037 |
| 33 | NEK1 | 1.35988517 |
| 34 | DYRK2 | 1.34344137 |
| 35 | BCKDK | 1.34064896 |
| 36 | AURKA | 1.32401694 |
| 37 | STK10 | 1.31897739 |
| 38 | PLK3 | 1.28344973 |
| 39 | EIF2AK2 | 1.27252823 |
| 40 | BRSK1 | 1.26966569 |
| 41 | MAP3K12 | 1.21745543 |
| 42 | IRAK3 | 1.17839897 |
| 43 | RPS6KA4 | 1.15479279 |
| 44 | PAK4 | 1.14518392 |
| 45 | DYRK3 | 1.11573290 |
| 46 | MAPKAPK3 | 1.08852293 |
| 47 | TRIM28 | 1.06626189 |
| 48 | CHEK2 | 1.05754068 |
| 49 | TAOK2 | 1.02998685 |
| 50 | SCYL2 | 1.01548165 |
| 51 | CSNK1G1 | 1.00613664 |
| 52 | KDR | 1.00266133 |
| 53 | MAP3K8 | 0.99014707 |
| 54 | CDK8 | 0.98870283 |
| 55 | EPHA2 | 0.98719395 |
| 56 | CSNK1A1L | 0.97877677 |
| 57 | STK38L | 0.95844230 |
| 58 | LIMK1 | 0.94808679 |
| 59 | PBK | 0.93491720 |
| 60 | MAP3K11 | 0.90218818 |
| 61 | ZAK | 0.89961529 |
| 62 | CSNK1G2 | 0.87257906 |
| 63 | CHEK1 | 0.84113406 |
| 64 | LRRK2 | 0.82039401 |
| 65 | PAK1 | 0.81484164 |
| 66 | FLT3 | 0.80707486 |
| 67 | PIM1 | 0.79824734 |
| 68 | NME1 | 0.79206619 |
| 69 | MUSK | 0.78980734 |
| 70 | CSNK2A1 | 0.77807688 |
| 71 | CDK4 | 0.74573571 |
| 72 | ERBB3 | 0.73606050 |
| 73 | MST4 | 0.73062218 |
| 74 | ILK | 0.72576562 |
| 75 | CSNK2A2 | 0.68250169 |
| 76 | BRAF | 0.67204163 |
| 77 | STK24 | 0.65745228 |
| 78 | TEC | 0.65434522 |
| 79 | ATM | 0.64162724 |
| 80 | CDK2 | 0.58979353 |
| 81 | RPS6KA5 | 0.56949767 |
| 82 | CLK1 | 0.56395954 |
| 83 | MAP4K1 | 0.55372067 |
| 84 | PRKCI | 0.54340985 |
| 85 | CDK1 | 0.51488676 |
| 86 | PIK3CG | 0.51268102 |
| 87 | MAP2K6 | 0.50064939 |
| 88 | GRK5 | 0.49933364 |
| 89 | MELK | 0.48148155 |
| 90 | MAPKAPK5 | 0.47433404 |
| 91 | CDK12 | 0.43623145 |
| 92 | YES1 | 0.43184326 |
| 93 | STK4 | 0.42967985 |
| 94 | MAP2K3 | 0.42094157 |
| 95 | PRKD3 | 0.41551126 |
| 96 | CSNK1G3 | 0.40242032 |
| 97 | DYRK1B | 0.39248367 |
| 98 | CDK11A | 0.39178910 |
| 99 | MKNK2 | 0.38776121 |
| 100 | KIT | 0.37674579 |
| 101 | CDK18 | 0.36972336 |
| 102 | CDK15 | 0.36641096 |
| 103 | MAP3K3 | 0.36370883 |
| 104 | CDK14 | 0.36190554 |
| 105 | ALK | 0.34266764 |
| 106 | PAK2 | 0.33360133 |
| 107 | CSF1R | 0.33156920 |
| 108 | AKT2 | 0.31308294 |
| 109 | LATS2 | 0.28674573 |
| 110 | DAPK1 | 0.28597382 |
| 111 | MAP2K2 | 0.28460490 |
| 112 | ABL2 | 0.28404221 |
| 113 | ADRBK2 | 0.28010860 |
| 114 | MYLK | 0.27940818 |
| 115 | DAPK3 | 0.27369678 |
| 116 | MARK3 | 0.27251621 |
| 117 | EEF2K | 0.27117858 |
| 118 | MATK | 0.27038960 |
| 119 | BTK | 0.26251695 |
| 120 | TXK | 0.26088532 |
| 121 | IKBKB | 0.25870274 |
| 122 | NUAK1 | 0.25517080 |
| 123 | MAPK4 | 0.24112440 |
| 124 | MINK1 | 0.23645732 |
| 125 | CSNK1E | 0.19261368 |
| 126 | PRKDC | 0.18340515 |
| 127 | MST1R | 0.17188854 |
| 128 | CDK9 | 0.15607927 |
| 129 | CDK19 | 0.15494053 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.82180557 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 4.60096924 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 3.88537940 |
| 4 | Proteasome_Homo sapiens_hsa03050 | 3.87786318 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 3.27007020 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.23112040 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 3.12290944 |
| 8 | Base excision repair_Homo sapiens_hsa03410 | 3.11319231 |
| 9 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.88068369 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.75191206 |
| 11 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.72750806 |
| 12 | RNA transport_Homo sapiens_hsa03013 | 2.64773054 |
| 13 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.50970990 |
| 14 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.22569942 |
| 15 | Cell cycle_Homo sapiens_hsa04110 | 2.20365292 |
| 16 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.77291700 |
| 17 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.65869520 |
| 18 | RNA degradation_Homo sapiens_hsa03018 | 1.61468138 |
| 19 | Basal transcription factors_Homo sapiens_hsa03022 | 1.56545553 |
| 20 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.47097419 |
| 21 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.45457979 |
| 22 | Protein export_Homo sapiens_hsa03060 | 1.42265106 |
| 23 | Purine metabolism_Homo sapiens_hsa00230 | 1.41957837 |
| 24 | Parkinsons disease_Homo sapiens_hsa05012 | 1.36770000 |
| 25 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.21828704 |
| 26 | Huntingtons disease_Homo sapiens_hsa05016 | 1.16818782 |
| 27 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.10873585 |
| 28 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.08634908 |
| 29 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.05137049 |
| 30 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.02760186 |
| 31 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.01495757 |
| 32 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.98286143 |
| 33 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.98178965 |
| 34 | Sulfur relay system_Homo sapiens_hsa04122 | 0.96504287 |
| 35 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.94754799 |
| 36 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.88624352 |
| 37 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.87495144 |
| 38 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.86968022 |
| 39 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.85369635 |
| 40 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.85090785 |
| 41 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.81506142 |
| 42 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.74525358 |
| 43 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.74210417 |
| 44 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.73681137 |
| 45 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.71439408 |
| 46 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.71279133 |
| 47 | Carbon metabolism_Homo sapiens_hsa01200 | 0.67983928 |
| 48 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.66439297 |
| 49 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.64958367 |
| 50 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.64630426 |
| 51 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.63835661 |
| 52 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.63389824 |
| 53 | Alzheimers disease_Homo sapiens_hsa05010 | 0.61223315 |
| 54 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.60847366 |
| 55 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.60181025 |
| 56 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.59556978 |
| 57 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.59296666 |
| 58 | HTLV-I infection_Homo sapiens_hsa05166 | 0.56008722 |
| 59 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.52875911 |
| 60 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.52822489 |
| 61 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.51743072 |
| 62 | Thyroid cancer_Homo sapiens_hsa05216 | 0.51701486 |
| 63 | Legionellosis_Homo sapiens_hsa05134 | 0.50554890 |
| 64 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.49859137 |
| 65 | Metabolic pathways_Homo sapiens_hsa01100 | 0.47886273 |
| 66 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.47377645 |
| 67 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.46159246 |
| 68 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.45291308 |
| 69 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.44844172 |
| 70 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.44089702 |
| 71 | Galactose metabolism_Homo sapiens_hsa00052 | 0.44002221 |
| 72 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.39017876 |
| 73 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.38300409 |
| 74 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.36116184 |
| 75 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.35853158 |
| 76 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.35305700 |
| 77 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.34623019 |
| 78 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.33623416 |
| 79 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.33490041 |
| 80 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.31642945 |
| 81 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.31344681 |
| 82 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.30378863 |
| 83 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.30050062 |
| 84 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.28633726 |
| 85 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.24298634 |
| 86 | Apoptosis_Homo sapiens_hsa04210 | 0.24018000 |
| 87 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.21892426 |
| 88 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.21406209 |
| 89 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.21318667 |
| 90 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.20086764 |
| 91 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.19848086 |
| 92 | Bladder cancer_Homo sapiens_hsa05219 | 0.18567346 |
| 93 | Viral myocarditis_Homo sapiens_hsa05416 | 0.18404906 |
| 94 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.17575197 |
| 95 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.16943611 |
| 96 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.16812052 |
| 97 | Alcoholism_Homo sapiens_hsa05034 | 0.16373407 |
| 98 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.15970160 |
| 99 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.15069246 |
| 100 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.14186711 |
| 101 | Retinol metabolism_Homo sapiens_hsa00830 | 0.14082637 |
| 102 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.13578204 |
| 103 | Peroxisome_Homo sapiens_hsa04146 | 0.13232539 |
| 104 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.13026930 |
| 105 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.12568351 |
| 106 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.12454029 |
| 107 | Shigellosis_Homo sapiens_hsa05131 | 0.10856467 |
| 108 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.10390934 |
| 109 | Measles_Homo sapiens_hsa05162 | 0.10200029 |
| 110 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.08851152 |
| 111 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.08566250 |
| 112 | Colorectal cancer_Homo sapiens_hsa05210 | 0.08113348 |
| 113 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.08009440 |
| 114 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.07679491 |
| 115 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.06894164 |
| 116 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.06416032 |
| 117 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.04264075 |
| 118 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.02916187 |
| 119 | Lysine degradation_Homo sapiens_hsa00310 | 0.01573916 |
| 120 | Fatty acid degradation_Homo sapiens_hsa00071 | -0.0469804 |
| 121 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | -0.0372312 |
| 122 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | -0.0130392 |

