HAVCR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4, 12 and 19. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)8.89933934
2doxorubicin metabolic process (GO:0044598)8.89933934
3daunorubicin metabolic process (GO:0044597)8.89933934
4fat-soluble vitamin catabolic process (GO:0042363)8.73532813
5vitamin catabolic process (GO:0009111)8.73532813
6vitamin D metabolic process (GO:0042359)8.41354448
7aminoglycoside antibiotic metabolic process (GO:0030647)7.88337190
8interferon-gamma secretion (GO:0072643)6.97089715
9cellular response to vitamin D (GO:0071305)6.34478309
10regulation of cardioblast differentiation (GO:0051890)6.00313086
11urate metabolic process (GO:0046415)5.75062982
12regulation of guanylate cyclase activity (GO:0031282)5.74941394
13sulfate transmembrane transport (GO:1902358)5.53256607
14very-low-density lipoprotein particle assembly (GO:0034379)5.24928920
15toxin transport (GO:1901998)5.20759549
16folic acid transport (GO:0015884)5.12070970
17iron ion import (GO:0097286)4.98290619
18folic acid metabolic process (GO:0046655)4.94916321
19modified amino acid transport (GO:0072337)4.89345884
20cellular response to vitamin (GO:0071295)4.82597130
21drug transmembrane transport (GO:0006855)4.82020693
22sulfate transport (GO:0008272)4.77670344
23cysteine metabolic process (GO:0006534)4.70326489
24regulation of transforming growth factor beta2 production (GO:0032909)4.60257603
25phosphate ion transmembrane transport (GO:0035435)4.43728658
26drug transport (GO:0015893)4.41871863
27positive regulation of guanylate cyclase activity (GO:0031284)4.41547448
28water-soluble vitamin biosynthetic process (GO:0042364)4.34558540
29excretion (GO:0007588)4.32958958
30cytidine deamination (GO:0009972)4.29678737
31cytidine metabolic process (GO:0046087)4.29678737
32cytidine catabolic process (GO:0006216)4.29678737
33regulation of retinoic acid receptor signaling pathway (GO:0048385)4.27265793
34regulation of integrin-mediated signaling pathway (GO:2001044)4.21732679
35intestinal cholesterol absorption (GO:0030299)4.18892289
36glycoside metabolic process (GO:0016137)4.15895259
37negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.12370178
38plasma lipoprotein particle assembly (GO:0034377)4.10822686
39positive regulation of hair cycle (GO:0042635)4.06159904
40positive regulation of hair follicle development (GO:0051798)4.06159904
41phosphate ion transport (GO:0006817)3.95254105
42negative regulation of metanephros development (GO:0072217)3.92507263
43response to dietary excess (GO:0002021)3.90102236
44quinone metabolic process (GO:1901661)3.88984031
45vitamin transport (GO:0051180)3.88210715
46amino sugar catabolic process (GO:0046348)3.79260616
47sulfur compound transport (GO:0072348)3.76324352
48response to vitamin D (GO:0033280)3.76064215
49pyrimidine-containing compound transmembrane transport (GO:0072531)3.70724831
50positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.65834605
51purine nucleobase biosynthetic process (GO:0009113)3.64496095
52regulation of histone H3-K27 methylation (GO:0061085)3.64420435
53fat-soluble vitamin metabolic process (GO:0006775)3.58299521
54regulation of transforming growth factor beta1 production (GO:0032908)3.58075236
55peptidyl-glutamic acid carboxylation (GO:0017187)3.53794093
56protein carboxylation (GO:0018214)3.53794093
57cellular glucuronidation (GO:0052695)3.51935409
58basic amino acid transport (GO:0015802)3.49084811
59quaternary ammonium group transport (GO:0015697)3.48343295
60uronic acid metabolic process (GO:0006063)3.46294665
61glucuronate metabolic process (GO:0019585)3.46294665
62protein-lipid complex assembly (GO:0065005)3.46235073
63negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.45356285
64glutathione biosynthetic process (GO:0006750)3.44431658
65protein hydroxylation (GO:0018126)3.43746462
66import into cell (GO:0098657)3.42740203
67lung-associated mesenchyme development (GO:0060484)3.39955558
68vitamin transmembrane transport (GO:0035461)3.39786178
69nucleotide transmembrane transport (GO:1901679)3.31934330
70spindle assembly involved in mitosis (GO:0090307)3.31190795
71calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.29410629
72phospholipid homeostasis (GO:0055091)3.29059938
73fructose metabolic process (GO:0006000)3.29050671
74nonribosomal peptide biosynthetic process (GO:0019184)3.28299959
75regulation of prostaglandin secretion (GO:0032306)3.26863967
76pentose-phosphate shunt (GO:0006098)3.26682642
77regulation of cholesterol esterification (GO:0010872)3.24934136
78cholesterol efflux (GO:0033344)3.24724829
79AMP metabolic process (GO:0046033)3.24234320
80response to hydroperoxide (GO:0033194)3.22508832
81positive regulation of prostaglandin secretion (GO:0032308)3.22066529
82negative regulation of epidermal cell differentiation (GO:0045605)3.21524092
83positive regulation of SMAD protein import into nucleus (GO:0060391)3.21033218
84progesterone metabolic process (GO:0042448)3.20989221
85amino acid salvage (GO:0043102)3.19657718
86L-methionine salvage (GO:0071267)3.19657718
87L-methionine biosynthetic process (GO:0071265)3.19657718
88peptidyl-proline hydroxylation (GO:0019511)3.18607635
89NADH metabolic process (GO:0006734)3.16198969
90NADPH regeneration (GO:0006740)3.14515557
91heme transport (GO:0015886)3.14088854
92regulation of cGMP biosynthetic process (GO:0030826)3.09999411
93nephron tubule formation (GO:0072079)3.09956962
94dopamine biosynthetic process (GO:0042416)3.09945907
95viral entry into host cell (GO:0046718)3.09909090
96notochord development (GO:0030903)3.09717595
97high-density lipoprotein particle remodeling (GO:0034375)3.09380720
98intestinal epithelial cell development (GO:0060576)3.09240760
99serine family amino acid metabolic process (GO:0009069)3.08728651
100primary alcohol catabolic process (GO:0034310)3.07871626
101prostaglandin metabolic process (GO:0006693)3.05753614
102prostanoid metabolic process (GO:0006692)3.05753614
103glycosylceramide metabolic process (GO:0006677)3.05219002
1044-hydroxyproline metabolic process (GO:0019471)3.05106133
105regulation of SMAD protein import into nucleus (GO:0060390)3.04762968
106diol metabolic process (GO:0034311)3.03949614
107thrombin receptor signaling pathway (GO:0070493)3.01940887
108regulation of mesenchymal cell apoptotic process (GO:2001053)3.01795504
109creatine metabolic process (GO:0006600)3.01139250
110ribosome assembly (GO:0042255)3.01067177
111nucleobase biosynthetic process (GO:0046112)3.00260640
112labyrinthine layer development (GO:0060711)3.00151158
113histone-serine phosphorylation (GO:0035404)3.00038939
114carnitine transport (GO:0015879)2.99930329
115amino-acid betaine transport (GO:0015838)2.99930329
116regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.99838793
117sphingosine metabolic process (GO:0006670)2.98635821
118regulation of early endosome to late endosome transport (GO:2000641)2.97128487
119DNA deamination (GO:0045006)2.96806815
120oligosaccharide catabolic process (GO:0009313)2.96737417
121sphingomyelin metabolic process (GO:0006684)2.95227055
122N-acetylneuraminate metabolic process (GO:0006054)2.92927783
123positive regulation of respiratory burst (GO:0060267)2.92857645
124pseudouridine synthesis (GO:0001522)2.92700206
125fibroblast migration (GO:0010761)2.92104134
126homocysteine metabolic process (GO:0050667)2.92100405
127steroid catabolic process (GO:0006706)2.91613840
128nephron epithelium morphogenesis (GO:0072088)2.90004715
129nephron tubule morphogenesis (GO:0072078)2.90004715
130acylglycerol homeostasis (GO:0055090)2.89155978
131triglyceride homeostasis (GO:0070328)2.89155978
132pyrimidine ribonucleoside catabolic process (GO:0046133)2.88066519
133negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.87810846
134glycosphingolipid biosynthetic process (GO:0006688)2.87097167
135organic cation transport (GO:0015695)2.86976945
136positive regulation of T cell apoptotic process (GO:0070234)2.86923873
137pantothenate metabolic process (GO:0015939)2.86852199
138positive regulation of epidermis development (GO:0045684)2.85373163
139pathway-restricted SMAD protein phosphorylation (GO:0060389)2.83864882
140CDP-diacylglycerol metabolic process (GO:0046341)2.83143366
141galactose catabolic process (GO:0019388)2.80257379
142cell adhesion mediated by integrin (GO:0033627)2.80229130
143cofactor transport (GO:0051181)2.78412001
144regulation of oxidative phosphorylation (GO:0002082)2.78330403
145serine family amino acid catabolic process (GO:0009071)2.77354893
146regulation of cellular respiration (GO:0043457)2.75048332
147regulation of hippo signaling (GO:0035330)2.74909330
148glyoxylate metabolic process (GO:0046487)2.74247192
149regulation of apoptotic cell clearance (GO:2000425)2.74036827
150positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.73573093
151gland morphogenesis (GO:0022612)2.73249662
152lysine metabolic process (GO:0006553)2.72250188
153lysine catabolic process (GO:0006554)2.72250188
154regulation of cytokine secretion involved in immune response (GO:0002739)2.71310583
155ADP metabolic process (GO:0046031)2.71173784
156low-density lipoprotein particle remodeling (GO:0034374)2.69685823
157carnitine transmembrane transport (GO:1902603)2.69221485
158DNA damage induced protein phosphorylation (GO:0006975)2.69159844
159regulation of cellular amino acid metabolic process (GO:0006521)2.67147791
160plasma lipoprotein particle clearance (GO:0034381)2.66205291
161reverse cholesterol transport (GO:0043691)2.65441646
162carbohydrate derivative transport (GO:1901264)2.64055560
163somite rostral/caudal axis specification (GO:0032525)2.63743513
164artery smooth muscle contraction (GO:0014824)2.62265184
165regulation of metalloenzyme activity (GO:0048552)2.60507944
166regulation of apoptotic process involved in morphogenesis (GO:1902337)2.60417329
167regulation of bile acid biosynthetic process (GO:0070857)2.60199938
168respiratory chain complex IV assembly (GO:0008535)2.59639709
169regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.59034681
170plasma lipoprotein particle organization (GO:0071827)2.58401286
171regulation of acrosome reaction (GO:0060046)2.56007355
172L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.55729379
173L-phenylalanine metabolic process (GO:0006558)2.54154004
174erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.54154004
175male meiosis I (GO:0007141)2.53637556
176rRNA modification (GO:0000154)2.52843841
177C4-dicarboxylate transport (GO:0015740)2.51184493
178retinal metabolic process (GO:0042574)2.49637448
179C21-steroid hormone metabolic process (GO:0008207)2.49410227
180nitric oxide biosynthetic process (GO:0006809)2.48304229
181primitive streak formation (GO:0090009)2.44023400
182transcription from mitochondrial promoter (GO:0006390)2.40925468
183regulation of chemokine secretion (GO:0090196)2.40738611

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.26385114
2ZNF274_21170338_ChIP-Seq_K562_Hela4.07492520
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.72928588
4AR_21909140_ChIP-Seq_LNCAP_Human3.57358907
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.28883219
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.24645563
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.24098366
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.91451974
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.68985834
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.61693404
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.56610636
12STAT3_1855785_ChIP-Seq_MESCs_Mouse2.53148846
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.50607062
14SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.48105505
15HIF1A_21447827_ChIP-Seq_MCF-7_Human2.31762393
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.30539384
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.24122808
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20316793
19IRF1_19129219_ChIP-ChIP_H3396_Human2.17330358
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11244142
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.10856309
22SALL4_18804426_ChIP-ChIP_XEN_Mouse2.07411534
23CLOCK_20551151_ChIP-Seq_293T_Human2.06265053
24RXR_22158963_ChIP-Seq_LIVER_Mouse2.05809553
25TCF3_18692474_ChIP-Seq_MEFs_Mouse2.02549482
26PPARA_22158963_ChIP-Seq_LIVER_Mouse2.01205214
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.00438464
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.98998695
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.97600999
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91917372
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.91878105
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.86638391
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85596007
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.80493510
35NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.79128454
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.78970484
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78779694
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.78464896
39VDR_22108803_ChIP-Seq_LS180_Human1.77252216
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.76481327
41CBP_20019798_ChIP-Seq_JUKART_Human1.76481327
42TP53_22573176_ChIP-Seq_HFKS_Human1.74787446
43EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.73394267
44NANOG_18692474_ChIP-Seq_MEFs_Mouse1.72827768
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.70254507
46GBX2_23144817_ChIP-Seq_PC3_Human1.67882890
47OCT4_18692474_ChIP-Seq_MEFs_Mouse1.67859935
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67649984
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.67353910
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67202747
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67009925
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.66520709
53ZNF263_19887448_ChIP-Seq_K562_Human1.66360726
54PPAR_26484153_Chip-Seq_NCI-H1993_Human1.65988268
55GATA1_26923725_Chip-Seq_HPCs_Mouse1.65014879
56* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.62072607
57CDX2_20551321_ChIP-Seq_CACO-2_Human1.60317679
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60224381
59TRIM28_21343339_ChIP-Seq_HEK293_Human1.59999008
60SOX2_18692474_ChIP-Seq_MEFs_Mouse1.56303207
61TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.56251073
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55056666
63ESR1_15608294_ChIP-ChIP_MCF-7_Human1.53959036
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.52257750
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51499820
66HNF4A_19822575_ChIP-Seq_HepG2_Human1.48742544
67NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.48428621
68MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48155365
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47494460
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47319143
71PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.47044891
72E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46730253
73ATF3_27146783_Chip-Seq_COLON_Human1.46043687
74SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.44873274
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44682347
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44602494
77JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44105549
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.43790954
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.42176720
80MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41327472
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.39663787
82GATA4_25053715_ChIP-Seq_YYC3_Human1.37827696
83AHR_22903824_ChIP-Seq_MCF-7_Human1.33476821
84ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33098165
85ELF1_17652178_ChIP-ChIP_JURKAT_Human1.32950679
86NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32488504
87RACK7_27058665_Chip-Seq_MCF-7_Human1.30491155
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30401220
89GABP_17652178_ChIP-ChIP_JURKAT_Human1.30311175
90LXR_22158963_ChIP-Seq_LIVER_Mouse1.30007377
91ELK1_19687146_ChIP-ChIP_HELA_Human1.29096955
92NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28453218
93* FOXA2_19822575_ChIP-Seq_HepG2_Human1.28345172
94TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.27278723
95TP53_18474530_ChIP-ChIP_U2OS_Human1.26896522
96CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26792330
97TAF15_26573619_Chip-Seq_HEK293_Human1.26502555
98TP53_16413492_ChIP-PET_HCT116_Human1.25331300
99KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24668996
100HOXB7_26014856_ChIP-Seq_BT474_Human1.24197139
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23920242
102SRF_21415370_ChIP-Seq_HL-1_Mouse1.23876730
103* CJUN_26792858_Chip-Seq_BT549_Human1.23257840
104SALL1_21062744_ChIP-ChIP_HESCs_Human1.21479490
105NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.19639419
106FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.19193860
107ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19012994
108SOX17_20123909_ChIP-Seq_XEN_Mouse1.18910342
109ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18834724
110ELK1_22589737_ChIP-Seq_MCF10A_Human1.18363218
111P300_19829295_ChIP-Seq_ESCs_Human1.18340204
112ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17775790
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17744733
114EST1_17652178_ChIP-ChIP_JURKAT_Human1.16128007
115TP63_17297297_ChIP-ChIP_HaCaT_Human1.15530549
116SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.14607458
117SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.14607458
118TFEB_21752829_ChIP-Seq_HELA_Human1.14324968
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13435809
120FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12743820
121GATA6_25053715_ChIP-Seq_YYC3_Human1.12271382
122GABP_19822575_ChIP-Seq_HepG2_Human1.12209903
123EGR1_19032775_ChIP-ChIP_M12_Human1.11495179
124SMAD3_21741376_ChIP-Seq_HESCs_Human1.08764386
125NANOG_19829295_ChIP-Seq_ESCs_Human1.06737326
126SOX2_19829295_ChIP-Seq_ESCs_Human1.06737326
127ARNT_22903824_ChIP-Seq_MCF-7_Human1.06481870
128ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06269774
129TCF4_22108803_ChIP-Seq_LS180_Human1.05347614
130E2F7_22180533_ChIP-Seq_HELA_Human1.05188186
131GATA3_24758297_ChIP-Seq_MCF-7_Human1.03442557
132CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03323262
133MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03226449
134NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02558154
135POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02131364
136TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01980217
137FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01481109
138NFE2_27457419_Chip-Seq_LIVER_Mouse1.01112965
139XRN2_22483619_ChIP-Seq_HELA_Human1.00668725
140AR_20517297_ChIP-Seq_VCAP_Human1.00582420
141CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00118084
142CDX2_22108803_ChIP-Seq_LS180_Human0.99826704
143MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99796372
144* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.99791561
145NCOR_22424771_ChIP-Seq_293T_Human0.99484808
146SOX2_20726797_ChIP-Seq_SW620_Human0.99435200
147EGR1_19374776_ChIP-ChIP_THP-1_Human0.99296268
148EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99206002
149IRF8_21731497_ChIP-ChIP_J774_Mouse0.99162906
150NANOG_16518401_ChIP-PET_MESCs_Mouse0.99123853
151EOMES_21245162_ChIP-Seq_HESCs_Human0.99000571
152FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98752976
153SMAD4_21799915_ChIP-Seq_A2780_Human0.96555685
154SMAD4_21741376_ChIP-Seq_HESCs_Human0.95969081
155TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95291665
156POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94116506
157ELK3_25401928_ChIP-Seq_HUVEC_Human0.93600385
158GATA3_21878914_ChIP-Seq_MCF-7_Human0.92624058
159ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92546600
160SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92526098
161* FOXA1_25329375_ChIP-Seq_VCAP_Human0.92381532
162* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92381532
163SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92087165
164GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.90939239
165ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89549334
166CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88890762
167ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88109936
168CHD1_26751641_Chip-Seq_LNCaP_Human0.87633077

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system6.48856108
2MP0004019_abnormal_vitamin_homeostasis5.06402218
3MP0003950_abnormal_plasma_membrane3.61561573
4MP0002139_abnormal_hepatobiliary_system3.36917833
5MP0001756_abnormal_urination3.16257882
6MP0001765_abnormal_ion_homeostasis3.12789117
7MP0009643_abnormal_urine_homeostasis3.07405055
8MP0003195_calcinosis2.92212598
9MP0003300_gastrointestinal_ulcer2.87081326
10MP0005365_abnormal_bile_salt2.81603321
11MP0010234_abnormal_vibrissa_follicle2.77397432
12MP0005636_abnormal_mineral_homeostasis2.74971584
13MP0005332_abnormal_amino_acid2.72095798
14MP0001958_emphysema2.70061835
15MP0008875_abnormal_xenobiotic_pharmacok2.68613353
16MP0003252_abnormal_bile_duct2.61664816
17MP0006054_spinal_hemorrhage2.61609535
18MP0002136_abnormal_kidney_physiology2.59312338
19MP0005360_urolithiasis2.48936449
20MP0009840_abnormal_foam_cell2.46650063
21MP0003693_abnormal_embryo_hatching2.34889211
22MP0000647_abnormal_sebaceous_gland2.34629798
23MP0003890_abnormal_embryonic-extraembry2.32433166
24MP0005058_abnormal_lysosome_morphology2.26417682
25MP0008872_abnormal_physiological_respon2.12767105
26MP0010329_abnormal_lipoprotein_level2.01500596
27MP0002876_abnormal_thyroid_physiology1.88768350
28MP0001661_extended_life_span1.76795790
29MP0005377_hearing/vestibular/ear_phenot1.74681436
30MP0003878_abnormal_ear_physiology1.74681436
31MP0002736_abnormal_nociception_after1.74135964
32MP0003191_abnormal_cellular_cholesterol1.70781596
33MP0003329_amyloid_beta_deposits1.68830065
34MP0002928_abnormal_bile_duct1.67872178
35MP0005408_hypopigmentation1.67348660
36MP0004957_abnormal_blastocyst_morpholog1.65052191
37MP0001968_abnormal_touch/_nociception1.55699308
38MP0010352_gastrointestinal_tract_polyps1.53817761
39MP0000604_amyloidosis1.53808154
40MP0004264_abnormal_extraembryonic_tissu1.52193872
41MP0001986_abnormal_taste_sensitivity1.44613422
42MP0003111_abnormal_nucleus_morphology1.43466998
43MP0001727_abnormal_embryo_implantation1.43177663
44MP0003718_maternal_effect1.41607731
45MP0005395_other_phenotype1.41438811
46MP0002168_other_aberrant_phenotype1.41123253
47MP0003566_abnormal_cell_adhesion1.40534494
48MP0002796_impaired_skin_barrier1.36442351
49MP0003045_fibrosis1.36237843
50MP0000681_abnormal_thyroid_gland1.31321358
51MP0002254_reproductive_system_inflammat1.30990339
52MP0004133_heterotaxia1.26591791
53MP0004043_abnormal_pH_regulation1.25361398
54MP0004782_abnormal_surfactant_physiolog1.24562586
55MP0005084_abnormal_gallbladder_morpholo1.22768444
56MP0010678_abnormal_skin_adnexa1.22404837
57MP0003315_abnormal_perineum_morphology1.22141604
58MP0000427_abnormal_hair_cycle1.20580048
59MP0003567_abnormal_fetal_cardiomyocyte1.19371847
60MP0000013_abnormal_adipose_tissue1.15047916
61MP0006276_abnormal_autonomic_nervous1.14362486
62MP0005551_abnormal_eye_electrophysiolog1.11658172
63MP0005410_abnormal_fertilization1.10061386
64MP0006035_abnormal_mitochondrial_morpho1.08026717
65MP0003186_abnormal_redox_activity1.05852336
66MP0003806_abnormal_nucleotide_metabolis1.05628427
67MP0008438_abnormal_cutaneous_collagen1.05185073
68MP0002135_abnormal_kidney_morphology1.04944450
69MP0004084_abnormal_cardiac_muscle1.02256707
70MP0001348_abnormal_lacrimal_gland1.02011565
71MP0006082_CNS_inflammation1.01028643
72MP0001764_abnormal_homeostasis1.00466219
73MP0004883_abnormal_blood_vessel0.98492766
74MP0003183_abnormal_peptide_metabolism0.96077565
75MP0005584_abnormal_enzyme/coenzyme_acti0.95239867
76MP0000358_abnormal_cell_content/0.92665719
77MP0005085_abnormal_gallbladder_physiolo0.92393247
78MP0004272_abnormal_basement_membrane0.91617460
79MP0001730_embryonic_growth_arrest0.90476180
80MP0008260_abnormal_autophagy0.90135508
81MP0005646_abnormal_pituitary_gland0.87698917
82MP0003646_muscle_fatigue0.86288443
83MP0000639_abnormal_adrenal_gland0.85970869
84MP0001666_abnormal_nutrient_absorption0.85651793
85MP0005023_abnormal_wound_healing0.85216325
86MP0005670_abnormal_white_adipose0.85118945
87MP0005379_endocrine/exocrine_gland_phen0.84632859
88MP0008961_abnormal_basal_metabolism0.83934665
89MP0008775_abnormal_heart_ventricle0.82443356
90MP0000383_abnormal_hair_follicle0.81333048
91MP0003091_abnormal_cell_migration0.81251612
92MP0008932_abnormal_embryonic_tissue0.78241957
93MP0005220_abnormal_exocrine_pancreas0.77596221
94MP0005409_darkened_coat_color0.77229064
95MP0005195_abnormal_posterior_eye0.76522406
96MP0003943_abnormal_hepatobiliary_system0.76326472
97MP0005165_increased_susceptibility_to0.76059657
98MP0006292_abnormal_olfactory_placode0.74216896
99MP0002233_abnormal_nose_morphology0.73967497
100MP0005389_reproductive_system_phenotype0.73946678
101MP0001881_abnormal_mammary_gland0.73302750
102MP0001286_abnormal_eye_development0.73263727
103MP0008789_abnormal_olfactory_epithelium0.72848204
104MP0002102_abnormal_ear_morphology0.72560090
105MP0000627_abnormal_mammary_gland0.72165491
106MP0003879_abnormal_hair_cell0.71698410
107MP0000598_abnormal_liver_morphology0.69691998
108MP0001177_atelectasis0.69570089
109MP0009278_abnormal_bone_marrow0.68801619
110MP0004484_altered_response_of0.67907396
111MP0005501_abnormal_skin_physiology0.67279779
112MP0000609_abnormal_liver_physiology0.67169303
113MP0008004_abnormal_stomach_pH0.66775917
114MP0002909_abnormal_adrenal_gland0.66375953
115MP0001485_abnormal_pinna_reflex0.64862721
116MP0000377_abnormal_hair_follicle0.63055698
117MP0001915_intracranial_hemorrhage0.62873375
118MP0003077_abnormal_cell_cycle0.62870984
119MP0001919_abnormal_reproductive_system0.62318288
120MP0002086_abnormal_extraembryonic_tissu0.62242710
121MP0003638_abnormal_response/metabolism_0.62179000
122MP0002089_abnormal_postnatal_growth/wei0.61741508
123MP0003936_abnormal_reproductive_system0.60551288
124MP0000230_abnormal_systemic_arterial0.60014053
125MP0005164_abnormal_response_to0.59995731
126MP0001929_abnormal_gametogenesis0.59883432
127MP0006036_abnormal_mitochondrial_physio0.58907661
128MP0001664_abnormal_digestion0.58494099
129MP0002098_abnormal_vibrissa_morphology0.58493121
130MP0001542_abnormal_bone_strength0.58072074
131MP0002269_muscular_atrophy0.57705585
132MP0000343_altered_response_to0.57259129
133MP0002163_abnormal_gland_morphology0.56897331
134MP0003938_abnormal_ear_development0.56665089
135MP0002210_abnormal_sex_determination0.56004786
136MP0005166_decreased_susceptibility_to0.54623057
137MP0001216_abnormal_epidermal_layer0.54609125
138MP0004215_abnormal_myocardial_fiber0.53984389
139MP0001293_anophthalmia0.53959293
140MP0009333_abnormal_splenocyte_physiolog0.53923190
141MP0001944_abnormal_pancreas_morphology0.53862881
142MP0001672_abnormal_embryogenesis/_devel0.53589359
143MP0005380_embryogenesis_phenotype0.53589359
144MP0003632_abnormal_nervous_system0.53390221
145MP0002088_abnormal_embryonic_growth/wei0.53354010
146MP0002118_abnormal_lipid_homeostasis0.53348057
147MP0001697_abnormal_embryo_size0.53045285
148MP0005319_abnormal_enzyme/_coenzyme0.52649079
149MP0003984_embryonic_growth_retardation0.52352800
150MP0005451_abnormal_body_composition0.51351559
151MP0005197_abnormal_uvea_morphology0.51298688
152MP0008877_abnormal_DNA_methylation0.50958055
153MP0002697_abnormal_eye_size0.50405606
154MP0005394_taste/olfaction_phenotype0.49410871
155MP0005499_abnormal_olfactory_system0.49410871

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)7.16905752
2Conjugated hyperbilirubinemia (HP:0002908)5.40225238
3Arterial tortuosity (HP:0005116)4.41336771
4Increased purine levels (HP:0004368)4.26647638
5Hyperuricemia (HP:0002149)4.26647638
6Spondylolisthesis (HP:0003302)4.14272267
7Amelogenesis imperfecta (HP:0000705)3.99313223
8Polyuria (HP:0000103)3.95332515
9Malnutrition (HP:0004395)3.88579184
10Vascular tortuosity (HP:0004948)3.86995229
11Facial shape deformation (HP:0011334)3.83979564
12Potter facies (HP:0002009)3.83979564
13Proximal tubulopathy (HP:0000114)3.78593930
14Abnormality of the nasal septum (HP:0000419)3.64413547
15Aortic dissection (HP:0002647)3.63935737
16Bilateral microphthalmos (HP:0007633)3.62095443
17Metabolic alkalosis (HP:0200114)3.62043897
18Abnormal urine output (HP:0012590)3.61851162
19Megaloblastic anemia (HP:0001889)3.45218066
20Abnormality of renal excretion (HP:0011036)3.41744375
21Abnormality of purine metabolism (HP:0004352)3.36936790
22Hypoplasia of the fovea (HP:0007750)3.35508161
23Aplasia/Hypoplasia of the fovea (HP:0008060)3.35508161
24Elfin facies (HP:0004428)3.23772326
25Vacuolated lymphocytes (HP:0001922)3.23567273
26Aplasia/hypoplasia of the uterus (HP:0008684)3.19353663
27Glucose intolerance (HP:0000833)3.18504213
28Spontaneous abortion (HP:0005268)3.15971204
29Premature rupture of membranes (HP:0001788)3.14772638
30Esophageal varix (HP:0002040)3.14305768
31Glycosuria (HP:0003076)3.09006592
32Abnormality of urine glucose concentration (HP:0011016)3.09006592
33Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.07865746
34Fused cervical vertebrae (HP:0002949)3.06342355
35Tubulointerstitial fibrosis (HP:0005576)3.00804600
36Abnormal drinking behavior (HP:0030082)2.99487286
37Polydipsia (HP:0001959)2.99487286
38Abnormal pancreas size (HP:0012094)2.99329490
39Cerebellar dysplasia (HP:0007033)2.92957764
40Increased circulating renin level (HP:0000848)2.91355303
41Hypokalemic alkalosis (HP:0001949)2.90785439
42Muscle fiber splitting (HP:0003555)2.88406828
43Renal tubular dysfunction (HP:0000124)2.85960048
44Stomach cancer (HP:0012126)2.84380854
45Hypobetalipoproteinemia (HP:0003563)2.82666278
46Carpal bone hypoplasia (HP:0001498)2.82590117
47Bilateral sensorineural hearing impairment (HP:0008619)2.82412631
48Ileus (HP:0002595)2.81868069
49Abnormality of proline metabolism (HP:0010907)2.80548515
50Hydroxyprolinuria (HP:0003080)2.80548515
51Generalized aminoaciduria (HP:0002909)2.76660729
52Neonatal death (HP:0003811)2.75160268
53Abnormality of renin-angiotensin system (HP:0000847)2.74751229
54Abnormality of the common coagulation pathway (HP:0010990)2.74119619
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.73977614
56Abnormality of alanine metabolism (HP:0010916)2.73977614
57Hyperalaninemia (HP:0003348)2.73977614
58Neoplasm of the adrenal cortex (HP:0100641)2.72800707
59Hyperactive renin-angiotensin system (HP:0000841)2.71334963
60Confusion (HP:0001289)2.67957965
61Abnormality of dental color (HP:0011073)2.65492335
62Dehydration (HP:0001944)2.64122077
63Bicornuate uterus (HP:0000813)2.63818191
64Chorioretinal atrophy (HP:0000533)2.63502832
65Abnormality of glycolipid metabolism (HP:0010969)2.61650035
66Abnormality of liposaccharide metabolism (HP:0010968)2.61650035
67Abnormality of glycosphingolipid metabolism (HP:0004343)2.61650035
68Hypercalciuria (HP:0002150)2.61455103
69Increased serum pyruvate (HP:0003542)2.59333286
70Decreased circulating renin level (HP:0003351)2.58207648
71Late onset (HP:0003584)2.55703449
72Long clavicles (HP:0000890)2.55602834
73Increased cerebral lipofuscin (HP:0011813)2.55441131
74Abnormality of the fovea (HP:0000493)2.54548930
75Osteolytic defects of the phalanges of the hand (HP:0009771)2.53086615
76Osteolytic defects of the hand bones (HP:0009699)2.53086615
77Hypothermia (HP:0002045)2.51506703
78Hyperglycinuria (HP:0003108)2.51252495
79Delayed epiphyseal ossification (HP:0002663)2.50549688
80Alkalosis (HP:0001948)2.49753986
81Abnormality of chloride homeostasis (HP:0011422)2.49700718
82Retinal atrophy (HP:0001105)2.47482105
83Hypomagnesemia (HP:0002917)2.46527401
84Ankle contracture (HP:0006466)2.43199685
85Rough bone trabeculation (HP:0100670)2.42541675
86Abnormal trabecular bone morphology (HP:0100671)2.40815004
87Nephrocalcinosis (HP:0000121)2.40372105
88Abnormality of the renal cortex (HP:0011035)2.39300116
89Hyperglycinemia (HP:0002154)2.38319792
90Renal tubular acidosis (HP:0001947)2.38185223
91Nausea (HP:0002018)2.36371125
92Hypoplasia of the uterus (HP:0000013)2.35032628
93Focal segmental glomerulosclerosis (HP:0000097)2.33984892
94Abnormality of nucleobase metabolism (HP:0010932)2.33831691
95Hypophosphatemic rickets (HP:0004912)2.32291882
96Type II lissencephaly (HP:0007260)2.24510444
97Osteomalacia (HP:0002749)2.23975846
98Renal cortical cysts (HP:0000803)2.23971540
99Abnormality of the aortic arch (HP:0012303)2.23681555
100Aortic valve stenosis (HP:0001650)2.21426379
101Tubular atrophy (HP:0000092)2.21031837
102Sensorimotor neuropathy (HP:0007141)2.20104959
103Aplasia/Hypoplasia of the macula (HP:0008059)2.18110662
104Abnormality of magnesium homeostasis (HP:0004921)2.15823729
105Abnormality of serine family amino acid metabolism (HP:0010894)2.15799442
106Abnormality of glycine metabolism (HP:0010895)2.15799442
107Abnormality of glycolysis (HP:0004366)2.12539399
108Nephrolithiasis (HP:0000787)2.12235433
109Abolished electroretinogram (ERG) (HP:0000550)2.10640412
110Hypokalemia (HP:0002900)2.10509066
111Thyroid-stimulating hormone excess (HP:0002925)2.10339434
112Prolonged neonatal jaundice (HP:0006579)2.10078805
113Abnormality of transition element cation homeostasis (HP:0011030)2.09249972
114Lethargy (HP:0001254)2.09010902
115Tetany (HP:0001281)2.08588066
116Increased neuronal autofluorescent lipopigment (HP:0002074)2.08098625
117Unilateral renal agenesis (HP:0000122)2.07434997
118Broad alveolar ridges (HP:0000187)2.06946466
119Shawl scrotum (HP:0000049)2.06934205
120Thin bony cortex (HP:0002753)2.06576504
121Aplasia/Hypoplasia affecting the retina (HP:0008061)2.06394883
122Abnormality of macular pigmentation (HP:0008002)2.05886426
123Cone-rod dystrophy (HP:0000548)2.03640471
124Autoamputation (HP:0001218)2.02515500
125Myopathic facies (HP:0002058)1.99774451
126Gastrointestinal dysmotility (HP:0002579)1.99479906
127Methylmalonic aciduria (HP:0012120)1.98747763
128Renal salt wasting (HP:0000127)1.98376517
129Increased CSF lactate (HP:0002490)1.98354372
130Abnormality of macrophages (HP:0004311)1.98289169
131Breast hypoplasia (HP:0003187)1.97148536
132Hyperammonemia (HP:0001987)1.96984062
133Bicuspid aortic valve (HP:0001647)1.94945625
134Aortic aneurysm (HP:0004942)1.94834153
135Dicarboxylic aciduria (HP:0003215)1.94390586
136Abnormality of dicarboxylic acid metabolism (HP:0010995)1.94390586
137Cervical subluxation (HP:0003308)1.93693975
138Pancreatic cysts (HP:0001737)1.93678303
139Increased serum ferritin (HP:0003281)1.92929210
140Abnormality of serum amino acid levels (HP:0003112)1.92626672
141Abnormality of the distal phalanges of the toes (HP:0010182)1.92146834
142Glomerulosclerosis (HP:0000096)1.92142295
143Abnormal glucose tolerance (HP:0001952)1.90869743
144Vascular calcification (HP:0004934)1.90276736
145Vomiting (HP:0002013)1.89798754
146Mucopolysacchariduria (HP:0008155)1.89711923
147Hypolipoproteinemia (HP:0010981)1.89622967
148Short tibia (HP:0005736)1.83851010
149Vitreoretinal degeneration (HP:0000655)1.81107525
150Pendular nystagmus (HP:0012043)1.80430823
151Abnormality of glutamine family amino acid metabolism (HP:0010902)1.79786108
152Azoospermia (HP:0000027)1.78712620
153Increased serum lactate (HP:0002151)1.78327288
154Stenosis of the external auditory canal (HP:0000402)1.78041833
155Aplasia/Hypoplasia of the tibia (HP:0005772)1.77809810
156Mitochondrial inheritance (HP:0001427)1.67776666
157Paralysis (HP:0003470)1.67300669
158Stage 5 chronic kidney disease (HP:0003774)1.64157635
159Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63938458
160Renal hypoplasia (HP:0000089)1.63000149
161Acute necrotizing encephalopathy (HP:0006965)1.62975983
162Patent foramen ovale (HP:0001655)1.60838727
163Increased hepatocellular lipid droplets (HP:0006565)1.60344974
164Cerebral palsy (HP:0100021)1.59869266
165Hyperphosphaturia (HP:0003109)1.58747173
166Abnormality of the renal medulla (HP:0100957)1.57895498

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.18417075
2ZAK4.94746523
3BUB13.50902344
4WEE13.47282192
5PBK3.41889429
6TTK3.08200661
7WNK42.66010366
8PNCK2.63558045
9MST1R2.36505169
10FRK2.30303864
11NEK12.09577872
12MAP4K22.09122786
13BMPR1B1.99578129
14MST41.97313933
15NME11.84007787
16EIF2AK11.83027375
17MYLK1.81312169
18LRRK21.74075093
19NUAK11.69698597
20ADRBK21.67827163
21MAP2K71.67713263
22STK38L1.60126915
23PLK31.59071357
24AKT31.58511120
25SGK31.54155769
26TGFBR21.54043140
27OXSR11.51764512
28BRSK21.49912024
29PRKCI1.48526027
30PINK11.46604314
31RPS6KB21.46471001
32PDK21.43056025
33MAP3K31.41672678
34NEK91.40028654
35TLK11.38613929
36ERBB41.38492283
37MAP3K41.30235163
38TNIK1.27792239
39CASK1.25561133
40STK381.20781818
41PAK41.20011958
42PDK41.19867477
43PDK31.19867477
44GRK11.16527356
45STK391.16128351
46NEK21.15288682
47CDK81.13386740
48TTN1.12702340
49BCR1.12553195
50EPHB11.11659317
51FGFR11.11480615
52WNK31.07662804
53BCKDK1.07504757
54STK101.07254288
55PRKCE1.07041729
56STK31.06816374
57PIK3CA1.04682634
58ABL21.01333954
59EIF2AK30.98902872
60FER0.98724628
61ERN10.98128195
62ACVR1B0.98058182
63PLK20.94638369
64DAPK20.94533186
65MET0.93809283
66LMTK20.93166964
67NME20.93166372
68TAOK30.92923153
69SCYL20.90443494
70IRAK30.85565059
71FGFR40.84962626
72MAP3K80.84853701
73PAK10.84627240
74BMX0.83035291
75TSSK60.83010961
76ARAF0.80648257
77EPHA30.80045434
78STK160.76933700
79INSRR0.76712532
80TRIB30.73693328
81PRKCZ0.72317802
82LATS20.72087847
83TXK0.71564704
84ALK0.70281963
85PTK20.69562911
86CSNK1A1L0.68678200
87AURKA0.67934244
88FGFR20.67756264
89CHEK20.66029669
90MAPK110.64969478
91FLT30.63653029
92PHKG10.63518969
93PHKG20.63518969
94AURKB0.62860511
95PLK10.61638525
96MAP3K120.61298068
97KDR0.59718629
98BRSK10.59513836
99FGFR30.56244586
100PKN10.55557036
101PLK40.54356976
102LATS10.53955832
103PRKCQ0.53692015
104TESK10.51774702
105DAPK30.51075180
106SGK4940.49985081
107SGK2230.49985081
108MAP2K20.48264224
109RPS6KA40.48257406
110GSK3A0.48207021
111PRKG20.48049751
112BRAF0.46065127
113SRPK10.45443578
114TRIM280.44636532
115ERBB20.44229962
116CAMKK20.43842033
117PDPK10.43622718
118PRKCD0.43096653
119ADRBK10.42952344
120CSNK1G10.42543958
121TAOK10.41266411
122NTRK30.40339523
123PTK60.40169128
124DAPK10.39344747
125CSNK1E0.39125324
126PRKAA10.38669635
127CDK90.38547981
128EPHB20.38501649
129MATK0.37821282
130IGF1R0.36888946
131PRKCA0.36844750
132AKT20.36695525
133CSNK1A10.36364904
134MAP3K70.36340998
135INSR0.36124119
136CDK30.35989296
137CAMK2G0.35162932
138CSNK2A10.34882120
139PRKAA20.34484743
140STK110.33174440
141STK40.32781991
142GRK60.32663301
143MAP3K90.32618125
144PAK30.31514320
145PIK3CG0.30859638
146MTOR0.30653002
147MAP2K60.30249743
148CSNK1G30.29957338
149CAMK2A0.29456253
150MAPKAPK20.28992785
151DMPK0.28605467
152PRKCG0.27239621
153PRKACB0.27082783
154TYK20.26983127
155MELK0.26177147
156PRKACA0.25781041
157ILK0.24802276
158TESK20.24738012

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin digestion and absorption_Homo sapiens_hsa049773.50882355
2Proteasome_Homo sapiens_hsa030503.19320556
3Steroid biosynthesis_Homo sapiens_hsa001002.94443407
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.81795584
5Pentose phosphate pathway_Homo sapiens_hsa000302.75717287
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.71585538
7Vitamin B6 metabolism_Homo sapiens_hsa007502.58736102
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.47461550
9Glutathione metabolism_Homo sapiens_hsa004802.44046997
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.35880393
11Mineral absorption_Homo sapiens_hsa049782.34912593
12Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.27940596
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.23382532
14Lysosome_Homo sapiens_hsa041422.19352455
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.15851913
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.15256456
17Regulation of autophagy_Homo sapiens_hsa041402.13039821
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.07119722
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.05519011
20Galactose metabolism_Homo sapiens_hsa000522.05230373
21Collecting duct acid secretion_Homo sapiens_hsa049662.03948047
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.97290730
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.85821105
24Nitrogen metabolism_Homo sapiens_hsa009101.84392833
25Other glycan degradation_Homo sapiens_hsa005111.82982701
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.80223812
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.68061540
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.66478892
29Carbon metabolism_Homo sapiens_hsa012001.60628012
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59154835
31Oxidative phosphorylation_Homo sapiens_hsa001901.52389679
32Sulfur metabolism_Homo sapiens_hsa009201.50154177
33Sphingolipid metabolism_Homo sapiens_hsa006001.49668246
34Starch and sucrose metabolism_Homo sapiens_hsa005001.47061306
35Chemical carcinogenesis_Homo sapiens_hsa052041.38660343
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.38460227
37Fat digestion and absorption_Homo sapiens_hsa049751.37915639
38Phototransduction_Homo sapiens_hsa047441.37477100
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.36391901
40Folate biosynthesis_Homo sapiens_hsa007901.36261088
41Renin-angiotensin system_Homo sapiens_hsa046141.34942622
42Basal transcription factors_Homo sapiens_hsa030221.31832486
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31802763
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28655309
45RNA polymerase_Homo sapiens_hsa030201.23999027
46Protein export_Homo sapiens_hsa030601.20533253
47Bile secretion_Homo sapiens_hsa049761.16354221
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16001167
49Arginine and proline metabolism_Homo sapiens_hsa003301.14011447
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.12612276
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11339749
52Primary bile acid biosynthesis_Homo sapiens_hsa001201.09679442
53Arginine biosynthesis_Homo sapiens_hsa002201.07488683
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05859919
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05326832
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02251239
57Pyruvate metabolism_Homo sapiens_hsa006201.01197567
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.00041984
59Peroxisome_Homo sapiens_hsa041460.99183602
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99123666
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98696591
62Propanoate metabolism_Homo sapiens_hsa006400.98262201
63Rheumatoid arthritis_Homo sapiens_hsa053230.98043129
64Tight junction_Homo sapiens_hsa045300.98042783
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96824444
66Fructose and mannose metabolism_Homo sapiens_hsa000510.96503535
67Caffeine metabolism_Homo sapiens_hsa002320.95432558
68Ether lipid metabolism_Homo sapiens_hsa005650.94716195
69Pyrimidine metabolism_Homo sapiens_hsa002400.94476961
70RNA transport_Homo sapiens_hsa030130.94106252
71beta-Alanine metabolism_Homo sapiens_hsa004100.93702975
72One carbon pool by folate_Homo sapiens_hsa006700.93390962
73Cell cycle_Homo sapiens_hsa041100.91888193
74Fatty acid degradation_Homo sapiens_hsa000710.89299389
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87976133
76ABC transporters_Homo sapiens_hsa020100.86634171
77PPAR signaling pathway_Homo sapiens_hsa033200.84668287
78Biosynthesis of amino acids_Homo sapiens_hsa012300.84236464
79ECM-receptor interaction_Homo sapiens_hsa045120.84230048
80Ribosome_Homo sapiens_hsa030100.81856842
81Homologous recombination_Homo sapiens_hsa034400.81500551
82p53 signaling pathway_Homo sapiens_hsa041150.81422400
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80673319
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80361920
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79511490
86N-Glycan biosynthesis_Homo sapiens_hsa005100.79158009
87Parkinsons disease_Homo sapiens_hsa050120.75902671
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.74914713
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73500350
90Vibrio cholerae infection_Homo sapiens_hsa051100.73033337
91Butanoate metabolism_Homo sapiens_hsa006500.72127565
92RNA degradation_Homo sapiens_hsa030180.70718209
93Endocytosis_Homo sapiens_hsa041440.67122156
94Arachidonic acid metabolism_Homo sapiens_hsa005900.66622639
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.65246460
96Huntingtons disease_Homo sapiens_hsa050160.64180407
97Hippo signaling pathway_Homo sapiens_hsa043900.64167969
98Glycerolipid metabolism_Homo sapiens_hsa005610.60376804
99Histidine metabolism_Homo sapiens_hsa003400.60335272
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59352835
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.57961546
102Retinol metabolism_Homo sapiens_hsa008300.57714050
103Linoleic acid metabolism_Homo sapiens_hsa005910.56389408
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54552703
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52494340
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51102933
107MicroRNAs in cancer_Homo sapiens_hsa052060.50955125
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49711179
109Metabolic pathways_Homo sapiens_hsa011000.49570483
110Fatty acid elongation_Homo sapiens_hsa000620.49471554
111Gastric acid secretion_Homo sapiens_hsa049710.49390083
112Synaptic vesicle cycle_Homo sapiens_hsa047210.49205085
113Complement and coagulation cascades_Homo sapiens_hsa046100.47772431
114Proteoglycans in cancer_Homo sapiens_hsa052050.47437260
115Thyroid hormone synthesis_Homo sapiens_hsa049180.45188028
116Focal adhesion_Homo sapiens_hsa045100.43988516
117Adherens junction_Homo sapiens_hsa045200.43591357
118African trypanosomiasis_Homo sapiens_hsa051430.42373744
119Selenocompound metabolism_Homo sapiens_hsa004500.41271454
120Purine metabolism_Homo sapiens_hsa002300.41012770
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40758906
122Antigen processing and presentation_Homo sapiens_hsa046120.40600941
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.39961947
124Base excision repair_Homo sapiens_hsa034100.39771419
125NF-kappa B signaling pathway_Homo sapiens_hsa040640.38575780
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37638525
127Renal cell carcinoma_Homo sapiens_hsa052110.37626239
128Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37472843
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37019115
130Tuberculosis_Homo sapiens_hsa051520.34676927
131DNA replication_Homo sapiens_hsa030300.33884262
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33785511
133Oocyte meiosis_Homo sapiens_hsa041140.33676485
134Phagosome_Homo sapiens_hsa041450.33599681
135Alzheimers disease_Homo sapiens_hsa050100.31900754
136Tryptophan metabolism_Homo sapiens_hsa003800.31871226
137Fatty acid metabolism_Homo sapiens_hsa012120.31296968
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31021497
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30864899
140Shigellosis_Homo sapiens_hsa051310.30644370

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