HAUS8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: HAUS8 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1superoxide anion generation (GO:0042554)4.83099737
2kinetochore assembly (GO:0051382)4.16951956
3kinetochore organization (GO:0051383)3.98829266
4negative regulation of DNA-dependent DNA replication (GO:2000104)3.77087205
5somatic hypermutation of immunoglobulin genes (GO:0016446)3.69204449
6somatic diversification of immune receptors via somatic mutation (GO:0002566)3.69204449
7protein localization to kinetochore (GO:0034501)3.57905058
8recombinational repair (GO:0000725)3.56888369
9DNA integration (GO:0015074)3.53072493
10piRNA metabolic process (GO:0034587)3.52942291
11pseudouridine synthesis (GO:0001522)3.52522306
12double-strand break repair via homologous recombination (GO:0000724)3.50534281
13meiotic chromosome segregation (GO:0045132)3.46864410
14CENP-A containing nucleosome assembly (GO:0034080)3.46383069
15DNA deamination (GO:0045006)3.43760685
16mitotic sister chromatid segregation (GO:0000070)3.41731191
17regulation of nuclear cell cycle DNA replication (GO:0033262)3.41483774
18respiratory chain complex IV assembly (GO:0008535)3.39730017
19mitochondrial respiratory chain complex I assembly (GO:0032981)3.36912392
20NADH dehydrogenase complex assembly (GO:0010257)3.36912392
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.36912392
22protein complex biogenesis (GO:0070271)3.32417305
23DNA strand renaturation (GO:0000733)3.32193506
24telomere maintenance via semi-conservative replication (GO:0032201)3.31205325
25chromatin remodeling at centromere (GO:0031055)3.30619495
26telomere maintenance via recombination (GO:0000722)3.25810077
27centriole assembly (GO:0098534)3.25606746
28mitochondrial respiratory chain complex assembly (GO:0033108)3.25030863
29DNA replication-dependent nucleosome assembly (GO:0006335)3.17162860
30DNA replication-dependent nucleosome organization (GO:0034723)3.17162860
31cytochrome complex assembly (GO:0017004)3.16188609
32regulation of double-strand break repair via homologous recombination (GO:0010569)3.15252623
33resolution of meiotic recombination intermediates (GO:0000712)3.14747680
34nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.12749941
35negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.12118252
36exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11184369
37regulation of meiosis I (GO:0060631)3.06972339
38protein K6-linked ubiquitination (GO:0085020)3.06690572
39microtubule depolymerization (GO:0007019)3.06313549
40DNA ligation (GO:0006266)3.06004774
41proteasome assembly (GO:0043248)3.03517192
42sister chromatid segregation (GO:0000819)3.03067914
43tRNA methylation (GO:0030488)3.01894973
44maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.00679680
45DNA synthesis involved in DNA repair (GO:0000731)3.00667608
46DNA methylation involved in gamete generation (GO:0043046)2.99826394
47regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98699031
48anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.98390607
49establishment of protein localization to mitochondrial membrane (GO:0090151)2.97540124
50protein localization to chromosome, centromeric region (GO:0071459)2.97520706
51behavioral response to nicotine (GO:0035095)2.97514591
52mismatch repair (GO:0006298)2.96928345
53G-protein coupled receptor internalization (GO:0002031)2.96753835
54telomere maintenance via telomere lengthening (GO:0010833)2.96517284
55mitotic recombination (GO:0006312)2.96068460
56postreplication repair (GO:0006301)2.94507129
57DNA replication checkpoint (GO:0000076)2.94010269
58RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.93167441
59mitochondrial RNA metabolic process (GO:0000959)2.90377235
60DNA recombination (GO:0006310)2.90365527
61water-soluble vitamin biosynthetic process (GO:0042364)2.89334542
62deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.87884331
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.87396100
64intra-S DNA damage checkpoint (GO:0031573)2.86951511
65DNA catabolic process, exonucleolytic (GO:0000738)2.84194128
66attachment of spindle microtubules to kinetochore (GO:0008608)2.83783804
67translesion synthesis (GO:0019985)2.83370204
68mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.82909901
69DNA strand elongation involved in DNA replication (GO:0006271)2.82860316
70negative regulation of mast cell activation (GO:0033004)2.82379185
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.81276532
72negative regulation of ligase activity (GO:0051352)2.81276532
73spindle checkpoint (GO:0031577)2.81039959
74double-strand break repair (GO:0006302)2.80874319
75DNA strand elongation (GO:0022616)2.79707624
76protein-cofactor linkage (GO:0018065)2.78540552
77rRNA modification (GO:0000154)2.78474597
78somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.78290643
79isotype switching (GO:0045190)2.78290643
80somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.78290643
81spliceosomal snRNP assembly (GO:0000387)2.77805966
82regulation of DNA endoreduplication (GO:0032875)2.77551103
83regulation of centriole replication (GO:0046599)2.76591564
84superoxide metabolic process (GO:0006801)2.74178142
85doxorubicin metabolic process (GO:0044598)2.73508407
86daunorubicin metabolic process (GO:0044597)2.73508407
87polyketide metabolic process (GO:0030638)2.73508407
88RNA-dependent DNA replication (GO:0006278)2.72479751
89regulation of activation of Janus kinase activity (GO:0010533)2.72465982
90DNA double-strand break processing (GO:0000729)2.70372567
91response to pheromone (GO:0019236)2.70212551
92regulation of mitotic spindle checkpoint (GO:1903504)2.70016061
93regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.70016061
94DNA replication initiation (GO:0006270)2.69272221
95male meiosis I (GO:0007141)2.68492786
96maturation of 5.8S rRNA (GO:0000460)2.67527725
97nucleobase biosynthetic process (GO:0046112)2.66452961
98deoxyribonucleotide biosynthetic process (GO:0009263)2.64920075
99termination of RNA polymerase III transcription (GO:0006386)2.63776691
100transcription elongation from RNA polymerase III promoter (GO:0006385)2.63776691
101DNA replication-independent nucleosome assembly (GO:0006336)2.60860217
102DNA replication-independent nucleosome organization (GO:0034724)2.60860217
103centriole replication (GO:0007099)2.58535769
104replication fork processing (GO:0031297)2.58144409
105female gonad development (GO:0008585)2.58076302
106nucleotide-excision repair, DNA gap filling (GO:0006297)2.57103938
107response to peptidoglycan (GO:0032494)2.56642432
108transcription elongation from RNA polymerase I promoter (GO:0006362)2.55847887
109ribosomal large subunit biogenesis (GO:0042273)2.55490556
110termination of RNA polymerase I transcription (GO:0006363)2.55242620
111rRNA methylation (GO:0031167)2.54652679
112amino sugar catabolic process (GO:0046348)2.53256081
113telomere maintenance via telomerase (GO:0007004)2.52638466
114reciprocal meiotic recombination (GO:0007131)2.52629297
115reciprocal DNA recombination (GO:0035825)2.52629297
116protein heterotetramerization (GO:0051290)2.52131119
117telomere maintenance (GO:0000723)2.51815729
118regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.49617446
119dendritic cell chemotaxis (GO:0002407)2.49480489
120telomere organization (GO:0032200)2.49300964
121histone exchange (GO:0043486)2.44960518
122RNA methylation (GO:0001510)2.44326716
123deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.43616873
124pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.43348985
125positive regulation of DNA-dependent DNA replication (GO:2000105)2.43310191
126dendritic cell migration (GO:0036336)2.41240325
127mitotic metaphase plate congression (GO:0007080)2.39885084
128replicative senescence (GO:0090399)2.38543809
129regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.38351657
130DNA-dependent DNA replication (GO:0006261)2.38172729
131neutrophil activation involved in immune response (GO:0002283)2.37771621
132response to X-ray (GO:0010165)2.37511163
133cell proliferation in forebrain (GO:0021846)2.35545064
134energy homeostasis (GO:0097009)2.34370993
135transcription-coupled nucleotide-excision repair (GO:0006283)2.33351701
136negative regulation of telomere maintenance (GO:0032205)2.33166595
137transcription from RNA polymerase I promoter (GO:0006360)2.32867151
138mesenchymal cell differentiation involved in renal system development (GO:2001012)2.32791093
139mesenchymal cell differentiation involved in kidney development (GO:0072161)2.32791093
140positive regulation of interleukin-1 beta secretion (GO:0050718)2.32174521
141positive regulation of protein homodimerization activity (GO:0090073)2.31456190
142RNA capping (GO:0036260)2.30141510
1437-methylguanosine RNA capping (GO:0009452)2.30141510
144RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.29266399
145tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.29266399
146synapsis (GO:0007129)2.27845567
147neutrophil activation (GO:0042119)2.26984355
148tRNA modification (GO:0006400)2.26796131
1497-methylguanosine mRNA capping (GO:0006370)2.23622740
150metaphase plate congression (GO:0051310)2.23028146
151regulation of DNA-dependent DNA replication (GO:0090329)2.21026777
152lymphoid progenitor cell differentiation (GO:0002320)2.21016852
153tRNA processing (GO:0008033)2.20278317

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.61109191
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.40688730
3PCGF2_27294783_Chip-Seq_ESCs_Mouse2.93931418
4MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.91579863
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.87487931
6ZNF274_21170338_ChIP-Seq_K562_Hela2.68347994
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.67558341
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.66293821
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66030865
10PCGF2_27294783_Chip-Seq_NPCs_Mouse2.41898248
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.34616484
12SUZ12_27294783_Chip-Seq_NPCs_Mouse2.34388290
13NFE2_27457419_Chip-Seq_LIVER_Mouse2.34055726
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.22571054
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18138594
16* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17532939
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.15588392
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.11639586
19GBX2_23144817_ChIP-Seq_PC3_Human2.05881064
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.03595658
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00121995
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96380025
23EZH2_27294783_Chip-Seq_NPCs_Mouse1.92584695
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89197781
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.88446305
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87135395
27GABP_19822575_ChIP-Seq_HepG2_Human1.78444800
28STAT3_18555785_Chip-Seq_ESCs_Mouse1.78351037
29* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77861302
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77232089
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.76702606
32NMYC_18555785_Chip-Seq_ESCs_Mouse1.72775177
33EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.72599155
34SUZ12_18555785_Chip-Seq_ESCs_Mouse1.72173676
35DCP1A_22483619_ChIP-Seq_HELA_Human1.71825476
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69666723
37E2F1_18555785_Chip-Seq_ESCs_Mouse1.68696625
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.66357127
39EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.66330295
40P53_22387025_ChIP-Seq_ESCs_Mouse1.65476768
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.62875012
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61631625
43ELK1_19687146_ChIP-ChIP_HELA_Human1.61159151
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.60839409
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60671004
46P300_18555785_Chip-Seq_ESCs_Mouse1.58664796
47EWS_26573619_Chip-Seq_HEK293_Human1.58220185
48NANOG_18555785_Chip-Seq_ESCs_Mouse1.57898323
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57525023
50ZFX_18555785_Chip-Seq_ESCs_Mouse1.55964144
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.55405134
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.54863140
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.54843371
54IRF1_19129219_ChIP-ChIP_H3396_Human1.54050355
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53166925
56RUNX1_27457419_Chip-Seq_LIVER_Mouse1.52244121
57OCT4_18555785_Chip-Seq_ESCs_Mouse1.51224523
58CMYC_18555785_Chip-Seq_ESCs_Mouse1.47040289
59KLF4_18555785_Chip-Seq_ESCs_Mouse1.46420977
60SOX2_18555785_Chip-Seq_ESCs_Mouse1.46043007
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.44916248
62PU1_27457419_Chip-Seq_LIVER_Mouse1.44662059
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43506511
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42415193
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.40966917
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40519628
67IGF1R_20145208_ChIP-Seq_DFB_Human1.40135770
68XRN2_22483619_ChIP-Seq_HELA_Human1.39893321
69MYC_18555785_ChIP-Seq_MESCs_Mouse1.39716595
70FUS_26573619_Chip-Seq_HEK293_Human1.38207353
71KDM5A_27292631_Chip-Seq_BREAST_Human1.37665068
72ESRRB_18555785_Chip-Seq_ESCs_Mouse1.36984492
73SMAD1_18555785_Chip-Seq_ESCs_Mouse1.36642411
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36586840
75IRF8_22096565_ChIP-ChIP_GC-B_Human1.36439076
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33843762
77CTCF_18555785_Chip-Seq_ESCs_Mouse1.33517288
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.33183432
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.31132361
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30658866
81NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29663414
82FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.27490993
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.27342863
84VDR_23849224_ChIP-Seq_CD4+_Human1.23869719
85CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23469526
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22215286
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21419549
88MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18841096
89CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17126237
90OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17070572
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16844657
92TP53_22573176_ChIP-Seq_HFKS_Human1.15959433
93* CBX2_27304074_Chip-Seq_ESCs_Mouse1.14954081
94ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12761033
95RNF2_27304074_Chip-Seq_NSC_Mouse1.12217684
96MYC_18940864_ChIP-ChIP_HL60_Human1.11446997
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10609736
98TAL1_26923725_Chip-Seq_HPCs_Mouse1.10301078
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08823374
100E2F1_21310950_ChIP-Seq_MCF-7_Human1.08249189
101* FOXP3_21729870_ChIP-Seq_TREG_Human1.08133944
102KAP1_22055183_ChIP-Seq_ESCs_Mouse1.08085908
103VDR_22108803_ChIP-Seq_LS180_Human1.06511180
104P300_19829295_ChIP-Seq_ESCs_Human1.06494306
105FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05966274
106ER_23166858_ChIP-Seq_MCF-7_Human1.04858522
107YY1_21170310_ChIP-Seq_MESCs_Mouse1.03780167
108MYC_19030024_ChIP-ChIP_MESCs_Mouse1.03733488
109CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03150957
110ETS1_20019798_ChIP-Seq_JURKAT_Human1.02783708
111CIITA_25753668_ChIP-Seq_RAJI_Human0.99958216
112POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99869235
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99821719
114HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99310476
115HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99152232
116SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98087095
117MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97304261
118* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96475100
119EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96181758
120* TTF2_22483619_ChIP-Seq_HELA_Human0.94009570
121ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90645871
122FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90222965
123FOXA1_25329375_ChIP-Seq_VCAP_Human0.90222965
124CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90220981
125MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89557383
126AR_21909140_ChIP-Seq_LNCAP_Human0.89057636
127STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88205151
128MYC_19079543_ChIP-ChIP_MESCs_Mouse0.87719165
129YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87234936
130SPI1_23547873_ChIP-Seq_NB4_Human0.87106780
131KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.85045610
132ELK1_22589737_ChIP-Seq_MCF10A_Human0.84929515
133SOX2_16153702_ChIP-ChIP_HESCs_Human0.82270874
134HOXB7_26014856_ChIP-Seq_BT474_Human0.82236621
135NANOG_18555785_ChIP-Seq_MESCs_Mouse0.81960167
136DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81390129
137NCOR_22424771_ChIP-Seq_293T_Human0.80480229
138GATA3_21878914_ChIP-Seq_MCF-7_Human0.80403011
139CTBP2_25329375_ChIP-Seq_LNCAP_Human0.79992740
140AR_20517297_ChIP-Seq_VCAP_Human0.78148909
141* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77365811
142CBP_20019798_ChIP-Seq_JUKART_Human0.77080156
143IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.77080156
144HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.74081600
145PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.73008178
146BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.71754057

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation3.66404980
2MP0006292_abnormal_olfactory_placode3.45508366
3MP0008057_abnormal_DNA_replication3.25418541
4MP0008058_abnormal_DNA_repair3.17373724
5MP0003136_yellow_coat_color3.00951245
6MP0010094_abnormal_chromosome_stability2.85990018
7MP0003693_abnormal_embryo_hatching2.67660997
8MP0002102_abnormal_ear_morphology2.65986385
9MP0003111_abnormal_nucleus_morphology2.57682477
10MP0000015_abnormal_ear_pigmentation2.50677101
11MP0000566_synostosis2.47905831
12MP0002277_abnormal_respiratory_mucosa2.46556683
13MP0005174_abnormal_tail_pigmentation2.23400258
14MP0003941_abnormal_skin_development2.11324564
15MP0003806_abnormal_nucleotide_metabolis2.08039760
16MP0001835_abnormal_antigen_presentation2.06019429
17MP0004147_increased_porphyrin_level1.91697763
18MP0004381_abnormal_hair_follicle1.91629481
19MP0002163_abnormal_gland_morphology1.90053963
20MP0001986_abnormal_taste_sensitivity1.89784268
21MP0005171_absent_coat_pigmentation1.88829674
22MP0003077_abnormal_cell_cycle1.81680666
23MP0003646_muscle_fatigue1.81139761
24MP0002736_abnormal_nociception_after1.80433851
25MP0002148_abnormal_hypersensitivity_rea1.76077999
26MP0006072_abnormal_retinal_apoptosis1.69950963
27MP0001929_abnormal_gametogenesis1.68071885
28MP0002837_dystrophic_cardiac_calcinosis1.63008559
29MP0003195_calcinosis1.62523340
30MP0005409_darkened_coat_color1.62189297
31MP0000569_abnormal_digit_pigmentation1.61687111
32MP0008007_abnormal_cellular_replicative1.59562087
33MP0005451_abnormal_body_composition1.58253291
34MP0003786_premature_aging1.56466836
35MP0005551_abnormal_eye_electrophysiolog1.52258371
36MP0002396_abnormal_hematopoietic_system1.50390802
37MP0009785_altered_susceptibility_to1.50243881
38MP0009379_abnormal_foot_pigmentation1.50093297
39MP0005075_abnormal_melanosome_morpholog1.49356120
40MP0002132_abnormal_respiratory_system1.47908372
41MP0008932_abnormal_embryonic_tissue1.47262330
42MP0008872_abnormal_physiological_respon1.44940799
43MP0000490_abnormal_crypts_of1.44133419
44MP0002095_abnormal_skin_pigmentation1.41668963
45MP0008877_abnormal_DNA_methylation1.40948900
46MP0005671_abnormal_response_to1.39418303
47MP0003186_abnormal_redox_activity1.38914261
48MP0008260_abnormal_autophagy1.37143485
49MP0006035_abnormal_mitochondrial_morpho1.34767691
50MP0001529_abnormal_vocalization1.30884214
51MP0001968_abnormal_touch/_nociception1.30535527
52MP0002419_abnormal_innate_immunity1.30315318
53MP0001145_abnormal_male_reproductive1.29349814
54MP0000653_abnormal_sex_gland1.28241809
55MP0006036_abnormal_mitochondrial_physio1.26221213
56MP0005410_abnormal_fertilization1.26173990
57MP0002938_white_spotting1.25670548
58MP0010386_abnormal_urinary_bladder1.23630219
59MP0005253_abnormal_eye_physiology1.23538828
60MP0008789_abnormal_olfactory_epithelium1.21833472
61MP0001293_anophthalmia1.21648268
62MP0009697_abnormal_copulation1.20138224
63MP0003718_maternal_effect1.19832483
64MP0002452_abnormal_antigen_presenting1.19726944
65MP0003698_abnormal_male_reproductive1.19428293
66MP0001764_abnormal_homeostasis1.19067749
67MP0005379_endocrine/exocrine_gland_phen1.16479679
68MP0005000_abnormal_immune_tolerance1.16415037
69MP0002638_abnormal_pupillary_reflex1.15429923
70MP0000372_irregular_coat_pigmentation1.15297190
71MP0004742_abnormal_vestibular_system1.14317187
72MP0008995_early_reproductive_senescence1.14169218
73MP0002234_abnormal_pharynx_morphology1.13346579
74MP0005025_abnormal_response_to1.13315547
75MP0000427_abnormal_hair_cycle1.13134229
76MP0001800_abnormal_humoral_immune1.11115067
77MP0001790_abnormal_immune_system1.10719670
78MP0005387_immune_system_phenotype1.10719670
79MP0003763_abnormal_thymus_physiology1.08736842
80MP0002723_abnormal_immune_serum1.07643443
81MP0001819_abnormal_immune_cell1.06184992
82MP0003724_increased_susceptibility_to1.06082313
83MP0004142_abnormal_muscle_tone1.05768556
84MP0002420_abnormal_adaptive_immunity1.05320460
85MP0003950_abnormal_plasma_membrane1.05099126
86MP0005377_hearing/vestibular/ear_phenot1.04488604
87MP0003878_abnormal_ear_physiology1.04488604
88MP0003787_abnormal_imprinting1.04223567
89MP0000631_abnormal_neuroendocrine_gland1.02776289
90MP0003121_genomic_imprinting1.01765393
91MP0008875_abnormal_xenobiotic_pharmacok1.01603413
92MP0010307_abnormal_tumor_latency1.00815377
93MP0000383_abnormal_hair_follicle1.00249659
94MP0003890_abnormal_embryonic-extraembry0.99760002
95MP0002653_abnormal_ependyma_morphology0.97976684
96MP0003315_abnormal_perineum_morphology0.96937345
97MP0000026_abnormal_inner_ear0.94939159
98MP0002138_abnormal_hepatobiliary_system0.94435749
99MP0001485_abnormal_pinna_reflex0.93489958
100MP0009333_abnormal_splenocyte_physiolog0.92578132
101MP0000049_abnormal_middle_ear0.91914347
102MP0001324_abnormal_eye_pigmentation0.90814516
103MP0001119_abnormal_female_reproductive0.90780784
104MP0004782_abnormal_surfactant_physiolog0.90465251
105MP0005645_abnormal_hypothalamus_physiol0.89201586
106MP0001186_pigmentation_phenotype0.88217670
107MP0005257_abnormal_intraocular_pressure0.87829800
108MP0002210_abnormal_sex_determination0.87479407
109MP0001346_abnormal_lacrimal_gland0.87348210
110MP0001984_abnormal_olfaction0.86088910
111MP0000313_abnormal_cell_death0.84374305
112MP0004957_abnormal_blastocyst_morpholog0.83847537
113MP0001697_abnormal_embryo_size0.83140082
114MP0002405_respiratory_system_inflammati0.82633953
115MP0005395_other_phenotype0.81906243
116MP0003828_pulmonary_edema0.81517895
117MP0003938_abnormal_ear_development0.81323512
118MP0009046_muscle_twitch0.80795068
119MP0005646_abnormal_pituitary_gland0.80427125
120MP0005084_abnormal_gallbladder_morpholo0.79618045
121MP0002398_abnormal_bone_marrow0.79349649
122MP0000358_abnormal_cell_content/0.78954646
123MP0003567_abnormal_fetal_cardiomyocyte0.78540560
124MP0003937_abnormal_limbs/digits/tail_de0.77359581
125MP0000858_altered_metastatic_potential0.77236460
126MP0003436_decreased_susceptibility_to0.76798197
127MP0000716_abnormal_immune_system0.76574709
128MP0002161_abnormal_fertility/fecundity0.76476792
129MP0001853_heart_inflammation0.75935843
130MP0000350_abnormal_cell_proliferation0.75930858
131MP0009764_decreased_sensitivity_to0.75925100
132MP0002019_abnormal_tumor_incidence0.75581072
133MP0000647_abnormal_sebaceous_gland0.74825263
134MP0005499_abnormal_olfactory_system0.74747481
135MP0005394_taste/olfaction_phenotype0.74747481
136MP0002751_abnormal_autonomic_nervous0.73375304
137MP0000613_abnormal_salivary_gland0.73051374
138MP0002177_abnormal_outer_ear0.72042082
139MP0005389_reproductive_system_phenotype0.70949585
140MP0002735_abnormal_chemical_nociception0.70509904
141MP0002075_abnormal_coat/hair_pigmentati0.70392904
142MP0010030_abnormal_orbit_morphology0.70367263
143MP0001919_abnormal_reproductive_system0.69747372
144MP0001963_abnormal_hearing_physiology0.68628647
145MP0002160_abnormal_reproductive_system0.68005505
146MP0005195_abnormal_posterior_eye0.66753193
147MP0003936_abnormal_reproductive_system0.66641563
148MP0003699_abnormal_female_reproductive0.66489484
149MP0008004_abnormal_stomach_pH0.65754113
150MP0000689_abnormal_spleen_morphology0.64911735
151MP0002876_abnormal_thyroid_physiology0.64812472
152MP0000681_abnormal_thyroid_gland0.64186347
153MP0000470_abnormal_stomach_morphology0.63749567
154MP0002722_abnormal_immune_system0.63638724
155MP0000703_abnormal_thymus_morphology0.63587640
156MP0002429_abnormal_blood_cell0.63102001
157MP0006082_CNS_inflammation0.63093890
158MP0005391_vision/eye_phenotype0.61252264

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.60536457
2Chromsome breakage (HP:0040012)6.14083471
3Duplicated collecting system (HP:0000081)4.25325283
4Abnormality of the renal collecting system (HP:0004742)4.00006653
5Prostate neoplasm (HP:0100787)3.72121030
6Abnormality of the preputium (HP:0100587)3.53834038
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.41419792
8Meckel diverticulum (HP:0002245)3.40041906
9Acute necrotizing encephalopathy (HP:0006965)3.30463535
10Abnormality of the ileum (HP:0001549)3.24871661
11Abnormality of chromosome stability (HP:0003220)3.15433360
12Abnormality of DNA repair (HP:0003254)3.13139707
13Reticulocytopenia (HP:0001896)3.09446954
14Birth length less than 3rd percentile (HP:0003561)3.08653890
15Acute encephalopathy (HP:0006846)3.05268254
16Increased CSF lactate (HP:0002490)3.01444367
17Mitochondrial inheritance (HP:0001427)2.98487461
18Abnormal mitochondria in muscle tissue (HP:0008316)2.94008640
19Ectopic kidney (HP:0000086)2.93497161
20Clubbing of toes (HP:0100760)2.92558726
21Septo-optic dysplasia (HP:0100842)2.86466212
22Molar tooth sign on MRI (HP:0002419)2.86456334
23Abnormality of midbrain morphology (HP:0002418)2.86456334
24Recurrent abscess formation (HP:0002722)2.79790933
25Progressive macrocephaly (HP:0004481)2.74300982
26Upper limb muscle weakness (HP:0003484)2.64339266
27Abnormality of the labia minora (HP:0012880)2.57962717
28Hepatocellular necrosis (HP:0001404)2.55661763
29Colon cancer (HP:0003003)2.53577798
30Pendular nystagmus (HP:0012043)2.52740497
31Chronic obstructive pulmonary disease (HP:0006510)2.47634778
32Obstructive lung disease (HP:0006536)2.47634778
33Type II lissencephaly (HP:0007260)2.47038997
34Abnormality of the pons (HP:0007361)2.46057759
35Aplasia/Hypoplasia of the patella (HP:0006498)2.45390466
36Lipid accumulation in hepatocytes (HP:0006561)2.41412686
37Hypoplasia of the pons (HP:0012110)2.40873948
38Bone marrow hypocellularity (HP:0005528)2.37360260
39Increased hepatocellular lipid droplets (HP:0006565)2.34817208
40Hepatic necrosis (HP:0002605)2.32545119
41Nephronophthisis (HP:0000090)2.32312503
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.30825230
43Abnormality of alanine metabolism (HP:0010916)2.30825230
44Hyperalaninemia (HP:0003348)2.30825230
45Small intestinal stenosis (HP:0012848)2.29323244
46Duodenal stenosis (HP:0100867)2.29323244
47Triphalangeal thumb (HP:0001199)2.28438297
48Recurrent pneumonia (HP:0006532)2.28099455
49Abnormal number of erythroid precursors (HP:0012131)2.28008716
50Increased serum lactate (HP:0002151)2.27289484
51Duplication of thumb phalanx (HP:0009942)2.26283022
52Absent thumb (HP:0009777)2.23203246
53Aplasia cutis congenita (HP:0001057)2.21984163
54Sclerocornea (HP:0000647)2.20367693
55Cerebral edema (HP:0002181)2.17447756
56Retrobulbar optic neuritis (HP:0100654)2.14084500
57Optic neuritis (HP:0100653)2.14084500
58Abnormality of the prostate (HP:0008775)2.13879946
59Abnormal rod and cone electroretinograms (HP:0008323)2.12690899
60Absent septum pellucidum (HP:0001331)2.12261840
61Abnormality of the carotid arteries (HP:0005344)2.09805764
62Recurrent bacterial skin infections (HP:0005406)2.09467270
63Eczematoid dermatitis (HP:0000976)2.08942213
64Short thumb (HP:0009778)2.08431489
65Abnormality of the septum pellucidum (HP:0007375)2.07642720
66Nephroblastoma (Wilms tumor) (HP:0002667)2.06722527
67Microvesicular hepatic steatosis (HP:0001414)2.06521348
68Absent radius (HP:0003974)2.05872326
69Type I transferrin isoform profile (HP:0003642)2.05173846
70Osteomalacia (HP:0002749)2.03437983
71Abnormal ciliary motility (HP:0012262)2.02142698
72White forelock (HP:0002211)2.00777461
73Lactic acidosis (HP:0003128)2.00667154
74Optic disc pallor (HP:0000543)1.99806133
75Median cleft lip (HP:0000161)1.98913911
76Patchy hypopigmentation of hair (HP:0011365)1.98805363
77Retinal dysplasia (HP:0007973)1.95834918
78Embryonal renal neoplasm (HP:0011794)1.93887090
79Methylmalonic acidemia (HP:0002912)1.93364876
80Abnormal lung lobation (HP:0002101)1.92457114
81Aplasia/Hypoplasia of the sacrum (HP:0008517)1.91706585
82Aplasia/Hypoplasia involving the musculature (HP:0001460)1.91231877
83Abnormality of the renal medulla (HP:0100957)1.90918753
84Absent forearm bone (HP:0003953)1.90833853
85Aplasia involving forearm bones (HP:0009822)1.90833853
86Hypergonadotropic hypogonadism (HP:0000815)1.89843691
87Myelodysplasia (HP:0002863)1.89623407
88Pallor (HP:0000980)1.89551233
89Congenital sensorineural hearing impairment (HP:0008527)1.89130849
90Methylmalonic aciduria (HP:0012120)1.88923785
91Cerebellar dysplasia (HP:0007033)1.88701418
92Carpal bone hypoplasia (HP:0001498)1.87838573
93Horseshoe kidney (HP:0000085)1.87485194
94Small hand (HP:0200055)1.86865137
95Reduced antithrombin III activity (HP:0001976)1.86478482
96Renal cortical cysts (HP:0000803)1.86180381
97IgG deficiency (HP:0004315)1.84985690
98Absent/shortened dynein arms (HP:0200106)1.84462336
99Dynein arm defect of respiratory motile cilia (HP:0012255)1.84462336
100Optic nerve hypoplasia (HP:0000609)1.83814065
101Chronic hepatic failure (HP:0100626)1.83784796
102True hermaphroditism (HP:0010459)1.81845700
103Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.81659719
104Premature graying of hair (HP:0002216)1.81541425
105Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80741182
106Abnormal protein N-linked glycosylation (HP:0012347)1.80741182
107Abnormal protein glycosylation (HP:0012346)1.80741182
108Abnormal glycosylation (HP:0012345)1.80741182
109Abnormality of cells of the erythroid lineage (HP:0012130)1.80660605
110Recurrent lower respiratory tract infections (HP:0002783)1.80627149
111Abnormality of the renal cortex (HP:0011035)1.80584096
112Lissencephaly (HP:0001339)1.80503459
113Ependymoma (HP:0002888)1.79627559
114Abolished electroretinogram (ERG) (HP:0000550)1.79469627
115Abnormality of incisor morphology (HP:0011063)1.78799837
116Progressive microcephaly (HP:0000253)1.78291542
117Stomach cancer (HP:0012126)1.77706013
118Medial flaring of the eyebrow (HP:0010747)1.77650060
119Congenital stationary night blindness (HP:0007642)1.77552423
120Tubulointerstitial nephritis (HP:0001970)1.76604866
121Febrile seizures (HP:0002373)1.76535044
122Mediastinal lymphadenopathy (HP:0100721)1.76221632
123Abnormal respiratory motile cilium morphology (HP:0005938)1.76094487
124Abnormal respiratory epithelium morphology (HP:0012253)1.76094487
125Supernumerary spleens (HP:0009799)1.75823464
126Breast hypoplasia (HP:0003187)1.73791729
127Astigmatism (HP:0000483)1.73777428
128Conical tooth (HP:0000698)1.73162119
129Mesomelia (HP:0003027)1.72808522
130Abnormality of the duodenum (HP:0002246)1.72620496
131Volvulus (HP:0002580)1.72524412
132Rib fusion (HP:0000902)1.72198949
133Preaxial hand polydactyly (HP:0001177)1.71942927
134Glioma (HP:0009733)1.71880886
135Pancreatic cysts (HP:0001737)1.71863665
136Chronic mucocutaneous candidiasis (HP:0002728)1.71624380
137Recurrent cutaneous fungal infections (HP:0011370)1.71624380
138Sloping forehead (HP:0000340)1.71124250
139Tracheoesophageal fistula (HP:0002575)1.71033646
140Dandy-Walker malformation (HP:0001305)1.71007763
141Severe visual impairment (HP:0001141)1.69839420
142Lethargy (HP:0001254)1.69736137
143Aplasia/Hypoplasia of the fovea (HP:0008060)1.69098498
144Hypoplasia of the fovea (HP:0007750)1.69098498
145Abnormality of the axillary hair (HP:0100134)1.68995982
146Abnormality of secondary sexual hair (HP:0009888)1.68995982
147Attenuation of retinal blood vessels (HP:0007843)1.68183768
148Abnormality of the nasal septum (HP:0000419)1.67452300
149Patellar aplasia (HP:0006443)1.66126467
150Type 2 muscle fiber atrophy (HP:0003554)1.65833667
151Increased IgM level (HP:0003496)1.64530709
152Parakeratosis (HP:0001036)1.64287174
153Ureteral duplication (HP:0000073)1.62656294
154Oligohydramnios (HP:0001562)1.61565583
155Pancreatic fibrosis (HP:0100732)1.61426420
156Facial cleft (HP:0002006)1.60760767
157Pancytopenia (HP:0001876)1.60715167
1583-Methylglutaconic aciduria (HP:0003535)1.59900094
159Abnormal hair whorl (HP:0010721)1.59471141

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.91230730
2VRK23.29742691
3IRAK33.23813482
4ZAK3.22036032
5FRK3.00749056
6CASK2.92756109
7EIF2AK22.74187215
8BRSK22.73348308
9IRAK42.64293070
10MKNK22.38902654
11PBK2.36075194
12BLK2.26836000
13TXK2.24383720
14PLK42.11115452
15SRPK12.02093801
16MAP3K141.95517025
17BUB11.91022456
18TLK11.90822161
19VRK11.83116198
20MKNK11.82663409
21TAF11.81437148
22NEK11.79573121
23YES11.78616517
24TNIK1.68328592
25WNK31.67635313
26TRIM281.64815000
27NME11.51458686
28MAP4K21.47429378
29EIF2AK11.43116712
30BMPR1B1.41215551
31BRSK11.39386715
32CLK11.35629607
33WEE11.35241794
34NUAK11.33744046
35ADRBK21.31574599
36TEC1.29438679
37CDC71.28800723
38IRAK11.26282454
39NME21.25694553
40GRK11.24821542
41NEK61.23406324
42EIF2AK31.20723022
43CDK81.20503066
44GRK71.18329091
45IKBKB1.17973060
46ATR1.17362257
47TTK1.16915449
48PRPF4B1.15700276
49TAOK31.14873656
50PLK11.07393316
51STK40.96559225
52BMPR20.94167055
53CDK30.94105476
54SIK30.93995359
55NLK0.92773822
56STK38L0.92078564
57CDK70.90619742
58WNK40.89728792
59PDK20.88897825
60JAK30.88731270
61MUSK0.87664856
62BRD40.86055491
63CHEK20.85704222
64BCKDK0.85505070
65CSNK1G30.83597882
66TGFBR10.81389651
67INSRR0.80433528
68IRAK20.79913501
69CSNK1G10.79820258
70PIM20.77871085
71PNCK0.77273362
72PRKCI0.74574857
73PLK30.74519139
74NEK90.73385047
75AURKB0.73347971
76AKT30.72358994
77IKBKE0.72045607
78LYN0.71218263
79MARK30.71152934
80KIT0.71048020
81PASK0.71037839
82PKN10.70982957
83MAP2K70.69873496
84TNK20.69189458
85DYRK30.68847144
86OXSR10.68773539
87DYRK20.68512864
88CSNK1G20.66631709
89PIM10.66274762
90STK390.65870765
91TRPM70.65422193
92CSNK1A1L0.64949862
93RPS6KA50.63205160
94CCNB10.62006992
95STK30.59533578
96BCR0.59492626
97MELK0.58639837
98MAP3K40.58003134
99ACVR1B0.56342490
100MAPK130.55204465
101BTK0.53759478
102ATM0.53423220
103STK240.51925631
104RPS6KA40.51557347
105AURKA0.49555859
106MST40.48612139
107EPHA20.47975598
108CSNK2A10.47658383
109CHUK0.45210497
110EPHA30.44735555
111LCK0.44142517
112OBSCN0.44057591
113PIK3CG0.42364339
114CDK10.42223460
115SYK0.40330121
116PRKCG0.37631257
117CDK40.36479434
118MAP4K10.35226650
119NEK20.34951492
120CHEK10.34932382
121PRKCD0.34422699
122PIK3CA0.33978240
123SGK20.33886982
124PLK20.33884962
125PINK10.33538901
126ADRBK10.33439272
127TSSK60.32638969
128STK100.32062801
129PRKCE0.31781592
130RIPK40.31591934
131CDK20.31353433
132CAMKK20.30845966
133BRAF0.30634144
134CSNK1A10.30424387
135TAOK20.30265996
136TIE10.29804648
137CSNK2A20.29110865
138CDK90.28837426
139MAP3K80.27660274
140DAPK10.25220814
141CSNK1D0.24136880

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.27879477
2Fanconi anemia pathway_Homo sapiens_hsa034603.24039843
3DNA replication_Homo sapiens_hsa030303.12790173
4Mismatch repair_Homo sapiens_hsa034303.05018106
5RNA polymerase_Homo sapiens_hsa030202.54092037
6Non-homologous end-joining_Homo sapiens_hsa034502.47305651
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.46132623
8Base excision repair_Homo sapiens_hsa034102.31459614
9Nucleotide excision repair_Homo sapiens_hsa034202.24490684
10Ribosome_Homo sapiens_hsa030102.15013454
11Proteasome_Homo sapiens_hsa030502.01665900
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00823955
13Pyrimidine metabolism_Homo sapiens_hsa002401.94627719
14Basal transcription factors_Homo sapiens_hsa030221.88277136
15Graft-versus-host disease_Homo sapiens_hsa053321.87279901
16One carbon pool by folate_Homo sapiens_hsa006701.83523881
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79664214
18Selenocompound metabolism_Homo sapiens_hsa004501.77606393
19Spliceosome_Homo sapiens_hsa030401.63222348
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.62856241
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.57314507
22Cell cycle_Homo sapiens_hsa041101.54923577
23Allograft rejection_Homo sapiens_hsa053301.51135363
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42774238
25Autoimmune thyroid disease_Homo sapiens_hsa053201.41506050
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.35431759
27Hematopoietic cell lineage_Homo sapiens_hsa046401.33306929
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31929243
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28635252
30Purine metabolism_Homo sapiens_hsa002301.25279319
31p53 signaling pathway_Homo sapiens_hsa041151.25245817
32RNA degradation_Homo sapiens_hsa030181.23553385
33Measles_Homo sapiens_hsa051621.21751492
34Herpes simplex infection_Homo sapiens_hsa051681.18607674
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17312933
36Sulfur relay system_Homo sapiens_hsa041221.16433802
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16213034
38Primary immunodeficiency_Homo sapiens_hsa053401.15916102
39RNA transport_Homo sapiens_hsa030131.15374251
40Other glycan degradation_Homo sapiens_hsa005111.15034151
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.13836749
42Sphingolipid metabolism_Homo sapiens_hsa006001.13321263
43Arachidonic acid metabolism_Homo sapiens_hsa005901.12850376
44Propanoate metabolism_Homo sapiens_hsa006401.11220069
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10670124
46Asthma_Homo sapiens_hsa053101.10352171
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07738243
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06494309
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05864919
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05800828
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04201856
52Butanoate metabolism_Homo sapiens_hsa006501.02573926
53Phototransduction_Homo sapiens_hsa047441.01227586
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99718470
55Rheumatoid arthritis_Homo sapiens_hsa053230.99483392
56Caffeine metabolism_Homo sapiens_hsa002320.99241323
57Folate biosynthesis_Homo sapiens_hsa007900.97832451
58Nitrogen metabolism_Homo sapiens_hsa009100.94839844
59Fatty acid elongation_Homo sapiens_hsa000620.94684450
60Leishmaniasis_Homo sapiens_hsa051400.93893708
61Epstein-Barr virus infection_Homo sapiens_hsa051690.92666287
62Systemic lupus erythematosus_Homo sapiens_hsa053220.88992204
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88140744
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87667413
65Glutathione metabolism_Homo sapiens_hsa004800.87432902
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86134663
67Oxidative phosphorylation_Homo sapiens_hsa001900.86100324
68Malaria_Homo sapiens_hsa051440.84982982
69Tryptophan metabolism_Homo sapiens_hsa003800.83795063
70Protein export_Homo sapiens_hsa030600.81640775
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79609623
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77674369
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75063079
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73111408
75Huntingtons disease_Homo sapiens_hsa050160.73073018
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72513892
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71250812
78Oocyte meiosis_Homo sapiens_hsa041140.70340754
79Influenza A_Homo sapiens_hsa051640.69746536
80mRNA surveillance pathway_Homo sapiens_hsa030150.69330098
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68047435
82Metabolic pathways_Homo sapiens_hsa011000.67277932
83Phagosome_Homo sapiens_hsa041450.65981778
84Ether lipid metabolism_Homo sapiens_hsa005650.65388257
85Pyruvate metabolism_Homo sapiens_hsa006200.65091484
86Legionellosis_Homo sapiens_hsa051340.60463122
87Apoptosis_Homo sapiens_hsa042100.60144503
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.59349138
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58725847
90TNF signaling pathway_Homo sapiens_hsa046680.57753634
91Parkinsons disease_Homo sapiens_hsa050120.56852279
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.56783339
93Type I diabetes mellitus_Homo sapiens_hsa049400.56482722
94Osteoclast differentiation_Homo sapiens_hsa043800.53847765
95Peroxisome_Homo sapiens_hsa041460.53318393
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50196205
97Antigen processing and presentation_Homo sapiens_hsa046120.49620168
98Vitamin digestion and absorption_Homo sapiens_hsa049770.49022465
99Vitamin B6 metabolism_Homo sapiens_hsa007500.49003687
100Cardiac muscle contraction_Homo sapiens_hsa042600.47968047
101HTLV-I infection_Homo sapiens_hsa051660.47688727
102Regulation of autophagy_Homo sapiens_hsa041400.46613332
103Tuberculosis_Homo sapiens_hsa051520.46022692
104Sulfur metabolism_Homo sapiens_hsa009200.45757774
105Pertussis_Homo sapiens_hsa051330.45630094
106Viral carcinogenesis_Homo sapiens_hsa052030.44886887
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43696764
108Nicotine addiction_Homo sapiens_hsa050330.43643153
109Olfactory transduction_Homo sapiens_hsa047400.43386070
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43184935
111Hepatitis B_Homo sapiens_hsa051610.42992490
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41642955
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40113707
114African trypanosomiasis_Homo sapiens_hsa051430.39601334
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39283705
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.38771879
117Linoleic acid metabolism_Homo sapiens_hsa005910.38352527
118Taste transduction_Homo sapiens_hsa047420.37347836
119Chemokine signaling pathway_Homo sapiens_hsa040620.36077341
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.36013089
121Melanoma_Homo sapiens_hsa052180.34765953
122Chemical carcinogenesis_Homo sapiens_hsa052040.32351306
123Primary bile acid biosynthesis_Homo sapiens_hsa001200.32125943
124Salmonella infection_Homo sapiens_hsa051320.30322057
125Steroid biosynthesis_Homo sapiens_hsa001000.30209323
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29483287
127Basal cell carcinoma_Homo sapiens_hsa052170.29332605
128Serotonergic synapse_Homo sapiens_hsa047260.29330316
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29260639
130Small cell lung cancer_Homo sapiens_hsa052220.28879571
131MicroRNAs in cancer_Homo sapiens_hsa052060.28279172
132Alzheimers disease_Homo sapiens_hsa050100.27705290
133Hepatitis C_Homo sapiens_hsa051600.24609780
134Collecting duct acid secretion_Homo sapiens_hsa049660.24607472
135N-Glycan biosynthesis_Homo sapiens_hsa005100.23574308
136Drug metabolism - other enzymes_Homo sapiens_hsa009830.23245459
137Lysine degradation_Homo sapiens_hsa003100.22454002
138Fatty acid metabolism_Homo sapiens_hsa012120.20574028
139beta-Alanine metabolism_Homo sapiens_hsa004100.20160610
140Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.16155648
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.15840823
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.11378197
143Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.11091629

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